LOCUS       AB032966                4748 bp    mRNA    linear   PRI 10-MAY-2002
DEFINITION  Homo sapiens mRNA for KIAA1140 protein, partial cds.
ACCESSION   AB032966
VERSION     AB032966.2  GI:20521777
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
            Hominidae; Homo.
REFERENCE   1
  AUTHORS   Hirosawa,M., Nagase,T., Ishikawa,K., Kikuno,R., Nomura,N. and
            Ohara,O.
  TITLE     Characterization of cDNA clones selected by the GeneMark analysis
            from size-fractionated cDNA libraries from human brain
  JOURNAL   DNA Res. 6 (5), 329-336 (1999)
  MEDLINE   20039618
   PUBMED   10574461
REFERENCE   2  (bases 1 to 4748)
  AUTHORS   Ohara,O., Nagase,T. and Kikuno,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-1999) Osamu Ohara, Kazusa DNA Research Institute,
            Laboratory of DNA Technology; 1532-3 Yana, Kisarazu, Chiba
            292-0812, Japan (E-mail:cdnainfo@kazusa.or.jp,
            URL:http://www.kazusa.or.jp/huge/, Tel:+81-438-52-3913,
            Fax:+81-438-52-3914)
COMMENT     On May 9, 2002 this sequence version replaced gi:6329944.
FEATURES             Location/Qualifiers
     source          1..4748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="hk01004s1"
                     /sex="male"
                     /tissue_type="brain"
                     /clone_lib="pBluescriptII SK plus"
                     /dev_stage="adult"
                     /note="This sequence was obtained bysubcloning of the DNA
                     fragments derived from two cDNA clones (1 - 1023 was
                     derived from aj00420 and 1024 - 4748 was derived from
                     hk01004)."
     gene            1..4748
                     /gene="KIAA1140"
     CDS             <267..2525
                     /gene="KIAA1140"
                     /note="Start codon is not identified."
                     /codon_start=1
                     /product="KIAA1140 protein"
                     /protein_id="BAA86454.2"
                     /db_xref="GI:20521778"
                     /translation="SWANCITWRAHTEMPSACTHGPGLMTCPWRTSPCIRCGCCRRLL
                     SSKHASGFLGEHSPGGQRSCRGGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQ
                     VFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGMRELRE
                     VLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQAL
                     RKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAI
                     YDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLREC
                     VKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYS
                     LQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQ
                     EALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLIFTKVKLEQVLK
                     GPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADS
                     GSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEA
                     GFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLM
                     LSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASS
                     PVLPFSIIPREL"
ORIGIN      
        1 ccatgccaaa ataaaagact ccatgccttt gctggagaag aatgagccga agatgagcga
       61 agccaaaaat tatctaagca gtatccttaa ccatgggagg ctctcgggtc tcgctgtgtt
      121 actcaggctg gtctccaact cctgggctca agcgatcctc ctacttcagc ctcccgaagc
      181 gttgggatta caggagtgag gcactgcgcc cagctgattt ttaaagagct attccaaacc
      241 acagtacatg tgtgaggcca tgctgatcct gggcaaactg cattacgtgg agggctcata
      301 ccgagatgcc atcagcatgt acgcacgggc cgggattgat gacatgtcca tggagaacaa
      361 gcccctgtat cagatgcggc tgctgtcgga ggcttttgtc atcaaagcat gcctccggct
      421 tcttggggga acacagtccc ggtggtcaga ggtcctgcag gggaggcctc tctctggaac
      481 gcctacccaa ctccatcgcc tcccgcttcc gcctgacaga gagggaggag gaagtgatca
      541 cctgttttga gagggcctcc tggatcgctc aggtgttcct gcaggaattg gagaagacca
      601 caaataacag cacgtcgagg catctgaaag gctgtcaccc gcttgactat gagctcacct
      661 acttcctgga agctgccctc cagagcgcct atgtgaaaaa cctgaagaag gggaacatcg
      721 tgaagggcat gagagagctc cgggaggtgc tgcggactgt ggagaccaaa gcaactcaga
      781 acttcaaagt gatggcggcc aagcacctgg cgggggtcct gctgcactcc ctgagtgagg
      841 agtgctactg gagccccctg tcccaccctc tgcctgagtt catgggcaag gaggagagtt
      901 ctttcgccac tcaggccctg cggaaacctc acctctatga aggagacaac ctctactgcc
      961 ccaaggacaa catcgaggaa gccctcctgc tcctcctcat cagcgaatcc atggcaactc
     1021 gagatgtggt gctgagccgg gtgccggagc aggaggagga ccggacagtg agcttgcaga
     1081 atgccgcagc catctatgac ctcctgagca tcacgttggg cagaagggga cagtacgtca
     1141 tgctctcgga gtgcctggag cgagccatga agtttgcgtt tggagaattt cacctttggt
     1201 accaggtggc cctctccatg gtggcttgtg ggaagtcagc ctacgctgtg tccctgctgc
     1261 gggagtgtgt gaagttgcgg ccctcggacc ccaccgtgcc cctgatggcc gcgaaggtct
     1321 gcatcgggtc ccttcgctgg ctagaggaag cagagcactt tgccatgatg gtgatcagcc
     1381 tcggagagga agccggggag ttcctcccca agggctacct ggctctgggt ctcacctata
     1441 gcctgcaggc caccgacgcc accctgaagt ccaagcaaga tgaattgcac cggaaggcac
     1501 tgcagacgct ggagagggct cagcagctgg cgcccagtga cccccaggtc atcctctatg
     1561 tctcgctgca gctggccctc gtccgacaga tctccagtgc catggagcag ctgcaggagg
     1621 ccctgaaggt acgcaaggat gatgcccacg ccctccacct gctggcactg ctcttctctg
     1681 cccagaagca ccaccagcat gccctggatg ttgtcaacat ggccatcacc gagcaccctg
     1741 agaacttcaa cctgatcttc accaaggtga agctggagca ggtgctgaaa ggcccagagg
     1801 aagccctcgt gacctgcaga caagtgctga ggctgtggca gaccctgtac agcttctccc
     1861 agctgggagg cctagaaaag gatggcagct tcggtgaggg cctcaccatg aagaagcaga
     1921 gtggcatgca cctgactttg cctgatgccc atgatgcaga ctctggctcc cggcgggctt
     1981 cgtccatcgc cgcctcccgg ctggaggagg ccatgtcaga gctgactatg ccctcttcgg
     2041 tcctgaagca gggccccatg cagctgtgga ccacgctgga acagatctgg ctgcaggctg
     2101 ctgagctgtt catggagcag cagcacctca aggaagcagg tttctgcatc caggaggcgg
     2161 cgggcctctt ccccacttct cactcagtac tctatatgcg gggccggctg gctgaggtga
     2221 agggcaacct ggaggaggcc aagcagctgt acaaggaggc gctcacggtg aacccagatg
     2281 gcgtgcgcat catgcatagc ctgggtctga tgctgagtcg gctgggccac aagagcttgg
     2341 cccagaaggt gcttcgtgat gccgtggaga ggcagagtac gtgccacgag gcgtggcagg
     2401 gcctgggcga ggtgctgcag gcccagggcc agaacgaggc tgccgttgac tgcttcctca
     2461 ccgcccttga gctggaggcc agcagccctg tactgccctt ctccatcatc cccagagagc
     2521 tctgacgacg ctgcagccgc agggagggag gggctggcca gagggagagg cagcagggaa
     2581 cgtgggtcag ggtggggcaa cagtggcatc aggtgcgggg cctcagggaa atacatcttt
     2641 agtgaacgcc tctgcagctg cagccctcgt tctcttggct gggccaagag ggccttcctg
     2701 gatttctttg ttggtgcctt gggaaacagt ctgacttgaa ccctaagtgc ctttggagag
     2761 ttttgtggtg accagacttg ctccccaaga gctgggcagc ggggagcctc acagctgtcc
     2821 ttcaccctca cccatgcctc tggcttgggg tctgggtggg gggttctcac tccccactct
     2881 cagcacagta cagacttctg gatctctctc aggtcttgcc cagggcggtc acaatgtgaa
     2941 gaaactgcgg gcaagtggga agactatgag atttctgggt tcccttctca gacttggagt
     3001 tagtagatga ttcctgcatt gcccctgctt gccctctgag accagctggg ccccaccttg
     3061 ctctttcccc ctgctaccaa gtgcctttgg ggcctctggg gtctgaccag gggtactgag
     3121 caccggccct aacacttcca tctccaccca ccccatctcc ctggcgatgt gctccagccc
     3181 aagcagcctc cgtaggcttt agatcctgtg gttgctagat ccagtccttt ctaataccct
     3241 gagtcaacac attactcctg caggtcttag gctacaatgc aggtcccttg agggccacca
     3301 acatggaggt aggcagtttc taggactgtc cccagtacat ctcaccaccc acagcccttt
     3361 ttttgccttg attcgagcct caccctggcc ttttggcttc ccctgcctga gagagacctg
     3421 aggaggggac agagcccagc ccctctcctg tggctgagca ggcctctgtg tccatgacac
     3481 ctgtcttccg ggcctggggg ctgtgggtgt atgtcctccc tactggcttc cccggcccct
     3541 gctgcatgat gctcttggaa ctcttctcca aggagtcagt cccccaggcc tatcagggga
     3601 tccttttgta tctgcacttt gggttttagt ttcaaagctc catcaggtac agcttgcatt
     3661 tcaggatgtg tggaaagctc gggtgagggc tgccctggtt catcatagct ccaccttcct
     3721 cggaaggagt gggctgttgg agacccccca tccatggcac actagctcag cactgcattt
     3781 cccgagatga ttcccaagac agctggtgcc tcctggcttt cctgtgccag gccaaggggc
     3841 accacagagg accctggatc ctttgcctct tcttggttga aggatctcta tgtatgtgtg
     3901 tatataaata tagtttttta tctatatata taaaatagag atctattttt tttctggaat
     3961 tctgttagaa aagtaaagaa aaagcaaatg ctgttggttt atctcagggt gcccaaagtg
     4021 gttatagtca atttttggta ctaggaaagg cacccaatgc atttcctgac ttttaagcat
     4081 ttccttgttg gaagcagcag agggccaggc caagttgctg acagtgactt tgcaggttga
     4141 ataaagaaac ccttggaggg gaagcaggct tgtctgaagc agcatgtata ttcactgggc
     4201 atgtagctcc cacaccagcc ttgagccagg ccctggacag gaggggctgt tgcaggatga
     4261 gggaggccag agaaggcatc gaagccaaga cctgggccca gctggggagg gatgtgggaa
     4321 aggaaggatg ggagggagga ccctctggga aaatgtggat ttgagctggt gagagtgttg
     4381 ctaaggctgg gctaaagcct ggagagggta ggaggaggca agaggggtcc aggcagggct
     4441 gatcctggcc tctgacctgt ccagggcgac ccctgaagcc cctgctgcct ctgggcattg
     4501 ctgggagagg ccaaggcagg actcacgtct gaacagagat cccctcgggc attgctgatg
     4561 ggccaccttc agctgcaggg aagaagccta ggagaggagg catgggaggg acctgggcct
     4621 tgttcagatt ggccacctct gctgagaagt ccataccagt acacccctaa taagttatgc
     4681 cacataccaa cgtactgtgg atattataac ctgcattaaa acaactctaa agaacgctgc
     4741 tcatttac
//

LOCUS       NM_000075               1474 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA.
ACCESSION   NM_000075 NM_032913
VERSION     NM_000075.2  GI:16936531
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Wallace,M. and Ball,K.L.
  TITLE     Docking-dependent regulation of the Rb tumor suppressor protein by
            Cdk4
  JOURNAL   Mol. Cell. Biol. 24 (12), 5606-5619 (2004)
   PUBMED   15169919
  REMARK    GeneRIF: A novel Cdk4 docking motif has been defined within a
            stretch of 19 amino acids from the C-terminal domain of the Rb
            protein that are essential for Cdk4 binding.
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Liu,E., Li,X., Yan,F., Zhao,Q. and Wu,X.
  TITLE     Cyclin-dependent kinases phosphorylate human Cdt1 and induce its
            degradation
  JOURNAL   J. Biol. Chem. 279 (17), 17283-17288 (2004)
   PUBMED   15004027
  REMARK    GeneRIF: Cdk2 and Cdk4 phosphorylate human Cdt1 and induce its
            degradation
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Kahl,C.R. and Means,A.R.
  TITLE     Regulation of cyclin D1/Cdk4 complexes by
            calcium/calmodulin-dependent protein kinase I
  JOURNAL   J. Biol. Chem. 279 (15), 15411-15419 (2004)
   PUBMED   14754892
  REMARK    GeneRIF: cyclin D1/Cdk4 complexes are regulated by
            calcium/calmodulin-dependent protein kinase I
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Zhao,Q., Boschelli,F., Caplan,A.J. and Arndt,K.T.
  TITLE     Identification of a conserved sequence motif that promotes Cdc37
            and cyclin D1 binding to Cdk4
  JOURNAL   J. Biol. Chem. 279 (13), 12560-12564 (2004)
   PUBMED   14701845
  REMARK    GeneRIF: CDK4 binding to cyclin D1 is stimulated by Cdc37
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Miliani de Marval,P.L., Macias,E., Conti,C.J. and
            Rodriguez-Puebla,M.L.
  TITLE     Enhanced malignant tumorigenesis in Cdk4 transgenic mice
  JOURNAL   Oncogene 23 (10), 1863-1873 (2004)
   PUBMED   14647432
  REMARK    GeneRIF: susceptibility to skin tumor formation by forced
            expression of CDK4
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Klausen,P., Bjerregaard,M.D., Borregaard,N. and Cowland,J.B.
  TITLE     End-stage differentiation of neutrophil granulocytes in vivo is
            accompanied by up-regulation of p27kip1 and down-regulation of
            CDK2, CDK4, and CDK6
  JOURNAL   J. Leukoc. Biol. 75 (3), 569-578 (2004)
   PUBMED   14694185
  REMARK    GeneRIF: cyclin-dependent kinase (CDK)2, -4, and -6 were
            down-regulated from the myelocytes/metamyelocytes stages and onward
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Mishra,R. and Das,B.R.
  TITLE     Early overexpression of Cdk4 and possible role of KRF and c-myc in
            chewing tobacco mediated oral cancer development
  JOURNAL   Mol. Biol. Rep. 30 (4), 207-213 (2003)
   PUBMED   14672406
  REMARK    GeneRIF: Data suggest that cyclin dependent kinase 4 is involved in
            the development of tobacco-mediated oral carcinogenesis, and that
            c-myc expression is absent in normal and high in later stages of
            oral cancer development.
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Kim,D.M., Yang,K. and Yang,B.S.
  TITLE     Biochemical characterizations reveal different properties between
            CDK4/cyclin D1 and CDK2/cyclin A
  JOURNAL   Exp. Mol. Med. 35 (5), 421-430 (2003)
   PUBMED   14646596
  REMARK    GeneRIF: significant difference in their biochemical properties
            between CDK4/cyclin D1 and CDK2/cyclin A affecting regulation of
            cellular RB function
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Mori,N., Yang,R., Kawamata,N., Miller,C.W., Mizoguchi,H. and
            Koeffler,H.P.
  TITLE     Absence of R24C mutation of the CDK4 gene in leukemias and solid
            tumors
  JOURNAL   Int. J. Hematol. 77 (3), 259-262 (2003)
   PUBMED   12731669
  REMARK    GeneRIF: DNA mutation analysis of the CDK4 gene in many types of
            neoplasms reveal it is very rare. Random mutagenisis the CDK4 gene
            showed that most of the mutations that disrupted interactions with
            p16(INK4) also knocked out the activity of CDK4.
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Masaki,T., Shiratori,Y., Rengifo,W., Igarashi,K., Yamagata,M.,
            Kurokohchi,K., Uchida,N., Miyauchi,Y., Yoshiji,H., Watanabe,S.,
            Omata,M. and Kuriyama,S.
  TITLE     Cyclins and cyclin-dependent kinases: comparative study of
            hepatocellular carcinoma versus cirrhosis
  JOURNAL   Hepatology 37 (3), 534-543 (2003)
   PUBMED   12601350
  REMARK    GeneRIF: increases of cyclin D1, cyclin-dependent kinase 4, cyclin
            E, cyclin A, and Wee1 play an important role in the development of
            hepatocellular carcinoma from cirrhosis
REFERENCE   11 (bases 1 to 1474)
  AUTHORS   Gump,J., Stokoe,D. and McCormick,F.
  TITLE     Phosphorylation of p16INK4A correlates with Cdk4 association
  JOURNAL   J. Biol. Chem. 278 (9), 6619-6622 (2003)
   PUBMED   12529334
  REMARK    GeneRIF: Cdk4 binds to p16INK4A and causes its phosphorylation
REFERENCE   12 (bases 1 to 1474)
  AUTHORS   Ramirez,R.D., Herbert,B.S., Vaughan,M.B., Zou,Y., Gandia,K.,
            Morales,C.P., Wright,W.E. and Shay,J.W.
  TITLE     Bypass of telomere-dependent replicative senescence (M1) upon
            overexpression of Cdk4 in normal human epithelial cells
  JOURNAL   Oncogene 22 (3), 433-444 (2003)
   PUBMED   12545164
  REMARK    GeneRIF: Cdk4-overexpressing cells divide in an apparently normal
            regulated fashion, are able to respond to changes in calcium
            levels, and fully differentiate . These results suggest that the
            differentiation pathways in Cdk4-overexpressing cells remain intact
REFERENCE   13 (bases 1 to 1474)
  AUTHORS   Detjen,K.M., Murphy,D., Welzel,M., Farwig,K., Wiedenmann,B. and
            Rosewicz,S.
  TITLE     Downregulation of p21(waf/cip-1) mediates apoptosis of human
            hepatocellular carcinoma cells in response to interferon-gamma
  JOURNAL   Exp. Cell Res. 282 (2), 78-89 (2003)
   PUBMED   12531694
  REMARK    GeneRIF: Interferon gamma reduces the activity of Cdk4 and Cdk2,
            inhibiting he G1 cell cycle in human hepatocellular carcinoma
            cells.
REFERENCE   14 (bases 1 to 1474)
  AUTHORS   Katayama,K., Dobashi,Y., Kitagawa,M., Kawai,M., Kadoya,Y. and
            Kameya,T.
  TITLE     Cdk4/cyclin D1 kinase, a universal and critical regulator of
            apoptosis
  JOURNAL   Anticancer Res. 23 (1A), 235-243 (2003)
   PUBMED   12680219
  REMARK    GeneRIF: Cells overexpressing cdk4 or cyclin D1 exhibited nuclear
            features characteristic of apoptosis.
REFERENCE   15 (bases 1 to 1474)
  AUTHORS   Nikitakis,N.G., Drachenberg,C.B. and Papadimitriou,J.C.
  TITLE     MDM2 and CDK4 expression in carcinosarcoma of the esophagus:
            comparison with squamous cell carcinoma and review of the
            literature
  JOURNAL   Exp. Mol. Pathol. 73 (3), 198-208 (2002)
   PUBMED   12565795
  REMARK    GeneRIF: Data provide evidence of a role for MDM2 and CDK4 in the
            pathogenesis of carcinosarcoma.
REFERENCE   16 (bases 1 to 1474)
  AUTHORS   Lazarov,M., Kubo,Y., Cai,T., Dajee,M., Tarutani,M., Lin,Q.,
            Fang,M., Tao,S., Green,C.L. and Khavari,P.A.
  TITLE     CDK4 coexpression with Ras generates malignant human epidermal
            tumorigenesis
  JOURNAL   Nat. Med. 8 (10), 1105-1114 (2002)
   PUBMED   12357246
  REMARK    GeneRIF: data identify a new role for oncogenic Ras in CDK4
            regulation and highlight the functional importance of CDK4
            suppression in preventing uncontrolled growth
REFERENCE   17 (bases 1 to 1474)
  AUTHORS   Rheinwald,J.G., Hahn,W.C., Ramsey,M.R., Wu,J.Y., Guo,Z., Tsao,H.,
            De Luca,M., Catricala,C. and O'Toole,K.M.
  TITLE     A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence
            mechanism that limits replicative potential independent of telomere
            status
  JOURNAL   Mol. Cell. Biol. 22 (14), 5157-5172 (2002)
   PUBMED   12077343
  REMARK    GeneRIF: Keratinocytes engineered to express cdk4(R24C) and hTERT
            but not p53DD did not exhibit an extended life span.
REFERENCE   18 (bases 1 to 1474)
  AUTHORS   Morris,M., Hepburn,P. and Wynford-Thomas,D.
  TITLE     Sequential extension of proliferative lifespan in human fibroblasts
            induced by over-expression of CDK4 or 6 and loss of p53 function
  JOURNAL   Oncogene 21 (27), 4277-4288 (2002)
   PUBMED   12082615
  REMARK    GeneRIF: Sequential extension of proliferative lifespan in human
            fibroblasts is induced by over-expression of CDK4 or 6 and loss of
            p53 function.
REFERENCE   19 (bases 1 to 1474)
  AUTHORS   Korz,C., Pscherer,A., Benner,A., Mertens,D., Schaffner,C.,
            Leupolt,E., Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Evidence for distinct pathomechanisms in B-cell chronic lymphocytic
            leukemia and mantle cell lymphoma by quantitative expression
            analysis of cell cycle and apoptosis-associated genes
  JOURNAL   Blood 99 (12), 4554-4561 (2002)
   PUBMED   12036888
REFERENCE   20 (bases 1 to 1474)
  AUTHORS   Kim,A.L., Athar,M., Bickers,D.R. and Gautier,J.
  TITLE     Ultraviolet-B-induced G1 arrest is mediated by downregulation of
            cyclin-dependent kinase 4 in transformed keratinocytes lacking
            functional p53
  JOURNAL   J. Invest. Dermatol. 118 (5), 818-824 (2002)
   PUBMED   11982759
  REMARK    GeneRIF: ultraviolet-B-induced cell cycle arrest in A431 cells is
            mediated by cyclin-dependent kinase 4 downregulation
REFERENCE   21 (bases 1 to 1474)
  AUTHORS   Haller,K., Wu,Y., Derow,E., Schmitt,I., Jeang,K.T. and Grassmann,R.
  TITLE     Physical interaction of human T-cell leukemia virus type 1 Tax with
            cyclin-dependent kinase 4 stimulates the phosphorylation of
            retinoblastoma protein
  JOURNAL   Mol. Cell. Biol. 22 (10), 3327-3338 (2002)
   PUBMED   11971966
  REMARK    GeneRIF: Results show that Tax directly interacts with CDK4.  The
            Tax/CDK complex represents an active holoenzyme which capably
            phosphorylates the Rb protein in vitro and is resistant to
            repression by the inhibitor p21(CIP).
REFERENCE   22 (bases 1 to 1474)
  AUTHORS   Leng,X., Noble,M., Adams,P.D., Qin,J. and Harper,J.W.
  TITLE     Reversal of growth suppression by p107 via direct phosphorylation
            by cyclin D1/cyclin-dependent kinase 4
  JOURNAL   Mol. Cell. Biol. 22 (7), 2242-2254 (2002)
   PUBMED   11884610
  REMARK    GeneRIF: Reversal of growth suppression by p107 via direct
            phosphorylation by cyclin D1/cyclin-dependent kinase 4
REFERENCE   23 (bases 1 to 1474)
  AUTHORS   Goldstein,A.M., Chidambaram,A., Halpern,A., Holly,E.A., Guerry
            IV,D., Sagebiel,R., Elder,D.E. and Tucker,M.A.
  TITLE     Rarity of CDK4 germline mutations in familial melanoma
  JOURNAL   Melanoma Res. 12 (1), 51-55 (2002)
   PUBMED   11828258
  REMARK    GeneRIF: Rarity of CDK4 germline mutations in familial melanoma.
REFERENCE   24 (bases 1 to 1474)
  AUTHORS   Nekhai,S., Shukla,R.R., Fernandez,A., Kumar,A. and Lamb,N.J.
  TITLE     Cell cycle-dependent stimulation of the HIV-1 promoter by
            Tat-associated CAK activator
  JOURNAL   Virology 266 (2), 246-256 (2000)
   PUBMED   10639311
REFERENCE   25 (bases 1 to 1474)
  AUTHORS   Harbour,J.W., Luo,R.X., Dei Santi,A., Postigo,A.A. and Dean,D.C.
  TITLE     Cdk phosphorylation triggers sequential intramolecular interactions
            that progressively block Rb functions as cells move through G1
  JOURNAL   Cell 98 (6), 859-869 (1999)
   PUBMED   10499802
REFERENCE   26 (bases 1 to 1474)
  AUTHORS   Zuo,L., Weger,J., Yang,Q., Goldstein,A.M., Tucker,M.A.,
            Walker,G.J., Hayward,N. and Dracopoli,N.C.
  TITLE     Germline mutations in the p16INK4a binding domain of CDK4 in
            familial melanoma
  JOURNAL   Nat. Genet. 12 (1), 97-99 (1996)
   PUBMED   8528263
REFERENCE   27 (bases 1 to 1474)
  AUTHORS   Wolfel,T., Hauer,M., Schneider,J., Serrano,M., Wolfel,C.,
            Klehmann-Hieb,E., De Plaen,E., Hankeln,T., Meyer zum
            Buschenfelde,K.H. and Beach,D.
  TITLE     A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T
            lymphocytes in a human melanoma
  JOURNAL   Science 269 (5228), 1281-1284 (1995)
   PUBMED   7652577
REFERENCE   28 (bases 1 to 1474)
  AUTHORS   Mitchell,E.L., White,G.R., Santibanez-Koref,M.F., Varley,J.M. and
            Heighway,J.
  TITLE     Mapping of gene loci in the Q13-Q15 region of chromosome 12
  JOURNAL   Chromosome Res. 3 (4), 261-262 (1995)
   PUBMED   7606365
REFERENCE   29 (bases 1 to 1474)
  AUTHORS   Demetrick,D.J., Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase
            genes
  JOURNAL   Cytogenet. Cell Genet. 66 (1), 72-74 (1994)
   PUBMED   8275715
REFERENCE   30 (bases 1 to 1474)
  AUTHORS   Serrano,M., Hannon,G.J. and Beach,D.
  TITLE     A new regulatory motif in cell-cycle control causing specific
            inhibition of cyclin D/CDK4
  JOURNAL   Nature 366 (6456), 704-707 (1993)
   PUBMED   8259215
REFERENCE   31 (bases 1 to 1474)
  AUTHORS   Kato,J., Matsushime,H., Hiebert,S.W., Ewen,M.E. and Sherr,C.J.
  TITLE     Direct binding of cyclin D to the retinoblastoma gene product (pRb)
            and pRb phosphorylation by the cyclin D-dependent kinase CDK4
  JOURNAL   Genes Dev. 7 (3), 331-342 (1993)
   PUBMED   8449399
REFERENCE   32 (bases 1 to 1474)
  AUTHORS   Hanks,S.K.
  TITLE     Homology probing: identification of cDNA clones encoding members of
            the protein-serine kinase family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (2), 388-392 (1987)
   PUBMED   2948189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M14505.1 and BC003644.2.
            On or before Nov 4, 2002 this sequence version replaced
            gi:14249693, gi:4502734.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family. This protein is highly similar to
            the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a
            catalytic subunit of the protein kinase complex that is important
            for cell cycle G1 phase progression. The activity of this kinase is
            restricted to the G1-S phase, which is controlled by the regulatory
            subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase
            was shown to be responsible for the phosphorylation of
            retinoblastoma gene product (Rb). Mutations in this gene as well as
            in its related proteins including D-type cyclins, p16(INK4a) and Rb
            were all found to be associated with tumorigenesis of a variety of
            cancers. Multiple polyadenylation sites of this gene have been
            reported.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14"
     gene            1..1474
                     /gene="CDK4"
                     /note="synonyms: CMM3, PSK-J3, MGC14458"
                     /db_xref="GeneID:1019"
                     /db_xref="MIM:123829"
     CDS             228..1139
                     /gene="CDK4"
                     /EC_number="2.7.1.-"
                     /note="cell division kinase 4; melanoma cutaneous
                     malignant, 3;
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: protein kinase activity [goid 0004672]
                     [evidence IEA];
                     go_function: cyclin-dependent protein kinase activity
                     [goid 0004693] [evidence TAS] [pmid 10499802];
                     go_process: cytokinesis [goid 0000910] [evidence IEA];
                     go_process: regulation of cell cycle [goid 0000074]
                     [evidence TAS] [pmid 7652577];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence IEA];
                     go_process: G1/S transition of mitotic cell cycle [goid
                     0000082] [evidence TAS] [pmid 10499802]"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4"
                     /protein_id="NP_000066.1"
                     /db_xref="GI:4502735"
                     /db_xref="GeneID:1019"
                     /db_xref="MIM:123829"
                     /translation="MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGG
                     GGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT
                     YLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG
                     LARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS
                     EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEML
                     TFNPHKRISAFRALQHSYLHKDEGNPE"
     misc_feature    492..841
                     /gene="CDK4"
                     /note="Region: the region absent in variant 2"
     polyA_site      1413
                     /gene="CDK4"
                     /evidence=experimental
     polyA_site      1420
                     /gene="CDK4"
                     /evidence=experimental
     polyA_site      1423
                     /gene="CDK4"
                     /evidence=experimental
     polyA_site      1428
                     /gene="CDK4"
                     /evidence=experimental
     polyA_site      1442
                     /gene="CDK4"
ORIGIN      
        1 agccctccca gtttccgcgc gcctctttgg cagctggtca catggtgagg gtgggggtga
       61 gggggcctct ctagcttgcg gcctgtgtct atggtcgggc cctctgcgtc cagctgctcc
      121 ggaccgagct cgggtgtatg gggccgtagg aaccggctcc ggggccccga taacgggccg
      181 cccccacagc accccgggct ggcgtgaggg tctcccttga tctgagaatg gctacctctc
      241 gatatgagcc agtggctgaa attggtgtcg gtgcctatgg gacagtgtac aaggcccgtg
      301 atccccacag tggccacttt gtggccctca agagtgtgag agtccccaat ggaggaggag
      361 gtggaggagg ccttcccatc agcacagttc gtgaggtggc tttactgagg cgactggagg
      421 cttttgagca tcccaatgtt gtccggctga tggacgtctg tgccacatcc cgaactgacc
      481 gggagatcaa ggtaaccctg gtgtttgagc atgtagacca ggacctaagg acatatctgg
      541 acaaggcacc cccaccaggc ttgccagccg aaacgatcaa ggatctgatg cgccagtttc
      601 taagaggcct agatttcctt catgccaatt gcatcgttca ccgagatctg aagccagaga
      661 acattctggt gacaagtggt ggaacagtca agctggctga ctttggcctg gccagaatct
      721 acagctacca gatggcactt acacccgtgg ttgttacact ctggtaccga gctcccgaag
      781 ttcttctgca gtccacatat gcaacacctg tggacatgtg gagtgttggc tgtatctttg
      841 cagagatgtt tcgtcgaaag cctctcttct gtggaaactc tgaagccgac cagttgggca
      901 aaatctttga cctgattggg ctgcctccag aggatgactg gcctcgagat gtatccctgc
      961 cccgtggagc ctttcccccc agagggcccc gcccagtgca gtcggtggta cctgagatgg
     1021 aggagtcggg agcacagctg ctgctggaaa tgctgacttt taacccacac aagcgaatct
     1081 ctgcctttcg agctctgcag cactcttatc tacataagga tgaaggtaat ccggagtgag
     1141 caatggagtg gctgccatgg aaggaagaaa agctgccatt tcccttctgg acactgagag
     1201 ggcaatcttt gcctttatct ctgaggctat ggagggtcct cctccatctt tctacagaga
     1261 ttactttgct gccttaatga cattcccctc ccacctctcc ttttgaggct tctccttctc
     1321 cttcccattt ctctacacta aggggtatgt tccctcttgt ccctttccct acctttatat
     1381 ttggggtcct tttttataca ggaaaaacaa aacaaagaaa taatggtctt tttttttttt
     1441 ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//

LOCUS       NM_000104               5128 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens cytochrome P450, family 1, subfamily B, polypeptide 1
            (CYP1B1), mRNA.
ACCESSION   NM_000104
VERSION     NM_000104.2  GI:13325059
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5128)
  AUTHORS   Rodriguez-Melendez,R., Griffin,J.B. and Zempleni,J.
  TITLE     Biotin supplementation increases expression of the cytochrome P450
            1B1 gene in Jurkat cells, increasing the occurrence of
            single-stranded DNA breaks
  JOURNAL   J. Nutr. 134 (9), 2222-2228 (2004)
   PUBMED   15333708
  REMARK    GeneRIF: Transcription factors with an affinity for Sp1 sites
            mediate transcriptional activation of the CYP1B1 gene in
            biotin-supplemented T cells, increasing the occurrence of
            single-stranded DNA breaks.
REFERENCE   2  (bases 1 to 5128)
  AUTHORS   McGrath,M., Hankinson,S.E., Arbeitman,L., Colditz,G.A., Hunter,D.J.
            and De Vivo,I.
  TITLE     Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms
            and endometrial cancer susceptibility
  JOURNAL   Carcinogenesis 25 (4), 559-565 (2004)
   PUBMED   14656940
  REMARK    GeneRIF: Carriers of the CYP1B1 Ser allele had a statistically
            significant decreased risk of endometrial cancer.
REFERENCE   3  (bases 1 to 5128)
  AUTHORS   Curry,S.M., Daou,A.G., Hermanns,P., Molinari,A., Lewis,R.A. and
            Bejjani,B.A.
  TITLE     Cytochrome P4501B1 mutations cause only part of primary congenital
            glaucoma in Ecuador
  JOURNAL   Ophthalmic Genet. 25 (1), 3-9 (2004)
   PUBMED   15255109
  REMARK    GeneRIF: Mutations in CYPIBI are not a major cause of PCG (primary
            congenital glaucoma) in this population and that at least one
            additional locus for this condition is responsible for most cases.
REFERENCE   4  (bases 1 to 5128)
  AUTHORS   Han,W., Kang,D., Park,I.A., Kim,S.W., Bae,J.Y., Chung,K.W. and
            Noh,D.Y.
  TITLE     Associations between breast cancer susceptibility gene
            polymorphisms and clinicopathological features
  JOURNAL   Clin. Cancer Res. 10 (1 Pt 1), 124-130 (2004)
   PUBMED   14734460
  REMARK    GeneRIF: Single Nucleotide Polymorphisms of CYP1B1 is associated
            with breast cancer
REFERENCE   5  (bases 1 to 5128)
  AUTHORS   Sena,D.F., Finzi,S., Rodgers,K., Del Bono,E., Haines,J.L. and
            Wiggs,J.L.
  TITLE     Founder mutations of CYP1B1 gene in patients with congenital
            glaucoma from the United States and Brazil
  JOURNAL   J. Med. Genet. 41 (1), E6 (2004)
   PUBMED   14729846
  REMARK    GeneRIF: Four founder mutations were identified in congenital
            glaucoma patients in two ethnically heterogeneous populations.
REFERENCE   6  (bases 1 to 5128)
  AUTHORS   Reddy,A.B., Panicker,S.G., Mandal,A.K., Hasnain,S.E. and
            Balasubramanian,D.
  TITLE     Identification of R368H as a predominant CYP1B1 allele causing
            primary congenital glaucoma in Indian patients
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 44 (10), 4200-4203 (2003)
   PUBMED   14507861
  REMARK    GeneRIF: Identification of R368H as a predominant CYP1B1 allele
            causing primary congenital glaucoma in Indian patients.
REFERENCE   7  (bases 1 to 5128)
  AUTHORS   Rylander-Rudqvist,T., Wedren,S., Granath,F., Humphreys,K.,
            Ahlberg,S., Weiderpass,E., Oscarson,M., Ingelman-Sundberg,M. and
            Persson,I.
  TITLE     Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast
            cancer risk
  JOURNAL   Carcinogenesis 24 (9), 1533-1539 (2003)
   PUBMED   12844487
  REMARK    GeneRIF: the studied CYP1B1 gene polymorphisms do not influence
            breast cancer risk overall but may modify the risk after long-term
            menopausal hormone use.
REFERENCE   8  (bases 1 to 5128)
  AUTHORS   Sasaki,M., Tanaka,Y., Kaneuchi,M., Sakuragi,N. and Dahiya,R.
  TITLE     CYP1B1 gene polymorphisms have higher risk for endometrial cancer,
            and positive correlations with estrogen receptor alpha and estrogen
            receptor beta expressions
  JOURNAL   Cancer Res. 63 (14), 3913-3918 (2003)
   PUBMED   12873984
  REMARK    GeneRIF: Rare polymorphisms at codons 119 and 432 of CYP1B1 gene
            have higher risk for endometrial cancer, and positive correlations
            with ERalpha and ERbeta expressions in endometrial cancer.
REFERENCE   9  (bases 1 to 5128)
  AUTHORS   Kang,M.K., Kameta,A., Shin,K.H., Baluda,M.A., Kim,H.R. and
            Park,N.H.
  TITLE     Senescence-associated genes in normal human oral keratinocytes
  JOURNAL   Exp. Cell Res. 287 (2), 272-281 (2003)
   PUBMED   12837283
  REMARK    GeneRIF: CYP1B1 is a senescence-associated gene in normal human
            oral keratinocytes.
REFERENCE   10 (bases 1 to 5128)
  AUTHORS   Mammen,J.S., Pittman,G.S., Li,Y., Abou-Zahr,F., Bejjani,B.A.,
            Bell,D.A., Strickland,P.T. and Sutter,T.R.
  TITLE     Single amino acid mutations, but not common polymorphisms, decrease
            the activity of CYP1B1 against
            (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol
  JOURNAL   Carcinogenesis 24 (7), 1247-1255 (2003)
   PUBMED   12807732
  REMARK    GeneRIF: Single amino acid mutations, but not common polymorphisms,
            decrease the activity of CYP1B1 against
            (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol.
REFERENCE   11 (bases 1 to 5128)
  AUTHORS   Sasaki,M., Kaneuchi,M., Fujimoto,S., Tanaka,Y. and Dahiya,R.
  TITLE     CYP1B1 gene in endometrial cancer
  JOURNAL   Mol. Cell. Endocrinol. 202 (1-2), 171-176 (2003)
   PUBMED   12770747
  REMARK    GeneRIF: polymorphism and risk of endometrial cancer
REFERENCE   12 (bases 1 to 5128)
  AUTHORS   Kadlubar,F.F., Berkowitz,G.S., Delongchamp,R.R., Wang,C.,
            Green,B.L., Tang,G., Lamba,J., Schuetz,E. and Wolff,M.S.
  TITLE     The CYP3A4*1B variant is related to the onset of puberty, a known
            risk factor for the development of breast cancer
  JOURNAL   Cancer Epidemiol. Biomarkers Prev. 12 (4), 327-331 (2003)
   PUBMED   12692107
  REMARK    GeneRIF: High-activity CYP1A2 and CYP1B1 alleles, whose gene
            products metabolize estradiol, were not associated with pubertal
            stage.
REFERENCE   13 (bases 1 to 5128)
  AUTHORS   Soley,G.C., Bosse,K.A., Flikier,D., Flikier,P., Azofeifa,J.,
            Mardin,C.Y., Reis,A., Michels-Rautenstrauss,K.G. and
            Rautenstrauss,B.W.
  TITLE     Primary congenital glaucoma: a novel single-nucleotide deletion and
            varying phenotypic expression for the 1,546-1,555dup mutation in
            the GLC3A (CYP1B1) gene in 2 families of different ethnic origin
  JOURNAL   J Glaucoma 12 (1), 27-30 (2003)
   PUBMED   12567107
  REMARK    GeneRIF: The phenotypic expression of 3 patients confirm the
            crucial role of CYP1B1 mutations for congenital glaucoma.
REFERENCE   14 (bases 1 to 5128)
  AUTHORS   Sitorus,R., Ardjo,S.M., Lorenz,B. and Preising,M.
  TITLE     CYP1B1 gene analysis in primary congenital glaucoma in Indonesian
            and European patients
  JOURNAL   J. Med. Genet. 40 (1), E9 (2003)
   PUBMED   12525557
  REMARK    GeneRIF: CYP1B1 gene is a major gene associated with primary
            congenital glaucoma (GLC3A).
REFERENCE   15 (bases 1 to 5128)
  AUTHORS   Chang,T.K., Chen,J., Pillay,V., Ho,J.Y. and Bandiera,S.M.
  TITLE     Real-time polymerase chain reaction analysis of CYP1B1 gene
            expression in human liver
  JOURNAL   Toxicol. Sci. 71 (1), 11-19 (2003)
   PUBMED   12520071
  REMARK    GeneRIF: CYP1B1 mRNA is expressed in human liver and the levels are
            increased in smokers, but the protein is undetectable.
REFERENCE   16 (bases 1 to 5128)
  AUTHORS   Tanaka,Y., Sasaki,M., Kaneuchi,M., Shiina,H., Igawa,M. and
            Dahiya,R.
  TITLE     Polymorphisms of the CYP1B1 gene have higher risk for prostate
            cancer
  JOURNAL   Biochem. Biophys. Res. Commun. 296 (4), 820-826 (2002)
   PUBMED   12200121
  REMARK    GeneRIF: CYP1B1 polymorphism in prostate neoplasms
REFERENCE   17 (bases 1 to 5128)
  AUTHORS   Wang,H.W., Chen,T.L., Yang,P.C., Ma,Y.C., Yu,C.C. and Ueng,T.H.
  TITLE     Induction of cytochromes P450 1A1 and 1B1 in human lung
            adenocarcinoma CL5 cells by frying-meat emission particulate
  JOURNAL   Food Chem Toxicol 40 (5), 653-661 (2002)
   PUBMED   11955671
  REMARK    GeneRIF: airborne particulates generated during the frying of beef,
            fish and pork can induce carcinogen-metabolizing CYP1B1 in the
            human lung-derived cell line
REFERENCE   18 (bases 1 to 5128)
  AUTHORS   Vincent,A.L., Billingsley,G., Buys,Y., Levin,A.V., Priston,M.,
            Trope,G., Williams-Lyn,D. and Heon,E.
  TITLE     Digenic inheritance of early-onset glaucoma: CYP1B1, a potential
            modifier gene
  JOURNAL   Am. J. Hum. Genet. 70 (2), 448-460 (2002)
   PUBMED   11774072
  REMARK    GeneRIF: digenic inheritance of early-onset glaucoma: CYP1B1, a
            potential modifier gene
REFERENCE   19 (bases 1 to 5128)
  AUTHORS   Lai,J., Vesprini,D., Chu,W., Jernstrom,H. and Narod,S.A.
  TITLE     CYP gene polymorphisms and early menarche
  JOURNAL   Mol. Genet. Metab. 74 (4), 449-457 (2001)
   PUBMED   11749050
  REMARK    GeneRIF: Investigators examining possible associations between
            early menarche and mutations in genes of estrogen metabolism found
            no such association for this gene.
REFERENCE   20 (bases 1 to 5128)
  AUTHORS   Michels-Rautenstrauss,K.G., Mardin,C.Y., Zenker,M., Jordan,N.,
            Gusek-Schneider,G.C. and Rautenstrauss,B.W.
  TITLE     Primary congenital glaucoma: three case reports on novel mutations
            and combinations of mutations in the GLC3A (CYP1B1) gene
  JOURNAL   J Glaucoma 10 (4), 354-357 (2001)
   PUBMED   11558822
  REMARK    GeneRIF: CYP1B1 mutations for congenital glaucoma
REFERENCE   21 (bases 1 to 5128)
  AUTHORS   Vincent,A., Billingsley,G., Priston,M., Williams-Lyn,D.,
            Sutherland,J., Glaser,T., Oliver,E., Walter,M.A., Heathcote,G.,
            Levin,A. and Heon,E.
  TITLE     Phenotypic heterogeneity of CYP1B1: mutations in a patient with
            Peters' anomaly
  JOURNAL   J. Med. Genet. 38 (5), 324-326 (2001)
   PUBMED   11403040
  REMARK    GeneRIF: mutations in a patient with Peters' anomaly
REFERENCE   22 (bases 1 to 5128)
  AUTHORS   Lewis,D.F., Lake,B.G., George,S.G., Dickins,M., Eddershaw,P.J.,
            Tarbit,M.H., Beresford,A.P., Goldfarb,P.S. and Guengerich,F.P.
  TITLE     Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6
            and CYP1B1 based on sequence homology with CYP102
  JOURNAL   Toxicology 139 (1-2), 53-79 (1999)
   PUBMED   10614688
REFERENCE   23 (bases 1 to 5128)
  AUTHORS   Smith,G., Stubbins,M.J., Harries,L.W. and Wolf,C.R.
  TITLE     Molecular genetics of the human cytochrome P450 monooxygenase
            superfamily
  JOURNAL   Xenobiotica 28 (12), 1129-1165 (1998)
   PUBMED   9890157
REFERENCE   24 (bases 1 to 5128)
  AUTHORS   Tang,Y.M., Wo,Y.Y., Stewart,J., Hawkins,A.L., Griffin,C.A.,
            Sutter,T.R. and Greenlee,W.F.
  TITLE     Isolation and characterization of the human cytochrome P450 CYP1B1
            gene
  JOURNAL   J. Biol. Chem. 271 (45), 28324-28330 (1996)
   PUBMED   8910454
REFERENCE   25 (bases 1 to 5128)
  AUTHORS   Sutter,T.R., Tang,Y.M., Hayes,C.L., Wo,Y.Y., Jabs,E.W., Li,X.,
            Yin,H., Cody,C.W. and Greenlee,W.F.
  TITLE     Complete cDNA sequence of a human dioxin-inducible mRNA identifies
            a new gene subfamily of cytochrome P450 that maps to chromosome 2
  JOURNAL   J. Biol. Chem. 269 (18), 13092-13099 (1994)
   PUBMED   8175734
REFERENCE   26 (bases 1 to 5128)
  AUTHORS   Sutter,T.R., Guzman,K., Dold,K.M. and Greenlee,W.F.
  TITLE     Targets for dioxin: genes for plasminogen activator inhibitor-2 and
            interleukin-1 beta
  JOURNAL   Science 254 (5030), 415-418 (1991)
   PUBMED   1925598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U03688.1 and U56438.1.
            On Mar 14, 2001 this sequence version replaced gi:4503202.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            The enzyme encoded by this gene localizes to the endoplasmic
            reticulum and metabolizes procarcinogens such as polycyclic
            aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene
            have been associated with primary congenital glaucoma; therefore it
            is thought that the enzyme also metabolizes a signaling molecule
            involved in eye development, possibly a steroid.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..5128
                     /gene="CYP1B1"
                     /note="synonyms: CP1B, GLC3A"
                     /db_xref="GeneID:1545"
                     /db_xref="MIM:601771"
     CDS             373..2004
                     /gene="CYP1B1"
                     /note="aryl hydrocarbon hydroxylase; microsomal
                     monooxygenase; xenobiotic monooxygenase;
                     flavoprotein-linked monooxygenase; cytochrome P450,
                     subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3,
                     primary infantile);
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_component: microsome [goid 0005792] [evidence IEA];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence IEA];
                     go_function: oxygen binding [goid 0019825] [evidence TAS]
                     [pmid 9097971];
                     go_function: monooxygenase activity [goid 0004497]
                     [evidence IEA];
                     go_function: electron transporter activity [goid 0005489]
                     [evidence TAS] [pmid 8910454];
                     go_process: electron transport [goid 0006118] [evidence
                     IEA];
                     go_process: visual perception [goid 0007601] [evidence
                     TAS] [pmid 9097971];
                     go_process: eye morphogenesis (sensu Mammalia) [goid
                     0001747] [evidence TAS] [pmid 9097971]"
                     /codon_start=1
                     /product="cytochrome P450, family 1, subfamily B,
                     polypeptide 1"
                     /protein_id="NP_000095.1"
                     /db_xref="GI:4503203"
                     /db_xref="GeneID:1545"
                     /db_xref="MIM:601771"
                     /translation="MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRR
                     RQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERA
                     IHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQP
                     RSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDD
                     PEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKF
                     LRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT
                     LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFS
                     SFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDG
                     LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYG
                     LTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ"
     misc_feature    1780..1782
                     /gene="CYP1B1"
                     /note="heme binding site"
     polyA_signal    5098..5103
                     /gene="CYP1B1"
     polyA_site      5122
                     /gene="CYP1B1"
                     /evidence=experimental
ORIGIN      
        1 actctggagt gggagtggga gcgagcgctt ctgcgactcc agttgtgaga gccgcaaggg
       61 catgggaatt gacgccactc accgaccccc agtctcaatc tcaacgctgt gaggaaacct
      121 cgactttgcc aggtccccaa gggcagcggg gctcggcgag cgaggcaccc ttctccgtcc
      181 ccatcccaat ccaagcgctc ctggcactga cgacgccaag agactcgagt gggagttaaa
      241 gcttccagtg agggcagcag gtgtccaggc cgggcctgcg ggttcctgtt gacgtcttgc
      301 cctaggcaaa ggtcccagtt ccttctcgga gccggctgtc ccgcgccact ggaaaccgca
      361 cctccccgca gcatgggcac cagcctcagc ccgaacgacc cttggccgct aaacccgctg
      421 tccatccagc agaccacgct cctgctactc ctgtcggtgc tggccactgt gcatgtgggc
      481 cagcggctgc tgaggcaacg gaggcggcag ctccggtccg cgcccccggg cccgtttgcg
      541 tggccactga tcggaaacgc ggcggcggtg ggccaggcgg ctcacctctc gttcgctcgc
      601 ctggcgcggc gctacggcga cgttttccag atccgcctgg gcagctgccc catagtggtg
      661 ctgaatggcg agcgcgccat ccaccaggcc ctggtgcagc agggctcggc cttcgccgac
      721 cggccggcct tcgcctcctt ccgtgtggtg tccggcggcc gcagcatggc tttcggccac
      781 tactcggagc actggaaggt gcagcggcgc gcagcccaca gcatgatgcg caacttcttc
      841 acgcgccagc cgcgcagccg ccaagtcctc gagggccacg tgctgagcga ggcgcgcgag
      901 ctggtggcgc tgctggtgcg cggcagcgcg gacggcgcct tcctcgaccc gaggccgctg
      961 accgtcgtgg ccgtggccaa cgtcatgagt gccgtgtgtt tcggctgccg ctacagccac
     1021 gacgaccccg agttccgtga gctgctcagc cacaacgaag agttcgggcg cacggtgggc
     1081 gcgggcagcc tggtggacgt gatgccctgg ctgcagtact tccccaaccc ggtgcgcacc
     1141 gttttccgcg aattcgagca gctcaaccgc aacttcagca acttcatcct ggacaagttc
     1201 ttgaggcact gcgaaagcct tcggcccggg gccgcccccc gcgacatgat ggacgccttt
     1261 atcctctctg cggaaaagaa ggcggccggg gactcgcacg gtggtggcgc gcggctggat
     1321 ttggagaacg taccggccac tatcactgac atcttcggcg ccagccagga caccctgtcc
     1381 accgcgctgc agtggctgct cctcctcttc accaggtatc ctgatgtgca gactcgagtg
     1441 caggcagaat tggatcaggt cgtggggagg gaccgtctgc cttgtatggg tgaccagccc
     1501 aacctgccct atgtcctggc cttcctttat gaagccatgc gcttctccag ctttgtgcct
     1561 gtcactattc ctcatgccac cactgccaac acctctgtct tgggctacca cattcccaag
     1621 gacactgtgg tttttgtcaa ccagtggtct gtgaatcatg acccagtgaa gtggcctaac
     1681 ccggagaact ttgatccagc tcgattcttg gacaaggatg gcctcatcaa caaggacctg
     1741 accagcagag tgatgatttt ttcagtgggc aaaaggcggt gcattggcga agaactttct
     1801 aagatgcagc tttttctctt catctccatc ctggctcacc agtgcgattt cagggccaac
     1861 ccaaatgagc ctgcgaaaat gaatttcagt tatggtctaa ccattaaacc caagtcattt
     1921 aaagtcaatg tcactctcag agagtccatg gagctccttg atagtgctgt ccaaaattta
     1981 caagccaagg aaacttgcca ataagaagca agaggcaagc tgaaatttta gaaatattca
     2041 catcttcgga gatgaggagt aaaattcagt ttttttccag ttcctctttt gtgctgcttc
     2101 tcaattagcg tttaaggtga gcataaatca actgtccatc aggtgaggtg tgctccatac
     2161 ccagcggttc ttcatgagta gtgggctatg caggagcttc tgggagattt ttttgagtca
     2221 aagacttaaa gggcccaatg aattattata tacatactgc atcttggtta tttctgaagg
     2281 tagcattctt tggagttaaa atgcacatat agacacatac acccaaacac ttacaccaaa
     2341 ctactgaatg aagaagtatt ttggtaacca ggccattttt ggtgggaatc caagattggt
     2401 ctcccatatg cagaaataga caaaaagtat attaaacaaa gtttcagagt atattgttga
     2461 agagacagag acaagtaatt tcagtgtaaa gtgtgtgatt gaaggtgata agggaaaaga
     2521 taaagaccag aaattccctt ttcacctttt caggaaaata acttagactc tagtatttat
     2581 gggtggattt atccttttgc cttctggtat acttccttac ttttaaggat aaatcataaa
     2641 gtcagttgct caaaaagaaa tcaatagttg aattagtgag tatagtgggg ttccatgagt
     2701 tatcatgaat tttaaagtat gcattattaa attgtaaaac tccaaggtga tgttgtacct
     2761 cttttgcttg ccaaagtaca gaatttgaat tatcagcaaa gaaaaaaaaa aaagccagcc
     2821 aagctttaaa ttatgtgacc ataatgtact gatttcagta agtctcatag gttaaaaaaa
     2881 aaagtcacca aatagtgtga aatatattac ttaactgtcc gtaagcagta tattagtatt
     2941 atcttgttca ggaaaaggtt gaataatata tgccttgtgt aatattgaaa attgaaaagt
     3001 acaactaacg caaccaagtg tgctaaaaat gagcttgatt aaatcaacca cctatttttg
     3061 acatggaaat gaagcagggt ttcttttctt cactcaaatt ttggcgaatc tcaaaattag
     3121 atcctaagat gtgttcttat ttttataaca tctttattga aattctattt ataatacaga
     3181 atcttgtttt gaaaataacc taattaatat attaaaattc caaattcatg gcatgcttaa
     3241 attttaacta aattttaaag ccattctgat tattgagttc cagttgaagt tagtggaaat
     3301 ctgaacattc tcctgtggaa ggcagagaaa tctaagctgt gtctgcccaa tgaataatgg
     3361 aaaatgccat gaattacctg gatgttcttt ttacgaggtg acaagagttg gggacagaac
     3421 tcccattaca actgaccaag tttctcttct agatgatttt ttgaaagtta acattaatgc
     3481 ctgctttttg gaaagtcaga atcagaagat agtcttggaa gctgtttgga aaagacagtg
     3541 gagatgaggt cagttgtgtt ttttaagatg gcaattactt tggtagctgg gaaagcataa
     3601 agctcaaatg aaatgtatgc attcacattt agaaaagtga attgaagttt caagttttaa
     3661 agttcattgc aattaaactt ccaaagaaag ttctacagtg tcctaagtgc taagtgctta
     3721 ttacatttta ttaagctttt tggaatcttt gtaccaaaat tttaaaaaag ggagtttttg
     3781 atagttgtgt gtatgtgtgt gtggggtggg gggatggtaa gagaaaagag agaaacactg
     3841 aaaagaagga aagatggtta aacattttcc cactcattct gaattaatta atttggagca
     3901 caaaattcaa agcatggaca tttagaagaa agatgtttgg cgtagcagag ttaaatctca
     3961 aataggctat taaaaaagtc tacaacatag cagatctgtt ttgtggtttg gaatattaaa
     4021 aaacttcatg taattttatt ttaaaatttc atagctgtac ttcttgaata taaaaaatca
     4081 tgccagtatt tttaaaggca ttagagtcaa ctacacaaag caggcttgcc cagtacattt
     4141 aaattttttg gcacttgcca ttccaaaata ttatgcccca ccaaggctga gacagtgaat
     4201 ttgggctgct gtagcctatt tttttagatt gagaaatgtg tagctgcaaa aataatcatg
     4261 aaccaatctg gatgcctcat tatgtcaacc aggtccagat gtgctataat ctgtttttac
     4321 gtatgtaggc ccagtcgtca tcagatgctt gcggcaaaag aaagctgtgt ttatatggaa
     4381 gaaagtaagg tgcttggagt ttacctggct tatttaatat gcttataacc tagttaaaga
     4441 aaggaaaaga aaacaaaaaa cgaatgaaaa taactgaatt tggaggctgg agtaatcaga
     4501 ttactgcttt aatcagaaac cctcattgtg tttctaccgg agagagaatg tatttgctga
     4561 caaccattaa agtcagaagt tttactccag gttattgcaa taaagtataa tgtttattaa
     4621 atgcttcatt tgtatgtcaa agctttgact ctataagcaa attgcttttt tccaaaacaa
     4681 aaagatgtct caggtttgtt ttgtgaattt tctaaaagct ttcatgtccc agaacttagc
     4741 ctttacctgt gaagtgttac tacagcctta atattttcct agtagatcta tattagatca
     4801 aatagttgca tagcagtata tgttaatttg tgtgttttta gctgtgacac aactgtgtga
     4861 ttaaaaggta tactttagta gacatttata actcaaggat accttcttat ttaatctttt
     4921 cttatttttg tactttatca tgaatgcttt tagtgtgtgc ataatagcta cagtgcatag
     4981 ttgtagacaa agtacattct ggggaaacaa catttatatg tagcctttac tgtttgatat
     5041 accaaattaa aaaaaaattg tatctcatta cttatactgg gacaccatta ccaaaataat
     5101 aaaaatcact ttcataatct tgaaaaaa
//

LOCUS       NM_000177               2705 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens gelsolin (amyloidosis, Finnish type) (GSN), transcript
            variant 1, mRNA.
ACCESSION   NM_000177
VERSION     NM_000177.3  GI:38016941
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Boccellino,M., Giuberti,G., Quagliuolo,L., Marra,M.,
            D'Alessandro,A.M., Fujita,H., Giovane,A., Abbruzzese,A. and
            Caraglia,M.
  TITLE     Apoptosis induced by interferon-alpha and antagonized by EGF is
            regulated by caspase-3-mediated cleavage of gelsolin in human
            epidermoid cancer cells
  JOURNAL   J. Cell. Physiol. 201 (1), 71-83 (2004)
   PUBMED   15281090
  REMARK    GeneRIF: IFNalpha can induce morphological cell changes that are
            peculiar of apoptosis onset through the caspase-3-mediated cleavage
            of gelsolin.
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Klampfer,L., Huang,J., Sasazuki,T., Shirasawa,S. and Augenlicht,L.
  TITLE     Oncogenic Ras promotes butyrate-induced apoptosis through
            inhibition of gelsolin expression
  JOURNAL   J. Biol. Chem. 279 (35), 36680-36688 (2004)
   PUBMED   15213223
  REMARK    GeneRIF: gelsolin protects cells from butyrate-induced apoptosis
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   Anderson,N.L., Polanski,M., Pieper,R., Gatlin,T., Tirumalai,R.S.,
            Conrads,T.P., Veenstra,T.D., Adkins,J.N., Pounds,J.G., Fagan,R. and
            Lobley,A.
  TITLE     The human plasma proteome: a nonredundant list developed by
            combination of four separate sources
  JOURNAL   Mol. Cell Proteomics 3 (4), 311-326 (2004)
   PUBMED   14718574
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Ahn,J.S., Jang,I.S., Kim,D.I., Cho,K.A., Park,Y.H., Kim,K.,
            Kwak,C.S. and Chul Park,S.
  TITLE     Aging-associated increase of gelsolin for apoptosis resistance
  JOURNAL   Biochem. Biophys. Res. Commun. 312 (4), 1335-1341 (2003)
   PUBMED   14652020
  REMARK    GeneRIF: the observed ubiquitous increase of gelsolin in the
            senescent states of cells and tissues, and the increased
            sensitivity to apoptosis-induction by gelsolin down-regulation,
            suggests that it would be partly responsible for age-related
            apoptosis resistance
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   Ahn,J.S., Jang,I.S., Rhim,J.H., Kim,K., Yeo,E.J. and Park,S.C.
  TITLE     Gelsolin for senescence-associated resistance to apoptosis
  JOURNAL   Ann. N. Y. Acad. Sci. 1010, 493-495 (2003)
   PUBMED   15033777
  REMARK    GeneRIF: Gelsolin is involved in the apoptotic resistance in
            senescent human diploid fibroblasts.
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Huff,M.E., Page,L.J., Balch,W.E. and Kelly,J.W.
  TITLE     Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin
            proteolysis and familial amyloidosis of finnish type
  JOURNAL   J. Mol. Biol. 334 (1), 119-127 (2003)
   PUBMED   14596804
  REMARK    GeneRIF: Data suggest that mutations that diminish domain 2 Ca(2+)
            binding allow furin access to an otherwise protected cleavage site,
            initiating the proteolytic cascade that leads to gelsolin
            amyloidogenesis and familial amyloidosis of Finnish type.
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Irobi,E., Burtnick,L.D., Urosev,D., Narayan,K. and Robinson,R.C.
  TITLE     From the first to the second domain of gelsolin: a common path on
            the surface of actin?
  JOURNAL   FEBS Lett. 552 (2-3), 86-90 (2003)
   PUBMED   14527665
  REMARK    GeneRIF: 2.6 A resolution crystal structure of a complex formed
            between G-actin and gelsolin fragment Met25-Gln160
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   Narayan,K., Chumnarnsilpa,S., Choe,H., Irobi,E., Urosev,D.,
            Lindberg,U., Schutt,C.E., Burtnick,L.D. and Robinson,R.C.
  TITLE     Activation in isolation: exposure of the actin-binding site in the
            C-terminal half of gelsolin does not require actin
  JOURNAL   FEBS Lett. 552 (2-3), 82-85 (2003)
   PUBMED   14527664
  REMARK    GeneRIF: structure of the isolated C-terminal half of gelsolin
            (G4-G6) at 2.0 A resolution in the presence of Ca(2+) ions
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Lagarrigue,E., Maciver,S.K., Fattoum,A., Benyamin,Y. and Roustan,C.
  TITLE     Co-operation of domain-binding and calcium-binding sites in the
            activation of gelsolin
  JOURNAL   Eur. J. Biochem. 270 (10), 2236-2243 (2003)
   PUBMED   12752443
  REMARK    GeneRIF: analysis of domain-binding and calcium-binding sites in
            gelsolin
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   Kiselar,J.G., Janmey,P.A., Almo,S.C. and Chance,M.R.
  TITLE     Visualizing the Ca2+-dependent activation of gelsolin by using
            synchrotron footprinting
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (7), 3942-3947 (2003)
   PUBMED   12655044
  REMARK    GeneRIF: A visualization of the Ca2+-dependent activation of this
            protein by using synchrotron footprinting.
REFERENCE   11 (bases 1 to 2705)
  AUTHORS   Vartanian,A.A.
  TITLE     Gelsolin and plasminogen activator inhibitor-1 are Ap3A-binding
            proteins
  JOURNAL   Ital. J. Biochem. 52 (1), 9-16 (2003)
   PUBMED   12833632
  REMARK    GeneRIF: Gelsolin and plasminogen activator inhibitor-1 have roles
            as Ap3A-binding proteins
REFERENCE   12 (bases 1 to 2705)
  AUTHORS   Sagawa,N., Fujita,H., Banno,Y., Nozawa,Y., Katoh,H. and Kuzumaki,N.
  TITLE     Gelsolin suppresses tumorigenicity through inhibiting PKC
            activation in a human lung cancer cell line, PC10
  JOURNAL   Br. J. Cancer 88 (4), 606-612 (2003)
   PUBMED   12592377
  REMARK    GeneRIF: Gelsolin suppresses tumorigenicity through inhibiting PKC
            activation in a human lung cancer cell line, PC10.
REFERENCE   13 (bases 1 to 2705)
  AUTHORS   Haga,K.
  TITLE     The mechanism for reduced expression of gelsolin, tumor suppressor
            protein, in bladder cancer
  JOURNAL   Hokkaido Igaku Zasshi 78 (1), 29-37 (2003)
   PUBMED   12613021
  REMARK    GeneRIF: Its reduced expression in bladder cancer is regulated by
            DNA methylation, histone acetylation and chromatin remodeling.
REFERENCE   14 (bases 1 to 2705)
  AUTHORS   Choe,H., Burtnick,L.D., Mejillano,M., Yin,H.L., Robinson,R.C. and
            Choe,S.
  TITLE     The calcium activation of gelsolin: insights from the 3A structure
            of the G4-G6/actin complex
  JOURNAL   J. Mol. Biol. 324 (4), 691-702 (2002)
   PUBMED   12460571
  REMARK    GeneRIF: Calcium activation of gelsolin: X-Ray crystallography
            model of the G4-G6/actin complex.
REFERENCE   15 (bases 1 to 2705)
  AUTHORS   Xian,W. and Janmey,P.A.
  TITLE     Dissecting the gelsolin-polyphosphoinositide interaction and
            engineering of a polyphosphoinositide-sensitive gelsolin C-terminal
            half protein
  JOURNAL   J. Mol. Biol. 322 (4), 755-771 (2002)
   PUBMED   12270712
  REMARK    GeneRIF: explores the structure-function relationship of the
            gelsolin-PPI interaction
REFERENCE   16 (bases 1 to 2705)
  AUTHORS   Dong,Y., Asch,H.L., Ying,A. and Asch,B.B.
  TITLE     Molecular mechanism of transcriptional repression of gelsolin in
            human breast cancer cells
  JOURNAL   Exp. Cell Res. 276 (2), 328-336 (2002)
   PUBMED   12027462
  REMARK    GeneRIF: ATF-1 DNA-binding activity was abundant in breast cancer
            cells and correlated inversely with gelsolin mRNA levels. This
            suggests a role for ATF-1 in gelsolin promoter silencing, in
            contrast to its transactivating effect on various other promoters.
REFERENCE   17 (bases 1 to 2705)
  AUTHORS   Fujita,H.
  TITLE     An actin-regulatory protein, gelsolin functions as a regulator of
            cell growth and apoptosis
  JOURNAL   Seikagaku 74 (2), 135-139 (2002)
   PUBMED   11925941
  REMARK    GeneRIF: functions as a regulator of cell growth and apoptosis
REFERENCE   18 (bases 1 to 2705)
  AUTHORS   Kazmirski,S.L., Isaacson,R.L., An,C., Buckle,A., Johnson,C.M.,
            Daggett,V. and Fersht,A.R.
  TITLE     Loss of a metal-binding site in gelsolin leads to familial
            amyloidosis-Finnish type
  JOURNAL   Nat. Struct. Biol. 9 (2), 112-116 (2002)
   PUBMED   11753432
  REMARK    GeneRIF: crystal structure: loss of a metal-binding site leads to
            familial amyloidosis-Finnish type
REFERENCE   19 (bases 1 to 2705)
  AUTHORS   Vasconcellos,C.A., Allen,P.G., Wohl,M.E., Drazen,J.M., Janmey,P.A.
            and Stossel,T.P.
  TITLE     Reduction in viscosity of cystic fibrosis sputum in vitro by
            gelsolin
  JOURNAL   Science 263 (5149), 969-971 (1994)
   PUBMED   8310295
REFERENCE   20 (bases 1 to 2705)
  AUTHORS   Yu,F.X., Sun,H.Q., Janmey,P.A. and Yin,H.L.
  TITLE     Identification of a polyphosphoinositide-binding sequence in an
            actin monomer-binding domain of gelsolin
  JOURNAL   J. Biol. Chem. 267 (21), 14616-14621 (1992)
   PUBMED   1321812
REFERENCE   21 (bases 1 to 2705)
  AUTHORS   Hiltunen,T., Kiuru,S., Hongell,V., Helio,T., Palo,J. and
            Peltonen,L.
  TITLE     Finnish type of familial amyloidosis: cosegregation of
            Asp187----Asn mutation of gelsolin with the disease in three large
            families
  JOURNAL   Am. J. Hum. Genet. 49 (3), 522-528 (1991)
   PUBMED   1652889
REFERENCE   22 (bases 1 to 2705)
  AUTHORS   Kwiatkowski,D.J., Stossel,T.P., Orkin,S.H., Mole,J.E., Colten,H.R.
            and Yin,H.L.
  TITLE     Plasma and cytoplasmic gelsolins are encoded by a single gene and
            contain a duplicated actin-binding domain
  JOURNAL   Nature 323 (6087), 455-458 (1986)
   PUBMED   3020431
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AI742454.1, X04412.1 and
            BC026033.1.
            On Oct 29, 2003 this sequence version replaced gi:31542863.
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2705
                     /gene="GSN"
                     /db_xref="GeneID:2934"
                     /db_xref="MIM:137350"
     CDS             48..2396
                     /gene="GSN"
                     /note="isoform a is encoded by transcript variant 1;
                     go_component: cytosol [goid 0005829] [evidence IDA] [pmid
                     3020431];
                     go_component: extracellular [goid 0005576] [evidence IDA]
                     [pmid 3020431];
                     go_component: extracellular [goid 0005576] [evidence NAS]
                     [pmid 14718574];
                     go_component: actin cytoskeleton [goid 0015629] [evidence
                     TAS] [pmid 1321812];
                     go_function: actin binding [goid 0003779] [evidence IEA];
                     go_function: calcium ion binding [goid 0005509] [evidence
                     TAS] [pmid 1321812];
                     go_process: actin filament severing [goid 0051014]
                     [evidence IDA] [pmid 3020431];
                     go_process: actin filament polymerization [goid 0030041]
                     [evidence IDA] [pmid 3020431];
                     go_process: barbed-end actin filament capping [goid
                     0051016] [evidence TAS] [pmid 1321812]"
                     /codon_start=1
                     /product="gelsolin isoform a"
                     /protein_id="NP_000168.1"
                     /db_xref="GI:4504165"
                     /db_xref="GeneID:2934"
                     /db_xref="MIM:137350"
                     /translation="MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRV
                     PEARPNSMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQ
                     LRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGY
                     FKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFIL
                     DLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGP
                     KPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFIL
                     DHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQF
                     FKNWRDPDQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIW
                     RIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAI
                     LTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLF
                     QVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV
                     LRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIE
                     EVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDR
                     RTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA"
ORIGIN      
        1 acccgaggcc gcggctgccg actgggtccc ctgccgctgt cgccaccatg gctccgcacc
       61 gccccgcgcc cgcgctgctt tgcgcgctgt ccctggcgct gtgcgcgctg tcgctgcccg
      121 tccgcgcggc cactgcgtcg cggggggcgt cccaggcggg ggcgccccag gggcgggtgc
      181 ccgaggcgcg gcccaacagc atggtggtgg aacaccccga gttcctcaag gcagggaagg
      241 agcctggcct gcagatctgg cgtgtggaga agttcgatct ggtgcccgtg cccaccaacc
      301 tttatggaga cttcttcacg ggcgacgcct acgtcatcct gaagacagtg cagctgagga
      361 acggaaatct gcagtatgac ctccactact ggctgggcaa tgagtgcagc caggatgaga
      421 gcggggcggc cgccatcttt accgtgcagc tggatgacta cctgaacggc cgggccgtgc
      481 agcaccgtga ggtccagggc ttcgagtcgg ccaccttcct aggctacttc aagtctggcc
      541 tgaagtacaa gaaaggaggt gtggcatcag gattcaagca cgtggtaccc aacgaggtgg
      601 tggtgcagag actcttccag gtcaaagggc ggcgtgtggt ccgtgccacc gaggtacctg
      661 tgtcctggga gagcttcaac aatggcgact gcttcatcct ggacctgggc aacaacatcc
      721 accagtggtg tggttccaac agcaatcggt atgaaagact gaaggccaca caggtgtcca
      781 agggcatccg ggacaacgag cggagtggcc gggcccgagt gcacgtgtct gaggagggca
      841 ctgagcccga ggcgatgctc caggtgctgg gccccaagcc ggctctgcct gcaggtaccg
      901 aggacaccgc caaggaggat gcggccaacc gcaagctggc caagctctac aaggtctcca
      961 atggtgcagg gaccatgtcc gtctccctcg tggctgatga gaaccccttc gcccaggggg
     1021 ccctgaagtc agaggactgc ttcatcctgg accacggcaa agatgggaaa atctttgtct
     1081 ggaaaggcaa gcaggcaaac acggaggaga ggaaggctgc cctcaaaaca gcctctgact
     1141 tcatcaccaa gatggactac cccaagcaga ctcaggtctc ggtccttcct gagggcggtg
     1201 agaccccact gttcaagcag ttcttcaaga actggcggga cccagaccag acagatggcc
     1261 tgggcttgtc ctacctttcc agccatatcg ccaacgtgga gcgggtgccc ttcgacgccg
     1321 ccaccctgca cacctccact gccatggccg cccagcacgg catggatgac gatggcacag
     1381 gccagaaaca gatctggaga atcgaaggtt ccaacaaggt gcccgtggac cctgccacat
     1441 atggacagtt ctatggaggc gacagctaca tcattctgta caactaccgc catggtggcc
     1501 gccaggggca gataatctat aactggcagg gtgcccagtc tacccaggat gaggtcgctg
     1561 catctgccat cctgactgct cagctggatg aggagctggg aggtacccct gtccagagcc
     1621 gtgtggtcca aggcaaggag cccgcccacc tcatgagcct gtttggtggg aagcccatga
     1681 tcatctacaa gggcggcacc tcccgcgagg gcgggcagac agcccctgcc agcacccgcc
     1741 tcttccaggt ccgcgccaac agcgctggag ccacccgggc tgttgaggta ttgcctaagg
     1801 ctggtgcact gaactccaac gatgcctttg ttctgaaaac cccctcagcc gcctacctgt
     1861 gggtgggtac aggagccagc gaggcagaga agacgggggc ccaggagctg ctcagggtgc
     1921 tgcgggccca acctgtgcag gtggcagaag gcagcgagcc agatggcttc tgggaggccc
     1981 tgggcgggaa ggctgcctac cgcacatccc cacggctgaa ggacaagaag atggatgccc
     2041 atcctcctcg cctctttgcc tgctccaaca agattggacg ttttgtgatc gaagaggttc
     2101 ctggtgagct catgcaggaa gacctggcaa cggatgacgt catgcttctg gacacctggg
     2161 accaggtctt tgtctgggtt ggaaaggatt ctcaagaaga agaaaagaca gaagccttga
     2221 cttctgctaa gcggtacatc gagacggacc cagccaatcg ggatcggcgg acgcccatca
     2281 ccgtggtgaa gcaaggcttt gagcctccct cctttgtggg ctggttcctt ggctgggatg
     2341 atgattactg gtctgtggac cccttggaca gggccatggc tgagctggct gcctgaggag
     2401 gggcagggcc cacccatgtc accggtcagt gccttttgga actgtccttc cctcaaagag
     2461 gccttagagc gagcagagca gctctgctat gagtgtgtgt gtgtgtgtgt gttgtttctt
     2521 tttttttttt ttacagtatc caaaaatagc cctgcaaaaa ttcagagtcc ttgcaaaatt
     2581 gtctaaaatg tcagtgtttg ggaaattaaa tccaataaaa acattttgaa gtgtgaaaaa
     2641 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaa
//

LOCUS       NM_000183               1991 bp    mRNA    linear   PRI 14-DEC-2004
DEFINITION  Homo sapiens hydroxyacyl-Coenzyme A
            dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A
            hydratase (trifunctional protein), beta subunit (HADHB), mRNA.
ACCESSION   NM_000183
VERSION     NM_000183.1  GI:4504326
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Spiekerkoetter,U., Khuchua,Z., Yue,Z., Bennett,M.J. and
            Strauss,A.W.
  TITLE     General mitochondrial trifunctional protein (TFP) deficiency as a
            result of either alpha- or beta-subunit mutations exhibits similar
            phenotypes because mutations in either subunit alter TFP complex
            expression and subunit turnover
  JOURNAL   Pediatr. Res. 55 (2), 190-196 (2004)
   PUBMED   14630990
  REMARK    GeneRIF: Both alpha- and beta-subunit mutations result in TFP
            complex instability, demonstrating that the mechanism of disease is
            the same in alpha- or beta-mutation-derived disease and explaining
            the biochemical and clinical similarities.
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Adams,D.J., Beveridge,D.J., van der Weyden,L., Mangs,H.,
            Leedman,P.J. and Morris,B.J.
  TITLE     HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of
            human renin mRNA and differentially modulate renin expression
  JOURNAL   J. Biol. Chem. 278 (45), 44894-44903 (2003)
  MEDLINE   22957244
   PUBMED   12933794
  REMARK    GeneRIF: HADHB trifunctional enzyme, human renin, and
            poly(C)-binding protein are novel renin mRNA-binding proteins that
            target a cis-element in the 3'-UTR of renin mRNA and regulate renin
            production
REFERENCE   3  (bases 1 to 1991)
  AUTHORS   Orii,K.E., Aoyama,T., Wakui,K., Fukushima,Y., Miyajima,H.,
            Yamaguchi,S., Orii,T., Kondo,N. and Hashimoto,T.
  TITLE     Genomic and mutational analysis of the mitochondrial trifunctional
            protein beta-subunit (HADHB) gene in patients with trifunctional
            protein deficiency
  JOURNAL   Hum. Mol. Genet. 6 (8), 1215-1224 (1997)
  MEDLINE   97402202
   PUBMED   9259266
REFERENCE   4  (bases 1 to 1991)
  AUTHORS   Aoyama,T., Wakui,K., Orii,K.E., Hashimoto,T. and Fukushima,Y.
  TITLE     Fluorescence in situ hybridization mapping of the alpha and beta
            subunits (HADHA and HADHB) of human mitochondrial fatty acid
            beta-oxidation multienzyme complex to 2p23 and their evolution
  JOURNAL   Cytogenet. Cell Genet. 79 (3-4), 221-224 (1997)
  MEDLINE   98266894
   PUBMED   9605857
REFERENCE   5  (bases 1 to 1991)
  AUTHORS   Middleton,B.
  TITLE     The mitochondrial long-chain trifunctional enzyme: 2-enoyl-CoA
            hydratase, 3-hydroxyacyl-CoA dehydrogenase and 3-oxoacyl-CoA
            thiolase
  JOURNAL   Biochem. Soc. Trans. 22 (2), 427-431 (1994)
  MEDLINE   95046784
   PUBMED   7958339
REFERENCE   6  (bases 1 to 1991)
  AUTHORS   Kamijo,T., Wanders,R.J., Saudubray,J.M., Aoyama,T., Komiyama,A. and
            Hashimoto,T.
  TITLE     Mitochondrial trifunctional protein deficiency. Catalytic
            heterogeneity of the mutant enzyme in two patients
  JOURNAL   J. Clin. Invest. 93 (4), 1740-1747 (1994)
  MEDLINE   94216523
   PUBMED   8163672
REFERENCE   7  (sites)
  AUTHORS   Kamijo,T., Aoyama,T., Komiyama,A. and Hashimoto,T.
  TITLE     Structural analysis of cDNAs for subunits of human mitochondrial
            fatty acid beta-oxidation trifunctional protein
  JOURNAL   Biochem. Biophys. Res. Commun. 199 (2), 818-825 (1994)
  MEDLINE   94183263
   PUBMED   8135828
REFERENCE   8  (bases 1 to 1991)
  AUTHORS   Carpenter,K., Pollitt,R.J. and Middleton,B.
  TITLE     Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a
            multifunctional membrane-bound beta-oxidation enzyme of
            mitochondria
  JOURNAL   Biochem. Biophys. Res. Commun. 183 (2), 443-448 (1992)
  MEDLINE   92198421
   PUBMED   1550553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D16481.1.
            
