>NP_000089.1| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Homo sapiens] >gi|416836|sp|P23786.2|CPT2_HUMAN RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|180989|gb|AAB59462.1| carnitine palmitoyltransferase [Homo sapiens] >gi|1041193|gb|AAB60382.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|1041195|gb|AAB60383.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|56205394|emb|CAI18907.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|119627158|gb|EAX06753.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|189053401|dbj|BAG35567.1| unnamed protein product [Homo sapiens] >NP_034079.2| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Mus musculus] >gi|341940396|sp|P52825.2|CPT2_MOUSE RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|74139371|dbj|BAE40828.1| unnamed protein product [Mus musculus] >gi|123244562|emb|CAM23589.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148698814|gb|EDL30761.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148877636|gb|AAI45860.1| Carnitine palmitoyltransferase 2 [Mus musculus] >gi|187953945|gb|AAI38515.1| Carnitine palmitoyltransferase 2 [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000089.1| MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDT NP_034079.2| MMPRLLLRDWPRCPSLVLGAPSRPLSAVSGPAEYLQHSIVPTMHYQDSLPRLPIPKLEDT * ****** *** * ********* *** *** *********************** NP_000089.1| IRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMY NP_034079.2| MKRYLSAQKPLLNDSQFRKTEVLCKDFENGIGKELHAHLLAQDKQNKHTSYISGPWFDMY ************ ****** ** ********** * * ****************** NP_000089.1| LSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNP NP_034079.2| LTARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFLKTLRAGLLEPEVFHLNP * ******************************** **** ******************** NP_000089.1| AKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKA NP_034079.2| ARSDTDAFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRIPKPSRDELFTDTKA * *** ************************************** *********** ** NP_000089.1| RHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA NP_034079.2| RHLLVLRKGHFYVFDVLDQDGNIVNPSEIQAHLKYILSDSSPVPEFPLAYLTSENRDVWA ********* ** *********** ***************** ************** ** NP_000089.1| ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLII NP_034079.2| ELRQKLIHGGNEETLRKVDSAVFCLCLDDFPMKDLVHLSHTMLHGDGTNRWFDKSFNLIV ****** **** ***************** ******** ****************** NP_000089.1| AKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELT NP_034079.2| AKDGTAAVHFEHAWGDGVAVLRFFNEVFRDSTQTPAIAPQSQPAATDSSVSVQKLSFKLS **** ****** *************** ******* ****** *** * **** * * NP_000089.1| DALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYG NP_034079.2| SALKAGVTAAKEKFDATMKTLTIDAIQFQRGGKEFLKKKKLSPDAVAQLAFQMAFLRQYG *** * ***************** ************ ********************* NP_000089.1| QTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHG NP_034079.2| QTVATYESCSTAAFKHGRTETIRPASIFTKRCSEAFVREPSKHSVGELQHMMAECSKYHG ************************** ************* ** **** ** ******* NP_000089.1| QLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG NP_034079.2| QLTKEAAMGQGFDRHLFALRYLAAARGVTLPELYQDPAYQRINHNILSTSTLSSPAVSLG ******************** **** * ***** **** **** *********** ** NP_000089.1| GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS NP_034079.2| GFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDMFDALEGKAIKT ****** **** ***** ********* ******** ** * *********** ** >NP_000089.1| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Homo sapiens] >gi|416836|sp|P23786.2|CPT2_HUMAN RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|180989|gb|AAB59462.1| carnitine palmitoyltransferase [Homo sapiens] >gi|1041193|gb|AAB60382.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|1041195|gb|AAB60383.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|56205394|emb|CAI18907.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|119627158|gb|EAX06753.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|189053401|dbj|BAG35567.1| unnamed protein product [Homo sapiens] >NP_034079.2| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Mus musculus] >gi|341940396|sp|P52825.2|CPT2_MOUSE RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|74139371|dbj|BAE40828.1| unnamed protein product [Mus musculus] >gi|123244562|emb|CAM23589.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148698814|gb|EDL30761.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148877636|gb|AAI45860.1| Carnitine palmitoyltransferase 2 [Mus musculus] >gi|187953945|gb|AAI38515.1| Carnitine palmitoyltransferase 2 [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:28:59 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000089 # 2: NP_034079 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 658 # Identity: 574/658 (87.2%) # Similarity: 620/658 (94.2%) # Gaps: 0/658 ( 0.0%) # Score: 3085.0 # # #======================================= NP_000089 1 MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLP 50 |:||||||.|||.|::..|||||||||.|||.:|||.||||||||||||| NP_034079 1 MMPRLLLRDWPRCPSLVLGAPSRPLSAVSGPAEYLQHSIVPTMHYQDSLP 50 NP_000089 51 RLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLV 100 ||||||||||::||||||||||||.||||||..||.||||||||||..|: NP_034079 51 RLPIPKLEDTMKRYLSAQKPLLNDSQFRKTEVLCKDFENGIGKELHAHLL 100 NP_000089 101 ALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLT 150 |.|||||||||||||||||||:|||||||||||||||||||||||||||| NP_034079 101 AQDKQNKHTSYISGPWFDMYLTARDSVVLNFNPFMAFNPDPKSEYNDQLT 150 NP_000089 151 RATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLS 200 ||||:||||:|||||||||||||||||||||:|||..||||||||||||| NP_034079 151 RATNLTVSAVRFLKTLRAGLLEPEVFHLNPARSDTDAFKRLIRFVPSSLS 200 NP_000089 201 WYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGN 250 |||||||||||||||||||||||||:|||||||||||.|||||||||||: NP_034079 201 WYGAYLVNAYPLDMSQYFRLFNSTRIPKPSRDELFTDTKARHLLVLRKGH 250 NP_000089 251 FYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA 300 ||:|||||||||||:|||||||||||||||||.||||||||||||||:|| NP_034079 251 FYVFDVLDQDGNIVNPSEIQAHLKYILSDSSPVPEFPLAYLTSENRDVWA 300 NP_000089 301 ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNR 350 ||||||:..||||:|||||||||||||||||:||||||||.||||||||| NP_034079 301 ELRQKLIHGGNEETLRKVDSAVFCLCLDDFPMKDLVHLSHTMLHGDGTNR 350 NP_000089 351 WFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQ 400 |||||||||:||||:.||||||:|||||||||||||||:|||||||:.|| NP_034079 351 WFDKSFNLIVAKDGTAAVHFEHAWGDGVAVLRFFNEVFRDSTQTPAIAPQ 400 NP_000089 401 SQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQR 450 ||||.|||:|:||||:|:|:.|||.|:|||||||||||||||||.:|||| NP_034079 401 SQPAATDSSVSVQKLSFKLSSALKAGVTAAKEKFDATMKTLTIDAIQFQR 450 NP_000089 451 GGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTE 500 ||||||||:||||||||||||||||||||||||||||||||||||||||| NP_034079 451 GGKEFLKKKKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTE 500 NP_000089 501 TIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQ 550 ||||||::|||||||||||||:||.||||.||.||||||||||||||||| NP_034079 501 TIRPASIFTKRCSEAFVREPSKHSVGELQHMMAECSKYHGQLTKEAAMGQ 550 NP_000089 551 GFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG 600 ||||||||||:||||:|:.|||||.||||.:||||:|||||||||||:|| NP_034079 551 GFDRHLFALRYLAAARGVTLPELYQDPAYQRINHNILSTSTLSSPAVSLG 600 NP_000089 601 GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDA 650 ||||||.||||:.|||||:|||||||||.||||||||.||:|.||||||| NP_034079 601 GFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDMFDA 650 NP_000089 651 LEGKSIKS 658 ||||:||: NP_034079 651 LEGKAIKT 658 #--------------------------------------- #--------------------------------------- >NP_000089.1| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Homo sapiens] >gi|416836|sp|P23786.2|CPT2_HUMAN RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|180989|gb|AAB59462.1| carnitine palmitoyltransferase [Homo sapiens] >gi|1041193|gb|AAB60382.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|1041195|gb|AAB60383.1| carnitine palmitoyltransferase II precursor [Homo sapiens] >gi|56205394|emb|CAI18907.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|119627158|gb|EAX06753.1| carnitine palmitoyltransferase II [Homo sapiens] >gi|189053401|dbj|BAG35567.1| unnamed protein product [Homo sapiens] >NP_034079.2| carnitine O-palmitoyltransferase 2, mitochondrial precursor [Mus musculus] >gi|341940396|sp|P52825.2|CPT2_MOUSE RecName: Full=Carnitine O-palmitoyltransferase 2, mitochondrial; AltName: Full=Carnitine palmitoyltransferase II; Short=CPT II; Flags: Precursor >gi|74139371|dbj|BAE40828.1| unnamed protein product [Mus musculus] >gi|123244562|emb|CAM23589.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148698814|gb|EDL30761.1| carnitine palmitoyltransferase 2 [Mus musculus] >gi|148877636|gb|AAI45860.1| Carnitine palmitoyltransferase 2 [Mus musculus] >gi|187953945|gb|AAI38515.1| Carnitine palmitoyltransferase 2 [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:28:59 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000089 # 2: NP_034079 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 658 # Identity: 574/658 (87.2%) # Similarity: 620/658 (94.2%) # Gaps: 0/658 ( 0.0%) # Score: 3085.0 # # #======================================= NP_000089 1 MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLP 50 |:||||||.|||.|::..|||||||||.|||.:|||.||||||||||||| NP_034079 1 MMPRLLLRDWPRCPSLVLGAPSRPLSAVSGPAEYLQHSIVPTMHYQDSLP 50 NP_000089 51 RLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLV 100 ||||||||||::||||||||||||.||||||..||.||||||||||..|: NP_034079 51 RLPIPKLEDTMKRYLSAQKPLLNDSQFRKTEVLCKDFENGIGKELHAHLL 100 NP_000089 101 ALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLT 150 |.|||||||||||||||||||:|||||||||||||||||||||||||||| NP_034079 101 AQDKQNKHTSYISGPWFDMYLTARDSVVLNFNPFMAFNPDPKSEYNDQLT 150 NP_000089 151 RATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLS 200 ||||:||||:|||||||||||||||||||||:|||..||||||||||||| NP_034079 151 RATNLTVSAVRFLKTLRAGLLEPEVFHLNPARSDTDAFKRLIRFVPSSLS 200 NP_000089 201 WYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGN 250 |||||||||||||||||||||||||:|||||||||||.|||||||||||: NP_034079 201 WYGAYLVNAYPLDMSQYFRLFNSTRIPKPSRDELFTDTKARHLLVLRKGH 250 NP_000089 251 FYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA 300 ||:|||||||||||:|||||||||||||||||.||||||||||||||:|| NP_034079 251 FYVFDVLDQDGNIVNPSEIQAHLKYILSDSSPVPEFPLAYLTSENRDVWA 300 NP_000089 301 ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNR 350 ||||||:..||||:|||||||||||||||||:||||||||.||||||||| NP_034079 301 ELRQKLIHGGNEETLRKVDSAVFCLCLDDFPMKDLVHLSHTMLHGDGTNR 350 NP_000089 351 WFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQ 400 |||||||||:||||:.||||||:|||||||||||||||:|||||||:.|| NP_034079 351 WFDKSFNLIVAKDGTAAVHFEHAWGDGVAVLRFFNEVFRDSTQTPAIAPQ 400 NP_000089 401 SQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQR 450 ||||.|||:|:||||:|:|:.|||.|:|||||||||||||||||.:|||| NP_034079 401 SQPAATDSSVSVQKLSFKLSSALKAGVTAAKEKFDATMKTLTIDAIQFQR 450 NP_000089 451 GGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTE 500 ||||||||:||||||||||||||||||||||||||||||||||||||||| NP_034079 451 GGKEFLKKKKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTE 500 NP_000089 501 TIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQ 550 ||||||::|||||||||||||:||.||||.||.||||||||||||||||| NP_034079 501 TIRPASIFTKRCSEAFVREPSKHSVGELQHMMAECSKYHGQLTKEAAMGQ 550 NP_000089 551 GFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG 600 ||||||||||:||||:|:.|||||.||||.:||||:|||||||||||:|| NP_034079 551 GFDRHLFALRYLAAARGVTLPELYQDPAYQRINHNILSTSTLSSPAVSLG 600 NP_000089 601 GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDA 650 ||||||.||||:.|||||:|||||||||.||||||||.||:|.||||||| NP_034079 601 GFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDMFDA 650 NP_000089 651 LEGKSIKS 658 ||||:||: NP_034079 651 LEGKAIKT 658 #--------------------------------------- #--------------------------------------- >NP_000244.2| microsomal triglyceride transfer protein large subunit precursor [Homo sapiens] >gi|1709167|sp|P55157.1|MTP_HUMAN RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|414669|emb|CAA53217.1| microsomal triglyceride transfer protein, 97kDa subunit [Homo sapiens] >gi|1834501|emb|CAA58142.1| MTP [Homo sapiens] >gi|115528724|gb|AAI25112.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|115528911|gb|AAI25111.