Statistics for Biologists (November 2007)

**Session 1: Descriptive statistics and introduction to inferential statistics** 7th floor classroom

- Slides [slide show] [to print]
- Exercises for lecture 1
- Excel help: Background info about Excel conventions
- Connecting to R on tak (optional)
- Answers to some class questions

**Session 2: Inferential statistics: pairwise comparisons, power, and multiple testing** 7th floor classroom

- Slides [slide show] [to print]
- Exercises for lecture 2 - part 1: Explore the R Commander
- Exercises for lecture 2 - part 2: Perform pairwise comparisons, power calculations, and multiple hypothesis testing.

**Session 3: Selected biostatistical applications** 7th floor classroom

**WIBR BaRC help pages**

**Statistics textbooks on the web**

- StatSoft Electronic Statistics Textbook (StatSoft)

- The Little Handbook of Statistical Practice (Gerard E. Dallal; Tufts)
- Statistics at Square One (eBMJ)
- Introduction to Probability (Grinstead and Snell; Dartmouth)
- A New View of Statistics (sportsci.org)
- Investigating Statistics (Penn State)

**More information and references**

- Statistics for Biology: series of 3 lectures presented by Vince Carey in 2003
- Introductory Statistics: Concepts, Models, and Applications
- SISA: Simple Interactive Statistical Analysis
- Statnotes: An Online Textbook
- CancerGuide: Statistics
- Collection of Biostatistics Research Archive (lots of good tutorial-style papers)
- Multiple Testing Corrections (Silicon Genetics)
- BioConductor (microarray analysis software written in R) - See "Documentation > Short Courses" for lots of presentations.
- Receiver Operating Characteristic curves: good description and interactive examples of ROC curves

**R and S resources**

- The R Project for Statistical Computing: software and lots of documentation
- Bioconductor: R packages for the analysis of microarray and other genomic data
- Rpad Reference Card for R: a helpful list of commands
- Other R reference cards: Baron Short
- Getting Started with the R Commander: a graphical interface for learning R
- The R Commander: details about individual tools
- Introduction to statistical computing in R: course materials by the creater of the R Commander

**Links to publications**

- Storey JD and Tibshirani R.Statistical significance for genomewide studies. PNAS: 100(16):9440-5, 2003.

Bioinformatics and Research Computing at Whitehead Institute