            Summary: The HADHA (MIM 600890) and HADHB genes encode the alpha
            and beta subunits of the mitochondrial trifunctional protein,
            respectively. The heterocomplex contains 4 alpha and 4 beta
            subunits and catalyzes 3 steps in the beta-oxidation of fatty
            acids, including the long-chain 3-hydroxyl-CoA dehydrogenase step.
            The beta subunit harbors the 3-ketoacyl-CoA thiolase activity
            (Kamijo et al., 1994 [PubMed 8163672]).[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23"
     gene            1..1991
                     /gene="HADHB"
                     /note="synonyms: HADH, MSTP029"
                     /db_xref="GeneID:3032"
                     /db_xref="MIM:143450"
     CDS             47..1471
                     /gene="HADHB"
                     /EC_number="2.3.1.16"
                     /note="3-ketoacyl-Coenzyme A thiolase; trifunctional
                     protein, beta subunit;
                     go_component: mitochondrial membrane [goid 0005740]
                     [evidence TAS] [pmid 1550553];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: acyltransferase activity [goid 0008415]
                     [evidence IEA];
                     go_function: enoyl-CoA hydratase activity [goid 0004300]
                     [evidence TAS] [pmid 1550553];
                     go_function: acetyl-CoA C-acyltransferase activity [goid
                     0003988] [evidence TAS] [pmid 8135828];
                     go_function: 3-hydroxyacyl-CoA dehydrogenase activity
                     [goid 0003857] [evidence TAS] [pmid 1550553];
                     go_process: fatty acid metabolism [goid 0006631] [evidence
                     IEA];
                     go_process: fatty acid beta-oxidation [goid 0006635]
                     [evidence TAS] [pmid 1550553]"
                     /codon_start=1
                     /product="hydroxyacyl dehydrogenase, subunit B"
                     /protein_id="NP_000174.1"
                     /db_xref="GI:4504327"
                     /db_xref="GeneID:3032"
                     /db_xref="MIM:143450"
                     /translation="MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKK
                     TLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYII
                     FGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVI
                     VAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFS
                     TSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVT
                     KDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPK
                     AYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKA
                     MDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGG
                     QYGLVAACAAGGQGHAMIVEAYPK"
     sig_peptide     47..145
                     /gene="HADHB"
     mat_peptide     146..1468
                     /gene="HADHB"
                     /product="hydroxyacyl dehydrogenase, subunit B"
ORIGIN      
        1 cttgctccga gagggagtcc tcgcggacgt cagccaagat tccagaatga ctatcttgac
       61 ttaccccttt aaaaatcttc ccactgcatc aaaatgggcc ctcagatttt ccataagacc
      121 tctgagctgt tcctcccagc tacgagctgc cccagctgtc cagaccaaaa cgaagaagac
      181 gttagccaaa cccaatataa ggaatgttgt ggtggtggat ggtgttcgca ctccattttt
      241 gctgtctggc acttcatata aagacctgat gccacatgat ttggctagag cagcgcttac
      301 gggtttgttg catcggacca gtgtccctaa ggaagtagtt gattatatca tctttggtac
      361 agttattcag gaagtgaaaa caagcaatgt ggctagagag gctgcccttg gagctggctt
      421 ctctgacaag actcctgctc acactgtcac catggcttgt atctctgcca accaagccat
      481 gaccacaggt gttggcttga ttgcttctgg ccagtgtgat gtgatcgtgg caggtggtgt
      541 tgagttgatg tccgatgtcc ctattcgtca ctcaaggaaa atgagaaaac tgatgcttga
      601 tctcaataag gccaaatcta tgggccagcg actgtcttta atctctaaat tccgatttaa
      661 tttcctagca cctgagctcc ctgcggtttc tgagttctcc accagtgaga ccatgggcca
      721 ctctgcagac cgactggccg ctgcctttgc tgtttctcgg ctggaacagg atgaatatgc
      781 actgcgctct cacagtctag ccaagaaggc acaggatgaa ggactccttt ctgatgtggt
      841 acccttcaaa gtaccaggaa aagatacagt taccaaagat aatggcatcc gtccttcctc
      901 actggagcag atggccaaac taaaacctgc attcatcaag ccctacggca cagtgacagc
      961 tgcaaattct tctttcttga ctgatggtgc atctgcaatg ttaatcatgg cggaggaaaa
     1021 ggctctggcc atgggttata agccgaaggc atatttgagg gattttatgt atgtgtctca
     1081 ggatccaaaa gatcaactat tacttggacc aacatatgct actccaaaag ttctagaaaa
     1141 ggcaggattg accatgaatg atattgatgc ttttgaattt catgaagctt tctcgggtca
     1201 gattttggca aattttaaag ccatggattc tgattggttt gcagaaaact acatgggtag
     1261 aaaaaccaag gttggattgc ctcctttgga gaagtttaat aactggggtg gatctctgtc
     1321 cctgggacac ccatttggag ccactggctg caggttggtc atggctgctg ccaacagatt
     1381 acggaaagaa ggaggccagt atggcttagt ggctgcgtgt gcagctggag ggcagggcca
     1441 tgctatgata gtggaagctt atccaaaata atagatccag aagaagtgac ctgaagtttc
     1501 tgtgcaacac tcacactagg caatgccatt tcaatgcatt actaaatgac atttgtagtt
     1561 cctagctcct cttaggaaaa cagttcttgt ggccttctat taaatagttt gcacttaagc
     1621 cttgccagtg ttctgagctt ttcaataatc agtttactgc tctttcaggg atttctaagc
     1681 caccagaatc tcacatgaga tgtgtgggtg gttgtttttg gtctctgttg tcactaaaga
     1741 ctaaatgagg gtttgcagtt gggaaagagg tcaactgaga tttggaaatc atctttgtaa
     1801 tatttgcaaa ttatacttgt tcttatctgt gtcctaaaga tgtgttctct ataaaataca
     1861 aaccaacgtg cctaattaat tatggaaaaa taattcagaa tctaaacacc actgaaaact
     1921 tataaaaaat gtttagatac ataaatatgg tggtcagcgt taataaagtg gagaaatatt
     1981 ggaaaaaaaa a
//

LOCUS       NM_000611               7633 bp    mRNA    linear   PRI 16-DEC-2004
DEFINITION  Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonal
            antibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), transcript
            variant 2, mRNA.
ACCESSION   NM_000611
VERSION     NM_000611.4  GI:42716300
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7633)
  AUTHORS   Brown,G., Jeffree,C.E., McDonald,T., Rixon,H.W., Aitken,J.D. and
            Sugrue,R.J.
  TITLE     Analysis of the interaction between respiratory syncytial virus and
            lipid-rafts in Hep2 cells during infection
  JOURNAL   Virology 327 (2), 175-185 (2004)
   PUBMED   15351205
  REMARK    GeneRIF: During respiratory syncytial virus assembly in Hep2 cells,
            the cellular distribution of the complement regulatory protein,
            CD59 changes and high levels of this cellular protein are
            incorporated into mature virus filaments.
REFERENCE   2  (bases 1 to 7633)
  AUTHORS   Qin,X., Goldfine,A., Krumrei,N., Grubissich,L., Acosta,J.,
            Chorev,M., Hays,A.P. and Halperin,J.A.
  TITLE     Glycation inactivation of the complement regulatory protein CD59: a
            possible role in the pathogenesis of the vascular complications of
            human diabetes
  JOURNAL   Diabetes 53 (10), 2653-2661 (2004)
   PUBMED   15448097
  REMARK    GeneRIF: Glycation inactivation of hCD59 leads to increased
            membrane attack complex deposition may contribute to the extensive
            vascular pathology that complicates human diabetes.
REFERENCE   3  (bases 1 to 7633)
  AUTHORS   Shimo,K., Mizuno,M., Nasu,J., Hiraoka,S., Makidono,C., Okazaki,H.,
            Yamamoto,K., Okada,H., Fujita,T. and Shiratori,Y.
  TITLE     Complement regulatory proteins in normal human esophagus and
            esophageal squamous cell carcinoma
  JOURNAL   J. Gastroenterol. Hepatol. 19 (6), 643-647 (2004)
   PUBMED   15151618
  REMARK    GeneRIF: Significant difference in intensity of the staining of
            CD55 and CD46 among cells in various layers of normal esophageal
            mucosa and esophageal carcinoma cells, but not in the staining of
            CD59.
REFERENCE   4  (bases 1 to 7633)
  AUTHORS   Storstein,A., Knudsen,A., Bj, Meri,S. and Vedeler,C.
  TITLE     Heterogeneous expression of CD59 on human Purkinje cells
  JOURNAL   Neurosci. Lett. 362 (1), 21-25 (2004)
   PUBMED   15147772
  REMARK    GeneRIF: Presence of CD59 on Purkinje cells at various levels in
            eight of 14 cases with no cerebellar pathology suggests that
            Purkinje cells not expressing CD59 could be especially prone to
            complement-mediated damage.
REFERENCE   5  (bases 1 to 7633)
  AUTHORS   Harrower,T.P., Richards,A., Cruz,G., Copeman,L., Dunnett,S.B. and
            Barker,R.A.
  TITLE     Complement regulatory proteins are expressed at low levels in
            embryonic human, wild type and transgenic porcine neural tissue
  JOURNAL   Xenotransplantation 11 (1), 60-71 (2004)
   PUBMED   14962294
  REMARK    GeneRIF: Complement regulatory proteins such as MCP and CD59 are
            expressed in the human and wild-type embryonic brain.
REFERENCE   6  (bases 1 to 7633)
  AUTHORS   Marcenaro,E., Augugliaro,R., Falco,M., Castriconi,R., Parolini,S.,
            Sivori,S., Romeo,E., Millo,R., Moretta,L., Bottino,C. and
            Moretta,A.
  TITLE     CD59 is physically and functionally associated with natural
            cytotoxicity receptors and activates human NK cell-mediated
            cytotoxicity
  JOURNAL   Eur. J. Immunol. 33 (12), 3367-3376 (2003)
  MEDLINE   22995281
   PUBMED   14635045
  REMARK    GeneRIF: CD59 is physically associated with NKp46 and NKp30 and
            activate human nk cell-mediated cytotoxicity.
REFERENCE   7  (bases 1 to 7633)
  AUTHORS   Richaud-Patin,Y., P, Carrillo-Maravilla,E., Rodriguez,A.B.,
            Simon,A.J., Cabiedes,J., Jakez-Ocampo,J., Llorente,L. and Ruiz-Arg.
  TITLE     Deficiency of red cell bound CD55 and CD59 in patients with
            systemic lupus erythematosus
  JOURNAL   Immunol. Lett. 88 (2), 95-99 (2003)
  MEDLINE   22763158
   PUBMED   12880676
  REMARK    GeneRIF: Although CD55 and CD59 deficiency in primary or secondary
            AIHA, it appears that this defect plays a facilitator rather than a
            triggering role for the hemolytic process.
REFERENCE   8  (bases 1 to 7633)
  AUTHORS   Ghiran,I., Klickstein,L.B. and Nicholson-Weller,A.
  TITLE     Calreticulin is at the surface of circulating neutrophils and uses
            CD59 as an adaptor molecule
  JOURNAL   J. Biol. Chem. 278 (23), 21024-21031 (2003)
  MEDLINE   22662252
   PUBMED   12646570
  REMARK    GeneRIF: CD59 is an adaptor for ecto-calreticulin in neutrophils
REFERENCE   9  (bases 1 to 7633)
  AUTHORS   Clayton,A., Harris,C.L., Court,J., Mason,M.D. and Morgan,B.P.
  TITLE     Antigen-presenting cell exosomes are protected from
            complement-mediated lysis by expression of CD55 and CD59
  JOURNAL   Eur. J. Immunol. 33 (2), 522-531 (2003)
  MEDLINE   22532513
   PUBMED   12645951
  REMARK    GeneRIF: Antigen-presenting cell exosomes are protected from
            complement-mediated lysis by expression of CD55 and CD59.
REFERENCE   10 (bases 1 to 7633)
  AUTHORS   Gazouli,M., Kokotas,S., Zoumpourlis,V., Zacharatos,P., Mariatos,G.,
            Kletsas,D., Perunovic,B., Athanasiou,A., Kittas,C. and Gorgoulis,V.
  TITLE     The complement inhibitor CD59 and the lymphocyte
            function-associated antigen-3 (LFA-3, CD58) genes possess
            functional binding sites for the p53 tumor suppressor protein
  JOURNAL   Anticancer Res. 22 (6C), 4237-4241 (2002)
  MEDLINE   22441230
   PUBMED   12553064
  REMARK    GeneRIF: The complement inhibitor CD59 and the lymphocyte
            function-associated antigen-3 (LFA-3, CD58) genes possess
            functional binding sites for the p53 tumor suppressor protein.
REFERENCE   11 (bases 1 to 7633)
  AUTHORS   Nguyen,D.H. and Hildreth,J.E.
  TITLE     Evidence for budding of human immunodeficiency virus type 1
            selectively from glycolipid-enriched membrane lipid rafts
  JOURNAL   J. Virol. 74 (7), 3264-3272 (2000)
  MEDLINE   20173717
   PUBMED   10708443
REFERENCE   12 (bases 1 to 7633)
  AUTHORS   Bickmore,W.A., Longbottom,D., Oghene,K., Fletcher,J.M. and van
            Heyningen,V.
  TITLE     Colocalization of the human CD59 gene to 11p13 with the MIC11 cell
            surface antigen
  JOURNAL   Genomics 17 (1), 129-135 (1993)
  MEDLINE   94010876
   PUBMED   7691713
REFERENCE   13 (bases 1 to 7633)
  AUTHORS   Heckl-Ostreicher,B., Ragg,S., Drechsler,M., Scherthan,H. and
            Royer-Pokora,B.
  TITLE     Localization of the human CD59 gene by fluorescence in situ
            hybridization and pulsed-field gel electrophoresis
  JOURNAL   Cytogenet. Cell Genet. 63 (3), 144-146 (1993)
  MEDLINE   93251820
   PUBMED   7683594
REFERENCE   14 (bases 1 to 7633)
  AUTHORS   Tone,M., Walsh,L.A. and Waldmann,H.
  TITLE     Gene structure of human CD59 and demonstration that discrete mRNAs
            are generated by alternative polyadenylation
  JOURNAL   J. Mol. Biol. 227 (3), 971-976 (1992)
  MEDLINE   93021133
   PUBMED   1383553
REFERENCE   15 (bases 1 to 7633)
  AUTHORS   Petranka,J.G., Fleenor,D.E., Sykes,K., Kaufman,R.E. and Rosse,W.F.
  TITLE     Structure of the CD59-encoding gene: further evidence of a
            relationship to murine lymphocyte antigen Ly-6 protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (17), 7876-7879 (1992)
  MEDLINE   92390353
   PUBMED   1381503
REFERENCE   16 (bases 1 to 7633)
  AUTHORS   Sawada,R., Ohashi,K., Anaguchi,H., Okazaki,H., Hattori,M.,
            Minato,N. and Naruto,M.
  TITLE     Isolation and expression of the full-length cDNA encoding CD59
            antigen of human lymphocytes
  JOURNAL   DNA Cell Biol. 9 (3), 213-220 (1990)
  MEDLINE   90253615
   PUBMED   1692709
REFERENCE   17 (bases 1 to 7633)
  AUTHORS   Philbrick,W.M., Palfree,R.G., Maher,S.E., Bridgett,M.M., Sirlin,S.
            and Bothwell,A.L.
  TITLE     The CD59 antigen is a structural homologue of murine Ly-6 antigens
            but lacks interferon inducibility
  JOURNAL   Eur. J. Immunol. 20 (1), 87-92 (1990)
  MEDLINE   90168959
   PUBMED   1689664
REFERENCE   18 (bases 1 to 7633)
  AUTHORS   Davies,A., Simmons,D.L., Hale,G., Harrison,R.A., Tighe,H.,
            Lachmann,P.J. and Waldmann,H.
  TITLE     CD59, an LY-6-like protein expressed in human lymphoid cells,
            regulates the action of the complement membrane attack complex on
            homologous cells
  JOURNAL   J. Exp. Med. 170 (3), 637-654 (1989)
  MEDLINE   89361238
   PUBMED   2475570
REFERENCE   19 (bases 1 to 7633)
  AUTHORS   Sawada,R., Ohashi,K., Okano,K., Hattori,M., Minato,N. and Naruto,M.
  TITLE     Complementary DNA sequence and deduced peptide sequence for
            CD59/MEM-43 antigen, the human homologue of murine lymphocyte
            antigen Ly-6C
  JOURNAL   Nucleic Acids Res. 17 (16), 6728 (1989)
  MEDLINE   89386002
   PUBMED   2476718
REFERENCE   20 (bases 1 to 7633)
  AUTHORS   Okada,H., Nagami,Y., Takahashi,K., Okada,N., Hideshima,T.,
            Takizawa,H. and Kondo,J.
  TITLE     20 KDa homologous restriction factor of complement resembles T cell
            activating protein
  JOURNAL   Biochem. Biophys. Res. Commun. 162 (3), 1553-1559 (1989)
  MEDLINE   89350983
   PUBMED   2475111
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AU136899.1, BC001506.2,
            BX475103.1, AW166662.1, BM551313.1, CF529941.1, BQ440441.1,
            BM829941.1, AI147924.1, BM457931.1, BE899630.1, BM911556.1,
            BU154979.1, BM724931.1, BG284181.1, BC033226.1 and BM680161.1.
            On Feb 20, 2004 this sequence version replaced gi:39725685.
FEATURES             Location/Qualifiers
     source          1..7633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..7633
                     /gene="CD59"
                     /note="synonyms: MIN1, MIN2, MIN3, MIC11, MSK21, MGC2354,
                     PROTECTIN"
                     /db_xref="GeneID:966"
                     /db_xref="MIM:107271"
     CDS             116..502
                     /gene="CD59"
                     /note="Antigen identified by monoclonal antibody 16.3A5;
                     CD59 protein;
                     go_component: plasma membrane [goid 0005886] [evidence
                     NAS] [pmid 1381503];
                     go_component: membrane fraction [goid 0005624] [evidence
                     TAS] [pmid 1381503];
                     go_process: immune response [goid 0006955] [evidence NR];
                     go_process: blood coagulation [goid 0007596] [evidence
                     TAS] [pmid 1381503];
                     go_process: cell surface receptor linked signal
                     transduction [goid 0007166] [evidence TAS] [pmid 7691713]"
                     /codon_start=1
                     /product="CD59 antigen p18-20"
                     /protein_id="NP_000602.1"
                     /db_xref="GI:10835165"
                     /db_xref="GeneID:966"
                     /db_xref="MIM:107271"
                     /translation="MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNC
                     SSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLEN
                     GGTSLSEKTVLLLVTPFLAAAWSLHP"
ORIGIN      
        1 gggccggggg gcggagcctt gcgggctgga gcgaaagaat gcgggggctg agcgcagaag
       61 cggctcgagg ctggaagagg atcttgggcg ccgccaggtt ctgtggacaa tcacaatggg
      121 aatccaagga gggtctgtcc tgttcgggct gctgctcgtc ctggctgtct tctgccattc
      181 aggtcatagc ctgcagtgct acaactgtcc taacccaact gctgactgca aaacagccgt
      241 caattgttca tctgattttg atgcgtgtct cattaccaaa gctgggttac aagtgtataa
      301 caagtgttgg aagtttgagc attgcaattt caacgacgtc acaacccgct tgagggaaaa
      361 tgagctaacg tactactgct gcaagaagga cctgtgtaac tttaacgaac agcttgaaaa
      421 tggtgggaca tccttatcag agaaaacagt tcttctgctg gtgactccat ttctggcagc
      481 agcctggagc cttcatccct aagtcaacac caggagagct tctcccaaac tccccgttcc
      541 tgcgtagtcc gctttctctt gctgccacat tctaaaggct tgatattttc caaatggatc
      601 ctgttgggaa agaataaaat tagcttgagc aacctggcta agatagaggg gctctgggag
      661 actttgaaga ccagtcctgt ttgcagggaa gccccacttg aaggaagaag tctaagagtg
      721 aagtaggtgt gacttgaact agattgcatg cttcctcctt tgctcttggg aagaccagct
      781 ttgcagtgac agcttgagtg ggttctctgc agccctcaga ttatttttcc tctggctcct
      841 tggatgtagt cagttagcat cattagtaca tctttggagg gtggggcagg agtatatgag
      901 catcctctct cacatggaac gctttcataa acttcaggga tcccgtgttg ccatggaggc
      961 atgccaaatg ttccatatgt gggtgtcagt cagggacaac aagatcctta atgcagagct
     1021 agaggacttc tggcagggaa gtggggaagt gttccagata gcagggcatg aaaacttaga
     1081 gaggtacaag tggctgaaaa tcgagttttt cctctgtctt taaattttat atgggctttg
     1141 ttatcttcca ctggaaaagt gtaatagcat acatcaatgg tgtgttaaag ctatttcctt
     1201 gccttttttt tattggaatg gtaggatatc ttggctttgc cacacacagt tacagagtga
     1261 acactctact acatgtgact ggcagtatta agtgtgctta ttttaaatgt tactggtaga
     1321 aaggcagttc aggtatgtgt gtatatagta tgaatgcagt ggggacaccc tttgtggtta
     1381 cagtttgaga cttccaaagg tcatccttaa taacaacaga tctgcagggg tatgttttac
     1441 catctgcatc cagcctcctg ctaactccta gctgactcag catagattgt ataaaatacc
     1501 tttgtaacgg ctcttagcac actcacagat gtttgaggct ttcagaagct cttctaaaaa
     1561 atgatacaca cctttcacaa gggcaaactt tttccttttc cctgtgtatt ctagtgaatg
     1621 aatctcaaga ttcagtagac ctaatgacat ttgtatttta tgatcttggc tgtatttaat
     1681 ggcataggct gacttttgca gatggaggaa tttcttgatt aatgttgaaa aaaaaccctt
     1741 gattatactc tgttggacaa accgagtgca atgaatgatg cttttctgaa aatgaaatat
     1801 aacaagtggg tgaatgtggt tatggccgaa aaggatatgc agtatgctta atggtagcaa
     1861 ctgaaagaag acatcctgag cagtgccagc tttcttctgt tgatgccgtt ccctgaacat
     1921 aggaaaatag aaacttgctt atcaaaactt agcattacct tggtgctctg tgttctctgt
     1981 tagctcagtg tctttcctta catcaatagg tttttttttt tttttttggc ctgaggaagt
     2041 actgaccatg cccacagcca ccggctgagc aaagaagctc atttcatgtg agttctaagg
     2101 aatgagaaac aattttgatg aatttaagca gaaaatgaat ttctgggaac ttttttgggg
     2161 gcggggggtt ggggaattca gccacactcc agaaagccag gagtcgacag ttttggaagc
     2221 ctctctcagg attgagattc taggatgaga ttggcttact gctatcttgt gtcatgtacc
     2281 cactttttgg ccagactaca ctgggaagaa ggtagtcctc taaagcaaaa tctgagtgcc
     2341 actaaatggg gagatggggc tgttaagctg tccaaatcaa caagggtcat ataaatggcc
     2401 ttaaactttg gggttgcttt ctgcaaaaag ttgctgtgac tcatgccata gacaaggttg
     2461 agtgcctgga cccaaaggca atactgtaat gtaaagacat ttatagtact aggcaaacag
     2521 caccccaggt actccaggcc ctcctggctg gagagggctg tggcaataga aaattagtgc
     2581 caactgcagt gagtcagcct aggttaaata gagagtgtaa gagtgctgga caggaacctc
     2641 caccctcatg tcacatttct tcaatgtgac ccttctggcc cctctcctcc tgacagcgga
     2701 acaatgactg ccccgatagg tgaggctgga ggaagaatca gtcctgtcct tggcaagctc
     2761 ttcactatga cagtaaaggc tctctgcctg ctgccaaggc ctgtgacttt ctaacctggc
     2821 ctcacgctgg gtaagcttaa ggtagaggtg caggattagc aagcccacct ggctaccagg
     2881 ccgacagcta catcctccaa ctgaccctga tcaacgaaga gggattcatg tgtctgtctc
     2941 agttggttcc aaatgaaacc agggagcagg ggagttagga atcgaacacc agtcatgcct
     3001 actggctctc tgctcgagag ccaataccct gtgccctcca ctcatctgga tttacaggaa
     3061 ctgtcatagt gttcagtatt gggtggtgat aagcccattg gattgtcccc ttggggggat
     3121 gagctagggg tgcaaggaac acctgatgag tagataagtg gagctcatgg tatttcctga
     3181 aagatgctaa tctatttgcc aaacttggtc ttgaatgtac tgggggcttc aaggtatggg
     3241 tatatttttc ttgtgtcctt gcagttagcc cccatgtctt atgtgtgtcc tgaaaaaata
     3301 agagcctgcc caagactttg ggcctcttga cagaattaac cacttttata catctgagtt
     3361 ctcttggtaa gttctttagc agtgttcaaa gtctactagc tcgcattagt ttctgttgct
     3421 gccaacagat ctgaactaat gctaacagat ccccctgagg gattcttgat gggctgagca
     3481 gctggctgga gctagtactg actgacattc attgtgatga gggcagcttt ctggtacagg
     3541 attctaagct ctatgtttta tatacatttt catctgtact tgcacctcac tttacacaag
     3601 aggaaactat gcaaagttag ctggatcgct caaggtcact taggtaagtt ggcaagtcca
     3661 tgcttcccac tcagctcctc aggtcagcaa gtctacttct ctgcctattt tgtatactct
     3721 ctttaatatg tgcctagctt tggaaagtct agaatgggtc cctggtgcct ttttactttg
     3781 aagaaatcag tttctgcctc tttttggaaa agaaaacaaa gtgcaattgt tttttactgg
     3841 aaagttaccc aatagcatga ggtgaacagg acgtagttag gccttcctgt aaacagaaaa
     3901 tcatatcaaa acactatctt cccatctgtt tctcaatgcc tgctacttct tgtagatatt
     3961 tcatttcagg agagcagcag ttaaacccgt ggattttgta gttaggaacc tgggttcaaa
     4021 ccctcttcca ctaattggct atgtctctgg acaagttttt tttttttttt ttttttaaac
     4081 cctttctgaa ctttcacttt ctatgtctac ctcaaagaat tgttgtgagg cttgagataa
     4141 tgcatttgta aagggtctgc cagataggaa gatgctagtt atggatttac aaggttgtta
     4201 aggctgtaag agtctaaaac ctacagtgaa tcacaatgca tttaccccca ctgacttgga
     4261 cataagtgaa aactagccag aagtctcttt ttcaaattac ttacaggtta ttcaatataa
     4321 aatttttgta atggataatc ttatttatct aaactaaagc ttcctgttta tacacactcc
     4381 tgttattctg ggataagata aatgaccaca gtaccttaat ttctaggtgg gtgcctgtga
     4441 tggttcattg taggtaagga cattttctct ttttcagcag ctgtgtaggt ccagagcctc
     4501 tgggagagga ggggggtagc atgcacccag caggggactg aactgggaaa ctcaaggttc
     4561 tttttactgt ggggtagtga gctgcctttc tgtgatcggt ttccctaggg atgttgctgt
     4621 tcccctcctt gctattcgca gctacataca acgtggccaa ccccagtagg ctgatcctat
     4681 atatgatcag tgctggtgct gactctcaat agccccaccc aagctggcta taggtttaca
     4741 gatacattaa ttaggcaacc taaaatattg atgctggtgt tggtgtgaca taatgctatg
     4801 gccagaactg aaacttagag ttataattca tgtattaggg ttctccagag ggacagaatt
     4861 agtaggatat atgtatatat gaaagggagg ttattaggga gaactggctc ccacagttag
     4921 aaggcgaagt cgcacaatag gccgtctgca agctgggtta gagagaagcc agtagtggct
     4981 cagcctgagt tcaaaaacct caaaactggg gaagctgaca gtgcagccag ccttcagtct
     5041 gtggccaaag gcccaagagc ccctggcaac caacccactg gtgcaagtcc tagattccaa
     5101 aggctgaaga acctggagtc tgatgtccaa gagcaggaag agtggaagaa agccagaaga
     5161 ctcagcaaac aaggtagaca gtgtctacca ccatagtggc cataccaaag aggctaccga
     5221 ttccttcctg ctacctggat ccctgaagtt gccctggtct ctgcaccttc taaacctagt
     5281 tcttaagagc tttccattac atgagctgtc tcaaagccct ccaataaatt ctcagtgtaa
     5341 gcttctgttg cttgtggaca gaaaattctg acagacctac cctataagtg ttactgtcag
     5401 gataacatga gaacgcacaa cagtaagtgg tcactaagtg ttagctacgg ttattttgcc
     5461 caaggtagca tggctagttg atgccggttg atggggctta aacccagctc cctcatcttc
     5521 caggcctctg tactccctat tccactaaac tacctctcag gtttattttt ttaaattctt
     5581 actctgcaag tacataggac cacatttacc tgggaaaaca agaataaagg ctgctctgca
     5641 ttttttagaa acttttttga aagggagatg ggaatgcctg cacccccaag tccagaccaa
     5701 cacaatggtt aattgagatg aataataaag gaaagactgt tctgggcttc ccagaatagc
     5761 ttggtcctta aattgtggca caaacaacct cctgtcagag ccagcctcct gccaggaaga
     5821 ggggtaggag actagaggcc gtgtgtgcag ccttgccctg aaggctaggg tgacaatttg
     5881 gaggctgtcc aaacaccctg gcctctagag ctggcctgtc tatttgaaat gccggctctg
     5941 atgctaatcg gcgaccctca ggcaagttac ttaaccttac atgcctcagt tttctcatct
     6001 ggaaaatgag aaccctaggt ttagggttgt tagaaaagtt aaatgagtta agacaagtgc
     6061 ctgggacaca gtagcctctt gtgtgtgttt atcattatgt cctcagcagg tcgtagaagc
     6121 agcttctcag gtgtgaggct ggcgcattat ctggagtggg ttgggttttc taggatggac
     6181 cccctgctgc attttcctca ttcatccacc agggcttaat ggggaatcaa ggaatccatg
     6241 tgtaactgta taataactgt agccacactc caatgaccac ctactagttg tccctggcac
     6301 tgcttataca tatgtccatc aaatcaatcc tatgaagtag atactgtctt cattttatag
     6361 atcagagaca attggggttc agagagctga tgtgattttc ccagggtcac agagagtccc
     6421 agattcaggc acaactcttg tattccaaga cacaaccact acatgtccaa aggctgccca
     6481 gagccaccgg gcacggcaaa ttgtgacata tccctaaaga ggctgagcac ctggtcagga
     6541 tctgatggct gacagtgtgt ccagatgcag agctggagtg ggggagggga aggggggctc
     6601 cttgggacag agaaggcttt ctgtgctttc tctgaaggga gcagtctgag gaccaaggga
     6661 acccggcaaa cagcacctca ggtactccag gccctcctgg ctggagaggg ctgtggcaat
     6721 ggaaaattag tgccaactgc aatgagtcag cctcggttaa atagagagtg aagaatgctg
     6781 gacaggaacc tccaccctca tgtcacattt cttcagtgtg acccttctgg cccctctcct
     6841 cctgacagcg gaacaatgac tgccccgata ggtgaggctg gaggaagaat cagtcctgtc
     6901 cttggcaagc tcttcactat gacagtaaag gctctctgcc tgctgccaag gcctgtgact
     6961 ttctaacctg gcctcacgct gggtaagctt aaggtagagg tgcaggatta gcaagcccac
     7021 ctggctacca ggccgacagc tacatctttc aactgaccct gatcaacgaa gagggacttg
     7081 tgtctctcag ttggttccaa atgaaaccag ggagcagggg cgttaggaag ctccaacagg
     7141 atggtactta atggggcatt tgagtggaga ggtaggtgac atagtgcttt ggagcccagg
     7201 gagggaaagg ttctgctgaa gttgaattca agactgttct ttcatcacaa acttgagttt
     7261 cctggacatt tgtttgcaga aacaaccgta gggttttgcc ttaacctcgt gggtttatta
     7321 ttacctcata gggactttgc ctcctgacag cagtttatgg gtgttcattg tggcacttga
     7381 gttttcttgc atacttgtta gagaaaccaa gtttgtcatc aacttcttat ttaaccccct
     7441 ggctataact tcatggatta tgttataatt aagccatcca gagtaaaatc tgtttagatt
     7501 atcttggagt aagggggaaa aaatctgtaa ttttttctcc tcaactagat atatacataa
     7561 aaaatgattg tattgcttca tttaaaaaat ataacgcaaa atctcttttc cttctaaaaa
     7621 aaaaaaaaaa aaa
//

LOCUS       NM_000696               2713 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens aldehyde dehydrogenase 9 family, member A1 (ALDH9A1),
            mRNA.
ACCESSION   NM_000696
VERSION     NM_000696.2  GI:25777738
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Vaz,F.M., Fouchier,S.W., Ofman,R., Sommer,M. and Wanders,R.J.
  TITLE     Molecular and biochemical characterization of rat
            gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for
            the involvement of human aldehyde dehydrogenase 9 in carnitine
            biosynthesis
  JOURNAL   J. Biol. Chem. 275 (10), 7390-7394 (2000)
   PUBMED   10702312
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Lin,S.W., Chen,J.C., Hsu,L.C., Hsieh,C.L. and Yoshida,A.
  TITLE     Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA
            sequence, genomic organization, polymorphism, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 34 (3), 376-380 (1996)
   PUBMED   8786138
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Kikonyogo,A. and Pietruszko,R.
  TITLE     Aldehyde dehydrogenase from adult human brain that dehydrogenates
            gamma-aminobutyraldehyde: purification, characterization, cloning
            and distribution
  JOURNAL   Biochem. J. 316 (Pt 1), 317-324 (1996)
   PUBMED   8645224
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   McPherson,J.D., Wasmuth,J.J., Kurys,G. and Pietruszko,R.
  TITLE     Human aldehyde dehydrogenase: chromosomal assignment of the gene
            for the isozyme that metabolizes gamma-aminobutyraldehyde
  JOURNAL   Hum. Genet. 93 (2), 211-212 (1994)
   PUBMED   8112751
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Kurys,G., Shah,P.C., Kikonygo,A., Reed,D., Ambroziak,W. and
            Pietruszko,R.
  TITLE     Human aldehyde dehydrogenase. cDNA cloning and primary structure of
            the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde
  JOURNAL   Eur. J. Biochem. 218 (2), 311-320 (1993)
   PUBMED   8269919
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Kurys,G., Ambroziak,W. and Pietruszko,R.
  TITLE     Human aldehyde dehydrogenase. Purification and characterization of
            a third isozyme with low Km for gamma-aminobutyraldehyde
  JOURNAL   J. Biol. Chem. 264 (8), 4715-4721 (1989)
   PUBMED   2925663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U34252.1.
            On Nov 27, 2002 this sequence version replaced gi:4502046.
            
            Summary: This protein belongs to the aldehyde dehydrogenase family
            of proteins. It has a high activity for oxidation of
            gamma-aminobutyraldehyde and other amino aldehydes. The enzyme
            catalyzes the dehydrogenation of gamma-aminobutyraldehyde to
            gamma-aminobutyric acid (GABA). This isozyme is a tetramer of
            identical 54-kD subunits.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2713
                     /gene="ALDH9A1"
                     /note="synonyms: E3, ALDH4, ALDH7, ALDH9, TMABADH"
                     /db_xref="GeneID:223"
                     /db_xref="MIM:602733"
     CDS             378..1862
                     /gene="ALDH9A1"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.19"
                     /EC_number="1.2.1.47"
                     /note="gamma-aminobutyraldehyde dehydrogenase;
                     4-trimethylaminobutyraldehyde dehydrogenase; aldehyde
                     dehydrogenase E3 isozyme; aldehyde dehydrogenase (NAD+);
                     R-aminobutyraldehyde dehydrogenase;
                     go_function: oxidoreductase activity [goid 0016491]
                     [evidence IEA];
                     go_function: electron transporter activity [goid 0005489]
                     [evidence TAS] [pmid 2925663];
                     go_function: aldehyde dehydrogenase (NAD) activity [goid
                     0004029] [evidence IEA];
                     go_function: aminobutyraldehyde dehydrogenase activity
                     [goid 0019145] [evidence IEA];
                     go_process: aldehyde metabolism [goid 0006081] [evidence
                     TAS] [pmid 8645224]"
                     /codon_start=1
                     /product="aldehyde dehydrogenase 9A1"
                     /protein_id="NP_000687.2"
                     /db_xref="GI:25777739"
                     /db_xref="GeneID:223"
                     /db_xref="MIM:602733"
                     /translation="MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFT
                     CSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKS
                     IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF
                     QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQF
                     LCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA
                     LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRP
                     HLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEI
                     FGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV
                     SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF"
     polyA_signal    2674..2679
                     /gene="ALDH9A1"
     polyA_site      2696
                     /gene="ALDH9A1"
                     /evidence=experimental
ORIGIN      
        1 ggatcctagg atgcttacat gcaatgatga acccgaaaac acttgcaaag tgctacgcaa
       61 atattgatca cgaagaagga agtcctcttc ccgcctggag actgtgtggg gtatggcggg
      121 gtggtgggga gaatgtggtg tcttgctcca ccctcctggc gaggggaggg cctggcctgg
      181 accgcagagg aatcgagtga ctgcccctaa aatctcctag aaccgatccc gcggccccgc
      241 ccctcccgcg gccccgcccc tcccgcggcc cgtcagcctc tgccgcggag ctgcgtccgc
      301 cactcatgtt tctccgagca ggcctggccg cgctctcccc gcttcttcgc agtcttcggc
      361 cctctcctgt cgccgccatg agcactggca ccttcgtcgt gtcgcagccg ctcaattacc
      421 gcggcggggc ccgcgtggag ccggcggacg cctccggtac cgagaaagct ttcgagccag
      481 caaccggccg agtgatagct actttcacat gttcaggaga aaaggaagta aatttggctg
      541 ttcaaaatgc aaaggctgct tttaaaatat ggagtcaaaa atctggcatg gagcgttgcc
      601 gaatcctttt ggaggctgcc aggataataa gggaacggga ggatgaaatt gctactatgg
      661 agtgcatcaa caatggcaag tccatctttg aggcccgctt ggacattgac atttcctggc
      721 agtgcctgga gtattatgcg ggcttggctg catccatggc tggtgaacac atccagctcc
      781 caggtggatc gtttggttat accagaagag aaccacttgg ggtatgtgtg ggaataggag
      841 catggaacta cccctttcag attgcctctt ggaagtcggc tccagcatta gcctgtggta
      901 atgccatggt ctttaaacct tctcccttta cacctgtttc tgcattgcta ctggctgaaa
      961 tctacagtga ggctggtgta cctcctgggc tcttcaatgt ggtgcaggga ggggctgcca
     1021 caggccagtt tctgtgtcag catcccgatg tggccaaagt ctccttcact ggaagtgtgc
     1081 ccactggcat gaagatcatg gagatgtcag ctaaaggaat caaacctgtt accttggaac
     1141 ttggaggcaa atctccactc atcatcttct cagactgtga tatgaacaat gctgtaaagg
     1201 gggcgctgat ggccaacttc ctcacacaag gccaggtttg ctgtaatggc acaagagtat
     1261 ttgtgcagaa agaaattctt gataaattta cagaggaagt ggtgaaacag acccaaagga
     1321 ttaaaattgg agatcccctt ctggaagata caaggatggg tccactcatc aaccgaccac
     1381 acctggagcg agtccttggg tttgtcaaag tggcaaagga gcagggtgct aaagtgttat
     1441 gtggtggaga tatatatgta cctgaagatc ccaaattaaa ggatggatat tacatgagac
     1501 cttgtgtatt aactaattgc agagacgaca tgacctgtgt gaaggaagag atctttgggc
     1561 ctgttatgtc cattttatca tttgacactg aagctgaggt tctagaaaga gccaatgata
     1621 ccacttttgg actagcagct ggcgtcttta ccagggacat ccaacgggct catagagtgg
     1681 tagctgagct tcaggctggg acgtgcttca ttaacaacta taacgtcagc ccagtggagt
     1741 tgccctttgg tggatataag aagtcaggat ttggcagaga gaacggccgt gtgacaatcg
     1801 aatattattc acagctgaag actgtgtgtg tggagatggg tgatgtggaa tctgcttttt
     1861 gaaaacctgc agtgaaacct attgacatgg ccacgctgtg gaatgatgtg aattggccct
     1921 gtttacagag gcagtacaac tgaatgttat tttacatcca gaattttggc gttcagtata
     1981 agagaatggt tcatgttact ctttctctct ccatcagctt cctcactgaa aatgtgcatt
     2041 aagtgccttg tagatactaa tcaagaaagc tgtgattctc ctcaaagcgt atttttgtga
     2101 aatcttttaa gagccagtaa catacttcta gagaacagga aaagagacta ggataataca
     2161 tcttccacac atttggccca ctgataatgt taattctctg gcgtatttca aagaacttgt
     2221 tcctggctga tccaagtgca gtggtattta caactaattg atcacaacca gtttgtagat
     2281 ttctttgttc cttctccatt cccactgctt cacttgccta gtcttgaaga aaaaaaacaa
     2341 aaaacaaaaa aaaaccttgt tcctttatag gttcctggta gaatcagtag agatgatttc
     2401 agctcattga cattttttta agctatatcc ccttgtcatt ccattgagaa agctgacaac
     2461 tgggataggg aggggattag ataatagatg gggtcaaatt ctgtgtgaat gtgaacttgc
     2521 ctagtaagca ctttgtctct gttcactact gcgatagagg aaatctatct ccctatcttg
     2581 ggtccttgaa ctacagcctg ctgtcttaca ccagtggagc taccctttaa atgtacaaat
     2641 tatttgtatg ctaatgtaat atggtgaaat taaaataaat cacactgtta attgttaaaa
     2701 aaaaaaaaaa aaa
//

LOCUS       NM_000966               2900 bp    mRNA    linear   PRI 13-JAN-2005
DEFINITION  Homo sapiens retinoic acid receptor, gamma (RARG), mRNA.
ACCESSION   NM_000966 XM_352902
VERSION     NM_000966.3  GI:38505166
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Pinaire,J., Chou,W.Y., Morton,M., You,M., Zeng,Y., Cho,W.K.,
            Galli,A., Everett,L., Breen,H., Dumaual,N., Smith,J.R. and Crabb,D.
  TITLE     Identification of a retinoid receptor response element in the human
            aldehyde dehydrogenase-2 promoter
  JOURNAL   Alcohol. Clin. Exp. Res. 27 (12), 1860-1866 (2003)
   PUBMED   14691372
  REMARK    GeneRIF: In a 9-cis retinoic acid-dependent fashion in cells in
            vitro, retinoic acid receptor isoform gamma stimulates the
            expression of reporter constructs containing the site that binds
            aldehyde dehydrogenase-2.
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Andersson,E., Rosdahl,I., T and Vahlquist,A.
  TITLE     Differential effects of UV irradiation on nuclear retinoid receptor
            levels in cultured keratinocytes and melanocytes
  JOURNAL   Exp. Dermatol. 12 (5), 563-571 (2003)
  MEDLINE   23067511
   PUBMED   14705796
  REMARK    GeneRIF: depletion of vitamin A and retinoid receptors by UV
            irradiation, together with unchanged or even increased c-Jun
            levels, might seriously interfere with retinoid signaling and thus
            promote future tumor development, especially in keratinocytes.
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Farboud,B., Hauksdottir,H., Wu,Y. and Privalsky,M.L.
  TITLE     Isotype-restricted corepressor recruitment: a constitutively closed
            helix 12 conformation in retinoic acid receptors beta and gamma
            interferes with corepressor recruitment and prevents
            transcriptional repression
  JOURNAL   Mol. Cell. Biol. 23 (8), 2844-2858 (2003)
  MEDLINE   22552644
   PUBMED   12665583
  REMARK    GeneRIF: RAR beta and RAR gamma receptors appear to adopt a
            constitutively closed helix 12 conformation in the absence of
            hormone that may approximate the conformation of RAR alpha when
            bound to hormone agonist.
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Hauksdottir,H., Farboud,B. and Privalsky,M.L.
  TITLE     Retinoic acid receptors beta and gamma do not repress, but instead
            activate target gene transcription in both the absence and presence
            of hormone ligand
  JOURNAL   Mol. Endocrinol. 17 (3), 373-385 (2003)
  MEDLINE   22497702
   PUBMED   12554770
  REMARK    GeneRIF: RARgamma interact only weakly with SMRT.
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Richter,F., Joyce,A., Fromowitz,F., Wang,S., Watson,J., Watson,R.,
            Irwin,R.J. Jr. and Huang,H.F.
  TITLE     Immunohistochemical localization of the retinoic Acid receptors in
            human prostate
  JOURNAL   J. Androl. 23 (6), 830-838 (2002)
  MEDLINE   22286505
   PUBMED   12399530
  REMARK    GeneRIF: Present throughout the epithelium with minimal nuclear
            accumulation. Increased in basal and luminal epithelial nuclei in
            glands with benign prostatic hyperplasia.
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Klaholz,B. and Moras,D.
  TITLE     C-H...O hydrogen bonds in the nuclear receptor RARgamma--a
            potential tool for drug selectivity
  JOURNAL   Structure (Camb.) 10 (9), 1197-1204 (2002)
  MEDLINE   22210212
   PUBMED   12220491
  REMARK    GeneRIF: The 1.4 A resolution crystal structure of the ligand
            binding domain of the retinoic acid receptor RARgamma complexed
            with the retinoid SR11254 reveals several types of C-H...O hydrogen
            bonds
REFERENCE   7  (bases 1 to 2900)
  AUTHORS   Pettersson,F., Dalgleish,A.G., Bissonnette,R.P. and Colston,K.W.
  TITLE     Retinoids cause apoptosis in pancreatic cancer cells via activation
            of RAR-gamma and altered expression of Bcl-2/Bax
  JOURNAL   Br. J. Cancer 87 (5), 555-561 (2002)
  MEDLINE   22176356
   PUBMED   12189556
  REMARK    GeneRIF: Retinoids cause apoptosis in pancreatic cancer cells via
            activation of RAR-gamma and altered expression of Bcl-2/Bax.
REFERENCE   8  (bases 1 to 2900)
  AUTHORS   Boudjelal,M., Voorhees,J.J. and Fisher,G.J.
  TITLE     Retinoid signaling is attenuated by proteasome-mediated degradation
            of retinoid receptors in human keratinocyte HaCaT cells
  JOURNAL   Exp. Cell Res. 274 (1), 130-137 (2002)
  MEDLINE   21846032
   PUBMED   11855864
  REMARK    GeneRIF: Retinoid signaling is attenuated by retinoic acid-induced
            proteasome-mediated degradation of RARG in human keratocytes.
REFERENCE   9  (bases 1 to 2900)
  AUTHORS   Renaud,J.P., Rochel,N., Ruff,M., Vivat,V., Chambon,P.,
            Gronemeyer,H. and Moras,D.
  TITLE     Crystal structure of the RAR-gamma ligand-binding domain bound to
            all-trans retinoic acid
  JOURNAL   Nature 378 (6558), 681-689 (1995)
  MEDLINE   96107307
   PUBMED   7501014
REFERENCE   10 (bases 1 to 2900)
  AUTHORS   Lehmann,J.M., Zhang,X.K. and Pfahl,M.
  TITLE     RAR gamma 2 expression is regulated through a retinoic acid
            response element embedded in Sp1 sites
  JOURNAL   Mol. Cell. Biol. 12 (7), 2976-2985 (1992)
  MEDLINE   92318914
   PUBMED   1320193
REFERENCE   11 (bases 1 to 2900)
  AUTHORS   Mattei,M.G., Rivi, Krust,A., Ingvarsson,S., Vennstr, Islam,M.Q.,
            Levan,G., Kautner,P., Zelent,A., Chambon,P. et al.
  TITLE     Chromosomal assignment of retinoic acid receptor (RAR) genes in the
            human, mouse, and rat genomes
  JOURNAL   Genomics 10 (4), 1061-1069 (1991)
  MEDLINE   92009907
   PUBMED   1655630
REFERENCE   12 (bases 1 to 2900)
  AUTHORS   Lehmann,J.M., Hoffmann,B. and Pfahl,M.
  TITLE     Genomic organization of the retinoic acid receptor gamma gene
  JOURNAL   Nucleic Acids Res. 19 (3), 573-578 (1991)
  MEDLINE   91187677
   PUBMED   1849262
REFERENCE   13 (bases 1 to 2900)
  AUTHORS   Ishikawa,T., Umesono,K., Mangelsdorf,D.J., Aburatani,H.,
            Stanger,B.Z., Shibasaki,Y., Imawari,M., Evans,R.M. and Takaku,F.
  TITLE     A functional retinoic acid receptor encoded by the gene on human
            chromosome 12
  JOURNAL   Mol. Endocrinol. 4 (6), 837-844 (1990)
  MEDLINE   91042616
   PUBMED   2172793
REFERENCE   14 (bases 1 to 2900)
  AUTHORS   Gigu, Shago,M., Zirngibl,R., Tate,P., Rossant,J. and Varmuza,S.
  TITLE     Identification of a novel isoform of the retinoic acid receptor
            gamma expressed in the mouse embryo
  JOURNAL   Mol. Cell. Biol. 10 (5), 2335-2340 (1990)
  MEDLINE   90220619
   PUBMED   2157970
REFERENCE   15 (bases 1 to 2900)
  AUTHORS   Kastner,P., Krust,A., Mendelsohn,C., Garnier,J.M., Zelent,A.,
            Leroy,P., Staub,A. and Chambon,P.
  TITLE     Murine isoforms of retinoic acid receptor gamma with specific
            patterns of expression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2700-2704 (1990)
  MEDLINE   90207264
   PUBMED   2157210
REFERENCE   16 (bases 1 to 2900)
  AUTHORS   Krust,A., Kastner,P., Petkovich,M., Zelent,A. and Chambon,P.
  TITLE     A third human retinoic acid receptor, hRAR-gamma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5310-5314 (1989)
  MEDLINE   89315787
   PUBMED   2546152
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AL701206.1, M24857.1 and
            BC019098.2.
            On or before Dec 18, 2003 this sequence version replaced
            gi:37542853, gi:21359851.
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..2900
                     /gene="RARG"
                     /note="synonyms: RARC, NR1B3"
                     /db_xref="GeneID:5916"
                     /db_xref="MIM:180190"
     CDS             430..1794
                     /gene="RARG"
                     /note="retinoic acid receptor, gamma polypeptide; retinoic
                     acid receptor gamma-1; retinoic acid receptor gamma 2;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_function: steroid hormone receptor activity [goid
                     0003707] [evidence IEA];
                     go_function: retinoic acid receptor activity [goid
                     0003708] [evidence TAS] [pmid 2157970];
                     go_process: development [goid 0007275] [evidence TAS]
                     [pmid 2157970];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="retinoic acid receptor, gamma"
                     /protein_id="NP_000957.1"
                     /db_xref="GI:4506423"
                     /db_xref="GeneID:5916"
                     /db_xref="MIM:180190"
                     /translation="MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSP
                     SFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHY
                     GVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAV
                     RNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADH
                     RVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRIC
                     TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAI
                     CLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK
                     GAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGL
                     KSPA"
ORIGIN      
        1 gcagagtcag tgtgcggttt gggagaaaat gtgtcggata ttttggggcg gtcacgtggg
       61 cgggcgggct ccgagaggcc ccgggacagt cccagcctag agccgtgccc ccccaggagc
      121 cccccagtac ggcgagcccc ggacattgcg acgctccatc caagagactg cccgacgccg
      181 ggacctcggg gctccgccgc ctcccttccc cctcccactc cagctacggc ccagttccct
      241 caacctgacc cagtatgtag aagccagtct ctgcaggcgg ccagcgggac ttttggaggc
      301 ccagtgggca ggccaggcag ggcgggtacg gagcctccca ggctggggca gtgggcatgg
      361 gcaggggctg tggctgaaga cctcgcccgc ccactgcaga ctccagggga ctctcacacc
      421 gcagctgcca tggccaccaa taaggagcga ctctttgcgg ctggtgccct ggggcctgga
      481 tctggctacc caggggcagg tttccccttc gccttcccag gggcactcag ggggtctccg
      541 cctttcgaga tgctgagccc tagcttccgg ggcctgggcc agcctgacct ccccaaggag
      601 atggcctctc tgtcggtgga gacacagagc accagctcag aggagatggt gcccagctcg
      661 ccctcgcccc ctccgcctcc tcgggtctac aagccatgct tcgtgtgcaa tgacaagtcc
      721 tctggctacc actatggggt cagctcttgt gaaggctgca agggcttctt tcgccgaagc
      781 atccagaaga acatggtgta cacgtgtcac cgcgacaaaa actgtatcat caacaaggtg
      841 accaggaatc gctgccagta ctgccggcta cagaagtgct tcgaagtggg catgtccaag
      901 gaagctgtgc gaaatgaccg gaacaagaag aagaaagagg tgaaggaaga agggtcacct
      961 gacagctatg agctgagccc tcagttagaa gagctcatca ccaaggtcag caaagcccat
     1021 caggagactt tcccctcgct ctgccagctg ggcaagtata ccacgaactc cagtgcagac
     1081 caccgcgtgc agctggatct ggggctgtgg gacaagttca gtgagctggc taccaagtgc
     1141 atcatcaaga tcgtggagtt tgccaagcgg ttgcctggct ttacagggct cagcattgct
     1201 gaccagatca ctctgctcaa agctgcctgc ctagatatcc tgatgctgcg tatctgcaca
     1261 aggtacaccc cagagcagga caccatgacc ttctccgacg ggctgaccct gaaccggacc
     1321 cagatgcaca atgccggctt cgggcccctc acagaccttg tctttgcctt tgctgggcag
     1381 ctcctgcccc tggagatgga tgacaccgag acagggctgc tcagcgccat ctgcctcatc
     1441 tgcggagacc gcatggacct ggaggagccc gaaaaagtgg acaagctgca ggagccactg
     1501 ctggaagccc tgaggctgta cgcccggcgc cggcggccca gccagcccta catgttccca
     1561 aggatgctaa tgaaaatcac cgacctccgg ggcatcagca ctaagggagc tgaaagggcc
     1621 attactctga agatggagat tccaggcccg atgcctccct taatccgaga gatgctggag
     1681 aaccctgaaa tgtttgagga tgactcctcg cagcctggtc cccaccccaa tgcctctagc
     1741 gaggatgagg ttcctggggg ccagggcaaa gggggcctga agtccccagc ctgaccaggg
     1801 cccctgacct ccccgctgtg ggggttgggg cttcaggcag cagactgacc atctcccaga
     1861 ccgccagtga ctgggggagg acctgctctg ccctctcccc accccttcca atgagctcct
     1921 tgtttttgcc aaagtttcta ggggtgcctc tgtgttcatc cccttcctga tctaaccggc
     1981 tccctcgcca gtcccggggg cctgccctgc tcccaccagg agagagggca aagggatgag
     2041 cctgggtttg gactctaaaa tctcagcact gccccatggg tcctagactt cccagggcaa
     2101 gaggaagacc ctgccattcc acagcccctt cctctgccag gtgcttggct ctctgagagc
     2161 aaacaggaac actagagacc aaaaagggga caaaggagaa gggctgagcc caccttcttg
     2221 ctcctaccct tggtgcctaa tgctgtgtga tgcacctgca gggtgtgtgc tagcctctgt
     2281 gccccgtcct tgtgccaggt caaggtgggg gcaggctggg ccctgcattt ctggggcagg
     2341 aacagagggt gaaagggaca gatagatgca ggtccattct gcacctcttg gctcgggtgc
     2401 agagttcacc ctgtgccctc cgttataagt ccctccccca gccctgtcat gtgccttggg
     2461 ctcctcctgc cctccatctc agccattggg gcagggaccc tcctacacta cagaggggcc
     2521 aggggatccc tctctcccta gtgccttcca ccctttactc cccagagcag cttggcccag
     2581 ggagggggga tgctgcttag ctgatcccgc cctgacccag aggaagcctc tatttattta
     2641 ttagcttttg tttacaccgt ggaattgacc ccttcctcca ggggtcttgg gtgggggagc
     2701 ccagggcccc tgtgacccct cctttcttcc tccaatcccc agtttgtatt tagctgccaa
     2761 ataagattcc cattggctcc ctgtgttctc ttggggggtc agggtgctgt cccctcccct
     2821 ctgtttacat ctcccctcta ccccgctgta tcgcatattg ctgagttttc tatttttgca
     2881 aaataaagtg atggaaactc
//

LOCUS       NM_001084               2843 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
            (PLOD3), mRNA.
ACCESSION   NM_001084
VERSION     NM_001084.3  GI:34147645
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Wang,C., Luosujarvi,H., Heikkinen,J., Risteli,M., Uitto,L. and
            Myllyla,R.
  TITLE     The third activity for lysyl hydroxylase 3: galactosylation of
            hydroxylysyl residues in collagens in vitro
  JOURNAL   Matrix Biol. 21 (7), 559-566 (2002)
   PUBMED   12475640
  REMARK    GeneRIF: Manipulation of the gene for LH3 can be used to
            selectively alter glycosylation and hydroxylation reactions, and
            provides new tool to clarify functions of unique hydroxylysine
            linked carbohydrates in collagens and other proteins.
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Rautavuoma,K., Takaluoma,K., Passoja,K., Pirskanen,A., Kvist,A.P.,
            Kivirikko,K.I. and Myllyharju,J.
  TITLE     Characterization of three fragments that constitute the monomers of
            the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal
            fragment is not required for lysyl hydroxylase activity
  JOURNAL   J. Biol. Chem. 277 (25), 23084-23091 (2002)
   PUBMED   11956192
  REMARK    GeneRIF: Characterization of three fragments that constitute the
            monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa
            N-terminal fragment is not required for lysyl hydroxylase activity
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Heikkinen,J., Risteli,M., Wang,C., Latvala,J., Rossi,M.,
            Valtavaara,M. and Myllyla,R.
  TITLE     Lysyl hydroxylase 3 is a multifunctional protein possessing
            collagen glucosyltransferase activity
  JOURNAL   J. Biol. Chem. 275 (46), 36158-36163 (2000)
   PUBMED   10934207
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Passoja,K., Rautavuoma,K., Ala-Kokko,L., Kosonen,T. and
            Kivirikko,K.I.
  TITLE     Cloning and characterization of a third human lysyl hydroxylase
            isoform
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (18), 10482-10486 (1998)
   PUBMED   9724729
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Valtavaara,M., Szpirer,C., Szpirer,J. and Myllyla,R.
  TITLE     Primary structure, tissue distribution, and chromosomal
            localization of a novel isoform of lysyl hydroxylase (lysyl
            hydroxylase 3)
  JOURNAL   J. Biol. Chem. 273 (21), 12881-12886 (1998)
   PUBMED   9582318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC011674.2.
            On Aug 25, 2003 this sequence version replaced gi:21361165.
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2843
                     /gene="PLOD3"
                     /note="synonym: LH3"
                     /db_xref="GeneID:8985"
                     /db_xref="MIM:603066"
     CDS             314..2530
                     /gene="PLOD3"
                     /note="lysyl hydroxylase 3; procollagen-lysine,
                     2-oxoglutarate 5-dioxygenase 3v;
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence TAS] [pmid 9724729];
                     go_function: oxidoreductase activity [goid 0016491]
                     [evidence IEA];
                     go_function: procollagen-lysine 5-dioxygenase activity
                     [goid 0008475] [evidence TAS] [pmid 9724729];
                     go_function: oxidoreductase activity, acting on single
                     donors with incorporation of molecular oxygen,
                     incorporation of two atoms of oxygen [goid 0016702]
                     [evidence IEA];
                     go_process: protein modification [goid 0006464] [evidence
                     TAS] [pmid 9724729]"
                     /codon_start=1
                     /product="procollagen-lysine, 2-oxoglutarate 5-dioxygenase
                     3"
                     /protein_id="NP_001075.1"
                     /db_xref="GI:4505891"
                     /db_xref="GeneID:8985"
                     /db_xref="MIM:603066"
                     /translation="MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITV
                     ATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYAD
                     REDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTG
                     KRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRI
                     FQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPE
                     GGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHN
                     NEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLD
                     ADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQR
                     KRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSN
                     QHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDV
                     YWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWL
                     QLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHK
                     GLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP"
ORIGIN      
        1 gcttccacat gtgtcaagcg gctggctcag cccagagtcc ctgtctcccg cccgccggcc
       61 cgagccgccg cccctccccc gcctcccgtg cgcccgggac aatcctcgcc ttgtctgtgg
      121 cgccggcatc tggagctttc tgtagcctcc ggatacgcct ttttttcagg gcgtagcccc
      181 agccaagctg ctccccgcgg cggccgcaca gcagcccgag cgcccccttt ccggagctcc
      241 cctccggagc tgggatccag gcgcgtagcg gagatcccag gatcctgggt gctgtctggg
      301 cccgctcccc accatgacct cctcggggcc tggaccccgg ttcctgctgc tgctgccgct
      361 gctgctgccc cctgcggcct cagcctccga ccggccccgg ggccgagacc cggtcaaccc
      421 agagaagctg ctggtgatca ctgtggccac agctgaaacc gaggggtacc tgcgtttcct
      481 gcgctctgcg gagttcttca actacactgt gcggaccctg ggcctgggag aggagtggcg
      541 agggggtgat gtggctcgaa cagttggtgg aggacagaag gtccggtggt taaagaagga
      601 aatggagaaa tacgctgacc gggaggatat gatcatcatg tttgtggata gctacgacgt
      661 gattctggcc ggcagcccca cagagctgct gaagaagttc gtccagagtg gcagccgcct
      721 gctcttctct gcagagagct tctgctggcc cgagtggggg ctggcggagc agtaccctga
      781 ggtgggcacg gggaagcgct tcctcaattc tggtggattc atcggttttg ccaccaccat
      841 ccaccaaatc gtgcgccagt ggaagtacaa ggatgatgac gacgaccagc tgttctacac
      901 acggctctac ctggacccag gactgaggga gaaactcagc cttaatctgg atcataagtc
      961 tcggatcttt cagaacctca acggggcttt agatgaagtg gttttaaagt ttgatcggaa
     1021 ccgtgtgcgt atccggaacg tggcctacga cacgctcccc attgtggtcc atggaaacgg
     1081 tcccactaag ctgcagctca actacctggg aaactacgtc cccaatggct ggactcctga
     1141 gggaggctgt ggcttctgca accaggaccg gaggacactc ccgggggggc agcctccccc
     1201 ccgggtgttt ctggccgtgt ttgtggaaca gcctactccg tttctgcccc gcttcctgca
     1261 gcggctgcta ctcctggact atccccccga cagggtcacc cttttcctgc acaacaacga
     1321 ggtcttccat gaaccccaca tcgctgactc ctggccgcag ctccaggacc acttctcagc
     1381 tgtgaagctc gtggggccgg aggaggctct gagcccaggc gaggccaggg acatggccat
     1441 ggacctgtgt cggcaggacc ccgagtgtga gttctacttc agcctggacg ccgacgctgt
     1501 cctcaccaac ctgcagaccc tgcgtatcct cattgaggag aacaggaagg tgatcgcccc
     1561 catgctgtcc cgccacggca agctgtggtc caacttctgg ggcgccctga gccccgatga
     1621 gtactacgcc cgctccgagg actacgtgga gctggtgcag cggaagcgag tgggtgtgtg
     1681 gaatgtacca tacatctccc aggcctatgt gatccggggt gataccctgc ggatggagct
     1741 gccccagagg gatgtgttct cgggcagtga cacagacccg gacatggcct tctgtaagag
     1801 ctttcgagac aagggcatct tcctccatct gagcaatcag catgaatttg gccggctcct
     1861 ggccacttcc agatacgaca cggagcacct gcaccccgac ctctggcaga tcttcgacaa
     1921 ccccgtcgac tggaaggagc agtacatcca cgagaactac agccgggccc tggaagggga
     1981 aggaatcgtg gagcagccat gcccggacgt gtactggttc ccactgctgt cagaacaaat
     2041 gtgtgatgag ctggtggcag agatggagca ctacggccag tggtcaggcg gccggcatga
     2101 ggattcaagg ctggctggag gctacgagaa tgtgcccacc gtggacatcc acatgaagca
     2161 ggtggggtac gaggaccagt ggctgcagct gctgcggacg tatgtgggcc ccatgaccga
     2221 gagcctgttt cccggttacc acaccaaggc gcgggcggtg atgaactttg tggttcgcta
     2281 ccggccagac gagcagccgt ctctgcggcc acaccacgac tcatccacct tcaccctcaa
     2341 cgttgccctc aaccacaagg gcctggacta tgagggaggt ggctgccgct tcctgcgcta
     2401 cgactgtgtg atctcctccc cgaggaaggg ctgggcactc ctgcaccccg gccgcctcac
     2461 ccactaccac gaggggctgc caacgacctg gggcacacgc tacatcatgg tgtcctttgt
     2521 cgacccctga cactcaacca ctctgccaaa cctgccctgc cattgtgcct ttttaggggg
     2581 cctggccccc gtcctgggag ttgggggatg ggtctctctg tctccccact tcctgagttc
     2641 atgttccgcg tgcctgaact gaatatgtca ccttgctccc aagacacggc cctctcagga
     2701 agctcccgga gtccccgcct ctctcctccg cccacagggg ttcgtgggca cagggcttct
     2761 ggggactccc cgcgtgataa attattaatg ttccgcagtc tcactctgaa taaaggacag
     2821 tttgtaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_001259              11611 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens cyclin-dependent kinase 6 (CDK6), mRNA.
ACCESSION   NM_001259
VERSION     NM_001259.5  GI:45827787
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11611)
  AUTHORS   Klausen,P., Bjerregaard,M.D., Borregaard,N. and Cowland,J.B.
  TITLE     End-stage differentiation of neutrophil granulocytes in vivo is
            accompanied by up-regulation of p27kip1 and down-regulation of
            CDK2, CDK4, and CDK6
  JOURNAL   J. Leukoc. Biol. 75 (3), 569-578 (2004)
   PUBMED   14694185
  REMARK    GeneRIF: cyclin-dependent kinase (CDK)2, -4, and -6 were
            down-regulated from the myelocytes/metamyelocytes stages and onward
REFERENCE   2  (bases 1 to 11611)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   3  (bases 1 to 11611)
  AUTHORS   Chen,Q., Lin,J., Jinno,S. and Okayama,H.
  TITLE     Overexpression of Cdk6-cyclin D3 highly sensitizes cells to
            physical and chemical transformation
  JOURNAL   Oncogene 22 (7), 992-1001 (2003)
   PUBMED   12592386
  REMARK    GeneRIF: Overexpression of transfected human Cdk6 & mouse cyclin D3
            enhances susceptibility of BALB/c3T3 & C3H10T1/2 mouse fibroblast
            lines to UV radiation & 3-methylcholanthrene transformation.
REFERENCE   4  (bases 1 to 11611)
  AUTHORS   Morris,M., Hepburn,P. and Wynford-Thomas,D.
  TITLE     Sequential extension of proliferative lifespan in human fibroblasts
            induced by over-expression of CDK4 or 6 and loss of p53 function
  JOURNAL   Oncogene 21 (27), 4277-4288 (2002)
   PUBMED   12082615
  REMARK    GeneRIF: Sequential extension of proliferative lifespan in human
            fibroblasts is induced by over-expression of CDK4 or 6 and loss of
            p53 function.
REFERENCE   5  (bases 1 to 11611)
  AUTHORS   Brito-Babapulle,V., Gruszka-Westwood,A.M., Platt,G., Andersen,C.L.,
            Elnenaei,M.O., Matutes,E., Wotherspoon,A.C., Weston-Smith,S.G. and
            Catovsky,D.
  TITLE     Translocation t(2;7)(p12;q21-22) with dysregulation of the CDK6
            gene mapping to 7q21-22 in a non-Hodgkin's lymphoma with leukemia
  JOURNAL   Haematologica 87 (4), 357-362 (2002)
   PUBMED   11940479
  REMARK    GeneRIF: a patient with the dignosis of B-cell lymphoma with cdk6
            expression is dysregulated mapping to chromosome 7.
REFERENCE   6  (bases 1 to 11611)
  AUTHORS   Schulze-Gahmen,U. and Kim,S.H.
  TITLE     Structural basis for CDK6 activation by a virus-encoded cyclin
  JOURNAL   Nat. Struct. Biol. 9 (3), 177-181 (2002)
   PUBMED   11828325
  REMARK    GeneRIF: crystal structure of human CDK6--Vcyclin in an active
            state was determined to 3.1 A resolution to better understand the
            structural basis of CDK6 activation by viral cyclins
REFERENCE   7  (bases 1 to 11611)
  AUTHORS   Kaldis,P., Ojala,P.M., Tong,L., Makela,T.P. and Solomon,M.J.
  TITLE     CAK-independent activation of CDK6 by a viral cyclin
  JOURNAL   Mol. Biol. Cell 12 (12), 3987-3999 (2001)
   PUBMED   11739795
  REMARK    GeneRIF: KSHV-cyclin can activate CDK6 independent of
            phosphorylation by CAK in vitro
REFERENCE   8  (bases 1 to 11611)
  AUTHORS   Ezhevsky,S.A., Ho,A., Becker-Hapak,M., Davis,P.K. and Dowdy,S.F.
  TITLE     Differential regulation of retinoblastoma tumor suppressor protein
            by G(1) cyclin-dependent kinase complexes in vivo
  JOURNAL   Mol. Cell. Biol. 21 (14), 4773-4784 (2001)
   PUBMED   11416152
REFERENCE   9  (bases 1 to 11611)
  AUTHORS   Kwon,T.K. and Park,J.W.
  TITLE     Low levels of cyclin D and nonfunctional Rb protein affect cdk6
            association with cyclin-dependent kinase inhibitor p27(Kip1)
  JOURNAL   Biochem. Biophys. Res. Commun. 284 (1), 106-111 (2001)
   PUBMED   11374878
REFERENCE   10 (bases 1 to 11611)
  AUTHORS   Harbour,J.W., Luo,R.X., Dei Santi,A., Postigo,A.A. and Dean,D.C.
  TITLE     Cdk phosphorylation triggers sequential intramolecular interactions
            that progressively block Rb functions as cells move through G1
  JOURNAL   Cell 98 (6), 859-869 (1999)
   PUBMED   10499802
REFERENCE   11 (bases 1 to 11611)
  AUTHORS   Brotherton,D.H., Dhanaraj,V., Wick,S., Brizuela,L., Domaille,P.J.,
            Volyanik,E., Xu,X., Parisini,E., Smith,B.O., Archer,S.J.,
            Serrano,M., Brenner,S.L., Blundell,T.L. and Laue,E.D.
  TITLE     Crystal structure of the complex of the cyclin D-dependent kinase
            Cdk6 bound to the cell-cycle inhibitor p19INK4d
  JOURNAL   Nature 395 (6699), 244-250 (1998)
   PUBMED   9751051
REFERENCE   12 (bases 1 to 11611)
  AUTHORS   Russo,A.A., Tong,L., Lee,J.O., Jeffrey,P.D. and Pavletich,N.P.
  TITLE     Structural basis for inhibition of the cyclin-dependent kinase Cdk6
            by the tumour suppressor p16INK4a
  JOURNAL   Nature 395 (6699), 237-243 (1998)
   PUBMED   9751050
REFERENCE   13 (bases 1 to 11611)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   14 (bases 1 to 11611)
  AUTHORS   Bullrich,F., MacLachlan,T.K., Sang,N., Druck,T., Veronese,M.L.,
            Allen,S.L., Chiorazzi,N., Koff,A., Heubner,K., Croce,C.M. et al.
  TITLE     Chromosomal mapping of members of the cdc2 family of protein
            kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor,
            p27Kip1, to regions involved in human cancer
  JOURNAL   Cancer Res. 55 (6), 1199-1205 (1995)
   PUBMED   7882308
REFERENCE   15 (bases 1 to 11611)
  AUTHORS   Meyerson,M. and Harlow,E.
  TITLE     Identification of G1 kinase activity for cdk6, a novel cyclin D
            partner
  JOURNAL   Mol. Cell. Biol. 14 (3), 2077-2086 (1994)
   PUBMED   8114739
REFERENCE   16 (bases 1 to 11611)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J. 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052264.1, BQ048881.1,
            BM542736.1, BQ213893.1, BG166127.1, BM542629.1, AI400582.1,
            AI023175.1, BM978533.1, BM905472.1, AV726767.1, BU159055.1,
            BM542578.1, BE893003.1, AI935072.1, BQ231384.1, AK055922.1,
            AA312213.1, BC027989.1 and AI367890.1.
            On Mar 30, 2004 this sequence version replaced gi:42741665.
            