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|158255022|dbj|BAF83482.1| unnamed protein product [Homo sapiens] >gi|450069|prf||1920361A triglyceride transfer protein:SUBUNIT=L >NP_032668.2| microsomal triglyceride transfer protein large subunit isoform 2 precursor [Mus musculus] >gi|284018098|sp|O08601.2|MTP_MOUSE RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|74138910|dbj|BAE27255.1| unnamed protein product [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000244.2| MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS NP_032668.2| MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKIS *********** ****************** *********** ** **** ****** ** NP_000244.2| SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ NP_032668.2| SDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQ * *** ************ ** * ***** ********* *** ** ** ****** NP_000244.2| RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA NP_032668.2| RPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQA ** **** ********* ** * *** ********* ************** ******* NP_000244.2| HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL NP_032668.2| QQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFAL **** ****** *** ****** *********************** ******* * * NP_000244.2| NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG NP_032668.2| NFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKG ** *** ******************* *** * ******** ******** *** NP_000244.2| CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV NP_032668.2| CPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLV **** * * * ** * * ******** ********** ******** * ******** NP_000244.2| DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG NP_032668.2| DAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFA ******** ******************************* ** ******* ****** NP_000244.2| SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA NP_032668.2| SNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNA * **** **** * ***************************** ****** ********* NP_000244.2| LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR NP_032668.2| LLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVR ******* *********** ****** ***** ************************** NP_000244.2| TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM NP_032668.2| TTAAAVILKNP-SYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEM * *** ** * **************** ******* ***** ******* ******* NP_000244.2| VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH NP_032668.2| AVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELH ******* ********** ***** ****************************** ** NP_000244.2| GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA NP_032668.2| GSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA ************ *********************************************** NP_000244.2| SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN NP_032668.2| SGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKN **** ************** ********* * ********** **************** NP_000244.2| RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF NP_032668.2| RVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQF ** **** * *** ****** * *************************** *** *** NP_000244.2| EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQP-DSTSSGWF NP_032668.2| ETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF * ************* **** **** ********** *** *** * *** >NP_000244.2| microsomal triglyceride transfer protein large subunit precursor [Homo sapiens] >gi|1709167|sp|P55157.1|MTP_HUMAN RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|414669|emb|CAA53217.1| microsomal triglyceride transfer protein, 97kDa subunit [Homo sapiens] >gi|1834501|emb|CAA58142.1| MTP [Homo sapiens] >gi|115528724|gb|AAI25112.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|115528911|gb|AAI25111.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|158255022|dbj|BAF83482.1| unnamed protein product [Homo sapiens] >gi|450069|prf||1920361A triglyceride transfer protein:SUBUNIT=L >NP_032668.2| microsomal triglyceride transfer protein large subunit isoform 2 precursor [Mus musculus] >gi|284018098|sp|O08601.2|MTP_MOUSE RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|74138910|dbj|BAE27255.1| unnamed protein product [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:00 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000244 # 2: NP_032668 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 895 # Identity: 768/895 (85.8%) # Similarity: 827/895 (92.4%) # Gaps: 2/895 ( 0.2%) # Score: 3916.0 # # #======================================= NP_000244 1 MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGK 50 |||||||||||.||||||||||||||||||:|||||||||||.||.|||| NP_032668 1 MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGK 50 NP_000244 51 LQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKS 100 .||||||:|||:|||.||||||||||||:||:|:..|||||..||||||| NP_032668 51 PQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKS 100 NP_000244 101 IFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKR 150 ||:|||..||:||:||||||||.||||:.|||||||||:||.|.|||:|| NP_032668 101 IFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKR 150 NP_000244 151 GLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSG 200 |||||||.||||||||||||||:|||||||.||||:||||||:|||.||| NP_032668 151 GLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSG 200 NP_000244 201 FTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKI 250 |||.|||||||||||||||||||||||.|||||||..|.|||.|||.||| NP_032668 201 FTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKI 250 NP_000244 251 VSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG 300 ||||||||||||||||::.|||.|.:||||||||.||||||||.:..||| NP_032668 251 VSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKG 300 NP_000244 301 CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKM 350 ||||:|.|:|.||.|:|:||||||||::||||||||||:::||||||||. NP_032668 301 CPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKA 350 NP_000244 351 ENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFA 400 |.||||||||||||||||.||||||||||||||||||||||||||||||| NP_032668 351 EKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFA 400 NP_000244 401 SHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAV 450 :||:|||||||:||||||..|:||||:||||.|.|||||||||||||||| NP_032668 401 THPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAV 450 NP_000244 451 VEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPI 500 |||||||||||||.||||||.||||||||||||||||.|||||||||||: NP_032668 451 VEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPV 500 NP_000244 501 SHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNN 550 ||||||.|||||:.|||||||||||||||||||||||||||.|||:|| . NP_032668 501 SHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVIL-K 549 NP_000244 551 NPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM 600 ||||||||||||||||||:|||||||.:|||||.|||||||::||||||| NP_032668 550 NPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEM 599 NP_000244 601 VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNI 650 ..|||||||:||||||||||:|||||:||||||||||||||||||||||| NP_032668 600 AVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNI 649 NP_000244 651 FQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQ 700 |||||||.||||||||||||||.||||||||||||||||||||||||||| NP_032668 650 FQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQ 699 NP_000244 701 LRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKAN 750 ||||||||||||||||||||||||:||||||||||||||::||||||||| NP_032668 700 LRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKAN 749 NP_000244 751 IEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAG 800 :|:||||||||||:||||||||||||||||||.||||:|:|||:|||||| NP_032668 750 MEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAG 799 NP_000244 801 LETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTG 850 :|:..|||||||||||||||||||||||||||.|||.||||.|||||||| NP_032668 800 VESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTG 849 NP_000244 851 RGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDS-TSSGWF 894 |||||::||||::||||.||||||||||.|||.|||:| .|.||| NP_032668 850 RGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF 894 #--------------------------------------- #--------------------------------------- >NP_000244.2| microsomal triglyceride transfer protein large subunit precursor [Homo sapiens] >gi|1709167|sp|P55157.1|MTP_HUMAN RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|414669|emb|CAA53217.1| microsomal triglyceride transfer protein, 97kDa subunit [Homo sapiens] >gi|1834501|emb|CAA58142.1| MTP [Homo sapiens] >gi|115528724|gb|AAI25112.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|115528911|gb|AAI25111.1| Microsomal triglyceride transfer protein [Homo sapiens] >gi|158255022|dbj|BAF83482.1| unnamed protein product [Homo sapiens] >gi|450069|prf||1920361A triglyceride transfer protein:SUBUNIT=L >NP_032668.2| microsomal triglyceride transfer protein large subunit isoform 2 precursor [Mus musculus] >gi|284018098|sp|O08601.2|MTP_MOUSE RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor >gi|74138910|dbj|BAE27255.1| unnamed protein product [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:00 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000244 # 2: NP_032668 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 895 # Identity: 768/895 (85.8%) # Similarity: 827/895 (92.4%) # Gaps: 2/895 ( 0.2%) # Score: 3916.0 # # #======================================= NP_000244 1 MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGK 50 |||||||||||.||||||||||||||||||:|||||||||||.||.|||| NP_032668 1 MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGK 50 NP_000244 51 LQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKS 100 .||||||:|||:|||.||||||||||||:||:|:..|||||..||||||| NP_032668 51 PQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKS 100 NP_000244 101 IFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKR 150 ||:|||..||:||:||||||||.||||:.|||||||||:||.|.|||:|| NP_032668 101 IFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKR 150 NP_000244 151 GLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSG 200 |||||||.||||||||||||||:|||||||.||||:||||||:|||.||| NP_032668 151 GLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSG 200 NP_000244 201 FTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKI 250 |||.|||||||||||||||||||||||.|||||||..|.|||.|||.||| NP_032668 201 FTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKI 250 NP_000244 251 VSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG 300 ||||||||||||||||::.|||.|.:||||||||.||||||||.:..||| NP_032668 251 VSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKG 300 NP_000244 301 CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKM 350 ||||:|.|:|.||.|:|:||||||||::||||||||||:::||||||||. NP_032668 301 CPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKA 350 NP_000244 351 ENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFA 400 |.||||||||||||||||.||||||||||||||||||||||||||||||| NP_032668 351 EKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFA 400 NP_000244 401 SHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAV 450 :||:|||||||:||||||..|:||||:||||.|.|||||||||||||||| NP_032668 401 THPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAV 450 NP_000244 451 VEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPI 500 |||||||||||||.||||||.||||||||||||||||.|||||||||||: NP_032668 451 VEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPV 500 NP_000244 501 SHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNN 550 ||||||.|||||:.|||||||||||||||||||||||||||.|||:|| . NP_032668 501 SHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVIL-K 549 NP_000244 551 NPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM 600 ||||||||||||||||||:|||||||.:|||||.|||||||::||||||| NP_032668 550 NPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEM 599 NP_000244 601 VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNI 650 ..|||||||:||||||||||:|||||:||||||||||||||||||||||| NP_032668 600 AVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNI 649 NP_000244 651 FQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQ 700 |||||||.||||||||||||||.||||||||||||||||||||||||||| NP_032668 650 FQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQ 699 NP_000244 701 LRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKAN 750 ||||||||||||||||||||||||:||||||||||||||::||||||||| NP_032668 700 LRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKAN 749 NP_000244 751 IEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAG 800 :|:||||||||||:||||||||||||||||||.||||:|:|||:|||||| NP_032668 750 MEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAG 799 NP_000244 801 LETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTG 850 :|:..|||||||||||||||||||||||||||.|||.||||.|||||||| NP_032668 800 VESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTG 849 NP_000244 851 RGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDS-TSSGWF 894 |||||::||||::||||.||||||||||.|||.|||:| .|.||| NP_032668 850 RGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF 894 #--------------------------------------- #--------------------------------------- >NP_000279.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|3122596|sp|O00628.1|PEX7_HUMAN RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|7157950|gb|AAF37350.1|AF180814_1 peroxisomal PTS2 receptor [Homo sapiens] >gi|1907315|gb|AAB50556.1| peroxisome targeting signal 2 receptor [Homo sapiens] >gi|1947088|gb|AAC51238.1| HsPex7p [Homo sapiens] >gi|13623328|gb|AAH06268.1| Peroxisomal biogenesis factor 7 [Homo sapiens] >gi|49457061|emb|CAG46851.1| PEX7 [Homo sapiens] >gi|49457105|emb|CAG46873.1| PEX7 [Homo sapiens] >gi|55957179|emb|CAI15471.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|55959581|emb|CAI15714.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|60823463|gb|AAX36645.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|119568325|gb|EAW47940.1| peroxisomal biogenesis factor 7, isoform CRA_a [Homo sapiens] >gi|261861320|dbj|BAI47182.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|312151094|gb|ADQ32059.1| peroxisomal biogenesis factor 7 [synthetic construct] >NP_032848.1| peroxisomal biogenesis factor 7 isoform 1 [Mus musculus] >gi|3122602|sp|P97865.1|PEX7_MOUSE RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|1890657|gb|AAB49755.1| peroxisomal PTS2 receptor [Mus musculus] >gi|124297903|gb|AAI32214.1| Peroxisomal biogenesis factor 7 [Mus musculus] >gi|124376084|gb|AAI32504.1| Peroxisomal biogenesis factor 7 [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000279.1| MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL NP_032848.1| -----MSAARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLVLDQNESGLQI *** ** ********************* ************* ** * ** NP_000279.1| FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS NP_032848.1| FRSFDWNDGLFDVTWSENNEHVLVTCSGDGSLQLWDTAKATGPLQVYKEHTQEVYSVDWS *********************** **************** ********* ********* NP_000279.1| QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL NP_032848.1| QTRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHIPGCFASASGDQTL ****************** ****** ********** *********************** NP_000279.1| RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG NP_032848.1| RIWDVKTTGVRIVIPAHQTEILSCDWCKYNENLVVTGAVDCSLRGWDLRNVRQPVFELLG ****** ********** ************** ************************** NP_000279.1| HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT NP_032848.1| HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDPLLETVEHHTEFTCGLDLSLQSPT ************************************ **************** ****** NP_000279.1| QVADCSWDETIKIYDPACLTIPA NP_032848.1| QVADCSWDETIKIYDPVCLTVPG **************** *** * >NP_000279.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|3122596|sp|O00628.1|PEX7_HUMAN RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|7157950|gb|AAF37350.1|AF180814_1 peroxisomal PTS2 receptor [Homo sapiens] >gi|1907315|gb|AAB50556.1| peroxisome targeting signal 2 receptor [Homo sapiens] >gi|1947088|gb|AAC51238.1| HsPex7p [Homo sapiens] >gi|13623328|gb|AAH06268.1| Peroxisomal biogenesis factor 7 [Homo sapiens] >gi|49457061|emb|CAG46851.1| PEX7 [Homo sapiens] >gi|49457105|emb|CAG46873.1| PEX7 [Homo sapiens] >gi|55957179|emb|CAI15471.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|55959581|emb|CAI15714.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|60823463|gb|AAX36645.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|119568325|gb|EAW47940.1| peroxisomal biogenesis factor 7, isoform CRA_a [Homo sapiens] >gi|261861320|dbj|BAI47182.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|312151094|gb|ADQ32059.1| peroxisomal biogenesis factor 7 [synthetic construct] >NP_032848.1| peroxisomal biogenesis factor 7 isoform 1 [Mus musculus] >gi|3122602|sp|P97865.1|PEX7_MOUSE RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|1890657|gb|AAB49755.1| peroxisomal PTS2 receptor [Mus musculus] >gi|124297903|gb|AAI32214.1| Peroxisomal biogenesis factor 7 [Mus musculus] >gi|124376084|gb|AAI32504.1| Peroxisomal biogenesis factor 7 [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:00 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000279 # 2: NP_032848 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 323 # Identity: 292/323 (90.4%) # Similarity: 302/323 (93.5%) # Gaps: 5/323 ( 1.5%) # Score: 1634.0 # # #======================================= NP_000279 1 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLI 50 ..|||.||.|||||||||||||||||||||.|||||||||||||: NP_032848 1 -----MSAARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLV 45 NP_000279 51 LDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKA 100 ||.:|:||::|||||||||||||||||||||||:|||||||||||||||| NP_032848 46 LDQNESGLQIFRSFDWNDGLFDVTWSENNEHVLVTCSGDGSLQLWDTAKA 95 NP_000279 101 AGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCT 150 .|||||||||.|||||||||||||||||||||||||||:||||||.|||| NP_032848 96 TGPLQVYKEHTQEVYSVDWSQTRGEQLVVSGSWDQTVKVWDPTVGNSLCT 145 NP_000279 151 FRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAE 200 ||||||:|||||||||||||||||||||||||||||..||||||||||.| NP_032848 146 FRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVKTTGVRIVIPAHQTE 195 NP_000279 201 ILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKF 250 |||||||||||||:|||||||||||||||||||||||||||||||||||| NP_032848 196 ILSCDWCKYNENLVVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKF 245 NP_000279 251 SPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT 300 ||||||||||||||||||||||||||.||||||||||||||||.|||||| NP_032848 246 SPFHASVLASCSYDFTVRFWNFSKPDPLLETVEHHTEFTCGLDLSLQSPT 295 NP_000279 301 QVADCSWDETIKIYDPACLTIPA 323 ||||||||||||||||.|||:|. NP_032848 296 QVADCSWDETIKIYDPVCLTVPG 318 #--------------------------------------- #--------------------------------------- >NP_000279.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|3122596|sp|O00628.1|PEX7_HUMAN RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|7157950|gb|AAF37350.1|AF180814_1 peroxisomal PTS2 receptor [Homo sapiens] >gi|1907315|gb|AAB50556.1| peroxisome targeting signal 2 receptor [Homo sapiens] >gi|1947088|gb|AAC51238.1| HsPex7p [Homo sapiens] >gi|13623328|gb|AAH06268.1| Peroxisomal biogenesis factor 7 [Homo sapiens] >gi|49457061|emb|CAG46851.1| PEX7 [Homo sapiens] >gi|49457105|emb|CAG46873.1| PEX7 [Homo sapiens] >gi|55957179|emb|CAI15471.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|55959581|emb|CAI15714.1| peroxisomal biogenesis factor 7 [Homo sapiens] >gi|60823463|gb|AAX36645.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|119568325|gb|EAW47940.1| peroxisomal biogenesis factor 7, isoform CRA_a [Homo sapiens] >gi|261861320|dbj|BAI47182.1| peroxisomal biogenesis factor 7 [synthetic construct] >gi|312151094|gb|ADQ32059.1| peroxisomal biogenesis factor 7 [synthetic construct] >NP_032848.1| peroxisomal biogenesis factor 7 isoform 1 [Mus musculus] >gi|3122602|sp|P97865.1|PEX7_MOUSE RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7 >gi|1890657|gb|AAB49755.1| peroxisomal PTS2 receptor [Mus musculus] >gi|124297903|gb|AAI32214.1| Peroxisomal biogenesis factor 7 [Mus musculus] >gi|124376084|gb|AAI32504.1| Peroxisomal biogenesis factor 7 [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:00 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000279 # 2: NP_032848 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 315 # Identity: 292/315 (92.7%) # Similarity: 302/315 (95.9%) # Gaps: 0/315 ( 0.0%) # Score: 1637.0 # # #======================================= NP_000279 8 AARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAG 57 |||.||.|||||||||||||||||||||.|||||||||||||:||.:|:| NP_032848 3 AARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLVLDQNESG 52 NP_000279 58 LRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVY 107 |::|||||||||||||||||||||||:||||||||||||||||.|||||| NP_032848 53 LQIFRSFDWNDGLFDVTWSENNEHVLVTCSGDGSLQLWDTAKATGPLQVY 102 NP_000279 108 KEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESI 157 |||.|||||||||||||||||||||||||||:||||||.||||||||||: NP_032848 103 KEHTQEVYSVDWSQTRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESV 152 NP_000279 158 IYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWC 207 |||||||||||||||||||||||||||||..||||||||||.|||||||| NP_032848 153 IYSTIWSPHIPGCFASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWC 202 NP_000279 208 KYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASV 257 ||||||:||||||||||||||||||||||||||||||||||||||||||| NP_032848 203 KYNENLVVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASV 252 NP_000279 258 LASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSW 307 |||||||||||||||||||.||||||||||||||||.||||||||||||| NP_032848 253 LASCSYDFTVRFWNFSKPDPLLETVEHHTEFTCGLDLSLQSPTQVADCSW 302 NP_000279 308 DETIKIYDPACLTIP 322 |||||||||.|||:| NP_032848 303 DETIKIYDPVCLTVP 317 #--------------------------------------- #--------------------------------------- >NP_000382.3| tripeptidyl-peptidase 1 preproprotein [Homo sapiens] >gi|108936017|sp|O14773.2|TPP1_HUMAN RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Cell growth-inhibiting gene 1 protein; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|19919858|gb|AAM08412.1|AF491290_1 tripeptidyl peptidase I [Bos taurus] >gi|4063841|gb|AAC98480.1| lysosomal pepstatin insensitive protease [Homo sapiens] >NP_034036.1| tripeptidyl-peptidase 1 precursor [Mus musculus] >gi|12644085|sp|O89023.2|TPP1_MOUSE RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|4894649|gb|AAD32573.1|AF124599_1 lysosomal pepstatin-insensitive protease [Mus musculus] >gi|4106913|gb|AAD03083.1| lysosomal pepstatin insensitive protease precursor [Mus musculus] >gi|12832387|dbj|BAB22085.1| unnamed protein product [Mus musculus] >gi|19353425|gb|AAH24820.1| Tripeptidyl peptidase I [Mus musculus] >gi|26339244|dbj|BAC33293.1| unnamed protein product [Mus musculus] >gi|74218095|dbj|BAE42026.1| unnamed protein product [Mus musculus] >gi|148684873|gb|EDL16820.1| tripeptidyl peptidase I, isoform CRA_c [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000382.3| MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVER NP_034036.1| MGLQARLLGLLALVIAGKCTYNPEPDQRWMLPPGWVSLGRVDPEEELSLTFALKQRNLER ***** **** ** *** * ****** ********** ************ * * ** NP_000382.3| LSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFL NP_034036.1| LSELVQAVSDPSSPQYGKYLTLEDVAELVQPSPLTLLTVQKWLSAAGARNCDSVTTQDFL *********************** ** ** ****** ****** **** * ** ***** NP_000382.3| TCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTS NP_034036.1| TCWLSVRQAELLLPGAEFHRYVGGPTKTHVIRSPHPYQLPQALAPHVDFVGGLHRFPP-S ***** ************* ****** *** *************************** * NP_000382.3| SLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDL NP_034036.1| SPRQRPEPQQVGTVSLHLGVTPSVLRQRYNLTAKDVGSGTTNNSQACAQFLEQYFHNSDL * ******* *** ********* * ***** ****** *************** *** NP_000382.3| AQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG NP_034036.1| TEFMRLFGGSFTHQASVAKVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEA ******* * ****** *** ************** ********************* NP_000382.3| QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGD NP_034036.1| QEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSIYIQRVNTEFMKAAARGLTLLFASGD ******** ****** ****************** ******** **************** NP_000382.3| SGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPS NP_034036.1| TGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLITDEVVDYISGGGFSNVFPRPP *********** *** **************** ***** * **************** NP_000382.3| YQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPV NP_034036.1| YQEEAVAQFLKSSSHLPPSSYFNASGRAYPDVAALSDGYWVVSNMVPIPWVSGTSASTPV ****** ** ** ****************************** *************** NP_000382.3| FGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGP NP_034036.1| FGGILSLINEHRILNGRPPLGFLNPRLYQQHGTGLFDVTHGCHESCLNEEVEGQGFCSGP ************** ***************** ****** ******* ************ NP_000382.3| GWDPVTGWGTPNFPALLKTLLNP NP_034036.1| GWDPVTGWGTPNFPALLKTLLNP *********************** >NP_000382.3| tripeptidyl-peptidase 1 preproprotein [Homo sapiens] >gi|108936017|sp|O14773.2|TPP1_HUMAN RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Cell growth-inhibiting gene 1 protein; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|19919858|gb|AAM08412.1|AF491290_1 tripeptidyl peptidase I [Bos taurus] >gi|4063841|gb|AAC98480.1| lysosomal pepstatin insensitive protease [Homo sapiens] >NP_034036.1| tripeptidyl-peptidase 1 precursor [Mus musculus] >gi|12644085|sp|O89023.2|TPP1_MOUSE RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|4894649|gb|AAD32573.1|AF124599_1 lysosomal pepstatin-insensitive protease [Mus musculus] >gi|4106913|gb|AAD03083.1| lysosomal pepstatin insensitive protease precursor [Mus musculus] >gi|12832387|dbj|BAB22085.1| unnamed protein product [Mus musculus] >gi|19353425|gb|AAH24820.1| Tripeptidyl peptidase I [Mus musculus] >gi|26339244|dbj|BAC33293.1| unnamed protein product [Mus musculus] >gi|74218095|dbj|BAE42026.1| unnamed protein product [Mus musculus] >gi|148684873|gb|EDL16820.1| tripeptidyl peptidase I, isoform CRA_c [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:01 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000382 # 2: NP_034036 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 563 # Identity: 497/563 (88.3%) # Similarity: 534/563 (94.8%) # Gaps: 1/563 ( 0.2%) # Score: 2686.0 # # #======================================= NP_000382 1 MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLT 50 |||||.