            Summary: The protein encoded by this gene is a member of the
            cyclin-dependent protein kinase (CDK) family. CDK family members
            are highly similar to the gene products of Saccharomyces cerevisiae
            cdc28, and Schizosaccharomyces pombe cdc2, and are known to be
            important regulators of cell cycle progression. This kinase is a
            catalytic subunit of the protein kinase complex that is important
            for cell cycle G1 phase progression and G1/S transition. The
            activity of this kinase first appears in mid-G1 phase, which is
            controlled by the regulatory subunits including D-type cyclins and
            members of INK4 family of CDK inhibitors. This kinase, as well as
            CDK4, has been shown to phosphorylate, and thus regulate the
            activity of, tumor suppressor protein Rb.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..11611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21-q22"
     gene            1..11611
                     /gene="CDK6"
                     /note="synonyms: PLSTIRE, MGC59692"
                     /db_xref="GeneID:1021"
                     /db_xref="MIM:603368"
     CDS             394..1374
                     /gene="CDK6"
                     /EC_number="2.7.1.-"
                     /note="cell division protein kinase 6;
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence IEA];
                     go_process: cytokinesis [goid 0000910] [evidence IEA];
                     go_process: regulation of cell cycle [goid 0000074]
                     [evidence TAS] [pmid 8114739];
                     go_process: G1 phase of mitotic cell cycle [goid 0000080]
                     [evidence TAS] [pmid 8114739];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence IEA]"
                     /codon_start=1
                     /product="cyclin-dependent kinase 6"
                     /protein_id="NP_001250.1"
                     /db_xref="GI:4502741"
                     /db_xref="GeneID:1021"
                     /db_xref="MIM:603368"
                     /translation="MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR
                     VRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD
                     QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK
                     LADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL
                     FRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL
                     LLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA"
     polyA_signal    11455..11460
                     /gene="CDK6"
     polyA_signal    11464..11469
                     /gene="CDK6"
     polyA_site      11488
                     /gene="CDK6"
                     /evidence=experimental
     polyA_signal    11570..11575
                     /gene="CDK6"
     polyA_site      11593
                     /gene="CDK6"
                     /evidence=experimental
ORIGIN      
        1 ggcttcagcc ctgcagggaa agaaaagtgc aatgattctg gactgagacg cgcttgggca
       61 gaggctatgt aatcgtgtct gtgttgagga cttcgcttcg aggagggaag aggagggatc
      121 ggctcgctcc tccggcggcg gcggcggcgg cgactctgca ggcggagttt cgcggcggcg
      181 gcaccagggt tacgccagcc ccgcggggag gtctctccat ccagcttctg cagcggcgaa
      241 agccccagcg cccgagcgcc tgagccggcg gggagcaagt aaagctagac cgatctccgg
      301 ggagccccgg agtaggcgag cggcggccgc cagctagttg agcgcacccc ccgcccgccc
      361 cagcggcgcc gcggcgggcg gcgtccaggc ggcatggaga aggacggcct gtgccgcgct
      421 gaccagcagt acgaatgcgt ggcggagatc ggggagggcg cctatgggaa ggtgttcaag
      481 gcccgcgact tgaagaacgg aggccgtttc gtggcgttga agcgcgtgcg ggtgcagacc
      541 ggcgaggagg gcatgccgct ctccaccatc cgcgaggtgg cggtgctgag gcacctggag
      601 accttcgagc accccaacgt ggtcaggttg tttgatgtgt gcacagtgtc acgaacagac
      661 agagaaacca aactaacttt agtgtttgaa catgtcgatc aagacttgac cacttacttg
      721 gataaagttc cagagcctgg agtgcccact gaaaccataa aggatatgat gtttcagctt
      781 ctccgaggtc tggactttct tcattcacac cgagtagtgc atcgcgatct aaaaccacag
      841 aacattctgg tgaccagcag cggacaaata aaactcgctg acttcggcct tgcccgcatc
      901 tatagtttcc agatggctct aacctcagtg gtcgtcacgc tgtggtacag agcacccgaa
      961 gtcttgctcc agtccagcta cgccaccccc gtggatctct ggagtgttgg ctgcatattt
     1021 gcagaaatgt ttcgtagaaa gcctcttttt cgtggaagtt cagatgttga tcaactagga
     1081 aaaatcttgg acgtgattgg actcccagga gaagaagact ggcctagaga tgttgccctt
     1141 cccaggcagg cttttcattc aaaatctgcc caaccaattg agaagtttgt aacagatatc
     1201 gatgaactag gcaaagacct acttctgaag tgtttgacat ttaacccagc caaaagaata
     1261 tctgcctaca gtgccctgtc tcacccatac ttccaggacc tggaaaggtg caaagaaaac
     1321 ctggattccc acctgccgcc cagccagaac acctcggagc tgaatacagc ctgaggcctc
     1381 agcagccgcc ttaagctgat cctgcggaga acacccttgg tggcttatgg gtccccctca
     1441 gcaagcccta cagagctgtg gaggattgct atctggaggc cttccagctg ctgtcttctg
     1501 gacaggctct gcttctccaa ggaaaccgcc tagtttactg ttttgaaatc aatgcaagag
     1561 tgattgcagc tttatgttca tttgtttgtt tgtttgtctg tttgtttcaa gaacctggaa
     1621 aaattccaga agaagagaag ctgctgacca attgtgctgc catttgattt ttctaacctt
     1681 gaatgctgcc agtgtggagt gggtaatcca ggcacagctg agttatgatg taatctctct
     1741 gcagctgccg ggcctgattt ggtacttttg agtgtgtgtg tgcatgtgtg tgtgtgtgtg
     1801 tgtgtgtgtg tgtgtgtatg tgagagattc tgtgatcttt taaagtgtta ctttttgtaa
     1861 acgacaagaa taattcaatt ttaaagactc aaggtggtca gtaaataaca ggcatttgtt
     1921 cactgaaggt gattcaccaa aatagtcttc tcaaattaga aagttaaccc catgtcctca
     1981 gcatttcttt tctggccaaa agcagtaaat ttgctagcag taaaagatga agttttatac
     2041 acacagcaaa aaggagaaaa aattctagta tattttaaga gatgtgcatg cattctattt
     2101 agtcttcaga atgctgaatt tacttgttgt aagtctattt taaccttctg tatgacatca
     2161 tgctttatca tttcttttgg aaaatagcct gtaagctttt tattacttgc tataggttta
     2221 gggagtgtac ctcagataga ttttaaaaaa aagaatagaa agcctttatt tcctggtttg
     2281 aaattccttt cttccctttt tttgttgttg ttattgttgt ttgttgttgt tattttgttt
     2341 ttgtttttag gaatttgtca gaaactcttt cctgttttgg tttggagagt agttctctct
     2401 aactagagac aggagtggcc ttgaaatttt cctcatctat tacactgtac tttctgccac
     2461 acactgcctt gttggcaaag tatccatctt gtctatctcc cggcacttct gaaatatatt
     2521 gctaccattg tataactaat aacagattgc ttaagctgtt cccatgcacc acctgtttgc
     2581 ttgctttcaa tgaacctttc ataaattcgc agtctcagct tatggtttat ggcctcgatt
     2641 ctgcaaacct aacagggtca catatgttct ctaatgcagt ccttctacct ggtgtttact
     2701 tttgctaccc aaataatgag taggatcttg ttttcgtata cccccaccac tcccattgct
     2761 accaactgtc accttgtgca ctcctttttt atagaagata ttttcagtgt ctttacctga
     2821 gggtatgtct ttagctatgt tttagggcca tacatttact ctatcaaatg atcttttctc
     2881 catcccccag gctgtgctta tttctagtgc cttgtgctca ctcctgctct ctacagagcc
     2941 agcctggcct gggcattgta aacagctttt cctttttctc ttactgtttt ctctacagtc
     3001 ctttatattt cataccatct ctgccttata agtggtttag tgctcagttg gctctagtaa
     3061 ccagaggaca cagaaagtat cttttggaaa gtttagccac ctgtgctttc tgactcagag
     3121 tgcatgcaac agttagatca tgcaacagtt agattatgtt tagggttagg attttcaaag
     3181 aatggaggtt gctgcactca gaaaataatt cagatcatgt ttatgcatta ttaagttgta
     3241 ctgaattctt tgcagcttaa tgtgatatat gactatcttg aacaagagaa aaaactagga
     3301 gatgtttctc ctgaagagct tttggggttg ggaactattc ttttttaatt gctgtactac
     3361 ttaacattgt tctaattcag tagcttgagg aacaggaaca ttgttttcta gagcaagata
     3421 ataaaggaga tgggccatac aaatgttttc tactttcgtt gtgacaacat tgattaggtg
     3481 ttgtcagtac tataaatgct tgagatataa tgaatccaca gcattcaagg tcaggtctac
     3541 tcaaagtctc acatggaaaa gtgagttctg cctttccttt gatcgagggt caaaatacaa
     3601 agacattttt gctagggcct acaaattgaa tttaaaaact cactgcactg attcatctga
     3661 gctttttggt tagtattcat ggctagagtg aacatagctt tagtttttgc tgttgtaaaa
     3721 gtgttttcat aagttcactc aagaaaaatg cagctgttct gaactggaat ttttcagcat
     3781 tctttagaat tttaaatgag tagagagctc aacttttatt cctagcatct gcttttgact
     3841 catttctagg cagtgcttat gaagaaaaat taaagcacaa acattctggc attcaatcgt
     3901 tggcagatta tcttctgatg acacagaatg aaagggcatc tcagcctctc tgaactttgt
     3961 aaaaatctgt ccccagttct tccatcggtg tagttgttgc atttgagtga atactctctt
     4021 gatttatgta ttttatgtcc agattcgcca tttctgaaat ccagatccaa cacaagcagt
     4081 cttgccgtta gggcattttg aagcagatag tagagtaaga acttagtgac tacagcttat
     4141 tcttctgtaa catatggttt caaacatctt tgccaaaagc taagcagtgg tgaactgaaa
     4201 agggcatatt gccccaaggt tacactgaag cagctcatag caagttaaaa tattgtgaca
     4261 gatttgaaat catgtttgaa tttcatagta ggaccagtac aagaatgtcc ctgctagttt
     4321 ctgtttgatg tttggttctg gcggctcagg cattttggga actgttgcac agggtgcagt
     4381 caaaacaacc tacatataaa aattacataa aagaaccttg tccatttagc tttcataaga
     4441 aatcccatgg caaagagtaa taaaaaggac ctaatcttaa aaatacaatt tctaagcact
     4501 tgtaagaacc cagtgggttg gagcctccca ctttgtccct cctttgaagt ggatgggaac
     4561 tcaaggtgca aagaacctgt tttggaagaa agcttggggc catttcagcc ccctgtattc
     4621 tcatgatttt ctctcaggaa gcacacactg tgaatggcag acttttcatt tagccccagg
     4681 tgacttacta aaaatagttg aaaattattc acctaagaat agaatctcag cattgtgtta
     4741 aataaaaatg aaagctttag aaggcatgag atgttcctat cttaaataaa gcatgtttct
     4801 tttctataga gaaatgtata gtttgactct ccagaatgta ctatccatct tgatgagaaa
     4861 actcttaaat agtaccaaac attttgaact ttaaattatg tatttaaagt gagtgtttaa
     4921 gaaactgtag ctgcttcttt tacaagtggt gcctattaaa gtcagtaatg gccattattg
     4981 ttccattgtg gaaattaaat tatgtaagct tcctaatatc ataaacatat taaaattctt
     5041 ctaaaatatt gcttttcttt taagtgacaa tttgactatt cttatgataa gcacatgaga
     5101 gtgtcttaca ttttccaaaa gcaggcttta attgcatagt tgagtctagg aaaaaataat
     5161 gttaaaagtg aatatgccac cataattact taattatgtt agtatagaaa ctacagaata
     5221 tttaccctgg aaagaaaata ttggaatgtt attataaact cttagatatt tatataattc
     5281 aaaagaatgc atgtttcaca ttgtgacaga taaagatgta tgatttctaa ggctttaaaa
     5341 attattcata aaacagtggg caatagataa aggaaattct ggagaaaatg aaggtattta
     5401 aagggtagtt tcaaagctat atatattttg aaggatatat tctttatgaa caaatatatt
     5461 gtaaaaattt atactaaggt catctggtaa ctgtgggatt aatatggtcg aaaacaaatg
     5521 ttatggagaa gctgtcccaa gcaaactaaa ttacctgtac ttttttccca tttcaaggga
     5581 agaggcaacc acatgaagca atacttctta cacatgccta agaacgttca ttgaaaaaat
     5641 aaatttttaa aaggcatgtg tttcctatgc caccaatact tttgaaaaat tgtgaacctt
     5701 acccaaaacc atttatcatg tccattaagt atatttgggt atataattag gaagatattt
     5761 acatgttcca tctccacagt ggaaaaactt attgaggcta ccaaagtgtg ccaagaaatg
     5821 taagtcctta gagtaattag aaatgctgtt ttcctcaaaa gcatgagaaa ctagcatttt
     5881 catttcttat ttactccctt tctatatcaa tgcaattcac aacccaattt taatacatcc
     5941 ctatatctca agcatttcta tcttgtactt tttcagaaaa taaaccaaaa ataatccttt
     6001 ggtctctcta tcttctgacc tttgtaagca acagaaatgt aaaaacagaa ggggtccaat
     6061 ttttacacgt ttttttctca agtagccttt ctggggattt ttattttctt aatgaagtgc
     6121 caatcagctt ttcaaaatgt tttctatttc tcagcatttc caggaagtga taacgtttag
     6181 ctaaatgagt agaagtggac ttccttcaac atattgttac cttgtctagc cttaggaaga
     6241 aaacaagagc cacctgaaaa taaatacagg ctcttttcga gcatctgctg aaatactgtt
     6301 acagcaattt gaagttgatg tggtaggaaa ggaaggtgac ttttcttgca aaagtctttc
     6361 taaacattca cactgtccta agagatgagc tttcttgttt tattccggta tattccacaa
     6421 ggtggcactt ttagagaaaa acaaatctga tgaagactaa agaggtactt ctaaaagaga
     6481 tttcattcta actttatttt tctgcgcata tttaactctt tcctagcact tgttttttgg
     6541 gatgattaat agtctctata atgttctgta acttcaatat tttacttgtt acctaggttc
     6601 tgaacaattg tctgcaaata aattgttctt aaggatggat aatacaccca ttttgatcat
     6661 ttaagtaaag aaagcctagt cattcattca gtcaagaaaa aatttttgaa gtacccagtt
     6721 accttacttt tctagattaa aacaggctta gttactaaaa aggcagtcct catctgtgaa
     6781 caggatagtt tcgttagaag tataaaactc ctttagtggc cccagttaaa acacacatac
     6841 cctctctgct gctttcaaat tccctagcat ggtggccttt caacattgat taaattttaa
     6901 aatcctaatt taaagatcag gtgagcaaaa tgagtagcac atcagtaatt cagtagacaa
     6961 aacttttgtc tgaaaaattg ctgtattgaa acagagccct aaaataccaa aagaccaggt
     7021 aattttaaca tttgtggaat cacaaatgta aattcataag aagctctaat taaaaaaaaa
     7081 aagtctgaag tatatgagca taacaactta ggagtgtgtc tacatactta acttttgaag
     7141 ttttttggca actttatata ctttttttaa atttacaagt ctacttaaag acttcttata
     7201 ccccaaatga ttaagttaat tttagaggtc acctttctca cagcagtgtc acttgaaatt
     7261 tagtagggaa ggatattgca gtatttttca gtttccttag cacagcacca cagaaagcag
     7321 cttattcctt ttgagtggca gacactcgac ggtgcctgcc caactttcct cctgagtggc
     7381 aagcagatga gtctcagtaa ttcatactga accaaaatgc cacatacact aggggcagtc
     7441 agaaactggc tgagaaatcc cccgcctcat tcgcccctct gctcccagga actagagtcc
     7501 agttaaagcc cctatgcgaa aggccgaatt ccaccccagg gtttgttata acagtggcca
     7561 gtctgaaccc catttgctcg tgctcaaaac ttgattccca cttgaaagcc ttccgggcgc
     7621 gctgcctcgt tgccccgccc ctttggcagg agagaggcag tgggcgaggc cgggctgggg
     7681 ccccgcctcc cactcacctg ccggtgcctg aaattatgtg cggccccgcg ggctgctttc
     7741 cgaggtcaga gtgccctgct gctgtctcag aggcatctgt tctgcaaatc ttaggaagaa
     7801 aaatgtccct agtagcaaac gggtgtcttc tgtgcataaa taagtacaac acaattctcc
     7861 gaaagttcgg gtaaaaagag atgcggtagc agctgccctg tgtgaagctg tctaccccgc
     7921 atctctcagg cgctaagctc agtttttgtt tttgtttttg tttttttaaa gaaaagatgt
     7981 ataattgcag gaattttttt ttattttttt attttccatc attctatata tgtgatggtg
     8041 aaagatatgc ctggaaaagt tttgttttga aaagtttatt ttctgcttcg tcttcagttg
     8101 gcaaaagctc tcaattcttt agcttccagt ttcttttctc tctttttctt tgttaggtaa
     8161 ttaaaggtat gtaaacaaat tatctcatgt agcaggggat tttcatgttg agaggaatct
     8221 tccgtgtgag ttgtttggtc acacaaataa ccctttctca attttaggag tttggattgt
     8281 caaatgtagg tttttctcaa agggggcata taactacata ttgactgcca agaactatga
     8341 ctgtagcact aatcagcaca catagagcca cacaattatt taatttctaa ctctctgtgg
     8401 tccctagaaa aattccgttg atgtgcttag gttaaagttc tgaagatacc cgttgtaccc
     8461 ttacttgaaa gtttctaatc ttaagtttta tgaaatgcaa taatatgtat cagctagcaa
     8521 tatttctgtg atcaccaaca actctcagtt tgatcttaaa gtctgaataa taaaacaaat
     8581 cccagcagta atacatttct taaacctcac agtgcatgat atatcttttc attctgatcc
     8641 tgtgtttgca aaaatataca catgtatatc atagttcctc actttttatt catttgtttt
     8701 cctattacct gtagtaaata tattagttag tacatggaat ttatagcatc agctaccccc
     8761 aggaacagca cctgacaggc gggggatttt ttttcaagtt gttctacatt tgcataaatt
     8821 atttctatta ttattcatgt atgttattta tttctgaatc acactagtcc tgtgaaagta
     8881 caactgaagg cagaaagtgt taggattttg catctaatgt tcattatcat ggtattgatg
     8941 gacctaagaa aataaaaatt agactaagcc cccaaataag ctgcatgcat ttgtaacatg
     9001 attagtagat ttgaatatat agatgtagta ttttgggtat ctaggtgttt tatcattatg
     9061 taaaggaatt aaagtaaagg actttgtagt tgtttttatt aaatatgcat atagtagagt
     9121 gcaaaaatat agcaaaaata aaaactaaag gtagaaaagc attttagata tgccttaatt
     9181 tagaaactgt gccaggtggc cctcggaata gatgccaggc agagaccagt gcctgggtgg
     9241 tgcctcctct tgtctgccct catgaagaag cttccctcac gtgatgtagt gccctcgtag
     9301 gtgtcatgtg gagtagtggg aacaggcagt actgttgaga ggagagcagt gtgagagttt
     9361 ttctgtagaa gcagaactgt cagcttgtgc cttgaggctt ccagaacgtg tcagatggag
     9421 aagtccaagt ttccatgctt caggcaactt agctgtgtac agaagcaatc cagtgtggta
     9481 ataaaaagca aggattgcct gtataattta ttataaaata aaagggattt taacaaccaa
     9541 caattcccaa cacctcaaaa gcttgttgca ttttttggta tttgaggttt ttatctgaag
     9601 gttaaagggc aagtgtttgg tatagaagag cagtatgtgt taagaaaaga aaaatattgg
     9661 ttcacgtaga gtgcaaatta gaactagaaa gttttatacg attatcattt tgagatgtgt
     9721 taaagtaggt tttcactgta aaatgtatta gtgtttctgc attgccatag ggcctggtta
     9781 aaactttctc ttaggtttca ggaagactgt cacatacagt aagctttttt ccttctgact
     9841 tataatagaa aatgttttga aagtaaaaaa aaaaaatcta atttggaaat ttgacttgtt
     9901 agtttctgtg tttgaaatca tggttctaga aatgtagaaa ttgtgtatat cagatactca
     9961 tctaggctgt gtgaaccagc ccaagatgac caacatcccc acacctctac atctctgtcc
    10021 cctgtatctc ttcctttcta ccactaaagt gttccctgct accatcctgg cttgtccaca
    10081 tggtgctctc catcttcctc cacatcatgg accacaggtg tgcctgtcta ggcctggcca
    10141 ccactcccaa cttgacctag ccacattcat ctagagatgg ttcctgatgc tgggcacaga
    10201 ctgtgctcat ggcacccatt agaaatgcct ctagcatctt tgtatgcatc ttgattttta
    10261 aaccaagtca ttgtacagag cattcagttt tggctgtggt accaagagaa aaactaatca
    10321 agaatataaa ccacattcca ggctgctgtt ttctctccat ctacaggcca cacttttact
    10381 gtatttcttc atacttgaaa ttcattctgc tattttcata tcagggtaca gacttataag
    10441 ggtgcatgtt ccttaaaggt gcataattat tcttattccg tttgcttata ttgctacaga
    10501 atgctctgtt ttggtgcttt gagttctgca gacccaagaa gcagtgtgga aattcactgc
    10561 ctgggacaca gtcttataag aatgttggca ggtgactttg tatcagatgt tgcttctctt
    10621 ttctctgtac acagattgag agttaccaca gtggcctgtc gggtccaccc tgtgggtgca
    10681 gcacagctct ctgaaagcaa gaaccttcct acctattcta acgtttttgc cctctaagaa
    10741 aaatggcctc aggtatggta tagacatagc aagaggggaa gggctgtctc actctagcaa
    10801 ccatccctcc attacacaca gaaagccctc ttgaagcaaa agaagaagaa agaaagaaag
    10861 cttatctcta aggctactgt cttcagaatg ctctgagctg aatgctcttg ctcctttccc
    10921 aagaggcaga tgaaaatata gccagtttat ctataccctt cctatctgag gaggagaata
    10981 gaaaagtagg gtaaatatgt aacgtaaaat atgtcattca aggaccacca aaactttaag
    11041 taccctatca ttaaaaatct ggttttaaaa gtagctcaag taagggatgc tttgtgaccc
    11101 agggtttctg aagtcagata gccattctta cctgcccctt actctgactt attgggaaag
    11161 ggagaactgc agtggtgttt ctgttgcagt ggcaaaggta acatgtcaga aaattcagag
    11221 ggttgcatac caataatcct ttggaaactg gatgtcttac tgggtgctag aatgaaaatg
    11281 taggtattta ttgtcagatg atgaagttca ttgttttttt caaaattggt gttgaaatat
    11341 cactgtccaa tgtgttcact tatgtgaaag ctaaattgaa tgaggcaaaa agagcaaata
    11401 gtttgtatat ttgtaatacc ttttgtattt cttacaataa aaatattggt agcaaataaa
    11461 aataataaaa acaataactt taaactgctt tctggagatg aattactctc ctggctattt
    11521 tcttttttac tttaatgtaa aatgagtata actgtagtga gtaaaattca ttaaattcca
    11581 agttttagca gaaaaaaaaa aaaaaaaaaa a
//

LOCUS       NM_001331               6232 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens catenin (cadherin-associated protein), delta 1
            (CTNND1), mRNA.
ACCESSION   NM_001331
VERSION     NM_001331.1  GI:10835009
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6232)
  AUTHORS   Krakstad,B.F., Ardawatia,V.V. and Aragay,A.M.
  TITLE     A role for Galpha12/Galpha13 in p120ctn regulation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (28), 10314-10319 (2004)
   PUBMED   15240885
  REMARK    GeneRIF: Galpha12-p120ctn interaction acts as a molecular switch,
            which regulates cadherin-mediated cell-cell adhesion.
REFERENCE   2  (bases 1 to 6232)
  AUTHORS   Shibata,T., Kokubu,A., Sekine,S., Kanai,Y. and Hirohashi,S.
  TITLE     Cytoplasmic p120ctn regulates the invasive phenotypes of
            E-cadherin-deficient breast cancer
  JOURNAL   Am. J. Pathol. 164 (6), 2269-2278 (2004)
   PUBMED   15161659
  REMARK    GeneRIF: Cytoplasmic p120ctn may contribute to the invasive
            phenotype of E-cadherin-deficient breast cancer cells
REFERENCE   3  (bases 1 to 6232)
  AUTHORS   Kondapalli,J., Flozak,A.S. and Albuquerque,M.L.
  TITLE     Laminar shear stress differentially modulates gene expression of
            p120 catenin, Kaiso transcription factor, and vascular endothelial
            cadherin in human coronary artery endothelial cells
  JOURNAL   J. Biol. Chem. 279 (12), 11417-11424 (2004)
   PUBMED   14699141
  REMARK    GeneRIF: differential expression of p120(ctn) and Kaiso mRNA was
            observed in human coronary artery endothelial cells depending on
            how laminar shear stress was applied in relation to the wounding
            process
REFERENCE   4  (bases 1 to 6232)
  AUTHORS   Franz,C.M. and Ridley,A.J.
  TITLE     p120 catenin associates with microtubules: inverse relationship
            between microtubule binding and Rho GTPase regulation
  JOURNAL   J. Biol. Chem. 279 (8), 6588-6594 (2004)
   PUBMED   14660598
  REMARK    GeneRIF: binding of p120ctn to microtubules is inversely related to
            its ability to regulate Rho GTPases
REFERENCE   5  (bases 1 to 6232)
  AUTHORS   Xiao,K., Allison,D.F., Buckley,K.M., Kottke,M.D., Vincent,P.A.,
            Faundez,V. and Kowalczyk,A.P.
  TITLE     Cellular levels of p120 catenin function as a set point for
            cadherin expression levels in microvascular endothelial cells
  JOURNAL   J. Cell Biol. 163 (3), 535-545 (2003)
   PUBMED   14610056
  REMARK    GeneRIF: Cellular levels of p120ctn function as a set point
            mechanism that regulates cadherin expression levels; a major
            function of p120ctn is to control cadherin internalization and
            degradation.
REFERENCE   6  (bases 1 to 6232)
  AUTHORS   Davis,M.A., Ireton,R.C. and Reynolds,A.B.
  TITLE     A core function for p120-catenin in cadherin turnover
  JOURNAL   J. Cell Biol. 163 (3), 525-534 (2003)
   PUBMED   14610055
  REMARK    GeneRIF: The data reveal a core function of p120 in cadherin
            complexes, and strongly predict a dose-dependent loss of E-cadherin
            in tumors that partially or completely down-regulate p120.
REFERENCE   7  (bases 1 to 6232)
  AUTHORS   Konstantoulaki,M., Kouklis,P. and Malik,A.B.
  TITLE     Protein kinase C modifications of VE-cadherin, p120, and
            beta-catenin contribute to endothelial barrier dysregulation
            induced by thrombin
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2), L434-L442 (2003)
   PUBMED   12740216
  REMARK    GeneRIF: study links posttranslational modifications of VEC,
            beta-catenin, and p120 to the mechanism of thrombin-induced
            increase in endothelial permeability
REFERENCE   8  (bases 1 to 6232)
  AUTHORS   Mayerle,J., Friess,H., Buchler,M.W., Schnekenburger,J., Weiss,F.U.,
            Zimmer,K.P., Domschke,W. and Lerch,M.M.
  TITLE     Up-regulation, nuclear import, and tumor growth stimulation of the
            adhesion protein p120 in pancreatic cancer
  JOURNAL   Gastroenterology 124 (4), 949-960 (2003)
   PUBMED   12671892
  REMARK    GeneRIF: Both p120(ctn)-defective tumor cell contacts and
            p120(ctn)-mediated growth signals appear to contribute to the
            aggressive spread of pancreatic cancer.
REFERENCE   9  (bases 1 to 6232)
  AUTHORS   Thoreson,M.A. and Reynolds,A.B.
  TITLE     Altered expression of the catenin p120 in human cancer:
            implications for tumor progression
  JOURNAL   Differentiation 70 (9-10), 583-589 (2002)
   PUBMED   12492499
  REMARK    GeneRIF: roles of p120 as a tumor suppressor or metastasis promoter
            are discussed (review)
REFERENCE   10 (bases 1 to 6232)
  AUTHORS   Ireton,R.C., Davis,M.A., van Hengel,J., Mariner,D.J., Barnes,K.,
            Thoreson,M.A., Anastasiadis,P.Z., Matrisian,L., Bundy,L.M.,
            Sealy,L., Gilbert,B., van Roy,F. and Reynolds,A.B.
  TITLE     A novel role for p120 catenin in E-cadherin function
  JOURNAL   J. Cell Biol. 159 (3), 465-476 (2002)
   PUBMED   12427869
  REMARK    GeneRIF: These data reveal a cooperative interaction between p120
            catenin and E-cadherin and a novel role for p120 that is likely
            indispensable in normal cells.
REFERENCE   11 (bases 1 to 6232)
  AUTHORS   Burger,M.J., Tebay,M.A., Keith,P.A., Samaratunga,H.M., Clements,J.,
            Lavin,M.F. and Gardiner,R.A.
  TITLE     Expression analysis of delta-catenin and prostate-specific membrane
            antigen: their potential as diagnostic markers for prostate cancer
  JOURNAL   Int. J. Cancer 100 (2), 228-237 (2002)
   PUBMED   12115574
  REMARK    GeneRIF: Overexpression of delta catenin is associated with
            prostatic adenocarcinoma
REFERENCE   12 (bases 1 to 6232)
  AUTHORS   Ferber,A., Yaen,C., Sarmiento,E. and Martinez,J.
  TITLE     An octapeptide in the juxtamembrane domain of VE-cadherin is
            important for p120ctn binding and cell proliferation
  JOURNAL   Exp. Cell Res. 274 (1), 35-44 (2002)
   PUBMED   11855855
  REMARK    GeneRIF: The interaction of VE-cadherin with p120 catenin plays an
            important role in cellular growth, suggesting that the binding of
            p120 catenin to cadherins may regulate cell proliferation.
REFERENCE   13 (bases 1 to 6232)
  AUTHORS   Keirsebilck,A., Bonne,S., Staes,K., van Hengel,J., Nollet,F.,
            Reynolds,A. and van Roy,F.
  TITLE     Molecular cloning of the human p120ctn catenin gene (CTNND1):
            expression of multiple alternatively spliced isoforms
  JOURNAL   Genomics 50 (2), 129-146 (1998)
   PUBMED   9653641
REFERENCE   14 (bases 1 to 6232)
  AUTHORS   Reynolds,A.B., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Shapiro,D.N., Wu,J. and Daniel,J.M.
  TITLE     The gene encoding p120cas, a novel catenin, localizes on human
            chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)
  JOURNAL   Genomics 31 (1), 127-129 (1996)
   PUBMED   8808291
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF062317.1.
FEATURES             Location/Qualifiers
     source          1..6232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q11"
     gene            1..6232
                     /gene="CTNND1"
                     /note="synonyms: CAS, CTNND, P120CAS, P120CTN, KIAA0384"
                     /db_xref="GeneID:1500"
                     /db_xref="MIM:601045"
     CDS             537..3362
                     /gene="CTNND1"
                     /note="go_component: nucleus [goid 0005634] [evidence NAS]
                     [pmid 9653641];
                     go_component: cytoskeleton [goid 0005856] [evidence IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: structural molecule activity [goid 0005198]
                     [evidence IEA];
                     go_process: cell-cell adhesion [goid 0016337] [evidence
                     NAS]"
                     /codon_start=1
                     /product="catenin (cadherin-associated protein), delta 1"
                     /protein_id="NP_001322.1"
                     /db_xref="GI:10835010"
                     /db_xref="GeneID:1500"
                     /db_xref="MIM:601045"
                     /translation="MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERV
                     RVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRM
                     QEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGP
                     DGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYE
                     DGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFH
                     PEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQY
                     YWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQH
                     LCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNC
                     DGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGW
                     EREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEI
                     GQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKG
                     KGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAI
                     QNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKEL
                     IGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEK
                     LVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSS
                     HSYDDSTLPLIDRNQKSDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQ
                     ESLEEELDVLVLDDEGGQVSYPSMQKI"
     polyA_signal    5480..5485
                     /gene="CTNND1"
                     /note="major poly-A signal"
     polyA_site      5499
                     /gene="CTNND1"
                     /note="major poly-A site"
     polyA_signal    6210..6215
                     /gene="CTNND1"
                     /note="minor poly-A signal"
ORIGIN      
        1 ctgccagatc agtttgtcac cacccaggct cccttgcctt tggctgggtg caacttccat
       61 tttaggtgtt ggatctgagg gggaaaaaaa agagagaggg agagagagag aaagaagagc
      121 aggaaagatc ccgaaaggag gaagaggtgg cgaaaaatca actgccctgc tggatttgtc
      181 tttctcagca ccttggcgaa gccttgggtt tctttcttaa aggactgatt tttagaactc
      241 cacatttgag gtgtgtggct tttgaagaaa atgtatgtac tgacgggaaa aggaagataa
      301 gcaagtcgaa tttttgtctt acgctctctc cttcctgctt cctccttgct gtggtggctg
      361 ggatgctcct tccatgattt tttgaatcta gactgggctg ttctctgtgt taaaccaatc
      421 agttgcgacc ttctcttaac agtgtgaagt gagggggtct ctctccctcc ttctccttcc
      481 tctgtgattc accttccttt ttaccctgcc ctgcggcggc tccgcccctt accttcatgg
      541 acgactcaga ggtggagtcg accgccagca tcttggcctc tgtgaaggaa caagaggccc
      601 agtttgagaa gctgacccgg gcgctggagg aggaacggcg ccacgtctcg gcgcagctgg
      661 aacgcgtccg ggtctcacca caagatgcca acccactcat ggccaacggc acactcaccc
      721 gccggcatca gaacggccgg tttgtgggcg atgctgacct tgaaagacag aaattttcag
      781 atttgaaact caacggaccc caggatcaca gtcaccttct atatagcacc atccccagga
      841 tgcaggagcc ggggcagatt gtggagacct acacggagga ggatcctgag ggagccatgt
      901 ctgtagtctc tgtggagacc tcagatgatg ggaccactcg gcgcacagag accacggtca
      961 agaaagtagt gaagactgtg acaacacgga cagtacagcc agtcgctatg ggaccagacg
     1021 ggttgcctgt ggatgcttca tcagtttcta acaactatat ccagactttg ggtcgtgatt
     1081 tccgcaagaa tggcaatggg ggacctggtc cctatgtggg gcaagctggc actgctaccc
     1141 ttcctaggaa cttccactac cctcctgatg gttatagtcg ccactatgaa gatggttatc
     1201 caggtggcag tgataactat ggcagtctgt cccgggtgac ccgcattgag gagcggtata
     1261 ggcccagcat ggaaggctac cgggcaccta gtagacagga tgtgtatggg ccccaacccc
     1321 aggttcgggt aggtgggagc agcgtggatc tgcatcgctt tcatccagag ccttatgggc
     1381 tagaggatga ccagcgtagt atgggctatg atgacctgga ttatggtatg atgtctgatt
     1441 atggcactgc ccgtcggact gggacaccct ctgaccctcg tcggcgcctc aggagctatg
     1501 aagacatgat tggtgaggag gtgccatcgg atcaatacta ctgggctcct ttggcccagc
     1561 atgagcgagg aagtttagca agcttggata gcctgcgcaa aggagggcct ccacctccta
     1621 attggagaca gccagagctg ccagaggtga tcgccatgct tggattccgc ttggatgctg
     1681 tcaagtccaa tgcagctgca tacctgcaac acttatgcta ccgcaatgac aaggtgaaga
     1741 ctgacgtgcg gaagctcaag ggcatcccag tactggtggg attgttagac catcccaaaa
     1801 aggaagtgca ccttggagcc tgtggagctc tcaagaatat ctcttttgga cgtgaccagg
     1861 ataacaagat tgccataaaa aactgtgatg gtgtgcctgc ccttgtgcga ttgcttcgaa
     1921 aggctcgtga tatggacctt actgaagtta ttaccggaac cctgtggaat ctttcatccc
     1981 atgactcaat caaaatggag attgtggacc atgcactgca tgccttgaca gatgaagtga
     2041 tcattcctca ttctggttgg gagcgggaac ctaatgaaga ctgtaagcca cgccatattg
     2101 agtgggaatc ggtgctcacc aacacagctg gctgccttag gaatgtaagc tcagagagga
     2161 gtgaagctcg ccggaaactt cgggaatgtg atggtttagt tgatgccctc attttcattg
     2221 ttcaggctga gattgggcag aaggattcag acagcaagct tgtagagaac tgtgtttgcc
     2281 ttcttcggaa cttatcatat caagttcacc gggagatccc acaggcagag cgttaccaag
     2341 aggcagctcc caatgttgcc aacaatactg ggccacatgc tgccagttgc tttggggcca
     2401 agaagggcaa agggaaaaaa cctatagagg atccagcaaa cgatacagtg gatttcccta
     2461 aaagaacgag tccagctcga ggctatgagc tcttatttca gccagaggtg gttcggatat
     2521 acatctcact tcttaaggag agcaagactc ctgccatcct agaagcctca gctggagcta
     2581 tccagaactt gtgtgctggg cgctggacgt atggtcgata catccgctct gctctgcgtc
     2641 aagagaaggc tctttctgcc atagctgacc tcctgactaa tgaacatgaa cgggtggtga
     2701 aagctgcatc tggagcactg agaaacctgg ctgtggatgc tcgcaacaaa gaattaattg
     2761 gtaaacatgc tattcctaac ttggtaaaga atctgccagg aggacagcag aactcctctt
     2821 ggaatttctc tgaggacact gtcatctcta ttttgaacac tatcaacgag gttatcgctg
     2881 agaacttgga ggctgccaaa aagcttcgag agacacaggg tattgagaag ctggtgttga
     2941 tcaacaaatc agggaaccgc tcagaaaaag aagttcgagc agcagcactt gtattacaga
     3001 caatctgggg atataaggaa ctgcggaagc cactggaaaa agaaggatgg aagaaatcag
     3061 actttcaggt gaatctaaac aatgcttccc gaagccagag cagtcattca tatgatgata
     3121 gtactctccc tctcattgac cggaaccaaa aatcagataa caactattcc acaccaaatg
     3181 agagaggaga ccacaataga acactggatc gatcggggga tctaggcgac atggagccat
     3241 tgaagggaac aacacccttg atgcaggacg aggggcagga atctctggag gaagagttgg
     3301 atgtgttggt tttggatgat gaggggggcc aagtgtctta cccctccatg cagaagattt
     3361 agcaccacta tctccgttcc atctgggctt atatgtactt ttattttttg gtggtgaaat
     3421 tgactgatga ttttcctttt tcttcgctgg actattgtgc caactgccag gctgcctcct
     3481 gcccttacag ccctaagtgg ctgccttctt tccatcaact cccaacttct tcctgtgaag
     3541 tttaattgtc tcaacgcctc cccctccccc attccctcca tttttctccc aagaaacctg
     3601 actcaattat ttgcatattt tgagaaactg ctgcagatta gttctttttg ccagttttcc
     3661 ctggaactcc tggccttttg tggaggggag ggatggagag aataggaatc ttcactagaa
     3721 gccgtgggaa gaattggaag ttacatgctg tatatgcaat gtccagcagt ctgataaact
     3781 gacgattctt aatcaagatt tttttcctga tggggaaggg acttttattt tcttttagag
     3841 aggggaaagt gtgagctctt cccttattcc taatggctat ttttgaagca aagaaggcca
     3901 gcaacattgg cacatgccac ctggcaaagg acccttgagt aagtgaaggt ctcctaaaac
     3961 tgggattaag aaaccttgct ctcctcatct ccaaggcagg gaccatcaag aacctacaga
     4021 ctccatctct tctgcaagcc tcatgccaac cctgggctat tgctgctgcc ccttaaacac
     4081 aggctgtcct taacccacct ctcctgccct gtgatatgtc tgctgagttg gcctggccat
     4141 ttccaagagg ctgtagaaag gggagaatgt caaggaagac ttttggtaga gaaggagcag
     4201 aaagatgtgt ttttgggaag aagaagacct ctaggaggag ctagtaggaa tgtacatgaa
     4261 gcaattagtc tgaaactggc ttccccactc ccccgtttct ccttttccta tccttatagg
     4321 cctgtccctt gcctctgccc tggattggtt ggcaaactat aggacttgat gtacataact
     4381 cctgtccctt ttcccttaca aggtggggat tgcccctggc tttgcctctt ctttgtgcct
     4441 ttggcctggg gtgcatctcc tcccgccctt ccatgtgcct ttctttgcct ctgcagtctc
     4501 atttctcata attttgcaaa ttatattttg ttgctttctt acctactatt ggccctaaat
     4561 agcagaaaga agagaagtga ccgagagaac ctcagattct tcattgagga ttggtatagc
     4621 catgatttca gtcatagcaa gcttttgctc aacagcatat gggtgggatt tggcaaaaat
     4681 cctattctga tgaatctcaa agtaaggctg gtaagagaag tgagtggtgt gactcttact
     4741 ccttaggtgc ccagaattta ccatcatctc tgaaggagtt acagggaagt ggtctcccca
     4801 attctcccct ccctccagta ttgccccctc tcactttagc atatattaat tagcaggttg
     4861 ggctagagaa atcagctgct atgcgggttg attattatta ttatttctaa tccttttcct
     4921 tatttgcctt ctactcccct taatctaatc taaaagctct gttccatgca actggagttc
     4981 cttatccctc tcttcccctt cccttatata ttgaggctat ggggtaggag aaaagtgcac
     5041 aacccaccac cccctctact cgtgcattaa aatttcttat ttaccctttt cccccttccc
     5101 atttcttccc actttcatct accttttctg gcaaaaagga gccttttgct ctctgtgacc
     5161 ctaagagcac actgcacagg gaaaattgcc ccatccagac ctggctccac tcttgatctc
     5221 tcttgtcctc ttctgctctt ttcctggtgc tcttttttct cggtggggtg tgggtaatag
     5281 aacagccgtg ggcttttggg gacctttaac ttttttttct ctcttttgtt tataaaaaac
     5341 actaaacatt caattccaga gaacccaaaa tcccaccttc ccaccgaaca ctactaaggg
     5401 gcttgtgttc tgctccatac cttttctctt ttctttctgt cttgttaatg cttttaaaaa
     5461 caaatgagtt ttttatataa ataaagtttt taaagtgtgt atgtgggggg tctgtgtcat
     5521 ttcttcactt caagctgtta tttcttccct gctttgcatc tttgttactt ccttatgtat
     5581 cagtgtcctt tccagagcaa ccagaaggag gttataccag gatttatttt gagctcagcc
     5641 ccaactcttt atcaagcaac attcttgtta actatatgtg aaacattttt tcttctgaag
     5701 attcttaaaa attgaatgtg gctgaagttg aacatgggag cttattgcta atttagagat
     5761 aggaaactga agcataaaga attaatgact tactttaatt actggaattc ttctgcaaca
     5821 tttgacaaaa ctaaccttga ataaggccca ctgtaatacg tagctctctt aaatataaca
     5881 cttaggacta gaagattaga aactaccaat cccaactacg taataggaaa atgtaggatc
     5941 aaaaggccca tgtatataag tactgaccac tgggccataa tgttgcttct caggctatat
     6001 gcagtccttt agtcagaagt caataggcct atttattaat attttacaga ccatattacc
     6061 tggattacca gggactatct ttgctgcaga gatcaagggt taagatctat gggaagatac
     6121 ttatttttct gaggtcctta tgtcctgtca tataattaaa gactcaagag aatttatgtg
     6181 aaatgctttc tgtatgcccc aatctttaga ttaaaattat atacctgctc ct
//

LOCUS       NM_001421               4190 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens E74-like factor 4 (ets domain transcription factor)
            (ELF4), mRNA.
ACCESSION   NM_001421
VERSION     NM_001421.1  GI:4503554
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4190)
  AUTHORS   Suico,M.A., Yoshida,H., Seki,Y., Uchikawa,T., Lu,Z., Shuto,T.,
            Matsuzaki,K., Nakao,M., Li,J.D. and Kai,H.
  TITLE     Myeloid Elf-1-like factor, an ETS transcription factor,
            up-regulates lysozyme transcription in epithelial cells through
            interaction with promyelocytic leukemia protein
  JOURNAL   J. Biol. Chem. 279 (18), 19091-19098 (2004)
   PUBMED   14976184
  REMARK    GeneRIF: promyelocytic leukemia protein, but not Sp100, induced the
            accumulation of MEF in PML nuclear bodies and MEF and PML
            physically interacted, stimulating MEF transcriptional activity,
            resulting in the up-regulation of endogenous lysozyme expression.
REFERENCE   2  (bases 1 to 4190)
  AUTHORS   Lu,Z., Kim,K.A., Suico,M.A., Shuto,T., Li,J.D. and Kai,H.
  TITLE     MEF up-regulates human beta-defensin 2 expression in epithelial
            cells
  JOURNAL   FEBS Lett. 561 (1-3), 117-121 (2004)
   PUBMED   15013761
  REMARK    GeneRIF: MEF activated HBD2 promoter activity, and increased the
            endogenous HBD2 transcription level. The activated HBD2 promoter
            activity was attenuated by the antisense MEF RNA input and the loss
            of the ETS binding site in the HBD2 promoter
REFERENCE   3  (bases 1 to 4190)
  AUTHORS   Hedvat,C.V., Yao,J., Sokolic,R.A. and Nimer,S.D.
  TITLE     Myeloid ELF1-like factor is a potent activator of interleukin-8
            expression in hematopoietic cells
  JOURNAL   J. Biol. Chem. 279 (8), 6395-6400 (2004)
   PUBMED   14625302
  REMARK    GeneRIF: MEF is an important regulator of IL-8 expression
REFERENCE   4  (bases 1 to 4190)
  AUTHORS   Suico,M.A., Koyanagi,T., Ise,S., Lu,Z., Hisatsune,A., Seki,Y.,
            Shuto,T., Isohama,Y., Miyata,T. and Kai,H.
  TITLE     Functional dissection of the ETS transcription factor MEF
  JOURNAL   Biochim. Biophys. Acta 1577 (1), 113-120 (2002)
   PUBMED   12151102
  REMARK    GeneRIF: Functional dissection of the transactivation mechanisms of
            the ETS transcription factor MEF
REFERENCE   5  (bases 1 to 4190)
  AUTHORS   Aryee,D.N., Petermann,R., Kos,K., Henn,T., Haas,O.A. and Kovar,H.
  TITLE     Cloning of a novel human ELF-1-related ETS transcription factor,
            ELFR, its characterization and chromosomal assignment relative to
            ELF-1
  JOURNAL   Gene 210 (1), 71-78 (1998)
   PUBMED   9524226
REFERENCE   6  (bases 1 to 4190)
  AUTHORS   Miyazaki,Y., Sun,X., Uchida,H., Zhang,J. and Nimer,S.
  TITLE     MEF, a novel transcription factor with an Elf-1 like DNA binding
            domain but distinct transcriptional activating properties
  JOURNAL   Oncogene 13 (8), 1721-1729 (1996)
   PUBMED   8895518
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U32645.1.
FEATURES             Location/Qualifiers
     source          1..4190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26"
     gene            1..4190
                     /gene="ELF4"
                     /note="synonyms: MEF, ELFR"
                     /db_xref="GeneID:2000"
     CDS             383..2374
                     /gene="ELF4"
                     /note="go_component: nucleus [goid 0005634] [evidence
                     IEA];
                     go_component: nucleus [goid 0005634] [evidence NAS];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence NAS];
                     go_function: transcription coactivator activity [goid
                     0003713] [evidence TAS] [pmid 8895518];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence TAS] [pmid 8895518];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence NAS]"
                     /codon_start=1
                     /product="E74-like factor 4 (ets domain transcription
                     factor)"
                     /protein_id="NP_001412.1"
                     /db_xref="GI:4503555"
                     /db_xref="GeneID:2000"
                     /translation="MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPD
                     LLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNME
                     SPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEE
                     KASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLAL
                     LQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRG
                     ILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASASTTRRTSSRV
                     SSRSAPQGKGSSSWEKPKIQHVGLQPSASLELGPSLDEEIPTTSTMLVSPAEGQVKLT
                     KAVSASSVPSNIHLGVAPVGSGSALTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPAA
                     STFKDTFTLQASFPLNASFQDSQVAAPGAPLILSGLPQLLAGANRPTNPAPPTVTGAG
                     PAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGPLRSSSYVQGMVTGAPMEGLLVPEETL
                     RELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLSPPSRPTVGLTPVAELELSSGSGSL
                     LMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEPHDI"
ORIGIN      
        1 gaattccctt tcgccggcgc cgagttcctg gcgccgctcg cccggcccgg cttccgaggg
       61 gagaggacgg gctggcgggg ctggggaccc gcgtctcggc ccccggagcg gggaccacgg
      121 agacagaccc cggcccggcg accgagctgg gcccgtgagc cactcggcct caggtcgctc
      181 ctgtggttgg tccagcccag aatgcagcct tgagcctggc ttaggccacc acctactcca
      241 gctctctcca ccccctattt tactgcagct cagggggtag gctctaggct ccaaagtacc
      301 tgggtattgt cccttcatca agaaagcccc acagctctgg agggctctga taatcccgtt
      361 gtcagctctc tgaaaagaca gcatggctat taccctacag cccagtgacc tgatctttga
      421 gttcgcaagc aacgggatgg atgatgatat ccaccagctg gaagacccct ctgtgttccc
      481 agctgtgatc gtggagcagg taccctaccc tgatttactg catctgtact cgggactgga
      541 gttggacgac gttcacaatg gcatcataac agacgggacc ttgtgcatga cccaggatca
      601 gatcctggaa ggcagttttt tgctgacaga tgacaatgag gccacctcgc acaccatgtc
      661 aaccgcggaa gtcttactca atatggagtc tcccagcgat atcctggatg agaagcagat
      721 cttcagtacc tccgaaatgc ttccagactc ggaccctgca ccagctgtca ctctgcccaa
      781 ctacctgttt cctgcctctg agcccgatgc cctgaacagg gcgggtgaca ctagtgacca
      841 ggaggggcat tctctggagg agaaggcctc cagagaggaa agtgccaaga agactgggaa
      901 atcaaagaag agaatccgga agaccaaggg caaccgaagt acctcacctg tcactgaccc
      961 cagcatcccc attaggaaga aatcaaagga tggcaaaggc agcaccatct atctgtggga
     1021 gttcctcctg gctcttctgc aagacagaaa cacctgtccc aagtacatca agtggaccca
     1081 gcgagagaaa ggcatcttca aactggtgga ctccaaagct gtgtccaagc tgtgggggaa
     1141 gcagaaaaac aagcctgaca tgaactatga gacaatgggg cgggcactaa gatactacta
     1201 ccaaagaggc atactggcca aagtggaagg gcagaggctg gtgtaccagt ttaaggagat
     1261 gcccaaggac ctggtggtca ttgaagatga ggatgagagc agcgaagcca cagcagcccc
     1321 acctcaggcc tccacggcct ctgtggcctc tgccagtacc acccggcgaa ccagctccag
     1381 ggtctcatcc agatctgccc cccagggcaa gggcagctct tcttgggaga agccaaaaat
     1441 tcagcatgtc ggtctccagc catctgcgag tctggaattg ggaccgtcgc tagacgagga
     1501 gatccccact acctccacca tgctcgtctc tccagcagag ggccaggtca agctcaccaa
     1561 agctgtgagt gcatcttcag tgcccagcaa catccaccta ggagtggccc ccgtggggtc
     1621 gggctcggcc ctgaccctgc agacgatccc actgaccacg gtgctgacca atgggcctcc
     1681 tgccagtact actgctccca ctcagctcgt tctccagagt gttccagcgg cctctacttt
     1741 caaggacacc ttcactttgc aggcctcttt ccccctgaac gccagtttcc aagacagcca
     1801 ggtggcagcc ccaggggctc cactgattct cagtggcctc ccccaacttc tggctggggc
     1861 caaccgtccg accaacccgg cgccacccac ggtcacaggg gctggaccag cagggcccag
     1921 ctctcagccc cctgggactg tcattgctgc cttcatcagg acttctggca ctacagcagc
     1981 ccctagggtc aaggaggggc cactgaggtc ctcctcctat gttcagggta tggtgacggg
     2041 ggcccccatg gaggggctgc tggttcctga agagaccctg agggagctcc tgagagatca
     2101 ggctcatctt cagccacttc caacccaggt ggtttccagg ggttcccaca atccgagcct
     2161 tctgggcaac cagactttgt ctcctcccag ccgccccact gttgggctga ccccagtggc
     2221 tgaacttgag ctctcctcag gctcagggtc cctgctgatg gctgagccta gtgtgaccac
     2281 atctgggagc cttctgacaa gatcccccac cccagcccct ttctccccat tcaaccctac
     2341 ttccctcatt aagatggagc cccatgacat ataagcaaag gggtcagggc aagtgtgacc
     2401 caccaggcaa aattgagcag cattttcata gggaccgact tcagtagcac acctgcccct
     2461 gcatttcagt gggatgtcaa tacacttgac cccaagtccc ccggccctgc ctggtgtcac
     2521 tgtggccaaa cagtgcccag cttaagcatc cctggcatca gactatggcc ttcaagagca
     2581 ctagggcata tgcttttggc agcataacgg gctgacttgg tgatggaggg aaaaagcctt
     2641 gagccaggca gaagtttgtg gccagggttt gtgcagcagc tttgtgagaa gagcccttct
     2701 acctggctct atctcactgg ctgcattccc tacacaggga atttactacc ctatatgtga
     2761 atatcccctg tatgtacttg tgtgtacttg ttggtctgta tcttagtttc tttggggagg
     2821 acagggctgt agctgtgagg tcttgtctcc aagggtgtgt gtatgtctcc gtggatcagc
     2881 cacagggata gggattttgt ttttaaggga aagcattctc taattccctt tgttcatgcc
     2941 gagattcagt tgctctgaga ctatggggta caagtttgat cctccgaatc tggagatgtt
     3001 gtagagctgg aacgagtgca gagtaggaac gctttgatgc gcatgcacat tggggaagat
     3061 gcgctcctca gggacacaaa ggccgagtgg ggtaaaacca cgaagggagg gaagggaagt
     3121 cagctctggg agcagccctc actggctgga ccaaggtact cttcctggag tttgccgtgt
     3181 tagcaaccac agtcaccttg cagtcaggct ggaatcttgg gccaccccac agtgctttgc
     3241 tgtaggattt agacggggat gaagtgccct ccagcctcag agctagccac aaagccccca
     3301 gagctgaatt cattgagtat ttgtgcctag ggcttgggct gtttgtgtga taccggcccc
     3361 ccgacagaca ataggctgtg atgacacccc agtctacttc cccgatcctg ggctccctct
     3421 tgattagtag gtgacatttt ccactgtcag gcatcactgg ggctagtccg gcagcgacct
     3481 agatggggtc cacccccatt cctgctcaag catgggcacc taccacatgg tttctgctgc
     3541 tcagcctgac tgcaactcac ctcgaaggcg gaccagcctg cctctgtgat gactgcagaa
     3601 gacctccttg ggtgtaccaa tgcccctcat ctcccacttt cacacctaac cctgactcct
     3661 tcaccaagaa gacgggagtc ggcagccagg agttcccgtg gcacctctct ctcttcgtgg
     3721 ctccctgctt cccccttccc tctttccgag gaagggtcaa cctattctct ctcaaaacca
     3781 acccctaggc caattgcctg gatctcctcc cctctccctt ctttaaacga gcttgcctcc
     3841 ctcctgccaa gtttgagggc aaggctaaga aatgtcagcc acggaaacaa ctctaatatc
     3901 tggtgacttt gggtaatgtg aatcagtgcc tgaggacctt tgctgtgtcc ttggtacaga
     3961 accatccact tgacctaact acctcccctg gccgcgctct cgctcttctc ttctttgtta
     4021 agccaacaac tatcaccctc tcctactctt ctttctccct gccccctgga gggcactgtg
     4081 tttggttgtg caaatgtatt tactatgcgt gtttccagca gttggcatta aagtgccttt
     4141 ttctaataaa atcagtttat tatgaccaaa aaaaaaaaaa aaaggaattc
//

LOCUS       NM_001497               4080 bp    mRNA    linear   PRI 16-DEC-2004
DEFINITION  Homo sapiens UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
            polypeptide 1 (B4GALT1), mRNA.
ACCESSION   NM_001497
VERSION     NM_001497.2  GI:13929461
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4080)
  AUTHORS   Hansske,B., Thiel,C., L, Hasilik,M., H, Peters,V., Heidemann,P.H.,
            Hoffmann,G.F., Berger,E.G., von Figura,K. and K.
  TITLE     Deficiency of UDP-galactose:N-acetylglucosamine
            beta-1,4-galactosyltransferase I causes the congenital disorder of
            glycosylation type IId
  JOURNAL   J. Clin. Invest. 109 (6), 725-733 (2002)
  MEDLINE   21898392
   PUBMED   11901181
  REMARK    GeneRIF: deficiency causes a new congenital disorder of
            glycosylation (CDG), designated type IId (CDG-IId), a severe
            neurologic disease characterized by hydrocephalus, myopathy, and
            blood-clotting defects
REFERENCE   2  (bases 1 to 4080)
  AUTHORS   Schnyder-Candrian,S., Borsig,L., Moser,R. and Berger,E.G.
  TITLE     Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade
            bodies of human endothelial cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (15), 8369-8374 (2000)
  MEDLINE   20359713
   PUBMED   10900002
REFERENCE   3  (bases 1 to 4080)
  AUTHORS   Amado,M., Almeida,R., Schwientek,T. and Clausen,H.
  TITLE     Identification and characterization of large galactosyltransferase
            gene families: galactosyltransferases for all functions
  JOURNAL   Biochim. Biophys. Acta 1473 (1), 35-53 (1999)
  MEDLINE   20047730
   PUBMED   10580128
REFERENCE   4  (bases 1 to 4080)
  AUTHORS   Lo,N.W., Shaper,J.H., Pevsner,J. and Shaper,N.L.
  TITLE     The expanding beta 4-galactosyltransferase gene family: messages
            from the databanks
  JOURNAL   Glycobiology 8 (5), 517-526 (1998)
  MEDLINE   98259838
   PUBMED   9597550
REFERENCE   5  (bases 1 to 4080)
  AUTHORS   Kudo,T. and Narimatsu,H.
  TITLE     The beta 1,4-galactosyltransferase gene is post-transcriptionally
            regulated during differentiation of mouse F9 teratocarcinoma cells
  JOURNAL   Glycobiology 5 (4), 397-403 (1995)
  MEDLINE   96078407
   PUBMED   7579794
REFERENCE   6  (bases 1 to 4080)
  AUTHORS   Chatterjee,S.K., Mukerjee,S. and Tripathi,P.K.
  TITLE     Analysis of the sequences of human beta-1,4-galactosyltransferase
            cDNA clones
  JOURNAL   Int. J. Biochem. Cell Biol. 27 (3), 329-336 (1995)
  MEDLINE   95299971
   PUBMED   7540104
REFERENCE   7  (bases 1 to 4080)
  AUTHORS   Uejima,T., Uemura,M., Nozawa,S. and Narimatsu,H.
  TITLE     Complementary DNA cloning for galactosyltransferase associated with
            tumor and determination of antigenic epitopes recognized by
            specific monoclonal antibodies
  JOURNAL   Cancer Res. 52 (22), 6158-6163 (1992)
  MEDLINE   93046112
   PUBMED   1384956
REFERENCE   8  (bases 1 to 4080)
  AUTHORS   Mengle-Gaw,L., McCoy-Haman,M.F. and Tiemeier,D.C.
  TITLE     Genomic structure and expression of human
            beta-1,4-galactosyltransferase
  JOURNAL   Biochem. Biophys. Res. Commun. 176 (3), 1269-1276 (1991)
  MEDLINE   91248214
   PUBMED   1903938
REFERENCE   9  (bases 1 to 4080)
  AUTHORS   Watzele,G. and Berger,E.G.
  TITLE     Near identity of HeLa cell galactosyltransferase with the human
            placental enzyme
  JOURNAL   Nucleic Acids Res. 18 (23), 7174 (1990)
  MEDLINE   91088335
   PUBMED   2124683
REFERENCE   10 (bases 1 to 4080)
  AUTHORS   Masri,K.A., Appert,H.E. and Fukuda,M.N.
  TITLE     Identification of the full-length coding sequence for human
            galactosyltransferase (beta-N-acetylglucosaminide: beta
            1,4-galactosyltransferase)
  JOURNAL   Biochem. Biophys. Res. Commun. 157 (2), 657-663 (1988)
  MEDLINE   89076299
   PUBMED   3144273
REFERENCE   11 (bases 1 to 4080)
  AUTHORS   Appert,H.E., Rutherford,T.J., Tarr,G.E., Wiest,J.S., Thomford,N.R.
            and McCorquodale,D.J.
  TITLE     Isolation of a cDNA coding for human galactosyltransferase
  JOURNAL   Biochem. Biophys. Res. Commun. 139 (1), 163-168 (1986)
  MEDLINE   87025694
   PUBMED   3094506
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X55415.1 and D29805.1.
            On May 2, 2001 this sequence version replaced gi:4502344.
            
            Summary: This gene is one of seven beta-1,4-galactosyltransferase
            (beta4GalT) genes. They encode type II membrane-bound glycoproteins
            that appear to have exclusive specificity for the donor substrate
            UDP-galactose; all transfer galactose in a beta1,4 linkage to
            similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a
            distinct function in the biosynthesis of different glycoconjugates
            and saccharide structures. As type II membrane proteins, they have
            an N-terminal hydrophobic signal sequence that directs the protein
            to the Golgi apparatus and which then remains uncleaved to function
            as a transmembrane anchor. By sequence similarity, the beta4GalTs
            form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and
            beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is
            unique among the beta4GalT genes because it encodes an enzyme that
            participates both in glycoconjugate and lactose biosynthesis. For
            the first activity, the enzyme adds galactose to
            N-acetylglucosamine residues that are either monosaccharides or the
            nonreducing ends of glycoprotein carbohydrate chains. The second
            activity is restricted to lactating mammary tissues where the
            enzyme forms a heterodimer with alpha-lactalbumin to catalyze
            UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic
            forms result from alternate transcription initiation sites and
            post-translational processing. Two transcripts, which differ only
            at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode
            the same protein. The longer transcript encodes the type II
            membrane-bound, trans-Golgi resident protein involved in
            glycoconjugate biosynthesis. The shorter transcript encodes a
            protein which is cleaved to form the soluble lactose synthase.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13"
     gene            1..4080
                     /gene="B4GALT1"
                     /note="synonyms: GT1, GTB, GGTB2, B4GAL-T1, beta4Gal-T1"
                     /db_xref="GeneID:2683"
                     /db_xref="MIM:137060"
     CDS             73..1269
                     /gene="B4GALT1"
                     /EC_number="2.4.1.22"
                     /EC_number="2.4.1.90"
                     /EC_number="2.4.1.38"
                     /note="lactose synthase A protein;
                     glycoprotein-4-beta-galactosyltransferase 2;
                     UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 1;
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     TAS] [pmid 10900002];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: galactosyltransferase activity [goid 0008378]
                     [evidence NAS] [pmid 7540104];
                     go_function: N-acetyllactosamine synthase activity [goid
                     0003945] [evidence IEA];
                     go_function: transferase activity, transferring glycosyl
                     groups [goid 0016757] [evidence IEA];
                     go_function: beta-N-acetylglucosaminylglycopeptide
                     beta-1,4-galactosyltransferase activity [goid 0003831]
                     [evidence IEA];
                     go_process: carbohydrate metabolism [goid 0005975]
                     [evidence IEA];
                     go_process: oligosaccharide biosynthesis [goid 0009312]
                     [evidence NAS] [pmid 7540104]"
                     /codon_start=1
                     /product="UDP-Gal:betaGlcNAc beta 1,4-
                     galactosyltransferase 1, membrane-bound form"
                     /protein_id="NP_001488.2"
                     /db_xref="GI:13929462"
                     /db_xref="GeneID:2683"
                     /db_xref="MIM:137060"
                     /translation="MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAG
                     RDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSP
                     VVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPN
                     VKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAG
                     DTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKF
                     GFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAV
                     VGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITV
                     DIGTPS"
     mat_peptide     304..1266
                     /gene="B4GALT1"
                     /product="beta-1,4-galactosyltransferase 1, soluble form"
                     /EC_number="2.4.1.22"
                     /note="a component of lactose synthase; milk
                     galactosyltransferase"
     polyA_signal    4060..4065
                     /gene="B4GALT1"
ORIGIN      
        1 gcgcctgcgg cgccgcgggc gggtcgcctc ccctcctgta gcccacaccc ttcttaaagc
       61 ggcggcggga agatgaggct tcgggagccg ctcctgagcg gcagcgccgc gatgccaggc
      121 gcgtccctac agcgggcctg ccgcctgctc gtggccgtct gcgctctgca ccttggcgtc
      181 accctcgttt actacctggc tggccgcgac ctgagccgcc tgccccaact ggtcggagtc
      241 tccacaccgc tgcagggcgg ctcgaacagt gccgccgcca tcgggcagtc ctccggggag
      301 ctccggaccg gaggggcccg gccgccgcct cctctaggcg cctcctccca gccgcgcccg
      361 ggtggcgact ccagcccagt cgtggattct ggccctggcc ccgctagcaa cttgacctcg
      421 gtcccagtgc cccacaccac cgcactgtcg ctgcccgcct gccctgagga gtccccgctg
      481 cttgtgggcc ccatgctgat tgagtttaac atgcctgtgg acctggagct cgtggcaaag
      541 cagaacccaa atgtgaagat gggcggccgc tatgccccca gggactgcgt ctctcctcac
      601 aaggtggcca tcatcattcc attccgcaac cggcaggagc acctcaagta ctggctatat
      661 tatttgcacc cagtcctgca gcgccagcag ctggactatg gcatctatgt tatcaaccag
      721 gcgggagaca ctatattcaa tcgtgctaag ctcctcaatg ttggctttca agaagccttg
      781 aaggactatg actacacctg ctttgtgttt agtgacgtgg acctcattcc aatgaatgac
      841 cataatgcgt acaggtgttt ttcacagcca cggcacattt ccgttgcaat ggataagttt
      901 ggattcagcc taccttatgt tcagtatttt ggaggtgtct ctgctctaag taaacaacag
      961 tttctaacca tcaatggatt tcctaataat tattggggct ggggaggaga agatgatgac
     1021 atttttaaca gattagtttt tagaggcatg tctatatctc gcccaaatgc tgtggtcggg
     1081 aggtgtcgca tgatccgcca ctcaagagac aagaaaaatg aacccaatcc tcagaggttt
     1141 gaccgaattg cacacacaaa ggagacaatg ctctctgatg gtttgaactc actcacctac
     1201 caggtgctgg atgtacagag atacccattg tatacccaaa tcacagtgga catcgggaca
     1261 ccgagctagc gttttggtac acggataaga gacctgaaat tagccaggga cctctgctgt
     1321 gtgtctctgc caatctgctg ggctggtccc tctcattttt accagtctga gtgacagctc
     1381 cccttggctc atcattcaga tggctttcca gatgaccagg acaggtggga tattttgccc
     1441 ccaacttggc tcggcatgtg aattcttagc tctgcaaggt gtttatgcct ttgcgggttt
     1501 cttgatgtgt tcgcagtgtc acccaagagt cagaactgta gacatcccaa aatttggtgg
     1561 ccgtggaaca cattcccggt gatagaattg ctaaattgtc gtgaaatagg ttagaatttt
     1621 tctttaaatt atggttttct tattcgcgaa aattcggaga gtgctgctaa aattggattg
     1681 gtgtcatctt tttggtagtt gtaatttaac agaaaaacac aaaatttcaa ccattcttaa
     1741 tgttacgtcc tccccccacc cccttctttc agtggtatgc aaccactgca atcaatgtgt
     1801 catatgtctt ttcttagcaa aaggatttaa aacttgagcc ctggaccttt tgcctatgtg
     1861 tgtggattcc agggcaactc tagcatcaga gcaaaagcct tgggtttctc gcattcagtg
     1921 gcctatctcc agattgtctg atttctgaat gtaaagttgt tgtgtttttt tttaaatagt
     1981 aggtttgtag tattttaaag aaagaacaga tcgagttcta attatgatct agcttgattt
     2041 tgtgttgatc caaatttgca tagctgttta atgttaagtc atgacaattt atttttcttg
     2101 gcatgctatg taaacttgaa tttcctaagt atttttattc tggtgtttta aatatgggga
     2161 ggggtattga gcatttttta gggagaaaaa taaatatatg ctgtagtggc cacaaatagg
     2221 cctatgattt agctggcagg ccaggttttc tcaagagcaa aatcaccctc tggccccttg
     2281 gcaggtaagg cctcccggtc agcattatcc tgccagacct cggggaggat acctgggaga
     2341 cagaagcctc tgcacctact gtgcagaact ctccacttcc ccaaccctcc ccaggtgggc
     2401 agggcggagg gagcctcagc ctccttagac tgacccctca ggcccctagg ctggggggtt
     2461 gtaaataaca gcagtcaggt tgtttaccag ccctttgcac ctccccaggc agagggagcc
     2521 tctgttctgg tgggggccac ctccctcaga ggctctgcta gccacactcc gtggcccacc
     2581 ctttgttacc agttcttcct ccttcctctt ttcccctgcc tttctcattc cttccttcgt
     2641 ctcccttttt gttcctttgc ctcttgcctg tcccctaaaa cttgactgtg gcactcaggg
     2701 tcaaacagac tatccattcc ccagcatgaa tgtgcctttt aattagtgat ctagaaagaa
     2761 gttcagccgc acccacaccc caactccctc ccaagaactt cggtcctaaa gcctcctgtt
     2821 ccacctcagg ttttcacagg tgctcacacc acagttgagg ctcacacaca ggtctgtctg
     2881 tcacaaaccc acctctgttg ggagctattg agccacctgg gatgagatga cacaagacac
     2941 tcctaccact gagcgccttt gtccaggtgc cagcctgggc tcaggttcca agactcagct
     3001 gcctaatccc agggttgagc cttgtgctcg tgtcggaccc caaaccactg ccctcctggt
     3061 accagccctc agtgtggagg ctgagctggt gcctggcccc agtcttatct gtgcctttac
     3121 tgctttgcgc atctcagatg ctaacttggt tctttttcca gaaggctttg tattggttaa
     3181 aaattatttt ctattgcaga gagcagctgt gactcatgca aaaagtattt tctctgtcag
     3241 atccccactc tataccaagg atattattaa aactagaaat gactgcattg agagggagtt
     3301 gtgggaaata agaagaatga aagcctctct ttctgtccgc agatcctgac ttttccaaag
     3361 tgccttaaaa gaaatcagac aaatgccctg agtggtaact tctgtgttat tttactctta
     3421 aaaccaaact ctaccttttc ttgttttttt tttttttttt tttttttttt ttggttacct
     3481 tctcattcat gtcaagtatg tggttcattc ttagaaccaa gggaaatact gctcccccca
     3541 tttgctgacg tagtgctctc atgggctcac ctgggcccaa ggcacagcca gggcacagtt
     3601 aggcctggat gtttgcctgg tccgtgagat gccgcgggtc ctgtttcctt actggggatt
     3661 tcagggctgg gggttcaggg agcatttcct tttcctggga gttatgtacc gcgaagtgtg
     3721 tcatgtgccg tgcccttttc tgtttctgtg tatcctattg ctggtgactc tgtgtgaact
     3781 ggcctttggg aaagatcaga gaggcagagg tggcacagga cagtaaagga gatgctgtgc
     3841 tgcctacagc ctggacaggg tctctgctgt actgccaggg gcgggggctc tgcatagcca
     3901 ggatgacgcc tttcatgtcc cagagacctg ttgtgctgtg tattttgatt tcctgtgtat
     3961 gcaaatgtgt gtatttacca ttgtgtaggg ggctgtgtct gatcttggtg ttcaaaacag
     4021 aactgtattt ttgcctttaa aattaaataa tataacgtga ataaatgacc ctaactttgt
//

LOCUS       NM_001621               5496 bp    mRNA    linear   PRI 15-OCT-2004
DEFINITION  Homo sapiens aryl hydrocarbon receptor (AHR), mRNA.
ACCESSION   NM_001621
VERSION     NM_001621.2  GI:5016091
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5496)
  AUTHORS   Marlowe,J.L., Knudsen,E.S., Schwemberger,S. and Puga,A.
  TITLE     The aryl hydrocarbon receptor displaces p300 from E2F-dependent
            promoters and represses S phase-specific gene expression
  JOURNAL   J. Biol. Chem. 279 (28), 29013-29022 (2004)
   PUBMED   15123621
  REMARK    GeneRIF: Results describe a mechanism whereby the aryl hydrocarbon
            receptor, a known transcriptional activator, mediates gene
            repression through interactions at E2F-responsive promoters,
            leading to the repression of E2F-dependent, S phase-specific genes.
REFERENCE   2  (bases 1 to 5496)
  AUTHORS   Ito,T., Tsukumo,S., Suzuki,N., Motohashi,H., Yamamoto,M.,
            Fujii-Kuriyama,Y., Mimura,J., Lin,T.M., Peterson,R.E., Tohyama,C.
            and Nohara,K.
  TITLE     A constitutively active arylhydrocarbon receptor induces growth
            inhibition of jurkat T cells through changes in the expression of
            genes related to apoptosis and cell cycle arrest
  JOURNAL   J. Biol. Chem. 279 (24), 25204-25210 (2004)
   PUBMED   15069065
  REMARK    GeneRIF: AhR activation causes apoptosis and cell cycle arrest,
            especially through expression changes in genes related to apoptosis
            and cell cycle arrest.
REFERENCE   3  (bases 1 to 5496)
  AUTHORS   Minsavage,G.D., Park,S.K. and Gasiewicz,T.A.
  TITLE     The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is
            essential for AhR DNA binding activity, is not a phosphoresidue but
            augments AhR phosphorylation
  JOURNAL   J. Biol. Chem. 279 (20), 20582-20593 (2004)
   PUBMED   14978034
  REMARK    GeneRIF: AhR tyrosine 9, which is not a phosphorylated residue
            itself but is required for DNA binding, appears to play a crucial
            role in AhR activity by permitting proper phosphorylation of the
            AhR.
REFERENCE   4  (bases 1 to 5496)
  AUTHORS   Ikuta,T., Kobayashi,Y. and Kawajiri,K.
  TITLE     Cell density regulates intracellular localization of aryl
            hydrocarbon receptor
  JOURNAL   J. Biol. Chem. 279 (18), 19209-19216 (2004)
   PUBMED   14985336
  REMARK    GeneRIF: cell density regulates the intracellular localization and
            function of AhR, because of modulation of nuclear export activity
REFERENCE   5  (bases 1 to 5496)
  AUTHORS   Morrow,D., Qin,C., Smith,R. III and Safe,S.
  TITLE     Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate
            cancer cell growth and hormone-induced transactivation
  JOURNAL   J. Steroid Biochem. Mol. Biol. 88 (1), 27-36 (2004)
   PUBMED   15026081
  REMARK    GeneRIF: Inhibitory AHR-androgen receptor crosstalk was studied in
            the LNCaP prostatic tumor cell line.
REFERENCE   6  (bases 1 to 5496)
  AUTHORS   Kinoshita,K., Kikuchi,Y., Sasakura,Y., Suzuki,M., Fujii-Kuriyama,Y.
            and Sogawa,K.
  TITLE     Altered DNA binding specificity of Arnt by selection of partner
            bHLH-PAS proteins
  JOURNAL   (er) Nucleic Acids Res. 32 (10), 3169-3179 (2004)
   PUBMED   15190133
  REMARK    GeneRIF: nucleotide preference of the heterodimers of AHR and Arnt
REFERENCE   7  (bases 1 to 5496)
  AUTHORS   Hestermann,E.V. and Brown,M.
  TITLE     Agonist and chemopreventative ligands induce differential
            transcriptional cofactor recruitment by aryl hydrocarbon receptor
  JOURNAL   Mol. Cell. Biol. 23 (21), 7920-7925 (2003)
   PUBMED   14560034
  REMARK    GeneRIF: Results describe the recruitment of aryl hydrocarbon
            receptor and associated proteins to the human cytochrome P4501A1
            gene promoter in vivo.
REFERENCE   8  (bases 1 to 5496)
  AUTHORS   Lees,M.J., Peet,D.J. and Whitelaw,M.L.
  TITLE     Defining the role for XAP2 in stabilization of the dioxin receptor
  JOURNAL   J. Biol. Chem. 278 (38), 35878-35888 (2003)
   PUBMED   12837759
  REMARK    GeneRIF: the dioxin receptor is stabilized by XAP2
REFERENCE   9  (bases 1 to 5496)
  AUTHORS   Ohtake,F., Takeyama,K., Matsumoto,T., Kitagawa,H., Yamamoto,Y.,
            Nohara,K., Tohyama,C., Krust,A., Mimura,J., Chambon,P.,
            Yanagisawa,J., Fujii-Kuriyama,Y. and Kato,S.
  TITLE     Modulation of oestrogen receptor signalling by association with the
            activated dioxin receptor
  JOURNAL   Nature 423 (6939), 545-550 (2003)
   PUBMED   12774124
  REMARK    GeneRIF: estrogen receptor-mediated estrogen signalling is
            modulated by a co-regulatory-like function of activated AhR/Arnt,
            giving rise to adverse oestrogen-related actions of dioxin-type
            environmental contaminants
REFERENCE   10 (bases 1 to 5496)
  AUTHORS   Chen,S., Nguyen,N., Tamura,K., Karin,M. and Tukey,R.H.
  TITLE     The role of the Ah receptor and p38 in
            benzo[a]pyrene-7,8-dihydrodiol and
            benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis
  JOURNAL   J. Biol. Chem. 278 (21), 19526-19533 (2003)
   PUBMED   12637498
  REMARK    GeneRIF: results confirm that the Ah receptor plays a critical role
            in B[a]P-7,8-dihydrodiol-induced apoptosis
REFERENCE   11 (bases 1 to 5496)
  AUTHORS   Moriguchi,T., Motohashi,H., Hosoya,T., Nakajima,O., Takahashi,S.,
            Ohsako,S., Aoki,Y., Nishimura,N., Tohyama,C., Fujii-Kuriyama,Y. and
            Yamamoto,M.
  TITLE     Distinct response to dioxin in an arylhydrocarbon receptor
            (AHR)-humanized mouse
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (10), 5652-5657 (2003)
   PUBMED   12730383
  REMARK    GeneRIF: In mice transgenic to this receptor, there is a lessened
            susceptibility to dioxin-induced toxicity.
REFERENCE   12 (bases 1 to 5496)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   13 (bases 1 to 5496)
  AUTHORS   Yueh,M.F., Huang,Y.H., Hiller,A., Chen,S., Nguyen,N. and Tukey,R.H.
  TITLE     Involvement of the xenobiotic response element (XRE) in Ah
            receptor-mediated induction of human UDP-glucuronosyltransferase
            1A1
  JOURNAL   J. Biol. Chem. 278 (17), 15001-15006 (2003)
   PUBMED   12566446
  REMARK    GeneRIF: Binding of ligands such as TCDD, beta-naphthoflavone, and
            benzopyrene metabolites to the Ah receptor is involved in human
            UGT1A1 induction.
REFERENCE   14 (bases 1 to 5496)
  AUTHORS   Wormke,M., Stoner,M., Saville,B., Walker,K., Abdelrahim,M.,
            Burghardt,R. and Safe,S.
  TITLE     The aryl hydrocarbon receptor mediates degradation of estrogen
            receptor alpha through activation of proteasomes
  JOURNAL   Mol. Cell. Biol. 23 (6), 1843-1855 (2003)
   PUBMED   12612060
  REMARK    GeneRIF: Inhibitory AhR-ERalpha cross talk is linked to a new
            pathway for degrading ERalpha in which TCDD initially induces
            formation of a nuclear AhR complex which coordinately recruits
            ERalpha & the proteasome complex, resulting in degradation of both
            receptors.
REFERENCE   15 (bases 1 to 5496)
  AUTHORS   Schultz,R., Suominen,J., Varre,T., Hakovirta,H., Parvinen,M.,
            Toppari,J. and Pelto-Huikko,M.
  TITLE     Expression of aryl hydrocarbon receptor and aryl hydrocarbon
            receptor nuclear translocator messenger ribonucleic acids and
            proteins in rat and human testis
  JOURNAL   Endocrinology 144 (3), 767-776 (2003)
   PUBMED   12586752
  REMARK    GeneRIF: experiments revealed a complex distribution of aryl
            hydrocarbon receptor and aryl hydrocarbon receptor nuclear
            translocator mRNAs and proteins in rat and human testis
REFERENCE   16 (bases 1 to 5496)
  AUTHORS   Trapani,V., Patel,V., Leong,C.O., Ciolino,H.P., Yeh,G.C., Hose,C.,
            Trepel,J.B., Stevens,M.F., Sausville,E.A. and Loaiza-Perez,A.I.
  TITLE     DNA damage and cell cycle arrest induced by
            2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC
            703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7
            cells
  JOURNAL   Br. J. Cancer 88 (4), 599-605 (2003)
   PUBMED   12592376
  REMARK    GeneRIF: DNA damage and cell cycle arrest induced by
            2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC
            703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7
            cells
REFERENCE   17 (bases 1 to 5496)
  AUTHORS   Hayashibara,T., Yamada,Y., Mori,N., Harasawa,H., Sugahara,K.,
            Miyanishi,T., Kamihira,S. and Tomonaga,M.
  TITLE     Possible involvement of aryl hydrocarbon receptor (AhR) in adult
            T-cell leukemia (ATL) leukemogenesis: constitutive activation of
            AhR in ATL
  JOURNAL   Biochem. Biophys. Res. Commun. 300 (1), 128-134 (2003)
   PUBMED   12480531
  REMARK    GeneRIF: Possible involvement of aryl hydrocarbon receptor (AhR) in
            adult T-cell leukemia (ATL) leukemogenesis: constitutive activation
            of AhR in ATL.
REFERENCE   18 (bases 1 to 5496)
  AUTHORS   Lin,P., Hu,S.W. and Chang,T.H.
  TITLE     Correlation between gene expression of aryl hydrocarbon receptor
            (AhR), hydrocarbon receptor nuclear translocator (Arnt),
            cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of
            CYP1A1 and CYP1B1 in human lymphocytes
  JOURNAL   Toxicol. Sci. 71 (1), 20-26 (2003)
   PUBMED   12520072
  REMARK    GeneRIF: AhR gene expression associates with individual variation
            of CYP1A1 inducibility and CYP1B1 expression in cultivated
            lymphocytes
REFERENCE   19 (bases 1 to 5496)
  AUTHORS   Harper,P.A., Wong,J.Y., Lam,M.S. and Okey,A.B.
  TITLE     Polymorphisms in the human AH receptor
  JOURNAL   Chem. Biol. Interact. 141 (1-2), 161-187 (2002)
   PUBMED   12213390
  REMARK    GeneRIF: Polymorphisms that regulate the phenotype of AHR-mediated
            responses, especially differences among ethnic groups.
REFERENCE   20 (bases 1 to 5496)
  AUTHORS   Puga,A., Xia,Y. and Elferink,C.
  TITLE     Role of the aryl hydrocarbon receptor in cell cycle regulation
  JOURNAL   Chem. Biol. Interact. 141 (1-2), 117-130 (2002)
   PUBMED   12213388
REFERENCE   21 (bases 1 to 5496)
  AUTHORS   Zhao,D., Pritts,E.A., Chao,V.A., Savouret,J.F. and Taylor,R.N.
  TITLE     Dioxin stimulates RANTES expression in an in-vitro model of
            endometriosis
  JOURNAL   Mol. Hum. Reprod. 8 (9), 849-854 (2002)
   PUBMED   12200463
  REMARK    GeneRIF: functional AhR are present in endometrial and
            endometriotic stromal cells and that TCDD up-regulates the
            expression of RANTES, providing a possible mechanistic link between
            dioxin exposure and chemokine expression in endometriosis.
REFERENCE   22 (bases 1 to 5496)
  AUTHORS   Berg,P. and Pongratz,I.
  TITLE     Two parallel pathways mediate cytoplasmic localization of the
            dioxin (aryl hydrocarbon) receptor
  JOURNAL   J. Biol. Chem. 277 (35), 32310-32319 (2002)
   PUBMED   12065584
  REMARK    GeneRIF: Two parallel pathways mediate cytoplasmic localization
REFERENCE   23 (bases 1 to 5496)
  AUTHORS   Rushing,S.R. and Denison,M.S.
  TITLE     The silencing mediator of retinoic acid and thyroid hormone
            receptors can interact with the aryl hydrocarbon (Ah) receptor but
            fails to repress Ah receptor-dependent gene expression
  JOURNAL   Arch. Biochem. Biophys. 403 (2), 189-201 (2002)
   PUBMED   12139968
  REMARK    GeneRIF: The silencing mediator of retinoic acid and thyroid
            hormone receptors can interact with the aryl hydrocarbon (Ah)
            receptor but fails to repress Ah receptor-dependent gene
            expression.
REFERENCE   24 (bases 1 to 5496)
  AUTHORS   Beischlag,T.V., Wang,S., Rose,D.W., Torchia,J., Reisz-Porszasz,S.,
            Muhammad,K., Nelson,W.E., Probst,M.R., Rosenfeld,M.G. and
            Hankinson,O.
  TITLE     Recruitment of the NCoA/SRC-1/p160 family of transcriptional
            coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon
            receptor nuclear translocator complex
  JOURNAL   Mol. Cell. Biol. 22 (12), 4319-4333 (2002)
   PUBMED   12024042
  REMARK    GeneRIF: SRC-1, NCoA-2, and p/CIP are capable of independently
            enhancing TCDD-dependent induction of a luciferase reporter gene by
            the AHR/ARNT dimer.
REFERENCE   25 (bases 1 to 5496)
  AUTHORS   Wang,S. and Hankinson,O.
  TITLE     Functional involvement of the Brahma/SWI2-related gene 1 protein in
            cytochrome P4501A1 transcription mediated by the aryl hydrocarbon
            receptor complex
  JOURNAL   J. Biol. Chem. 277 (14), 11821-11827 (2002)
   PUBMED   11805098
  REMARK    GeneRIF: Functional involvement of the Brahma/SWI2-related gene 1
            protein in cytochrome P4501A1 transcription mediated by the aryl
            hydrocarbon receptor complex
REFERENCE   26 (bases 1 to 5496)
  AUTHORS   Karchner,S.I., Franks,D.G., Powell,W.H. and Hahn,M.E.
  TITLE     Regulatory interactions among three members of the vertebrate aryl
            hydrocarbon receptor family: AHR repressor, AHR1, and AHR2
  JOURNAL   J. Biol. Chem. 277 (9), 6949-6959 (2002)
   PUBMED   11742002
  REMARK    GeneRIF: Phylogenetic analysis shows that AHRR, AHR1, and AHR2 are
            distinct genes, members of an AHR gene family; these three
            vertebrate AHR-like genes descended from a single invertebrate AHR
REFERENCE   27 (bases 1 to 5496)
  AUTHORS   Fujita,H., Kosaki,R., Yoshihashi,H., Ogata,T., Tomita,M.,
            Hasegawa,T., Takahashi,T., Matsuo,N. and Kosaki,K.
  TITLE     Characterization of the aryl hydrocarbon receptor repressor gene
            and association of its Pro185Ala polymorphism with micropenis
  JOURNAL   Teratology 65 (1), 10-18 (2002)
   PUBMED   11835227
  REMARK    GeneRIF: Arg554Lys was investigated and no association with
            micropenis was found.
REFERENCE   28 (bases 1 to 5496)
  AUTHORS   Khorram,O., Garthwaite,M. and Golos,T.
  TITLE     Uterine and ovarian aryl hydrocarbon receptor (AHR) and aryl
            hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in
            benign and malignant gynaecological conditions
  JOURNAL   Mol. Hum. Reprod. 8 (1), 75-80 (2002)
   PUBMED   11756572
  REMARK    GeneRIF: The female reproductive tract expresses AHR and ARNT mRNA,
            and changes in expression at target sites in conditions such as
            endometriosis and uterine leiomyomas suggest a potential role for
            these factors in the pathogenesis of these conditions.
REFERENCE   29 (bases 1 to 5496)
  AUTHORS   Wong,J.M., Okey,A.B. and Harper,P.A.
  TITLE     Human aryl hydrocarbon receptor polymorphisms that result in loss
            of CYP1A1 induction
  JOURNAL   Biochem. Biophys. Res. Commun. 288 (4), 990-996 (2001)
   PUBMED   11689007
  REMARK    GeneRIF: polymorphisms that result in loss of CYP1A1 induction
REFERENCE   30 (bases 1 to 5496)
  AUTHORS   Komura,K., Hayashi,S., Makino,I., Poellinger,L. and Tanaka,H.
  TITLE     Aryl hydrocarbon receptor/dioxin receptor in human monocytes and
            macrophages
  JOURNAL   Mol. Cell. Biochem. 226 (1-2), 107-118 (2001)
   PUBMED   11768231
  REMARK    GeneRIF: Aryl hydrocarbon receptor/dioxin receptor in human
            monocytes and macrophages
REFERENCE   31 (bases 1 to 5496)
  AUTHORS   Safe,S., Wormke,M. and Samudio,I.
  TITLE     Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen
            receptor crosstalk in human breast cancer cells
  JOURNAL   J Mammary Gland Biol Neoplasia 5 (3), 295-306 (2000)
   PUBMED   14973392
  REMARK    GeneRIF: interactions between the aryl hydrocarbon receptor and
            estrogen receptor have a role in development of breast neoplasms
            [review]
REFERENCE   32 (bases 1 to 5496)
  AUTHORS   Nguyen,T.A., Hoivik,D., Lee,J.E. and Safe,S.
  TITLE     Interactions of nuclear receptor coactivator/corepressor proteins
            with the aryl hydrocarbon receptor complex
  JOURNAL   Arch. Biochem. Biophys. 367 (2), 250-257 (1999)
   PUBMED   10395741
REFERENCE   33 (bases 1 to 5496)
  AUTHORS   Hahn,M.E.
  TITLE     The aryl hydrocarbon receptor: a comparative perspective
  JOURNAL   Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 121
            (1-3), 23-53 (1998)
   PUBMED   9972449
REFERENCE   34 (bases 1 to 5496)
  AUTHORS   Micka,J., Milatovich,A., Menon,A., Grabowski,G.A., Puga,A. and
            Nebert,D.W.
  TITLE     Human Ah receptor (AHR) gene: localization to 7p15 and suggestive
            correlation of polymorphism with CYP1A1 inducibility
  JOURNAL   Pharmacogenetics 7 (2), 95-101 (1997)
   PUBMED   9170146
REFERENCE   35 (bases 1 to 5496)
  AUTHORS   Ema,M., Ohe,N., Suzuki,M., Mimura,J., Sogawa,K., Ikawa,S. and
            Fujii-Kuriyama,Y.
  TITLE     Dioxin binding activities of polymorphic forms of mouse and human
            arylhydrocarbon receptors
  JOURNAL   J. Biol. Chem. 269 (44), 27337-27343 (1994)
   PUBMED   7961644
REFERENCE   36 (bases 1 to 5496)
  AUTHORS   Ema,M., Matsushita,N., Sogawa,K., Ariyama,T., Inazawa,J.,
            Nemoto,T., Ota,M., Oshimura,M. and Fujii-Kuriyama,Y.
  TITLE     Human arylhydrocarbon receptor: functional expression and
            chromosomal assignment to 7p21
  JOURNAL   J. Biochem. 116 (4), 845-851 (1994)
   PUBMED   7883760
REFERENCE   37 (bases 1 to 5496)
  AUTHORS   Eguchi,H., Hayashi,S., Watanabe,J., Gotoh,O. and Kawajiri,K.
  TITLE     Molecular cloning of the human AH receptor gene promoter
  JOURNAL   Biochem. Biophys. Res. Commun. 203 (1), 615-622 (1994)
   PUBMED   8074712
REFERENCE   38 (bases 1 to 5496)
  AUTHORS   Hayashi,S., Watanabe,J., Nakachi,K., Eguchi,H., Gotoh,O. and
            Kawajiri,K.
  TITLE     Interindividual difference in expression of human Ah receptor and
            related P450 genes
  JOURNAL   Carcinogenesis 15 (5), 801-806 (1994)
   PUBMED   7515333
REFERENCE   39 (bases 1 to 5496)
  AUTHORS   Le Beau,M.M., Carver,L.A., Espinosa,R. III, Schmidt,J.V. and
            Bradfield,C.A.
  TITLE     Chromosomal localization of the human AHR locus encoding the
            structural gene for the Ah receptor to 7p21-->p15
  JOURNAL   Cytogenet. Cell Genet. 66 (3), 172-176 (1994)
   PUBMED   8125016
REFERENCE   40 (bases 1 to 5496)
  AUTHORS   Dolwick,K.M., Schmidt,J.V., Carver,L.A., Swanson,H.I. and
            Bradfield,C.A.
  TITLE     Cloning and expression of a human Ah receptor cDNA
  JOURNAL   Mol. Pharmacol. 44 (5), 911-917 (1993)
   PUBMED   8246913
REFERENCE   41 (bases 1 to 5496)
  AUTHORS   Itoh,S. and Kamataki,T.
  TITLE     Human Ah receptor cDNA: analysis for highly conserved sequences
  JOURNAL   Nucleic Acids Res. 21 (15), 3578 (1993)
   PUBMED   8393992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L19872.1 and D31708.1.
            On Jun 8, 1999 this sequence version replaced gi:4502002.
            
            Summary:  Aryl hydrocarbon receptor is a ligand-activated
            transcription factor involved in the regulation of biological
            responses to planar aromatic hydrocarbons.  AHR has been shown to
            regulate xenobiotic-metabolizing enzymes such as cytochrome P450.
            AHR ligands included a variety of aromatic hydrocarbons.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15"
     gene            1..5496
                     /gene="AHR"
                     /db_xref="GeneID:196"
                     /db_xref="MIM:600253"
     misc_feature    29
                     /gene="AHR"
                     /standard_name="alternative 5' end"
                     /evidence=experimental
     CDS             644..3190
                     /gene="AHR"
                     /note="go_component: nucleus [goid 0005634] [evidence IDA]
                     [pmid 10395741];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence NAS] [pmid 9170146];
                     go_function: ligand-dependent nuclear receptor activity
                     [goid 0004879] [evidence IDA] [pmid 10395741];
                     go_process: apoptosis [goid 0006915] [evidence TAS] [pmid
                     12213388];
                     go_process: cell cycle [goid 0007049] [evidence TAS] [pmid
                     12213388];
                     go_process: signal transduction [goid 0007165] [evidence
                     IEA];
                     go_process: response to stress [goid 0006950] [evidence
                     IDA] [pmid 7961644];
                     go_process: response to xenobiotic stimulus [goid 0009410]
                     [evidence IDA] [pmid 7961644];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence IDA] [pmid 10395741];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IDA] [pmid 10395741]"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor"
                     /protein_id="NP_001612.1"
                     /db_xref="GI:4502003"
                     /db_xref="GeneID:196"
                     /db_xref="MIM:600253"
                     /translation="MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLN
                     TELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCR
                     AANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYE
                     LIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMER
                     CFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPS
                     ILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCA
                     ESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGT
                     EHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDS
                     LNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTI
                     LKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDF
                     SGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQ
                     HHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGIS
                     QEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVT
                     CLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTHVGQMQYNPVLPGQQAF
                     LNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGFL"
     polyA_signal    5478..5483
                     /gene="AHR"
ORIGIN      
        1 attcagccgg tgcgcgcggc ggcgggaggc agtggctggg gagtcccgtc gacgctctgt
       61 tccgagagcg tgccccggac cgccagctca gaacaggggc agccgtgtag ccgaacggaa
      121 gctgggagca gccgggactg gtggcccgcg cccgagctcc gcaggcggga agcaccctgg
      181 atttgggaag tcccgggagc agcgcggcgg cacctccctc acccaagggg ccgcggcgac
      241 ggtcacgggg cgcggcgcca ccgtgagcga cccaggccag gattctaaat agacggccca
      301 ggctcctcct ccgcccgggc cgcctcacct gcgggcattg ccgcgccgcc tccgccggtg
      361 tagacggcac ctgcgccgcc ttgctcgcgg gtctccgccc ctcgcccacc ctcactgcgc
      421 caggcccagg cagctcacct gtactggcgc gggctgcgga agcctgcgtg agccgaggcg
      481 ttgaggcgcg gcgcccacgc cactgtcccg agaggacgca ggtggagcgg gcgcggcttc
      541 gcggaacccg gcgccggccg ccgcagtggt cccagcctac accgggttcc ggggacccgg
      601 ccgccagtgc ccggggagta gccgccgccg tcggctgggc accatgaaca gcagcagcgc
      661 caacatcacc tacgccagtc gcaagcggcg gaagccggtg cagaaaacag taaagccaat
      721 cccagctgaa ggaatcaagt caaatccttc caagcggcat agagaccgac ttaatacaga
      781 gttggaccgt ttggctagcc tgctgccttt cccacaagat gttattaata agttggacaa
      841 actttcagtt cttaggctca gcgtcagtta cctgagagcc aagagcttct ttgatgttgc
      901 attaaaatcc tcccctactg aaagaaacgg aggccaggat aactgtagag cagcaaattt
      961 cagagaaggc ctgaacttac aagaaggaga attcttatta caggctctga atggctttgt
     1021 attagttgtc actacagatg ctttggtctt ttatgcttct tctactatac aagattatct
     1081 agggtttcag cagtctgatg tcatacatca gagtgtatat gaacttatcc ataccgaaga
     1141 ccgagctgaa tttcagcgtc agctacactg ggcattaaat ccttctcagt gtacagagtc
     1201 tggacaagga attgaagaag ccactggtct cccccagaca gtagtctgtt ataacccaga
     1261 ccagattcct ccagaaaact ctcctttaat ggagaggtgc ttcatatgtc gtctaaggtg
     1321 tctgctggat aattcatctg gttttctggc aatgaatttc caagggaagt taaagtatct
     1381 tcatggacag aaaaagaaag ggaaagatgg atcaatactt ccacctcagt tggctttgtt
     1441 tgcgatagct actccacttc agccaccatc catacttgaa atccggacca aaaattttat
     1501 ctttagaacc aaacacaaac tagacttcac acctattggt tgtgatgcca aaggaagaat
     1561 tgttttagga tatactgaag cagagctgtg cacgagaggc tcaggttatc agtttattca
     1621 tgcagctgat atgctttatt gtgccgagtc ccatatccga atgattaaga ctggagaaag
     1681 tggcatgata gttttccggc ttcttacaaa aaacaaccga tggacttggg tccagtctaa
     1741 tgcacgcctg ctttataaaa atggaagacc agattatatc attgtaactc agagaccact
     1801 aacagatgag gaaggaacag agcatttacg aaaacgaaat acgaagttgc cttttatgtt
     1861 taccactgga gaagctgtgt tgtatgaggc aaccaaccct tttcctgcca taatggatcc
     1921 cttaccacta aggactaaaa atggcactag tggaaaagac tctgctacca catccactct
     1981 aagcaaggac tctctcaatc ctagttccct cctggctgcc atgatgcaac aagatgagtc
     2041 tatttatctc tatcctgctt caagtacttc aagtactgca ccttttgaaa acaacttttt
     2101 caacgaatct atgaatgaat gcagaaattg gcaagataat actgcaccga tgggaaatga
     2161 tactatcctg aaacatgagc aaattgacca gcctcaggat gtgaactcat ttgctggagg
     2221 tcacccaggg ctctttcaag atagtaaaaa cagtgacttg tacagcataa tgaaaaacct
     2281 aggcattgat tttgaagaca tcagacacat gcagaatgaa aaatttttca gaaatgattt
     2341 ttctggtgag gttgacttca gagacattga cttaacggat gaaatcctga cgtatgtcca
     2401 agattcttta agtaagtctc ccttcatacc ttcagattat caacagcaac agtccttggc
     2461 tctgaactca agctgtatgg tacaggaaca cctacatcta gaacagcaac agcaacatca
     2521 ccaaaagcaa gtagtagtgg agccacagca acagctgtgt cagaagatga agcacatgca
     2581 agttaatggc atgtttgaaa attggaactc taaccaattc gtgcctttca attgtccaca
     2641 gcaagaccca caacaatata atgtctttac agacttacat gggatcagtc aagagttccc
     2701 ctacaaatct gaaatggatt ctatgcctta tacacagaac tttatttcct gtaatcagcc
     2761 tgtattacca caacattcca aatgtacaga gctggactac cctatgggga gttttgaacc
     2821 atccccatac cccactactt ctagtttaga agattttgtc acttgtttac aacttcctga
     2881 aaaccaaaag catggattaa atccacagtc agccataata actcctcaga catgttatgc
     2941 tggggccgtg tcgatgtatc agtgccagcc agaacctcag cacacccacg tgggtcagat
     3001 gcagtacaat ccagtactgc caggccaaca ggcattttta aacaagtttc agaatggagt
     3061 tttaaatgaa acatatccag ctgaattaaa taacataaat aacactcaga ctaccacaca
     3121 tcttcagcca cttcatcatc cgtcagaagc cagacctttt cctgatttga catccagtgg
     3181 attcctgtaa ttccaagccc aattttgacc ctggtttttg gattaaatta gtttgtgaag
     3241 gattatggaa aaataaaact gtcactgttg gacgtcagca agttcacatg gaggcattga
     3301 tgcatgctat tcacaattat tccaaaccaa attttaattt ttgcttttag aaaagggagt
     3361 ttaaaaatgg tatcaaaatt acatatacta cagtcaagat agaaagggtg ctgccacgga
     3421 gtggtgaggt accgtctaca tttcacatta ttctgggcac cacaaaatat acaaaacttt
     3481 atcagggaaa ctaagattct tttaaattag aaaatattct ctatttgaat tatttctgtc
     3541 acagtaaaaa taaaatactt tgagttttga gctactggat tcttattagt tccccaaata
     3601 caaagttaga gaactaaact agtttttcct atcatgttaa cctctgcttt tatctcagat
     3661 gttaaaataa atggtttggt gctttttata aaaagataat ctcagtgctt tcctccttca
     3721 ctgtttcatc taagtgcctc acattttttt ctacctataa cactctagga tgtatatttt
     3781 atataaagta ttctttttct tttttaaatt aatatctttc tgcacacaaa tattatttgt
     3841 gtttcctaaa tccaaccaat tttcattaat tcaggcatat tttaactcca ctgcttacct
     3901 actttcttca ggtaaaaggg caaataatga tcgaaaaaat aattatttat tacataattt
     3961 agttgtttct agactataaa tgttgctatg tgccttatgt tgaaaaaatt taaaagtaaa
     4021 atgtctttcc aaattatttc ttaattatta taaaaatatt aagacaatag cacttaaatt
     4081 cctcaacagt gttttcagaa gaaataaata taccactctt tacctttatt gatatctcca
     4141 tgatgatagt tgaatgttgc aatgtgaaaa atctgctgtt aactgcaacc ttgtttatta
     4201 aattgcaaga agctttattt ctagcttttt aattaagcaa agcacccatt tcaatgtgta
     4261 taaattgtct ttaaaaactg ttttagacct ataatccttg ataatatatt gtgttgactt
     4321 tataaatttc gcttcttaga acagtggaaa ctatgtgttt ttctcatatt tgaggagtgt
     4381 taagattgca gatagcaagg tttggtgcaa agtattgtaa tgagtgaatt gaatggtgca
     4441 ttgtatagat ataatgaaca aaattatttg taagatattt gcagtttttc attttaaaaa
     4501 gtccatacct tatatatgca cttaatttgt tggggcttta catactttat caatgtgtct
     4561 ttctaagaaa tcaagtaatg aatccaactg cttaaagttg gtattaataa aaagacaacc
     4621 acatagttcg tttaccttca aactttaggt ttttttaatg atatactgat cttcattacc
     4681 aataggcaaa ttaatcaccc taccaacttt actgtcctaa catggacttt caaaaagaaa
     4741 aaatgacacc atcttttatt cttttttttt tttttttttt gagagagagt cttactctgc
     4801 cgcccaaact ggagtgcagt ggcacaatct tggctcactg caacctctac ctcctgggtt
     4861 caagtgattc tcttgcctca gcctcccgag ttgctgggat tgcgggcatg gtggcgtgag
     4921 cctgtagtcc tagctactcg ggaggctgag gcaggagaat agcctgaacc tgggaatcgg
     4981 aggttgcagg gccaagatcg ccccactgca ctccagcctg gcaatagacc gagctccgtc
     5041 tccaaaaaaa aaaatacaat ttttatttct tttacttttt ttagtaagtt aatgtatata
     5101 aaaatggctt cggacaaaat atctctgagt tctgtgtatt ttcagtcaaa actttaaacc
     5161 tgtagaatca atttaagtgt tgaaaaaaat ttgtctgaaa catttcataa tttgtttcca
     5221 gcatgaggta tctaaggatt tagaccagag gtctagatta atactctatt tttacattta
     5281 aaccttttat tataagtctt acataaacca tttttgttac tctcttccac atgttactgg
     5341 ataaattgtt tagtggaaaa taggcttttt aatcatgaat atgatgacaa tcagttatac
     5401 agttataaaa ttaaaagttt gaaaagcaat attgtatatt tttatctata taaaataact
     5461 aaaatgtatc taagaataat aaaatcacgt taaacc
//

LOCUS       NM_001630               1940 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens annexin A8 (ANXA8), mRNA.
ACCESSION   NM_001630
VERSION     NM_001630.1  GI:4502112
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Sarkar,A., Yang,P., Fan,Y.H., Mu,Z.M., Hauptmann,R., Adolf,G.R.,
            Stass,S.A. and Chang,K.S.
  TITLE     Regulation of the expression of annexin VIII in acute promyelocytic
            leukemia
  JOURNAL   Blood 84 (1), 279-286 (1994)
  MEDLINE   94289712
   PUBMED   8018923
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Chambers,J.A., Gardner,E., Hauptmann,R., Ponder,B.A. and
            Mulligan,L.M.
  TITLE     TaqI polymorphisms at the annexin VIII locus (ANX8)
  JOURNAL   Hum. Mol. Genet. 1 (7), 550 (1992)
  MEDLINE   93338455
   PUBMED   1364010
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Chang,K.S., Wang,G., Freireich,E.J., Daly,M., Naylor,S.L.,
            Trujillo,J.M. and Stass,S.A.
  TITLE     Specific expression of the annexin VIII gene in acute promyelocytic
            leukemia
  JOURNAL   Blood 79 (7), 1802-1810 (1992)
  MEDLINE   92216091
   PUBMED   1313714
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Hauptmann,R., Maurer-Fogy,I., Krystek,E., Bodo,G., Andree,H. and
            Reutelingsperger,C.P.
  TITLE     Vascular anticoagulant beta: a novel human Ca2+/phospholipid
            binding protein that inhibits coagulation and phospholipase A2
            activity. Its molecular cloning, expression and comparison with
            VAC-alpha
  JOURNAL   Eur. J. Biochem. 185 (1), 63-71 (1989)
  MEDLINE   90032687
   PUBMED   2530088
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X16662.1.
            
            Summary:  Annexin VIII belong to the family of Ca (2+) dependent
            phospholipid binding proteins (annexins), and has a high 56%
            identity to annexin V (vascular anticoagulant-alpha).  It was
            initially isolated as 2.2 kb vascular anticoagulant-beta transcript
            from human placenta, a Ca (2+) dependent phospholipid binding
            protein that inhibits coagulation and phospholipase A2 activity.
            However, the fact that annexin VIII is neither an extracellular
            protein nor associated with the cell surface suggests that it may
            not play a role in blood coagulation in vivo and its physiological
            role  remains unknown.  It is expressed at low levels in human
            placenta and shows restricted expression in lung endothelia, skin,
            liver, and kidney. The gene is also found to be selectively
            overexpressed in acute myelocytic leukemia.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.2"
     gene            1..1940
                     /gene="ANXA8"
                     /note="synonyms: ANX8, ANXA8L2"
                     /db_xref="GeneID:244"
                     /db_xref="MIM:602396"
     CDS             107..1090
                     /gene="ANXA8"
                     /note="vascular anticoagculant-beta; Annexin VII; annexin
                     VIII; annexin A8-like 2;
                     go_function: calcium ion binding [goid 0005509] [evidence
                     NR];
                     go_function: calcium-dependent phospholipid binding [goid
                     0005544] [evidence IEA];
                     go_process: blood coagulation [goid 0007596] [evidence
                     IEA];
                     go_process: negative regulation of coagulation [goid
                     0050819] [evidence IEA]"
                     /codon_start=1
                     /product="annexin A8"
                     /protein_id="NP_001621.1"
                     /db_xref="GI:4502113"
                     /db_xref="GeneID:244"
                     /db_xref="MIM:602396"
                     /translation="MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAI
                     IDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKEL
                     HDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILV
                     CLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFE
                     EYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTL
                     IRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP"
     polyA_signal    1919..1924
                     /gene="ANXA8"
     polyA_site      1940
                     /gene="ANXA8"
ORIGIN      
        1 aggcctgctc actcctcagc tgcaggagcc agacgtgtgg agtcccagca gaggccaacc
       61 tgtgtctctt catctccgtg agaaaggtgc ccccgaagtg aaagagatgg cctggtggaa
      121 agcctggatt gaacaggagg gtgtcacagt gaagagcagc tcccacttca acccagaccc
      181 tgatgcagag accctctaca aagccatgaa ggggatcggg accaacgagc aggctatcat
      241 cgatgtgctc accaagagaa gcaacacgca gcggcagcag atcgccaagt ccttcaaggc
      301 tcagttcggc aaggacctca ctgagacctt gaagtctgag ctcagtggca agtttgagag
      361 gctcattgtg gcccttatgt atccgccata cagatacgaa gccaaggagc tgcatgacgc
      421 catgaagggc ttaggaacca aggagggtgt catcattgag atcctggcct ctcggaccaa
      481 gaaccagctg cgggagataa tgaaggcgta tgaggaagac tatgggtcca gcctggagga
      541 ggacatccaa gcagacacaa gtggctacct ggagaggatc ctggtgtgcc tcctgcaggg
      601 cagcagggat gatgtgagca gctttgtgga cccggcactg gccctccaag acgcacagga
      661 tctgtatgcg gcaggcgaga agattcgtgg gactgatgag atgaaattca tcaccatcct
      721 gtgcacgcgc agtgccactc acctgctgag agtgtttgaa gagtatgaga aaattgccaa
      781 caagagcatt gaggacagca tcaagagtga gacccatggc tcactggagg aggccatgct
      841 cactgtggtg aaatgcaccc aaaacctcca cagctacttt gcagagagac tctactatgc
      901 catgaaggga gcagggacgc gtgatgggac cctgataaga aacatcgttt caaggagcga
      961 gattgactta aatcttatca aatgtcactt caagaagatg tacggcaaga ccctcagcag
     1021 catgatcatg gaagacacca gcggcgacta caagaacgcc ctgctgagcc tggtgggcag
     1081 cgacccctga ggcacagaag aacaagagca aagaccatga agccagagtc tccaggactc
     1141 ctcactcaac ctcggccatg gacgcaggtt gggtgtgagg ggggtcccag cctttcggtc
     1201 ttctatttcc ctatttccag tgctttccag ccgggtttct gacccagagg tggaaccggc
     1261 ctggactcct cttcccaact tcctccaggt catttcccag tgtgagcaca atgccaacct
     1321 tagtgtttct ccagccagac agatgcctca gcatgaaggg cttggggact tgtggatcat
     1381 tccttcctcc ctgcaggagc ttcccaagct ggtcacagag tctcctgggc acaggttata
     1441 cagaccccag ccccattccc atctactgaa acagggtctc cacaagaggg gccagggaat
     1501 atgggttttt aacaagcgtc ttacaaaaca cttctctatc atgcagccgg agagctggct
     1561 gggagccctt ttgttttaga acacacatcc ttcagcagct gagaaatgaa cacgaatcca
     1621 tcccaaccga gatgccatta acattcatct aaaaatgtta ggctctaaat ggacgaaaaa
     1681 ttctctcgcc atcttaataa caaaataaac tacaaattcc tgacccaagg acactgtgtt
     1741 ataagaggcg tgggctcccc tggtggctga ccaggtcagc tgccctggcc ttgcacccct
     1801 ctgcatgcag cacagaaggg tgtgaccatg ccctcagcac cactcttgtc cccactgaac
     1861 ggcaactgag actgggtacc tggagattct gaagtgcctt tgctgtggtt ttcaaaataa
     1921 taaagatttg tattcaactc
//

LOCUS       NM_001654               2466 bp    mRNA    linear   PRI 23-JAN-2005
DEFINITION  Homo sapiens v-raf murine sarcoma 3611 viral oncogene homolog
            (ARAF), mRNA.
ACCESSION   NM_001654
VERSION     NM_001654.1  GI:4502192
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Frans, Klinten, Osterstr, Dimberg,J., Monstein,H.J. and S.
  TITLE     Mutation analysis of the BRAF, ARAF and RAF-1 genes in human
            colorectal adenocarcinomas
  JOURNAL   Carcinogenesis 25 (4), 527-533 (2004)
   PUBMED   14688025
  REMARK    GeneRIF: mutation analysis of the conserved regions in the ARAF
            gene in human colorectal adenocarcinoma
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Liu,W., Shen,X., Yang,Y., Yin,X., Xie,J., Yan,J., Jiang,J., Liu,W.,
            Wang,H., Sun,M., Zheng,Y. and Gu,J.
  TITLE     Trihydrophobin 1 is a new negative regulator of A-Raf kinase
  JOURNAL   J. Biol. Chem. 279 (11), 10167-10175 (2004)
   PUBMED   14684750
  REMARK    GeneRIF: A-Raf kinase is negatively regulated by trihydrophobin 1
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Yin,X.L., Chen,S. and Gu,J.X.
  TITLE     Identification of TH1 as an interaction partner of A-Raf kinase
  JOURNAL   Mol. Cell. Biochem. 231 (1-2), 69-74 (2002)
  MEDLINE   21948648
   PUBMED   11952167
  REMARK    GeneRIF: In a two-hybrid screen of human fetal liver cDNA library,
            TH1 was detected as a new interaction partner of A-Raf; this
            specific interaction may have played a critical role in the
            activation of A-Raf.
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Wu,X., Noh,S.J., Zhou,G., Dixon,J.E. and Guan,K.L.
  TITLE     Selective activation of MEK1 but not MEK2 by A-Raf from epidermal
            growth factor-stimulated Hela cells
  JOURNAL   J. Biol. Chem. 271 (6), 3265-3271 (1996)
  MEDLINE   96216407
   PUBMED   8621729
  REMARK    GeneRIF: A-Raf interacts with MEK1 and activates MEK1 by
            phosphorylation.
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Lee,J.E., Beck,T.W., Brennscheidt,U., DeGennaro,L.J. and Rapp,U.R.
  TITLE     The complete sequence and promoter activity of the human A-raf-1
            gene (ARAF1)
  JOURNAL   Genomics 20 (1), 43-55 (1994)
  MEDLINE   94292185
   PUBMED   8020955
REFERENCE   6  (bases 1 to 2466)
  AUTHORS   Popescu,N.C. and Mark,G.E.
  TITLE     Localization of the pKs gene, a raf related sequence on human
            chromosomes X and 7
  JOURNAL   Oncogene 4 (4), 517-519 (1989)
  MEDLINE   89239480
   PUBMED   2717185
REFERENCE   7  (bases 1 to 2466)
  AUTHORS   Beck,T.W., Huleihel,M., Gunnell,M., Bonner,T.I. and Rapp,U.R.
  TITLE     The complete coding sequence of the human A-raf-1 oncogene and
            transforming activity of a human A-raf carrying retrovirus
  JOURNAL   Nucleic Acids Res. 15 (2), 595-609 (1987)
  MEDLINE   87146380
   PUBMED   3029685
REFERENCE   8  (bases 1 to 2466)
  AUTHORS   Mark,G.E., Seeley,T.W., Shows,T.B. and Mountz,J.D.
  TITLE     Pks, a raf-related sequence in humans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (17), 6312-6316 (1986)
  MEDLINE   86313571
   PUBMED   3529082
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L24038.1.
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4-p11.2"
     gene            1..2466
                     /gene="ARAF"
                     /note="synonyms: PKS2, A-RAF, ARAF1, RAFA1"
                     /db_xref="GeneID:369"
                     /db_xref="MIM:311010"
     CDS             203..2023
                     /gene="ARAF"
                     /EC_number="2.7.1.-"
                     /note="Oncogene ARAF1; v-raf murine sarcoma 3611 viral
                     oncogene homolog 1;
                     go_component: cellular_component unknown [goid 0008372]
                     [evidence ND];
                     go_function: ATP binding [goid 0005524] [evidence NAS];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: diacylglycerol binding [goid 0019992]
                     [evidence IEA];
                     go_function: receptor signaling protein activity [goid
                     0005057] [evidence IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence NAS];
                     go_process: intracellular signaling cascade [goid 0007242]
                     [evidence IEA];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence NAS]"
                     /codon_start=1
                     /product="v-raf murine sarcoma 3611 viral oncogene
                     homolog"
                     /protein_id="NP_001645.1"
                     /db_xref="GI:4502193"
                     /db_xref="GeneID:369"
                     /db_xref="MIM:311010"
                     /translation="MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDS
                     LDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFV
                     RKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQD
                     LSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNV
                     HMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPA
                     EQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVA
                     VKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYH
                     HLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
                     ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLP
                     YSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILAT
                     IELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP"
ORIGIN      
        1 acgtgaccct gacccaataa gggtggaagg ctgagtccgc agagccaata acgagagtcc
       61 gagaggcgac ggaggcggac tctgtgagga aacaagaaga gaggcccaag atggagacgg
      121 cggcggctgt agcggcgtga caggagcccc atggcacctg cccagcccca cctcagccca
      181 tcttgacaaa atctaaggct ccatggagcc accacggggc ccccctgcca atggggccga
      241 gccatcccgg gcagtgggca ccgtcaaagt atacctgccc aacaagcaac gcacggtggt
      301 gactgtccgg gatggcatga gtgtctacga ctctctagac aaggccctga aggtgcgggg
      361 tctaaatcag gactgctgtg tggtctaccg actcatcaag ggacgaaaga cggtcactgc
      421 ctgggacaca gccattgctc ccctggatgg cgaggagctc attgtcgagg tccttgaaga
      481 tgtcccgctg accatgcaca attttgtacg gaagaccttc ttcagcctgg cgttctgtga
      541 cttctgcctt aagtttctgt tccatggctt ccgttgccaa acctgtggct acaagttcca
      601 ccagcattgt tcctccaagg tccccacagt ctgtgttgac atgagtacca accgccaaca
      661 gttctaccac agtgtccagg atttgtccgg aggctccaga cagcatgagg ctccctcgaa
      721 ccgccccctg aatgagttgc taacccccca gggtcccagc ccccgcaccc agcactgtga
      781 cccggagcac ttccccttcc ctgccccagc caatgccccc ctacagcgca tccgctccac
      841 gtccactccc aacgtccata tggtcagcac cacggccccc atggactcca acctcatcca
      901 gctcactggc cagagtttca gcactgatgc tgccggtagt agaggaggta gtgatggaac
      961 cccccggggg agccccagcc cagccagcgt gtcctcgggg aggaagtccc cacattccaa
     1021 gtcaccagca gagcagcgcg agcggaagtc cttggccgat gacaagaaga aagtgaagaa
     1081 cctggggtac cgggactcag gctattactg ggaggtacca cccagtgagg tgcagctgct
     1141 gaagaggatc gggacgggct cgtttggcac cgtgtttcga gggcggtggc atggcgatgt
     1201 ggccgtgaag gtgctcaagg tgtcccagcc cacagctgag caggcccagg ctttcaagaa
     1261 tgagatgcag gtgctcagga agacgcgaca tgtcaacatc ttgctgttta tgggcttcat
     1321 gacccggccg ggatttgcca tcatcacaca gtggtgtgag ggctccagcc tctaccatca
     1381 cctgcatgtg gccgacacac gcttcgacat ggtccagctc atcgacgtgg cccggcagac
     1441 tgcccagggc atggactacc tccatgccaa gaacatcatc caccgagatc tcaagtctaa
     1501 caacatcttc ctacatgagg ggctcacggt gaagatcggt gactttggct tggccacagt
     1561 gaagactcga tggagcgggg cccagccctt ggagcagccc tcaggatctg tgctgtggat
     1621 ggcagctgag gtgatccgta tgcaggaccc gaacccctac agcttccagt cagacgtcta
     1681 tgcctacggg gttgtgctct acgagcttat gactggctca ctgccttaca gccacattgg
     1741 ctgccgtgac cagattatct ttatggtggg ccgtggctat ctgtccccgg acctcagcaa
     1801 aatctccagc aactgcccca aggccatgcg gcgcctgctg tctgactgcc tcaagttcca
     1861 gcgggaggag cggcccctct tcccccagat cctggccaca attgagctgc tgcaacggtc
     1921 actccccaag attgagcgga gtgcctcgga accctccttg caccgcaccc aggccgatga
     1981 gttgcctgcc tgcctactca gcgcagcccg ccttgtgcct taggccccgc ccaagccacc
     2041 agggagccaa tctcagccct ccacgccaag gagccttgcc caccagccaa tcaatgttcg
     2101 tctctgccct gatgctgcct caggatcccc cattccccac cctgggagat gagggggtcc
     2161 ccatgtgctt ttccagttct tctggaattg ggggaccccc gccaaagact gagccccctg
     2221 tctcctccat catttggttt cctctttggc tttggggata cttctaaatt ttgggagctc
     2281 ctccatctcc aatggctggg atttgtggca gggattccac tcagaacctc tctggaattt
     2341 gtgcctgatg tgccttccac tggattttgg ggttcccagc accccatgtg gattttgggg
     2401 gtcccttttg tgtctccccc gccattcaag gactcctctc tttcttcacc aagaagcaca
     2461 gaattc
//

LOCUS       NM_001753               2704 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1), mRNA.
ACCESSION   NM_001753
VERSION     NM_001753.3  GI:15451855
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Sloan,E.K., Stanley,K.L. and Anderson,R.L.
  TITLE     Caveolin-1 inhibits breast cancer growth and metastasis
  JOURNAL   Oncogene 23 (47), 7893-7897 (2004)
   PUBMED   15334058
  REMARK    GeneRIF: Caveolin-1 regulates primary breast tumor growth and
            spontaneous metastasis of breast cancer.
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Cho,K.A., Ryu,S.J., Oh,Y.S., Park,J.H., Lee,J.W., Kim,H.P.,
            Kim,K.T., Jang,I.S. and Park,S.C.
  TITLE     Morphological adjustment of senescent cells by modulating
            caveolin-1 status
  JOURNAL   J. Biol. Chem. 279 (40), 42270-42278 (2004)
   PUBMED   15263006
  REMARK    GeneRIF: caveolin-1 plays an important role in
            senescence-associated morphological changes by regulating focal
            adhesion kinase activity and actin stress fiber formation in the
            senescent cells.
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Pang,A., Au,W.Y. and Kwong,Y.L.
  TITLE     Caveolin-1 gene is coordinately regulated with the multidrug
            resistance 1 gene in normal and leukemic bone marrow
  JOURNAL   Leuk. Res. 28 (9), 973-977 (2004)
   PUBMED   15234575
  REMARK    GeneRIF: In four different groups of marrow samples (20 normal, 56
            acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and
            51 regenerating marrows), caveolin-1 and MDR-1 gene expressions
            were positively correlated
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Shatz,M. and Liscovitch,M.
  TITLE     Caveolin-1 and cancer multidrug resistance: coordinate regulation
            of pro-survival proteins?
  JOURNAL   Leuk. Res. 28 (9), 907-908 (2004)
   PUBMED   15234566
  REMARK    GeneRIF: review of coordination of caveolin-1 gene expression
            regulation with that of MDR1 in cancer cells
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Bhatnagar,A., Sheffler,D.J., Kroeze,W.K., Compton-Toth,B. and
            Roth,B.L.
  TITLE     Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly
            modulates the signaling of selected Galphaq-coupled protein
            receptors
  JOURNAL   J. Biol. Chem. 279 (33), 34614-34623 (2004)
   PUBMED   15190056
  REMARK    GeneRIF: Cav-1 has a role in regulating the functional activity of
            5-HT(2A) serotonin receptors and Galpha(q)-coupled receptors
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Cai,C., Zhu,H. and Chen,J.
  TITLE     Overexpression of caveolin-1 increases plasma membrane fluidity and
            reduces P-glycoprotein function in Hs578T/Dox
  JOURNAL   Biochem. Biophys. Res. Commun. 320 (3), 868-874 (2004)
   PUBMED   15240128
  REMARK    GeneRIF: Our data demonstrate for the first time that the reduction
            of the plasma membrane cholesterol level induced by overexpressing
            caveolin-1 may indirectly inhibit P-gp transport activity by
            increasing plasma membrane fluidity.
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Vainonen,J.P., Aboulaich,N., Turkina,M.V., Str and Vener,A.V.
  TITLE     N-terminal processing and modifications of caveolin-1 in caveolae
            from human adipocytes
  JOURNAL   Biochem. Biophys. Res. Commun. 320 (2), 480-486 (2004)
   PUBMED   15219854
  REMARK    GeneRIF: phosphorylation was found in both the acetylated and
            non-acetylated variants of caveolin-1beta. This variability in
            modifications is consistent with critical involvement of the
            N-terminal domain of caveolin in the regulation of caveolae
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Sunaga,N., Miyajima,K., Suzuki,M., Sato,M., White,M.A.,
            Ramirez,R.D., Shay,J.W., Gazdar,A.F. and Minna,J.D.
  TITLE     Different roles for caveolin-1 in the development of non-small cell
            lung cancer versus small cell lung cancer
  JOURNAL   Cancer Res. 64 (12), 4277-4285 (2004)
   PUBMED   15205342
  REMARK    GeneRIF: Results suggest different roles for CAV1 in SCLC, where
            CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears
            required for survival and growth.
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Lin,S.Y., Yeh,K.T., Chen,W.T., Chen,H.C., Chen,S.T. and Chang,J.G.
  TITLE     Promoter CpG methylation of caveolin-1 in sporadic colorectal
            cancer
  JOURNAL   Anticancer Res. 24 (3A), 1645-1650 (2004)
  MEDLINE   23448199
   PUBMED   15274335
  REMARK    GeneRIF: Aberrant promoter methylation of the caveolin-1 gene may
            occur at the precancerous stage, regulated by gender-related
            factors and is associated with gene silencing of caveolin-1 in the
            development of colorectal cancer.
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Patlolla,J.M., Swamy,M.V., Raju,J. and Rao,C.V.
  TITLE     Overexpression of caveolin-1 in experimental colon adenocarcinomas
            and human colon cancer cell lines
  JOURNAL   Oncol. Rep. 11 (5), 957-963 (2004)
   PUBMED   15069532
  REMARK    GeneRIF: caveolin-1 is overexpressed in experimental colon
            adenocarcinoma by comparison to adjacent normal mucosa, and its
            expression in human colon cancer cells is directly associated with
            the growth rate
REFERENCE   11 (bases 1 to 2704)
  AUTHORS   Phillips,P.G. and Birnby,L.M.
  TITLE     Nitric oxide modulates caveolin-1 and matrix metalloproteinase-9
            expression and distribution at the endothelial cell/tumor cell
            interface
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5), L1055-L1065 (2004)
   PUBMED   15064242
  REMARK    GeneRIF: Nitric oxide concentrations could impact on capillary
            formation via a combination of direct effects on MMP activation and
            by altering the distribution or abundance of Cav-1 in tumor
            angiogenesis.
REFERENCE   12 (bases 1 to 2704)
  AUTHORS   Fu,Y., Hoang,A., Escher,G., Parton,R.G., Krozowski,Z. and
            Sviridov,D.
  TITLE     Expression of caveolin-1 enhances cholesterol efflux in hepatic
            cells
  JOURNAL   J. Biol. Chem. 279 (14), 14140-14146 (2004)
   PUBMED   14729661
  REMARK    GeneRIF: overexpression of caveolin-1 in hepatic cells stimulates
            cholesterol efflux by enhancing transfer of cholesterol to
            cholesterol-rich domains in the plasma membrane.
REFERENCE   13 (bases 1 to 2704)
  AUTHORS   Tang,W. and Hemler,M.E.
  TITLE     Caveolin-1 regulates matrix metalloproteinases-1 induction and
            CD147/EMMPRIN cell surface clustering
  JOURNAL   J. Biol. Chem. 279 (12), 11112-11118 (2004)
   PUBMED   14707126
  REMARK    GeneRIF: caveolin-1 associates with CD147, in a complex distinct
            from CD147-alpha(3) integrin complexes, thereby diminishing both
            CD147 clustering and CD147-dependent MMP-1-inducing activity
REFERENCE   14 (bases 1 to 2704)
  AUTHORS   Ge,S. and Pachter,J.S.
  TITLE     Caveolin-1 knockdown by small interfering RNA suppresses responses
            to the chemokine monocyte chemoattractant protein-1 by human
            astrocytes
  JOURNAL   J. Biol. Chem. 279 (8), 6688-6695 (2004)
   PUBMED   14660607
  REMARK    GeneRIF: caveolin-1 has a role in mediating astrocyte responses to
            MCP-1
REFERENCE   15 (bases 1 to 2704)
  AUTHORS   Han,S.E., Park,K.H., Lee,G., Huh,Y.J. and Min,B.M.
  TITLE     Mutation and aberrant expression of Caveolin-1 in human oral
            squamous cell carcinomas and oral cancer cell lines
  JOURNAL   Int. J. Oncol. 24 (2), 435-440 (2004)
   PUBMED   14719121
  REMARK    GeneRIF: inactivation of Caveolin-1 by a mutation or by reduced
            expression may play a role in the pathogenesis of oral cancer
REFERENCE   16 (bases 1 to 2704)
  AUTHORS   Lu,Z., Ghosh,S., Wang,Z. and Hunter,T.
  TITLE     Downregulation of caveolin-1 function by EGF leads to the loss of
            E-cadherin, increased transcriptional activity of beta-catenin, and
            enhanced tumor cell invasion
  JOURNAL   Cancer Cell 4 (6), 499-515 (2003)
   PUBMED   14706341
  REMARK    GeneRIF: negative regulation of caveolin-1 plays a central role in
            the complex cellular changes leading to metastasis
REFERENCE   17 (bases 1 to 2704)
  AUTHORS   Li,L., Ren,C.H., Tahir,S.A., Ren,C. and Thompson,T.C.
  TITLE     Caveolin-1 maintains activated Akt in prostate cancer cells through
            scaffolding domain binding site interactions with and inhibition of
            serine/threonine protein phosphatases PP1 and PP2A
  JOURNAL   Mol. Cell. Biol. 23 (24), 9389-9404 (2003)
   PUBMED   14645548
  REMARK    GeneRIF: Akt activities are largely responsible for cav-1-mediated
            cell survival
REFERENCE   18 (bases 1 to 2704)
  AUTHORS   Campbell,L., Gumbleton,M. and Griffiths,D.F.
  TITLE     Caveolin-1 overexpression predicts poor disease-free survival of
            patients with clinically confined renal cell carcinoma
  JOURNAL   Br. J. Cancer 89 (10), 1909-1913 (2003)
  MEDLINE   22973588
   PUBMED   14612902
  REMARK    GeneRIF: cytoplasmic overexpression of caveolin-1 predicts a poor
            prognosis in renal cell carcinoma
REFERENCE   19 (bases 1 to 2704)
  AUTHORS   Zou,W., McDaneld,L. and Smith,L.M.
  TITLE     Caveolin-1 haploinsufficiency leads to partial transformation of
            human breast epithelial cells
  JOURNAL   Anticancer Res. 23 (6C), 4581-4586 (2003)
  MEDLINE   23155554
   PUBMED   14981899
  REMARK    GeneRIF: Cav-1 haploinsufficiency in human breast epithelial cells
            can lead to partial transformation.
REFERENCE   20 (bases 1 to 2704)
  AUTHORS   Peterson,T.E., Guicciardi,M.E., Gulati,R., Kleppe,L.S.,
            Mueske,C.S., Mookadam,M., Sowa,G., Gores,G.J., Sessa,W.C. and
            Simari,R.D.
  TITLE     Caveolin-1 can regulate vascular smooth muscle cell fate by
            switching platelet-derived growth factor signaling from a
            proliferative to an apoptotic pathway
  JOURNAL   Arterioscler. Thromb. Vasc. Biol. 23 (9), 1521-1527 (2003)
  MEDLINE   22852342
   PUBMED   12816877
  REMARK    GeneRIF: Caveolin-1 is an inhibitor of platelet-derived growth
            factor (PDGF) proliferative responses and might be capable of
            transforming PDGF-induced proliferative signals into death signals.
REFERENCE   21 (bases 1 to 2704)
  AUTHORS   Chan,T.F., Su,T.H., Yeh,K.T., Chang,J.Y., Lin,T.H., Chen,J.C.,
            Yuang,S.S. and Chang,J.G.
  TITLE     Mutational, epigenetic and expressional analyses of caveolin-1 gene
            in cervical cancers
  JOURNAL   Int. J. Oncol. 23 (3), 599-604 (2003)
  MEDLINE   22770213
   PUBMED   12888893
  REMARK    GeneRIF: CAV-1 gene can be inactivated through mutations and does
            not play a role in the development of cervical cancer
REFERENCE   22 (bases 1 to 2704)
  AUTHORS   Cho,K.A., Ryu,S.J., Park,J.S., Jang,I.S., Ahn,J.S., Kim,K.T. and
            Park,S.C.
  TITLE     Senescent phenotype can be reversed by reduction of caveolin status
  JOURNAL   J. Biol. Chem. 278 (30), 27789-27795 (2003)
  MEDLINE   22753794
   PUBMED   12730243
  REMARK    GeneRIF: caveolin has a role in recovery from cell sensecence
REFERENCE   23 (bases 1 to 2704)
  AUTHORS   Brazer,S.C., Singh,B.B., Liu,X., Swaim,W. and Ambudkar,I.S.
  TITLE     Caveolin-1 contributes to assembly of store-operated Ca2+ influx
            channels by regulating plasma membrane localization of TRPC1
  JOURNAL   J. Biol. Chem. 278 (29), 27208-27215 (2003)
  MEDLINE   22741687
   PUBMED   12732636
  REMARK    GeneRIF: Caveolin-1 contributes to assembly of store-operated Ca2+
            influx channels by regulating plasma membrane localization of
            TRPC1.
REFERENCE   24 (bases 1 to 2704)
  AUTHORS   Sasai,K., Ikeda,Y., Ihara,H., Honke,K. and Taniguchi,N.
  TITLE     Caveolin-1 regulates the functional localization of
            N-acetylglucosaminyltransferase III within the golgi apparatus
  JOURNAL   J. Biol. Chem. 278 (28), 25295-25301 (2003)
  MEDLINE   22726714
   PUBMED   12716887
  REMARK    GeneRIF: Caveolin-1 may modify the biosynthetic pathway of sugar
            chains via the regulation of the intra-Golgi subcompartment
            localization of N-acetylglucosaminyltransferase III
REFERENCE   25 (bases 1 to 2704)
  AUTHORS   Burgermeister,E., Tencer,L. and Liscovitch,M.
  TITLE     Peroxisome proliferator-activated receptor-gamma upregulates
            caveolin-1 and caveolin-2 expression in human carcinoma cells
  JOURNAL   Oncogene 22 (25), 3888-3900 (2003)
  MEDLINE   22697650
   PUBMED   12813462
  REMARK    GeneRIF: PPARgamma & caveolin-1 may coexist in a complex. PPARgamma
            participates in the regulation of caveolin gene expression in human
            carcinoma cells. Caveolin-1 may mediate some of the phenotypic
            changes induced by PPAR-G in cancer cells.
REFERENCE   26 (bases 1 to 2704)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., D, D, Rommens,J.M., Vincent,J.B.,
            Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
  MEDLINE   22616434
   PUBMED   12690205
REFERENCE   27 (bases 1 to 2704)
  AUTHORS   Carrion,R., Morgan,B.E., Tannenbaum,M., Salup,R. and Morgan,M.B.
  TITLE     Caveolin expression in adult renal tumors
  JOURNAL   Urol. Oncol. 21 (3), 191-196 (2003)
  MEDLINE   22695907
   PUBMED   12810205
  REMARK    GeneRIF: A statistically significant difference in the expression
            of caveolin-1 between oncocytoma with a mean labeling index of 91.7
            and other malignant renal tumors with a lower mean labeling index
            possibly implicates this peptide in oncocytoma pathogenesis.
REFERENCE   28 (bases 1 to 2704)
  AUTHORS   Murakami,S., Miyamoto,M., Hida,Y., Cho,Y., Fukunaga,A.,
            Oshikiri,T., Kato,K., Kurokawa,T., Suzuoki,M., Nakakubo,Y.,
            Hiraoka,K., Itoh,T., Shinohara,T., Morikawa,T., Okushiba,O.,
            Kondo,S. and Katoh,H.
  TITLE     Caveolin-I overexpression is a favourable prognostic factor for
            patients with extrahepatic bile duct carcinoma
  JOURNAL   Br. J. Cancer 88 (8), 1234-1238 (2003)
  MEDLINE   22622351
   PUBMED   12737162
  REMARK    GeneRIF: Caveolin-1 expression is an independent positive
            prognostic factor for survival in extrahepatic bile duct carcinoma.
REFERENCE   29 (bases 1 to 2704)
  AUTHORS   Yamaguchi,T., Murata,Y., Fujiyoshi,Y. and Doi,T.
  TITLE     Regulated interaction of endothelin B receptor with caveolin-1
  JOURNAL   Eur. J. Biochem. 270 (8), 1816-1827 (2003)
  MEDLINE   22581140
   PUBMED   12694195
  REMARK    GeneRIF: interacts with endothlin b receptor
REFERENCE   30 (bases 1 to 2704)
  AUTHORS   Sando,G.N., Zhu,H., Weis,J.M., Richman,J.T., Wertz,P.W. and
            Madison,K.C.
  TITLE     Caveolin expression and localization in human keratinocytes suggest
            a role in lamellar granule biogenesis
  JOURNAL   J. Invest. Dermatol. 120 (4), 531-541 (2003)
  MEDLINE   22536009
   PUBMED   12648214
  REMARK    GeneRIF: caveolin-1 may play a role in lamellar granule assembly,
            trafficking, and/or function.
REFERENCE   31 (bases 1 to 2704)
  AUTHORS   Wang,L., Connelly,M.A., Ostermeyer,A.G., Chen,H.H., Williams,D.L.
            and Brown,D.A.
  TITLE     Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or
            selective uptake of cholesteryl ester in two cell lines
  JOURNAL   J. Lipid Res. 44 (4), 807-815 (2003)
  MEDLINE   22555065
   PUBMED   12562842
  REMARK    GeneRIF: basal and SR-BI-stimulated free cholesterol efflux to HDL
            and liposomes and SR-BI-mediated selective uptake of HDL
            cholesteryl ester are not affected by caveolin-1 expression
REFERENCE   32 (bases 1 to 2704)
  AUTHORS   Zschocke,J., Manthey,D., Bayatti,N. and Behl,C.
  TITLE     Functional interaction of estrogen receptor alpha and caveolin
            isoforms in neuronal SK-N-MC cells
  JOURNAL   J. Steroid Biochem. Mol. Biol. 84 (2-3), 167-170 (2003)
  MEDLINE   22597844
   PUBMED   12711000
  REMARK    GeneRIF: ERalpha co-activator caveolin is negatively regulated by
            the steroid receptor itself
REFERENCE   33 (bases 1 to 2704)
  AUTHORS   Wang,X.Q., Sun,P. and Paller,A.S.
  TITLE     Ganglioside induces caveolin-1 redistribution and interaction with
            the epidermal growth factor receptor
  JOURNAL   J. Biol. Chem. 277 (49), 47028-47034 (2002)
  MEDLINE   22344660
   PUBMED   12354760
  REMARK    GeneRIF: both the caveolin-1/EGFR association and EGF-induced
            tyrosine phosphorylation of caveolin-1 are modulated by ganglioside
            GM3
REFERENCE   34 (bases 1 to 2704)
  AUTHORS   Shah,M., Patel,K., Fried,V.A. and Sehgal,P.B.
  TITLE     Interactions of STAT3 with caveolin-1 and heat shock protein 90 in
            plasma membrane raft and cytosolic complexes. Preservation of
            cytokine signaling during fever
  JOURNAL   J. Biol. Chem. 277 (47), 45662-45669 (2002)
  MEDLINE   22323247
   PUBMED   12235142
  REMARK    GeneRIF: Data show that IL-6/raft/STAT3 signaling is a chaperoned
            pathway that involves caveolin-1 and HSP90 as accessory proteins
            and suggest a mechanism for the preservation of this signaling
            during fever.
REFERENCE   35 (bases 1 to 2704)
  AUTHORS   Ho,C.C., Huang,P.H., Huang,H.Y., Chen,Y.H., Yang,P.C. and Hsu,S.M.
  TITLE     Up-regulated caveolin-1 accentuates the metastasis capability of
            lung adenocarcinoma by inducing filopodia formation
  JOURNAL   Am. J. Pathol. 161 (5), 1647-1656 (2002)
  MEDLINE   22300965
   PUBMED   12414512
  REMARK    GeneRIF: Up-regulated caveolin-1 accentuates the metastasis
            capability of lung adenocarcinoma by inducing filopodia formation.
REFERENCE   36 (bases 1 to 2704)
  AUTHORS   Wu,D. and Terrian,D.M.
  TITLE     Regulation of caveolin-1 expression and secretion by a protein
            kinase cepsilon signaling pathway in human prostate cancer cells
  JOURNAL   J. Biol. Chem. 277 (43), 40449-40455 (2002)
  MEDLINE   22287393
   PUBMED   12185081
  REMARK    GeneRIF: regulation of expression and secretion by a protein kinase
            c epsilon signaling pathway in human prostate cancer cells
REFERENCE   37 (bases 1 to 2704)
  AUTHORS   Kim,Y.N., Dam,P. and Bertics,P.J.
  TITLE     Caveolin-1 phosphorylation in human squamous and epidermoid
            carcinoma cells: dependence on ErbB1 expression and Src activation
  JOURNAL   Exp. Cell Res. 280 (1), 134-147 (2002)
  MEDLINE   22259979
   PUBMED   12372346
  REMARK    GeneRIF: Caveolin-1 phosphorylation in human squamous cell
            carcinoma is dependent on ErbB1 expression and Src activation.
REFERENCE   38 (bases 1 to 2704)
  AUTHORS   Zschocke,J., Manthey,D., Bayatti,N., van der Burg,B., Goodenough,S.
            and Behl,C.
  TITLE     Estrogen receptor alpha-mediated silencing of caveolin gene
            expression in neuronal cells
  JOURNAL   J. Biol. Chem. 277 (41), 38772-38780 (2002)
  MEDLINE   22254812
   PUBMED   12138116
  REMARK    GeneRIF: Data show that ER alpha and not ER beta silences
            caveolin-1/-2 expression in an epigenetic fashion in neuronal
            cells.
REFERENCE   39 (bases 1 to 2704)
  AUTHORS   Wickstr, Alitalo,K. and Keski-Oja,J.
  TITLE     Endostatin associates with integrin alpha5beta1 and caveolin-1, and
            activates Src via a tyrosyl phosphatase-dependent pathway in human
            endothelial cells
  JOURNAL   Cancer Res. 62 (19), 5580-5589 (2002)
  MEDLINE   22246286
   PUBMED   12359771
  REMARK    GeneRIF: Endostatin associates with integrin alpha5beta1 and
            caveolin-1, and activates Src via a tyrosyl phosphatase-dependent
            pathway in human endothelial cells.
REFERENCE   40 (bases 1 to 2704)
  AUTHORS   Lee,H., Park,D.S., Razani,B., Russell,R.G., Pestell,R.G. and
            Lisanti,M.P.
  TITLE     Caveolin-1 mutations (P132L and null) and the pathogenesis of
            breast cancer: caveolin-1 (P132L) behaves in a dominant-negative
            manner and caveolin-1 (-/-) null mice show mammary epithelial cell
            hyperplasia
  JOURNAL   Am. J. Pathol. 161 (4), 1357-1369 (2002)
  MEDLINE   22252372
   PUBMED   12368209
  REMARK    GeneRIF: data clearly implicate loss of functional Cav-1 in the
            pathogenesis of mammary epithelial cell hyperplasia
REFERENCE   41 (bases 1 to 2704)
  AUTHORS   Llano,M., Kelly,T., Vanegas,M., Peretz,M., Peterson,T.E.,
            Simari,R.D. and Poeschla,E.M.
  TITLE     Blockade of human immunodeficiency virus type 1 expression by
            caveolin-1
  JOURNAL   J. Virol. 76 (18), 9152-9164 (2002)
  MEDLINE   22174905
   PUBMED   12186899
  REMARK    GeneRIF: data show that coexpression of caveolin can markedly
            inhibit expression of HIV proviral DNA and establish that the
            inhibition is mediated by the hydrophobic, membrane-associated
            domain
REFERENCE   42 (bases 1 to 2704)
  AUTHORS   Caselli,A., Mazzinghi,B., Camici,G., Manao,G. and Ramponi,G.
  TITLE     Some protein tyrosine phosphatases target in part to lipid rafts
            and interact with caveolin-1
  JOURNAL   Biochem. Biophys. Res. Commun. 296 (3), 692-697 (2002)
  MEDLINE   22165497
   PUBMED   12176037
  REMARK    GeneRIF: Some protein tyrosine phosphatases form molecular
            complexes with caveolin-1 in lipid rafts
REFERENCE   43 (bases 1 to 2704)
  AUTHORS   Wang,Y., Yamaguchi,K., Wada,T., Hata,K., Zhao,X., Fujimoto,T. and
            Miyagi,T.
  TITLE     A close association of the ganglioside-specific sialidase Neu3 with
            caveolin in membrane microdomains
  JOURNAL   J. Biol. Chem. 277 (29), 26252-26259 (2002)
  MEDLINE   22113067
   PUBMED   12011038
  REMARK    GeneRIF: Neu3 functions as a caveolin-related signaling molecule
            within caveolin-rich microdomains
REFERENCE   44 (bases 1 to 2704)
  AUTHORS   Liu,J., Wang,X.B., Park,D.S. and Lisanti,M.P.
  TITLE     Caveolin-1 expression enhances endothelial capillary tubule
            formation
  JOURNAL   J. Biol. Chem. 277 (12), 10661-10668 (2002)
  MEDLINE   21895761
   PUBMED   11748236
  REMARK    GeneRIF: Caveolin-1 expression enhances endothelial capillary
            tubule formation
REFERENCE   45 (bases 1 to 2704)
  AUTHORS   Fujimoto,T., Kogo,H., Nakamura,N. and Ozeki,S.
  TITLE     Microdomains and caveolin
  JOURNAL   Tanpakushitsu Kakusan Koso 47 (4 Suppl), 326-332 (2002)
  MEDLINE   21913460
   PUBMED   11915322
  REMARK    GeneRIF: forms a cholesterol complex and transports it from the
            endoplasmic reticulum to the cell membrane; activates signal
            transduction molecules
REFERENCE   46 (bases 1 to 2704)
  AUTHORS   Kato,K., Hida,Y., Miyamoto,M., Hashida,H., Shinohara,T., Itoh,T.,
            Okushiba,S., Kondo,S. and Katoh,H.
  TITLE     Overexpression of caveolin-1 in esophageal squamous cell carcinoma
            correlates with lymph node metastasis and pathologic stage
  JOURNAL   Cancer 94 (4), 929-933 (2002)
  MEDLINE   21916551
   PUBMED   11920460
  REMARK    GeneRIF: over-expression is associated with lymph node metastasis
            and worse prognosis after surgery in esophageal squamous cell
            carcinoma
REFERENCE   47 (bases 1 to 2704)
  AUTHORS   Eberle,H.B., Serrano,R.L., F, Schlosser,A., Lehmann,W.D.,
            Lottspeich,F., Kaloyanova,D., Wieland,F.T. and Helms,J.B.
  TITLE     Identification and characterization of a novel human plant
            pathogenesis-related protein that localizes to lipid-enriched
            microdomains in the Golgi complex
  JOURNAL   J. Cell. Sci. 115 (Pt 4), 827-838 (2002)
  MEDLINE   21853395
   PUBMED   11865038
REFERENCE   48 (bases 1 to 2704)
  AUTHORS   Maler, Juvet,K., Gj and Berg,T.
  TITLE     The expression of scavenger receptor class B, type I (SR-BI) and
            caveolin-1 in parenchymal and nonparenchymal liver cells
  JOURNAL   Cell Tissue Res. 307 (2), 173-180 (2002)
  MEDLINE   21833019
   PUBMED   11845324
  REMARK    GeneRIF: CAV1 was found in liver endothelial cells and in Kupffer
            cells (liver non-parenchymal cells).
REFERENCE   49 (bases 1 to 2704)
  AUTHORS   Virgintino,D., Robertson,D., Errede,M., Benagiano,V., Tauer,U.,
            Roncali,L. and Bertossi,M.
  TITLE     Expression of caveolin-1 in human brain microvessels
  JOURNAL   Neuroscience 115 (1), 145-152 (2002)
  MEDLINE   22289770
   PUBMED   12401329
  REMARK    GeneRIF: In the cerebral cortex caveolin-1 is expressed by all the
            cell types that form the vascular wall, endothelial cells,
            pericytes, and vascular astrocytes in vivo.
REFERENCE   50 (bases 1 to 2704)
  AUTHORS   Engelman,J.A., Zhang,X.L. and Lisanti,M.P.
  TITLE     Sequence and detailed organization of the human caveolin-1 and -2
            genes located near the D7S522 locus (7q31.1). Methylation of a CpG
            island in the 5' promoter region of the caveolin-1 gene in human
            breast cancer cell lines
  JOURNAL   FEBS Lett. 448 (2-3), 221-230 (1999)
  MEDLINE   99232848
   PUBMED   10218480
REFERENCE   51 (bases 1 to 2704)
  AUTHORS   Fra,A.M., Mastroianni,N., Mancini,M., Pasqualetto,E. and Sitia,R.
  TITLE     Human caveolin-1 and caveolin-2 are closely linked genes
            colocalized with WI-5336 in a region of 7q31 frequently deleted in
            tumors
  JOURNAL   Genomics 56 (3), 355-356 (1999)
  MEDLINE   99189247
   PUBMED   10087206
REFERENCE   52 (bases 1 to 2704)
  AUTHORS   Hurlstone,A.F., Reid,G., Reeves,J.R., Fraser,J., Strathdee,G.,
            Rahilly,M., Parkinson,E.K. and Black,D.M.
  TITLE     Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in
            primary tumours and tumour-derived cell lines
  JOURNAL   Oncogene 18 (10), 1881-1890 (1999)
  MEDLINE   99184146
   PUBMED   10086342
REFERENCE   53 (bases 1 to 2704)
  AUTHORS   Engelman,J.A., Zhang,X., Galbiati,F., Volonte,D., Sotgia,F.,
            Pestell,R.G., Minetti,C., Scherer,P.E., Okamoto,T. and Lisanti,M.P.
  TITLE     Molecular genetics of the caveolin gene family: implications for
            human cancers, diabetes, Alzheimer disease, and muscular dystrophy
  JOURNAL   Am. J. Hum. Genet. 63 (6), 1578-1587 (1998)
  MEDLINE   99057494
   PUBMED   9837809
REFERENCE   54 (bases 1 to 2704)
  AUTHORS   Engelman,J.A., Zhang,X.L. and Lisanti,M.P.
  TITLE     Genes encoding human caveolin-1 and -2 are co-localized to the
            D7S522 locus (7q31.1), a known fragile site (FRA7G) that is
            frequently deleted in human cancers
  JOURNAL   FEBS Lett. 436 (3), 403-410 (1998)
  MEDLINE   99015777
   PUBMED   9801158
REFERENCE   55 (bases 1 to 2704)
  AUTHORS   Wary,K.K., Mariotti,A., Zurzolo,C. and Giancotti,F.G.
  TITLE     A requirement for caveolin-1 and associated kinase Fyn in integrin
            signaling and anchorage-dependent cell growth
  JOURNAL   Cell 94 (5), 625-634 (1998)
  MEDLINE   98412658
   PUBMED   9741627
REFERENCE   56 (bases 1 to 2704)
  AUTHORS   Bist,A., Fielding,P.E. and Fielding,C.J.
  TITLE     Two sterol regulatory element-like sequences mediate up-regulation
            of caveolin gene transcription in response to low density
            lipoprotein free cholesterol
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (20), 10693-10698 (1997)
  MEDLINE   98021431
   PUBMED   9380697
REFERENCE   57 (bases 1 to 2704)
  AUTHORS   Glenney,J.R. Jr.
  TITLE     The sequence of human caveolin reveals identity with VIP21, a
            component of transport vesicles
  JOURNAL   FEBS Lett. 314 (1), 45-48 (1992)
  MEDLINE   93083646
   PUBMED   1360410
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z18951.1, AF125348.1 and
            AI878826.1.
            On Sep 6, 2001 this sequence version replaced gi:4580417.
            