||||.||:::|||:|:||||||..||||||||||.||||||||| NP_034036 1 MGLQARLLGLLALVIAGKCTYNPEPDQRWMLPPGWVSLGRVDPEEELSLT 50 NP_000382 51 FALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQ 100 |||:|:|:|||||||||||||||||||||||||:||:||:||||||.||| NP_034036 51 FALKQRNLERLSELVQAVSDPSSPQYGKYLTLEDVAELVQPSPLTLLTVQ 100 NP_000382 101 KWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHV 150 |||.||||:.|.||.||||||||||:|||||||||||||.||||||:||| NP_034036 101 KWLSAAGARNCDSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPTKTHV 150 NP_000382 151 VRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGV 200 :||||||||||||||||||||||||||| ||.|||||||..|||.||||| NP_034036 151 IRSPHPYQLPQALAPHVDFVGGLHRFPP-SSPRQRPEPQQVGTVSLHLGV 199 NP_000382 201 TPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGN 250 ||||:|:|||||::||||||:|||||||||||||||:|||.:|||||||: NP_034036 200 TPSVLRQRYNLTAKDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGGS 249 NP_000382 251 FAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG 300 |.||||||:|||:||||||||||||||:|||||||||||||||||||||. NP_034036 250 FTHQASVAKVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEA 299 NP_000382 301 QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAAR 350 ||||||||:||||||:||||||||||||||||||.||||||||.|||||| NP_034036 300 QEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSIYIQRVNTEFMKAAAR 349 NP_000382 351 GLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLIT 400 ||||||||||:|||||||||||:|||:||||||||||||||||:.||||| NP_034036 350 GLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLIT 399 NP_000382 401 NEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYP 450 :|:||||||||||||||||.||||||.:||.||.|||||||||||||||| NP_034036 400 DEVVDYISGGGFSNVFPRPPYQEEAVAQFLKSSSHLPPSSYFNASGRAYP 449 NP_000382 451 DVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPL 500 ||||||||||||||.|||||||||||||||||||||||||||||:||||| NP_034036 450 DVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRILNGRPPL 499 NP_000382 501 GFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGT 550 ||||||||||||.||||||.|||||||:|||||||||||||||||||||| NP_034036 500 GFLNPRLYQQHGTGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGT 549 NP_000382 551 PNFPALLKTLLNP 563 ||||||||||||| NP_034036 550 PNFPALLKTLLNP 562 #--------------------------------------- #--------------------------------------- >NP_000382.3| tripeptidyl-peptidase 1 preproprotein [Homo sapiens] >gi|108936017|sp|O14773.2|TPP1_HUMAN RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Cell growth-inhibiting gene 1 protein; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|19919858|gb|AAM08412.1|AF491290_1 tripeptidyl peptidase I [Bos taurus] >gi|4063841|gb|AAC98480.1| lysosomal pepstatin insensitive protease [Homo sapiens] >NP_034036.1| tripeptidyl-peptidase 1 precursor [Mus musculus] >gi|12644085|sp|O89023.2|TPP1_MOUSE RecName: Full=Tripeptidyl-peptidase 1; Short=TPP-1; AltName: Full=Lysosomal pepstatin-insensitive protease; Short=LPIC; AltName: Full=Tripeptidyl aminopeptidase; AltName: Full=Tripeptidyl-peptidase I; Short=TPP-I; Flags: Precursor >gi|4894649|gb|AAD32573.1|AF124599_1 lysosomal pepstatin-insensitive protease [Mus musculus] >gi|4106913|gb|AAD03083.1| lysosomal pepstatin insensitive protease precursor [Mus musculus] >gi|12832387|dbj|BAB22085.1| unnamed protein product [Mus musculus] >gi|19353425|gb|AAH24820.1| Tripeptidyl peptidase I [Mus musculus] >gi|26339244|dbj|BAC33293.1| unnamed protein product [Mus musculus] >gi|74218095|dbj|BAE42026.1| unnamed protein product [Mus musculus] >gi|148684873|gb|EDL16820.1| tripeptidyl peptidase I, isoform CRA_c [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:01 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000382 # 2: NP_034036 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 563 # Identity: 497/563 (88.3%) # Similarity: 534/563 (94.8%) # Gaps: 1/563 ( 0.2%) # Score: 2686.0 # # #======================================= NP_000382 1 MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLT 50 |||||.||||.||:::|||:|:||||||..||||||||||.||||||||| NP_034036 1 MGLQARLLGLLALVIAGKCTYNPEPDQRWMLPPGWVSLGRVDPEEELSLT 50 NP_000382 51 FALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQ 100 |||:|:|:|||||||||||||||||||||||||:||:||:||||||.||| NP_034036 51 FALKQRNLERLSELVQAVSDPSSPQYGKYLTLEDVAELVQPSPLTLLTVQ 100 NP_000382 101 KWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHV 150 |||.||||:.|.||.||||||||||:|||||||||||||.||||||:||| NP_034036 101 KWLSAAGARNCDSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPTKTHV 150 NP_000382 151 VRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGV 200 :||||||||||||||||||||||||||| ||.|||||||..|||.||||| NP_034036 151 IRSPHPYQLPQALAPHVDFVGGLHRFPP-SSPRQRPEPQQVGTVSLHLGV 199 NP_000382 201 TPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGN 250 ||||:|:|||||::||||||:|||||||||||||||:|||.:|||||||: NP_034036 200 TPSVLRQRYNLTAKDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGGS 249 NP_000382 251 FAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG 300 |.||||||:|||:||||||||||||||:|||||||||||||||||||||. NP_034036 250 FTHQASVAKVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEA 299 NP_000382 301 QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAAR 350 ||||||||:||||||:||||||||||||||||||.||||||||.|||||| NP_034036 300 QEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSIYIQRVNTEFMKAAAR 349 NP_000382 351 GLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLIT 400 ||||||||||:|||||||||||:|||:||||||||||||||||:.||||| NP_034036 350 GLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLIT 399 NP_000382 401 NEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYP 450 :|:||||||||||||||||.||||||.:||.||.|||||||||||||||| NP_034036 400 DEVVDYISGGGFSNVFPRPPYQEEAVAQFLKSSSHLPPSSYFNASGRAYP 449 NP_000382 451 DVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPL 500 ||||||||||||||.|||||||||||||||||||||||||||||:||||| NP_034036 450 DVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRILNGRPPL 499 NP_000382 501 GFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGT 550 ||||||||||||.||||||.|||||||:|||||||||||||||||||||| NP_034036 500 GFLNPRLYQQHGTGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGT 549 NP_000382 551 PNFPALLKTLLNP 563 ||||||||||||| NP_034036 550 PNFPALLKTLLNP 562 #--------------------------------------- #--------------------------------------- >NP_000392.3| exostosin-2 isoform 1 [Homo sapiens] >gi|119588477|gb|EAW68071.1| exostoses (multiple) 2, isoform CRA_d [Homo sapiens] >NP_034293.2| exostosin-2 [Mus musculus] >gi|341940670|sp|P70428.2|EXT2_MOUSE RecName: Full=Exostosin-2; AltName: Full=Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; AltName: Full=Multiple exostoses protein 2 homolog >gi|74216635|dbj|BAE37749.1| unnamed protein product [Mus musculus] >gi|123228761|emb|CAM23881.1| exostoses (multiple) 2 [Mus musculus] >gi|123228772|emb|CAM22097.1| exostoses (multiple) 2 [Mus musculus] >gi|148695682|gb|EDL27629.1| exostoses (multiple) 2, isoform CRA_a [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000392.3| MSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYI NP_034293.2| ---------------------------------MCASVKSNIRGPALIPRMKTKHRIYYV ****** ******************* NP_000392.3| TLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRM NP_034293.2| TLFSIVLLGLIATGMFQFWPHSIESSSDGGVEKRSIREVPVVRLPTDSPIPERGDLSCRM ************************** * ******* ******* ************** NP_000392.3| HTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDI NP_034293.2| HTCFDVYRCGFNPKNKIKVYIYPLKKYVDDAGVPVSSAISREYNELLTAISDSDYYTDDI ********************** ******* ** ** ********* ************ NP_000392.3| NRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPR NP_034293.2| NRACLFVPSIDVLNQNPLRIKETAQALAQLSRWDRGTNHLLFNMLPGAPPDYNTALDVPR **************** ********* ******************** ************ NP_000392.3| DRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYRE NP_034293.2| DRALLAGGGFSTWTYRQGYDVSIPVFSPLSAEMALPEKAPGPRRYFLLSSQMAIHPEYRE ************************* ****** **** **** ******* ****** NP_000392.3| DLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLG NP_034293.2| ELEALQAKHQESVLVLDKCTNLSEGVLSVRKRCHQHQVFDYPQVLQEATFCTVLRGARLG ***** ** ************************ **************** ******** NP_000392.3| QAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEE NP_034293.2| QAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQNIPQRQIEE *************************************************** ******** NP_000392.3| MQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLP NP_034293.2| MQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWASVSNPLFLP ************************************************** ********* NP_000392.3| LIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV NP_034293.2| LIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRV *************************************************** ******** NP_000392.3| PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP NP_034293.2| PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP ************************************************************ NP_000392.3| GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCE NP_034293.2| GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDTHMNCE ****************************************************** ***** NP_000392.3| DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM NP_034293.2| DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM ************************************************************ NP_000392.3| PLKVVEHRADPVLYKDDFPEKLKSFPNIGSL NP_034293.2| PLKVVEHRADPVLYKDDFPEKLKSFPNIGSL ******************************* >NP_000392.3| exostosin-2 isoform 1 [Homo sapiens] >gi|119588477|gb|EAW68071.1| exostoses (multiple) 2, isoform CRA_d [Homo sapiens] >NP_034293.2| exostosin-2 [Mus musculus] >gi|341940670|sp|P70428.2|EXT2_MOUSE RecName: Full=Exostosin-2; AltName: Full=Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; AltName: Full=Multiple exostoses protein 2 homolog >gi|74216635|dbj|BAE37749.1| unnamed protein product [Mus musculus] >gi|123228761|emb|CAM23881.1| exostoses (multiple) 2 [Mus musculus] >gi|123228772|emb|CAM22097.1| exostoses (multiple) 2 [Mus musculus] >gi|148695682|gb|EDL27629.1| exostoses (multiple) 2, isoform CRA_a [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:01 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000392 # 2: NP_034293 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 751 # Identity: 685/751 (91.2%) # Similarity: 699/751 (93.1%) # Gaps: 33/751 ( 4.4%) # Score: 3645.0 # # #======================================= NP_000392 1 MSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPR 50 ||||||.|||||||||| NP_034293 1 ---------------------------------MCASVKSNIRGPALIPR 17 NP_000392 51 MKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVP 100 |||||||||:||||||||||||||||||||||||||:|..|||||||:|| NP_034293 18 MKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSIESSSDGGVEKRSIREVP 67 NP_000392 101 VVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDD 150 |||||.||||||||||||||||||||||||||||||||||||.||||||| NP_034293 68 VVRLPTDSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDD 117 NP_000392 151 FGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVLNQNTLRI 200 .||.||:.|||||||||.||||||||||||||||||||||||||||.||| NP_034293 118 AGVPVSSAISREYNELLTAISDSDYYTDDINRACLFVPSIDVLNQNPLRI 167 NP_000392 201 KETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGF 250 ||||||:||||||||||||||||||||.|||||||||||||||||||||| NP_034293 168 KETAQALAQLSRWDRGTNHLLFNMLPGAPPDYNTALDVPRDRALLAGGGF 217 NP_000392 251 STWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYRE 300 |||||||||||||||:||||||:.||||.||||:|||||||:.:|||||| NP_034293 218 STWTYRQGYDVSIPVFSPLSAEMALPEKAPGPRRYFLLSSQMAIHPEYRE 267 NP_000392 301 DLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATF 350 :|||||.||.||||||||||||||||||||||||:||||||||||||||| NP_034293 268 ELEALQAKHQESVLVLDKCTNLSEGVLSVRKRCHQHQVFDYPQVLQEATF 317 NP_000392 351 CVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPE 400 |.|||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 318 CTVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPE 367 NP_000392 401 EKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDR 450 |||||||||||:|||||||||||||||||||||||||||||||||||||| NP_034293 368 EKMSDVYSILQNIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDR 417 NP_000392 451 IYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVE 500 ||||||||||||||||||||.||||||||||||||||||||||||||||| NP_034293 418 IYPYAAISYEEWNDPPAVKWASVSNPLFLPLIPPQSQGFTAIVLTYDRVE 467 NP_000392 501 SLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAEN 550 |||||||||||||||||||||||||||||||:|||||||||||||||||| NP_034293 468 SLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVVRTAEN 517 NP_000392 551 KLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP 600 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 518 KLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP 567 NP_000392 601 GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIK 650 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 568 GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIK 617 NP_000392 651 NWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQ 700 ||||.||||||||||||||||||||||||||||||||||||||||||||| NP_034293 618 NWVDTHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQ 667 NP_000392 701 THMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGS 750 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 668 THMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGS 717 NP_000392 751 L 751 | NP_034293 718 L 718 #--------------------------------------- #--------------------------------------- >NP_000392.3| exostosin-2 isoform 1 [Homo sapiens] >gi|119588477|gb|EAW68071.1| exostoses (multiple) 2, isoform CRA_d [Homo sapiens] >NP_034293.2| exostosin-2 [Mus musculus] >gi|341940670|sp|P70428.2|EXT2_MOUSE RecName: Full=Exostosin-2; AltName: Full=Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; AltName: Full=Multiple exostoses protein 2 homolog >gi|74216635|dbj|BAE37749.1| unnamed protein product [Mus musculus] >gi|123228761|emb|CAM23881.1| exostoses (multiple) 2 [Mus musculus] >gi|123228772|emb|CAM22097.1| exostoses (multiple) 2 [Mus musculus] >gi|148695682|gb|EDL27629.1| exostoses (multiple) 2, isoform CRA_a [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:01 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000392 # 2: NP_034293 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 718 # Identity: 685/718 (95.4%) # Similarity: 699/718 (97.4%) # Gaps: 0/718 ( 0.0%) # Score: 3645.0 # # #======================================= NP_000392 34 MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSI 83 ||||||.|||||||||||||||||||:||||||||||||||||||||||| NP_034293 1 MCASVKSNIRGPALIPRMKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSI 50 NP_000392 84 ESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNP 133 |||:|..|||||||:|||||||.||||||||||||||||||||||||||| NP_034293 51 ESSSDGGVEKRSIREVPVVRLPTDSPIPERGDLSCRMHTCFDVYRCGFNP 100 NP_000392 134 KNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRA 183 |||||||||.|||||||.||.||:.|||||||||.||||||||||||||| NP_034293 101 KNKIKVYIYPLKKYVDDAGVPVSSAISREYNELLTAISDSDYYTDDINRA 150 NP_000392 184 CLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYN 233 |||||||||||||.|||||||||:||||||||||||||||||||.||||| NP_034293 151 CLFVPSIDVLNQNPLRIKETAQALAQLSRWDRGTNHLLFNMLPGAPPDYN 200 NP_000392 234 TALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR 283 ||||||||||||||||||||||||||||||||:||||||:.||||.|||| NP_034293 201 TALDVPRDRALLAGGGFSTWTYRQGYDVSIPVFSPLSAEMALPEKAPGPR 250 NP_000392 284 QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRC 333 :|||||||:.:||||||:|||||.||.||||||||||||||||||||||| NP_034293 251 RYFLLSSQMAIHPEYREELEALQAKHQESVLVLDKCTNLSEGVLSVRKRC 300 NP_000392 334 HKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVVIADSYIL 383 |:||||||||||||||||.||||||||||||||||||||||||||||||| NP_034293 301 HQHQVFDYPQVLQEATFCTVLRGARLGQAVLSDVLQAGCVPVVIADSYIL 350 NP_000392 384 PFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYF 433 ||||||||||||||||||||||||||||:||||||||||||||||||||| NP_034293 351 PFSEVLDWKRASVVVPEEKMSDVYSILQNIPQRQIEEMQRQARWFWEAYF 400 NP_000392 434 QSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIP 483 |||||||||||||||||||||||||||||||||||||.|||||||||||| NP_034293 401 QSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWASVSNPLFLPLIP 450 NP_000392 484 PQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDS 533 ||||||||||||||||||||||||||||||||||||||||||||||||:| NP_034293 451 PQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEES 500 NP_000392 534 LWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQ 583 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 501 LWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQ 550 NP_000392 584 FGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFY 633 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 551 FGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFY 600 NP_000392 634 HKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRK 683 |||||||||||||||||||||.|||||||||||||||||||||||||||| NP_034293 601 HKYFNYLYTYKMPGDIKNWVDTHMNCEDIAMNFLVANVTGKAVIKVTPRK 650 NP_000392 684 KFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVL 733 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_034293 651 KFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVL 700 NP_000392 734 YKDDFPEKLKSFPNIGSL 751 |||||||||||||||||| NP_034293 701 YKDDFPEKLKSFPNIGSL 718 #--------------------------------------- #--------------------------------------- >NP_000397.1| gonadotropin-releasing hormone receptor isoform 1 [Homo sapiens] >gi|399777|sp|P30968.1|GNRHR_HUMAN RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|183422|gb|AAA35918.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|292053|gb|AAA35917.1| GnRH receptor [Homo sapiens] >gi|299701|gb|AAB26287.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|957293|gb|AAB33884.1| gonadotropin releasing hormone receptor, partial [Homo sapiens] >gi|2290768|gb|AAB71348.1| gonadotropin releasing hormone receptor [Homo sapiens] >gi|40807648|gb|AAR92228.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|109731732|gb|AAI13547.1| Gonadotropin-releasing hormone receptor [Homo sapiens] >gi|119625963|gb|EAX05558.1| gonadotropin-releasing hormone receptor, isoform CRA_b [Homo sapiens] >gi|313883306|gb|ADR83139.1| gonadotropin-releasing hormone receptor [synthetic construct] >gi|449617|prf||1919393A luliberin receptor >gi|1093746|prf||2104384A luliberin receptor >NP_034453.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|399778|sp|Q01776.1|GNRHR_MOUSE RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|193634|gb|AAB59636.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|148706011|gb|EDL37958.1| gonadotropin releasing hormone receptor, isoform CRA_b [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000397.1| MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL NP_034453.1| MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKL *** ** ** ************ ** ***** **************** ********* NP_000397.1| QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL NP_034453.1| QKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL ****** ********* ********************************* ******** NP_000397.1| KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM NP_034453.1| KLFSMYAPAFMMVVISLDRSLAITQPLAVQSNSKLEQSMISLAWILSIVFAGPQLYIFRM ************************ *** **** *** ****** ************ NP_000397.1| IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR NP_034453.1| IYLADGSGPTVF-SQCVTHCSFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTR * *** ** * ********* ************* ******* *********** *** NP_000397.1| VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL NP_034453.1| VLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRV ****** *************** ************ ********************** NP_000397.1| SDPVNHFFFLFAFLNPCFDPLIYGYFSL NP_034453.1| SEPVNHFFFLFAFLNPCFDPLIYGYFSL * ************************** >NP_000397.1| gonadotropin-releasing hormone receptor isoform 1 [Homo sapiens] >gi|399777|sp|P30968.1|GNRHR_HUMAN RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|183422|gb|AAA35918.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|292053|gb|AAA35917.1| GnRH receptor [Homo sapiens] >gi|299701|gb|AAB26287.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|957293|gb|AAB33884.1| gonadotropin releasing hormone receptor, partial [Homo sapiens] >gi|2290768|gb|AAB71348.1| gonadotropin releasing hormone receptor [Homo sapiens] >gi|40807648|gb|AAR92228.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|109731732|gb|AAI13547.1| Gonadotropin-releasing hormone receptor [Homo sapiens] >gi|119625963|gb|EAX05558.1| gonadotropin-releasing hormone receptor, isoform CRA_b [Homo sapiens] >gi|313883306|gb|ADR83139.1| gonadotropin-releasing hormone receptor [synthetic construct] >gi|449617|prf||1919393A luliberin receptor >gi|1093746|prf||2104384A luliberin receptor >NP_034453.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|399778|sp|Q01776.1|GNRHR_MOUSE RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|193634|gb|AAB59636.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|148706011|gb|EDL37958.1| gonadotropin releasing hormone receptor, isoform CRA_b [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:02 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000397 # 2: NP_034453 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 328 # Identity: 293/328 (89.3%) # Similarity: 310/328 (94.5%) # Gaps: 1/328 ( 0.3%) # Score: 1559.0 # # #======================================= NP_000397 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSA 50 |||:||.||:.||||||||||||:||.|||||:||||||||||||||||. NP_034453 1 MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLST 50 NP_000397 51 TFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGM 100 .|||||||||||||||::|||||||||:|||||||||||||||||||||| NP_034453 51 AFNASFLLKLQKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGM 100 NP_000397 101 WNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALK 150 |||||||||||.||||||||||||||||||||||||||||||||:|||:: NP_034453 101 WNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPLAVQ 150 NP_000397 151 SNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHC 200 ||||:.|||:.||||||.|||||||||||||:|||.||.| ||||||||| NP_034453 151 SNSKLEQSMISLAWILSIVFAGPQLYIFRMIYLADGSGPT-VFSQCVTHC 199 NP_000397 201 SFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQ 250 ||.|||||||||||||.|||||||.|||||||||||.|||||||||.:|| NP_034453 200 SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQ 249 NP_000397 251 LNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL 300 |||||||||||||:||||||||||||.