            Summary: The scaffolding protein encoded by this gene is the main
            component of the caveolae plasma membranes found in most cell
            types. The protein links integrin subunits to the tyrosine kinase
            FYN, an initiating step in coupling integrins to the Ras-ERK
            pathway and promoting cell cycle progression. The gene is a tumor
            suppressor gene candidate and a negative regulator of the
            Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to
            each other on chromosome 7 and express colocalizing proteins that
            form a stable hetero-oligomeric complex. By using alternative
            initiation codons in the same reading frame, two isoforms (alpha
            and beta) are encoded by a single transcript from this gene.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..2704
                     /gene="CAV1"
                     /note="synonyms: CAV, VIP21, MSTP085"
                     /db_xref="GeneID:857"
                     /db_xref="MIM:601047"
     CDS             279..815
                     /gene="CAV1"
                     /note="caveolae protein, 22-kD; caveolin 1 caveolae
                     protein, 22kD; caveolin 1, alpha isoform; caveolin 1, beta
                     isoform;
                     go_component: caveolar membrane [goid 0016599] [evidence
                     IDA] [pmid 15219854];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 1360410];
                     go_function: structural molecule activity [goid 0005198]
                     [evidence IDA] [pmid 11865038];
                     go_process: biological_process unknown [goid 0000004]
                     [evidence ND]"
                     /codon_start=1
                     /product="caveolin 1"
                     /protein_id="NP_001744.2"
                     /db_xref="GI:15451856"
                     /db_xref="GeneID:857"
                     /db_xref="MIM:601047"
                     /translation="MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDA
                     HTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRL
                     LSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLF
                     EAVGKIFSNVRINLQKEI"
     misc_feature    372..374
                     /gene="CAV1"
                     /note="caveolin 1, beta isoform; Region: alternative
                     translation initiation site"
     polyA_signal    2685..2690
                     /gene="CAV1"
     polyA_site      2704
                     /gene="CAV1"
                     /evidence=experimental
ORIGIN      
        1 gggagaaacg ttctcactcg ctctctgctc gctgcgggcg ctccccgccc tctgctgcca
       61 gaaccttggg gatgtgccta gacccggcgc agcacacgtc cgggccaacc gcgagcagaa
      121 caaacctttg gcgggcggcc aggaggctcc ctcccagcca ccgcccccct ccagcgcctt
      181 tttttccccc catacaatac aagatcttcc ttcctcagtt cccttaaagc acagcccagg
      241 gaaacctcct cacagttttc atccagccac gggccagcat gtctgggggc aaatacgtag
      301 actcggaggg acatctctac accgttccca tccgggaaca gggcaacatc tacaagccca
      361 acaacaaggc catggcagac gagctgagcg agaagcaagt gtacgacgcg cacaccaagg
      421 agatcgacct ggtcaaccgc gaccctaaac acctcaacga tgacgtggtc aagattgact
      481 ttgaagatgt gattgcagaa ccagaaggga cacacagttt tgacggcatt tggaaggcca
      541 gcttcaccac cttcactgtg acgaaatact ggttttaccg cttgctgtct gccctctttg
      601 gcatcccgat ggcactcatc tggggcattt acttcgccat tctctctttc ctgcacatct
      661 gggcagttgt accatgcatt aagagcttcc tgattgagat tcagtgcatc agccgtgtct
      721 attccatcta cgtccacacc gtctgtgacc cactctttga agctgttggg aaaatattca
      781 gcaatgtccg catcaacttg cagaaagaaa tataaatgac atttcaagga tagaagtata
      841 cctgattttt tttcctttta attttcctgg tgccaatttc aagttccaag ttgctaatac
      901 agcaacaatt tatgaattga attatcttgg ttgaaaataa aaagatcact ttctcagttt
      961 tcataagtat tatgtctctt ctgagctatt tcatctattt ttggcagtct gaatttttaa
     1021 aacccattta aatttttttc cttacctttt tatttgcatg tggatcaacc atcgctttat
     1081 tggctgagat atgaacatat tgttgaaagg taatttgaga gaaatatgaa gaactgagga
     1141 ggaaaaaaaa aaaaaagaaa agaaccaaca acctcaactg cctactccaa aatgttggtc
     1201 attttatgtt aagggaagaa ttccagggta tggccatgga gtgtacaagt atgtgggcag
     1261 attttcagca aactcttttc ccactgttta aggagttagt ggattactgc cattcacttc
     1321 ataatccagt aggatccagt gatccttaca agttagaaaa cataatcttc tgccttctca
     1381 tgatccaact aatgccttac tcttcttgaa attttaacct atgatatttt ctgtgcctga
     1441 atatttgtta tgtagataac aagacctcag tgccttcctg tttttcacat tttccttttc
     1501 aaatagggtc taactcagca actcgcttta ggtcagcagc ctccctgaag accaaaatta
     1561 gaatatccat gacctagttt tccatgcgtg tttctgactc tgagctacag agtctggtga
     1621 agctcacttc tgggcttcat ctggcaacat ctttatccgt agtgggtatg gttgacacta
     1681 gcccaatgaa atgaattaaa gtggaccaat agggctgagc tctctgtggg ctggcagtcc
     1741 tggaagccag ctttccctgc ctctcatcaa ctgaatgagg tcagcatgtc tattcagctt
     1801 cgtttatttt caagaataat cacgctttcc tgaatccaaa ctaatccatc accggggtgg
     1861 tttagtggct caacattgtg ttcccatttc agctgatcag tgggcctcca aggaggggct
     1921 gtaaaatgga ggccattgtg tgagcctatc agagttgctg caaacctgac ccctgctcag
     1981 taaagcactt gcaaccgtct gttatgctgt gacacatggc ccctccccct gccaggagct
     2041 ttggacctaa tccaagcatc cctttgccca gaaagaagat gggggaggag gcagtaataa
     2101 aaagattgaa gtattttgct ggaataagtt caaattcttc tgaactcaaa ctgaggaatt
     2161 tcacctgtaa acctgagtcg tacagaaagc tgcctggtat atccaaaagc tttttattcc
     2221 tcctgctcat attgtgattc tgcctttggg gacttttctt aaaccttcag ttatgatttt
     2281 tttttcatac acttattgga actctgcttg atttttgcct cttccagtct tcctgacact
     2341 ttaattacca acctgttacc tactttgact ttttgcattt aaaacagaca ctggcatgga
     2401 tatagtttta cttttaaact gtgtacataa ctgaaaatgt gctatactgc atacttttta
     2461 aatgtaaaga tatttttatc tttatatgaa gaaaatcact taggaaatgg ctttgtgatt
     2521 caatctgtaa actgtgtatt ccaagacatg tctgttctac atagatgctt agtccctcat
     2581 gcaaatcaat tactggtcca aaagattgct gaaattttat atgcttactg atatatttta
     2641 caatttttta tcatgcatgt cctgtaaagg ttacaagcct gcacaataaa aatgtttaac
     2701 ggtt
//

LOCUS       NM_001901               2312 bp    mRNA    linear   PRI 14-DEC-2004
DEFINITION  Homo sapiens connective tissue growth factor (CTGF), mRNA.
ACCESSION   NM_001901
VERSION     NM_001901.1  GI:4503122
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Zhang,C., Meng,X., Zhu,Z., Yang,X. and Deng,A.
  TITLE     Role of connective tissue growth factor in renal tubular
            epithelial-myofibroblast transdifferentiation and extracellular
            matrix accumulation in vitro
  JOURNAL   Life Sci. 75 (3), 367-379 (2004)
   PUBMED   15135656
  REMARK    GeneRIF: CTGF may play a crucial role in the renal tubular
            epithelial-transdifferentiation and the following
            deposition/degradation process of extracellular matrix during
            tubulointerstitial fibrosis
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Leask,A.
  TITLE     Transcriptional profiling of the scleroderma fibroblast reveals a
            potential role for connective tissue growth factor (CTGF) in
            pathological fibrosis
  JOURNAL   Diabetes Care 53 (2), 74-77 (2004)
   PUBMED   15247510
  REMARK    GeneRIF: CTGF has a role in scleroderma and in pathological
            fibrosis [review]
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Roestenberg,P., van Nieuwenhoven,F.A., Wieten,L., Boer,P.,
            Diekman,T., Tiller,A.M., Wiersinga,W.M., Oliver,N., Usinger,W.,
            Weitz,S., Schlingemann,R.O. and Goldschmeding,R.
  TITLE     Connective tissue growth factor is increased in plasma of type 1
            diabetic patients with nephropathy
  JOURNAL   Diabetes Care 27 (5), 1164-1170 (2004)
   PUBMED   15111539
  REMARK    GeneRIF: Levels are elevated in type 1 diabetic patients with
            nephropathy and appear to be correlated with proteinuria and
            creatinine clearance.
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Schild,C. and Trueb,B.
  TITLE     Three members of the connective tissue growth factor family CCN are
            differentially regulated by mechanical stress
  JOURNAL   Biochim. Biophys. Acta 1691 (1), 33-40 (2004)
   PUBMED   15053922
  REMARK    GeneRIF: evidence that adenylate cyclase as well as one or several
            protein kinases might be involved in the mechanoregulation of
            Cyr61, CTGF and Nov genes
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   Cicha,I., Garlichs,C.D., Daniel,W.G. and Goppelt-Struebe,M.
  TITLE     Activated human platelets release connective tissue growth factor
  JOURNAL   Thromb. Haemost. 91 (4), 755-760 (2004)
   PUBMED   15045137
  REMARK    GeneRIF: unstimulated platelets contain considerable amounts of
            CTGF; CTGF presence in platelets is a result of endocytosis from
            extracellular environment in bone marrow; agonist-stimulation of
            platelets resulted in release of CTGF from the storage granules
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   Gao,R. and Brigstock,D.R.
  TITLE     Connective tissue growth factor (CCN2) induces adhesion of rat
            activated hepatic stellate cells by binding of its C-terminal
            domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan
  JOURNAL   J. Biol. Chem. 279 (10), 8848-8855 (2004)
   PUBMED   14684735
  REMARK    GeneRIF: the sequence IRTPKISKPIKFELSG within CCN2is a unique
            binding domain for integrin alpha(v)beta(3) that is sufficient to
            mediate hepatic stellate cell adhesion
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Chang,C.C., Shih,J.Y., Jeng,Y.M., Su,J.L., Lin,B.Z., Chen,S.T.,
            Chau,Y.P., Yang,P.C. and Kuo,M.L.
  TITLE     Connective tissue growth factor and its role in lung adenocarcinoma
            invasion and metastasis
  JOURNAL   J. Natl. Cancer Inst. 96 (5), 364-375 (2004)
   PUBMED   14996858
  REMARK    GeneRIF: CTGF inhibits metastasis and invasion of human lung
            adenocarcinoma by a CRMP-1-dependent mechanism.
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Grotendorst,G.R., Rahmanie,H. and Duncan,M.R.
  TITLE     Combinatorial signaling pathways determine fibroblast proliferation
            and myofibroblast differentiation
  JOURNAL   FASEB J. 18 (3), 469-479 (2004)
   PUBMED   15003992
  REMARK    GeneRIF: Fibroblast proliferation, differentiation into
            myofibroblasts, & increased collagen synthesis are regulated via a
            CTGF-dependent pathway. CTGF serves to control a pivotal switch
            point in the cascade for connective tissue formation.
REFERENCE   9  (bases 1 to 2312)
  AUTHORS   Hinton,D.R., Spee,C., He,S., Weitz,S., Usinger,W., LaBree,L.,
            Oliver,N. and Lim,J.I.
  TITLE     Accumulation of NH2-terminal fragment of connective tissue growth
            factor in the vitreous of patients with proliferative diabetic
            retinopathy
  JOURNAL   Diabetes Care 27 (3), 758-764 (2004)
   PUBMED   14988298
  REMARK    GeneRIF: The NH2-terminal CTGF fragment content is increased in the
            vitreous of patients with proliferative diabetic retinopathy.
REFERENCE   10 (bases 1 to 2312)
  AUTHORS   Kanemoto,K., Usui,J., Nitta,K., Horita,S., Harada,A., Koyama,A.,
            Aten,J. and Nagata,M.
  TITLE     In situ expression of connective tissue growth factor in human
            crescentic glomerulonephritis
  JOURNAL   Virchows Arch. 444 (3), 257-263 (2004)
   PUBMED   14758550
  REMARK    GeneRIF: results suggest that connective tissue growth factor(CTGF)
            is involved in extracellular matrix production in parietal
            epithelial cells and that it is one of the mediators promoting the
            scarring process in glomerular crescents
REFERENCE   11 (bases 1 to 2312)
  AUTHORS   Abdel Wahab,N. and Mason,R.M.
  TITLE     Connective tissue growth factor and renal diseases: some answers,
            more questions
  JOURNAL   Diabetes Care 13 (1), 53-58 (2004)
  MEDLINE   23281041
   PUBMED   15090860
  REMARK    GeneRIF: connective tissue growth factor seems to be an attractive
            alternative therapeutic target for combating renal fibrosis--REVIEW
REFERENCE   12 (bases 1 to 2312)
  AUTHORS   Lam,S., van der Geest,R.N., Verhagen,N.A., van Nieuwenhoven,F.A.,
            Blom,I.E., Aten,J., Goldschmeding,R., Daha,M.R. and van Kooten,C.
  TITLE     Connective tissue growth factor and igf-I are produced by human
            renal fibroblasts and cooperate in the induction of collagen
            production by high glucose
  JOURNAL   Diabetes 52 (12), 2975-2983 (2003)
  MEDLINE   22995172
   PUBMED   14633859
  REMARK    GeneRIF: Cooperation between CTGF and IGF-I might be involved in
            glucose-induced matrix accumulation in tubulointerstitial fibrosis
            and might contribute to pathogenesis of diabetic nephropathy.
REFERENCE   13 (bases 1 to 2312)
  AUTHORS   Ott,C., Iwanciw,D., Graness,A., Giehl,K. and Goppelt-Struebe,M.
  TITLE     Modulation of the expression of connective tissue growth factor by
            alterations of the cytoskeleton
  JOURNAL   J. Biol. Chem. 278 (45), 44305-44311 (2003)
  MEDLINE   22957335
   PUBMED   12951326
  REMARK    GeneRIF: data link alterations in the microtubule and actin
            cytoskeleton to the expression of connective tissue growth factor
REFERENCE   14 (bases 1 to 2312)
  AUTHORS   Holmes,A., Abraham,D.J., Chen,Y., Denton,C., Shi-wen,X., Black,C.M.
            and Leask,A.
  TITLE     Constitutive connective tissue growth factor expression in
            scleroderma fibroblasts is dependent on Sp1
  JOURNAL   J. Biol. Chem. 278 (43), 41728-41733 (2003)
  MEDLINE   22928083
   PUBMED   12888575
  REMARK    GeneRIF: the constitutive overexpression of CTGF in SSc fibroblasts
            seems to be independent of TGFbeta signaling but dependent at least
            in part on Sp1
REFERENCE   15 (bases 1 to 2312)
  AUTHORS   Deininger,M.H., Winkler,S., Kremsner,P.G., Meyermann,R. and
            Schluesener,H.J.
  TITLE     Angiogenic proteins in brains of patients who died with cerebral
            malaria
  JOURNAL   J. Neuroimmunol. 142 (1-2), 101-111 (2003)
  MEDLINE   22874781
   PUBMED   14512169
  REMARK    GeneRIF: Postmortem brain tissue analysis demonstrates CTGF
            localized occasionally in astrocytes but not in
            macrophages/microglial cells of patients with cerebral malaria.
REFERENCE   16 (bases 1 to 2312)
  AUTHORS   Gilbert,R.E., Akdeniz,A., Weitz,S., Usinger,W.R., Molineaux,C.,
            Jones,S.E., Langham,R.G. and Jerums,G.
  TITLE     Urinary connective tissue growth factor excretion in patients with
            type 1 diabetes and nephropathy
  JOURNAL   Diabetes Care 26 (9), 2632-2636 (2003)
  MEDLINE   22822361
   PUBMED   12941731
  REMARK    GeneRIF: Magnitude of Urinary CTGF NH(2)-terminal fragment
            excretion is related to the severity of diabetic nephropathy
REFERENCE   17 (bases 1 to 2312)
  AUTHORS   Nishida,T., Kubota,S., Fukunaga,T., Kondo,S., Yosimichi,G.,
            Nakanishi,T., Takano-Yamamoto,T. and Takigawa,M.
  TITLE     CTGF/Hcs24, hypertrophic chondrocyte-specific gene product,
            interacts with perlecan in regulating the proliferation and
            differentiation of chondrocytes
  JOURNAL   J. Cell. Physiol. 196 (2), 265-275 (2003)
  MEDLINE   22695170
   PUBMED   12811819
  REMARK    GeneRIF: CTGF/Hcs24 produced in the hypertrophic region may act on
            chondrocytes in the proliferative and maturative zone via some
            heparan sulfate proteoglycan, such as perlecan.
REFERENCE   18 (bases 1 to 2312)
  AUTHORS   Zarrinkalam,K.H., Stanley,J.M., Gray,J., Oliver,N. and Faull,R.J.
  TITLE     Connective tissue growth factor and its regulation in the
            peritoneal cavity of peritoneal dialysis patients
  JOURNAL   Kidney Int. 64 (1), 331-338 (2003)
  MEDLINE   22672640
   PUBMED   12787426
  REMARK    GeneRIF: Production of CTGF by peritoneal mesothelial cells and its
            presence in peritoneal cavity in peritoneal dialysis. Increase in
            CTGF in peritoneal membrane fibrosis suggests involvement in
            underlying pathophysiologic mechanism(s).
REFERENCE   19 (bases 1 to 2312)
  AUTHORS   Utsugi,M., Dobashi,K., Ishizuka,T., Masubuchi,K., Shimizu,Y.,
            Nakazawa,T. and Mori,M.
  TITLE     C-Jun-NH2-terminal kinase mediates expression of connective tissue
            growth factor induced by transforming growth factor-beta1 in human
            lung fibroblasts
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 28 (6), 754-761 (2003)
  MEDLINE   22645707
   PUBMED   12760970
  REMARK    GeneRIF: These results suggest that TGF-beta1-induced CTGF mRNA
            expression is mediated through the JNK-dependent pathway, whereas
            p38 MAP kinase and ERK pathways minimally contribute
REFERENCE   20 (bases 1 to 2312)
  AUTHORS   Leask,A., Holmes,A., Black,C.M. and Abraham,D.J.
  TITLE     Connective tissue growth factor gene regulation. Requirements for
            its induction by transforming growth factor-beta 2 in fibroblasts
  JOURNAL   J. Biol. Chem. 278 (15), 13008-13015 (2003)
  MEDLINE   22566080
   PUBMED   12571253
  REMARK    GeneRIF: Gene expression regulation requires tgf-beta2 in
            fibroblasts.
REFERENCE   21 (bases 1 to 2312)
  AUTHORS   Moritani,N.H., Kubota,S., Nishida,T., Kawaki,H., Kondo,S.,
            Sugahara,T. and Takigawa,M.
  TITLE     Suppressive effect of overexpressed connective tissue growth factor
            on tumor cell growth in a human oral squamous cell
            carcinoma-derived cell line
  JOURNAL   Cancer Lett. 192 (2), 205-214 (2003)
  MEDLINE   22554283
   PUBMED   12668285
  REMARK    GeneRIF: CTGF acts as a negative regulator of the cell growth in
            oral squamous cell carcinoma possibly through its interaction with
            growth modifiers inside the cell
REFERENCE   22 (bases 1 to 2312)
  AUTHORS   Weston,B.S., Wahab,N.A. and Mason,R.M.
  TITLE     CTGF mediates TGF-beta-induced fibronectin matrix deposition by
            upregulating active alpha5beta1 integrin in human mesangial cells
  JOURNAL   J. Am. Soc. Nephrol. 14 (3), 601-610 (2003)
  MEDLINE   22483796
   PUBMED   12595495
  REMARK    GeneRIF: Alterations in alpha5beta1 levels induced by TGF-beta are
            mediated at least in part through the induction of CTGF in
            glomerular mesangium
REFERENCE   23 (bases 1 to 2312)
  AUTHORS   Workalemahu,G., Foerster,M., Kroegel,C. and Braun,R.K.
  TITLE     Human gamma delta-T lymphocytes express and synthesize connective
            tissue growth factor: effect of IL-15 and TGF-beta 1 and comparison
            with alpha beta-T lymphocytes
  JOURNAL   J. Immunol. 170 (1), 153-157 (2003)
  MEDLINE   22384468
   PUBMED   12496395
  REMARK    GeneRIF: In contrast to CD4+ alpha beta-T cells, gamma delta-T
            cells are capable of expressing CTGF mRNA and synthesizing its
            corresponding protein, which supports the concept that gamma
            delta-T cells contribute to wound healing or tissue fibrotic
            processes.
REFERENCE   24 (bases 1 to 2312)
  AUTHORS   Ueberham,U., Ueberham,E., Gruschka,H. and Arendt,T.
  TITLE     Connective tissue growth factor in Alzheimer's disease
  JOURNAL   Neuroscience 116 (1), 1-6 (2003)
  MEDLINE   22423883
   PUBMED   12535930
  REMARK    GeneRIF: In brains from Alzheimer's patients, a strong
            tangle-associated CTGF immunoreactivity was observed in entorhinal
            cortex, hippocampus and temporal cortex.
REFERENCE   25 (bases 1 to 2312)
  AUTHORS   Yosimichi,G., Kubota,S., Hattori,T., Nishida,T., Nawachi,K.,
            Nakanishi,T., Kamada,M., Takano-Yamamoto,T. and Takigawa,M.
  TITLE     CTGF/Hcs24 interacts with the cytoskeletal protein actin in
            chondrocytes
  JOURNAL   Biochem. Biophys. Res. Commun. 299 (5), 755-761 (2002)
  MEDLINE   22358404
   PUBMED   12470643
  REMARK    GeneRIF: CTGF interacts with the cytoskeletal protein actin in
            chondrocytes.
REFERENCE   26 (bases 1 to 2312)
  AUTHORS   Crean,J.K., Finlay,D., Murphy,M., Moss,C., Godson,C., Martin,F. and
            Brady,H.R.
  TITLE     The role of p42/44 MAPK and protein kinase B in connective tissue
            growth factor induced extracellular matrix protein production, cell
            migration, and actin cytoskeletal rearrangement in human mesangial
            cells
  JOURNAL   J. Biol. Chem. 277 (46), 44187-44194 (2002)
  MEDLINE   22313537
   PUBMED   12218048
  REMARK    GeneRIF: CTGF mediates a number of its biological effects by the
            induction of signaling processes via beta(3) integrin
REFERENCE   27 (bases 1 to 2312)
  AUTHORS   Nakata,E., Nakanishi,T., Kawai,A., Asaumi,K., Yamaai,T., Asano,M.,
            Nishida,T., Mitani,S., Inoue,H. and Takigawa,M.
  TITLE     Expression of connective tissue growth factor/hypertrophic
            chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture
            healing
  JOURNAL   Bone 31 (4), 441-447 (2002)
  MEDLINE   22286046
   PUBMED   12398938
  REMARK    GeneRIF: localization and expression during fracture healing
REFERENCE   28 (bases 1 to 2312)
  AUTHORS   Abdel-Wahab,N., Weston,B.S., Roberts,T. and Mason,R.M.
  TITLE     Connective tissue growth factor and regulation of the mesangial
            cell cycle: role in cellular hypertrophy
  JOURNAL   J. Am. Soc. Nephrol. 13 (10), 2437-2445 (2002)
  MEDLINE   22224588
   PUBMED   12239232
  REMARK    GeneRIF: CTGF is a hypertrophic factor for human mesangial cells.
            molecular mechanisms underlying this G(1) phase arrest appear to be
            due to the induction of the cyclin-dependent kinase inhibitors
            (CDKI) p15(INK4), p21(Cip1), and p27(Kip1).
REFERENCE   29 (bases 1 to 2312)
  AUTHORS   Gore-Hyer,E., Shegogue,D., Markiewicz,M., Lo,S., Hazen-Martin,D.,
            Greene,E.L., Grotendorst,G. and Trojanowska,M.
  TITLE     TGF-beta and CTGF have overlapping and distinct fibrogenic effects
            on human renal cells
  JOURNAL   Am. J. Physiol. Renal Physiol. 283 (4), F707-F716 (2002)
  MEDLINE   22205710
   PUBMED   12217862
  REMARK    GeneRIF: role in epithelial-mesenchymal transdifferentiation
REFERENCE   30 (bases 1 to 2312)
  AUTHORS   Hashimoto,G., Inoki,I., Fujii,Y., Aoki,T., Ikeda,E. and Okada,Y.
  TITLE     Matrix metalloproteinases cleave connective tissue growth factor
            and reactivate angiogenic activity of vascular endothelial growth
            factor 165
  JOURNAL   J. Biol. Chem. 277 (39), 36288-36295 (2002)
  MEDLINE   22229325
   PUBMED   12114504
  REMARK    GeneRIF: CTGF has a role in binding to MMPs and VEGF-induced
            physiological or pathologic angiogenesis
REFERENCE   31 (bases 1 to 2312)
  AUTHORS   Eguchi,T., Kubota,S., Kondo,S., Kuboki,T., Yatani,H. and
            Takigawa,M.
  TITLE     A novel cis-element that enhances connective tissue growth factor
            gene expression in chondrocytic cells
  JOURNAL   Biochem. Biophys. Res. Commun. 295 (2), 445-451 (2002)
  MEDLINE   22145750
   PUBMED   12150969
  REMARK    GeneRIF: enhancement of expression on chondrocytes by a novel
            cis-element
REFERENCE   32 (bases 1 to 2312)
  AUTHORS   Schober,J.M., Chen,N., Grzeszkiewicz,T.M., Jovanovic,I.,
            Emeson,E.E., Ugarova,T.P., Ye,R.D., Lau,L.F. and Lam,S.C.
  TITLE     Identification of integrin alpha(M)beta(2) as an adhesion receptor
            on peripheral blood monocytes for Cyr61 (CCN1) and connective
            tissue growth factor (CCN2): immediate-early gene products
            expressed in atherosclerotic lesions
  JOURNAL   Blood 99 (12), 4457-4465 (2002)
  MEDLINE   22032680
   PUBMED   12036876
  REMARK    GeneRIF: Identification of integrin alpha(M)beta(2) as an adhesion
            receptor on human peripheral blood monocytes for Cyr61 and
            connective tissue growth factor: immediate-early gene products
            expressed in atherosclerotic lesions.
REFERENCE   33 (bases 1 to 2312)
  AUTHORS   Kondo,S., Kubota,S., Shimo,T., Nishida,T., Yosimichi,G., Eguchi,T.,
            Sugahara,T. and Takigawa,M.
  TITLE     Connective tissue growth factor increased by hypoxia may initiate
            angiogenesis in collaboration with matrix metalloproteinases
  JOURNAL   Carcinogenesis 23 (5), 769-776 (2002)
  MEDLINE   22011758
   PUBMED   12016149
  REMARK    GeneRIF: role in initiating angiogenesis in collaboration with
            matrix metalloproteinases
REFERENCE   34 (bases 1 to 2312)
  AUTHORS   Twigg,S.M., Joly,A.H., Chen,M.M., Tsubaki,J., Kim,H.S., Hwa,V.,
            Oh,Y. and Rosenfeld,R.G.
  TITLE     Connective tissue growth factor/IGF-binding protein-related
            protein-2 is a mediator in the induction of fibronectin by advanced
            glycosylation end-products in human dermal fibroblasts
  JOURNAL   Endocrinology 143 (4), 1260-1269 (2002)
  MEDLINE   21895431
   PUBMED   11897682
  REMARK    GeneRIF: the induction of FN by AGE is partly mediated by the
            AGE-induced up-regulation of cell-derived CTGF and is dependent on
            PKC activity
REFERENCE   35 (bases 1 to 2312)
  AUTHORS   Schild,C. and Trueb,B.
  TITLE     Mechanical stress is required for high-level expression of
            connective tissue growth factor
  JOURNAL   Exp. Cell Res. 274 (1), 83-91 (2002)
  MEDLINE   21846027
   PUBMED   11855859
  REMARK    GeneRIF: Mechanical stress is required for high-level expression of
            connective tissue growth factor in fibroblasts.
REFERENCE   36 (bases 1 to 2312)
  AUTHORS   Brigstock,D.R.
  TITLE     Regulation of angiogenesis and endothelial cell function by
            connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61)
  JOURNAL   J. Cell. Physiol. 5 (3), 153-165 (2002)
  MEDLINE   22714549
   PUBMED   12831056
  REMARK    GeneRIF: Regulates angiogenesis and endothelial cell function.
            (review)
REFERENCE   37 (bases 1 to 2312)
  AUTHORS   Rishikof,D.C., Ricupero,D.A., Kuang,P.P., Liu,H. and Goldstein,R.H.
  TITLE     Interleukin-4 regulates connective tissue growth factor expression
            in human lung fibroblasts
  JOURNAL   J. Cell. Biochem. 85 (3), 496-504 (2002)
  MEDLINE   22021592
   PUBMED   11967989
  REMARK    GeneRIF: IL-4 interfered with the TGF-beta-induced transcriptional
            activation of the CTGF gene.
REFERENCE   38 (bases 1 to 2312)
  AUTHORS   Xie,D., Nakachi,K., Wang,H., Elashoff,R. and Koeffler,H.P.
  TITLE     Elevated levels of connective tissue growth factor, WISP-1, and
            CYR61 in primary breast cancers associated with more advanced
            features
  JOURNAL   Cancer Res. 61 (24), 8917-8923 (2001)
  MEDLINE   21621928
   PUBMED   11751417
  REMARK    GeneRIF: Elevated levels of connective tissue growth factor,
            WISP-1, and CYR61 in primary breast cancers associated with more
            advanced features.
REFERENCE   39 (bases 1 to 2312)
  AUTHORS   Abraham,D.J., Shiwen,X., Black,C.M., Sa,S., Xu,Y. and Leask,A.
  TITLE     Tumor necrosis factor alpha suppresses the induction of connective
            tissue growth factor by transforming growth factor-beta in normal
            and scleroderma fibroblasts
  JOURNAL   J. Biol. Chem. 275 (20), 15220-15225 (2000)
  MEDLINE   20270231
   PUBMED   10809757
REFERENCE   40 (bases 1 to 2312)
  AUTHORS   Kim,H.S., Nagalla,S.R., Oh,Y., Wilson,E., Roberts,C.T. Jr. and
            Rosenfeld,R.G.
  TITLE     Identification of a family of low-affinity insulin-like growth
            factor binding proteins (IGFBPs): characterization of connective
            tissue growth factor as a member of the IGFBP superfamily
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (24), 12981-12986 (1997)
  MEDLINE   98058755
   PUBMED   9371786
REFERENCE   41
  AUTHORS   Oemar,B.S., Werner,A., Garnier,J.M., Do,D.D., Godoy,N., Nauck,M.,
            Marz,W., Rupp,J., Pech,M. and Luscher,T.F.
  TITLE     Human connective tissue growth factor is expressed in advanced
            atherosclerotic lesions
  JOURNAL   Circulation 95 (4), 831-839 (1997)
  MEDLINE   97207446
   PUBMED   9054739
REFERENCE   42 (bases 1 to 2312)
  AUTHORS   Martinerie,C., Viegas-Pequignot,E., Guenard,I., Dutrillaux,B.,
            Nguyen,V.C., Bernheim,A. and Perbal,B.
  TITLE     Physical mapping of human loci homologous to the chicken nov
            proto-oncogene
  JOURNAL   Oncogene 7 (12), 2529-2534 (1992)
  MEDLINE   93096489
   PUBMED   1334251
REFERENCE   43 (bases 1 to 2312)
  AUTHORS   Sutter,T.R., Guzman,K., Dold,K.M. and Greenlee,W.F.
  TITLE     Targets for dioxin: genes for plasminogen activator inhibitor-2 and
            interleukin-1 beta
  JOURNAL   Science 254 (5030), 415-418 (1991)
  MEDLINE   92022597
   PUBMED   1925598
REFERENCE   44 (bases 1 to 2312)
  AUTHORS   Bradham,D.M., Igarashi,A., Potter,R.L. and Grotendorst,G.R.
  TITLE     Connective tissue growth factor: a cysteine-rich mitogen secreted
            by human vascular endothelial cells is related to the SRC-induced
            immediate early gene product CEF-10
  JOURNAL   J. Cell Biol. 114 (6), 1285-1294 (1991)
  MEDLINE   91373462
   PUBMED   1654338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X78947.1.
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.1"
     gene            1..2312
                     /gene="CTGF"
                     /note="synonyms: CCN2, NOV2, IGFBP8"
                     /db_xref="GeneID:1490"
                     /db_xref="MIM:121009"
     CDS             146..1195
                     /gene="CTGF"
                     /note="go_component: soluble fraction [goid 0005625]
                     [evidence NR];
                     go_component: extracellular space [goid 0005615] [evidence
                     NR];
                     go_component: plasma membrane [goid 0005886] [evidence
                     TAS] [pmid 10809757];
                     go_component: extracellular matrix (sensu Metazoa) [goid
                     0005578] [evidence TAS] [pmid 10809757];
                     go_function: heparin binding [goid 0008201] [evidence
                     IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: insulin-like growth factor binding [goid
                     0005520] [evidence TAS] [pmid 9371786];
                     go_process: cell motility [goid 0006928] [evidence NR];
                     go_process: cell adhesion [goid 0007155] [evidence IEA];
                     go_process: DNA metabolism [goid 0006259] [evidence IEA];
                     go_process: response to wounding [goid 0009611] [evidence
                     TAS] [pmid 10809757];
                     go_process: epidermis development [goid 0008544] [evidence
                     TAS] [pmid 10809757];
                     go_process: regulation of cell growth [goid 0001558]
                     [evidence IEA];
                     go_process: cell growth and/or maintenance [goid 0008151]
                     [evidence TAS] [pmid 9371786]"
                     /codon_start=1
                     /product="connective tissue growth factor"
                     /protein_id="NP_001892.1"
                     /db_xref="GI:4503123"
                     /db_xref="GeneID:1490"
                     /db_xref="MIM:121009"
                     /translation="MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCP
                     AGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAP
                     CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKC
                     CEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGIS
                     TRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSM
                     KTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDND
                     IFESLYYRKMYGDMA"
     mat_peptide     224..1192
                     /gene="CTGF"
                     /product="connective tissue growth factor"
     polyA_signal    2262..2267
                     /gene="CTGF"
ORIGIN      
        1 tccagtgacg gagccgcccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc
       61 ccacctccga ccaccgccag cgctccaggc cccgcgctcc ccgctcgccg ccaccgcgcc
      121 ctccgctccg cccgcagtgc caaccatgac cgccgccagt atgggccccg tccgcgtcgc
      181 cttcgtggtc ctcctcgccc tctgcagccg gccggccgtc ggccagaact gcagcgggcc
      241 gtgccggtgc ccggacgagc cggcgccgcg ctgcccggcg ggcgtgagcc tcgtgctgga
      301 cggctgcggc tgctgccgcg tctgcgccaa gcagctgggc gagctgtgca ccgagcgcga
      361 cccctgcgac ccgcacaagg gcctcttctg tgacttcggc tccccggcca accgcaagat
      421 cggcgtgtgc accgccaaag atggtgctcc ctgcatcttc ggtggtacgg tgtaccgcag
      481 cggagagtcc ttccagagca gctgcaagta ccagtgcacg tgcctggacg gggcggtggg
      541 ctgcatgccc ctgtgcagca tggacgttcg tctgcccagc cctgactgcc ccttcccgag
      601 gagggtcaag ctgcccggga aatgctgcga ggagtgggtg tgtgacgagc ccaaggacca
      661 aaccgtggtt gggcctgccc tcgcggctta ccgactggaa gacacgtttg gcccagaccc
      721 aactatgatt agagccaact gcctggtcca gaccacagag tggagcgcct gttccaagac
      781 ctgtgggatg ggcatctcca cccgggttac caatgacaac gcctcctgca ggctagagaa
      841 gcagagccgc ctgtgcatgg tcaggccttg cgaagctgac ctggaagaga acattaagaa
      901 gggcaaaaag tgcatccgta ctcccaaaat ctccaagcct atcaagtttg agctttctgg
      961 ctgcaccagc atgaagacat accgagctaa attctgtgga gtatgtaccg acggccgatg
     1021 ctgcaccccc cacagaacca ccaccctgcc ggtggagttc aagtgccctg acggcgaggt
     1081 catgaagaag aacatgatgt tcatcaagac ctgtgcctgc cattacaact gtcccggaga
     1141 caatgacatc tttgaatcgc tgtactacag gaagatgtac ggagacatgg catgaagcca
     1201 gagagtgaga gacattaact cattagactg gaacttgaac tgattcacat ctcatttttc
     1261 cgtaaaaatg atttcagtag cacaagttat ttaaatctgt ttttctaact gggggaaaag
     1321 attcccaccc aattcaaaac attgtgccat gtcaaacaaa tagtctatct tccccagaca
     1381 ctggtttgaa gaatgttaag acttgacagt ggaactacat tagtacacag caccagaatg
     1441 tatattaagg tgtggcttta ggagcagtgg gagggtacca gcagaaaggt tagtatcatc
     1501 agatagctct tatacgagta atatgcctgc tatttgaagt gtaattgaga aggaaaattt
     1561 tagcgtgctc actgacctgc ctgtagcccc agtgacagct aggatgtgca ttctccagcc
     1621 atcaagagac tgagtcaagt tgttccttaa gtcagaacag cagactcagc tctgacattc
     1681 tgattcgaat gacactgttc aggaatcgga atcctgtcga ttagactgga cagcttgtgg
     1741 caagtgaatt tcctgtaaca agccagattt tttaaaattt atattgtaaa tattgtgtgt
     1801 gtgtgtgtgt gtgtatatat atatatatat gtacagttat ctaagttaat ttaaagttgt
     1861 ttgtgccttt ttatttttgt ttttaatgct ttgatatttc aatgttagcc tcaatttctg
     1921 aacaccatag gtagaatgta aagcttgtct gatcgttcaa agcatgaaat ggatacttat
     1981 atggaaattc tctcagatag aatgacagtc cgtcaaaaca gattgtttgc aaaggggagg
     2041 catcagtgtc cttggcaggc tgatttctag gtaggaaatg tggtagctca cgctcacttt
     2101 taatgaacaa atggccttta ttaaaaactg agtgactcta tatagctgat cagttttttc
     2161 acctggaagc atttgtttct actttgatat gactgttttt cggacagttt atttgttgag
     2221 agtgtgacca aaagttacat gtttgcacct ttctagttga aaataaagta tattttttct
     2281 aaaaaaaaaa aaaaacgaca gcaacggaat tc
//

LOCUS       NM_001921               1831 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens dCMP deaminase (DCTD), mRNA.
ACCESSION   NM_001921
VERSION     NM_001921.1  GI:4503276
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Weiner,K.X., Ciesla,J., Jaffe,A.B., Ketring,R., Maley,F. and
            Maley,G.F.
  TITLE     Chromosomal location and structural organization of the human
            deoxycytidylate deaminase gene
  JOURNAL   J. Biol. Chem. 270 (32), 18727-18729 (1995)
   PUBMED   7642519
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Weiner,K.X., Weiner,R.S., Maley,F. and Maley,G.F.
  TITLE     Primary structure of human deoxycytidylate deaminase and
            overexpression of its functional protein in Escherichia coli
  JOURNAL   J. Biol. Chem. 268 (17), 12983-12989 (1993)
   PUBMED   7685356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L12136.1.
            
            Summary: Deoxycytidylate deaminase (DCTD; EC 3.5.4.12) catalyzes
            the deamination of dCMP to dUMP, thus providing the nucleotide
            substrate for thymidylate synthase (MIM 188350). DCTD is
            allosterically activated by dCTP and inhibited by dTTP.[supplied by
            OMIM].
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..1831
                     /gene="DCTD"
                     /db_xref="GeneID:1635"
                     /db_xref="MIM:607638"
     CDS             1..537
                     /gene="DCTD"
                     /EC_number="3.5.4.12"
                     /function="deaminates dCMP to dUMP"
                     /note="go_function: zinc ion binding [goid 0008270]
                     [evidence IEA];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: dCMP deaminase activity [goid 0004132]
                     [evidence TAS] [pmid 7685356];
                     go_process: nucleotide biosynthesis [goid 0009165]
                     [evidence IEA];
                     go_process: pyrimidine nucleotide metabolism [goid
                     0006220] [evidence TAS] [pmid 7685356]"
                     /codon_start=1
                     /product="dCMP deaminase"
                     /protein_id="NP_001912.1"
                     /db_xref="GI:4503277"
                     /db_xref="GeneID:1635"
                     /db_xref="MIM:607638"
                     /translation="MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNS
                     ENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCS
                     MYVALFPCNECAKLIIQAGIKEVIFTSDKYHDSDEATAARLLFNMAGVTFRKFIPKCS
                     KIVIDFDSINSRPSQKLQ"
ORIGIN      
        1 atgagtgaag tttcctgcaa gaaacgggac gactatttgg aatggccaga gtattttatg
       61 gctgtggcct tcttatcagc acagagaagc aaagatccaa attcccaggt cggcgcctgc
      121 atcgtgaatt cagaaaacaa gattgtcggg attgggtaca atgggatgcc aaatgggtgc
      181 agtgatgacg tgttgccttg gagaaggaca gcagagaata agctggacac caaatacccg
      241 tacgtgtgcc atgcggagct gaatgccatc atgaacaaaa attcgaccga tgtgaaaggc
      301 tgtagtatgt atgtcgcctt gttcccttgt aatgaatgcg ctaagctcat catccaggca
      361 ggtataaaag aagtgatttt cacgtctgat aaataccatg atagtgacga ggcaactgct
      421 gcgaggctcc tgtttaatat ggccggggtg acattccgga aattcatacc gaagtgcagc
      481 aagattgtca ttgactttga ttcaattaac agcagaccga gtcaaaagct tcagtgagtt
      541 acatctcatt caatctccag aagattggga ttatcgtctt ctaagaggtt gctaatgcct
      601 ttcatcttga agttacacat aacttcttac tagccagtat ggcaaaagta ggcatctaaa
      661 gaatataaag cctcaaatct tccttactgt ctctcttgtc acatggaatc tacatgtgtt
      721 tgaactattg ctttaggatt taaaataggg gagcctgtgg tggcctggtg cacagggcta
      781 gaacgagagt gcctcccctt cttgtgtcct ggctggctgg gatgctggtg gctcttcaga
      841 ggagcatcag ctgtctgtca tctgctgcga tccggcagcc tctcttcact gctacatgtg
      901 ctggaaggac aaataaataa ttgtggttgt gttcttaatg gggacgagca gacacactga
      961 tctgaacatc tggcccaagt gaagcatggc atatagtgcc cttggaagaa aattaggcct
     1021 caaatgacag tagcattgaa gtgtttgctg cagagttgag ggaaaccccc agccaccctc
     1081 ccggaatccg agatagggtg gcacatctgt cctgacagac gaggagtgta actgaaccag
     1141 gaatatttcc tccattcctg ctctcccact gcacacaggg tggtggcaca ttatccctct
     1201 ggggggtggg gacgcctgtt gttttggctc aatttgggtt tgttggtcac atggagctct
     1261 tccatttcgt ttagctgaat aatgagttgt tcctagagga gacagcctgt ctctccttgt
     1321 tgcccccaaa gcccatgccc tgccgtggtg gcagctgggg ctgtggatgg gaggggtccc
     1381 caacatggat gtgttgcccc tcctccgcat gccaacgcag ttcatgtaca aggcccctct
     1441 gcaactggag agaaaattaa ttcctatccc gtgagtggat tgtgagaaat tccacccacg
     1501 tggagacagc ttactgcagc actgttggtg ttcggagctc ttctgtgccc tggctccatg
     1561 ctttcaccta cacaagcatc accttcctaa tcaccgcggg gcggggagcg tgtggctgtg
     1621 ccccttctct ttaatctcat ttaattttta ttaaacatgc tcagtacctg tgttgagaaa
     1681 aggctttctt tatcctaaag attattacct ttttaaagtg ctcttatatt ttcatgagtt
     1741 tttattttgt ctctgagatt ttgtattcca cattctaggg tattctgtaa tttggctcct
     1801 taccaatatt attaaaatct tattaaaatc t
//

LOCUS       NM_001980               3343 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens epimorphin (EPIM), transcript variant 1, mRNA.
ACCESSION   NM_001980
VERSION     NM_001980.2  GI:37577286
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Kauppi,M., Wohlfahrt,G. and Olkkonen,V.M.
  TITLE     Analysis of the Munc18b-syntaxin binding interface. Use of a mutant
            Munc18b to dissect the functions of syntaxins 2 and 3
  JOURNAL   J. Biol. Chem. 277 (46), 43973-43979 (2002)
   PUBMED   12198139
  REMARK    GeneRIF: Munc18b binds to syntaxins 1A, 2, and 3 and regulates
            vesicle transport to the apical plasma membrane
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Hirai,Y., Lochter,A., Galosy,S., Koshida,S., Niwa,S. and
            Bissell,M.J.
  TITLE     Epimorphin functions as a key morphoregulator for mammary
            epithelial cells
  JOURNAL   J. Cell Biol. 140 (1), 159-169 (1998)
   PUBMED   9425164
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Koshida,S. and Hirai,Y.
  TITLE     Identification of cellular recognition sequence of epimorphin and
            critical role of cell/epimorphin interaction in lung branching
            morphogenesis
  JOURNAL   Biochem. Biophys. Res. Commun. 234 (2), 522-525 (1997)
   PUBMED   9177305
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Zha,H., Remmers,E.F., Szpirer,C., Szpirer,J., Zhang,H., Kozak,C.A.
            and Wilder,R.L.
  TITLE     The epimorphin gene is highly conserved among humans, mice, and
            rats and maps to human chromosome 7, mouse chromosome 5, and rat
            chromosome 12
  JOURNAL   Genomics 37 (3), 386-389 (1996)
   PUBMED   8938452
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Oka,Y. and Hirai,Y.
  TITLE     Inductive influences of epimorphin on endothelial cells in vitro
  JOURNAL   Exp. Cell Res. 222 (1), 189-198 (1996)
   PUBMED   8549663
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Hirai,Y.
  TITLE     Molecular cloning of human epimorphin: identification of isoforms
            and their unique properties
  JOURNAL   Biochem. Biophys. Res. Commun. 191 (3), 1332-1337 (1993)
   PUBMED   8466509
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Hirai,Y., Takebe,K., Takashina,M., Kobayashi,S. and Takeichi,M.
  TITLE     Epimorphin: a mesenchymal protein essential for epithelial
            morphogenesis
  JOURNAL   Cell 69 (3), 471-481 (1992)
   PUBMED   1581962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047496.1.
            On Oct 8, 2003 this sequence version replaced gi:4503586.
            
            Summary: The product of this gene belongs to the
            syntaxin/epimorphin family of proteins. The syntaxins are a large
            protein family implicated in the targeting and fusion of
            intracellular transport vesicles. The product of this gene
            regulates epithelial-mesenchymal interactions and epithelial cell
            morphogenesis and activation. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..3343
                     /gene="EPIM"
                     /note="synonyms: STX2A, STX2B, STX2C, MGC51014"
                     /db_xref="GeneID:2054"
                     /db_xref="MIM:132350"
     CDS             168..1031
                     /gene="EPIM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin 2;
                     go_component: microsome [goid 0005792] [evidence TAS]
                     [pmid 8466509];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: soluble fraction [goid 0005625] [evidence
                     TAS] [pmid 8466509];
                     go_function: protein transporter activity [goid 0008565]
                     [evidence IEA];
                     go_process: organogenesis [goid 0009887] [evidence TAS]
                     [pmid 1581962];
                     go_process: signal transduction [goid 0007165] [evidence
                     TAS] [pmid 1581962];
                     go_process: ectoderm development [goid 0007398] [evidence
                     TAS] [pmid 8466509];
                     go_process: intracellular protein transport [goid 0006886]
                     [evidence IEA]"
                     /codon_start=1
                     /product="epimorphin isoform 1"
                     /protein_id="NP_001971.2"
                     /db_xref="GI:37577287"
                     /db_xref="GeneID:2054"
                     /db_xref="MIM:132350"
                     /translation="MRDRLPDLTACRKNDDGDTVVVVEKDHFMDDFFHQVEEIRNSID
                     KITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIRAKLKAIEQSFDQD
                     ESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRIQRQLEITGRTTT
                     DDELEEMLESGKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDM
                     AMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKLMFIIICVIVLLV
                     ILGIILATTLS"
     polyA_signal    1318..1323
                     /gene="EPIM"
     polyA_site      1339
                     /gene="EPIM"
                     /evidence=experimental
     polyA_signal    3216..3221
                     /gene="EPIM"
     polyA_site      3242
                     /gene="EPIM"
                     /evidence=experimental
     polyA_signal    3309..3314
                     /gene="EPIM"
     polyA_site      3331
                     /gene="EPIM"
ORIGIN      
        1 gcagagcgcg cggggcgcgg ttgccgtggc agcgccggct ccagggaggg ctgctggcgc
       61 cgggccggga ccgcggggcc tgaggcggag accggagagc ccgaggcccg gccggaggca
      121 gctcgggaca ggcttgagcg gcggggcgcg ctgcccggcc ggcggggatg cgggaccggc
      181 tgccagacct gacggcgtgt aggaagaatg atgatggaga cacagttgtt gtggttgaga
      241 aagatcattt catggatgat ttcttccatc aggtggagga gattagaaac agtattgata
      301 aaataactca atatgttgaa gaagtaaaga aaaaccacag catcattctt tctgcaccaa
      361 acccggaagg aaaaataaaa gaagagcttg aagatctgaa caaagaaatc aagaaaactg
      421 cgaataaaat tcgagccaag ttaaaggcta ttgaacaaag ttttgatcag gatgagagtg
      481 ggaaccggac ttcagtggat cttcggatac gaagaaccca gcattcggtg ctgtctcgga
      541 agtttgtgga agccatggcg gagtacaatg aggcacagac tctgtttcgg gagcggagca
      601 aaggccgcat ccagcgccag ctggagataa ctgggagaac caccacagac gacgagctag
      661 aagagatgct ggagagcggg aagccatcca tcttcacttc cgacattata tcagattcac
      721 aaattactag acaagctctc aatgaaatcg agtcacgtca caaggacatc atgaagctgg
      781 agaccagcat ccgagagttg catgagatgt tcatggacat ggctatgttt gtggagactc
      841 agggtgaaat gatcaacaac atagaaagaa atgttatgaa tgccacagac tatgtagaac
      901 acgctaaaga agaaacaaaa aaagctatca aatatcagag caaggcaaga aggaaattga
      961 tgttcattat tatttgtgta attgttttgc ttgtgatcct tggaattatc ctagcaacaa
     1021 cattgtccta gcaaccatat cccaagagcc atttatcctt gagactcaga ccacatctgc
     1081 aaccaaatca gcatcctgtc atttcgtgaa tgaatctcag acgctgtaac ccggcatcga
     1141 gtgctgacct tgtaatgtat gagttcacgg aagaagcaca accgaacgtc ttgttcagtg
     1201 acagcgccgt aagcacagtg ggtgtgatgc gtgaccctga atgacacact acagaatgtg
     1261 agcagtgtga gacttctctc actggccttg aaataagaaa atattgaaca ttttaatatt
     1321 aaaaatattt cagtgttaac aaatgtgcat gaagtttaat taggaaggaa tgctttatgt
     1381 tatgaaggct tttttttttt tttttgagac ggagtctcgc tttgtcatcc aggctggagt
     1441 gcagtggtgc gatctcagct cactgcaacc tcggcctccc gggttcaagc aattctcctg
     1501 cctcagcctc ccgagtagct gggattacag gcatgggcca ccacacccag ctaatttttt
     1561 gtgttttctt tttagtagag acggggtttt accatgctgg ccaggctggc ctcaaactcc
     1621 tgaccttgtg atccacccac ctcagcctcc caaagtgctg ggattacagg cgtgagtcac
     1681 cgggcaggct gttctgaagc ttttagatct caggtctaag gcttcctttc cctccctctc
     1741 ccagctagtt tgtgctaatt aagagacctt ttatactgtt ttattgcctg tttgaagaaa
     1801 taatttttat cacgtttttg taagatatct ataattttaa atgtttataa attgtttaat
     1861 ttattagcat cttaatgtac cccattttta tatactgaat gtggcctttt gagtgaaata
     1921 ggaagcttca tggtgttgga gccacctttg tacagttgtt taaagtttcc cattgtcacg
     1981 gaaaacattg gctgcaaagc ccctcaaagc cctcaagtgc cttctgtgag tttaaatgtg
     2041 ctggtgccct ccagaaaagc ctcggcctca gctccgtttc cgcctgttcc ctcccccagg
     2101 ataatgaatg gttactgcac tgtaaagacc gtggtctctt ttcactaaat aggagattcg
     2161 agtttcccag tttacatgaa tgaagtctga atttaagacg gtgatgaaac tgaggttcag
     2221 tactctcggg actcgaggaa attattcctg agacatggag taattcttac aaatttaaac
     2281 tattgtacag atccacatac atgttgttaa gtacctaatg ttttgctgaa cttttaaaag
     2341 ttaatttcca aaatgtatag ggattcatga taattaaacc tttttattgc tcattttttt
     2401 agtagaagaa tatcacttat ttttagactt gtaaaatgta tgaactggtg agcggacatc
     2461 tgttaagaga gtcactagtc agaatgttaa aggagtgcat gcaggatgcc ccaaatgtcg
     2521 tgaactcttg ttactcctgt atgtagtagt gtaagcatgt gacttttaac accatttggt
     2581 ttgaaactaa tgtagagatg cctgattcca aacaggtgtg gagaatattg aatggctcag
     2641 aagccgcgtc ccttacttaa cacaattccg aatctccctc atccatgatg cgtccattgg
     2701 atcactcgct ggtggtcact gtgtggcagt tactagggga attctgcctc tgactgttct
     2761 ttttcttttg gtctttaaac accctgtcgt gggatgtgct cactgatttg tggctatgtt
     2821 gaaggtatca cttgtcttga gggttttcaa tatttcagga tcatgctggt ggcaaaagga
     2881 ctccacgcct ctgtggaatc atgtccacag ggggacctgc ctcccgtgat gtcccacctt
     2941 tccttcaagg tctgtcatat gagtcctccc cttttacaac acttattatg gtatttttca
     3001 agttattctt cttagatttg cagtacctac tgaaatttgt gtttttatag ttgaagttag
     3061 gaaaatgcta tttgatttgt atttagatat ttaagtcact tgtccaatga tgtgtatgtc
     3121 taagcctcat gtaccgattt gaagtcagac ttaaaaatgt atttacagat tcacttgaga
     3181 ctttttaatc ggttcttcaa atatttcatg tttacattaa aaatttccag agaagcataa
     3241 aagtattcac tttcctgcct tgtcatttct ggaaagattt tggggagata ttttattgca
     3301 tattaattaa taaattgttc tactaggaaa aaaaaaaaaa aaa
//