||||||||||||||||||||||: NP_034453 250 LNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRV 299 NP_000397 301 SDPVNHFFFLFAFLNPCFDPLIYGYFSL 328 |:|||||||||||||||||||||||||| NP_034453 300 SEPVNHFFFLFAFLNPCFDPLIYGYFSL 327 #--------------------------------------- #--------------------------------------- >NP_000397.1| gonadotropin-releasing hormone receptor isoform 1 [Homo sapiens] >gi|399777|sp|P30968.1|GNRHR_HUMAN RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|183422|gb|AAA35918.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|292053|gb|AAA35917.1| GnRH receptor [Homo sapiens] >gi|299701|gb|AAB26287.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|957293|gb|AAB33884.1| gonadotropin releasing hormone receptor, partial [Homo sapiens] >gi|2290768|gb|AAB71348.1| gonadotropin releasing hormone receptor [Homo sapiens] >gi|40807648|gb|AAR92228.1| gonadotropin-releasing hormone receptor [Homo sapiens] >gi|109731732|gb|AAI13547.1| Gonadotropin-releasing hormone receptor [Homo sapiens] >gi|119625963|gb|EAX05558.1| gonadotropin-releasing hormone receptor, isoform CRA_b [Homo sapiens] >gi|313883306|gb|ADR83139.1| gonadotropin-releasing hormone receptor [synthetic construct] >gi|449617|prf||1919393A luliberin receptor >gi|1093746|prf||2104384A luliberin receptor >NP_034453.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|399778|sp|Q01776.1|GNRHR_MOUSE RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R >gi|193634|gb|AAB59636.1| gonadotropin-releasing hormone receptor [Mus musculus] >gi|148706011|gb|EDL37958.1| gonadotropin releasing hormone receptor, isoform CRA_b [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:02 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000397 # 2: NP_034453 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 328 # Identity: 293/328 (89.3%) # Similarity: 310/328 (94.5%) # Gaps: 1/328 ( 0.3%) # Score: 1559.0 # # #======================================= NP_000397 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSA 50 |||:||.||:.||||||||||||:||.|||||:||||||||||||||||. NP_034453 1 MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLST 50 NP_000397 51 TFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGM 100 .|||||||||||||||::|||||||||:|||||||||||||||||||||| NP_034453 51 AFNASFLLKLQKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGM 100 NP_000397 101 WNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALK 150 |||||||||||.||||||||||||||||||||||||||||||||:|||:: NP_034453 101 WNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPLAVQ 150 NP_000397 151 SNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHC 200 ||||:.|||:.||||||.|||||||||||||:|||.||.| ||||||||| NP_034453 151 SNSKLEQSMISLAWILSIVFAGPQLYIFRMIYLADGSGPT-VFSQCVTHC 199 NP_000397 201 SFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQ 250 ||.|||||||||||||.|||||||.|||||||||||.|||||||||.:|| NP_034453 200 SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQ 249 NP_000397 251 LNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL 300 |||||||||||||:||||||||||||.||||||||||||||||||||||: NP_034453 250 LNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRV 299 NP_000397 301 SDPVNHFFFLFAFLNPCFDPLIYGYFSL 328 |:|||||||||||||||||||||||||| NP_034453 300 SEPVNHFFFLFAFLNPCFDPLIYGYFSL 327 #--------------------------------------- #--------------------------------------- >NP_000405.1| peroxisomal multifunctional enzyme type 2 isoform 2 [Homo sapiens] >gi|1706396|sp|P51659.3|DHB4_HUMAN RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|1050517|emb|CAA60643.1| 17beta-hydroxysteroid dehydrogenase [Homo sapiens] >gi|4165049|gb|AAD08652.1| 17-beta-hydroxysteroid dehydrogenase IV [Homo sapiens] >gi|13111861|gb|AAH03098.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] >gi|119569296|gb|EAW48911.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b [Homo sapiens] >gi|123981926|gb|ABM82792.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >gi|123996759|gb|ABM85981.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >NP_032318.2| peroxisomal multifunctional enzyme type 2 [Mus musculus] >gi|94730372|sp|P51660.3|DHB4_MOUSE RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|12836373|dbj|BAB23627.1| unnamed protein product [Mus musculus] >gi|18380947|gb|AAH22175.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Mus musculus] >gi|26353374|dbj|BAC40317.1| unnamed protein product [Mus musculus] >gi|74139444|dbj|BAE40862.1| unnamed protein product [Mus musculus] >gi|74177890|dbj|BAE39029.1| unnamed protein product [Mus musculus] >gi|74188898|dbj|BAE39222.1| unnamed protein product [Mus musculus] >gi|148677989|gb|EDL09936.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_d [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_000405.1| MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE NP_032318.2| MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGKGSSAADKVVA * **************** ***************** ********** **** ****** NP_000405.1| EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH NP_032318.2| EIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIH **** ************ *** ****** ******************* *********** NP_000405.1| RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI NP_032318.2| RVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFGQANYSAAKLGILGLCNTLAI *************** ***** **** *********************** *** * *** NP_000405.1| EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG NP_032318.2| EGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG **** **************** ** *********************************** NP_000405.1| AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS NP_032318.2| AGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLH ****************** * ******* ** ***** ****** ****** * *** NP_000405.1| KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD NP_032318.2| KVDSEGISPNRTSHAAPA-ATSGFVGAVGHKLPSFSSSYTELQSIMYALGVGASVKNPKD * **** * ***** ** * *** ** **** ********** * *** NP_000405.1| LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA NP_032318.2| LKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVPGLSFNFAKALHGEQYLELYKPLPRS *** **** *********** ***** ***** **** **** *************** NP_000405.1| GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV NP_032318.2| GELKCEAVIADILDKGSGVVIVMDVYSYSGKELICYNQFSVFVVGSGGFGGKRTSEKLKA * ****** ** ********* ******* ***** **** * ************ * * NP_000405.1| AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS NP_032318.2| AVAVPNRPPDAVLRDATSLNQAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFS *** ********* * ********************** *** *** ************* NP_000405.1| ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN NP_032318.2| ARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISN ** ***************** ***************************** **** **** NP_000405.1| AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI NP_032318.2| AYVDLVPASGVSTQTPSEGGELQSALVFGEIGRRLKSVGREVVKKANAVFEWHITKGGTV ***** * ** * ****** *** ** ******* * ***** ************ NP_000405.1| GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI NP_032318.2| AAKWTIDLKSGSGEVYQGPAKGSADVTIIISDEDFMEVVFGKLDPQKAFFSGRLKARGNI ************ ******** ** *** ********* ******************** NP_000405.1| MLSQKLQMILKDYAKL NP_032318.2| MLSQKLQMILKDYAKL **************** >NP_000405.1| peroxisomal multifunctional enzyme type 2 isoform 2 [Homo sapiens] >gi|1706396|sp|P51659.3|DHB4_HUMAN RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|1050517|emb|CAA60643.1| 17beta-hydroxysteroid dehydrogenase [Homo sapiens] >gi|4165049|gb|AAD08652.1| 17-beta-hydroxysteroid dehydrogenase IV [Homo sapiens] >gi|13111861|gb|AAH03098.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] >gi|119569296|gb|EAW48911.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b [Homo sapiens] >gi|123981926|gb|ABM82792.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >gi|123996759|gb|ABM85981.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >NP_032318.2| peroxisomal multifunctional enzyme type 2 [Mus musculus] >gi|94730372|sp|P51660.3|DHB4_MOUSE RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|12836373|dbj|BAB23627.1| unnamed protein product [Mus musculus] >gi|18380947|gb|AAH22175.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Mus musculus] >gi|26353374|dbj|BAC40317.1| unnamed protein product [Mus musculus] >gi|74139444|dbj|BAE40862.1| unnamed protein product [Mus musculus] >gi|74177890|dbj|BAE39029.1| unnamed protein product [Mus musculus] >gi|74188898|dbj|BAE39222.1| unnamed protein product [Mus musculus] >gi|148677989|gb|EDL09936.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_d [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:02 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000405 # 2: NP_032318 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 736 # Identity: 635/736 (86.3%) # Similarity: 687/736 (93.3%) # Gaps: 1/736 ( 0.1%) # Score: 3385.0 # # #======================================= NP_000405 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGK 50 |.||||||||||||||||.|||||||||||||||||:||||||||||:|| NP_032318 1 MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGK 50 NP_000405 51 GSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNA 100 ||.||||||.||||:||||||||||||.|||:||||||.||||||||||| NP_032318 51 GSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNA 100 NP_000405 101 GILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTS 150 ||||||||:||||||||||||||||||||||||||:|||||.||||:||| NP_032318 101 GILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTS 150 NP_000405 151 SASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRM 200 ||||||||||||||||||||:|||.|:|||||||:||||||||||||||| NP_032318 151 SASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRM 200 NP_000405 201 TQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWE 250 |:||:||||||||||||||||||||||||||||||||||||||||||||| NP_032318 201 TETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWE 250 NP_000405 251 RTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS 300 ||||||||::|.|||||||:.||:|||||.||||||:||||||.|:|||. NP_032318 251 RTLGAIVRKRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLH 300 NP_000405 301 KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALG 350 |:||| |:|.|.||.|...|||||.||:|.|||.||.:||||::|||||| NP_032318 301 KVDSE-GISPNRTSHAAPAATSGFVGAVGHKLPSFSSSYTELQSIMYALG 349 NP_000405 351 VGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSIN 400 ||||:|:||||||:||||:|||||||||||:.|||||.|||||:||||.| NP_032318 350 VGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVPGLSFN 399 NP_000405 401 FAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSE 450 |||.|||||||||||||||:|:||||||:||:|||||||||:|||||||. NP_032318 400 FAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSYSG 449 NP_000405 451 KELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLN 500 |||||:||||:|:||||||||||||:|:|.|||:|||||||||.|.|||| NP_032318 450 KELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLN 499 NP_000405 501 QAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFAD 550 ||||||||||||||||||:|||:|||:|||||||||||||||.||||||| NP_032318 500 QAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFAD 549 NP_000405 551 NDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN 600 ||||||||||.|||||||||||||||||||||||||||||.||||:|||| NP_032318 550 NDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISN 599 NP_000405 601 AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVF 650 |||||.|.||.|.:||||||:|||..||.|||||||.:|.|||||.|||| NP_032318 600 AYVDLVPASGVSTQTPSEGGELQSALVFGEIGRRLKSVGREVVKKANAVF 649 NP_000405 651 EWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVL 700 ||||||||.:.||||||||||||:||||||||:||.|||:|||||||||. NP_032318 650 EWHITKGGTVAAKWTIDLKSGSGEVYQGPAKGSADVTIIISDEDFMEVVF 699 NP_000405 701 GKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 736 |||||||||||||||||||||||||||||||||||| NP_032318 700 GKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 735 #--------------------------------------- #--------------------------------------- >NP_000405.1| peroxisomal multifunctional enzyme type 2 isoform 2 [Homo sapiens] >gi|1706396|sp|P51659.3|DHB4_HUMAN RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|1050517|emb|CAA60643.1| 17beta-hydroxysteroid dehydrogenase [Homo sapiens] >gi|4165049|gb|AAD08652.1| 17-beta-hydroxysteroid dehydrogenase IV [Homo sapiens] >gi|13111861|gb|AAH03098.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] >gi|119569296|gb|EAW48911.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b [Homo sapiens] >gi|123981926|gb|ABM82792.