LOCUS       NM_002211               3700 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens integrin, beta 1 (fibronectin receptor, beta
            polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript
            variant 1A, mRNA.
ACCESSION   NM_002211
VERSION     NM_002211.2  GI:19743812
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3700)
  AUTHORS   Sabri,S., Jandrot-Perrus,M., Bertoglio,J., Farndale,R.W., Mas,V.M.,
            Debili,N. and Vainchenker,W.
  TITLE     Differential regulation of actin stress fiber assembly and
            proplatelet formation by alpha2beta1 integrin and GPVI in human
            megakaryocytes
  JOURNAL   Blood 104 (10), 3117-3125 (2004)
   PUBMED   15265786
  REMARK    GeneRIF: alpha2beta1 integrin and GPVI regulate stress fiber
            formation in megakarocytes, the primary actin structures needed for
            cell contraction
REFERENCE   2  (bases 1 to 3700)
  AUTHORS   Melikova,S., Dylla,S.J. and Verfaillie,C.M.
  TITLE     Phosphatidylinositol-3-kinase activation mediates proline-rich
            tyrosine kinase 2 phosphorylation and recruitment to
            beta1-integrins in human CD34+ cells
  JOURNAL   Exp. Hematol. 32 (11), 1051-1056 (2004)
   PUBMED   15539082
  REMARK    GeneRIF: Activation of PI3K following beta1-integrin engagement on
            human CD34+ cells results in subsequent phosphorylation of PYK2,
            and is required for the recruitment of the PI3K/PYK2 complex to
            beta1-integrins at the cell surface.
REFERENCE   3  (bases 1 to 3700)
  AUTHORS   Enserink,J.M., Price,L.S., Methi,T., Mahic,M., Sonnenberg,A.,
            Bos,J.L. and Task.
  TITLE     The cAMP-Epac-Rap1 pathway regulates cell spreading and cell
            adhesion to laminin-5 through the alpha3beta1 integrin but not the
            alpha6beta4 integrin
  JOURNAL   J. Biol. Chem. 279 (43), 44889-44896 (2004)
   PUBMED   15302884
  REMARK    GeneRIF: cAMP-Epac-Rap1 pathway regulates cell spreading and cell
            adhesion to laminin-5 through the alpha3beta1 integrin but not the
            alpha6beta4 integrin
REFERENCE   4  (bases 1 to 3700)
  AUTHORS   Baronas-Lowell,D., Lauer-Fields,J.L., Borgia,J.A., Sferrazza,G.F.,
            Al-Ghoul,M., Minond,D. and Fields,G.B.
  TITLE     Differential modulation of human melanoma cell metalloproteinase
            expression by alpha2beta1 integrin and CD44 triple-helical ligands
            derived from type IV collagen
  JOURNAL   J. Biol. Chem. 279 (42), 43503-43513 (2004)
   PUBMED   15292257
  REMARK    GeneRIF: alpha2beta1 integrin and CD44/CSPG receptor binding on
            human melanoma cell activation has been evaluated herein using
            triple-helical peptide ligands incorporating collagen peptides.
REFERENCE   5  (bases 1 to 3700)
  AUTHORS   Brittain,J.E., Han,J., Ataga,K.I., Orringer,E.P. and Parise,L.V.
  TITLE     Mechanism of CD47-induced alpha4beta1 integrin activation and
            adhesion in sickle reticulocytes
  JOURNAL   J. Biol. Chem. 279 (41), 42393-42402 (2004)
   PUBMED   15292185
  REMARK    GeneRIF: alpha4beta1 integrin on sickle reticulocytes is a
            CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin
REFERENCE   6  (bases 1 to 3700)
  AUTHORS   Zwartz,G.J., Chigaev,A., Dwyer,D.C., Foutz,T.D., Edwards,B.S. and
            Sklar,L.A.
  TITLE     Real-time analysis of very late antigen-4 affinity modulation by
            shear
  JOURNAL   J. Biol. Chem. 279 (37), 38277-38286 (2004)
   PUBMED   15226304
  REMARK    GeneRIF: very late antigen-4 affinity is modulated by shear
REFERENCE   7  (bases 1 to 3700)
  AUTHORS   Majumdar,M., Tarui,T., Shi,B., Akakura,N., Ruf,W. and Takada,Y.
  TITLE     Plasmin-induced migration requires signaling through
            protease-activated receptor 1 and integrin alpha(9)beta(1)
  JOURNAL   J. Biol. Chem. 279 (36), 37528-37534 (2004)
   PUBMED   15247268
  REMARK    GeneRIF: role in chemotaxis in conjuction with plasmin
REFERENCE   8  (bases 1 to 3700)
  AUTHORS   Lishko,V.K., Novokhatny,V.V., Yakubenko,V.P.,
            Skomorovska-Prokvolit,H.V. and Ugarova,T.P.
  TITLE     Characterization of plasminogen as an adhesive ligand for integrins
            alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5)
  JOURNAL   Blood 104 (3), 719-726 (2004)
   PUBMED   15090462
  REMARK    GeneRIF: findings identify Glu-Pg as an adhesive ligand for
            integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1
            may participate in the binding of soluble Glu-Pg and assist in its
            activation.
REFERENCE   9  (bases 1 to 3700)
  AUTHORS   Chigaev,A., Zwartz,G.J., Buranda,T., Edwards,B.S., Prossnitz,E.R.
            and Sklar,L.A.
  TITLE     Conformational regulation of alpha 4 beta 1-integrin affinity by
            reducing agents. 'Inside-out' signaling is independent of and
            additive to reduction-regulated integrin activation
  JOURNAL   J. Biol. Chem. 279 (31), 32435-32443 (2004)
   PUBMED   15166232
  REMARK    GeneRIF: conformational activation of VLA-4 by inside-out signaling
            is independent of and additive to reduction-regulated integrin
            activation
REFERENCE   10 (bases 1 to 3700)
  AUTHORS   Bix,G., Fu,J., Gonzalez,E.M., Macro,L., Barker,A., Campbell,S.,
            Zutter,M.M., Santoro,S.A., Kim,J.K., H, Reed,C.C. and Iozzo,R.V.
  TITLE     Endorepellin causes endothelial cell disassembly of actin
            cytoskeleton and focal adhesions through alpha2beta1 integrin
  JOURNAL   J. Cell Biol. 166 (1), 97-109 (2004)
   PUBMED   15240572
  REMARK    GeneRIF: alpha2beta1 integrin has a role in endorepellin-induced
            endothelial cell disassembly of actin cytoskeleton and focal
            adhesions
REFERENCE   11 (bases 1 to 3700)
  AUTHORS   Samson,T., Smyth,N., Janetzky,S., Wendler,O., M, Sch, von der
            Mark,H., von der Mark,K. and Wixler,V.
  TITLE     The LIM-only proteins FHL2 and FHL3 interact with alpha- and
            beta-subunits of the muscle alpha7beta1 integrin receptor
  JOURNAL   J. Biol. Chem. 279 (27), 28641-28652 (2004)
   PUBMED   15117962
  REMARK    GeneRIF: FHL2 and FHL3, respectively, are colocalized with
            alpha(7)beta(1) integrin receptor at the periphery of Z-discs,
            suggesting a role in mechanical stabilization of muscle cells
REFERENCE   12 (bases 1 to 3700)
  AUTHORS   Cheng,Q., Ross,R.S. and Walsh,K.B.
  TITLE     Overexpression of the integrin beta(1A) subunit and the beta(1A)
            cytoplasmic domain modifies the beta-adrenergic regulation of the
            cardiac L-type Ca(2+)current
  JOURNAL   J. Mol. Cell. Cardiol. 36 (6), 809-819 (2004)
   PUBMED   15158122
  REMARK    GeneRIF: Overexpression of integrin beta(1)modifies the response of
            I(Ca)to beta-adrenergic receptor stimulation.
REFERENCE   13 (bases 1 to 3700)
  AUTHORS   Bax,D.V., Messent,A.J., Tart,J., van Hoang,M., Kott,J.,
            Maciewicz,R.A. and Humphries,M.J.
  TITLE     Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize
            in migrating HeLa cells
  JOURNAL   J. Biol. Chem. 279 (21), 22377-22386 (2004)
   PUBMED   14970227
  REMARK    GeneRIF: Integrin alpha5beta1 and ADAM-17 interact in vitro and
            co-localize in migrating HeLa cells
REFERENCE   14 (bases 1 to 3700)
  AUTHORS   Cheuk,B.L. and Cheng,S.W.
  TITLE     Differential expression of integrin alpha5beta1 in human abdominal
            aortic aneurysm and healthy aortic tissues and its significance in
            pathogenesis
  JOURNAL   J. Surg. Res. 118 (2), 176-182 (2004)
   PUBMED   15100006
  REMARK    GeneRIF: The marked decrease in integrin alpha5beta1 expressions
            was unique to aneurysmal aortic tissues and correlated to a
            decrease in density of smooth muscle cells
REFERENCE   15 (bases 1 to 3700)
  AUTHORS   Isaji,T., Gu,J., Nishiuchi,R., Zhao,Y., Takahashi,M., Miyoshi,E.,
            Honke,K., Sekiguchi,K. and Taniguchi,N.
  TITLE     Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces
            ligand binding and down-regulates cell adhesion and cell migration
  JOURNAL   J. Biol. Chem. 279 (19), 19747-19754 (2004)
   PUBMED   14998999
  REMARK    GeneRIF: beta1,4-N-acetylglucosaminyltransferase III inhibits the
            function of alpha5beta1 integrin
REFERENCE   16 (bases 1 to 3700)
  AUTHORS   Kaido,T., Perez,B., Yebra,M., Hill,J., Cirulli,V., Hayek,A. and
            Montgomery,A.M.
  TITLE     Alphav-integrin utilization in human beta-cell adhesion, spreading,
            and motility
  JOURNAL   J. Biol. Chem. 279 (17), 17731-17737 (2004)
   PUBMED   14766759
  REMARK    GeneRIF: alpha(v)beta(1) supports fetal beta-cell migration and
            could play an important role in early motile processes required for
            islet neogenesis
REFERENCE   17 (bases 1 to 3700)
  AUTHORS   Kolesnikova,T.V., Stipp,C.S., Rao,R.M., Lane,W.S., Luscinskas,F.W.
            and Hemler,M.E.
  TITLE     EWI-2 modulates lymphocyte integrin alpha4beta1 functions
  JOURNAL   Blood 103 (8), 3013-3019 (2004)
   PUBMED   15070678
  REMARK    GeneRIF: EWI-2-dependent reorganization of alpha4beta1-CD81
            complexes on the cell surface is responsible for EWI-2 effects on
            integrin-dependent morphology and motility functions
REFERENCE   18 (bases 1 to 3700)
  AUTHORS   Wang,H., Fu,W., Im,J.H., Zhou,Z., Santoro,S.A., Iyer,V.,
            DiPersio,C.M., Yu,Q.C., Quaranta,V., Al-Mehdi,A. and Muschel,R.J.
  TITLE     Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate
            pulmonary arrest and metastasis
  JOURNAL   J. Cell Biol. 164 (6), 935-941 (2004)
   PUBMED   15024036
  REMARK    GeneRIF: Data suggest that the early arrest of tumor cells in the
            pulmonary vasculature through interaction of alpha3beta1 integrin
            with laminin-5 in exposed basement membrane provides a basis for
            cell arrest during pulmonary metastasis.
REFERENCE   19 (bases 1 to 3700)
  AUTHORS   Salicioni,A.M., Gaultier,A., Brownlee,C., Cheezum,M.K. and
            Gonias,S.L.
  TITLE     Low density lipoprotein receptor-related protein-1 promotes beta1
            integrin maturation and transport to the cell surface
  JOURNAL   J. Biol. Chem. 279 (11), 10005-10012 (2004)
   PUBMED   14699139
  REMARK    GeneRIF: beta1 integrin maturation and transport to the cell
            surface is regulated by low density lipoprotein receptor-related
            protein-1
REFERENCE   20 (bases 1 to 3700)
  AUTHORS   Calzada,M.J., Zhou,L., Sipes,J.M., Zhang,J., Krutzsch,H.C.,
            Iruela-Arispe,M.L., Annis,D.S., Mosher,D.F. and Roberts,D.D.
  TITLE     Alpha4beta1 integrin mediates selective endothelial cell responses
            to thrombospondins 1 and 2 in vitro and modulates angiogenesis in
            vivo
  JOURNAL   Circ. Res. 94 (4), 462-470 (2004)
   PUBMED   14699013
  REMARK    GeneRIF: Alpha4beta1 is an important endothelial cell receptor for
            mediating motility and proliferative responses to thrombospondins
            and for modulation of angiogenesis.
REFERENCE   21 (bases 1 to 3700)
  AUTHORS   Conant,K., St Hillaire,C., Nagase,H., Visse,R., Gary,D.,
            Haughey,N., Anderson,C., Turchan,J. and Nath,A.
  TITLE     Matrix metalloproteinase 1 interacts with neuronal integrins and
            stimulates dephosphorylation of Akt
  JOURNAL   J. Biol. Chem. 279 (9), 8056-8062 (2004)
   PUBMED   14679206
  REMARK    GeneRIF: results suggest that matrix metalloproteinase-1 can
            stimulate dephosphorylation of Akt protein and neuronal death
            through a non-proteolytic mechanism that involves changes in
            integrin alpha2beta1 signaling
REFERENCE   22 (bases 1 to 3700)
  AUTHORS   Yang,W., Shimaoka,M., Chen,J. and Springer,T.A.
  TITLE     Activation of integrin beta-subunit I-like domains by one-turn
            C-terminal alpha-helix deletions
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (8), 2333-2338 (2004)
   PUBMED   14983010
  REMARK    GeneRIF: beta I-like and alpha I domain activation involves
            structurally analogous alpha7-helix axial displacements.
REFERENCE   23 (bases 1 to 3700)
  AUTHORS   Siljander,P.R., Munnix,I.C., Smethurst,P.A., Deckmyn,H.,
            Lindhout,T., Ouwehand,W.H., Farndale,R.W. and Heemskerk,J.W.
  TITLE     Platelet receptor interplay regulates collagen-induced thrombus
            formation in flowing human blood
  JOURNAL   Blood 103 (4), 1333-1341 (2004)
   PUBMED   14563646
  REMARK    GeneRIF: human platelet deposition on collagen depends on the
            concerted interplay of several receptors: GPIb in synergy with
            alpha(2)beta(1) mediating primary adhesion, reinforced by
            activation through GPVI, which further regulates the thrombus
            formation.
REFERENCE   24 (bases 1 to 3700)
  AUTHORS   K, Pohlentz,G., Schmidt-Hederich,A., Odenthal,U., Smyth,N.,
            Peter-Katalinic,J., Bruckner,P. and Eble,J.A.
  TITLE     Recombinant human laminin-5 domains. Effects of
            heterotrimerization, proteolytic processing, and N-glycosylation on
            alpha3beta1 integrin binding
  JOURNAL   J. Biol. Chem. 279 (7), 5184-5193 (2004)
   PUBMED   14612440
  REMARK    GeneRIF: alpha3beta1 integrin binding to laminin-5 depends on its
            proteolytic processing
REFERENCE   25 (bases 1 to 3700)
  AUTHORS   Boudreau,N.J. and Varner,J.A.
  TITLE     The homeobox transcription factor Hox D3 promotes integrin
            alpha5beta1 expression and function during angiogenesis
  JOURNAL   J. Biol. Chem. 279 (6), 4862-4868 (2004)
   PUBMED   14610084
  REMARK    GeneRIF: Hox D3 coordinately regulates the expression of integrin
            alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo.
REFERENCE   26 (bases 1 to 3700)
  AUTHORS   Chen,J., De,S., Brainard,J. and Byzova,T.V.
  TITLE     Metastatic properties of prostate cancer cells are controlled by
            VEGF
  JOURNAL   Cell Commun. Adhes. 11 (1), 1-11 (2004)
  MEDLINE   23614367
   PUBMED   15500293
  REMARK    GeneRIF: The integrin, beta 1 was expressed by prostate cancer
            cells in vitro and by prostate tumors in vivo, and their expression
            was elevated at sites of bone metastasis compared to original
            prostate tumor.
REFERENCE   27 (bases 1 to 3700)
  AUTHORS   Powelka,A.M., Sun,J., Li,J., Gao,M., Shaw,L.M., Sonnenberg,A. and
            Hsu,V.W.
  TITLE     Stimulation-dependent recycling of integrin beta1 regulated by ARF6
            and Rab11
  JOURNAL   Traffic 5 (1), 20-36 (2004)
   PUBMED   14675422
  REMARK    GeneRIF: Data show that stimulation-dependent recycling of integrin
            beta1 is regulated by ARF6 and Rab11, and also requires the actin
            cytoskeleton in an ARF6-dependent manner.
REFERENCE   28 (bases 1 to 3700)
  AUTHORS   Sullivan,G.W., Lee,D.D., Ross,W.G., DiVietro,J.A., Lappas,C.M.,
            Lawrence,M.B. and Linden,J.
  TITLE     Activation of A2A adenosine receptors inhibits expression of alpha
            4/beta 1 integrin (very late antigen-4) on stimulated human
            neutrophils
  JOURNAL   J. Leukoc. Biol. 75 (1), 127-134 (2004)
   PUBMED   14525968
  REMARK    GeneRIF: following priming of human neutrophils with
            lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha),
            addition of formyl-Met-Leu-Phe (fMLP) results in a 'stimulated',
            sepsis-like, four- to fivefold rise in CD49d expression
REFERENCE   29 (bases 1 to 3700)
  AUTHORS   Stipp,C.S., Kolesnikova,T.V. and Hemler,M.E.
  TITLE     EWI-2 regulates alpha3beta1 integrin-dependent cell functions on
            laminin-5
  JOURNAL   J. Cell Biol. 163 (5), 1167-1177 (2003)
   PUBMED   14662754
  REMARK    GeneRIF: results show how laterally associated EWI-2 might regulate
            alpha3beta1 function in disease and development, and demonstrate
            how tetraspanin proteins can assemble multiple nontetraspanin
            proteins into functional complexes
REFERENCE   30 (bases 1 to 3700)
  AUTHORS   Wang,X.Q., Sun,P. and Paller,A.S.
  TITLE     Ganglioside GM3 blocks the activation of epidermal growth factor
            receptor induced by integrin at specific tyrosine sites
  JOURNAL   J. Biol. Chem. 278 (49), 48770-48778 (2003)
   PUBMED   14512423
  REMARK    GeneRIF: role in ganglioside GM3 blocking of epidermal growth
            factor receptor
REFERENCE   31 (bases 1 to 3700)
  AUTHORS   Weigel-Kelley,K.A., Yoder,M.C. and Srivastava,A.
  TITLE     Alpha5beta1 integrin as a cellular coreceptor for human parvovirus
            B19: requirement of functional activation of beta1 integrin for
            viral entry
  JOURNAL   Blood 102 (12), 3927-3933 (2003)
   PUBMED   12907437
  REMARK    GeneRIF: upon treatment with phorbol esters, K562 cells become
            adherent and permissive for parvovirus B19 entry, which is mediated
            by alpha 5 beta 1 integrins, but only in their high-affinity
            conformation
REFERENCE   32 (bases 1 to 3700)
  AUTHORS   Salone,B., Martina,Y., Piersanti,S., Cundari,E., Cherubini,G.,
            Franqueville,L., Failla,C.M., Boulanger,P. and Saggio,I.
  TITLE     Integrin alpha3beta1 is an alternative cellular receptor for
            adenovirus serotype 5
  JOURNAL   J. Virol. 77 (24), 13448-13454 (2003)
   PUBMED   14645603
  REMARK    GeneRIF: results suggest that a direct interaction occurs between
            the Adenovirus penton base protein and the integrin receptor
            alpha3beta1 in vitro and in vivo
REFERENCE   33 (bases 1 to 3700)
  AUTHORS   Lovecchio,M., Maiorano,E., Vacca,R.A., Loverro,G., Fanelli,M.,
            Resta,L., Stefanelli,S., Selvaggi,L., Marra,E. and Perlino,E.
  TITLE     beta 1C Integrin expression in human endometrial proliferative
            diseases
  JOURNAL   Am. J. Pathol. 163 (6), 2543-2553 (2003)
  MEDLINE   22994466
   PUBMED   14633626
  REMARK    GeneRIF: Key role of the regulation of beta 1C integrin expression
            in the pathogenesis of endometrial proliferative diseases: beta 1C
            integrin may act as growth modulator in cancer cells, playing a
            role in downstream intracellular signaling.
REFERENCE   34 (bases 1 to 3700)
  AUTHORS   Moro,L., Greco,M., Ditonno,P., Battaglia,M., Marra,E. and
            Perlino,E.
  TITLE     Transcriptional regulation of the beta1C integrin splice variant in
            human prostate adenocarcinoma
  JOURNAL   Int. J. Oncol. 23 (6), 1601-1606 (2003)
  MEDLINE   22974157
   PUBMED   14612932
  REMARK    GeneRIF: beta1C integrin splice variant is transcriptionally
            regulated in human prostate adenocarcinoma
REFERENCE   35 (bases 1 to 3700)
  AUTHORS   de la Fuente,M.T., Casanova,B., Cantero,E., Hern, Garcia-Marco,J.,
            Silva,A. and Garcia-Pardo,A.
  TITLE     Involvement of p53 in alpha4beta1 integrin-mediated resistance of
            B-CLL cells to fludarabine
  JOURNAL   Biochem. Biophys. Res. Commun. 311 (3), 708-712 (2003)
  MEDLINE   22984513
   PUBMED   14623330
  REMARK    GeneRIF: integrin alpha4beta1 is induced by p53 and has a role in
            B-cell chronic lymphocytic leukemia drug resistance
REFERENCE   36 (bases 1 to 3700)
  AUTHORS   Nakayamada,S., Okada,Y., Saito,K., Tamura,M. and Tanaka,Y.
  TITLE     Beta1 integrin/focal adhesion kinase-mediated signaling induces
            intercellular adhesion molecule 1 and receptor activator of nuclear
            factor kappaB ligand on osteoblasts and osteoclast maturation
  JOURNAL   J. Biol. Chem. 278 (46), 45368-45374 (2003)
  MEDLINE   22970065
   PUBMED   12954625
  REMARK    GeneRIF: beta1 integrin/FAK-mediated signaling on osteoblasts could
            be involved in ICAM-1- and RANKL-dependent osteoclast maturation
REFERENCE   37 (bases 1 to 3700)
  AUTHORS   Yebra,M., Montgomery,A.M., Diaferia,G.R., Kaido,T., Silletti,S.,
            Perez,B., Just,M.L., Hildbrand,S., Hurford,R., Florkiewicz,E.,
            Tessier-Lavigne,M. and Cirulli,V.
  TITLE     Recognition of the neural chemoattractant Netrin-1 by integrins
            alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and
            migration
  JOURNAL   Dev. Cell 5 (5), 695-707 (2003)
  MEDLINE   22964546
   PUBMED   14602071
  REMARK    GeneRIF: Data demonstrate that alpha6beta4 integrin mediates
            pancreatic epithelial cell adhesion to Netrin-1, whereas
            recruitment of alpha6beta4 and alpha3beta1 regulate the migration
            of putative pancreatic progenitors on Netrin-1.
REFERENCE   38 (bases 1 to 3700)
  AUTHORS   Suzuki,K. and Takahashi,K.
  TITLE     Reduced expression of the regulatory A subunit of serine/threonine
            protein phosphatase 2A in human breast cancer MCF-7 cells
  JOURNAL   Int. J. Oncol. 23 (5), 1263-1268 (2003)
  MEDLINE   22894491
   PUBMED   14532964
  REMARK    GeneRIF: the failure of beta1 integrin dephosphorylation at
            threonines 788 and 789 may be due to a significant reduction in the
            PP2A-A expression in tumor cells
REFERENCE   39 (bases 1 to 3700)
  AUTHORS   Suzuki,K. and Takahashi,K.
  TITLE     Reduced cell adhesion during mitosis by threonine phosphorylation
            of beta1 integrin
  JOURNAL   J. Cell. Physiol. 197 (2), 297-305 (2003)
  MEDLINE   22863231
   PUBMED   14502569
  REMARK    GeneRIF: Reduced beta1 integrin-mediated cell adhesion of HME cells
            to the substratum during mitosis may be induced by beta1 integrin
            phosphorylation at threonines 788-789 and its reduced ability to
            link with the actin cytoskeleton.
REFERENCE   40 (bases 1 to 3700)
  AUTHORS   Moiseeva,E.P., Williams,B., Goodall,A.H. and Samani,N.J.
  TITLE     Galectin-1 interacts with beta-1 subunit of integrin
  JOURNAL   Biochem. Biophys. Res. Commun. 310 (3), 1010-1016 (2003)
  MEDLINE   22898163
   PUBMED   14550305
  REMARK    GeneRIF: integrin beta1 interacts with galectin 1
REFERENCE   41 (bases 1 to 3700)
  AUTHORS   Agerer,F., Michel,A., Ohlsen,K. and Hauck,C.R.
  TITLE     Integrin-mediated invasion of Staphylococcus aureus into human
            cells requires Src family protein-tyrosine kinases
  JOURNAL   J. Biol. Chem. 278 (43), 42524-42531 (2003)
  MEDLINE   22928087
   PUBMED   12893831
  REMARK    GeneRIF: identify intracellular signals involved in integrin
            BETA1-initiated internalization of S. aureus
REFERENCE   42 (bases 1 to 3700)
  AUTHORS   Calzada,M.J., Sipes,J.M., Krutzsch,H.C., Yurchenco,P.D.,
            Annis,D.S., Mosher,D.F. and Roberts,D.D.
  TITLE     Recognition of the N-terminal modules of thrombospondin-1 and
            thrombospondin-2 by alpha6beta1 integrin
  JOURNAL   J. Biol. Chem. 278 (42), 40679-40687 (2003)
  MEDLINE   22917493
   PUBMED   12909644
  REMARK    GeneRIF: alpha6beta1 integrins have roles as thrombospondin
            receptors in microvascular and large vessel endothelial cells
REFERENCE   43 (bases 1 to 3700)
  AUTHORS   Seales,E.C., Jurado,G.A., Singhal,A. and Bellis,S.L.
  TITLE     Ras oncogene directs expression of a differentially sialylated,
            functionally altered beta1 integrin
  JOURNAL   Oncogene 22 (46), 7137-7145 (2003)
  MEDLINE   22924014
   PUBMED   14562042
  REMARK    GeneRIF: Ras oncogene directs expression of a differentially
            sialylated, functionally altered beta1 integrin.
REFERENCE   44 (bases 1 to 3700)
  AUTHORS   Mould,A.P., Symonds,E.J., Buckley,P.A., Grossmann,J.G.,
            McEwan,P.A., Barton,S.J., Askari,J.A., Craig,S.E., Bella,J. and
            Humphries,M.J.
  TITLE     Structure of an integrin-ligand complex deduced from solution x-ray
            scattering and site-directed mutagenesis
  JOURNAL   J. Biol. Chem. 278 (41), 39993-39999 (2003)
  MEDLINE   22890199
   PUBMED   12871973
  REMARK    GeneRIF: visualized the head region of integrin alpha 5 beta 1 in
            an inactive (Ca2+-occupied) state, and in complex with a fragment
            of fibronectin containing the RGD and synergy recognition sequences
REFERENCE   45 (bases 1 to 3700)
  AUTHORS   Chigaev,A., Zwartz,G., Graves,S.W., Dwyer,D.C., Tsuji,H.,
            Foutz,T.D., Edwards,B.S., Prossnitz,E.R., Larson,R.S. and
            Sklar,L.A.
  TITLE     Alpha4beta1 integrin affinity changes govern cell adhesion
  JOURNAL   J. Biol. Chem. 278 (40), 38174-38182 (2003)
  MEDLINE   22877031
   PUBMED   12844491
  REMARK    GeneRIF: Alpha4beta1 integrin has a role in cell adhesion
REFERENCE   46 (bases 1 to 3700)
  AUTHORS   Nishiuchi,R., Murayama,O., Fujiwara,H., Gu,J., Kawakami,T.,
            Aimoto,S., Wada,Y. and Sekiguchi,K.
  TITLE     Characterization of the ligand-binding specificities of integrin
            alpha3beta1 and alpha6beta1 using a panel of purified laminin
            isoforms containing distinct alpha chains
  JOURNAL   J. Biochem. 134 (4), 497-504 (2003)
  MEDLINE   22969956
   PUBMED   14607975
  REMARK    GeneRIF: ligand-binding specificities of integrin alpha3beta1 and
            alpha6beta1
REFERENCE   47 (bases 1 to 3700)
  AUTHORS   Plan, Du Merle,L., Le Friec,S., Gounon,P., Jouve,M., Guignot,J.,
            Servin,A. and Le,Bougu.
  TITLE     Recognition of the cellular beta1-chain integrin by the bacterial
            AfaD invasin is implicated in the internalization of afa-expressing
            pathogenic Escherichia coli strains
  JOURNAL   Cell. Microbiol. 5 (10), 681-693 (2003)
  MEDLINE   22849903
   PUBMED   12969374
  REMARK    GeneRIF: results suggest that beta1 integrin is a common receptor
            for AfaD invasins and that additional AfaD-type-specific receptors
            exist
REFERENCE   48 (bases 1 to 3700)
  AUTHORS   Takagi,J., Strokovich,K., Springer,T.A. and Walz,T.
  TITLE     Structure of integrin alpha5beta1 in complex with fibronectin
  JOURNAL   EMBO J. 22 (18), 4607-4615 (2003)
  MEDLINE   22850108
   PUBMED   12970173
  REMARK    GeneRIF: The structural conformation of this protein, complexed
            wigh integrin alpha5, complexed with fibronectin, is examined
REFERENCE   49 (bases 1 to 3700)
  AUTHORS   Lahav,J., Wijnen,E.M., Hess,O., Hamaia,S.W., Griffiths,D.,
            Makris,M., Knight,C.G., Essex,D.W. and Farndale,R.W.
  TITLE     Enzymatically catalyzed disulfide exchange is required for platelet
            adhesion to collagen via integrin alpha2beta1
  JOURNAL   Blood 102 (6), 2085-2092 (2003)
  MEDLINE   22840685
   PUBMED   12791669
  REMARK    GeneRIF: adhesion to the alpha2beta1-specific peptide was
            disulfide-exchange dependent and protein disulfide isomerase (PDI)
            mediated in platelets
REFERENCE   50 (bases 1 to 3700)
  AUTHORS   Leu,S.J., Liu,Y., Chen,N., Chen,C.C., Lam,S.C. and Lau,L.F.
  TITLE     Identification of a novel integrin alpha 6 beta 1 binding site in
            the angiogenic inducer CCN1 (CYR61)
  JOURNAL   J. Biol. Chem. 278 (36), 33801-33808 (2003)
  MEDLINE   22829990
   PUBMED   12826661
  REMARK    GeneRIF: integrin alpha 6 beta 1 binds to CCN1
REFERENCE   51 (bases 1 to 3700)
  AUTHORS   Bax,D.V., Bernard,S.E., Lomas,A., Morgan,A., Humphries,J.,
            Shuttleworth,C.A., Humphries,M.J. and Kielty,C.M.
  TITLE     Cell adhesion to fibrillin-1 molecules and microfibrils is mediated
            by alpha 5 beta 1 and alpha v beta 3 integrins
  JOURNAL   J. Biol. Chem. 278 (36), 34605-34616 (2003)
  MEDLINE   22829896
   PUBMED   12807887
  REMARK    GeneRIF: alpha 5 beta 1 and alpha v beta 3 are both important but
            cell-specific fibrillin-1 receptors
REFERENCE   52 (bases 1 to 3700)
  AUTHORS   Orecchia,A., Lacal,P.M., Schietroma,C., Morea,V., Zambruno,G. and
            Failla,C.M.
  TITLE     Vascular endothelial growth factor receptor-1 is deposited in the
            extracellular matrix by endothelial cells and is a ligand for the
            alpha 5 beta 1 integrin
  JOURNAL   J. Cell. Sci. 116 (Pt 17), 3479-3489 (2003)
  MEDLINE   22775532
   PUBMED   12865438
  REMARK    GeneRIF: VEGFR-1 secreted by endothelial cells interacts with the
            alpha 5 beta 1 integrin
REFERENCE   53 (bases 1 to 3700)
  AUTHORS   Londrigan,S.L., Graham,K.L., Takada,Y., Halasz,P. and Coulson,B.S.
  TITLE     Monkey rotavirus binding to alpha2beta1 integrin requires the
            alpha2 I domain and is facilitated by the homologous beta1 subunit
  JOURNAL   J. Virol. 77 (17), 9486-9501 (2003)
  MEDLINE   22797157
   PUBMED   12915563
  REMARK    GeneRIF: Monkey rotavirus binding to alpha2beta1 integrin requires
            the alpha2 I domain and is facilitated by the homologous beta1
            subunit.
REFERENCE   54 (bases 1 to 3700)
  AUTHORS   Kossiva,L., Paterakis,G., Tassiopoulos,S., Papadhimitriou,S.I.,
            Voukouti,E., Gligori,I. and Rombos,Y.
  TITLE     Decreased expression of membrane alpha4beta1, alpha5beta1 integrins
            and transferrin receptor on erythroblasts in splenectomized
            patients with beta-thalassemia intermedia. Parallel assessment of
            serum soluble transferrin receptors levels
  JOURNAL   Ann. Hematol. 82 (9), 579-584 (2003)
  MEDLINE   22866202
   PUBMED   12904899
  REMARK    GeneRIF: in beta-thalassemic patients, significant reduction of
            CD49d, CD29 and CD71 antigen expression was found in peripheral
            blood nucleated red cells
REFERENCE   55 (bases 1 to 3700)
  AUTHORS   Podolnikova,N.P., Yakubenko,V.P., Volkov,G.L., Plow,E.F. and
            Ugarova,T.P.
  TITLE     Identification of a novel binding site for platelet integrins alpha
            IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of
            fibrinogen
  JOURNAL   J. Biol. Chem. 278 (34), 32251-32258 (2003)
  MEDLINE   22803367
   PUBMED   12799374
  REMARK    GeneRIF: identification of binding site in gamma C-domain of
            fibrinogen
REFERENCE   56 (bases 1 to 3700)
  AUTHORS   Sweeney,S.M., DiLullo,G., Slater,S.J., Martinez,J., Iozzo,R.V.,
            Lauer-Fields,J.L., Fields,G.B. and San Antonio,J.D.
  TITLE     Angiogenesis in collagen I requires alpha2beta1 ligation of a
            GFP*GER sequence and possibly p38 MAPK activation and focal
            adhesion disassembly
  JOURNAL   J. Biol. Chem. 278 (33), 30516-30524 (2003)
  MEDLINE   22791706
   PUBMED   12788934
  REMARK    GeneRIF: capillary morphogenesis requires endothelial alpha2beta1
            integrin engagement of a single type I collagen integrin-binding
            site, possibly signaling via p38 MAPK and focal adhesion
            disassembly/FAK inactivation.
REFERENCE   57 (bases 1 to 3700)
  AUTHORS   Da Silva,M.S., Siddiqui,J., Halverson,A., Wilasrusmee,C., Bruch,D.
            and Kittur,D.S.
  TITLE     beta1-integrin-ligand disengagement induces in vitro capillary tube
            disruption mediated by p38 MAPK activity
  JOURNAL   Surgery 134 (2), 164-168 (2003)
  MEDLINE   22828145
   PUBMED   12947314
  REMARK    GeneRIF: The beta1-integrin-ligand disengagement resulted in
            capillary disruption and stimulated p38 MAPK and extracellular
            signal-regulated kinase activity.
REFERENCE   58 (bases 1 to 3700)
  AUTHORS   Santoro,M.M., Gaudino,G. and Marchisio,P.C.
  TITLE     The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins
            via 14-3-3 proteins in keratinocyte migration
  JOURNAL   Dev. Cell 5 (2), 257-271 (2003)
  MEDLINE   22800579
   PUBMED   12919677
  REMARK    GeneRIF: Data show that macrophage stimulating protein (MSP) and
            its receptor (Ron) induce phosphorylation of both Ron and
            alpha6beta4 integrin, and result in activation of alpha3beta1
            integrin.
REFERENCE   59 (bases 1 to 3700)
  AUTHORS   Liang,Y.L., Lei,T.W., Wu,H., Su,J.M., Wang,L.Y., Lei,Q.Y. and
            Zha,X.L.
  TITLE     S-phase delay in human hepatocellular carcinoma cells induced by
            overexpression of integrin beta1
  JOURNAL   World J. Gastroenterol. 9 (8), 1689-1696 (2003)
  MEDLINE   22799378
   PUBMED   12918102
  REMARK    GeneRIF: S-phase delay induced by overexpression of integrin beta1
            subunit caused by decrease of protein kinase B phosphorylation and
            subsequent increases of p21(cip1) and p27(kip1) proteins. May be
            involved in unoccupied alpha5beta1 because of lack of ligands.
REFERENCE   60 (bases 1 to 3700)
  AUTHORS   Davidson,B., Goldberg,I., Reich,R., Tell,L., Dong,H.P.,
            Trope',C.G., Risberg,B. and Kopolovic,J.
  TITLE     AlphaV- and beta1-integrin subunits are commonly expressed in
            malignant effusions from ovarian carcinoma patients
  JOURNAL   Gynecol. Oncol. 90 (2), 248-257 (2003)
  MEDLINE   22775176
   PUBMED   12893184
  REMARK    GeneRIF: AlphaV- and beta1-integrin subunits are commonly expressed
            in malignant effusions from ovarian carcinoma patients.
REFERENCE   61 (bases 1 to 3700)
  AUTHORS   Zhang,H., Ozaki,I., Mizuta,T., Yoshimura,T., Matsuhashi,S.,
            Hisatomi,A., Tadano,J., Sakai,T. and Yamamoto,K.
  TITLE     Mechanism of beta 1-integrin-mediated hepatoma cell growth involves
            p27 and S-phase kinase-associated protein 2
  JOURNAL   Hepatology 38 (2), 305-313 (2003)
  MEDLINE   22765377
   PUBMED   12883474
  REMARK    GeneRIF: cells overexpressing beta 1-integrin exhibited increased
            proliferation in response to hepatocyte growth factor.
REFERENCE   62 (bases 1 to 3700)
  AUTHORS   Hotchkiss,K.A., Ashton,A.W. and Schwartz,E.L.
  TITLE     Thymidine phosphorylase and 2-deoxyribose stimulate human
            endothelial cell migration by specific activation of the integrins
            alpha 5 beta 1 and alpha V beta 3
  JOURNAL   J. Biol. Chem. 278 (21), 19272-19279 (2003)
  MEDLINE   22638366
   PUBMED   12639965
  REMARK    GeneRIF: thymidine phosphorylase and 2-deoxyribose-induced focal
            adhesion kinase phosphorylation was blocked by the antibodies to
            integrins alpha 5 beta 1 and alpha v beta 3, directly linking their
            migration and signaling components
REFERENCE   63 (bases 1 to 3700)
  AUTHORS   Pankov,R., Cukierman,E., Clark,K., Matsumoto,K., Hahn,C., Poulin,B.
            and Yamada,K.M.
  TITLE     Specific beta1 integrin site selectively regulates Akt/protein
            kinase B signaling via local activation of protein phosphatase 2A
  JOURNAL   J. Biol. Chem. 278 (20), 18671-18681 (2003)
  MEDLINE   22625681
   PUBMED   12637511
  REMARK    GeneRIF: beta1 integrin has a role in selectively regulates
            Akt/protein kinase B signaling via local activation of protein
            phosphatase 2A
REFERENCE   64 (bases 1 to 3700)
  AUTHORS   Loducca,S.V., Mantesso,A., Kapas,S., Williams,D.M., Ara and Ara.
  TITLE     Salivary gland tumours: immunoexpression of integrins beta 1, beta
            3 and beta 4
  JOURNAL   J. Oral Pathol. Med. 32 (5), 305-309 (2003)
  MEDLINE   22581883
   PUBMED   12694355
  REMARK    GeneRIF: This study revealed detailed topography of integrins in
            malignant tumours derived from intercalated acinar segment of
            salivary gland which might be useful their diagnosis , especially
            of fine-needle aspiration products or from incisional biopsy.
REFERENCE   65 (bases 1 to 3700)
  AUTHORS   Sudhakar,A., Sugimoto,H., Yang,C., Lively,J., Zeisberg,M. and
            Kalluri,R.
  TITLE     Human tumstatin and human endostatin exhibit distinct
            antiangiogenic activities mediated by alpha v beta 3 and alpha 5
            beta 1 integrins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (8), 4766-4771 (2003)
  MEDLINE   22584424
   PUBMED   12682293
  REMARK    GeneRIF: endostatin competes with fibronectin/RGD cyclic peptide to
            bind alpha 5 beta 1 integrin
REFERENCE   66 (bases 1 to 3700)
  AUTHORS   Honor, Kovacic,H., Pichard,V., Briand,C. and Rognoni,J.B.
  TITLE     Alpha2beta1-integrin signaling by itself controls G1/S transition
            in a human adenocarcinoma cell line (Caco-2): implication of NADPH
            oxidase-dependent production of ROS
  JOURNAL   Exp. Cell Res. 285 (1), 59-71 (2003)
  MEDLINE   22568361
   PUBMED   12681287
  REMARK    GeneRIF: Data show that NADPH oxidase activation production of
            reactive oxygen species are involved in the increase of
            alpha2beta1-integrin plasma membrane expression in Caco-2 cells
            stimulated with type IV collagen.
REFERENCE   67 (bases 1 to 3700)
  AUTHORS   Karpusas,M., Ferrant,J., Weinreb,P.H., Carmillo,A., Taylor,F.R. and
            Garber,E.A.
  TITLE     Crystal structure of the alpha1beta1 integrin I domain in complex
            with an antibody Fab fragment
  JOURNAL   J. Mol. Biol. 327 (5), 1031-1041 (2003)
  MEDLINE   22549843
   PUBMED   12662928
  REMARK    GeneRIF: determination of crystal structure in complex with an
            antibody Fab fragment
REFERENCE   68 (bases 1 to 3700)
  AUTHORS   Hanashi,H., Shiokawa,S., Akimoto,Y., Sakai,K., Sakai,K., Suzuki,N.,
            Kabir-Salmani,M., Nagamatsu,S., Iwashita,M. and Nakamura,Y.
  TITLE     Physiologic role of decidual beta1 integrin and focal adhesion
            kinase in embryonic implantation
  JOURNAL   Endocr. J. 50 (2), 189-198 (2003)
  MEDLINE   22687459
   PUBMED   12803239
  REMARK    GeneRIF: Decidual beta1 integrin and FAK participate in this final
            step of implantation.
REFERENCE   69 (bases 1 to 3700)
  AUTHORS   Thodeti,C.K., Albrechtsen,R., Grauslund,M., Asmar,M., Larsson,C.,
            Takada,Y., Mercurio,A.M., Couchman,J.R. and Wewer,U.M.
  TITLE     ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell
            spreading through protein kinase Calpha and RhoA
  JOURNAL   J. Biol. Chem. 278 (11), 9576-9584 (2003)
  MEDLINE   22513891
   PUBMED   12509413
  REMARK    GeneRIF: beta(1) integrin has a role in the syndecan-4 pathway for
            cell spreading, along with PKCalpha and RhoA
REFERENCE   70 (bases 1 to 3700)
  AUTHORS   Weston,B.S., Wahab,N.A. and Mason,R.M.
  TITLE     CTGF mediates TGF-beta-induced fibronectin matrix deposition by
            upregulating active alpha5beta1 integrin in human mesangial cells
  JOURNAL   J. Am. Soc. Nephrol. 14 (3), 601-610 (2003)
  MEDLINE   22483796
   PUBMED   12595495
  REMARK    GeneRIF: Alterations in alpha5beta1 levels induced by TGF-beta are
            mediated at least in part through the induction of CTGF in
            glomerular mesangium
REFERENCE   71 (bases 1 to 3700)
  AUTHORS   Zhang,W.M., Kapyla,J., Puranen,J.S., Knight,C.G., Tiger,C.F.,
            Pentikainen,O.T., Johnson,M.S., Farndale,R.W., Heino,J. and
            Gullberg,D.
  TITLE     alpha 11beta 1 integrin recognizes the GFOGER sequence in
            interstitial collagens
  JOURNAL   J. Biol. Chem. 278 (9), 7270-7277 (2003)
  MEDLINE   22486682
   PUBMED   12496264
  REMARK    GeneRIF: the GFOGER sequence in fibrillar collagens is a common
            recognition motif used by integrins, particularly alpha11beta1
REFERENCE   72 (bases 1 to 3700)
  AUTHORS   Spessotto,P., Cervi,M., Mucignat,M.T., Mungiguerra,G.,
            Sartoretto,I., Doliana,R. and Colombatti,A.
  TITLE     beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by
            the gC1q domain
  JOURNAL   J. Biol. Chem. 278 (8), 6160-6167 (2003)
  MEDLINE   22476907
   PUBMED   12456677
  REMARK    GeneRIF: beta1 Integrin-dependent cell adhesion to EMILIN-1 is
            mediated by its gC1q domain
REFERENCE   73 (bases 1 to 3700)
  AUTHORS   Evans,R.D., Perkins,V.C., Henry,A., Stephens,P.E., Robinson,M.K.
            and Watt,F.M.
  TITLE     A tumor-associated beta 1 integrin mutation that abrogates
            epithelial differentiation control
  JOURNAL   J. Cell Biol. 160 (4), 589-596 (2003)
  MEDLINE   22479689
   PUBMED   12578911
  REMARK    GeneRIF: Results establish, for the first time, mutation as a
            mechanism by which integrins can contribute to neoplasia.
REFERENCE   74 (bases 1 to 3700)
  AUTHORS   Astier,A.L., Xu,R., Svoboda,M., Hinds,E., Munoz,O., de Beaumont,R.,
            Crean,C.D., Gabig,T. and Freedman,A.S.
  TITLE     Temporal gene expression profile of human precursor B leukemia
            cells induced by adhesion receptor: identification of pathways
            regulating B-cell survival
  JOURNAL   Blood 101 (3), 1118-1127 (2003)
  MEDLINE   22417156
   PUBMED   12393420
  REMARK    GeneRIF: Temporal gene expression profile of precursor B leukemia
            cells induced by ITGB1 identifies pathways regulating B-cell
            survival.
REFERENCE   75 (bases 1 to 3700)
  AUTHORS   Vacca,R.A., Marra,E., Loverro,G., Maiorano,E., Napoli,A.,
            Lovecchio,M., Selvaggi,L. and Perlino,E.
  TITLE     Differential expression of beta 1c integrin messenger ribonucleic
            acid and protein levels in human endometrium and decidua during the
            menstrual cycle and pregnancy
  JOURNAL   J. Clin. Endocrinol. Metab. 88 (2), 720-729 (2003)
  MEDLINE   22461849
   PUBMED   12574205
  REMARK    GeneRIF: that the expression of beta(1C) integrin, a very efficient
            inhibitor of cell proliferation, may be modulated by the maternal
            microenvironment and may play a fundamental role in mediating
            trophoblast outgrowth and migration during pregnancy.
REFERENCE   76 (bases 1 to 3700)
  AUTHORS   Gutierrez-Lopez,M.D., Ovalle,S., Yanez-Mo,M., Sanchez-Sanchez,N.,
            Rubinstein,E., Olmo,N., Lizarbe,M.A., Sanchez-Madrid,F. and
            Cabanas,C.
  TITLE     A functionally relevant conformational epitope on the CD9
            tetraspanin depends on the association with activated beta1
            integrin
  JOURNAL   J. Biol. Chem. 278 (1), 208-218 (2003)
  MEDLINE   22393487
   PUBMED   12411441
  REMARK    GeneRIF: Data show that the expression of the PAINS-13 epitope
            depends on CD9 association with alpha(6)beta(1) integrin.
REFERENCE   77 (bases 1 to 3700)
  AUTHORS   Arboleda,M.J., Lyons,J.F., Kabbinavar,F.F., Bray,M.R., Snow,B.E.,
            Ayala,R., Danino,M., Karlan,B.Y. and Slamon,D.J.
  TITLE     Overexpression of AKT2/protein kinase Bbeta leads to up-regulation
            of beta1 integrins, increased invasion, and metastasis of human
            breast and ovarian cancer cells
  JOURNAL   Cancer Res. 63 (1), 196-206 (2003)
  MEDLINE   22405451
   PUBMED   12517798
  REMARK    GeneRIF: Overexpression of AKT2/protein kinase Bbeta leads to
            up-regulation, increased invasion, and metastasis of human breast
            and ovarian cancer cells.
REFERENCE   78 (bases 1 to 3700)
  AUTHORS   Sawai,H., Funahashi,H., Yamamoto,M., Okada,Y., Hayakawa,T.,
            Tanaka,M., Takeyama,H. and Manabe,T.
  TITLE     Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and
            metastatic capability of human pancreatic cancer
  JOURNAL   Oncology 65 (2), 167-173 (2003)
  MEDLINE   22812158
   PUBMED   12931024
  REMARK    GeneRIF: In pancreatic cancer, IL-1alpha enhanced
            alpha(6)beta(1)-integrin expression, probably via increased IL-1RI
            levels.
REFERENCE   79 (bases 1 to 3700)
  AUTHORS   Danen,E.H., Sonneveld,P., Brakebusch,C., Fassler,R. and
            Sonnenberg,A.
  TITLE     The fibronectin-binding integrins alpha5beta1 and alphavbeta3
            differentially modulate RhoA-GTP loading, organization of cell
            matrix adhesions, and fibronectin fibrillogenesis
  JOURNAL   J. Cell Biol. 159 (6), 1071-1086 (2002)
  MEDLINE   22387636
   PUBMED   12486108
  REMARK    GeneRIF: integrin alpha5beta1-mediated control of the levels of
            integrin alphaVbeta3 is important for the distribution of focal
            contacts
REFERENCE   80 (bases 1 to 3700)
  AUTHORS   Leu,S.J., Lam,S.C. and Lau,L.F.
  TITLE     Pro-angiogenic activities of CYR61 (CCN1) mediated through
            integrins alphavbeta3 and alpha6beta1 in human umbilical vein
            endothelial cells
  JOURNAL   J. Biol. Chem. 277 (48), 46248-46255 (2002)
  MEDLINE   22336473
   PUBMED   12364323
  REMARK    GeneRIF: role in mediating pro-angiogenic activity of CYR61
REFERENCE   81 (bases 1 to 3700)
  AUTHORS   G, Mat, Y, S and Arroyo,A.G.
  TITLE     ECM regulates MT1-MMP localization with beta1 or alphavbeta3
            integrins at distinct cell compartments modulating its
            internalization and activity on human endothelial cells
  JOURNAL   J. Cell Biol. 159 (3), 509-521 (2002)
  MEDLINE   22315156
   PUBMED   12427871
  REMARK    GeneRIF: Data show a novel mechanism by which ECM regulates
            membrane-type 1 matrix metalloproteinase (MT1-MMP) association with
            beta1 or alphavbeta3 integrins, thus modulating its
            internalization, activity, and function on human endothelial cells.
REFERENCE   82 (bases 1 to 3700)
  AUTHORS   Barazi,H.O., Li,Z., Cashel,J.A., Krutzsch,H.C., Annis,D.S.,
            Mosher,D.F. and Roberts,D.D.
  TITLE     Regulation of integrin function by CD47 ligands. Differential
            effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated
            adhesion
  JOURNAL   J. Biol. Chem. 277 (45), 42859-42866 (2002)
  MEDLINE   22302014
   PUBMED   12218055
  REMARK    GeneRIF: regulation of alpha4beta1 integrin function in melanoma
            cells and T cells by ligands of CD47
REFERENCE   83 (bases 1 to 3700)
  AUTHORS   El Ghalbzouri,A., Lamme,E. and Ponec,M.
  TITLE     Crucial role of fibroblasts in regulating epidermal morphogenesis
  JOURNAL   Cell Tissue Res. 310 (2), 189-199 (2002)
  MEDLINE   22283586
   PUBMED   12397374
REFERENCE   84 (bases 1 to 3700)
  AUTHORS   Liu,L., Schwartz,B.R., Tupper,J., Lin,N., Winn,R.K. and Harlan,J.M.
  TITLE     The GTPase Rap1 regulates phorbol 12-myristate
            13-acetate-stimulated but not ligand-induced beta 1
            integrin-dependent leukocyte adhesion
  JOURNAL   J. Biol. Chem. 277 (43), 40893-40900 (2002)
  MEDLINE   22287313
   PUBMED   12091396
  REMARK    GeneRIF: role in regulating beta 1 integrin-dependent leukocyte
            adhesion
REFERENCE   85 (bases 1 to 3700)
  AUTHORS   Shamri,R., Grabovsky,V., Feigelson,S.W., Dwir,O., Van Kooyk,Y. and
            Alon,R.
  TITLE     Chemokine stimulation of lymphocyte alpha 4 integrin avidity but
            not of leukocyte function-associated antigen-1 avidity to
            endothelial ligands under shear flow requires cholesterol membrane
            rafts
  JOURNAL   J. Biol. Chem. 277 (42), 40027-40035 (2002)
  MEDLINE   22267251
   PUBMED   12163503
  REMARK    GeneRIF: VLA4 integrin activation by chemokines requires
            cholesterol
REFERENCE   86 (bases 1 to 3700)
  AUTHORS   Festuccia,C., Angelucci,A., Gravina,G., Eleuterio,E., Vicentini,C.
            and Bologna,M.
  TITLE     Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells
            requires beta1 integrin engagement
  JOURNAL   Exp. Cell Res. 280 (1), 1-11 (2002)
  MEDLINE   22259967
   PUBMED   12372334
  REMARK    GeneRIF: beta1 integrin engagement is required for
            bombesin-dependent pro-MMP-9 activation in prostatic cancer cells
            GeneRIF: beta1 integrin engagement is required for
            bombesin-dependent pro-MMP-9 activation in prostatic cancer cells
REFERENCE   87 (bases 1 to 3700)
  AUTHORS   Laplantine,E., Maurer,P., Vallar,L., Eble,J., Paulsson,M.,
            Bruckner,P., Kieffer,N. and Aumailley,M.
  TITLE     The integrin beta1 subunit cytoplasmic tail forms oligomers: a
            potential role in beta1 integrin clustering
  JOURNAL   Biol. Cell 94 (6), 375-387 (2002)
  MEDLINE   22388720
   PUBMED   12500944
  REMARK    GeneRIF: integrin beta1 cytoplasmic peptides self-associate; role
            in beta1 integrin clustering and formation of focal adhesions
REFERENCE   88 (bases 1 to 3700)
  AUTHORS   Whittard,J.D., Craig,S.E., Mould,A.P., Koch,A., Pertz,O., Engel,J.
            and Humphries,M.J.
  TITLE     E-cadherin is a ligand for integrin alpha2beta1
  JOURNAL   Matrix Biol. 21 (6), 525-532 (2002)
  MEDLINE   22281965
   PUBMED   12392763
  REMARK    GeneRIF: findings demonstrate that E-cadherin can interact with
            alpha2beta1 and suggest that heterotypic interactions between
            E-cadherin and integrins may be more common than originally thought
REFERENCE   89 (bases 1 to 3700)
  AUTHORS   Artym,V.V., Kindzelskii,A.L., Chen,W.T. and Petty,H.R.
  TITLE     Molecular proximity of seprase and the urokinase-type plasminogen
            activator receptor on malignant melanoma cell membranes: dependence
            on beta1 integrins and the cytoskeleton
  JOURNAL   Carcinogenesis 23 (10), 1593-1601 (2002)
  MEDLINE   22263359
   PUBMED   12376466
  REMARK    GeneRIF: molecular proximity of seprase and the urokinase-type
            plasminogen activator receptor on malignant melanoma cell
            membranes: dependence on the cytoskeleton and this protein
REFERENCE   90 (bases 1 to 3700)
  AUTHORS   Witz,C.A., Cho,S., Montoya-Rodriguez,I.A. and Schenken,R.S.
  TITLE     The alpha(2)beta(1) and alpha(3)beta(1) integrins do not mediate
            attachment of endometrial cells to peritoneal mesothelium
  JOURNAL   Fertil. Steril. 78 (4), 796-803 (2002)
  MEDLINE   22260049
   PUBMED   12372459
  REMARK    GeneRIF: initial adhesion of endometrial cells to mesothelium is
            not mediated by beta1 integrins but attachment to collagen IV and
            collagen I, which are present in the submesothelial extracellular
            matrix, is mediated by beta1 integrins
REFERENCE   91 (bases 1 to 3700)
  AUTHORS   Blaschke,F., Stawowy,P., Goetze,S., Hintz,O., Gr, Kintscher,U.,
            Fleck,E. and Graf,K.
  TITLE     Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase
            in human vascular smooth muscle cells
  JOURNAL   Biochem. Biophys. Res. Commun. 296 (4), 890-896 (2002)
  MEDLINE   22188355
   PUBMED   12200131
  REMARK    GeneRIF: ITGB1 activated by ERK1/2, p38 MAPK after hypoxia
REFERENCE   92 (bases 1 to 3700)
  AUTHORS   Zhang,H., Ozaki,I., Mizuta,T., Matsuhashi,S., Yoshimura,T.,
            Hisatomi,A., Tadano,J., Sakai,T. and Yamamoto,K.
  TITLE     Beta 1-integrin protects hepatoma cells from chemotherapy induced
            apoptosis via a mitogen-activated protein kinase dependent pathway
  JOURNAL   Cancer 95 (4), 896-906 (2002)
  MEDLINE   22197470
   PUBMED   12209735
  REMARK    GeneRIF: data suggest that overexpression of beta 1-integrin
            confers resistance to apoptosis in hepatoma cells via a MAP kinase
            dependent pathway
REFERENCE   93 (bases 1 to 3700)
  AUTHORS   Valencik,M.L., Keller,R.S., Loftus,J.C. and McDonald,J.A.
  TITLE     A lethal perinatal cardiac phenotype resulting from altered
            integrin function in cardiomyocytes
  JOURNAL   J. Card. Fail. 8 (4), 262-272 (2002)
  MEDLINE   22284081
   PUBMED   12397575
  REMARK    GeneRIF: results are consistent with an essential role for beta(1)
            integrins in maintenance of cardiomyocyte viability and interaction
            with extracellular matrix
REFERENCE   94 (bases 1 to 3700)
  AUTHORS   Lindberg,L.E., Hedjazifar,S. and Baeckstr.
  TITLE     c-erbB2-induced disruption of matrix adhesion and morphogenesis
            reveals a novel role for protein kinase B as a negative regulator
            of alpha(2)beta(1) integrin function
  JOURNAL   Mol. Biol. Cell 13 (8), 2894-2908 (2002)
  MEDLINE   22169212
   PUBMED   12181354
  REMARK    GeneRIF: Data report the identification of signaling pathways
            required for suppression of integrin alpha2beta1 function by
            c-erbB2.
REFERENCE   95 (bases 1 to 3700)
  AUTHORS   Rintoul,R.C., Buttery,R.C., Mackinnon,A.C., Wong,W.S., Mosher,D.,
            Haslett,C. and Sethi,T.
  TITLE     Cross-linking CD98 promotes integrin-like signaling and
            anchorage-independent growth
  JOURNAL   Mol. Biol. Cell 13 (8), 2841-2852 (2002)
  MEDLINE   22169208
   PUBMED   12181350
  REMARK    GeneRIF: Data show that, in vitro, under physiological conditions,
            CD98 is constitutively associated with beta1 integrins regardless
            of activation status.
REFERENCE   96 (bases 1 to 3700)
  AUTHORS   Su,J.M., Gui,L., Zhou,Y.P. and Zha,X.L.
  TITLE     Expression of focal adhesion kinase and alpha5 and beta1 integrins
            in carcinomas and its clinical significance
  JOURNAL   World J. Gastroenterol. 8 (4), 613-618 (2002)
  MEDLINE   22164352
   PUBMED   12174366
  REMARK    GeneRIF: Expression of focal adhesion kinase and alpha5 and beta1
            integrins in carcinomas and its clinical significance.
REFERENCE   97 (bases 1 to 3700)
  AUTHORS   Klein,S., de Fougerolles,A.R., Blaikie,P., Khan,L., Pepe,A.,
            Green,C.D., Koteliansky,V. and Giancotti,F.G.
  TITLE     Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program
            of gene expression important for angiogenesis and inflammation
  JOURNAL   Mol. Cell. Biol. 22 (16), 5912-5922 (2002)
  MEDLINE   22133604
   PUBMED   12138201
  REMARK    GeneRIF: results suggest that engagement of the alpha 5 beta 1
            integrin promotes an NF-kappa B-dependent program of gene
            expression that coordinately regulates angiogenesis and
            inflammation
REFERENCE   98 (bases 1 to 3700)
  AUTHORS   Oh,J.E., Park,K.H., Noh,H.K., Kim,J.M., Chung,C.P. and Min,B.M.
  TITLE     Decreased expression of alpha3 and beta1 integrin subunits is
            responsible for differentiation-associated changes in cells
            behavior in terminally differentiated human oral keratinocytes
  JOURNAL   Cell Commun. Adhes. 9 (4), 173-187 (2002)
  MEDLINE   22584829
   PUBMED   12699087
  REMARK    GeneRIF: expression of beta1 integrin subunit is responsible for
            differentiation-associated changes in cells behavior in terminally
            differentiated oral keratinocytes
REFERENCE   99 (bases 1 to 3700)
  AUTHORS   Mould,A.P., Askari,J.A., Barton,S., Kline,A.D., McEwan,P.A.,
            Craig,S.E. and Humphries,M.J.
  TITLE     Integrin activation involves a conformational change in the alpha 1
            helix of the beta subunit A-domain
  JOURNAL   J. Biol. Chem. 277 (22), 19800-19805 (2002)
  MEDLINE   22028044
   PUBMED   11893752
  REMARK    GeneRIF: Integrin activation involves a conformational change in
            the alpha 1 helix of the beta subunit A-domain
REFERENCE   100 (bases 1 to 3700)
  AUTHORS   Cordes,N., Blaese,M.A., Meineke,V. and Van Beuningen,D.
  TITLE     Ionizing radiation induces up-regulation of functional
            beta1-integrin in human lung tumour cell lines in vitro
  JOURNAL   Int. J. Radiat. Biol. 78 (5), 347-357 (2002)
  MEDLINE   22015738
   PUBMED   12020426
  REMARK    GeneRIF: Ionizing radiation strongly induced the expression of
            functional beta1-integrin and ILK in the two lung cancer cell
            lines, A549 and SKMES1.
REFERENCE   101 (bases 1 to 3700)
  AUTHORS   Iwata,S., Kobayashi,H., Miyake-Nishijima,R., Sasaki,T.,
            Souta-Kuribara,A., Nori,M., Hosono,O., Kawasaki,H., Tanaka,H. and
            Morimoto,C.
  TITLE     Distinctive signaling pathways through CD82 and beta1 integrins in
            human T cells
  JOURNAL   Eur. J. Immunol. 32 (5), 1328-1337 (2002)
  MEDLINE   22021181
   PUBMED   11981820
  REMARK    GeneRIF: Evidence for distinctive signaling of CD82- and beta1
            integrin-mediated costimulation at the transcriptional level of
            IL-2 gene.
REFERENCE   102 (bases 1 to 3700)
  AUTHORS   Rubio,G., Ferez,X., Mora,A., Galvez,J., Chicano,A. and Garcia-Pe.
  TITLE     Beta1 integrin triggering affects leukemic cell line sensitivity to
            natural killer cells
  JOURNAL   Cancer Immunol. Immunother. 51 (3), 130-138 (2002)
  MEDLINE   21937788
   PUBMED   11941451
  REMARK    GeneRIF: Beta1 integrin triggering affects leukemic cell line
            sensitivity to natural killer cells
REFERENCE   103 (bases 1 to 3700)
  AUTHORS   Reyes-Reyes,M., Mora,N., Gonzalez,G. and Rosales,C.
  TITLE     beta1 and beta2 integrins activate different signalling pathways in
            monocytes
  JOURNAL   Biochem. J. 363 (Pt 2), 273-280 (2002)
  MEDLINE   21929364
   PUBMED   11931654
  REMARK    GeneRIF: beta1 and beta2 integrins activate different signalling
            pathways in monocytes.
REFERENCE   104 (bases 1 to 3700)
  AUTHORS   Wu,Y., Chen,L., Zheng,P.S. and Yang,B.B.
  TITLE     beta 1-Integrin-mediated glioma cell adhesion and free
            radical-induced apoptosis are regulated by binding to a C-terminal
            domain of PG-M/versican
  JOURNAL   J. Biol. Chem. 277 (14), 12294-12301 (2002)
  MEDLINE   21922822
   PUBMED   11805102
  REMARK    GeneRIF: beta 1-Integrin-mediated glioma cell adhesion and free
            radical-induced apoptosis are regulated by binding to a C-terminal
            domain of PG-M/versican
REFERENCE   105 (bases 1 to 3700)
  AUTHORS   Takagi,J., DeBottis,D.P., Erickson,H.P. and Springer,T.A.
  TITLE     The role of the specificity-determining loop of the integrin beta
            subunit I-like domain in autonomous expression, association with
            the alpha subunit, and ligand binding
  JOURNAL   Biochemistry 41 (13), 4339-4347 (2002)
  MEDLINE   21911671
   PUBMED   11914080
  REMARK    GeneRIF: role of the specificity-determining loop of the integrin
            beta subunit I-like domain in autonomous expression, association
            with the alpha subunit, and ligand binding
REFERENCE   106 (bases 1 to 3700)
  AUTHORS   Xythalis,D., Frewin,M.B. and Gudewicz,P.W.
  TITLE     Inhibition of IL-8-mediated MAPK activation in human neutrophils by
            beta1 integrin ligands
  JOURNAL   Inflammation 26 (2), 83-88 (2002)
  MEDLINE   21985158
   PUBMED   11989791
  REMARK    GeneRIF: There is a desensitization of IL-8-mediated p42/p44 MAPK
            signaling in response to ligation of the alpha5beta1 integrin in
            PMNL. There may be an interplay between integrin and chemokine
            signaling during PMNL migration through the extracellular matrix.
REFERENCE   107 (bases 1 to 3700)
  AUTHORS   Arencibia,I., Frankel,G. and Sundqvist,K.G.
  TITLE     Induction of cell death in T lymphocytes by invasin via
            beta1-integrin
  JOURNAL   Eur. J. Immunol. 32 (4), 1129-1138 (2002)
  MEDLINE   21929698
   PUBMED   11932920
  REMARK    GeneRIF: Inv-induced cell death was mediated via beta1-integrins
            since Inv bound to the beta1-integrin subunit (CD29),
            anti-beta(1)-integrin antibodies blocked Inv-induced cell death and
            Inv-induced cell death was absent in two beta1-integrin- cell
            lines.
REFERENCE   108 (bases 1 to 3700)
  AUTHORS   Pommerenke,H., Schmidt,C., D, Nebe,B., L, Muller,P. and Rychly,J.
  TITLE     The mode of mechanical integrin stressing controls intracellular
            signaling in osteoblasts
  JOURNAL   J. Bone Miner. Res. 17 (4), 603-611 (2002)
  MEDLINE   21915144
   PUBMED   11918217
  REMARK    GeneRIF: mechanical stress to the beta1-integrin subunit in
            osteoblasts revealed that cyclic forces of 1 Hz were more effective
            to stimulate the cellular calcium response than continuous load
REFERENCE   109 (bases 1 to 3700)
  AUTHORS   Leong,K.G., Hu,X., Li,L., Noseda,M., Larriv, Hull,C., Hood,L.,
            Wong,F. and Karsan,A.
  TITLE     Activated Notch4 inhibits angiogenesis: role of beta 1-integrin
            activation
  JOURNAL   Mol. Cell. Biol. 22 (8), 2830-2841 (2002)
  MEDLINE   21907244
   PUBMED   11909975
  REMARK    GeneRIF: Activated Notch4 inhibits angiogenesis: role of beta
            1-integrin activation.
REFERENCE   110 (bases 1 to 3700)
  AUTHORS   Podar,K., Tai,Y.T., Lin,B.K., Narsimhan,R.P., Sattler,M.,
            Kijima,T., Salgia,R., Gupta,D., Chauhan,D. and Anderson,K.C.
  TITLE     Vascular endothelial growth factor-induced migration of multiple
            myeloma cells is associated with beta 1 integrin- and
            phosphatidylinositol 3-kinase-dependent PKC alpha activation
  JOURNAL   J. Biol. Chem. 277 (10), 7875-7881 (2002)
  MEDLINE   21864198
   PUBMED   11751905
  REMARK    GeneRIF: both VEGF-induced PI 3-kinase activation and beta(1)
            integrin-mediated binding to fibronectin are required for the
            recruitment and activation of PKC alpha.
REFERENCE   111 (bases 1 to 3700)
  AUTHORS   Chang,D.D., Hoang,B.Q., Liu,J. and Springer,T.A.
  TITLE     Molecular basis for interaction between Icap1 alpha PTB domain and
            beta 1 integrin
  JOURNAL   J. Biol. Chem. 277 (10), 8140-8145 (2002)
  MEDLINE   21864153
   PUBMED   11741908
  REMARK    GeneRIF: Site-directed mutagenesis showed that Leu(135), Ile(138),
            and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required
            for the Icap1 alpha-beta(1) integrin interaction
REFERENCE   112 (bases 1 to 3700)
  AUTHORS   Yang,X., Claas,C., Kraeft,S.K., Chen,L.B., Wang,Z., Kreidberg,J.A.
            and Hemler,M.E.
  TITLE     Palmitoylation of tetraspanin proteins: modulation of CD151 lateral
            interactions, subcellular distribution, and integrin-dependent cell
            morphology
  JOURNAL   Mol. Biol. Cell 13 (3), 767-781 (2002)
  MEDLINE   21904786
   PUBMED   11907260
  REMARK    GeneRIF: Data demonstrate that multiple tetraspanin (transmembrane
            4 superfamily) proteins such as CD151 are palmitoylated, and that
            palmitoylation is not required for cd151-alpha3beta1 integrin
            association.
REFERENCE   113 (bases 1 to 3700)
  AUTHORS   Schreider,C., Peignon,G., Thenet,S., Chambaz,J. and Pin.
  TITLE     Integrin-mediated functional polarization of Caco-2 cells through
            E-cadherin--actin complexes
  JOURNAL   J. Cell. Sci. 115 (Pt 3), 543-552 (2002)
  MEDLINE   21850847
   PUBMED   11861761
  REMARK    GeneRIF: These results demonstrate that integrin-dependent cell to
            extracellular matrix adhesion reinforces E-cadherin-dependent
            cell-cell adhesion in Caco-2 cells.
REFERENCE   114 (bases 1 to 3700)
  AUTHORS   Armulik,A.
  TITLE     Splice variants of human beta 1 integrins: origin, biosynthesis and
            functions
  JOURNAL   (er) Front. Biosci. 7, D219-D227 (2002)
  MEDLINE   21638231
   PUBMED   11779688
  REMARK    GeneRIF: Although cytoplasmic splice variants do not change the
            ligand-specificity of a beta 1 integrin, this review explains how
            clustering of different splice variants triggers signaling pathways
            that lead to a different cellular response.
REFERENCE   115 (bases 1 to 3700)
  AUTHORS   Sch, Potter,B.V., Mayr,G.W. and Guse,A.H.
  TITLE     Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+)
            signalling
  JOURNAL   Cell. Signal. 13 (12), 895-899 (2001)
  MEDLINE   21585352
   PUBMED   11728829
  REMARK    GeneRIF: Mechanisms involved in alpha6beta1-integrin-mediated
            Ca(2+) signalling
REFERENCE   116 (bases 1 to 3700)
  AUTHORS   Skrzypczak,J., Miko and Szymanowski,K.
  TITLE     Endometrial receptivity: expression of alpha3beta1, alpha4beta1 and
            alphaVbeta1 endometrial integrins in women with impaired fertility
  JOURNAL   J. Biol. Chem. 1 (2), 85-94 (2001)
   PUBMED   14666169
  REMARK    GeneRIF: alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may
            play an important role in the implantation process
REFERENCE   117 (bases 1 to 3700)
  AUTHORS   Meleady,P. and Clynes,M.
  TITLE     Bromodeoxyuridine induces integrin expression at transcriptional
            (alpha2 subunit) and post-transcriptional (beta1 subunit) levels,
            and alters the adhesive properties of two human lung tumour cell
            lines
  JOURNAL   Cell Commun. Adhes. 8 (1), 45-59 (2001)
  MEDLINE   21630766
   PUBMED   11775028
  REMARK    GeneRIF: Bromodeoxyuridine induces integrin expression at
            transcriptional (alpha2 subunit) and post-transcriptional (beta1
            subunit) levels, and alters the adhesive properties of two human
            lung tumour cell lines.
REFERENCE   118 (bases 1 to 3700)
  AUTHORS   Takahashi,K.
  TITLE     The linkage between beta1 integrin and the actin cytoskeleton is
            differentially regulated by tyrosine and serine/threonine
            phosphorylation of beta1 integrin in normal and cancerous human
            breast cells
  JOURNAL   BMC Cell Biol. 2 (1), 23 (2001)
  MEDLINE   22228963
   PUBMED   11716783
  REMARK    GeneRIF: the linkage between beta1 integrin and actin may be
            differentially regulated by its tyrosine and serine/threonine
            phosphorylation in normal and cancerous breast cells.
REFERENCE   119 (bases 1 to 3700)
  AUTHORS   Laidler,P., Gil,D., Pituch-Noworolska,A., Cio, Ksiazek,D., Przyby
            and Lity.
  TITLE     Expression of beta1-integrins and N-cadherin in bladder cancer and
            melanoma cell lines
  JOURNAL   Acta Biochim. Pol. 47 (4), 1159-1170 (2000)
  MEDLINE   21991130
   PUBMED   11996105
  REMARK    GeneRIF: Expression of beta1-integrins and N-cadherin in bladder
            cancer and melanoma cell lines
REFERENCE   120 (bases 1 to 3700)
  AUTHORS   Barillari,G., Sgadari,C., Fiorelli,V., Samaniego,F., Colombini,S.,
            Manzari,V., Modesti,A., Nair,B.C., Cafaro,A., St and Ensoli,B.
  TITLE     The Tat protein of human immunodeficiency virus type-1 promotes
            vascular cell growth and locomotion by engaging the alpha5beta1 and
            alphavbeta3 integrins and by mobilizing sequestered basic
            fibroblast growth factor
  JOURNAL   Blood 94 (2), 663-672 (1999)
  MEDLINE   99326318
   PUBMED   10397733
REFERENCE   121 (bases 1 to 3700)
  AUTHORS   Fiorelli,V., Barillari,G., Toschi,E., Sgadari,C., Monini,P., St and
            Ensoli,B.
  TITLE     IFN-gamma induces endothelial cells to proliferate and to invade
            the extracellular matrix in response to the HIV-1 Tat protein:
            implications for AIDS-Kaposi's sarcoma pathogenesis
  JOURNAL   J. Immunol. 162 (2), 1165-1170 (1999)
  MEDLINE   99113786
   PUBMED   9916748
REFERENCE   122 (bases 1 to 3700)
  AUTHORS   Svineng,G., F and Johansson,S.
  TITLE     Identification of beta1C-2, a novel variant of the integrin beta1
            subunit generated by utilization of an alternative splice acceptor
            site in exon C
  JOURNAL   Biochem. J. 330 (Pt 3), 1255-1263 (1998)
  MEDLINE   98161805
   PUBMED   9494094
REFERENCE   123 (bases 1 to 3700)
  AUTHORS   Benelli,R., Mortarini,R., Anichini,A., Giunciuglio,D., Noonan,D.M.,
            Montalti,S., Tacchetti,C. and Albini,A.
  TITLE     Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat
            RGD and basic peptides
  JOURNAL   AIDS 12 (3), 261-268 (1998)
  MEDLINE   98140754
   PUBMED   9517988
REFERENCE   124 (bases 1 to 3700)
  AUTHORS   Shang,X.Z., Lang,B.J. and Issekutz,A.C.
  TITLE     Adhesion molecule mechanisms mediating monocyte migration through
            synovial fibroblast and endothelium barriers: role for CD11/CD18,
            very late antigen-4 (CD49d/CD29), very late antigen-5 (CD49e/CD29),
            and vascular cell adhesion molecule-1 (CD106)
  JOURNAL   J. Immunol. 160 (1), 467-474 (1998)
  MEDLINE   98211731
   PUBMED   9552005
REFERENCE   125 (bases 1 to 3700)
  AUTHORS   Chang,D.D., Wong,C., Smith,H. and Liu,J.
  TITLE     ICAP-1, a novel beta1 integrin cytoplasmic domain-associated
            protein, binds to a conserved and functionally important NPXY
            sequence motif of beta1 integrin
  JOURNAL   J. Cell Biol. 138 (5), 1149-1157 (1997)
  MEDLINE   97428321
   PUBMED   9281591
REFERENCE   126 (bases 1 to 3700)
  AUTHORS   Zauli,G., Gibellini,D., Celeghini,C., Mischiati,C., Bassini,A., La
            Placa,M. and Capitani,S.
  TITLE     Pleiotropic effects of immobilized versus soluble recombinant HIV-1
            Tat protein on CD3-mediated activation, induction of apoptosis, and
            HIV-1 long terminal repeat transactivation in purified CD4+ T
            lymphocytes
  JOURNAL   J. Immunol. 157 (5), 2216-2224 (1996)
  MEDLINE   96355032
   PUBMED   8757349
REFERENCE   127 (bases 1 to 3700)
  AUTHORS   Lafrenie,R.M., Wahl,L.M., Epstein,J.S., Hewlett,I.K., Yamada,K.M.
            and Dhawan,S.
  TITLE     HIV-1-Tat protein promotes chemotaxis and invasive behavior by
            monocytes
  JOURNAL   J. Immunol. 157 (3), 974-977 (1996)
  MEDLINE   96338159
   PUBMED   8757599
REFERENCE   128 (bases 1 to 3700)
  AUTHORS   Zhidkova,N.I., Belkin,A.M. and Mayne,R.
  TITLE     Novel isoform of beta 1 integrin expressed in skeletal and cardiac
            muscle
  JOURNAL   Biochem. Biophys. Res. Commun. 214 (1), 279-285 (1995)
  MEDLINE   95398646
   PUBMED   7545396
REFERENCE   129 (bases 1 to 3700)
  AUTHORS   van der Flier,A., Kuikman,I., Baudoin,C., van der Neut,R. and
            Sonnenberg,A.
  TITLE     A novel beta 1 integrin isoform produced by alternative splicing:
            unique expression in cardiac and skeletal muscle
  JOURNAL   FEBS Lett. 369 (2-3), 340-344 (1995)
  MEDLINE   95377431
   PUBMED   7544298
REFERENCE   130 (bases 1 to 3700)
  AUTHORS   Albini,A., Barillari,G., Benelli,R., Gallo,R.C. and Ensoli,B.
  TITLE     Angiogenic properties of human immunodeficiency virus type 1 Tat
            protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (11), 4838-4842 (1995)
  MEDLINE   95281551
   PUBMED   7539135
REFERENCE   131 (bases 1 to 3700)
  AUTHORS   Balzac,F., Retta,S.F., Albini,A., Melchiorri,A., Koteliansky,V.E.,
            Geuna,M., Silengo,L. and Tarone,G.
  TITLE     Expression of beta 1B integrin isoform in CHO cells results in a
            dominant negative effect on cell adhesion and motility
  JOURNAL   J. Cell Biol. 127 (2), 557-565 (1994)
  MEDLINE   95014744
   PUBMED   7523423
REFERENCE   132 (bases 1 to 3700)
  AUTHORS   Barillari,G., Gendelman,R., Gallo,R.C. and Ensoli,B.
  TITLE     The Tat protein of human immunodeficiency virus type 1, a growth
            factor for AIDS Kaposi sarcoma and cytokine-activated vascular
            cells, induces adhesion of the same cell types by using integrin
            receptors recognizing the RGD amino acid sequence
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (17), 7941-7945 (1993)
  MEDLINE   93376718
   PUBMED   7690138
REFERENCE   133 (bases 1 to 3700)
  AUTHORS   Balzac,F., Belkin,A.M., Koteliansky,V.E., Balabanov,Y.V.,
            Altruda,F., Silengo,L. and Tarone,G.
  TITLE     Expression and functional analysis of a cytoplasmic domain variant
            of the beta 1 integrin subunit
  JOURNAL   J. Cell Biol. 121 (1), 171-178 (1993)
  MEDLINE   93209984
   PUBMED   7681433
REFERENCE   134 (bases 1 to 3700)
  AUTHORS   Cervella,P., Silengo,L., Pastore,C. and Altruda,F.
  TITLE     Human beta 1-integrin gene expression is regulated by two promoter
            regions
  JOURNAL   J. Biol. Chem. 268 (7), 5148-5155 (1993)
  MEDLINE   93186829
   PUBMED   8444890
REFERENCE   135 (bases 1 to 3700)
  AUTHORS   Languino,L.R. and Ruoslahti,E.
  TITLE     An alternative form of the integrin beta 1 subunit with a variant
            cytoplasmic domain
  JOURNAL   J. Biol. Chem. 267 (10), 7116-7120 (1992)
  MEDLINE   92202279
   PUBMED   1551917
REFERENCE   136 (bases 1 to 3700)
  AUTHORS   Altruda,F., Cervella,P., Tarone,G., Botta,C., Balzac,F.,
            Stefanuto,G. and Silengo,L.
  TITLE     A human integrin beta 1 subunit with a unique cytoplasmic domain
            generated by alternative mRNA processing
  JOURNAL   Gene 95 (2), 261-266 (1990)
  MEDLINE   91065539
   PUBMED   2249781
REFERENCE   137 (bases 1 to 3700)
  AUTHORS   Brake,D.A., Debouck,C. and Biesecker,G.
  TITLE     Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human
            immunodeficiency virus type 1 transactivation protein, tat
  JOURNAL   J. Cell Biol. 111 (3), 1275-1281 (1990)
  MEDLINE   90361753
   PUBMED   2202737
REFERENCE   138 (bases 1 to 3700)
  AUTHORS   Goodfellow,P.J., Nevanlinna,H.A., Gorman,P., Sheer,D., Lam,G. and
            Goodfellow,P.N.
  TITLE     Assignment of the gene encoding the beta-subunit of the human
            fibronectin receptor (beta-FNR) to chromosome 10p11.2
  JOURNAL   Ann. Hum. Genet. 53 (Pt 1), 15-22 (1989)
  MEDLINE   89271644
   PUBMED   2524991
REFERENCE   139 (bases 1 to 3700)
  AUTHORS   Argraves,W.S., Suzuki,S., Arai,H., Thompson,K., Pierschbacher,M.D.
            and Ruoslahti,E.
  TITLE     Amino acid sequence of the human fibronectin receptor
  JOURNAL   J. Cell Biol. 105 (3), 1183-1190 (1987)
  MEDLINE   88007843
   PUBMED   2958481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X07979.1, BC020057.1 and
            X68969.1.
            On Mar 26, 2002 this sequence version replaced gi:4504766.
            
            Summary: Integrins are heterodimeric proteins made up of alpha and
            beta subunits. At least 18 alpha and 8 beta subunits have been
            described in mammals. Integrin family members are membrane
            receptors involved in cell adhesion and recognition in a variety of
            processes including embryogenesis, hemostasis, tissue repair,
            immune response and metatastatic diffusion of tumor cells. The
            protein encoded by this gene is a beta subunit. Six alternatively
            spliced variants have been found for this gene which encode five
            proteins with alternate carboxy termini.
            
            Transcript Variant: This variant (1A) is the most common variant
            and has an alternate 5'UTR due to the use of the alternate proximal
            promoter. Variants 1A and 1E encode the same isoform.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.2"
     gene            1..3700
                     /gene="ITGB1"
                     /note="synonyms: CD29, FNRB, MDF2, VLAB, GPIIA, MSK12"
                     /db_xref="GeneID:3688"
                     /db_xref="MIM:135630"
     misc_feature    1
                     /gene="ITGB1"
                     /note="5' most of multiple alternative transcription
                     initiation sites"
     CDS             127..2523
                     /gene="ITGB1"
                     /note="isoform 1A precursor is encoded by transcript
                     variant 1A; integrin VLA-4 beta subunit; fibronectin
                     receptor beta subunit;
                     go_component: integrin complex [goid 0008305] [evidence
                     IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: integrin complex [goid 0008305] [evidence
                     NAS] [pmid 9552005];
                     go_function: receptor activity [goid 0004872] [evidence
                     IEA];
                     go_function: protein binding [goid 0005515] [evidence IPI]
                     [pmid 9281591];
                     go_function: protein heterodimerization activity [goid
                     0046982] [evidence NAS] [pmid 9552005];
                     go_process: development [goid 0007275] [evidence IEA];
                     go_process: cell-matrix adhesion [goid 0007160] [evidence
                     IEA];
                     go_process: homophilic cell adhesion [goid 0007156]
                     [evidence TAS] [pmid 10201960];
                     go_process: cellular defense response [goid 0006968]
                     [evidence TAS] [pmid 10201960];
                     go_process: integrin-mediated signaling pathway [goid
                     0007229] [evidence IEA]"
                     /codon_start=1
                     /product="integrin beta 1 isoform 1A precursor"
                     /protein_id="NP_002202.2"
                     /db_xref="GI:19743813"
                     /db_xref="GeneID:3688"
                     /db_xref="MIM:135630"
                     /translation="MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPN
                     CGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGT
                     AEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLE
                     NVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFS
                     YKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVF
                     STDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTI
                     FAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEG
                     VTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGF
                     TEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
                     SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGL
                     ICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPK
                     FQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQP
                     VQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGI
                     VLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
                     "
     sig_peptide     127..186
                     /gene="ITGB1"
     mat_peptide     187..2520
                     /gene="ITGB1"
                     /product="integrin beta 1 isoform 1A"
     polyA_signal    3671..3676
                     /gene="ITGB1"
     polyA_site      3699
                     /gene="ITGB1"
ORIGIN      
        1 agccgccgcc acccgccgcg cccgacaccc gggaggcccc gccagcccgc gggagaggcc
       61 cagcgggagt cgcggaacag caggcccgag cccaccgcgc cgggccccgg acgccgcgcg
      121 gaaaagatga atttacaacc aattttctgg attggactga tcagttcagt ttgctgtgtg
      181 tttgctcaaa cagatgaaaa tagatgttta aaagcaaatg ccaaatcatg tggagaatgt
      241 atacaagcag ggccaaattg tgggtggtgc acaaattcaa catttttaca ggaaggaatg
      301 cctacttctg cacgatgtga tgatttagaa gccttaaaaa agaagggttg ccctccagat
      361 gacatagaaa atcccagagg ctccaaagat ataaagaaaa ataaaaatgt aaccaaccgt
      421 agcaaaggaa cagcagagaa gctcaagcca gaggatatta ctcagatcca accacagcag
      481 ttggttttgc gattaagatc aggggagcca cagacattta cattaaaatt caagagagct
      541 gaagactatc ccattgacct ctactacctt atggacctgt cttactcaat gaaagacgat
      601 ttggagaatg taaaaagtct tggaacagat ctgatgaatg aaatgaggag gattacttcg
      661 gacttcagaa ttggatttgg ctcatttgtg gaaaagactg tgatgcctta cattagcaca
      721 acaccagcta agctcaggaa cccttgcaca agtgaacaga actgcaccag cccatttagc
      781 tacaaaaatg tgctcagtct tactaataaa ggagaagtat ttaatgaact tgttggaaaa
      841 cagcgcatat ctggaaattt ggattctcca gaaggtggtt tcgatgccat catgcaagtt
      901 gcagtttgtg gatcactgat tggctggagg aatgttacac ggctgctggt gttttccaca
      961 gatgccgggt ttcactttgc tggagatggg aaacttggtg gcattgtttt accaaatgat
     1021 ggacaatgtc acctggaaaa taatatgtac acaatgagcc attattatga ttatccttct
     1081 attgctcacc ttgtccagaa actgagtgaa aataatattc agacaatttt tgcagttact
     1141 gaagaatttc agcctgttta caaggagctg aaaaacttga tccctaagtc agcagtagga
     1201 acattatctg caaattctag caatgtaatt cagttgatca ttgatgcata caattccctt
     1261 tcctcagaag tcattttgga aaacggcaaa ttgtcagaag gagtaacaat aagttacaaa
     1321 tcttactgca agaacggggt gaatggaaca ggggaaaatg gaagaaaatg ttccaatatt
     1381 tccattggag atgaggttca atttgaaatt agcataactt caaataagtg tccaaaaaag
     1441 gattctgaca gctttaaaat taggcctctg ggctttacgg aggaagtaga ggttattctt
     1501 cagtacatct gtgaatgtga atgccaaagc gaaggcatcc ctgaaagtcc caagtgtcat
     1561 gaaggaaatg ggacatttga gtgtggcgcg tgcaggtgca atgaagggcg tgttggtaga
     1621 cattgtgaat gcagcacaga tgaagttaac agtgaagaca tggatgctta ctgcaggaaa
     1681 gaaaacagtt cagaaatctg cagtaacaat ggagagtgcg tctgcggaca gtgtgtttgt
     1741 aggaagaggg ataatacaaa tgaaatttat tctggcaaat tctgcgagtg tgataatttc
     1801 aactgtgata gatccaatgg cttaatttgt ggaggaaatg gtgtttgcaa gtgtcgtgtg
     1861 tgtgagtgca accccaacta cactggcagt gcatgtgact gttctttgga tactagtact
     1921 tgtgaagcca gcaacggaca gatctgcaat ggccggggca tctgcgagtg tggtgtctgt
     1981 aagtgtacag atccgaagtt tcaagggcaa acgtgtgaga tgtgtcagac ctgccttggt
     2041 gtctgtgctg agcataaaga atgtgttcag tgcagagcct tcaataaagg agaaaagaaa
     2101 gacacatgca cacaggaatg ttcctatttt aacattacca aggtagaaag tcgggacaaa
     2161 ttaccccagc cggtccaacc tgatcctgtg tcccattgta aggagaagga tgttgacgac
     2221 tgttggttct attttacgta ttcagtgaat gggaacaacg aggtcatggt tcatgttgtg
     2281 gagaatccag agtgtcccac tggtccagac atcattccaa ttgtagctgg tgtggttgct
     2341 ggaattgttc ttattggcct tgcattactg ctgatatgga agcttttaat gataattcat
     2401 gacagaaggg agtttgctaa atttgaaaag gagaaaatga atgccaaatg ggacacgggt
     2461 gaaaatccta tttataagag tgccgtaaca actgtggtca atccgaagta tgagggaaaa
     2521 tgagtactgc ccgtgcaaat cccacaacac tgaatgcaaa gtagcaattt ccatagtcac
     2581 agttaggtag ctttagggca atattgccat ggttttactc atgtgcaggt tttgaaaatg
     2641 tacaatatgt ataattttta aaatgtttta ttattttgaa aataatgttg taattcatgc
     2701 cagggactga caaaagactt gagacaggat ggttattctt gtcagctaag gtcacattgt
     2761 gcctttttga ccttttcttc ctggactatt gaaatcaagc ttattggatt aagtgatatt
     2821 tctatagcga ttgaaagggc aatagttaaa gtaatgagca tgatgagagt ttctgttaat
     2881 catgtattaa aactgatttt tagctttaca aatatgtcag tttgcagtta tgcagaatcc
     2941 aaagtaaatg tcctgctagc tagttaagga ttgttttaaa tctgttattt tgctatttgc
     3001 ctgttagaca tgactgatga catatctgaa agacaagtat gttgagagtt gctggtgtaa
     3061 aatacgtttg aaatagttga tctacaaagg ccatgggaaa aattcagaga gttaggaagg
     3121 aaaaaccaat agctttaaaa cctgtgtgcc attttaagag ttacttaatg tttggtaact
     3181 tttatgcctt cactttacaa attcaagcct tagataaaag aaccgagcaa ttttctgcta
     3241 aaaagtcctt gatttagcac tatttacata caggccatac tttacaaagt atttgctgaa
     3301 tggggacctt ttgagttgaa tttattttat tatttttatt ttgtttaatg tctggtgctt
     3361 tctatcacct cttctaatct tttaatgtat ttgtttgcaa ttttggggta agactttttt
     3421 atgagtactt tttctttgaa gttttagcgg tcaatttgcc tttttaatga acatgtgaag
     3481 ttatactgtg gctatgcaac agctctcacc tacgcgagtc ttactttgag ttagtgccat
     3541 aacagaccac tgtatgttta cttctcacca tttgagttgc ccatcttgtt tcacactagt
     3601 cacattcttg ttttaagtgc ctttagtttt aacagttcac tttttacagt gctatttact
     3661 gaagttattt attaaatatg cctaaaatac ttaaatcgga
//

LOCUS       NM_002293               7923 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens laminin, gamma 1 (formerly LAMB2) (LAMC1), mRNA.
ACCESSION   NM_002293
VERSION     NM_002293.2  GI:9845497
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7923)
  AUTHORS   Li,J., Tzu,J., Chen,Y., Zhang,Y.P., Nguyen,N.T., Gao,J.,
            Bradley,M., Keene,D.R., Oro,A.E., Miner,J.H. and Marinkovich,M.P.
  TITLE     Laminin-10 is crucial for hair morphogenesis
  JOURNAL   EMBO J. 22 (10), 2400-2410 (2003)
   PUBMED   12743034
  REMARK    GeneRIF: Data suggest that laminin-10 (alpha5beta1gamma1) is
            required for hair follicle development and report the first use of
            exogenous protein to correct a cutaneous developmental defect.
REFERENCE   2  (bases 1 to 7923)
  AUTHORS   Inagaki,J., Sugiura-Ogasawara,M., Nomizu,M., Nakatsuka,M.,
            Ikuta,K., Suzuki,N., Kaihara,K., Kobayashi,K., Yasuda,T.,
            Shoenfeld,Y., Aoki,K. and Matsuura,E.
  TITLE     An association of IgG anti-laminin-1 autoantibodies with
            endometriosis in infertile patients
  JOURNAL   Hum. Reprod. 18 (3), 544-549 (2003)
   PUBMED   12615822
  REMARK    GeneRIF: mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains
            was expressed in 90% of endometriotic lesions.
REFERENCE   3  (bases 1 to 7923)
  AUTHORS   Wiksten,M., Liebkind,R., Laatikainen,T. and Liesi,P.
  TITLE     Gamma 1 laminin and its biologically active KDI-domain may guide
            axons in the floor plate of human embryonic spinal cord
  JOURNAL   J. Neurosci. Res. 71 (3), 338-352 (2003)
   PUBMED   12526023
  REMARK    GeneRIF: The neurite outgrowth domain of gamma 1 laminin
            accumulates heavily in the floor plate region, in the notochord and
            in GFAP-immunoreactive glial fibers of the embryonic spinal cord.
REFERENCE   4  (bases 1 to 7923)
  AUTHORS   Palu,E. and Liesi,P.
  TITLE     Differential distribution of laminins in Alzheimer disease and
            normal human brain tissue
  JOURNAL   J. Neurosci. Res. 69 (2), 243-256 (2002)
   PUBMED   12111806
  REMARK    GeneRIF: Enhanced and specialized expression patterns of alpha 1
            and gamma 1 laminins distinctly associate these two laminins with
            the Alzheimer disease.
REFERENCE   5  (bases 1 to 7923)
  AUTHORS   McArthur,C.P., Wang,Y., Heruth,D. and Gustafson,S.
  TITLE     Amplification of extracellular matrix and oncogenes in
            tat-transfected human salivary gland cell lines with expression of
            laminin, fibronectin, collagens I, III, IV, c-myc and p53
  JOURNAL   Arch. Oral Biol. 46 (6), 545-555 (2001)
   PUBMED   11311202
REFERENCE   6  (bases 1 to 7923)
  AUTHORS   Smyth,N., Vatansever,H.S., Murray,P., Meyer,M., Frie,C.,
            Paulsson,M. and Edgar,D.
  TITLE     Absence of basement membranes after targeting the LAMC1 gene
            results in embryonic lethality due to failure of endoderm
            differentiation
  JOURNAL   J. Cell Biol. 144 (1), 151-160 (1999)
   PUBMED   9885251
REFERENCE   7  (bases 1 to 7923)
  AUTHORS   Burgeson,R.E., Chiquet,M., Deutzmann,R., Ekblom,P., Engel,J.,
            Kleinman,H., Martin,G.R., Meneguzzi,G., Paulsson,M., Sanes,J. et
            al.
  TITLE     A new nomenclature for the laminins
  JOURNAL   Matrix Biol. 14 (3), 209-211 (1994)
   PUBMED   7921537
REFERENCE   8  (bases 1 to 7923)
  AUTHORS   Kallunki,T., Ikonen,J., Chow,L.T., Kallunki,P. and Tryggvason,K.
  TITLE     Structure of the human laminin B2 chain gene reveals extensive
            divergence from the laminin B1 chain gene
  JOURNAL   J. Biol. Chem. 266 (1), 221-228 (1991)
   PUBMED   1985895
REFERENCE   9  (bases 1 to 7923)
  AUTHORS   Santos,C.L., Sabbaga,J. and Brentani,R.
  TITLE     Differences in human laminin B2 sequences
  JOURNAL   DNA Seq. 1 (4), 275-277 (1991)
   PUBMED   1806043
REFERENCE   10 (bases 1 to 7923)
  AUTHORS   Hunter,D.D., Shah,V., Merlie,J.P. and Sanes,J.R.
  TITLE     A laminin-like adhesive protein concentrated in the synaptic cleft
            of the neuromuscular junction
  JOURNAL   Nature 338 (6212), 229-234 (1989)
   PUBMED   2922051
REFERENCE   11 (bases 1 to 7923)
  AUTHORS   Pikkarainen,T., Kallunki,T. and Tryggvason,K.
  TITLE     Human laminin B2 chain. Comparison of the complete amino acid
            sequence with the B1 chain reveals variability in sequence homology
            between different structural domains
  JOURNAL   J. Biol. Chem. 263 (14), 6751-6758 (1988)
   PUBMED   3360804
REFERENCE   12 (bases 1 to 7923)
  AUTHORS   Fukushima,Y., Pikkarainen,T., Kallunki,T., Eddy,R.L., Byers,M.G.,
            Haley,L.L., Henry,W.M., Tryggvason,K. and Shows,T.B.
  TITLE     Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment
            of the gene to chromosome region 1q25----q31
  JOURNAL   Cytogenet. Cell Genet. 48 (3), 137-141 (1988)
   PUBMED   3234037
REFERENCE   13 (bases 1 to 7923)
  AUTHORS   Davis,J.M., Narachi,M.A., Alton,N.K. and Arakawa,T.
  TITLE     Structure of human tumor necrosis factor alpha derived from
            recombinant DNA
  JOURNAL   Biochemistry 26 (5), 1322-1326 (1987)
   PUBMED   3552045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M55210.1.
            On Aug 18, 2000 this sequence version replaced gi:4504954.
            
            Summary:  Laminins, a family of extracellular matrix glycoproteins,
            are the major noncollagenous constituent of basement membranes.
            They have been implicated in a wide variety of biological processes
            including cell adhesion, differentiation, migration, signaling,
            neurite outgrowth and metastasis. Laminins are composed of 3 non
            identical chains: laminin alpha, beta and gamma (formerly A, B1,
            and B2, respectively) and they form a cruciform structure
            consisting of 3 short arms, each formed by a different chain, and a
            long arm composed of all 3 chains. Each laminin chain is a
            multidomain protein encoded by a distinct gene. Several isoforms of
            each chain have been described. Different alpha, beta and gamma
            chain isomers combine to give rise to different heterotrimeric
            laminin isoforms which are designated by Arabic numerals in the
            order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
            laminin 1. The biological functions of the different chains and
            trimer molecules are largely unknown, but some of the chains have
            been shown to differ with respect to their tissue distribution,
            presumably reflecting diverse functions in vivo. This gene encodes
            the gamma chain isoform laminin, gamma 1. The gamma 1 chain,
            formerly thought to be a beta chain, contains structural domains
            similar to beta chains, however, lacks the short alpha region
            separating domains I and II. The structural organization of this
            gene also suggested that it had diverged considerably from the beta
            chain genes. Embryos of transgenic mice in which both alleles of
            the gamma 1 chain gene were inactivated by homologous
            recombination, lacked basement membranes, indicating that laminin,
            gamma 1 chain is necessary for laminin heterotrimer assembly. It
            has been inferred by analogy with the strikingly similar 3' UTR
            sequence in mouse laminin gamma 1 cDNA, that multiple
            polyadenylation sites are utilized in human to generate the 2
            different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31"
     gene            1..7923
                     /gene="LAMC1"
                     /note="synonym: LAMB2"
                     /db_xref="GeneID:3915"
                     /db_xref="MIM:150290"
     CDS             300..5129
                     /gene="LAMC1"
                     /note="formerly LAMB2;
                     go_component: basement membrane [goid 0005604] [evidence
                     TAS] [pmid 9885251];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: structural molecule activity [goid 0005198]
                     [evidence IEA];
                     go_process: cell adhesion [goid 0007155] [evidence IEA];
                     go_process: endoderm development [goid 0007492] [evidence
                     TAS] [pmid 9885251];
                     go_process: protein complex assembly [goid 0006461]
                     [evidence TAS] [pmid 9885251]"
                     /codon_start=1
                     /product="laminin, gamma 1 precursor"
                     /protein_id="NP_002284.2"
                     /db_xref="GI:9845498"
                     /db_xref="GeneID:3915"
                     /db_xref="MIM:150290"
                     /translation="MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEG
                     GRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHG
                     AAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESF
                     AIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGG
                     NVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYA
                     ISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAE
                     SASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNN
                     EACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPS
                     GSIDECNVETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAV
                     GYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFL
                     GKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYV
                     FRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLASARPGPGV
                     PATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC
                     NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTG
                     TTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNT
                     AGFYCDRCKDGFFGNPLAPNPADKCKACNCNPYGTMKQQSSCNPVTGQCECLPHVTGQ
                     DCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNH
                     FGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQE
                     CPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLRE
                     AQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIE
                     IASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTA
                     NDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGD
                     KAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELE
                     VKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVN
                     DNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAV
                     QKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQ
                     AAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVS
                     DLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP"
     sig_peptide     300..398
                     /gene="LAMC1"
     mat_peptide     399..5126
                     /gene="LAMC1"
                     /product="laminin, gamma 1"
     misc_feature    399..1154
                     /gene="LAMC1"
                     /note="N-terminal domain; Region: Domain VI"
     misc_feature    1155..1826
                     /gene="LAMC1"
                     /note="contains 4.5 EGF-like repeats; Region: Domain V"
     misc_feature    1827..2366
                     /gene="LAMC1"
                     /note="Region: Domain IV"
     misc_feature    2367..3389
                     /gene="LAMC1"
                     /note="contains 6.5 EGF-like repeats; Region: Domain III"
     misc_feature    3390..5126
                     /gene="LAMC1"
                     /note="C-terminal domain; Region: Domain I/II"
     polyA_signal    5330..5335
                     /gene="LAMC1"
     polyA_site      5346
                     /gene="LAMC1"
     polyA_signal    5633..5638
                     /gene="LAMC1"
     polyA_signal    7578..7583
                     /gene="LAMC1"
     polyA_signal    7838..7843
                     /gene="LAMC1"
     polyA_signal    7894..7899
                     /gene="LAMC1"
                     /note="multiple polyA_signals are potentially used to
                     generate the 2 sets of mRNAs (5.5 and 7.5 kb) seen on
                     Northern analysis"
ORIGIN      
        1 gcgcactcgg gcacgcgctc ggaagtcggg ggtcggcgcg gagtgcaggc tgctcccggg
       61 gtaggtgagg gaagcgcgga ggcggggcgc gggggcagtg gtcggcgagc agcgcggtcc
      121 tcgctagggg cgcccacccg tcagtctctc cggcgcgagc cgccgccacc gcccgcgccg
      181 gagtcaggcc cctgggcccc caggctcaag cagcgaagcg gcctccgggg gacgccgcta
      241 ggcgagagga acgcgccggt gcccttgcct tcgccgtgac ccagcgtgcg ggcggcggga
      301 tgagagggag ccatcgggcc gcgccggccc tgcggccccg ggggcggctc tggcccgtgc
      361 tggccgtgct ggcggcggcc gccgcggcgg gctgtgccca ggcagccatg gacgagtgca
      421 cggacgaggg cgggcggccg cagcgctgca tgcccgagtt cgtcaacgcc gctttcaacg
      481 tgactgtggt ggccaccaac acgtgtggga ctccgcccga ggaatactgt gtgcagaccg
      541 gggtgaccgg ggtcaccaag tcctgtcacc tgtgcgacgc cgggcagccc cacctgcagc
      601 acggggcagc cttcctgacc gactacaaca accaggccga caccacctgg tggcaaagcc
      661 agaccatgct ggccggggtg cagtacccca gctccatcaa cctcacgctg cacctgggaa
      721 aagcttttga catcacctat gtgcgtctca agttccacac cagccgcccg gagagctttg
      781 ccatttacaa gcgcacacgg gaagacgggc cctggattcc ttaccagtac tacagtggtt
      841 cctgcgagaa cacctactcc aaggcaaacc gcggcttcat caggacagga ggggacgagc
      901 agcaggcctt gtgtactgat gaattcagtg acatttctcc cctcactggg ggcaacgtgg
      961 ccttttctac cctggaagga aggcccagcg cctataactt tgacaatagc cctgtgctgc
     1021 aggaatgggt aactgccact gacatcagag taactcttaa tcgcctgaac acttttggag
     1081 atgaagtgtt taacgatccc aaagttctca agtcctatta ttatgccatc tctgattttg
     1141 ctgtaggtgg cagatgtaaa tgtaatggac acgcaagcga gtgtatgaag aacgaatttg
     1201 ataagctggt gtgtaattgc aaacataaca catatggagt agactgtgaa aagtgtcttc
     1261 ctttcttcaa tgaccggccg tggaggaggg caactgcgga aagtgccagt gaatgcctgc
     1321 cctgtgattg caatggtcga tcccaggaat gctacttcga ccctgaactc tatcgttcca
     1381 ctggccatgg gggccactgt accaactgcc aggataacac agatggcgcc cactgtgaga
     1441 ggtgccgaga gaacttcttc cgccttggca acaatgaagc ctgctcttca tgccactgta
     1501 gtcctgtggg ctctctaagc acacagtgtg atagttacgg cagatgcagc tgtaagccag
     1561 gagtgatggg ggacaaatgt gaccgttgcc agcctggatt ccattctctc actgaagcag
     1621 gatgcaggcc atgctcttgt gatccctctg gcagcataga tgaatgtaat gttgaaacag
     1681 gaagatgtgt ttgcaaagac aatgtcgaag gcttcaattg tgaaagatgc aaacctggat
     1741 tttttaatct ggaatcatct aatcctcggg gttgcacacc ctgcttctgc tttgggcatt
     1801 cttctgtctg tacaaacgct gttggctaca gtgtttattc tatctcctct acctttcaga
     1861 ttgatgagga tgggtggcgt gcggaacaga gagatggctc tgaagcatct ctcgagtggt
     1921 cctctgagag gcaagatatc gccgtgatct cagacagcta ctttcctcgg tacttcattg
     1981 ctcctgcaaa gttcttgggc aagcaggtgt tgagttatgg tcagaacctc tccttctcct
     2041 ttcgagtgga caggcgagat actcgcctct ctgccgaaga ccttgtgctt gagggagctg
     2101 gcttaagagt atctgtaccc ttgatcgctc agggcaattc ctatccaagt gagaccactg
     2161 tgaagtatgt cttcaggctc catgaagcaa cagattaccc ttggaggcct gctcttaccc
     2221 cttttgaatt tcagaagctc ctaaacaact tgacctctat caagatacgt gggacataca
     2281 gtgagagaag tgctggatat ttggatgatg tcaccctggc aagtgctcgt cctgggcctg
     2341 gagtccctgc aacttgggtg gagtcctgca cctgtcctgt gggatatgga gggcagtttt
     2401 gtgagatgtg cctctcaggt tacagaagag aaactcctaa tcttggacca tacagtccat
     2461 gtgtgctttg cgcctgcaat ggacacagcg agacctgtga tcctgagaca ggtgtttgta
     2521 actgcagaga caatacggct ggcccgcact gtgagaagtg cagtgatggg tactatggag
     2581 attcaactgc aggcacctcc tccgattgcc aaccctgtcc gtgtcctgga ggttcaagtt
     2641 gtgctgttgt tcccaagaca aaggaggtgg tgtgcaccaa ctgtcctact ggcaccactg
     2701 gtaagagatg tgagctctgt gatgatggct actttggaga ccccctgggt agaaacggcc
     2761 ctgtgagact ttgccgcctg tgccagtgca gtgacaacat cgatcccaac gcagttggaa
     2821 attgcaatcg cttgacggga gaatgcctga agtgcatcta taacactgct ggcttctatt
     2881 gtgaccggtg caaagacgga ttttttggaa atcccctggc tcccaatcca gcagacaaat
     2941 gcaaagcctg caattgcaat ccgtatggga ccatgaagca gcagagcagc tgtaaccccg
     3001 tgacggggca gtgtgaatgt ttgcctcacg tgactggcca ggactgtggt gcttgtgacc
     3061 ctggattcta caatctgcag agtgggcaag gctgtgagag gtgtgactgc catgccttgg
     3121 gctccaccaa tgggcagtgt gacatccgca ccggccagtg tgagtgccag cccggcatca
     3181 ctggtcagca ctgtgagcgc tgtgaggtca accactttgg gtttggacct gaaggctgca
     3241 aaccctgtga ctgtcatcct gagggatctc tttcacttca gtgcaaagat gatggtcgct
     3301 gtgaatgcag agaaggcttt gtgggaaatc gctgtgacca gtgtgaagaa aactatttct
     3361 acaatcggtc ttggcctggc tgccaggaat gtccagcttg ttaccggctg gtaaaggata
     3421 aggttgctga tcatagagtg aagctccagg aattagagag tctcatagca aaccttggaa
     3481 ctggggatga gatggtgaca gatcaagcct tcgaggatag actaaaggaa gcagagaggg
     3541 aagttatgga cctccttcgt gaggcccagg atgtcaaaga tgttgaccag aatttgatgg
     3601 atcgcctaca gagagtgaat aacactctgt ccagccaaat tagccgttta cagaatatcc
     3661 ggaataccat tgaagagact ggaaacttgg ctgaacaagc gcgtgcccat gtagagaaca
     3721 cagagcggtt gattgaaatc gcatccagag aacttgagaa agcaaaagtc gctgctgcca
     3781 atgtgtcagt cactcagcca gaatctacag gggacccaaa caacatgact cttttggcag
     3841 aagaggctcg aaagcttgct gaacgtcata aacaggaagc tgatgacatt gttcgagtgg
     3901 caaagacagc caatgatacg tcaactgagg catacaacct gcttctgagg acactggcag
     3961 gagaaaatca aacagcattt gagattgaag agcttaatag gaagtatgaa caagcgaaga
     4021 acatctcaca ggatctggaa aaacaagctg cccgagtaca tgaggaggcc aaaagggccg
     4081 gtgacaaagc tgtggagatc tatgccagcg tggctcagct gagccctttg gactctgaga
     4141 cactggagaa tgaagcaaat aacataaaga tggaagctga gaatctggaa caactgattg
     4201 accagaaatt aaaagattat gaggacctca gagaagatat gagagggaag gaacttgaag
     4261 tcaagaacct tctggagaaa ggcaagactg aacagcagac cgcagaccaa ctcctagccc
     4321 gagctgatgc tgccaaggcc ctcgctgaag aagctgcaaa gaagggacgg gataccttac
     4381 aagaagctaa tgacattctc aacaacctga aagattttga taggcgcgtg aacgataaca
     4441 agacggccgc agaggaggca ctaaggaaga ttcctgccat caaccagacc atcactgaag
     4501 ccaatgaaaa gaccagagaa gcccagcagg ccctgggcag tgctgcggcg gatgccacag
     4561 aggccaagaa caaggcccat gaggcggaga ggatcgcaag cgctgtccaa aagaatgcca
     4621 ccagcaccaa ggcagaagct gaaagaactt ttgcagaagt tacagatctg gataatgagg
     4681 tgaacaatat gttgaagcaa ctgcaggaag cagaaaaaga gctaaagaga aaacaagatg
     4741 acgctgacca ggacatgatg atggcaggga tggcttcaca ggctgctcaa gaagccgaga
     4801 tcaatgccag aaaagccaaa aactctgtta ctagcctcct cagcattatt aatgacctct
     4861 tggagcagct ggggcagctg gatacagtgg acctgaataa gctaaacgag attgaaggca
     4921 ccctaaacaa agccaaagat gaaatgaagg tcagcgatct tgataggaaa gtgtctgacc
     4981 tggagaatga agccaagaag caggaggctg ccatcatgga ctataaccga gatatcgagg
     5041 agatcatgaa ggacattcgc aatctggagg acatcaggaa gaccttacca tctggctgct
     5101 tcaacacccc gtccattgaa aagccctagt gtctttaggg ctggaaggca gcatccctct
     5161 gacagggggg cagttgtgag gccacagagt gccttgacac aaagattaca tttttcagac
     5221 ccccactcct ctgctgctgt ccatcactgt ccttttgaac caggaaaagt cacagagttt
     5281 aaagagaagc aaattaaaca tcctgaatcg ggaacaaagg gttttatcta ataaagtgtc
     5341 tcttccatca cgttgctacc ttacccacac ttccctctga tttgcgtgag gacgtggcat
     5401 cctacttacg tacgtggcat aacacatcgt gtgagcccat gtatgctggg gtagagcaag
     5461 tagccctccc ctgtctcatc gatccagcag aacctcctca gtctcagtac tcttgtttct
     5521 ataaggaaaa gttttgctac taacagtagc attgtgatgg ccagtatatc cagtccatgg
     5581 ataaagaaaa tgcatctgca tctcctgccc ctcttccttc taagcaaaag gaaataaaca
     5641 tcctgtgcca aaggtattgg tcatttagaa tgtcggtagc catccatcag tgcttttagc
     5701 tattatgagt gtaggacact gagccatccg tgggtcagga tgcaattatt tataaaagtc
     5761 cccaggtgaa catggctgaa gatttttcta gtatattaat aattgactag gaagatgaac
     5821 tttttttcag atctttgggc agctgataat ttaaatctgg atgggcagct tgcactcacc
     5881 aatagaccaa aagacatctt ttgatattct tataaatgga acttacacag aagaaatagg
     5941 gatatgataa ccactaaagt tttgttttca aaatcaaact aattcttaca gcttttttat
     6001 tagttagtct tggaactagt gttaagtatc tggcagagaa cagttaatcc ctaaggtctt
     6061 gacaaaacag aagaaaaaca agcctcctcg tcctagtctt ttctagcaaa gggataaaac
     6121 ttagatggca gcttgtactg tcagaatccc gtgtatccat ttgttcttct gttggagaga
     6181 tgagacattt gacccttagc tccagttttc ttctgatgtt tccatcttcc agaatccctc
     6241 aaaaaacatt gtttgccaaa tcctggtggc aaatacttgc actcagtatt tcacacagct
     6301 gccaacgcta tcgagttcct gcactttgtg atttaaatcc actctaaacc ttccctctaa
     6361 gtgtagaggg aagaccctta cgtggagttt cctagtgggc ttctcaactt ttgatcctca
     6421 gctctgtggt tttaagacca cagtgtgaca gttccctgcc acacaccccc ttcctcctac
     6481 caacccacct ttgagattca tatatagcct ttaacactat gcaactttgt actttgcgta
     6541 gcaggggctg gggtgggggg aaagaaacct attatcatgg acacactggt gctattaatt
     6601 atttcaaatt tatatttttg tgtgaatgtt ttgtgttttg tttatccatg ctatagaaca
     6661 aggaatttat gtagatatac ttagtcctat ttctagaatg acactctgtt cactttgctc
     6721 aatttttcct cttcactggc acaagtatct gaatacctcc ttccctccct tctagagttc
     6781 tttggattgt actccaaaga attgtgcctt gtgtttgcag catctccatt ctctaaatta
     6841 atataattgc tttcctccac acccagccac gtaaagaggt aacttgggtc ctcttccatt
     6901 gcagtcctga tgatcctaac ctgcagcacg gtggttttac aatgttccag agcaggaacg
     6961 ccaggttgac aagctatggt aggattagga aagtttgctg aagaggatct ttgacgccac
     7021 agtgggacta gccaggaatg agggagaaat gccctttttg gcaattgttg gagctggata
     7081 ggtaagtttt ataagggagt acattttgac tgagcactta gggcatcagg aacagtgcta
     7141 cttactggtg ggtagactgg gagaggtggt gtaacttagt tcttgatgat cccacttcct
     7201 gtttccatct gcttgggata taccagagtt taccacaagt gttttgacga tatactcctg
     7261 agctttcact ctgctggctt ctcccaggcc tcttctacta tggcaggaga tgtggtgtgc
     7321 tgttgcaaag ttttcacgtc atcgtttcct ggctagttca tttcattaag tggctacatc
     7381 ctaacatatg cattggtcaa ggttgcagca agaggactga agattgactg ccaagctagt
     7441 ttgggtgaag ttcactccag caagtctcag gccacaatgg ggtggtttgg tttggtttcc
     7501 ttttaacttt ctttttgtta tttgcttttc tcctccacct gtgtggtata ttttttaagc
     7561 agaattttat tttttaaaat aaaaggttct ttacaagatg ataccttaat tacactcccg
     7621 caacacagcc attattttat tgtctagctc cagttatctg tattttatgt aatgtaattg
     7681 acaggatggc tgctgcagaa tgctggttga cacagggatt attatactgc tatttttccc
     7741 tgaattcttt tccttggaat tccaactgtg gaccttttat atgtgccttc actttagctg
     7801 tttgccttac tctacagcct tgctctccgg ggtggttaat aaaatgcaac acttggcatt
     7861 tttatgttat aagaaaaaca gtattttatt tataataaaa tctgaatatt ttgtaaccct
     7921 tta
//

LOCUS       NM_002372               5128 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens mannosidase, alpha, class 2A, member 1 (MAN2A1), mRNA.
ACCESSION   NM_002372
VERSION     NM_002372.2  GI:51477713
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5128)
  AUTHORS   Chui,D., Sellakumar,G., Green,R., Sutton-Smith,M., McQuistan,T.,
            Marek,K., Morris,H., Dell,A. and Marth,J.
  TITLE     Genetic remodeling of protein glycosylation in vivo induces
            autoimmune disease
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (3), 1142-1147 (2001)
   PUBMED   11158608
  REMARK    GeneRIF: This article discribes experiments in which the MAN2A1
            homologue in mouse was deleted, resulting in a systemic autoimmune
            disease in the mice which is similar to human systemic lupus
            erythematosus.
REFERENCE   2  (bases 1 to 5128)
  AUTHORS   Misago,M., Liao,Y.F., Kudo,S., Eto,S., Mattei,M.G., Moremen,K.W.
            and Fukuda,M.N.
  TITLE     Molecular cloning and expression of cDNAs encoding human
            alpha-mannosidase II and a previously unrecognized
            alpha-mannosidase IIx isozyme
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11766-11770 (1995)
   PUBMED   8524845
REFERENCE   3  (bases 1 to 5128)
  AUTHORS   Moremen,K.W. and Robbins,P.W.
  TITLE     Isolation, characterization, and expression of cDNAs encoding
            murine alpha-mannosidase II, a Golgi enzyme that controls
            conversion of high mannose to complex N-glycans
  JOURNAL   J. Cell Biol. 115 (6), 1521-1534 (1991)
   PUBMED   1757461
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX341412.2, BC031659.1,
            D63998.1, U31520.1, BC043416.1, AL833486.1 and BX643508.1.
            On Aug 20, 2004 this sequence version replaced gi:4758697.
            
            Summary: This gene encodes a protein which is a member of family 38
            of the glycosyl hydrolases. The protein is located in the Golgi and
            catalyzes the final hydrolytic step in the asparagine-linked
            oligosaccharide (N-glycan) maturation pathway. Mutations in the
            mouse homolog of this gene have been shown to cause a systemic
            autoimmune disease similar to human systemic lupus erythematosus.
FEATURES             Location/Qualifiers
     source          1..5128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21-q22"
     gene            1..5128
                     /gene="MAN2A1"
                     /note="synonyms: MANA2, MANII"
                     /db_xref="GeneID:4124"
                     /db_xref="MIM:154582"
     CDS             964..4398
                     /gene="MAN2A1"
                     /EC_number="3.2.1.114"
                     /note="mannosidase, alpha type II; Golgi alpha-mannosidase
                     II; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     NR];
                     go_component: membrane fraction [goid 0005624] [evidence
                     NR];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: alpha-mannosidase activity [goid 0004559]
                     [evidence IEA];
                     go_function: hydrolase activity, acting on glycosyl bonds
                     [goid 0016798] [evidence IEA];
                     go_function: mannosyl-oligosaccharide
                     1,3-1,6-alpha-mannosidase activity [goid 0004572]
                     [evidence TAS] [pmid 8524845];
                     go_process: carbohydrate metabolism [goid 0005975]
                     [evidence IEA];
                     go_process: glycoprotein biosynthesis [goid 0009101]
                     [evidence NR]"
                     /codon_start=1
                     /product="mannosidase, alpha, class 2A, member 1"
                     /protein_id="NP_002363.2"
                     /db_xref="GI:51477714"
                     /db_xref="GeneID:4124"
                     /db_xref="MIM:154582"
                     /translation="MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFP
                     QGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHL
                     LPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNE
                     WDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISY
                     LSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEN
                     NIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQ
                     NWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIH
                     PGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMN
                     SQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYF
                     TSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLF
                     QHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLE
                     MDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKP
                     VEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKV
                     EDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGT
                     TIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQG
                     IEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQA
                     NVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQD
                     NKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLE
                     LQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFC
                     STTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR"
ORIGIN      
        1 gcgggcggtg ctggagcgcc aagtggcgct ggagaaccgg cgcttccttt cgccgcttcc
       61 gccgccatct ccgcgtttgt ggggcgggaa agagggaggg ggctagcggc tgcagctgga
      121 gcgggcttct ctccggggac ggtcctttcc tccctgctct ccttttcctt ctttccgcgt
      181 tgccgccgcc cgccccctgc gcctccccgc ggagcctggg tccgggaggg ggaaggtagg
      241 ggcggcgggg ggcgggagag tctggcgagc ggacgctagc tctgaggaaa ctcatcaatc
      301 cgtgagcccc ggagtccggg gtgcacatcg gcccagccgc agcgtcggcg gcggcggcgg
      361 cagcagcacg aaggggctca gtcggggtag gcgggggcgg tgccggtgcc gcgggggcgg
      421 gcccgaccgt cccgcccaga agttgtaggg cttggctcct cgcgatcttg ttcctttccc
      481 ctccgcttct ctgacctagc tgcgcggccc cggcccggga gctgccgaac ccgcgcctcc
      541 cctgggtgag gaggacacgc ctgccctcgt cgagaaaact tttcctgccg actcagttgg
      601 ggcggcggtg gcaggaagtg cgggcagcga cctctcctcc gcctgccccg cgcgccctgc
      661 cggaggtcgg cgctgagctt gcgatcaagt ttgtgggggc cccccttccc agttgccggc
      721 gagtctcgcc tcgagagggg cgcccgaccc cggggagggc ggcaggccag ggcgaaggcc
      781 aagggcgtgt ggtggcgccg gagactaggt gcggagcaag gcggggactc gcacccgcat
      841 ccgagagcgc ggaggtcgcg cagcccggga gaagggagcc tccggcggct gcttcctaga
      901 gtccacagtg cgctgtctcc tttggctgag gagagtgtcc tggccccgag tctatcgagg
      961 aaaatgaagt taagccgcca gttcaccgtg ttcggcagtg cgatcttctg tgtggtgatt
     1021 ttctcgctct acctgatgct ggaccggggt cacttagact accccaggaa cccgcgccgc
     1081 gagggctcct tccctcaggg ccagctctca atgttgcaag aaaaaataga ccatttggag
     1141 cgtttgctag ctgagaataa tgagatcatc tcaaatatta gagactcagt catcaatttg
     1201 agtgagtctg tggaggatgg tccgaaaagt tcacaaagca atttcagcca aggtgctggc
     1261 tcacatcttc tgccctcaca attatccctc tcagttgaca ctgcagactg tctgtttgct
     1321 tcacaaagtg gaagtcacaa ttcagatgtg cagatgttgg atgtttacag tctaatttct
     1381 tttgacaatc cagatggtgg agtttggaag caaggatttg acattactta tgaatctaat
     1441 gaatgggaca ctgaacccct tcaagtcttt gtggtgcctc attcccataa cgacccaggt
     1501 tggttgaaga ctttcaatga ctactttaga gacaagactc agtatatttt taataacatg
     1561 gtcctaaagc tgaaagaaga ctcacggagg aagtttattt ggtctgagat ctcttacctt
     1621 tcaaagtggt gggatattat agatattcag aagaaggatg ctgttaaaag tttaatagaa
     1681 aatggtcagc ttgaaattgt gacaggtggc tgggttatgc ctgatgaagc tactccacat
     1741 tattttgcct taattgatca actaattgaa ggacatcagt ggctggaaaa taatatagga
     1801 gtgaaacctc ggtccggctg ggctattgat ccctttggac actcaccaac aatggcttat
     1861 cttctaaacc gtgctggact ttctcacatg cttatccaga gagttcatta tgcagttaaa
     1921 aaacactttg cactgcataa aacattggag tttttttgga gacagaattg ggatctggga
     1981 tctgtcacag atattttatg ccacatgatg cccttctaca gctatgacat ccctcacact
     2041 tgtggacctg atcctaaaat atgctgccag tttgatttta aacgtcttcc tggaggcaga
     2101 tttggttgtc cctggggagt ccccccagaa acaatacatc ctggaaatgt ccaaagcagg
     2161 gctcggatgc tactagatca gtaccgaaag aagtcaaagc tttttcgtac caaagttctc
     2221 ctggctccac taggagatga tttccgctac tgtgaataca cggaatggga tttacagttt
     2281 aagaattatc agcagctttt tgattatatg aattctcagt ccaagtttaa agttaagata
     2341 cagtttggaa ctttatcaga tttttttgat gcgctggata aagcagatga aactcagaga
     2401 gacaagggcc aatcgatgtt ccctgtttta agtggagatt ttttcactta tgccgatcga
     2461 gatgatcatt actggagtgg ctattttaca tccagaccct tttacaaacg aatggacaga
     2521 atcatggaat ctcatttaag ggctgctgaa attctttact atttcgccct gagacaagct
     2581 cacaaataca agataaataa atttctctca tcatcacttt acacggcact gacagaagcc
     2641 agaaggaatt tgggactgtt tcaacatcat gatgctatca caggaactgc aaaagactgg
     2701 gtggttgtgg attatggtac cagacttttt cattcgttaa tggttttgga gaagataatt
     2761 ggaaattctg catttcttct tattttgaag gacaaactca catacgactc ttactctcct
     2821 gataccttcc tggagatgga tttgaaacaa aaatcacaag attctctgcc acaaaaaaat
     2881 ataataaggc tgagtgcgga gccaaggtac cttgtggtct ataatccttt agaacaagac
     2941 cgaatctcgt tggtctcagt ctatgtgagt tccccgacag tgcaagtgtt ctctgcttca
     3001 ggaaaacctg tggaagttca agtcagcgca gtttgggata cagcaaatac tatttcagaa
     3061 acagcctatg agatctcttt tcgagcacat ataccgccat tgggactgaa agtgtataag
     3121 attttggaat cagcaagttc aaattcacat ttagctgatt atgtcttgta taagaataaa
     3181 gtagaagata gcggaatttt caccataaag aatatgataa atactgaaga aggtataaca
     3241 ctagagaact cctttgtttt acttcggttt gatcaaactg gacttatgaa gcaaatgatg
     3301 actaaagaag atggtaaaca ccatgaagta aatgtgcaat tttcatggta tggaaccaca
     3361 attaaaagag acaaaagtgg tgcctacctc ttcttacctg atggtaatgc caagccttat
     3421 gtttacacaa caccgccctt tgtcagagtg acacatggaa ggatttattc ggaagtgact
     3481 tgcttttttg accatgttac tcatagagtc cgactatacc acatacaggg aatagaagga
     3541 cagtctgtgg aagtttccaa tattgtggac atccgaaaag tatataaccg tgagattgca
     3601 atgaaaattt cttctgatat aaaaagccaa aatagatttt atactgacct aaatgggtac
     3661 cagattcaac ctagaatgac actgagcaaa ttgcctcttc aagcaaatgt ctatcccatg
     3721 accacaatgg cctatatcca ggatgccaaa catcgtttga cactgctctc tgctcagtca
     3781 ttaggggttt cgagtttgaa tagtggtcag attgaagtta tcatggatcg aagactcatg
     3841 caagatgata atcgtggcct tgagcaaggt atccaggata acaagattac agctaatcta
     3901 tttcgaatac tactagaaaa aagaagtgct gttaatacgg aagaagaaaa gaagtcggtc
     3961 agttatcctt ctctccttag ccacataact tcttctctca tgaatcatcc agtcattcca
     4021 atggcaaata agttctcctc acctaccctt gagctgcaag gtgaattctc tccattacag
     4081 tcatctttgc cttgtgacat tcatctggtt aatttgagaa caatacagtc aaaggtgggc
     4141 aatgggcact ccaatgaggc agccttgatc ctccacagaa aagggtttga ttgtcggttc
     4201 tctagcaaag gcacagggct gttttgttct actactcagg gaaagatatt ggtacagaaa
     4261 cttttaaaca agtttattgt cgaaagtctc acaccttcat cactatcctt gatgcattca
     4321 cctcccggca ctcagaatat aagtgagatc aacttgagtc caatggaaat cagcacattc
     4381 cgaatccagt tgaggtgaac ctgactttca catttggatt gagaatcatt ggcttttata
     4441 cctttcttgg tttgacgtgc aataaagaag cacattattt tagcttctgg ctactgtgag
     4501 aacatgaatt ctgtgattct gtgggttttt tcttttttct tttaccagta cagtaagaaa
     4561 aaaaaaaaaa aaaaaaaagc catgctatca atcaagattc ttttttttta aactttctcc
     4621 catgaactac caccatcagt atgaattgat gcaacaaatg aagaaatatt taaagacagc
     4681 ctctcaacag attgtatctc aggttaaatg ctaactaatt atgtctgtgt tgggggttgc
     4741 gaagagattc ttaaaagtat ctgtgtgttg atcatcagtt ttacaaaaac acctatttgg
     4801 ctgaaatgga ataaaatgtt tgtgggtaaa agctaatggc caaaatggtt gcaatcattc
     4861 atactagtta gaaaaattat gtgttgaaat aagtggaaaa gtgcaatcca tccaccctta
     4921 tgattaacgt agatgatttt tatacctttt tctgatgtac ctcttgacct tctccttccc
     4981 ttcctaccct ttctaagtat ttccagaaat acctgatttt gaatcattca acagtagaaa
     5041 aagaggcata ttttcattac ttgacaatgt gggatgggtg caatttattc catcttcact
     5101 aaaatagaag caattccata ggtaccat
//

LOCUS       NM_002473               7474 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens myosin, heavy polypeptide 9, non-muscle (MYH9), mRNA.
ACCESSION   NM_002473
VERSION     NM_002473.3  GI:51317362
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7474)
  AUTHORS   Matsushita,T., Hayashi,H., Kunishima,S., Hayashi,M., Ikejiri,M.,
            Takeshita,K., Yuzawa,Y., Adachi,T., Hirashima,K., Sone,M.,
            Yamamoto,K., Takagi,A., Katsumi,A., Kawai,K., Nezu,T.,
            Takahashi,M., Nakashima,T., Naoe,T., Kojima,T. and Saito,H.
  TITLE     Targeted disruption of mouse ortholog of the human MYH9 responsible
            for macrothrombocytopenia with different organ involvement:
            hematological, nephrological, and otological studies of
            heterozygous KO mice
  JOURNAL   Biochem. Biophys. Res. Commun. 325 (4), 1163-1171 (2004)
   PUBMED   15555549
  REMARK    GeneRIF: Here targeted gene disruption was performed to understand
            fundamental as well as pathological role of the gene for NMMHCA,
            MYH9.
REFERENCE   2  (bases 1 to 7474)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol. 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   3  (bases 1 to 7474)
  AUTHORS   Lamant,L., Gascoyne,R.D., Duplantier,M.M., Armstrong,F., Raghab,A.,
            Chhanabhai,M., Rajcan-Separovic,E., Raghab,J., Delsol,G. and
            Espinos,E.
  TITLE     Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in
            anaplastic large cell lymphoma
  JOURNAL   Genes Chromosomes Cancer 37 (4), 427-432 (2003)
  MEDLINE   22683269
   PUBMED   12800156
  REMARK    GeneRIF: In a case of anaplastic large cell lymphoma, a portion of
            MYH9 is found to be fused to the ALK gene in a novel chromosomal
            abnormality, t(2;22)(p23;q11.2).
REFERENCE   4  (bases 1 to 7474)
  AUTHORS   Deutsch,S., Rideau,A., Bochaton-Piallat,M.L., Merla,G., Geinoz,A.,
            Gabbiani,G., Schwede,T., Matthes,T., Antonarakis,S.E. and Beris,P.
  TITLE     Asp1424Asn MYH9 mutation results in an unstable protein responsible
            for the phenotypes in May-Hegglin anomaly/Fechtner syndrome
  JOURNAL   Blood 102 (2), 529-534 (2003)
  MEDLINE   22718684
   PUBMED   12649151
  REMARK    GeneRIF: The Asp1424Asn mutation in the MYH9 gene causes the
            May-Hegglin anomaly, Fechtner syndrome, Sebastian syndrome, &
            Epstein syndrome, which result from a highly unstable protein &
            failure to reorganize the megakaryocyte cytoskeleton for platelet
            production.
REFERENCE   5  (bases 1 to 7474)
  AUTHORS   Seri,M., Pecci,A., Di Bari,F., Cusano,R., Savino,M., Panza,E.,
            Nigro,A., Noris,P., Gangarossa,S., Rocca,B., Gresele,P.,
            Bizzaro,N., Malatesta,P., Koivisto,P.A., Longo,I., Musso,R.,
            Pecoraro,C., Iolascon,A., Magrini,U., Rodriguez Soriano,J.,
            Renieri,A., Ghiggeri,G.M., Ravazzolo,R., Balduini,C.L. and
            Savoia,A.
  TITLE     MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome,
            Fechtner syndrome, and Epstein syndrome are not distinct entities
            but represent a variable expression of a single illness
  JOURNAL   Medicine (Baltimore) 82 (3), 203-215 (2003)
  MEDLINE   22676762
   PUBMED   12792306
  REMARK    GeneRIF: MYH9 gene is implicated in May-Hegglin anomaly, Sebastian
            syndrome, Fechtner syndrome and Epstein syndrome which are
            autosomal dominant macrothrombocytopenias.
REFERENCE   6  (bases 1 to 7474)
  AUTHORS   Mhatre,A.N., Kim,Y., Brodie,H.A. and Lalwani,A.K.
  TITLE     Macrothrombocytopenia and progressive deafness is due to a mutation
            in MYH9
  JOURNAL   Otol. Neurotol. 24 (2), 205-209 (2003)
  MEDLINE   22508750
   PUBMED   12621333
  REMARK    GeneRIF: A single base pair transition in MYH9, resulting in an
            amino acid substitution D1424N, is responsible for
            macrothrombocytopenia and hearing loss in the kindred under study.
REFERENCE   7  (bases 1 to 7474)
  AUTHORS   Ghiggeri,G.M., Caridi,G., Magrini,U., Sessa,A., Savoia,A., Seri,M.,
            Pecci,A., Romagnoli,R., Gangarossa,S., Noris,P., Sartore,S.,
            Necchi,V., Ravazzolo,R. and Balduini,C.L.
  TITLE     Genetics, clinical and pathological features of glomerulonephritis
            associated with mutations of nonmuscle myosin IIA (Fechtner
            syndrome)
  JOURNAL   Am. J. Kidney Dis. 41 (1), 95-104 (2003)
  MEDLINE   22386817
   PUBMED   12500226
  REMARK    GeneRIF: A major role is indicated for the NMMHC-IIA abnormality in
            the pathogenesis of leukocyte, platelet, and kidney defects in
            Fechtner syndrome.
REFERENCE   8  (bases 1 to 7474)
  AUTHORS   Takubo,T., Wakui,S., Daigo,K., Kurokata,K., Ohashi,T., Katayama,K.
            and Hino,M.
  TITLE     Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in
            mammalian cells
  JOURNAL   Blood 47 (4), 345-352 (2003)
   PUBMED   14706930
  REMARK    GeneRIF: Myosin heavy polypeptide 9 (MYH9) colocalizes with actin
            stress fibers in mammalian cells.
REFERENCE   9  (bases 1 to 7474)
  AUTHORS   Rey,M., Vicente-Manzanares,M., Viedma,F., Y, Urzainqui,A.,
            Barreiro,O., V and S.
  TITLE     Cutting edge: association of the motor protein nonmuscle myosin
            heavy chain-IIA with the C terminus of the chemokine receptor CXCR4
            in T lymphocytes
  JOURNAL   J. Immunol. 169 (10), 5410-5414 (2002)
  MEDLINE   22309087
   PUBMED   12421915
  REMARK    GeneRIF: Motor protein nonmuscle myosin heavy chain-IIA and CXCR$
            colocalize at the leading edge of migrating T lymphocytes, together
            with filamentous actin and myosin light chain.
REFERENCE   10 (bases 1 to 7474)
  AUTHORS   Seri,M., Savino,M., Bordo,D., Cusano,R., Rocca,B., Meloni,I., Di
            Bari,F., Koivisto,P.A., Bolognesi,M., Ghiggeri,G.M., Landolfi,R.,
            Balduini,C.L., Zelante,L., Ravazzolo,R., Renieri,A. and Savoia,A.
  TITLE     Epstein syndrome: another renal disorder with mutations in the
            nonmuscle myosin heavy chain 9 gene
  JOURNAL   Hum. Genet. 110 (2), 182-186 (2002)
  MEDLINE   21932559
   PUBMED   11935325
  REMARK    GeneRIF: mutation in epstein syndrome
REFERENCE   11 (bases 1 to 7474)
  AUTHORS   Heath,K.E., Campos-Barros,A., Toren,A., Rozenfeld-Granot,G.,
            Carlsson,L.E., Savige,J., Denison,J.C., Gregory,M.C., White,J.G.,
            Barker,D.F., Greinacher,A., Epstein,C.J., Glucksman,M.J. and
            Martignetti,J.A.
  TITLE     Nonmuscle myosin heavy chain IIA mutations define a spectrum of
            autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and
            Fechtner, Sebastian, Epstein, and Alport-like syndromes
  JOURNAL   Am. J. Hum. Genet. 69 (5), 1033-1045 (2001)
  MEDLINE   21473756
   PUBMED   11590545
  REMARK    GeneRIF: mutations cause a spectrum of autosomal dominant
            macrothrombocytopenias: May-Hegglin anomaly and Fechtner,
            Sebastian, Epstein, and Alport-like syndromes; hence, the name
            'MYHIIA syndrome' is proposed to encompass all of these disorders
REFERENCE   12 (bases 1 to 7474)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (14), 6549-6553 (1994)
  MEDLINE   94294418
   PUBMED   8022818
REFERENCE   13 (bases 1 to 7474)
  AUTHORS   Toothaker,L.E., Gonzalez,D.A., Tung,N., Lemons,R.S., Le Beau,M.M.,
            Arnaout,M.A., Clayton,L.K. and Tenen,D.G.
  TITLE     Cellular myosin heavy chain in human leukocytes: isolation of 5'
            cDNA clones, characterization of the protein, chromosomal
            localization, and upregulation during myeloid differentiation
  JOURNAL   Blood 78 (7), 1826-1833 (1991)
  MEDLINE   92003925
   PUBMED   1912569
REFERENCE   14 (bases 1 to 7474)
  AUTHORS   Simons,M., Wang,M., McBride,O.W., Kawamoto,S., Yamakawa,K.,
            Gdula,D., Adelstein,R.S. and Weir,L.
  TITLE     Human nonmuscle myosin heavy chains are encoded by two genes
            located on different chromosomes
  JOURNAL   Circ. Res. 69 (2), 530-539 (1991)
  MEDLINE   91316803
   PUBMED   1860190
REFERENCE   15 (bases 1 to 7474)
  AUTHORS   Saez,C.G., Myers,J.C., Shows,T.B. and Leinwand,L.A.
  TITLE     Human nonmuscle myosin heavy chain mRNA: generation of diversity
            through alternative polyadenylylation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (3), 1164-1168 (1990)
  MEDLINE   90138958
   PUBMED   1967836
REFERENCE   16 (bases 1 to 7474)
  AUTHORS   Lee,C.L. and Atassi,M.Z.
  TITLE     Enzymic and immunochemical properties of lysozyme. Accurate
            definition of the antigenic site around the disulphide bridge
            30-115 (site 3) by 'surface-simulation' synthesis
  JOURNAL   Biochem. J. 167 (3), 571-581 (1977)
  MEDLINE   78103135
   PUBMED   603622
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from CD614930.1, BC049849.1,
            CR456526.1, BC011915.2, AK025393.1, M31013.1 and AK025219.1.
            On Aug 17, 2004 this sequence version replaced gi:22507396.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..7474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..7474
                     /gene="MYH9"
                     /note="synonyms: MHA, FTNS, DFNA17, NMMHCA, myosin"
                     /db_xref="GeneID:4627"
                     /db_xref="MIM:160775"
     CDS             185..6067
                     /gene="MYH9"
                     /note="cellular myosin heavy chain, type A; non-muscle
                     myosin heavy polypeptide 9; human non-muscle myosin heavy
                     chain;
                     go_component: myosin [goid 0016459] [evidence IEA];
                     go_component: non-muscle myosin [goid 0005860] [evidence
                     TAS] [pmid 1967836];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: actin binding [goid 0003779] [evidence IEA];
                     go_function: motor activity [goid 0003774] [evidence NR];
                     go_function: motor activity [goid 0003774] [evidence IEA];
                     go_function: calmodulin binding [goid 0005516] [evidence
                     IEA];
                     go_process: perception of sound [goid 0007605] [evidence
                     IEA];
                     go_process: cellular morphogenesis [goid 0000902]
                     [evidence IEA]"
                     /codon_start=1
                     /product="myosin, heavy polypeptide 9, non-muscle"
                     /protein_id="NP_002464.1"
                     /db_xref="GI:12667788"
                     /db_xref="GeneID:4627"
                     /db_xref="MIM:160775"
                     /translation="MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPA
                     SLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLK
                     ERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRS
                     MMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPIL
                     EAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHI
                     FYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEE
                     EQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTP
                     RIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGI
                     LDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDL
                     QPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKA
                     DFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQV
                     AGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGK
                     LDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQAC
                     VLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKA
                     FAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVK
                     VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE
                     EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK
                     LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT
                     DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA
                     LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT
                     ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ
                     LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN
                     EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE
                     NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG
                     CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA
                     CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE
                     LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE
                     DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVA
                     ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA
                     KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR
                     LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE
                     RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK
                     KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL
                     EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKP
                     AE"
     polyA_signal    7071..7076
                     /gene="MYH9"
     polyA_site      7090
                     /gene="MYH9"
                     /evidence=experimental
     polyA_signal    7435..7440
                     /gene="MYH9"
     polyA_site      7455
                     /gene="MYH9"
ORIGIN      
        1 atacgactca ctatagggcg atcaggtgct ggaaagaagg ctaagcaagg ctgacctgct
       61 gcagctcccg cctcgtgcgc tcgccccacc cggccgccgc ccgagcgctc gagaaagtcc
      121 tctcgggaga agcagcgcct gttcccgggg cagatccagg ttcaggtcct ggctataagt
      181 caccatggca cagcaagctg ccgataagta tctctatgtg gataaaaact tcatcaacaa
      241 tccgctggcc caggccgact gggctgccaa gaagctggta tgggtgcctt ccgacaagag
      301 tggctttgag ccagccagcc tcaaggagga ggtgggcgaa gaggccatcg tggagctggt
      361 ggagaatggg aagaaggtga aggtgaacaa ggatgacatc cagaagatga acccgcccaa
      421 gttctccaag gtggaggaca tggcagagct cacgtgcctc aacgaagcct cggtgctgca
      481 caacctcaag gagcgttact actcagggct catctacacc tattcaggcc tgttctgtgt
      541 ggtcatcaat ccttacaaga acctgcccat ctactctgaa gagattgtgg aaatgtacaa
      601 gggcaagaag aggcacgaga tgccccctca catctatgcc atcacagaca ccgcctacag
      661 gagtatgatg caagaccgag aagatcaatc catcttgtgc actggtgaat ctggagctgg
      721 caagacggag aacaccaaga aggtcatcca gtatctggcg tacgtggcgt cctcgcacaa
      781 gagcaagaag gaccagggcg agctggagcg gcagctgctg caggccaacc ccatcctgga
      841 ggccttcggg aacgccaaga ccgtgaagaa tgacaactcc tcccgcttcg gcaaattcat
      901 tcgcatcaac tttgatgtca atggctacat tgttggagcc aacattgaga cttatctttt
      961 ggagaaatct cgtgctatcc gccaagccaa ggaagaacgg accttccaca tcttctatta
     1021 tctcctgtct ggggctggag agcacctgaa gaccgatctc ctgttggagc cgtacaacaa
     1081 ataccgcttc ctgtccaatg gacacgtcac catccccggg cagcaggaca aggacatgtt
     1141 ccaggagacc atggaggcca tgaggattat gggcatccca gaagaggagc aaatgggcct
     1201 gctgcgggtc atctcagggg ttcttcagct cggcaacatc gtcttcaaga aggagcggaa
     1261 cactgaccag gcgtccatgc ccgacaacac agctgcccaa aaggtgtccc atctcttggg
     1321 tatcaatgtg accgatttca ccagaggaat cctcaccccg cgcatcaagg tgggacggga
     1381 ttacgtccag aaggcgcaga ctaaagagca ggctgacttt gccatcgagg ccttggccaa
     1441 ggcgacctat gagcggatgt tccgctggct ggtgctgcgc atcaacaagg ctctggacaa
     1501 gaccaagagg cagggcgcct ccttcatcgg gatcctggac attgccggct tcgagatctt
     1561 tgatctgaac tcgtttgagc agctgtgcat caattacacc aatgagaagc tgcagcagct
     1621 cttcaaccac accatgttca tcctggagca ggaggagtac cagcgcgagg gcatcgagtg
     1681 gaacttcatc gactttggcc tcgacctgca gccctgcatc gacctcattg agaagccagc
     1741 aggccccccg ggcattctgg ccctgctgga cgaggagtgc tggttcccca aagccaccga
     1801 caagagcttc gtggagaagg tgatgcagga gcagggcacc caccccaagt tccagaagcc
     1861 caagcagctg aaggacaaag ctgatttctg cattatccac tatgccggca aggtggatta
     1921 caaagctgac gagtggctga tgaagaacat ggatcccctg aatgacaaca tcgccacact
     1981 gctccaccag tcctctgaca agtttgtctc ggagctgtgg aaggatgtgg accgcatcat
     2041 cggcctggac caggtggccg gcatgtcgga gaccgcactg cccggggcct tcaagacgcg
     2101 gaagggcatg ttccgcactg tggggcagct ttacaaggag cagctggcca agctgatggc
     2161 tacgctgagg aacacgaacc ccaactttgt ccgctgcatc atccccaacc acgagaagaa
     2221 ggccggcaag ctggacccgc atctcgtgct ggaccagctg cgctgcaacg gtgttctcga
     2281 gggcatccgt atctgccgcc agggcttccc caacagggtg gtcttccagg agtttcggca
     2341 gagatatgag atcctgactc caaactccat tcccaagggt ttcatggacg ggaagcaggc
     2401 gtgcgtgctc atgataaaag ccctggagct cgacagcaat ctgtaccgca ttggccagag
     2461 caaagtcttc ttccgtgccg gtgtgctggc ccacctggag gaggagcgag acctgaagat
     2521 caccgacgtc atcatagggt tccaggcctg ctgcaggggc tacctggcca ggaaagcatt
     2581 tgccaagcgg cagcagcagc ttaccgccat gaaggtcctc cagcggaact gcgctgccta
     2641 cctgaagctg cggaactggc agtggtggcg gctcttcacc aaggtcaagc cgctgctgca
     2701 ggtgagccgg caggaggagg agatgatggc caaggaggag gagctggtga aggtcagaga
     2761 gaagcagctg gctgcggaga acaggctcac ggagatggag acgctgcagt ctcagctcat
     2821 ggcagagaaa ttgcagctgc aggagcagct ccaggcagaa accgagctgt gtgccgaggc
     2881 tgaggagctc cgggcccgcc tgaccgccaa gaagcaggaa ttagaagaga tctgccatga
     2941 cctagaggcc agggtggagg aggaggagga gcgctgccag cacctgcagg cggagaagaa
     3001 gaagatgcag cagaacatcc aggagcttga ggagcagctg gaggaggagg agagcgcccg
     3061 gcagaagctg cagctggaga aggtgaccac cgaggcgaag ctgaaaaagc tggaggagga
     3121 gcagatcatc ctggaggacc agaactgcaa gctggccaag gaaaagaaac tgctggaaga
     3181 cagaatagct gagttcacca ccaacctcac agaagaggag gagaaatcta agagcctcgc
     3241 caagctcaag aacaagcatg aggcaatgat cactgacttg gaagagcgcc tccgcaggga
     3301 ggagaagcag cgacaggagc tggagaagac ccgccggaag ctggagggag actccacaga
     3361 cctcagcgac cagatcgccg agctccaggc ccagatcgcg gagctcaaga tgcagctggc
     3421 caagaaagag gaggagctcc aggccgccct ggccagagtg gaagaggaag ctgcccagaa
     3481 gaacatggcc ctcaagaaga tccgggagct ggaatctcag atctctgaac tccaggaaga
     3541 cctggagtct gagcgtgctt ccaggaataa agctgagaag cagaaacggg accttgggga
     3601 agagctagag gcgctgaaaa cagagttgga ggacacgctg gattccacag ctgcccagca
     3661 ggagctcagg tcaaaacgtg agcaggaggt gaacatcctg aagaagaccc tggaggagga
     3721 ggccaagacc cacgaggccc agatccagga gatgaggcag aagcactcac aggccgtgga
     3781 ggagctggcg gagcagctgg agcagacgaa gcgggtgaaa gcaaacctcg agaaggcaaa
     3841 gcagactctg gagaacgagc ggggggagct ggccaacgag gtgaaggtgc tgctgcaggg
     3901 caaaggggac tcggagcaca agcgcaagaa agtggaggcg cagctgcagg agctgcaggt
     3961 caagttcaac gagggagagc gcgtgcgcac agagctggcc gacaaggtca ccaagctgca
     4021 ggtggagctg gacaacgtga ccgggcttct cagccagtcc gacagcaagt ccagcaagct
     4081 caccaaggac ttctccgcgc tggagtccca gctgcaggac actcaggagc tgctgcagga
     4141 ggagaaccgg cagaagctga gcctgagcac caagctcaag caggtggagg acgagaagaa
     4201 ttccttccgg gagcagctgg aggaggagga ggaggccaag cacaacctgg agaagcagat
     4261 cgccaccctc catgcccagg tggccgacat gaaaaagaag atggaggaca gtgtggggtg
     4321 cctggaaact gctgaggagg tgaagaggaa gctccagaag gacctggagg gcctgagcca
     4381 gcggcacgag gagaaggtgg ccgcctacga caagctggag aagaccaaga cgcggctgca
     4441 gcaggagctg gacgacctgc tggtggacct ggaccaccag cgccagagcg cgtgcaacct
     4501 ggagaagaag cagaagaagt ttgaccagct cctggcggag gagaagacca tctctgccaa
     4561 gtatgcagag gagcgcgacc gggctgaggc ggaggcccga gagaaggaga ccaaggctct
     4621 gtcgctggcc cgggccctgg aggaagccat ggagcagaag gcggagctgg agcggctcaa
     4681 caagcagttc cgcacggaga tggaggacct tatgagctcc aaggatgatg tgggcaagag
     4741 tgtccacgag ctggagaagt ccaagcgggc cctagagcag caggtggagg agatgaagac
     4801 gcagctggaa gagctggagg acgagctgca ggccaccgaa gatgccaagc tgcggttgga
     4861 ggtcaacctg caggccatga aggcccagtt cgagcgggac ctgcagggcc gggacgagca
     4921 gagcgaggag aagaagaagc agctggtcag acaggtgcgg gagatggagg cagagctgga
     4981 ggacgagagg aagcagcgct cgatggcagt ggccgcccgg aagaagctgg agatggacct
     5041 gaaggacctg gaggcgcaca tcgactcggc caacaagaac cgggacgaag ccatcaaaca
     5101 gctgcggaag ctgcaggccc agatgaagga ctgcatgcgc gagctggatg acacccgcgc
     5161 ctctcgtgag gagatcctgg cccaggccaa agagaacgag aagaagctga agagcatgga
     5221 ggccgagatg atccagttgc aggaggaact ggcagccgcg gagcgtgcca agcgccaggc
     5281 ccagcaggag cgggatgagc tggctgacga gatcgccaac agcagcggca aaggagccct
     5341 ggcgttagag gagaagcggc gtctggaggc ccgcatcgcc cagctggagg aggagctgga
     5401 ggaggagcag ggcaacacgg agctgatcaa cgaccggctg aagaaggcca acctgcagat
     5461 cgaccagatc aacaccgacc tgaacctgga gcgcagccac gcccagaaga acgagaatgc
     5521 tcggcagcag ctggaacgcc agaacaagga gcttaaggtc aagctgcagg agatggaggg
     5581 cactgtcaag tccaagtaca aggcctccat caccgccctc gaggccaaga ttgcacagct
     5641 ggaggagcag ctggacaacg agaccaagga gcgccaggca gcctgcaaac aggtgcgtcg
     5701 gaccgagaag aagctgaagg atgtgctgct gcaggtggat gacgagcgga ggaacgccga
     5761 gcagtacaag gaccaggccg acaaggcatc tacccgcctg aagcagctca agcggcagct
     5821 ggaggaggcc gaagaggagg cccagcgggc caacgcctcc cgccggaaac tgcagcgcga
     5881 gctggaggac gccactgaga cggccgatgc catgaaccgc gaagtcagct ccctaaagaa
     5941 caagctcagg cgcggggacc tgccgtttgt cgtgccccgc cgaatggccc ggaaaggcgc
     6001 cggggatggc tccgacgaag aggtagatgg caaagcggat ggggctgagg ccaaacctgc
     6061 cgaataagcc tcttctcctg cagcctgaga tggatggaca gacagacacc acagcctccc
     6121 cttcccagac cccgcagcac gcctctcccc accttcttgg gactgctgtg aacatgcctc
     6181 ctcctgccct ccgccccgtc cccccatccc gtttccctcc aggtgttgtt gagggcattt
     6241 ggcttcctct gctgcatccc cttccagctc cctcccctgc tcagaatctg ataccaaaga
     6301 gacagggccc gggcccaggc agagagcgac cagcaggctc ctcagccctc tcttgccaaa
     6361 aagcacaaga tgttgaggcg agcagggcag gcccccgggg aggggccaga gttttctatg
     6421 aatctatttt tcttcagact gaggcctttt ggtagtcgga gcccccgcag tcgtcagcct
     6481 ccctgacgtc tgccaccagc gcccccactc ctcctccttt ctttgctgtt tgcaatcaca
     6541 cgtggtgacc tcacacacct ctgccccttg ggcctcccac tcccatggct ctgggcggtc
     6601 cagaaggagc aggccctggg cctccacctc tgtgcagggc acagaaggct ggggtggggg
     6661 gaggagtgga ttcctcccca ccctgtccca ggcagcgcca ctgtccgctg tctccctcct
     6721 gattctaaaa tgtctcaagt gcaatgcccc ctcccctcct ttaccgagga cagcctgcct
     6781 ctgccacagc aaggctgtcg gggtcaagct ggaaaggcca gcagccttcc agtggcttct
     6841 cccaacactc ttggggacca aatatattta atggttaagg gacttgtccc aagtctgaca
     6901 gccagagcgt tagaggggcc agcggccctc ccaggcgatc ttgtgtctac tctaggactg
     6961 ggcccgaggg tggtttacct gcaccgttga ctcagtatag tttaaaaatc tgccacctgc
     7021 acaggtattt ttgaaagcaa aataaggttt tcttttttcc cctttcttgt aataaatgat
     7081 aaaattccga gtctttctca ctgcctttgt ttagaagaga gtagctcgtc ctcactggtc
     7141 tacactggtt gccgaattta cttgtattcc taactgtttt gtatatgctg cattgagact
     7201 tacggcaaga aggcattttt tttttttaaa ggaaacaaac tctcaaatca tgaagtgata
     7261 taaaagctgc atatgcctac aaagctctga attcaggtcc cagttgctgt cacaaaggag
     7321 tgagtgaaac tcccacccta cccccttttt tatataataa aagtgcctta gcatgtgttg
     7381 cagctgtcac cactacagta agctggttta cagatgtttt ccactgagca tcacaataaa
     7441 gagaaccatg tgctaaaaaa aaaaaaaaaa aaaa
//

LOCUS       NM_002633               2487 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens phosphoglucomutase 1 (PGM1), mRNA.
ACCESSION   NM_002633
VERSION     NM_002633.2  GI:21361620
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Gururaj,A., Barnes,C.J., Vadlamudi,R.K. and Kumar,R.
  TITLE     Regulation of phosphoglucomutase 1 phosphorylation and activity by
            a signaling kinase
  JOURNAL   Oncogene 23 (49), 8118-8127 (2004)
   PUBMED   15378030
  REMARK    GeneRIF: cell signaling kinase Pak1 is a novel regulator of glucose
            metabolism through its phosphorylation and regulation of PGM
            activity.
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Sergeev,A.S., Agapova,R.K., Bogadel'nikova,I.V. and Perel'man,M.I.
  TITLE     The use of discrete characters in discriminant analysis for
            diagnosis of pulmonary tuberculosis and for classification of
            patients differing in treatment efficiency based on polymorphisms
            at nine codominant loci-HP, GC, TF, PI, PGM1, GLO1, C3, ACP1 and
            ESD
  JOURNAL   Genetika 39 (7), 996-1002 (2003)
  MEDLINE   22824292
   PUBMED   12942785
  REMARK    GeneRIF: The analysis involved the data on nine polymorphic
            codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The
            loci were selected by significance of differences in genotype
            frequencies between tuberculosis patients and healthy controls
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Yip,S.P., Lovegrove,J.U., Rana,N.A., Hopkinson,D.A. and
            Whitehouse,D.B.
  TITLE     Mapping recombination hotspots in human phosphoglucomutase (PGM1)
  JOURNAL   Hum. Mol. Genet. 8 (9), 1699-1706 (1999)
  MEDLINE   99371777
   PUBMED   10441333
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Whitehouse,D.B., Putt,W., Lovegrove,J.U., Morrison,K.,
            Hollyoake,M., Fox,M.F., Hopkinson,D.A. and Edwards,Y.H.
  TITLE     Phosphoglucomutase 1: complete human and rabbit mRNA sequences and
            direct mapping of this highly polymorphic marker on human
            chromosome 1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (1), 411-415 (1992)
  MEDLINE   92108065
   PUBMED   1530890
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Douglas,G.R., McAlpine,P.J. and Hamerton,J.L.
  TITLE     Regional localization of loci for human PGM and 6PGD on human
            chromosome one by use of hybrids of Chinese hamster-human somatic
            cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 70 (10), 2737-2740 (1973)
  MEDLINE   74009510
   PUBMED   4517931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC019920.1.
            On Jun 10, 2002 this sequence version replaced gi:4505764.
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31"
     gene            1..2487
                     /gene="PGM1"
                     /db_xref="GeneID:5236"
                     /db_xref="MIM:171900"
     CDS             214..1902
                     /gene="PGM1"
                     /EC_number="5.4.2.2"
                     /note="go_component: cytoplasm [goid 0005737] [evidence
                     NAS] [pmid 1530890];
                     go_function: isomerase activity [goid 0016853] [evidence
                     IEA];
                     go_function: magnesium ion binding [goid 0000287]
                     [evidence IEA];
                     go_function: phosphoglucomutase activity [goid 0004614]
                     [evidence IDA] [pmid 1530890];
                     go_process: glucose metabolism [goid 0006006] [evidence
                     NAS] [pmid 1530890];
                     go_process: carbohydrate metabolism [goid 0005975]
                     [evidence IEA]"
                     /codon_start=1
                     /product="phosphoglucomutase 1"
                     /protein_id="NP_002624.2"
                     /db_xref="GI:21361621"
                     /db_xref="GeneID:5236"
                     /db_xref="MIM:171900"
                     /translation="MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSII
                     STVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCI
                     IRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVC
                     PDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRL
                     KIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETM
                     KSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARS
                     MPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGL
                     WAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMF
                     DRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTG
                     SAGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT"
ORIGIN      
        1 cctttcccct cccgccggac ctgccaggag gtgggctggc gcggagggag ggccctgtcc
       61 cctgtccctt taaggaggag ggccaaacgc cggcctagag tgcggcgtag cccccacccg
      121 ccgtgccctc accccagagc agctgcagcc tcagccggcc gcccctccgc cagccaagtc
      181 cgccgctctg acccccggca gcaagtcgcc accatggtga agatcgtgac agttaagacc
      241 caggcgtacc aggaccagaa gccgggcacg agcgggctgc ggaagcgggt gaaggtgttc
      301 cagagcagcg ccaactacgc ggagaacttc atccagagta tcatctccac cgtggagccg
      361 gcgcagcggc aggaggccac gctggtggtg ggcggggacg gccggttcta catgaaggag
      421 gccatccagc tcatcgctcg catcgctgcc gccaacggga tcggtcgctt ggttatcgga
      481 cagaatggaa tcctctccac ccctgctgta tcctgcatca ttagaaaaat caaagccatt
      541 ggtgggatca ttctgacagc cagtcacaac ccagggggcc ccaatggaga ttttggaatc
      601 aaattcaata tttctaatgg aggtcctgct ccagaagcaa taactgataa aattttccaa
      661 atcagcaaga caattgaaga atatgcagtt tgccctgacc tgaaagtaga ccttggtgtt
      721 ctgggaaagc agcagtttga cttggaaaat aagttcaaac ccttcacagt ggaaattgtg
      781 gattcggtag aagcttatgc tacaatgctg agaagcatct ttgatttcag tgcactgaaa
      841 gaactacttt ctgggccaaa ccgactgaag atccgtattg atgctatgca tggagttgtg
      901 ggaccgtatg taaagaagat cctctgtgaa gaactcggtg cccctgcgaa ctcggcagtt
      961 aactgcgttc ctctggagga ctttggaggc caccaccctg accccaacct cacctatgca
     1021 gctgacctgg tggagaccat gaagtcagga gagcatgatt ttggggctgc ctttgatgga
     1081 gatggggatc gaaacatgat tctgggcaag catgggttct ttgtgaaccc ttcagactct
     1141 gtggctgtca ttgctgccaa catcttcagc attccgtatt tccagcagac tggggtccgc
     1201 ggctttgcac ggagcatgcc cacgagtggt gctctggacc gggtggctag tgctacaaag
     1261 attgctttgt atgagacccc aactggctgg aagttttttg ggaatttgat ggacgcgagc
     1321 aaactgtccc tttgtgggga ggagagcttc gggaccggtt ctgaccacat ccgtgagaaa
     1381 gatggactgt gggctgtcct tgcctggctc tccatcctag ccacccgcaa gcagagtgtg
     1441 gaggacattc tcaaagatca ttggcaaaag tatggccgga atttcttcac caggtatgat
     1501 tacgaggagg tggaagctga gggcgcaaac aaaatgatga aggacttgga ggccctgatg
     1561 tttgatcgct cctttgtggg gaagcagttc tcagcaaatg acaaagttta cactgtggag
     1621 aaggccgata actttgaata cagcgaccca gtggatggaa gcatttcaag aaatcagggc
     1681 ttgcgcctca ttttcacaga tggttctcga atcgtcttcc gactgagcgg cactgggagt
     1741 gccggggcca ccattcggct gtacatcgat agctatgaga aggacgttgc caagattaac
     1801 caggaccccc aggtcatgtt ggcccccctt atttccattg ctctgaaagt gtcccagctg
     1861 caggagagga cgggacgcac tgcacccact gtcatcacct aagaagacag gcctgatgtg
     1921 gtacgtccct ccacccccgg acccatccaa gtcatctgat tgaagagcat gacagaaaca
     1981 aaatgtattc accaagcatt ttaggatttg actttttcac taaccagttg acgagcagtg
     2041 catttacaag gcactgccaa acaagatgcc cttgggagct gtgagggaaa gaggacctgc
     2101 gggcttagat caatctcaat tccttttcat gccctcctgc attgctgctg cgtgggtatt
     2161 tgtctcctta gccatcaggt acagtttaca ctacaatgta agctataggt ggagcatcag
     2221 cagtgagtga ggccattctt catccttagg atgtggcaat gaaatgatgg tgcaagttcc
     2281 tttctctttt gtgaatcttt ccccccattt cctgtttaca tgtaacccaa caaaatgcaa
     2341 tttctagtgc cttctgtcca atcagttctt tcctctgagt gagacgtact tggctacaga
     2401 tttctgcctt gttttgcgac attgtcccat tcacacagat attttgggat aataaaggaa
     2461 aataagctac aaaaaaaaaa aaaaaaa
//

LOCUS       NM_002668                945 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens proteolipid protein 2 (colonic epithelium-enriched)
            (PLP2), mRNA.
ACCESSION   NM_002668
VERSION     NM_002668.1  GI:4505892
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Fisher,S.E., Ciccodicola,A., Tanaka,K., Curci,A., Desicato,S.,
            D'urso,M. and Craig,I.W.
  TITLE     Sequence-based exon prediction around the synaptophysin locus
            reveals a gene-rich area containing novel genes in human proximal
            Xp
  JOURNAL   Genomics 45 (2), 340-347 (1997)
   PUBMED   9344658
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Breitwieser,G.E., McLenithan,J.C., Cortese,J.F., Shields,J.M.,
            Oliva,M.M., Majewski,J.L., Machamer,C.E. and Yang,V.W.
  TITLE     Colonic epithelium-enriched protein A4 is a proteolipid that
            exhibits ion channel characteristics
  JOURNAL   Am. J. Physiol. 272 (3 Pt 1), C957-C965 (1997)
   PUBMED   9124532
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Oliva,M.M., Cortese,J.F. and Yang,V.W.
  TITLE     Promoter regulation of a differentially expressed gene in the human
            colonic epithelial cell lines HT29-18 and HT29-18-C1
  JOURNAL   Gene 159 (2), 151-157 (1995)
   PUBMED   7622043
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Oliva,M.M., Wu,T.C. and Yang,V.W.
  TITLE     Isolation and characterization of a differentiation-dependent gene
            in the human colonic cell line HT29-18
  JOURNAL   Arch. Biochem. Biophys. 302 (1), 183-192 (1993)
   PUBMED   8470895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L09604.1.
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..945
                     /gene="PLP2"
                     /note="synonyms: A4, A4-LSB"
                     /db_xref="GeneID:5355"
                     /db_xref="MIM:300112"
     CDS             76..534
                     /gene="PLP2"
                     /note="A4 differentiation-dependent protein;
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: membrane fraction [goid 0005624] [evidence
                     TAS] [pmid 9124532];
                     go_component: endoplasmic reticulum membrane [goid
                     0005789] [evidence TAS] [pmid 9124532];
                     go_function: ion transporter activity [goid 0015075]
                     [evidence TAS] [pmid 9124532];
                     go_process: ion transport [goid 0006811] [evidence TAS]
                     [pmid 9124532]"
                     /codon_start=1
                     /product="proteolipid protein 2 (colonic
                     epithelium-enriched)"
                     /protein_id="NP_002659.1"
                     /db_xref="GI:4505893"
                     /db_xref="GeneID:5355"
                     /db_xref="MIM:300112"
                     /translation="MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSA
                     STPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVV
                     LVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV"
     polyA_signal    909..914
                     /gene="PLP2"
ORIGIN      
        1 ctgggtgtac agcgtcctcg aaaccacgag caagtgagca gatcctccga ggcaccaggg
       61 actccagccc atgccatggc ggattctgag cgcctctcgg ctcctggctg ctgggccgcc
      121 tgcaccaact tctcgcgcac tcgaaaggga atcctcctgt ttgctgagat tatattatgc
      181 ctggtgatcc tgatctgctt cagtgcctcc acaccaggct actcctccct gtcggtgatt
      241 gagatgatcc ttgctgctat tttctttgtt gtctacatgt gtgacctgca caccaagata
      301 ccattcatca actggccctg gagtgatttc ttccgaaccc tcatagcggc aatcctctac
      361 ctgatcacct ccattgttgt ccttgttgag agaggaaacc actccaaaat cgtcgcaggg
      421 gtactgggcc taatcgctac gtgcctcttt ggctatgacg cctatgtcac cttccccgtt
      481 cggcagccaa gacatacagc agcccccact gaccccgcag atggcccggt gtaggcgaac
      541 ttccctcatt tctctctgca atctgcaaat aactcctcca ttgaaataac tcctccccac
      601 cccaacaaca acattcccag cagaccaact cccaccccct ctttgaggta aaagtgcctt
      661 tattgggaga cttttgtctt ccagcctgcc aatcaaccct cctgggtgtg gccaccatat
      721 gtgtgtgcct aggtcctcct tctgcacgat ccaataggag acaccagttc tgactgaacc
      781 atgcccccac ctaagtcaca aaatgaggga agtggggagt tagatttcag agtccaggcc
      841 ctaggttggg acccactcca aataatctcc tcggtgtggg tggtggttct atagagggat
      901 aaatgaataa taaacattgt taaaatataa aaaaaaaaaa aaaaa
//

LOCUS       NM_002819               3321 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens polypyrimidine tract binding protein 1 (PTBP1),
            transcript variant 1, mRNA.
ACCESSION   NM_002819
VERSION     NM_002819.3  GI:28558994
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Pickering,B.M., Mitchell,S.A., Spriggs,K.A., Stoneley,M. and
            Willis,A.E.
  TITLE     Bag-1 internal ribosome entry segment activity is promoted by
            structural changes mediated by poly(rC) binding protein 1 and
            recruitment of polypyrimidine tract binding protein 1
  JOURNAL   Mol. Cell. Biol. 24 (12), 5595-5605 (2004)
   PUBMED   15169918
  REMARK    GeneRIF: The interactions of PTB-1 and PCBP1 with their cognate
            binding sites on the Bag-1 IRES disrupt many of the RNA-RNA
            interactions, and this creates a largely unstructured region of
            approximately 40 nucleotides that could permit ribosome binding.
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   McCutcheon,I.E., Hentschel,S.J., Fuller,G.N., Jin,W. and Cote,G.J.
  TITLE     Expression of the splicing regulator polypyrimidine tract-binding
            protein in normal and neoplastic brain
  JOURNAL   Neuro-oncology 6 (1), 9-14 (2004)
   PUBMED   14769134
  REMARK    GeneRIF: Strong upregulation of PTB expression in tumor cells of
            glial or primitive neuroectodermal origin suggests involvement of
            this protein in cellular transformation.
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Xie,J., Lee,J.A., Kress,T.L., Mowry,K.L. and Black,D.L.
  TITLE     Protein kinase A phosphorylation modulates transport of the
            polypyrimidine tract-binding protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (15), 8776-8781 (2003)
   PUBMED   12851456
  REMARK    GeneRIF: nucleo-cytoplasmic transport of PTB is regulated by the
            3',5'-cAMP-dependent protein kinase (PKA)
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Mitchell,S.A., Spriggs,K.A., Coldwell,M.J., Jackson,R.J. and
            Willis,A.E.
  TITLE     The Apaf-1 internal ribosome entry segment attains the correct
            structural conformation for function via interactions with PTB and
            unr
  JOURNAL   Mol. Cell 11 (3), 757-771 (2003)
   PUBMED   12667457
  REMARK    GeneRIF: unr and nPTB act as RNA chaperones by changing the
            structure of the IRES into one that permits translation initiation
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Meissner,M., Lopato,S., Gotzmann,J., Sauermann,G. and Barta,A.
  TITLE     Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and
            complexed with splicing factors PTB, SRm160, and SR proteins
  JOURNAL   Exp. Cell Res. 283 (2), 184-195 (2003)
   PUBMED   12581738
  REMARK    GeneRIF: Proto-oncoprotein TLS/FUS is associated to the nuclear
            matrix and complexed with splicing factors PTB, SRm160, and SR
            proteins and plays a role in spliceosome assembly
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Kosinski,P.A., Laughlin,J., Singh,K. and Covey,L.R.
  TITLE     A complex containing polypyrimidine tract-binding protein is
            involved in regulating the stability of CD40 ligand (CD154) mRNA
  JOURNAL   J. Immunol. 170 (2), 979-988 (2003)
   PUBMED   12517964
  REMARK    GeneRIF: PTB has been identified as a component of the putative
            complex involved in regulating the stability of CD154 mRNA at late
            times of T cell activation.
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Hamilton,B.J., Genin,A., Cron,R.Q. and Rigby,W.F.
  TITLE     Delineation of a novel pathway that regulates CD154 (CD40 ligand)
            expression
  JOURNAL   Mol. Cell. Biol. 23 (2), 510-525 (2003)
   PUBMED   12509450
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Simpson,P.J., Davydova,N., Curry,S. and Matthews,S.
  TITLE     Resonance assignment and topology of the 2H, 13C, 15N labelled 29
            kDa N-terminal fragment of the polypyrimidine tract binding protein
            (PTB)
  JOURNAL   J. Biomol. NMR 24 (1), 79-80 (2002)
   PUBMED   12449425
  REMARK    GeneRIF: resonance assignment and topology of the 2H, 13C, 15N
            labelled 29 kDa N-terminal fragment
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Back,S.H., Shin,S. and Jang,S.K.
  TITLE     Polypyrimidine tract-binding proteins are cleaved by caspase-3
            during apoptosis
  JOURNAL   J. Biol. Chem. 277 (30), 27200-27209 (2002)
   PUBMED   12004072
  REMARK    GeneRIF: translation of some IRES-containing mRNAs is regulated by
            proteolytic cleavage of PTB during apoptosis
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Li,B. and Yen,T.S.
  TITLE     Characterization of the nuclear export signal of polypyrimidine
            tract-binding protein
  JOURNAL   J. Biol. Chem. 277 (12), 10306-10314 (2002)
   PUBMED   11781313
  REMARK    GeneRIF: PTB NES is a functionally important domain of this
            multifunctional protein that utilizes an unknown export receptor.
REFERENCE   11 (bases 1 to 3321)
  AUTHORS   Yuan,X., Davydova,N., Conte,M.R., Curry,S. and Matthews,S.
  TITLE     Chemical shift mapping of RNA interactions with the polypyrimidine
            tract binding protein
  JOURNAL   Nucleic Acids Res. 30 (2), 456-462 (2002)
   PUBMED   11788707
  REMARK    GeneRIF: chemical shift mapping of RNA interactions with the
            polypyrimidine tract binding protein
REFERENCE   12 (bases 1 to 3321)
  AUTHORS   Kamath,R.V., Leary,D.J. and Huang,S.
  TITLE     Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein
            is uncoupled from RNA export
  JOURNAL   Mol. Biol. Cell 12 (12), 3808-3820 (2001)
   PUBMED   11739782
  REMARK    GeneRIF: Nucleocytoplasmic shuttling of polypyrimidine
            tract-binding protein is uncoupled from RNA export
REFERENCE   13 (bases 1 to 3321)
  AUTHORS   Romanelli,M.G., Lorenzi,P. and Morandi,C.
  TITLE     Organization of the human gene encoding heterogeneous nuclear
            ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I
            related pseudogene
  JOURNAL   Gene 255 (2), 267-272 (2000)
   PUBMED   11024286
REFERENCE   14 (bases 1 to 3321)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Identification of a group of cellular cofactors that stimulate the
            binding of RNA polymerase II and TRP-185 to human immunodeficiency
            virus 1 TAR RNA
  JOURNAL   J. Biol. Chem. 271 (8), 4201-4208 (1996)
   PUBMED   8626763
REFERENCE   15 (bases 1 to 3321)
  AUTHORS   Black,A.C., Luo,J., Chun,S., Bakker,A., Fraser,J.K. and
            Rosenblatt,J.D.
  TITLE     Specific binding of polypyrimidine tract binding protein and hnRNP
            A1 to HIV-1 CRS elements
  JOURNAL   Virus Genes 12 (3), 275-285 (1996)
   PUBMED   8883365
REFERENCE   16 (bases 1 to 3321)
  AUTHORS   Raimondi,E., Romanelli,M.G., Moralli,D., Gamberi,C., Russo,M.P. and
            Morandi,C.
  TITLE     Assignment of the human gene encoding heterogeneous nuclear RNA
            ribonucleoprotein I (PTB) to chromosome 14q23-q24.1
  JOURNAL   Genomics 27 (3), 553-555 (1995)
   PUBMED   7558043
REFERENCE   17 (bases 1 to 3321)
  AUTHORS   Ghetti,A., Pinol-Roma,S., Michael,W.M., Morandi,C. and Dreyfuss,G.
  TITLE     hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear
            localization and association with hnRNAs
  JOURNAL   Nucleic Acids Res. 20 (14), 3671-3678 (1992)
   PUBMED   1641332
REFERENCE   18 (bases 1 to 3321)
  AUTHORS   Patton,J.G., Mayer,S.A., Tempst,P. and Nadal-Ginard,B.
  TITLE     Characterization and molecular cloning of polypyrimidine
            tract-binding protein: a component of a complex necessary for
            pre-mRNA splicing
  JOURNAL   Genes Dev. 5 (7), 1237-1251 (1991)
   PUBMED   1906036
REFERENCE   19 (bases 1 to 3321)
  AUTHORS   Gil,A., Sharp,P.A., Jamison,S.F. and Garcia-Blanco,M.A.
  TITLE     Characterization of cDNAs encoding the polypyrimidine tract-binding
            protein
  JOURNAL   Genes Dev. 5 (7), 1224-1236 (1991)
   PUBMED   1906035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002397.2 and X66975.1.
            On Feb 25, 2003 this sequence version replaced gi:14165462.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA-binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has four
            repeats of quasi-RNA recognition motif (RRM) domains that bind
            RNAs. This protein binds to the intronic polypyrimidine tracts that
            requires pre-mRNA splicing and acts via the protein degradation
            ubiquitin-proteasome pathway. It may also promote the binding of U2
            snRNP to pre-mRNAs. This protein is localized in the nucleoplasm
            and it is also detected in the perinucleolar structure.
            Alternatively spliced transcript variants encoding different
            isoforms have been described.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3321
                     /gene="PTBP1"
                     /note="synonyms: PTB, PTB2, PTB3, PTB4, pPTB, HNRPI,
                     PTB-1, PTB-T, HNRNPI, MGC8461, MGC10830"
                     /db_xref="GeneID:5725"
                     /db_xref="MIM:600693"
     CDS             88..1761
                     /gene="PTBP1"
                     /note="isoform a is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein polypeptide I;
                     RNA-binding protein; polypyrimidine tract binding protein
                     (heterogeneous nuclear ribonucleoprotein I);
                     go_component: nucleolus [goid 0005730] [evidence TAS]
                     [pmid 1641332];
                     go_component: nucleoplasm [goid 0005654] [evidence TAS]
                     [pmid 1641332];
                     go_component: heterogeneous nuclear ribonucleoprotein
                     complex [goid 0030530] [evidence TAS] [pmid 1641332];
                     go_function: poly-pyrimidine tract binding [goid 0008187]
                     [evidence TAS] [pmid 1906036];
                     go_process: RNA splicing [goid 0008380] [evidence TAS]
                     [pmid 1906036];
                     go_process: nuclear mRNA splicing, via spliceosome [goid
                     0000398] [evidence IEA]"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 1 isoform
                     a"
                     /protein_id="NP_002810.1"
                     /db_xref="GI:4506243"
                     /db_xref="GeneID:5725"
                     /db_xref="MIM:600693"
                     /translation="MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDS
                     KKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMN
                     TEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSG
                     NLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTK
                     NNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYT
                     RPDLPSGDSQPSLDQTMAAAFGAPGIISASPYAGAGFPPTFAIPQAAGLSVPNVHGAL
                     APLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQR
                     VKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQEDQ
                     GLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVVK
                     GFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVSFSKSTI"
     misc_feature    980..1057
                     /gene="PTBP1"
                     /note="Region: missing 78 bases in variant 3"
     misc_feature    980..1000
                     /gene="PTBP1"
                     /note="Region: missing 21 bases in variant 2"
     polyA_signal    3135..3140
                     /gene="PTBP1"
     polyA_site      3157
                     /gene="PTBP1"
     polyA_signal    3228..3233
                     /gene="PTBP1"
     polyA_site      3247
                     /gene="PTBP1"
     polyA_site      3262
                     /gene="PTBP1"
                     /evidence=experimental
ORIGIN      
        1 ttgtgagtct ataactcgga gccgttgggt cggttcctgc tattccggcg cctccactcc
       61 gtcccccgcg ggtctgctct gtgtgccatg gacggcattg tcccagatat agccgttggt
      121 acaaagcggg gatctgacga gcttttctct acttgtgtca ctaacggacc gtttatcatg
      181 agcagcaact cggcttctgc agcaaacgga aatgacagca agaagttcaa aggtgacagc
      241 cgaagtgcag gcgtcccctc tagagtgatc cacatccgga agctccccat cgacgtcacg
      301 gagggggaag tcatctccct ggggctgccc tttgggaagg tcaccaacct cctgatgctg
      361 aaggggaaaa accaggcctt catcgagatg aacacggagg aggctgccaa caccatggtg
      421 aactactaca cctcggtgac ccctgtgctg cgcggccagc ccatctacat ccagttctcc
      481 aaccacaagg agctgaagac cgacagctct cccaaccagg cgcgggccca ggcggccctg
      541 caggcggtga actcggtcca gtcggggaac ctggccttgg ctgcctcggc ggcggccgtg
      601 gacgcaggga tggcgatggc cgggcagagc cccgtgctca ggatcatcgt ggagaacctc
      661 ttctaccctg tgaccctgga tgtgctgcac cagattttct ccaagttcgg cacagtgttg
      721 aagatcatca ccttcaccaa gaacaaccag ttccaggccc tgctgcagta tgcggacccc
      781 gtgagcgccc agcacgccaa gctgtcgctg gacgggcaga acatctacaa cgcctgctgc
      841 acgctgcgca tcgacttttc caagctcacc agcctcaacg tcaagtacaa caatgacaag
      901 agccgtgact acacacgccc agacctgcct tccggggaca gccagccctc gctggaccag
      961 accatggccg cggccttcgg tgcacctggt ataatctcag cctctccgta tgcaggagct
     1021 ggtttccctc ccacctttgc cattcctcaa gctgcaggcc tttccgttcc gaacgtccac
     1081 ggcgccctgg cccccctggc catcccctcg gcggcggcgg cagctgcggc ggcaggtcgg
     1141 atcgccatcc cgggcctggc gggggcagga aattctgtat tgctggtcag caacctcaac
     1201 ccagagagag tcacacccca aagcctcttt attcttttcg gcgtctacgg tgacgtgcag
     1261 cgcgtgaaga tcctgttcaa taagaaggag aacgccctag tgcagatggc ggacggcaac
     1321 caggcccagc tggccatgag ccacctgaac gggcacaagc tgcacgggaa gcccatccgc
     1381 atcacgctct cgaagcacca gaacgtgcag ctgccccgcg agggccagga ggaccagggc
     1441 ctgaccaagg actacggcaa ctcacccctg caccgcttca agaagccggg ctccaagaac
     1501 ttccagaaca tattcccgcc ctcggccacg ctgcacctct ccaacatccc gccctcagtc
     1561 tccgaggagg atctcaaggt cctgttttcc agcaatgggg gcgtcgtcaa aggattcaag
     1621 ttcttccaga aggaccgcaa gatggcactg atccagatgg gctccgtgga ggaggcggtc
     1681 caggccctca ttgacctgca caaccacgac ctcggggaga accaccacct gcgggtctcc
     1741 ttctccaagt ccaccatcta ggggcacagg cccccacggc cgggccccct ggcgacaact
     1801 tccatcattc cagagaaaag ccactttaaa aacagctgaa gtgaccttag cagaccagag
     1861 attttatttt tttaaagaga aatcagttta cctgttttta aaaaaattaa atctagttca
     1921 ccttgctcac cctgcggtga cagggacagc tcaggctctt ggtgactgtg gcagcgggag
     1981 ttcccggccc tccacacccg gggccagacc ctcggggcca tgccttggtg gggcctgtgt
     2041 cgggcgtggg gcctgcaggt gggcgccccg accacgactt ggcttccttg tgccttaaaa
     2101 aacctgcctt cctgcagcca cacacccacc cggggtgtcc tggggaccca aggggtgggg
     2161 gggtcacacc agagagaggc agggggcctg gccggctcct gcaggatcat gcagctgggg
     2221 cgcggcggcc gcggctgcga caccccaacc ccagccctct aatcaagtca cgtgattctc
     2281 ccttcacccc gcccccaggg ccttcccttc tgcccccagg cgggctcccc gctgctccag
     2341 ctgcggagct ggtcgacata atctctgtat tatatacttt gcagttgcag acgtctgtgc
     2401 ctagcaatat ttccagttga ccaaatattc taatcttttt tcatttatat gcaaaagaaa
     2461 tagttttaag taacttttta tagcaagatg atacaatggt atgagtgtaa tctaaacttc
     2521 cttgtggtat taccttgtat gctgttactt ttattttatt ccttgtaatt aagtcacagg
     2581 caggacccag tttccagaga gcaggcgggg ccgcccagtg ggtcaggcac agggagcccc
     2641 ggtcctatct tagagcccct gagcttcagg gaaggggcgg gcgtgtcgcc gcctctggca
     2701 tcgcctccgg ttgccttaca ccacgccttc acctgcagtc gcctagaaaa cttgctctca
     2761 aacttcaggg ttttttcttc cttcaaattt tggaccaaag tctcatttct gtgttttgcc
     2821 tgcctctgat gctgggaccc ggaaggcggg cgctcctcct gtcttctctg tgctctttct
     2881 accgcccccg cgtcctgtcc cgggggctct cctaggatcc cctttccgta aaagcgtgta
     2941 acaagggtgt aaatatttat aattttttat acctgttgtg agacccgagg ggcggcggcg
     3001 cggtttttta tggtgacaca aatgtatatt ttgctaacag caattccagg ctcagtattg
     3061 tgaccgcgga gccacagggg accccacgca cattccgttg ccttacccga tggcttgtga
     3121 cgcggagaga accgattaaa accgtttgag aaactcctcc cttgtctagc cctgtgttcg
     3181 ctgtggacgc tgtagaggca ggttggccag tctgtacctg gacttcgaat aaatcttctg
     3241 tatcctcgct ccgttccgcc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaaaaaaaaa aaaaaaaaaa a
//