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >gi|123996759|gb|ABM85981.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct] >NP_032318.2| peroxisomal multifunctional enzyme type 2 [Mus musculus] >gi|94730372|sp|P51660.3|DHB4_MOUSE RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase >gi|12836373|dbj|BAB23627.1| unnamed protein product [Mus musculus] >gi|18380947|gb|AAH22175.1| Hydroxysteroid (17-beta) dehydrogenase 4 [Mus musculus] >gi|26353374|dbj|BAC40317.1| unnamed protein product [Mus musculus] >gi|74139444|dbj|BAE40862.1| unnamed protein product [Mus musculus] >gi|74177890|dbj|BAE39029.1| unnamed protein product [Mus musculus] >gi|74188898|dbj|BAE39222.1| unnamed protein product [Mus musculus] >gi|148677989|gb|EDL09936.1| hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_d [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:02 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000405 # 2: NP_032318 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 736 # Identity: 635/736 (86.3%) # Similarity: 687/736 (93.3%) # Gaps: 1/736 ( 0.1%) # Score: 3385.0 # # #======================================= NP_000405 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGK 50 |.||||||||||||||||.|||||||||||||||||:||||||||||:|| NP_032318 1 MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGK 50 NP_000405 51 GSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNA 100 ||.||||||.||||:||||||||||||.|||:||||||.||||||||||| NP_032318 51 GSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNA 100 NP_000405 101 GILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTS 150 ||||||||:||||||||||||||||||||||||||:|||||.||||:||| NP_032318 101 GILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTS 150 NP_000405 151 SASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRM 200 ||||||||||||||||||||:|||.|:|||||||:||||||||||||||| NP_032318 151 SASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRM 200 NP_000405 201 TQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWE 250 |:||:||||||||||||||||||||||||||||||||||||||||||||| NP_032318 201 TETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWE 250 NP_000405 251 RTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS 300 ||||||||::|.|||||||:.||:|||||.||||||:||||||.|:|||. NP_032318 251 RTLGAIVRKRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLH 300 NP_000405 301 KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALG 350 |:||| |:|.|.||.|...|||||.||:|.|||.||.:||||::|||||| NP_032318 301 KVDSE-GISPNRTSHAAPAATSGFVGAVGHKLPSFSSSYTELQSIMYALG 349 NP_000405 351 VGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSIN 400 ||||:|:||||||:||||:|||||||||||:.|||||.|||||:||||.| NP_032318 350 VGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVPGLSFN 399 NP_000405 401 FAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSE 450 |||.|||||||||||||||:|:||||||:||:|||||||||:|||||||. NP_032318 400 FAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSYSG 449 NP_000405 451 KELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLN 500 |||||:||||:|:||||||||||||:|:|.|||:|||||||||.|.|||| NP_032318 450 KELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLN 499 NP_000405 501 QAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFAD 550 ||||||||||||||||||:|||:|||:|||||||||||||||.||||||| NP_032318 500 QAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFAD 549 NP_000405 551 NDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN 600 ||||||||||.|||||||||||||||||||||||||||||.||||:|||| NP_032318 550 NDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISN 599 NP_000405 601 AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVF 650 |||||.|.||.|.:||||||:|||..||.|||||||.:|.|||||.|||| NP_032318 600 AYVDLVPASGVSTQTPSEGGELQSALVFGEIGRRLKSVGREVVKKANAVF 649 NP_000405 651 EWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVL 700 ||||||||.:.||||||||||||:||||||||:||.|||:|||||||||. NP_032318 650 EWHITKGGTVAAKWTIDLKSGSGEVYQGPAKGSADVTIIISDEDFMEVVF 699 NP_000405 701 GKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 736 |||||||||||||||||||||||||||||||||||| NP_032318 700 GKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 735 #--------------------------------------- #--------------------------------------- >NP_000536.5| hepatocyte nuclear factor 1-alpha [Homo sapiens] >gi|51338763|sp|P20823.2|HNF1A_HUMAN RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 >gi|119618632|gb|EAW98226.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor, isoform CRA_a [Homo sapiens] >gi|148733228|gb|ABR09270.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor [Homo sapiens] >NP_033353.2| hepatocyte nuclear factor 1-alpha [Mus musculus] >gi|341940804|sp|P22361.2|HNF1A_MOUSE RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 CLUSTAL 2.0.12 multiple sequence alignment NP_000536.5| MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL NP_033353.2| MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTEL ************************************* ************* ** * ** NP_000536.5| PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK NP_033353.2| PNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVK ************ ******** *********************** ************** NP_000536.5| SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA NP_033353.2| SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA ************************************************************ NP_000536.5| GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE NP_033353.2| GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE ************************************************************ NP_000536.5| CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP NP_033353.2| CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP ********************************************** ************* NP_000536.5| AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH NP_033353.2| AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSS ******** ************* **** *************** ************ NP_000536.5| SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA NP_033353.2| LL-STEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA * ********* *********************************************** NP_000536.5| SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV NP_033353.2| SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV ************************************************************ NP_000536.5| QSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK NP_033353.2| QSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNL-STLASLTPTK **** ****************************** *********** * ******** NP_000536.5| QVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS NP_033353.2| QVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQS ************ *** * * *** * ***** *********** ************** NP_000536.5| SDSSNGQSHLLPSNHSVIETFISTQMASSSQ NP_033353.2| SDSNGH-SHLLPSNHSVIETFISTQMASSSQ *** ************************ >NP_000536.5| hepatocyte nuclear factor 1-alpha [Homo sapiens] >gi|51338763|sp|P20823.2|HNF1A_HUMAN RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 >gi|119618632|gb|EAW98226.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor, isoform CRA_a [Homo sapiens] >gi|148733228|gb|ABR09270.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor [Homo sapiens] >NP_033353.2| hepatocyte nuclear factor 1-alpha [Mus musculus] >gi|341940804|sp|P22361.2|HNF1A_MOUSE RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:03 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000536 # 2: NP_033353 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 631 # Identity: 598/631 (94.8%) # Similarity: 606/631 (96.0%) # Gaps: 3/631 ( 0.5%) # Score: 3064.0 # # #======================================= NP_000536 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESC 50 |||||||||||||||||||||||||||||||||||||:.||||||||||| NP_033353 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESC 50 NP_000536 51 GGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQ 100 ||.||:|.||||||||||||||:||||||||.|||||||||||||||||| NP_033353 51 GGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQ 100 NP_000536 101 KAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNK 150 |||||:|||||||||||||||||||||||||||||||||||||||||||| NP_033353 101 KAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNK 150 NP_000536 151 GTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGR 200 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 151 GTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGR 200 NP_000536 201 RNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQ 250 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 201 RNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQ 250 NP_000536 251 AQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP 300 ||||||||||||||||||||||||||||||||||||:||||||||||||| NP_033353 251 AQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP 300 NP_000536 301 AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQ 350 ||||||||...|||||||||||||.||||.|||||||||||||||..||| NP_033353 301 AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQ 350 NP_000536 351 VSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQP 400 ||||||||| ||||||||||||.||||||||||||||||||||||||||| NP_033353 351 VSPTGLEPS-SLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQP 399 NP_000536 401 QNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN 450 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 400 QNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN 449 NP_000536 451 SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPH 500 ||||||||||||||||||||||||||||||||||.||||||||||||||| NP_033353 450 SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPH 499 NP_000536 501 ALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEAS 550 |||||||||||||||.|||||||||| ||||.|||||||||||||||||| NP_033353 500 ALYSHKPEVAQYTHTSLLPQTMLITD-TNLSTLASLTPTKQVFTSDTEAS 548 NP_000536 551 SESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS 600 ||.|||.|.|.|||:|:|||||:.|||||||||||.|||||||||||||| NP_033353 549 SEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQS 598 NP_000536 601 SDSSNGQSHLLPSNHSVIETFISTQMASSSQ 631 || |||.|||||||||||||||||||||||| NP_033353 599 SD-SNGHSHLLPSNHSVIETFISTQMASSSQ 628 #--------------------------------------- #--------------------------------------- >NP_000536.5| hepatocyte nuclear factor 1-alpha [Homo sapiens] >gi|51338763|sp|P20823.2|HNF1A_HUMAN RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 >gi|119618632|gb|EAW98226.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor, isoform CRA_a [Homo sapiens] >gi|148733228|gb|ABR09270.1| transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor [Homo sapiens] >NP_033353.2| hepatocyte nuclear factor 1-alpha [Mus musculus] >gi|341940804|sp|P22361.2|HNF1A_MOUSE RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1 ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:03 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_000536 # 2: NP_033353 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 631 # Identity: 598/631 (94.8%) # Similarity: 606/631 (96.0%) # Gaps: 3/631 ( 0.5%) # Score: 3064.0 # # #======================================= NP_000536 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESC 50 |||||||||||||||||||||||||||||||||||||:.||||||||||| NP_033353 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESC 50 NP_000536 51 GGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQ 100 ||.||:|.||||||||||||||:||||||||.|||||||||||||||||| NP_033353 51 GGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQ 100 NP_000536 101 KAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNK 150 |||||:|||||||||||||||||||||||||||||||||||||||||||| NP_033353 101 KAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNK 150 NP_000536 151 GTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGR 200 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 151 GTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGR 200 NP_000536 201 RNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQ 250 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 201 RNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQ 250 NP_000536 251 AQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP 300 ||||||||||||||||||||||||||||||||||||:||||||||||||| NP_033353 251 AQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP 300 NP_000536 301 AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQ 350 ||||||||...|||||||||||||.||||.|||||||||||||||..||| NP_033353 301 AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQ 350 NP_000536 351 VSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQP 400 ||||||||| ||||||||||||.||||||||||||||||||||||||||| NP_033353 351 VSPTGLEPS-SLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQP 399 NP_000536 401 QNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN 450 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_033353 400 QNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN 449 NP_000536 451 SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPH 500 ||||||||||||||||||||||||||||||||||.||||||||||||||| NP_033353 450 SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPH 499 NP_000536 501 ALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEAS 550 |||||||||||||||.|||||||||| ||||.|||||||||||||||||| NP_033353 500 ALYSHKPEVAQYTHTSLLPQTMLITD-TNLSTLASLTPTKQVFTSDTEAS 548 NP_000536 551 SESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS 600 ||.|||.|.|.|||:|:|||||:.|||||||||||.|||||||||||||| NP_033353 549 SEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQS 598 NP_000536 601 SDSSNGQSHLLPSNHSVIETFISTQMASSSQ 631 || |||.|||||||||||||||||||||||| NP_033353 599 SD-SNGHSHLLPSNHSVIETFISTQMASSSQ 628 #--------------------------------------- #--------------------------------------- >NP_001186948.1| nociceptin receptor [Homo sapiens] >gi|730230|sp|P41146.1|OPRX_HUMAN RecName: Full=Nociceptin receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=Orphanin FQ receptor >gi|13022243|gb|AAK11714.1|AF348323_1 nociceptin receptor [Homo sapiens] >gi|471317|emb|CAA54386.1| ORL1 [Homo sapiens] >gi|1144297|gb|AAA84913.1| orphan opioid receptor [Homo sapiens] >gi|23468341|gb|AAH38433.1| OPRL1 protein [Homo sapiens] >gi|30385528|gb|AAP23195.1| opiate receptor-like 1 [Homo sapiens] >gi|49457075|emb|CAG46858.1| OPRL1 [Homo sapiens] >gi|55960607|emb|CAD11904.2| opiate receptor-like 1 [Homo sapiens] >gi|56204126|emb|CAC17003.2| opiate receptor-like 1 [Homo sapiens] >gi|123993061|gb|ABM84132.1| opiate receptor-like 1 [synthetic construct] >gi|123993063|gb|ABM84133.1| opiate receptor-like 1 [synthetic construct] >gi|157928594|gb|ABW03593.1| opiate receptor-like 1 [synthetic construct] >NP_001239494.1| nociceptin receptor [Mus musculus] >gi|548426|sp|P35377.1|OPRX_MOUSE RecName: Full=Nociceptin receptor; AltName: Full=K3 opiate receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=ORGC; AltName: Full=Orphanin FQ receptor >gi|440880|gb|AAA03730.1| opioid receptor-like protein [Mus musculus] >gi|808874|dbj|BAA06509.1| opioid receptor homologue MOR-C [Mus musculus] >gi|1008982|emb|CAA62922.1| Opioid-like receptor [Mus musculus] >gi|1464791|gb|AAC52669.1| opioid receptor [Mus musculus] >gi|26332699|dbj|BAC30067.1| unnamed protein product [Mus musculus] >gi|26348048|dbj|BAC37672.1| unnamed protein product [Mus musculus] >gi|29747998|gb|AAH50885.1| Opioid receptor-like 1 [Mus musculus] >gi|123232093|emb|CAM20793.1| opioid receptor-like 1 [Mus musculus] >gi|148675513|gb|EDL07460.1| opioid receptor-like 1, isoform CRA_j [Mus musculus] CLUSTAL 2.0.12 multiple sequence alignment NP_001186948.1| MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA NP_001239494.1| MESLFPAPFWEVLYGSHFQGNLSLLNETVPH---HLLLNASHSAFLPLGLKVTIVGLYLA ** ********* **** ******* ******** ***************** NP_001186948.1| VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN NP_001239494.1| VCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN ** ********************************************************* NP_001186948.1| ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV NP_001239494.1| ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV ************************************************************ NP_001186948.1| VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR NP_001239494.1| VGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIR ************************* ******************* *** ********** NP_001186948.1| RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI NP_001239494.1| RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAI ******************************************** ******* ******* NP_001186948.1| LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC NP_001239494.1| LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGC *************************************** * ************* * * NP_001186948.1| KTSETVPRPA NP_001239494.1| KTSETVPRPA ********** >NP_001186948.1| nociceptin receptor [Homo sapiens] >gi|730230|sp|P41146.1|OPRX_HUMAN RecName: Full=Nociceptin receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=Orphanin FQ receptor >gi|13022243|gb|AAK11714.1|AF348323_1 nociceptin receptor [Homo sapiens] >gi|471317|emb|CAA54386.1| ORL1 [Homo sapiens] >gi|1144297|gb|AAA84913.1| orphan opioid receptor [Homo sapiens] >gi|23468341|gb|AAH38433.1| OPRL1 protein [Homo sapiens] >gi|30385528|gb|AAP23195.1| opiate receptor-like 1 [Homo sapiens] >gi|49457075|emb|CAG46858.1| OPRL1 [Homo sapiens] >gi|55960607|emb|CAD11904.2| opiate receptor-like 1 [Homo sapiens] >gi|56204126|emb|CAC17003.2| opiate receptor-like 1 [Homo sapiens] >gi|123993061|gb|ABM84132.1| opiate receptor-like 1 [synthetic construct] >gi|123993063|gb|ABM84133.1| opiate receptor-like 1 [synthetic construct] >gi|157928594|gb|ABW03593.1| opiate receptor-like 1 [synthetic construct] >NP_001239494.1| nociceptin receptor [Mus musculus] >gi|548426|sp|P35377.1|OPRX_MOUSE RecName: Full=Nociceptin receptor; AltName: Full=K3 opiate receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=ORGC; AltName: Full=Orphanin FQ receptor >gi|440880|gb|AAA03730.1| opioid receptor-like protein [Mus musculus] >gi|808874|dbj|BAA06509.1| opioid receptor homologue MOR-C [Mus musculus] >gi|1008982|emb|CAA62922.1| Opioid-like receptor [Mus musculus] >gi|1464791|gb|AAC52669.1| opioid receptor [Mus musculus] >gi|26332699|dbj|BAC30067.1| unnamed protein product [Mus musculus] >gi|26348048|dbj|BAC37672.1| unnamed protein product [Mus musculus] >gi|29747998|gb|AAH50885.1| Opioid receptor-like 1 [Mus musculus] >gi|123232093|emb|CAM20793.1| opioid receptor-like 1 [Mus musculus] >gi|148675513|gb|EDL07460.1| opioid receptor-like 1, isoform CRA_j [Mus musculus] ######################################## # Program: needle # Rundate: Tue 27 Mar 2012 10:29:03 # Commandline: needle # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile global.aln # -auto # Align_format: srspair # Report_file: global.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_001186948 # 2: NP_001239494 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 370 # Identity: 347/370 (93.8%) # Similarity: 355/370 (95.9%) # Gaps: 3/370 ( 0.8%) # Score: 1797.0 # # #======================================= NP_001186948 1 MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGL 50 ||.|||||||||:||||.||||||| :..:|.||||||||.||||||| NP_001239494 1 MESLFPAPFWEVLYGSHFQGNLSLL---NETVPHHLLLNASHSAFLPLGL 47 NP_001186948 51 KVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV 100 ||||||||||||:||||||||||||||||||||||||||||||||||||| NP_001239494 48 KVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV 97 NP_001186948 101 LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYV 150 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_001239494 98 LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYV 147 NP_001186948 151 AICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEC 200 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_001239494 148 AICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEC 197 NP_001186948 201 LVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSG 250 |||||.|||||||||||||||||||:|||:|||||||||||||||||||| NP_001239494 198 LVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSG 247 NP_001186948 251 SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI 300 ||||||||||||||||||||||||||||||||||.|||||||.||||||| NP_001239494 248 SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAI 297 NP_001186948 301 LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVR 350 |||||||||||||||||||||||||||||||||||||||.|::||||||| NP_001239494 298 LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVR 347 NP_001186948 351 SIAKDVALACKTSETVPRPA 370 ||||||.|.||||||||||| NP_001239494 348 SIAKDVGLGCKTSETVPRPA 367 #--------------------------------------- #--------------------------------------- >NP_001186948.1| nociceptin receptor [Homo sapiens] >gi|730230|sp|P41146.1|OPRX_HUMAN RecName: Full=Nociceptin receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=Orphanin FQ receptor >gi|13022243|gb|AAK11714.1|AF348323_1 nociceptin receptor [Homo sapiens] >gi|471317|emb|CAA54386.1| ORL1 [Homo sapiens] >gi|1144297|gb|AAA84913.1| orphan opioid receptor [Homo sapiens] >gi|23468341|gb|AAH38433.1| OPRL1 protein [Homo sapiens] >gi|30385528|gb|AAP23195.1| opiate receptor-like 1 [Homo sapiens] >gi|49457075|emb|CAG46858.1| OPRL1 [Homo sapiens] >gi|55960607|emb|CAD11904.2| opiate receptor-like 1 [Homo sapiens] >gi|56204126|emb|CAC17003.2| opiate receptor-like 1 [Homo sapiens] >gi|123993061|gb|ABM84132.1| opiate receptor-like 1 [synthetic construct] >gi|123993063|gb|ABM84133.1| opiate receptor-like 1 [synthetic construct] >gi|157928594|gb|ABW03593.1| opiate receptor-like 1 [synthetic construct] >NP_001239494.1| nociceptin receptor [Mus musculus] >gi|548426|sp|P35377.1|OPRX_MOUSE RecName: Full=Nociceptin receptor; AltName: Full=K3 opiate receptor; AltName: Full=Kappa-type 3 opioid receptor; Short=KOR-3; AltName: Full=ORGC; AltName: Full=Orphanin FQ receptor >gi|440880|gb|AAA03730.1| opioid receptor-like protein [Mus musculus] >gi|808874|dbj|BAA06509.1| opioid receptor homologue MOR-C [Mus musculus] >gi|1008982|emb|CAA62922.1| Opioid-like receptor [Mus musculus] >gi|1464791|gb|AAC52669.1| opioid receptor [Mus musculus] >gi|26332699|dbj|BAC30067.1| unnamed protein product [Mus musculus] >gi|26348048|dbj|BAC37672.1| unnamed protein product [Mus musculus] >gi|29747998|gb|AAH50885.1| Opioid receptor-like 1 [Mus musculus] >gi|123232093|emb|CAM20793.1| opioid receptor-like 1 [Mus musculus] >gi|148675513|gb|EDL07460.1| opioid receptor-like 1, isoform CRA_j [Mus musculus] ######################################## # Program: water # Rundate: Tue 27 Mar 2012 10:29:03 # Commandline: water # [-asequence] mouse.fa # [-bsequence] human.fa # -outfile local.aln # -auto # Align_format: srspair # Report_file: local.aln ######################################## #======================================= # # Aligned_sequences: 2 # 1: NP_001186948 # 2: NP_001239494 # Matrix: EBLOSUM62 # Gap_penalty: 10.0 # Extend_penalty: 0.5 # # Length: 370 # Identity: 347/370 (93.8%) # Similarity: 355/370 (95.9%) # Gaps: 3/370 ( 0.8%) # Score: 1797.0 # # #======================================= NP_001186948 1 MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGL 50 ||.|||||||||:||||.||||||| :..:|.||||||||.||||||| NP_001239494 1 MESLFPAPFWEVLYGSHFQGNLSLL---NETVPHHLLLNASHSAFLPLGL 47 NP_001186948 51 KVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV 100 ||||||||||||:||||||||||||||||||||||||||||||||||||| NP_001239494 48 KVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV 97 NP_001186948 101 LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYV 150 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_001239494 98 LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYV 147 NP_001186948 151 AICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEC 200 |||||||||||||||||||||||||||||||||||||||||||||||||| NP_001239494 148 AICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIEC 197 NP_001186948 201 LVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSG 250 |||||.|||||||||||||||||||:|||:|||||||||||||||||||| NP_001239494 198 LVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSG 247 NP_001186948 251 SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI 300 ||||||||||||||||||||||||||||||||||.|||||||.||||||| NP_001239494 248 SREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAI 297 NP_001186948 301 LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVR 350 |||||||||||||||||||||||||||||||||||||||.|::||||||| NP_001239494 298 LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVR 347 NP_001186948 351 SIAKDVALACKTSETVPRPA 370 ||||||.|.||||||||||| NP_001239494 348 SIAKDVGLGCKTSETVPRPA 367 #--------------------------------------- #---------------------------------------