LOCUS       NM_002835               3161 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens protein tyrosine phosphatase, non-receptor type 12
            (PTPN12), mRNA.
ACCESSION   NM_002835
VERSION     NM_002835.2  GI:18375651
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3161)
  AUTHORS   Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D.
  TITLE     Inhibition of the catalytic activity of cell adhesion kinase beta
            by protein-tyrosine phosphatase-PEST-mediated dephosphorylation
  JOURNAL   J. Biol. Chem. 276 (26), 24422-24431 (2001)
   PUBMED   11337490
REFERENCE   2  (bases 1 to 3161)
  AUTHORS   Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A.
            and Goff,S.P.
  TITLE     Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine
            phosphatase to the c-Abl kinase to mediate Abl dephosphorylation
  JOURNAL   Mol. Cell 6 (6), 1413-1423 (2000)
   PUBMED   11163214
REFERENCE   3  (bases 1 to 3161)
  AUTHORS   Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R.,
            Griffin,J.D. and Schaller,M.D.
  TITLE     The noncatalytic domain of protein-tyrosine phosphatase-PEST
            targets paxillin for dephosphorylation in vivo
  JOURNAL   J. Biol. Chem. 275 (2), 1405-1413 (2000)
   PUBMED   10625692
REFERENCE   4  (bases 1 to 3161)
  AUTHORS   Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and
            Nose,K.
  TITLE     Hic-5, a paxillin homologue, binds to the protein-tyrosine
            phosphatase PEST (PTP-PEST) through its LIM 3 domain
  JOURNAL   J. Biol. Chem. 274 (14), 9847-9853 (1999)
   PUBMED   10092676
REFERENCE   5  (bases 1 to 3161)
  AUTHORS   Garton,A.J. and Tonks,N.K.
  TITLE     Regulation of fibroblast motility by the protein tyrosine
            phosphatase PTP-PEST
  JOURNAL   J. Biol. Chem. 274 (6), 3811-3818 (1999)
   PUBMED   9920935
REFERENCE   6  (bases 1 to 3161)
  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J.,
            Imai,K. and Yachi,A.
  TITLE     Chromosomal localization of the protein tyrosine phosphatase G1
            gene and characterization of the aberrant transcripts in human
            colon cancer cells
  JOURNAL   FEBS Lett. 339 (3), 222-228 (1994)
   PUBMED   7509295
REFERENCE   7  (bases 1 to 3161)
  AUTHORS   Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K.
  TITLE     Cloning and expression of PTP-PEST. A novel, human,
            nontransmembrane protein tyrosine phosphatase
  JOURNAL   J. Biol. Chem. 268 (9), 6622-6628 (1993)
   PUBMED   8454633
REFERENCE   8  (bases 1 to 3161)
  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M.,
            Adachi,M., Imai,K. and Yachi,A.
  TITLE     Cloning and characterization of a human cDNA encoding a novel
            putative cytoplasmic protein-tyrosine-phosphatase
  JOURNAL   Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992)
   PUBMED   1472029
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M93425.1.
            On Jan 25, 2002 this sequence version replaced gi:4506286.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains a C-terminal PEST
            motif, which serves as a protein-protein interaction domain, and
            may be related to protein intracellular half-life. This PTP was
            found to bind and dephosphorylate the product of oncogene c-ABL,
            thus may play a role in oncogenesis. This PTP was shown to interact
            with, and dephosphorylate, various of cytoskeleton and cell
            adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and
            paxillin, which suggested its regulatory roles in controlling cell
            shape and mobility.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3161
                     /gene="PTPN12"
                     /note="synonyms: PTPG1, PTP-PEST"
                     /db_xref="GeneID:5782"
                     /db_xref="MIM:600079"
     CDS             30..2372
                     /gene="PTPN12"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase G1;
                     go_component: cytoplasm [goid 0005737] [evidence TAS]
                     [pmid 1472029];
                     go_component: soluble fraction [goid 0005625] [evidence
                     TAS] [pmid 1472029];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: non-membrane spanning protein tyrosine
                     phosphatase activity [goid 0004726] [evidence TAS] [pmid
                     8454633];
                     go_process: protein amino acid dephosphorylation [goid
                     0006470] [evidence TAS] [pmid 8454633]"
                     /codon_start=1
                     /product="protein tyrosine phosphatase, non-receptor type
                     12"
                     /protein_id="NP_002826.2"
                     /db_xref="GI:18375652"
                     /db_xref="GeneID:5782"
                     /db_xref="MIM:600079"
                     /translation="MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRT
                     EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKA
                     YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPF
                     KISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
                     YQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSA
                     VQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMISSIEPEKQDSPP
                     PKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPV
                     LHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
                     DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSV
                     TPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTV
                     SLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNI
                     STASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTP
                     ESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECP
                     PTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT"
     polyA_signal    3134..3139
                     /gene="PTPN12"
     polyA_site      3161
                     /gene="PTPN12"
ORIGIN      
        1 agcgaccgca gccgggggga cgcgggagga tggagcaagt ggagatcctg aggaaattca
       61 tccagagggt ccaggccatg aagagtcctg accacaatgg ggaggacaac ttcgcccggg
      121 acttcatgcg gttaagaaga ttgtctacca aatatagaac agaaaagata tatcccacag
      181 ccactggaga aaaagaagaa aatgttaaaa agaacagata caaggacata ctgccatttg
      241 atcacagccg agttaaattg acattaaaga ctccttcaca agattcagac tatatcaatg
      301 caaattttat aaagggcgtc tatgggccaa aagcatatgt agcaactcaa ggacctttag
      361 caaatacagt aatagatttt tggaggatga tatgggagta taatgttgtg atcattgtaa
      421 tggcctgccg agaatttgag atgggaagga aaaaatgtga gcgctattgg cctttgtatg
      481 gagaagaccc cataacgttt gcaccattta aaatttcttg tgaggatgaa caagcaagaa
      541 cagactactt catcaggaca ctcttacttg aatttcaaaa tgaatctcgt aggctgtatc
      601 agtttcatta tgtgaactgg ccagaccatg atgttccttc atcatttgat tctattctgg
      661 acatgataag cttaatgagg aaatatcaag aacatgaaga tgttcctatt tgtattcatt
      721 gcagtgcagg ctgtggaaga acaggtgcca tttgtgccat agattatacg tggaatttac
      781 taaaagctgg gaaaatacca gaggaattta atgtatttaa tttaatacaa gaaatgagaa
      841 cacaaaggca ttctgcagta caaacaaagg agcaatatga acttgttcat agagctattg
      901 cccaactgtt tgaaaaacag ctacaactat atgaaattca tggagctcag aaaattgctg
      961 atggagtgaa tgaaattaac actgaaaaca tgatcagctc catagagcct gaaaaacaag
     1021 attctcctcc tccaaaacca ccaaggaccc gcagttgcct tgttgaaggg gatgctaaag
     1081 aagaaatact gcagccaccg gaacctcatc cagtgccacc catcttgaca ccttctcccc
     1141 cttcagcttt tccaacagtc actactgtgt ggcaggacaa tgatagatac catccaaagc
     1201 cagtgttgca tatggtttca tcagaacaac attcagcaga cctcaacaga aactatagta
     1261 aatcaacaga acttccaggg aaaaatgaat caacaattga acagatagat aaaaaattgg
     1321 aacgaaattt aagttttgag attaagaagg tccctctcca agagggacca aaaagttttg
     1381 atgggaacac acttttgaat aggggacatg caattaaaat taaatctgct tcaccttgta
     1441 tagctgataa aatctctaag ccacaggaat taagttcaga tctaaatgtc ggtgatactt
     1501 cccagaattc ttgtgtggac tgcagtgtaa cacaatcaaa caaagtttca gttactccac
     1561 cagaagaatc ccagaattca gacacacctc caaggccaga ccgcttgcct cttgatgaga
     1621 aaggacatgt aacgtggtca tttcatggac ctgaaaatgc catacccata cctgatttat
     1681 ctgaaggcaa ttcctcagat atcaactatc aaactaggaa aactgtgagt ttaacaccaa
     1741 gtcctacaac acaagttgaa acacctgatc ttgtggatca tgataacact tcaccactct
     1801 tcagaacacc cctcagtttt actaatccac ttcactctga tgactcagac tcagatgaaa
     1861 gaaactctga tggtgctgtg acccagaata aaactaatat ttcaacagca agtgccacag
     1921 tttctgctgc cactagtact gaaagcattt ctactaggaa agtattgcca atgtccattg
     1981 ctagacataa tatagcagga acaacacatt caggtgctga aaaagatgtt gatgttagtg
     2041 aagattcacc tcctccccta cctgaaagaa ctcctgaatc gtttgtgtta gcaagtgaac
     2101 ataatacacc tgtaagatcg gaatggagtg aacttcaaag tcaggaacga tctgaacaaa
     2161 aaaagtctga aggcttgata acctctgaaa atgagaaatg tgatcatcca gcgggaggta
     2221 ttcactatga aatgtgcata gaatgtccac ctactttcag tgacaagaga gaacaaatat
     2281 cagaaaatcc aacagaagcc acagatattg gttttggtaa tcgatgtgga aaacccaaag
     2341 gaccaagaga tccaccttca gaatggacat gattcaggga gctagaagac actttaagtt
     2401 atactggaaa attcaggtgc cactgaaagc cagatttata gtattccatc tttaatatgt
     2461 gggactaaca gcagtgtaga ttgttacctt aatatttttt gctgggacca tctacctgcc
     2521 ttatactaca cttaggaaaa agtattacat atggtttatt ttgaaacttc aagtattatt
     2581 gccttaatgt ctcttaaccc tgttacacgc tgcttgtaga catgttaata tagtaatacc
     2641 tttatgatat attgagttta aggactactc tttttctgtt ttatcatgta tgcattattt
     2701 tgtatatgta cagggcaagt aggtatataa tttgataaag ttgcaattga aatattatta
     2761 acagaagatg taagaaattt ctgcatggtc taaatctttg tgtactttat ttgtaaatta
     2821 tttgccctgg agttttagaa aatagtttct gaattttaaa cttgctggat tcatgcagcc
     2881 agctttgcag gttatcagag atcaaagatt gtaataataa ttttgtaaat tgtaagcaaa
     2941 aagttatttt tatattatat acagtctaat tgttcatcct aattgttcct gttttcatct
     3001 agtcagagat tcagtaagtg ccttggaaca atattgaatt ctcttagctt gtgtgtgttt
     3061 ctttaatatt tgaactcaag tgggattaga agactatcaa aatacatgta tgtttcagga
     3121 tatttgacct gtcattaaaa aaaacaaaca gttttacagt g
//

LOCUS       NM_002958               2951 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens RYK receptor-like tyrosine kinase (RYK), transcript
            variant 2, mRNA.
ACCESSION   NM_002958
VERSION     NM_002958.2  GI:54607017
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2951)
  AUTHORS   Trivier,E. and Ganesan,T.S.
  TITLE     RYK, a catalytically inactive receptor tyrosine kinase, associates
            with EphB2 and EphB3 but does not interact with AF-6
  JOURNAL   J. Biol. Chem. 277 (25), 23037-23043 (2002)
   PUBMED   11956217
  REMARK    GeneRIF: RYK, a catalytically inactive receptor tyrosine kinase,
            associates with EphB2 and EphB3 but does not interact with AF-6.
REFERENCE   2  (bases 1 to 2951)
  AUTHORS   Katso,R.M., Russell,R.B. and Ganesan,T.S.
  TITLE     Functional analysis of H-Ryk, an atypical member of the receptor
            tyrosine kinase family
  JOURNAL   Mol. Cell. Biol. 19 (9), 6427-6440 (1999)
   PUBMED   10454588
REFERENCE   3  (bases 1 to 2951)
  AUTHORS   Wang,X.C., Katso,R., Butler,R., Hanby,A.M., Poulsom,R., Jones,T.,
            Sheer,D. and Ganesan,T.S.
  TITLE     H-RYK, an unusual receptor kinase: isolation and analysis of
            expression in ovarian cancer
  JOURNAL   Mol. Med. 2 (2), 189-203 (1996)
   PUBMED   8726462
REFERENCE   4  (bases 1 to 2951)
  AUTHORS   Tamagnone,L., Partanen,J., Armstrong,E., Lasota,J., Ohgami,K.,
            Tazunoki,T., LaForgia,S., Huebner,K. and Alitalo,K.
  TITLE     The human ryk cDNA sequence predicts a protein containing two
            putative transmembrane segments and a tyrosine kinase catalytic
            domain
  JOURNAL   Oncogene 8 (7), 2009-2014 (1993)
   PUBMED   8390040
REFERENCE   5  (bases 1 to 2951)
  AUTHORS   Stacker,S.A., Hovens,C.M., Vitali,A., Pritchard,M.A., Baker,E.,
            Sutherland,G.R. and Wilks,A.F.
  TITLE     Molecular cloning and chromosomal localisation of the human
            homologue of a receptor related to tyrosine kinases (RYK)
  JOURNAL   Oncogene 8 (5), 1347-1356 (1993)
   PUBMED   8386829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X69970.1, CN309980.1,
            BC021700.2 and BQ003586.1.
            On Oct 23, 2004 this sequence version replaced gi:11863158.
            
            Summary: The protein encoded by this gene is an atypical member of
            the family of growth factor receptor protein tyrosine kinases,
            differing from other members at a number of conserved residues in
            the activation and nucleotide binding domains. This gene product
            belongs to a subfamily whose members do not appear to be regulated
            by phosphorylation in the activation segment. It has been suggested
            that mediation of biological activity by recruitment of a
            signaling-competent auxiliary protein may occur through an as yet
            uncharacterized mechanism. Two alternative splice variants have
            been identified, encoding distinct isoforms.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1, resulting
            in a shorter protein (isoform 2).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22"
     gene            1..2951
                     /gene="RYK"
                     /note="synonyms: RYK1, D3S3195"
                     /db_xref="GeneID:6259"
                     /db_xref="MIM:600524"
     CDS             91..1914
                     /gene="RYK"
                     /EC_number="2.7.1.112"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hydroxyaryl-protein kinase;
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 8386829];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: receptor activity [goid 0004872] [evidence
                     IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: transmembrane receptor protein tyrosine
                     kinase activity [goid 0004714] [evidence TAS] [pmid
                     8386829];
                     go_process: signal transduction [goid 0007165] [evidence
                     TAS] [pmid 8386829];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence NAS] [pmid 8726462]"
                     /codon_start=1
                     /product="RYK receptor-like tyrosine kinase isoform 2"
                     /protein_id="NP_002949.2"
                     /db_xref="GI:54607018"
                     /db_xref="GeneID:6259"
                     /db_xref="MIM:600524"
                     /translation="MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGA
                     AAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLV
                     PSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCT
                     GKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPV
                     HAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQP
                     STQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKD
                     VLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRN
                     LLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIA
                     CGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRW
                     MALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPIN
                     CPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV"
     polyA_signal    2912..2917
                     /gene="RYK"
     polyA_site      2934
                     /gene="RYK"
ORIGIN      
        1 cggctcgggg ctgtgagcgg ctcggggccg ggggtgggcg gcggtgcggc gggcggccga
       61 cgctcctctt cggcggcggc ggcggcggcc atgcgtgggg cggcgcggct ggggcggccg
      121 ggccggagtt gcctcccggg ggcccgcggc ctgagggccc cgccgccgcc gccgctgctg
      181 cttctgcttg cgctgttgcc gctgctgccc gcgcctggcg ctgccgccgc ccccgccccg
      241 cggcccccgg agctgcagtc ggcttccgcg gggcccagcg tgagtctcta cctgagcgag
      301 gacgaggtgc gccggctgat cggtcttgat gcagaacttt attatgtgag aaatgacctt
      361 attagtcact acgctctatc ctttagtctg ttagtaccca gtgagacaaa tttcctgcac
      421 ttcacctggc atgcgaagtc caaggttgaa tataagctgg gattccaagt ggacaatgtt
      481 ttggcaatgg atatgcccca ggtcaacatt tctgttcagg gggaagttcc acgcacttta
      541 tcagtgtttc gggtagagct ttcctgtact ggcaaagtag attctgaagt tatgatacta
      601 atgcagctca acttgacagt aaattcttca aaaaatttta ccgtcttaaa ttttaaacga
      661 aggaaaatgt gctacaaaaa acttgaagaa gtaaaaactt cagccttgga caaaaacact
      721 agcagaacta tttatgatcc tgtacatgca gctccaacca cttctacgcg tgtgttttat
      781 attagtgtag gggtttgttg tgcagtaata tttctcgtag caataatatt agctgttttg
      841 caccttcata gtatgaaaag gattgaactg gatgacagca ttagtgccag cagtagttcc
      901 caagggctgt ctcagccatc cacccagacg actcagtatc tgagagcaga cacgcccaac
      961 aatgcaactc ctatcaccag ttatcctacc ttgcggatag agaagaacga cttgagaagt
     1021 gtcactcttt tggaggccaa aggcaaggtg aaggatatag caatatccag agagaggata
     1081 actctaaaag atgtactcca agaaggtact tttgggcgta ttttccatgg gattttaata
     1141 gatgaaaaag atccaaataa agaaaaacaa gcatttgtca aaacagttaa agatcaagct
     1201 tctgaaattc aggtgacaat gatgctcact gaaagttgta agctgcgagg tcttcatcac
     1261 agaaatcttc ttcctattac tcatgtgtgt atagaagaag gagaaaagcc catggtgata
     1321 ttgccttaca tgaattgggg gaatcttaaa ttgtttttac gacagtgcaa gttagtagag
     1381 gccaataatc cacaggcaat ttctcagcaa gacctggtac acatggctat tcagattgcc
     1441 tgtggaatga gctacctggc cagaagggaa gtcatccaca aagacctggc tgccaggaac
     1501 tgtgtcattg atgacacact tcaagttaag atcacagaca atgccctctc cagagacttg
     1561 ttccccatgg actatcactg tctgggggac aatgaaaaca ggccagttcg ttggatggct
     1621 cttgaaagtc tggttaataa cgagttctct agcgctagtg atgtgtgggc ctttggagtg
     1681 acgctgtggg aactcatgac tctgggccag actccctacg tggacattga ccccttcgag
     1741 atggccgcat acctgaaaga tggttaccga atagcccagc caatcaactg tcctgatgaa
     1801 ttatttgctg tgatggcctg ttgctgggcc ttagatccag aggagaggcc caagtttcag
     1861 cagctggtac agtgcctaac agagtttcat gcagccctgg gggcctacgt ctgactcctc
     1921 tccaatccca caccatcagg aagaaggtgc ctgtcggggc tcacttgaag cctgtcaggg
     1981 atgctttgta tctaacacaa cgccaacaga agcacatttg tcttccagaa caccgtgcct
     2041 tagaaatgct ttagaatctg aactttttaa gacagactta ataatgtggc atattttcta
     2101 gatatcactt ttattaggtt gaactgaaag ggtttttgta aattttttgg ccaaaatttt
     2161 ttaaaacata cttactttgg actaggggta cattcttaca aaataaataa acagttttta
     2221 aaattgttta gacacagata tttggaatta gctatcttag tgccaactgc tttttatttt
     2281 tttacttcat caaggtgatg taagtgactc acctttaaag tttttttagt gttatttttt
     2341 atcactactc tgggaaatgg tttgtcttca agatgcaata cttttcttag taaaggaaaa
     2401 acagcataaa aagatacctg gtctgccttg tacaagaaaa ggcaatatta gaggaagaaa
     2461 atttaaagaa aagctagagg aaaaaaaaat tttttaaaaa atacttatta gaagcaaact
     2521 gcccttgcat ggaaaactgt ttattttttt cagtgaaaag gaattctgct ttcgtgtttt
     2581 tgggaaagca ggaactgagt tcattacatc tttaatttgg cagaaattag cctttctgtg
     2641 aaccagatgt ggtttggggc agatctgtag taaacaatgg tgattttatt tatttttact
     2701 ctctggaaaa ggagataata caattccaga aagtgaactc atatttctaa ggttaagatt
     2761 cccttttatt gcacctagaa tagtgctatg cacagagcgg gtgcttgagt tgttgtcgtt
     2821 ttttgtttgt tttttaaatg taaactggta aattttgtgc ttatcttcaa ggctggctta
     2881 agtataaaat tgttttttaa acacttgaaa aattaaagga tttgttttat attaaaaaaa
     2941 aaaaaaaaaa a
//

LOCUS       NM_003051               3410 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens solute carrier family 16 (monocarboxylic acid
            transporters), member 1 (SLC16A1), mRNA.
ACCESSION   NM_003051
VERSION     NM_003051.2  GI:19923752
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3410)
  AUTHORS   Daberkow,R.L., White,B.R., Cederberg,R.A., Griffin,J.B. and
            Zempleni,J.
  TITLE     Monocarboxylate transporter 1 mediates biotin uptake in human
            peripheral blood mononuclear cells
  JOURNAL   J. Nutr. 133 (9), 2703-2706 (2003)
   PUBMED   12949353
  REMARK    GeneRIF: MCT mediates biotin uptake in human lymphoid cells.
REFERENCE   2  (bases 1 to 3410)
  AUTHORS   Asada,K., Miyamoto,K., Fukutomi,T., Tsuda,H., Yagi,Y., Wakazono,K.,
            Oishi,S., Fukui,H., Sugimura,T. and Ushijima,T.
  TITLE     Reduced expression of GNA11 and silencing of MCT1 in human breast
            cancers
  JOURNAL   Oncology 64 (4), 380-388 (2003)
   PUBMED   12759536
  REMARK    GeneRIF: MCT1 is involved in cellular transportation of butyrate,
            which induces cellular differentiation. Down-regulation is
            suggested to be involved in human breast cancers.
REFERENCE   3  (bases 1 to 3410)
  AUTHORS   Zhang,G.Z., Huang,G.J., Li,W.L., Wu,G.M. and Qian,G.S.
  TITLE     Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation
            and growth of human lung adenocarcinoma cells
  JOURNAL   Ai Zheng 21 (7), 719-723 (2002)
   PUBMED   12479094
  REMARK    GeneRIF: MCT1 and NHE1 genes play important regulation roles in
            proliferation and growth of tumor cells, probably by affecting pHi.
REFERENCE   4  (bases 1 to 3410)
  AUTHORS   Lambert,D.W., Wood,I.S., Ellis,A. and Shirazi-Beechey,S.P.
  TITLE     Molecular changes in the expression of human colonic nutrient
            transporters during the transition from normality to malignancy
  JOURNAL   Br. J. Cancer 86 (8), 1262-1269 (2002)
   PUBMED   11953883
  REMARK    GeneRIF: Carcinoma samples displaying reduced levels of MCT1 were
            found to express the high affinity glucose transporter, GLUT1,
            suggesting that there is a switch from butyrate to glucose as an
            energy source in colonic epithelia during transition to malignancy
REFERENCE   5  (bases 1 to 3410)
  AUTHORS   Cuff,M.A. and Shirazi-Beechey,S.P.
  TITLE     The human monocarboxylate transporter, MCT1: genomic organization
            and promoter analysis
  JOURNAL   Biochem. Biophys. Res. Commun. 292 (4), 1048-1056 (2002)
   PUBMED   11944921
  REMARK    GeneRIF: the structural organization of the human MCT1 gene and
            5'-flanking region which contains potential binding sites for a
            variety of transcription factors with known association with
            butyrate's action in the colon
REFERENCE   6  (bases 1 to 3410)
  AUTHORS   Cuff,M.A., Lambert,D.W. and Shirazi-Beechey,S.P.
  TITLE     Substrate-induced regulation of the human colonic monocarboxylate
            transporter, MCT1
  JOURNAL   J. Physiol. (Lond.) 539 (Pt 2), 361-371 (2002)
   PUBMED   11882670
  REMARK    GeneRIF: substrate-induced regulation of human colonic MCT1.  The
            basis of this regulation is a butyrate-induced increase in mRNA
            abundance, resulting from the dual control of gene transcription
            and stability of the transcript
REFERENCE   7  (bases 1 to 3410)
  AUTHORS   Garcia,C.K., Li,X., Luna,J. and Francke,U.
  TITLE     cDNA cloning of the human monocarboxylate transporter 1 and
            chromosomal localization of the SLC16A1 locus to 1p13.2-p12
  JOURNAL   Genomics 23 (2), 500-503 (1994)
   PUBMED   7835905
REFERENCE   8  (bases 1 to 3410)
  AUTHORS   Garcia,C.K., Goldstein,J.L., Pathak,R.K., Anderson,R.G. and
            Brown,M.S.
  TITLE     Molecular characterization of a membrane transporter for lactate,
            pyruvate, and other monocarboxylates: implications for the Cori
            cycle
  JOURNAL   Cell 76 (5), 865-873 (1994)
   PUBMED   8124722
REFERENCE   9  (bases 1 to 3410)
  AUTHORS   Kim,C.M., Goldstein,J.L. and Brown,M.S.
  TITLE     cDNA cloning of MEV, a mutant protein that facilitates cellular
            uptake of mevalonate, and identification of the point mutation
            responsible for its gain of function
  JOURNAL   J. Biol. Chem. 267 (32), 23113-23121 (1992)
   PUBMED   1429658
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL162079.1.
            On Apr 4, 2002 this sequence version replaced gi:4506982.
FEATURES             Location/Qualifiers
     source          1..3410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..3410
                     /gene="SLC16A1"
                     /note="synonyms: MCT, MCT1"
                     /db_xref="GeneID:6566"
                     /db_xref="MIM:600682"
     CDS             194..1696
                     /gene="SLC16A1"
                     /note="monocarboxylate transporter 1;
                     go_component: membrane fraction [goid 0005624] [evidence
                     TAS] [pmid 8124722];
                     go_component: integral to membrane [goid 0016021]
                     [evidence TAS] [pmid 1429658];
                     go_function: symporter activity [goid 0015293] [evidence
                     IEA];
                     go_function: transporter activity [goid 0005215] [evidence
                     IEA];
                     go_function: monocarboxylate porter activity [goid
                     0015355] [evidence IEA];
                     go_function: mevalonate transporter activity [goid
                     0015130] [evidence TAS] [pmid 1429658];
                     go_process: transport [goid 0006810] [evidence IEA];
                     go_process: mevalonate transport [goid 0015728] [evidence
                     TAS] [pmid 1429658]"
                     /codon_start=1
                     /product="solute carrier family 16, member 1"
                     /protein_id="NP_003042.2"
                     /db_xref="GI:19923753"
                     /db_xref="GeneID:6566"
                     /db_xref="MIM:600682"
                     /translation="MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFF
                     KEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIA
                     ASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCT
                     LAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAG
                     KSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFG
                     LFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFA
                     ASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVG
                     LVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAK
                     EQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTEGGPKEEESPV"
     polyA_signal    3329..3334
                     /gene="SLC16A1"
     polyA_site      3355
                     /gene="SLC16A1"
ORIGIN      
        1 tgcgacgtga ctggctagct gcgtgggtac tggaacaagc aaacgaggca gcgagcgaag
       61 gacgggagcc ggaccctggg ccccgtggaa ctccagcctg cgccaccacg tcacgcacac
      121 gctcggcgct gcgatccgcg catataacga tatttggatt tgacctgcat tttggaattt
      181 atctacactt aaaatgccac cagcagttgg aggtccagtt ggatacaccc ccccagatgg
      241 aggctggggc tgggcagtgg taattggagc tttcatttcc atcggcttct cttatgcatt
      301 tcccaaatca attactgtct tcttcaaaga gattgaaggt atattccatg ccaccaccag
      361 cgaagtgtca tggatatcct ccataatgtt ggctgtcatg tatggtggag gtcctatcag
      421 cagtatcctg gtgaataaat atggaagtcg tatagtcatg attgttggtg gctgcttgtc
      481 aggctgtggc ttgattgcag cttctttctg taacaccgta cagcaactat acgtctgtat
      541 tggagtcatt ggaggtcttg ggcttgcctt caacttgaat ccagctctga ccatgattgg
      601 caagtatttc tacaagaggc gaccattggc caacggactg gccatggcag gcagccctgt
      661 gttcctctgt actctggccc ccctcaatca ggttttcttc ggtatctttg gatggagagg
      721 aagctttcta attcttgggg gcttgctact aaactgctgt gttgctggag ccctcatgcg
      781 accaatcggg cccaagccaa ccaaggcagg gaaagataag tctaaagcat cccttgagaa
      841 agctggaaaa tctggtgtga aaaaagatct gcatgatgca aatacagatc ttattggaag
      901 acaccctaaa caagagaaac gatcagtctt ccaaacaatt aatcagttcc tggacttaac
      961 cctattcacc cacagaggct ttttgctata cctctctgga aatgtgatca tgttttttgg
     1021 actctttgca cctttggtgt ttcttagtag ttatgggaag agtcagcatt attctagtga
     1081 gaagtctgcc ttccttcttt ccattctggc ttttgttgac atggtagccc gaccatctat
     1141 gggacttgta gccaacacaa agccaataag acctcgaatt cagtatttct ttgcggcttc
     1201 cgttgttgca aatggagtgt gtcatatgct agcaccttta tccactacct atgttggatt
     1261 ctgtgtctat gcgggattct ttggatttgc cttcgggtgg ctcagctccg tattgtttga
     1321 aacattgatg gaccttgttg gaccccagag gttctccagc gctgtgggat tggtgaccat
     1381 tgtggaatgc tgtcctgtcc tcctggggcc accactttta ggtcggctca atgacatgta
     1441 tggagactac aaatacacat actgggcatg tggcgtcgtc ctaattattt caggtatcta
     1501 tctcttcatt ggcatgggca tcaattatcg acttttggca aaagaacaga aagcaaacga
     1561 gcagaaaaag gaaagtaaag aggaagagac cagtatagat gttgctggga agccaaatga
     1621 agttaccaaa gcagcagaat ctccggacca gaaagacaca gaaggagggc ccaaggagga
     1681 ggaaagtcca gtctgaatcc atggggctga agggtaaatt gagcagttca tgacccagga
     1741 tatctgaaaa tattctactg gcctgtaatc taccagtggt gctcaatgca aatagtagac
     1801 atttgtgtgg aaatcatacc agttgttcat tgatgggatt tttgtttgac tccttaccaa
     1861 tagcctgaat ttgaggaggg aatgattggt agcaaaggat gggggaaaga agtaggttct
     1921 gttttgtttt gttttaatct tagcttttaa tagtgtcata aagattataa tatgtgcctt
     1981 aagttttagt ctttagaact ctagagagcc ttaacttctt aaaccatttt tgctgaattc
     2041 atctatttcg agtgttgtgt taaaaggaaa aataacaact aacttgtttg aggcaaatct
     2101 aaaatttaaa attaatcttg cttcattgtt acatgtaata tatttcagac attttcactg
     2161 gaagatttat gaacagaaat attggttgaa agttagagat tttacaaaat gctgacaaaa
     2221 atattttcct agcatcagta gatttctggc atatgtttct gctagctata tatttaggaa
     2281 attcaaagca taaaactttg gcaacatctt ggctgttcta gacacagtgt acttgtcaac
     2341 ccctctcagg taccttttct tgggatgctt attagaagcc aagtaaagtg cttaaggttt
     2401 gttttcatta aattagctat ttctgctccc ctgttcaaag atgcattttg agtgtttata
     2461 gatcactgcc ctttttgaaa tcacctggta ttatttttct tactggaaaa gttagtatta
     2521 aaatctacag aactacatat ttgtgcctcc ttggtaaata caacacatct aattaaatgt
     2581 agacagatat ttcaaacatc agctgaattc acttaagttt ttccaaaacc tcagttaaac
     2641 tgtgaagcta ttggaatttt tttttcctgg aatttttccc ctttgattca cagtggtccc
     2701 atttatatct gcttctagct tagtgctatg tgtgagatat gtgtgtgttt ggtgtttttg
     2761 tttttttgtt tttttttttt taaggtttgc aaattaaaaa gggccagaaa aatttggcac
     2821 caggcaaacg aataaagata ggattgggaa agaagttgct aagtgtgctt agttttaata
     2881 agtaattcct tctctttttt cagagaaggc cttacagaaa attgttgtgc ttagaattgc
     2941 tggatgcatt tttaccctcc acacaaacct aaaaattttg tgaccccttt cacttacctg
     3001 aaaagtagag aaatggattc agtataagga taaggaggga aggtggacca gaatgaaaac
     3061 tgtaaatatt tttttaacct aatatcactt aaatcgaggc agaaagatat agacattcaa
     3121 tgaattatat tcaatgcatt taaaatacca ctgtaattga cagagtaaaa gtatagatac
     3181 aaaaccttgt gtaagaggct gacttttcca aataaacatt ttttaagaaa acatttcttc
     3241 tcccaaatgt ctattttctt gaggaaaata ttgctgtgtc ttcattttca ttaccaggtt
     3301 tcattttggg ccttgctaaa ttgattgaat taaatcctcc agcttttgaa ccttgaaaaa
     3361 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa agaaaaaaaa aaaaaaaaag
//

LOCUS       NM_003060               3252 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens solute carrier family 22 (organic cation transporter),
            member 5 (SLC22A5), mRNA.
ACCESSION   NM_003060
VERSION     NM_003060.2  GI:24497491
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Lahjouji,K., Elimrani,I., Lafond,J., Leduc,L., Qureshi,I.A. and
            Mitchell,G.A.
  TITLE     L-Carnitine transport in human placental brush-border membranes is
            mediated by the sodium-dependent organic cation transporter OCTN2
  JOURNAL   Am. J. Physiol., Cell Physiol. 287 (2), C263-C269 (2004)
   PUBMED   15238359
  REMARK    GeneRIF: The reported properties of OCTN2 resemble those observed
            for l-carnitine uptake in placental brush border vesicles,
            suggesting that OCTN2 may mediate most maternofetal carnitine
            transport in humans.
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Peltekova,V.D., Wintle,R.F., Rubin,L.A., Amos,C.I., Huang,Q.,
            Gu,X., Newman,B., Van Oene,M., Cescon,D., Greenberg,G.,
            Griffiths,A.M., St George-Hyslop,P.H. and Siminovitch,K.A.
  TITLE     Functional variants of OCTN cation transporter genes are associated
            with Crohn disease
  JOURNAL   Nat. Genet. 36 (5), 471-475 (2004)
   PUBMED   15107849
  REMARK    GeneRIF: a G-->C transversion in trhe promoter of SLC22A5 is
            associated with Crohn disease
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Amat di San Filippo,C. and Longo,N.
  TITLE     Tyrosine residues affecting sodium stimulation of carnitine
            transport in the OCTN2 carnitine/organic cation transporter
  JOURNAL   J. Biol. Chem. 279 (8), 7247-7253 (2004)
   PUBMED   14665638
  REMARK    GeneRIF: tyrosine residues are involved in coupling the sodium
            electrochemical gradient to transmembrane solute transfer in the
            sodium-dependent co-transporter OCTN2
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Amat di San Filippo,C., Wang,Y. and Longo,N.
  TITLE     Functional domains in the carnitine transporter OCTN2, defective in
            primary carnitine deficiency
  JOURNAL   J. Biol. Chem. 278 (48), 47776-47784 (2003)
   PUBMED   14506273
  REMARK    GeneRIF: multiple domains of the OCTN2 transporter are required for
            carnitine transport
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Karlic,H., Lohninger,A., Laschan,C., Lapin,A., Bohmer,F.,
            Huemer,M., Guthann,E., Rappold,E. and Pfeilstocker,M.
  TITLE     Downregulation of carnitine acyltransferases and organic cation
            transporter OCTN2 in mononuclear cells in healthy elderly and
            patients with myelodysplastic syndromes
  JOURNAL   J. Mol. Med. 81 (7), 435-442 (2003)
   PUBMED   12802501
  REMARK    GeneRIF: downregulated in elderly persons and in myelodysplastic
            syndrome patients; reduction was more than 85% compared to younger
            adults
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Elimrani,I., Lahjouji,K., Seidman,E., Roy,M.J., Mitchell,G.A. and
            Qureshi,I.
  TITLE     Expression and localization of organic cation/carnitine transporter
            OCTN2 in Caco-2 cells
  JOURNAL   Am. J. Physiol. Gastrointest. Liver Physiol. 284 (5), G863-G871
            (2003)
   PUBMED   12684216
  REMARK    GeneRIF: Demonstration that l-carnitine uptake in differentiated
            Caco-2 cells is primarily mediated by OCTN2, located on the brush
            border membrane
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Rahbeeni,Z., Vaz,F.M., Al-Hussein,K., Bucknall,M.P., Ruiter,J.,
            Wanders,R.J. and Rashed,M.S.
  TITLE     Identification of two novel mutations in OCTN2 from two Saudi
            patients with systemic carnitine deficiency
  JOURNAL   J. Inherit. Metab. Dis. 25 (5), 363-369 (2002)
   PUBMED   12408185
  REMARK    GeneRIF: novel missense mutations in the OCTN2 gene (1340A >G and
            83G>T) were found in two Saudi patients with sytemic carnitine
            deficiency
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Ohashi,R., Tamai,I., Inano,A., Katsura,M., Sai,Y., Nezu,J. and
            Tsuji,A.
  TITLE     Studies on functional sites of organic cation/carnitine transporter
            OCTN2 (SLC22A5) using a Ser467Cys mutant protein
  JOURNAL   J. Pharmacol. Exp. Ther. 302 (3), 1286-1294 (2002)
   PUBMED   12183691
  REMARK    GeneRIF: has functional sites for carnitine and Na(+) and
            carnitine-binding site is involved, in part, in the recognition of
            organic cations
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Wu,X., Huang,W., Prasad,P.D., Seth,P., Rajan,D.P., Leibach,F.H.,
            Chen,J., Conway,S.J. and Ganapathy,V.
  TITLE     Functional characteristics and tissue distribution pattern of
            organic cation transporter 2 (OCTN2), an organic cation/carnitine
            transporter
  JOURNAL   J. Pharmacol. Exp. Ther. 290 (3), 1482-1492 (1999)
   PUBMED   10454528
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Nezu,J., Tamai,I., Oku,A., Ohashi,R., Yabuuchi,H., Hashimoto,N.,
            Nikaido,H., Sai,Y., Koizumi,A., Shoji,Y., Takada,G., Matsuishi,T.,
            Yoshino,M., Kato,H., Ohura,T., Tsujimoto,G., Hayakawa,J.,
            Shimane,M. and Tsuji,A.
  TITLE     Primary systemic carnitine deficiency is caused by mutations in a
            gene encoding sodium ion-dependent carnitine transporter
  JOURNAL   Nat. Genet. 21 (1), 91-94 (1999)
   PUBMED   9916797
REFERENCE   11 (bases 1 to 3252)
  AUTHORS   Tamai,I., Ohashi,R., Nezu,J., Yabuuchi,H., Oku,A., Shimane,M.,
            Sai,Y. and Tsuji,A.
  TITLE     Molecular and functional identification of sodium ion-dependent,
            high affinity human carnitine transporter OCTN2
  JOURNAL   J. Biol. Chem. 273 (32), 20378-20382 (1998)
   PUBMED   9685390
REFERENCE   12 (bases 1 to 3252)
  AUTHORS   Shoji,Y., Koizumi,A., Kayo,T., Ohata,T., Takahashi,T., Harada,K.
            and Takada,G.
  TITLE     Evidence for linkage of human primary systemic carnitine deficiency
            with D5S436: a novel gene locus on chromosome 5q
  JOURNAL   Am. J. Hum. Genet. 63 (1), 101-108 (1998)
   PUBMED   9634512
REFERENCE   13 (bases 1 to 3252)
  AUTHORS   Wu,X., Prasad,P.D., Leibach,F.H. and Ganapathy,V.
  TITLE     cDNA sequence, transport function, and genomic organization of
            human OCTN2, a new member of the organic cation transporter family
  JOURNAL   Biochem. Biophys. Res. Commun. 246 (3), 589-595 (1998)
   PUBMED   9618255
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF057164.1.
            On Nov 3, 2002 this sequence version replaced gi:4507004.
            
            Summary: Polyspecific organic cation transporters in the liver,
            kidney, intestine, and other organs are critical for elimination of
            many endogenous small organic cations as well as a wide array of
            drugs and environmental toxins. The encoded protein is a plasma
            integral membrane protein which functions both as an organic cation
            transporter and as a sodium-dependent high affinity carnitine
            transporter. The encoded protein is involved in the active cellular
            uptake of carnitine. Mutations in this gene are the cause of
            systemic primary carnitine deficiency (CDSP), an autosomal
            recessive disorder manifested early in life by hypoketotic
            hypoglycemia and acute metabolic decompensation, and later in life
            by skeletal myopathy or cardiomyopathy.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31"
     gene            1..3252
                     /gene="SLC22A5"
                     /note="synonym: OCTN2"
                     /db_xref="GeneID:6584"
                     /db_xref="MIM:603377"
     CDS             222..1895
                     /gene="SLC22A5"
                     /note="organic cation transporter 5; organic
                     cation/carnitine transporter 2; high-affinity sodium
                     dependent carnitine cotransporter;
                     go_component: plasma membrane [goid 0005886] [evidence
                     TAS] [pmid 9685390];
                     go_component: plasma membrane [goid 0005886] [evidence
                     TAS] [pmid 9916797];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: symporter activity [goid 0015293] [evidence
                     IEA];
                     go_function: ion transporter activity [goid 0015075]
                     [evidence IEA];
                     go_function: carnitine transporter activity [goid 0015226]
                     [evidence TAS] [pmid 9685390];
                     go_process: ion transport [goid 0006811] [evidence IEA];
                     go_process: sodium ion transport [goid 0006814] [evidence
                     IEA];
                     go_process: carnitine transport [goid 0015879] [evidence
                     TAS] [pmid 9685390]"
                     /codon_start=1
                     /product="solute carrier family 22 member 5"
                     /protein_id="NP_003051.1"
                     /db_xref="GI:4507005"
                     /db_xref="GeneID:6584"
                     /db_xref="MIM:603377"
                     /translation="MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIA
                     TPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRD
                     VDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFIS
                     GQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLG
                     TEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWF
                     IPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDL
                     LRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWL
                     LLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYT
                     AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLF
                     LPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF"
     polyA_site      2816
                     /gene="SLC22A5"
     polyA_site      3237
                     /gene="SLC22A5"
                     /evidence=experimental
ORIGIN      
        1 gcggcccagg cccgcaacct tccctggtcg tgcgccctat gtaaggccag ccgcggcagg
       61 accaaggcgg cggtgtcagc tcgcgagcct accctccgcg gacggtcttg ggtcgcctgc
      121 tgcctggctt gcctggtcgg cggcgggtgc cccgcgcgca cgcgcaaagc ccgccgcgtt
      181 ccccgacccc aggccgcgct ctgtgggcct ctgagggcgg catgcgggac tacgacgagg
      241 tgaccgcctt cctgggcgag tgggggccct tccagcgcct catcttcttc ctgctcagcg
      301 ccagcatcat ccccaatggc ttcaccggcc tgtcctccgt gttcctgata gcgaccccgg
      361 agcaccgctg ccgggtgccg gacgccgcga acctgagcag cgcctggcgc aaccacactg
      421 tcccactgcg gctgcgggac ggccgcgagg tgccccacag ctgccgccgc taccggctcg
      481 ccaccatcgc caacttctcg gcgcttgggc tggagccggg gcgcgacgtg gacctggggc
      541 agctggagca ggagagctgt ctggatggct gggagttcag tcaggacgtc tacctgtcca
      601 ccattgtgac cgagtggaac ctggtgtgtg aggacgactg gaaggcccca ctcacaatct
      661 ccttgttctt cgtgggtgtg ctgttgggct ccttcatttc agggcagctg tcagacaggt
      721 ttggccggaa gaatgtgctg ttcgtgacca tgggcatgca gacaggcttc agcttcctgc
      781 agatcttctc gaagaatttt gagatgtttg tcgtgctgtt tgtccttgta ggcatgggcc
      841 agatctccaa ctatgtggca gcatttgtcc tggggacaga aattcttggc aagtcagttc
      901 gtataatatt ctctacgtta ggagtgtgca tattttatgc atttggctac atggtgctgc
      961 cactgtttgc ttacttcatc cgagactggc ggatgctgct ggtggcgctg acgatgccgg
     1021 gggtgctatg cgtggcactc tggtggttca tccctgagtc cccccgatgg ctcatctctc
     1081 agggacgatt tgaagaggca gaggtgatca tccgcaaggc tgccaaagcc aatgggattg
     1141 ttgtgccttc cactatcttt gacccgagtg agttacaaga cctaagttcc aagaagcagc
     1201 agtcccacaa cattctggat ctgcttcgaa cctggaatat ccggatggtc accatcatgt
     1261 ccataatgct gtggatgacc atatcagtgg gctattttgg gctttcgctt gatactccta
     1321 acttgcatgg ggacatcttt gtgaactgct tcctttcagc gatggttgaa gtcccagcat
     1381 atgtgttggc ctggctgctg ctgcaatatt tgccccggcg ctattccatg gccactgccc
     1441 tcttcctggg tggcagtgtc cttctcttca tgcagctggt acccccagac ttgtattatt
     1501 tggctacagt cctggtgatg gtgggcaagt ttggagtcac ggctgccttt tccatggtct
     1561 acgtgtacac agccgagctg tatcccacag tggtgagaaa catgggtgtg ggagtcagct
     1621 ccacagcatc ccgcctgggc agcatcctgt ctccctactt cgtttacctt ggtgcctacg
     1681 accgcttcct gccctacatt ctcatgggaa gtctgaccat cctgacagcc atcctcacct
     1741 tgtttctccc agagagcttc ggtaccccac tcccagacac cattgaccag atgctaagag
     1801 tcaaaggaat gaaacacaga aaaactccaa gtcacacaag gatgttaaaa gatggtcaag
     1861 aaaggcccac aatccttaaa agcacagcct tctaacatcg cttccagtaa gggagaaact
     1921 gaagaggaaa gactgtcttg ccagaaatgg ccagcttgtg cagactccga gtccttcagt
     1981 gacaaaggcc tttgctgttt gtcctcttga cctgtgtctg acttgctcct ggatgggcac
     2041 ccacactcag aggctacata tggccctaga gcaccacctt cctctaggga cactggggct
     2101 acctacagac aacttcatct aagtcctaac tattacaatg atggactcag cacctccaaa
     2161 gcagttaatt tttcactaga accagtgaga tctggaggaa tgtgagaagc atatgctaaa
     2221 tgtacatttt aattttagac tacttgaaaa ggcccctaat aaggctagag gtctaagtcc
     2281 cccacccctt tccccactcc cctctagtgg tgaactttag aggaaaagga agtaattgca
     2341 caaggagttt gattcttacc ttttctcagt tacagaggac attaactgga tcattgcttc
     2401 cccagggcag gagagcgcag agctagggaa agtgaaaggt aatgaagatg gagcagaatg
     2461 agcagatgca gatcaccagc aaagtgcact gatgtgtgag ctcttaagac cactcagcat
     2521 gacgactgag tagacttgtt tacatctgat caaagcactg ggcttgtcca ggctcataat
     2581 aaatgctcca ttgaatctac tattcttgtt ttccactgct gtggaaacct ccttgctact
     2641 atagcgtctt atgtatggtt taaaggaaat ttatcaggtg agagagatga gcaacgttgt
     2701 cttttctctc aaagctgtaa tgtgggtttt gttttattgt ttatttgttt gttgttgtat
     2761 ccttttctcc ttgttatttg cccttcagaa tgcacttggg aaaggctggt tccttagcct
     2821 cctggtttgt gtcttttttt tttttttttt aaacacagaa tcactctggc aattgtctgc
     2881 agctgccact ggtgcaaggc cttaccagcc ctagcctcta gcacttctct aagtgccaaa
     2941 aacagtgtca ttgtgtgtgt tcctttcttg atacttagtc atgggaggat attacaaaaa
     3001 agaaatttaa attgtgttca tagtctttca gagtagctca ctttagtcct gtaactttat
     3061 tgggtgatat tttgtgttca gtgtaattgt cttctctttg ctgattatgt taccatggta
     3121 ctcctaaagc atatgcctca cctggttaaa aaagaacaaa catgtttttg tgaaagctac
     3181 tgaagtgcct tgggaaatga gaaagtttta ataagtaaaa tgatttttta aatatcaaaa
     3241 aaaaaaaaaa aa
//

LOCUS       NM_003068               2101 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens snail homolog 2 (Drosophila) (SNAI2), mRNA.
ACCESSION   NM_003068
VERSION     NM_003068.3  GI:24497625
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Kajita,M., McClinic,K.N. and Wade,P.A.
  TITLE     Aberrant expression of the transcription factors snail and slug
            alters the response to genotoxic stress
  JOURNAL   Mol. Cell. Biol. 24 (17), 7559-7566 (2004)
   PUBMED   15314165
  REMARK    GeneRIF: Results suggest that aberrant expression of Snail or Slug
            may promote tumorigenesis through increased resistance to
            programmed cell death.
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Sanchez-Martin,M., Rodriguez-Garcia,A., Perez-Losada,J.,
            Sagrera,A., Read,A.P. and Sanchez-Garcia,I.
  TITLE     SLUG (SNAI2) deletions in patients with Waardenburg disease
  JOURNAL   Hum. Mol. Genet. 11 (25), 3231-3236 (2002)
   PUBMED   12444107
  REMARK    GeneRIF: Absence of SLUG causes the auditory-pigmentary symptoms in
            at least some individuals with Wardenburg syndrome type 2.
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Hajra,K.M., Chen,D.Y. and Fearon,E.R.
  TITLE     The SLUG zinc-finger protein represses E-cadherin in breast cancer
  JOURNAL   Cancer Res. 62 (6), 1613-1618 (2002)
   PUBMED   11912130
  REMARK    GeneRIF: The SLUG zinc-finger protein represses E-cadherin in
            breast cancer.
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Hemavathy,K., Guru,S.C., Harris,J., Chen,J.D. and Ip,Y.T.
  TITLE     Human Slug is a repressor that localizes to sites of active
            transcription
  JOURNAL   Mol. Cell. Biol. 20 (14), 5087-5095 (2000)
   PUBMED   10866665
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   Inukai,T., Inoue,A., Kurosawa,H., Goi,K., Shinjyo,T., Ozawa,K.,
            Mao,M., Inaba,T. and Look,A.T.
  TITLE     SLUG, a ces-1-related zinc finger transcription factor gene with
            antiapoptotic activity, is a downstream target of the E2A-HLF
            oncoprotein
  JOURNAL   Mol. Cell 4 (3), 343-352 (1999)
   PUBMED   10518215
REFERENCE   6  (bases 1 to 2101)
  AUTHORS   Stegmann,K., Boecker,J., Kosan,C., Ermert,A., Kunz,J. and Koch,M.C.
  TITLE     Human transcription factor SLUG: mutation analysis in patients with
            neural tube defects and identification of a missense mutation
            (D119E) in the Slug subfamily-defining region
  JOURNAL   Mutat. Res. 406 (2-4), 63-69 (1999)
   PUBMED   10479723
REFERENCE   7  (bases 1 to 2101)
  AUTHORS   Cohen,M.E., Yin,M., Paznekas,W.A., Schertzer,M., Wood,S. and
            Jabs,E.W.
  TITLE     Human SLUG gene organization, expression, and chromosome map
            location on 8q
  JOURNAL   Genomics 51 (3), 468-471 (1998)
   PUBMED   9721220
REFERENCE   8  (bases 1 to 2101)
  AUTHORS   Savagner,P., Yamada,K.M. and Thiery,J.P.
  TITLE     The zinc-finger protein slug causes desmosome dissociation, an
            initial and necessary step for growth factor-induced
            epithelial-mesenchymal transition
  JOURNAL   J. Cell Biol. 137 (6), 1403-1419 (1997)
   PUBMED   9182671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014890.1, AA410443.1 and
            BG706203.1.
            On Nov 3, 2002 this sequence version replaced gi:19923158.
            
            Summary: This gene encodes a member of the Snail family of
            C2H2-type zinc finger transcription factors. The encoded protein
            acts as a transcriptional repressor that binds to E-box motifs and
            is also likely to repress E-cadherin transcription in breast
            carcinoma. This protein is involved in epithelial-mesenchymal
            transitions and has antiapoptotic activity. Mutations in this gene
            may be associated with sporatic cases of neural tube defects.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2101
                     /gene="SNAI2"
                     /note="synonyms: SLUG, WS2D, SLUGH1, MGC10182"
                     /db_xref="GeneID:6591"
                     /db_xref="MIM:602150"
     CDS             165..971
                     /gene="SNAI2"
                     /note="slug (chicken homolog), zinc finger protein; neural
                     crest transcription factor SLUG; slug homolog, zinc finger
                     protein (chicken);
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     10866665];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: zinc ion binding [goid 0008270] [evidence
                     IEA];
                     go_process: development [goid 0007275] [evidence IEA];
                     go_process: ectoderm and mesoderm interaction [goid
                     0007499] [evidence TAS] [pmid 9182671];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA];
                     go_process: negative regulation of transcription from Pol
                     II promoter [goid 0000122] [evidence TAS] [pmid 10866665]"
                     /codon_start=1
                     /product="snail 2"
                     /protein_id="NP_003059.1"
                     /db_xref="GI:11276067"
                     /db_xref="GeneID:6591"
                     /db_xref="MIM:602150"
                     /translation="MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQ
                     PEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGS
                     ESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFS
                     CKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHC
                     NRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH"
     polyA_signal    1989..1994
                     /gene="SNAI2"
     polyA_site      2010
                     /gene="SNAI2"
                     /evidence=experimental
ORIGIN      
        1 agttcgtaaa ggagccgggt gacttcagag gcgccggccc gtccgtctgc cgcacctgag
       61 cacggcccct gcccgagcct ggcccgccgc gatgctgtag ggaccgccgt gtcctcccgc
      121 cggaccgtta tccgcgccgg gcgcccgcca gacccgctgg caagatgccg cgctccttcc
      181 tggtcaagaa gcatttcaac gcctccaaaa agccaaacta cagcgaactg gacacacata
      241 cagtgattat ttccccgtat ctctatgaga gttactccat gcctgtcata ccacaaccag
      301 agatcctcag ctcaggagca tacagcccca tcactgtgtg gactaccgct gctccattcc
      361 acgcccagct acccaatggc ctctctcctc tttccggata ctcctcatct ttggggcgag
      421 tgagtccccc tcctccatct gacacctcct ccaaggacca cagtggctca gaaagcccca
      481 ttagtgatga agaggaaaga ctacagtcca agctttcaga cccccatgcc attgaagctg
      541 aaaagtttca gtgcaattta tgcaataaga cctattcaac tttttctggg ctggccaaac
      601 ataagcagct gcactgcgat gcccagtcta gaaaatcttt cagctgtaaa tactgtgaca
      661 aggaatatgt gagcctgggc gccctgaaga tgcatattcg gacccacaca ttaccttgtg
      721 tttgcaagat ctgcggcaag gcgttttcca gaccctggtt gcttcaagga cacattagaa
      781 ctcacacggg ggagaagcct ttttcttgcc ctcactgcaa cagagcattt gcagacaggt
      841 caaatctgag ggctcatctg cagacccatt ctgatgtaaa gaaataccag tgcaaaaact
      901 gctccaaaac cttctccaga atgtctctcc tgcacaaaca tgaggaatct ggctgctgtg
      961 tagcacactg agtgacgcaa tcaatgttta ctcgaacaga atgcatttct tcactccgaa
     1021 gccaaatgac aaataaagtc caaaggcatt ttctcctgtg ctgaccaacc aaataatatg
     1081 tatagacaca cacacatatg cacacacaca cacacacacc cacagagaga gagctgcaag
     1141 agcatggaat tcatgtgttt aaagataatc ctttccatgt gaagtttaaa attactatat
     1201 atttgctgat ggctagattg agagaataaa agacagtaac ctttctcttc aaagataaaa
     1261 tgaaaagcac attgcatctt ttcttcctaa aaaaatgcaa agatttacat tgctgccaaa
     1321 tcatttcaac tgaaaagaac agtattgctt tgtaatagag tctgtaatag gatttcccat
     1381 aggaagagat ctgccagacg cgaactcagg tgccttaaaa agtattccaa gtttactcca
     1441 ttacatgtcg gttgtctggt tgccattgtt gaactaaagc ctttttttga ttacctgtag
     1501 tgctttaaag tatattttta aaagggagga aaaaaataac aagaacaaaa cacaggagaa
     1561 tgtattaaaa gtatttttgt tttgttttgt ttttgccaat taacagtatg tgccttgggg
     1621 gaggagggaa agattagctt tgaacattcc tggcgcatgc tccattgtct tactatttta
     1681 aaacatttta ataatttttg aaaattaatt aaagatggga ataagtgcaa aagaggattc
     1741 ttacaaattc attaatgtac ttaaactatt tcaaatgcat accacaaatg caataataca
     1801 ataccccttc caagtgcctt tttaaattgt atagttgatg agtcaatgta aatttgtgtt
     1861 tatttttata tgattgaatg agttctgtat gaaactgaga tgttgtctat agctatgtct
     1921 ataaacaacc tgaagacttg tgaaatcaat gtttcttttt taaaaaacaa ttttcaagtt
     1981 ttttttacaa taaacagttt tgatttaaaa tctcgtttgt atactatttt cagagacttt
     2041 acttgcttca tgattagtac caaaccactg tacaaagaat tgtttgttaa caagaaaaaa
     2101 a
//

LOCUS       NM_003765                750 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens syntaxin 10 (STX10), mRNA.
ACCESSION   NM_003765
VERSION     NM_003765.1  GI:4507284
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Tang,B.L., Low,D.Y., Tan,A.E. and Hong,W.
  TITLE     Syntaxin 10: a member of the syntaxin family localized to the
            trans-Golgi network
  JOURNAL   Biochem. Biophys. Res. Commun. 242 (2), 345-350 (1998)
   PUBMED   9446797
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF035531.1.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..750
                     /gene="STX10"
                     /note="synonyms: SYN10, hsyn10"
                     /db_xref="GeneID:8677"
                     /db_xref="MIM:603765"
     CDS             1..750
                     /gene="STX10"
                     /note="go_component: Golgi membrane [goid 0000139]
                     [evidence TAS] [pmid 9446797];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_process: protein transport [goid 0015031] [evidence
                     IEA]"
                     /codon_start=1
                     /product="syntaxin 10"
                     /protein_id="NP_003756.1"
                     /db_xref="GI:4507285"
                     /db_xref="GeneID:8677"
                     /db_xref="MIM:603765"
                     /translation="MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELD
                     WTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEM
                     KDHMVSPTAVAFLERNNREILAGKPAAQKSPSDLLDASAVSATSRYIEEQQATQQLIM
                     DEQDQQLEMVSGSIQVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAK
                     VSHMTSDRRQWCAIAVLVGVLLLVLILLFSL"
ORIGIN      
        1 atgtctctcg aagacccctt ttttgtagtc cgaggcgagg tgcagaaggc ggtgaacacg
       61 gcccgcgggc tgtaccagcg ctggtgcgag ctcctgcagg aaagcgcggc ggtcggacgc
      121 gaggagctgg actggacgac caatgagctg cggaatggcc tgcgcagcat cgagtgggac
      181 ctcgaggacc tggaagagac catcggtata gtggaagcca acccaggcaa gttcaagctc
      241 ccagccgggg acctgcagga gagaaaggtg ttcgtggagc ggatgcgaga ggcagtccag
      301 gaaatgaagg accatatggt cagcccaaca gccgtagcat ttttggagag gaataacaga
      361 gagatactcg caggcaagcc agctgcccag aagtcaccca gcgacctgct ggatgccagc
      421 gcagtctcgg ccacatctcg ctacatcgag gagcagcagg ccacacagca gctgatcatg
      481 gatgaacagg atcaacagct ggagatggtg tctgggagca tccaggttct gaagcacatg
      541 tccggccgcg ttggagaaga gctggacgag cagggcatca tgctggatgc cttcgcccaa
      601 gagatggacc acacccagtc ccgcatggac ggggtcctca ggaagttggc caaagtatcc
      661 cacatgacga gtgaccgccg acagtggtgt gccatcgccg tgctagtggg ggtgcttctc
      721 ctcgttctca tcttactatt ctctctctga
//

LOCUS       NM_003870               7219 bp    mRNA    linear   PRI 07-JAN-2005
DEFINITION  Homo sapiens IQ motif containing GTPase activating protein 1
            (IQGAP1), mRNA.
ACCESSION   NM_003870
VERSION     NM_003870.3  GI:57242794
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7219)
  AUTHORS   Lui,W.Y., Mruk,D.D. and Cheng,C.Y.
  TITLE     Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein
            complex regulate Sertoli-germ cell adherens junction dynamics in
            the testis
  JOURNAL   J. Cell. Physiol. 202 (1), 49-66 (2005)
   PUBMED   15389538
REFERENCE   2  (bases 1 to 7219)
  AUTHORS   Watanabe,T., Wang,S., Noritake,J., Sato,K., Fukata,M., Takefuji,M.,
            Nakagawa,M., Izumi,N., Akiyama,T. and Kaibuchi,K.
  TITLE     Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin
            filaments during cell polarization and migration
  JOURNAL   Dev. Cell 7 (6), 871-883 (2004)
   PUBMED   15572129
REFERENCE   3  (bases 1 to 7219)
  AUTHORS   Tirnauer,J.S.
  TITLE     A new cytoskeletal connection for APC: linked to actin through
            IQGAP
  JOURNAL   Dev. Cell 7 (6), 778-780 (2004)
   PUBMED   15572120
REFERENCE   4  (bases 1 to 7219)
  AUTHORS   Grohmanova,K., Schlaepfer,D., Hess,D., Gutierrez,P., Beck,M. and
            Kroschewski,R.
  TITLE     Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing
            a new type of rho-GTPase regulator
  JOURNAL   J. Biol. Chem. 279 (47), 48495-48504 (2004)
   PUBMED   15355962
REFERENCE   5  (bases 1 to 7219)
  AUTHORS   Suzuki,K., Chikamatsu,Y. and Takahashi,K.
  TITLE     Requirement of protein phosphatase 2A for recruitment of IQGAP1 to
            Rac-bound beta1 integrin
  JOURNAL   (er) J. Cell. Physiol. (2004) In press
   PUBMED   15521075
REFERENCE   6  (bases 1 to 7219)
  AUTHORS   Yamaoka-Tojo,M., Ushio-Fukai,M., Hilenski,L., Dikalov,S.I.,
            Chen,Y.E., Tojo,T., Fukai,T., Fujimoto,M., Patrushev,N.A., Wang,N.,
            Kontos,C.D., Bloom,G.S. and Alexander,R.W.
  TITLE     IQGAP1, a novel vascular endothelial growth factor receptor binding
            protein, is involved in reactive oxygen species--dependent
            endothelial migration and proliferation
  JOURNAL   Circ. Res. 95 (3), 276-283 (2004)
   PUBMED   15217908
REFERENCE   7  (bases 1 to 7219)
  AUTHORS   Izumi,G., Sakisaka,T., Baba,T., Tanaka,S., Morimoto,K. and Takai,Y.
  TITLE     Endocytosis of E-cadherin regulated by Rac and Cdc42 small G
            proteins through IQGAP1 and actin filaments
  JOURNAL   J. Cell Biol. 166 (2), 237-248 (2004)
   PUBMED   15263019
REFERENCE   8  (bases 1 to 7219)
  AUTHORS   Li,Q. and Stuenkel,E.L.
  TITLE     Calcium negatively modulates calmodulin interaction with IQGAP1
  JOURNAL   Biochem. Biophys. Res. Commun. 317 (3), 787-795 (2004)
   PUBMED   15081409
REFERENCE   9  (bases 1 to 7219)
  AUTHORS   Roy,M., Li,Z. and Sacks,D.B.
  TITLE     IQGAP1 binds ERK2 and modulates its activity
  JOURNAL   J. Biol. Chem. 279 (17), 17329-17337 (2004)
   PUBMED   14970219
  REMARK    GeneRIF: IQGAP1 binds ERK2 and modulates its activity
REFERENCE   10 (bases 1 to 7219)
  AUTHORS   Noritake,J., Fukata,M., Sato,K., Nakagawa,M., Watanabe,T.,
            Izumi,N., Wang,S., Fukata,Y. and Kaibuchi,K.
  TITLE     Positive role of IQGAP1, an effector of Rac1, in actin-meshwork
            formation at sites of cell-cell contact
  JOURNAL   Mol. Biol. Cell 15 (3), 1065-1076 (2004)
   PUBMED   14699063
  REMARK    GeneRIF: Rac1 enhances the accumulation of actin filaments,
            E-cadherin, and beta-catenin by acting on IQGAP1.
REFERENCE   11 (bases 1 to 7219)
  AUTHORS   Mataraza,J.M., Briggs,M.W., Li,Z., Entwistle,A., Ridley,A.J. and
            Sacks,D.B.
  TITLE     IQGAP1 promotes cell motility and invasion
  JOURNAL   J. Biol. Chem. 278 (42), 41237-41245 (2003)
  MEDLINE   22917447
   PUBMED   12900413
  REMARK    GeneRIF: IQGAP1 has a fundamental role in cell motility and
            invasion
REFERENCE   12 (bases 1 to 7219)
  AUTHORS   Nauert,J.B., Rigas,J.D. and Lester,L.B.
  TITLE     Identification of an IQGAP1/AKAP79 complex in beta-cells
  JOURNAL   J. Cell. Biochem. 90 (1), 97-108 (2003)
  MEDLINE   22817918
   PUBMED   12938160
  REMARK    GeneRIF: Data suggest that cyclic AMP/protein kinase A may be
            coupled with calcium/calmodulin and guanosine triphosphatases
            through an IQGAP1/AKAP79 complex.
REFERENCE   13 (bases 1 to 7219)
  AUTHORS   Mataraza,J.M., Briggs,M.W., Li,Z., Frank,R. and Sacks,D.B.
  TITLE     Identification and characterization of the Cdc42-binding site of
            IQGAP1
  JOURNAL   Biochem. Biophys. Res. Commun. 305 (2), 315-321 (2003)
  MEDLINE   22630156
   PUBMED   12745076
  REMARK    GeneRIF: Identification and characterization of the Cdc42-binding
            site of IQGAP1.
REFERENCE   14 (bases 1 to 7219)
  AUTHORS   Presslauer,S., Hinterhuber,G., Cauza,K., Horvat,R.,
            Rappersberger,K., Wolff,K. and Foedinger,D.
  TITLE     RasGAP-like protein IQGAP1 is expressed by human keratinocytes and
            recognized by autoantibodies in association with bullous skin
            disease
  JOURNAL   J. Invest. Dermatol. 120 (3), 365-371 (2003)
  MEDLINE   22492748
   PUBMED   12603848
REFERENCE   15 (bases 1 to 7219)
  AUTHORS   Li,Z. and Sacks,D.B.
  TITLE     Elucidation of the interaction of calmodulin with the IQ motifs of
            IQGAP1
  JOURNAL   J. Biol. Chem. 278 (6), 4347-4352 (2003)
  MEDLINE   22450610
   PUBMED   12446675
  REMARK    GeneRIF: interaction of calmodulin with IQ motifs
REFERENCE   16 (bases 1 to 7219)
  AUTHORS   Mbele,G.O., Deloulme,J.C., Gentil,B.J., Delphin,C., Ferro,M.,
            Garin,J., Takahashi,M. and Baudier,J.
  TITLE     The zinc- and calcium-binding S100B interacts and co-localizes with
            IQGAP1 during dynamic rearrangement of cell membranes
  JOURNAL   J. Biol. Chem. 277 (51), 49998-50007 (2002)
  MEDLINE   22370982
   PUBMED   12377780
  REMARK    GeneRIF: IQGAP1 is a potential target protein of S100B during
            processes of dynamic rearrangement of cell membrane morphology
REFERENCE   17 (bases 1 to 7219)
  AUTHORS   Swart-Mataraza,J.M., Li,Z. and Sacks,D.B.
  TITLE     IQGAP1 is a component of Cdc42 signaling to the cytoskeleton
  JOURNAL   J. Biol. Chem. 277 (27), 24753-24763 (2002)
  MEDLINE   22086138
   PUBMED   11948177
  REMARK    GeneRIF: IQGAP1 has a crucial role in transducing Cdc42 signaling
            to the cytoskeleton
REFERENCE   18 (bases 1 to 7219)
  AUTHORS   Fukata,M., Watanabe,T., Noritake,J., Nakagawa,M., Yamaga,M.,
            Kuroda,S., Matsuura,Y., Iwamatsu,A., Perez,F. and Kaibuchi,K.
  TITLE     Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170
  JOURNAL   Cell 109 (7), 873-885 (2002)
  MEDLINE   22105478
   PUBMED   12110184
REFERENCE   19 (bases 1 to 7219)
  AUTHORS   Mateer,S.C., McDaniel,A.E., Nicolas,V., Habermacher,G.M., Lin,M.J.,
            Cromer,D.A., King,M.E. and Bloom,G.S.
  TITLE     The mechanism for regulation of the F-actin binding activity of
            IQGAP1 by calcium/calmodulin
  JOURNAL   J. Biol. Chem. 277 (14), 12324-12333 (2002)
  MEDLINE   21922845
   PUBMED   11809768
  REMARK    GeneRIF: The mechanism for regulation of the F-actin binding
            activity of IQGAP1 by calcium/calmodulin
REFERENCE   20 (bases 1 to 7219)
  AUTHORS   Briggs,M.W., Li,Z. and Sacks,D.B.
  TITLE     IQGAP1-mediated stimulation of transcriptional co-activation by
            beta-catenin is modulated by calmodulin
  JOURNAL   J. Biol. Chem. 277 (9), 7453-7465 (2002)
  MEDLINE   21850627
   PUBMED   11734550
  REMARK    GeneRIF: IQGAP1 enhances the function of beta-catenin in the
            nucleus and that calmodulin regulates this stimulation
REFERENCE   21 (bases 1 to 7219)
  AUTHORS   Sugimoto,N., Imoto,I., Fukuda,Y., Kurihara,N., Kuroda,S.,
            Tanigami,A., Kaibuchi,K., Kamiyama,R. and Inazawa,J.
  TITLE     IQGAP1, a negative regulator of cell-cell adhesion, is upregulated
            by gene amplification at 15q26 in gastric cancer cell lines HSC39
            and 40A
  JOURNAL   J. Hum. Genet. 46 (1), 21-25 (2001)
  MEDLINE   21183350
   PUBMED   11289714
REFERENCE   22 (bases 1 to 7219)
  AUTHORS   Hart,M.J., Callow,M.G., Souza,B. and Polakis,P.
  TITLE     IQGAP1, a calmodulin-binding protein with a rasGAP-related domain,
            is a potential effector for cdc42Hs
  JOURNAL   EMBO J. 15 (12), 2997-3005 (1996)
  MEDLINE   96272160
   PUBMED   8670801
REFERENCE   23
  AUTHORS   Weissbach,L., Settleman,J., Kalady,M.F., Snijders,A.J.,
            Murthy,A.E., Yan,Y.X. and Bernards,A.
  TITLE     Identification of a human rasGAP-related protein containing
            calmodulin-binding motifs
  JOURNAL   J. Biol. Chem. 269 (32), 20517-20521 (1994)
  MEDLINE   94327627
   PUBMED   8051149
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D29640.1, AI924000.1 and
            BC016714.1.
            On Jan 7, 2005 this sequence version replaced gi:32261305.
            
            Summary: This gene encodes a member of the IQGAP family. The
            protein contains four IQ domains, one calponin homology domain, one
            Ras-GAP domain and one WW domain. It interacts with components of
            the cytoskeleton, with cell adhesion molecules, and with several
            signaling molecules to regulate cell morphology and motility.
            Expression of the protein is upregulated by gene amplification in
            two gastric cancer cell lines.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..7219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..7219
                     /gene="IQGAP1"
                     /note="synonyms: SAR1, p195, KIAA0051, HUMORFA01"
                     /db_xref="GeneID:8826"
                     /db_xref="MIM:603379"
     CDS             102..5075
                     /gene="IQGAP1"
                     /note="IQGAP1 protein; RasGAP-like with IQ motifs;
                     go_component: actin filament [goid 0005884] [evidence TAS]
                     [pmid 8670801];
                     go_function: calmodulin binding [goid 0005516] [evidence
                     TAS] [pmid 8670801];
                     go_function: GTPase inhibitor activity [goid 0005095]
                     [evidence TAS] [pmid 8670801];
                     go_function: Ras GTPase activator activity [goid 0005099]
                     [evidence IEA];
                     go_process: signal transduction [goid 0007165] [evidence
                     TAS] [pmid 8051149];
                     go_process: small GTPase mediated signal transduction
                     [goid 0007264] [evidence IEA]"
                     /codon_start=1
                     /product="IQ motif containing GTPase activating protein 1"
                     /protein_id="NP_003861.1"
                     /db_xref="GI:4506787"
                     /db_xref="GeneID:8826"
                     /db_xref="MIM:603379"
                     /translation="MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYL
                     CHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTR
                     YKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLF
                     KLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALH
                     AAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNR
                     TENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALG
                     LRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAV
                     ALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
                     SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQA
                     HAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAA
                     KLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFA
                     LGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNN
                     SKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQ
                     LWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDR
                     LAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYK
                     TLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
                     IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY
                     QHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTAL
                     QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK
                     TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFL
                     SAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPD
                     AFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKF
                     RRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
                     NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAE
                     MDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPD
                     KMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRR
                     YRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMK
                     GKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGV
                     QMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK"
     polyA_signal    6497..6502
                     /gene="IQGAP1"
     polyA_site      6522
                     /gene="IQGAP1"
                     /evidence=experimental
     polyA_signal    7187..7192
                     /gene="IQGAP1"
     polyA_site      7210
                     /gene="IQGAP1"
ORIGIN      
        1 ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa
       61 ggtttcacgg cttcctcagc agagactcgg gctcgtccgc catgtccgcc gcagacgagg
      121 ttgacgggct gggcgtggcc cggccgcact atggctctgt cctggataat gaaagactta
      181 ctgcagagga gatggatgaa aggagacgtc agaacgtggc ttatgagtac ctttgtcatt
      241 tggaagaagc gaagaggtgg atggaagcat gcctagggga agatctgcct cccaccacag
      301 aactggagga ggggcttagg aatggggtct accttgccaa actggggaac ttcttctctc
      361 ccaaagtagt gtccctgaaa aaaatctatg atcgagaaca gaccagatac aaggcgactg
      421 gcctccactt tagacacact gataatgtga ttcagtggtt gaatgccatg gatgagattg
      481 gattgcctaa gattttttac ccagaaacta cagatatcta tgatcgaaag aacatgccaa
      541 gatgtatcta ctgtatccat gcactcagtt tgtacctgtt caagctaggc ctggcccctc
      601 agattcaaga cctatatgga aaggttgact tcacagaaga agaaatcaac aacatgaaga
      661 ctgagttgga gaagtatggc atccagatgc ctgcctttag caagattggg ggcatcttgg
      721 ctaatgaact gtcagtggat gaagccgcat tacatgctgc tgttattgct attaatgaag
      781 ctattgaccg tagaattcca gccgacacat ttgcagcttt gaaaaatccg aatgccatgc
      841 ttgtaaatct tgaagagccc ttggcatcca cttaccagga tatactttac caggctaagc
      901 aggacaaaat gacaaatgct aaaaacagga cagaaaactc agagagagaa agagatgttt
      961 atgaggagct gctcacgcaa gctgaaattc aaggcaatat aaacaaagtc aatacatttt
     1021 ctgcattagc aaatatcgac ctggctttag aacaaggaga tgcactggcc ttgttcaggg
     1081 ctctgcagtc accagccctg gggcttcgag gactgcagca acagaatagc gactggtact
     1141 tgaagcagct cctgagtgat aaacagcaga agagacagag tggtcagact gaccccctgc
     1201 agaaggagga gctgcagtct ggagtggatg ctgcaaacag tgctgcccag caatatcaga
     1261 gaagattggc agcagtagca ctgattaatg ctgcaatcca gaagggtgtt gctgagaaga
     1321 ctgttttgga actgatgaat cccgaagccc agctgcccca ggtgtatcca tttgccgccg
     1381 atctctatca gaaggagctg gctaccctgc agcgacaaag tcctgaacat aatctcaccc
     1441 acccagagct ctctgtcgca gtggagatgt tgtcatcggt ggccctgatc aacagggcat
     1501 tggaatcagg agatgtgaat acagtgtgga agcaattgag cagttcagtt actggtctta
     1561 ccaatattga ggaagaaaac tgtcagaggt atctcgatga gttgatgaaa ctgaaggctc
     1621 aggcacatgc agagaataat gaattcatta catggaatga tatccaagct tgcgtggacc
     1681 atgtgaacct ggtggtgcaa gaggaacatg agaggatttt agccattggt ttaattaatg
     1741 aagccctgga tgaaggtgat gcccaaaaga ctctgcaggc cctacagatt cctgcagcta
     1801 aacttgaggg agtccttgca gaagtggccc agcattacca agacacgctg attagagcga
     1861 agagagagaa agcccaggaa atccaggatg agtcagctgt gttatggttg gatgaaattc
     1921 aaggtggaat ctggcagtcc aacaaagaca cccaagaagc acagaagttt gccttaggaa
     1981 tctttgccat taatgaggca gtagaaagtg gtgatgttgg caaaacactg agtgcccttc
     2041 gctcccctga tgttggcttg tatggagtca tccctgagtg tggtgaaact taccacagtg
     2101 atcttgctga agccaagaag aaaaaactgg cagtaggaga taataacagc aagtgggtga
     2161 agcactgggt aaaaggtgga tattattatt accacaatct ggagacccag gaaggaggat
     2221 gggatgaacc tccaaatttt gtgcaaaatt ctatgcagct ttctcgggag gagatccaga
     2281 gttctatctc tggggtgact gccgcatata accgagaaca gctgtggctg gccaatgaag
     2341 gcctgatcac caggctgcag gctcgctgcc gtggatactt agttcgacag gaattccgat
     2401 ccaggatgaa tttcctgaag aaacaaatcc ctgccatcac ctgcattcag tcacagtgga
     2461 gaggatacaa gcagaagaag gcatatcaag atcggttagc ttacctgcgc tcccacaaag
     2521 atgaagttgt aaagattcag tccctggcaa ggatgcacca agctcgaaag cgctatcgag
     2581 atcgcctgca gtacttccgg gaccatataa atgacattat caaaatccag gcttttattc
     2641 gggcaaacaa agctcgggat gactacaaga ctctcatcaa tgctgaggat cctcctatgg
     2701 ttgtggtccg aaaatttgtc cacctgctgg accaaagtga ccaggatttt caggaggagc
     2761 ttgaccttat gaagatgcgg gaagaggtta tcaccctcat tcgttctaac cagcagctgg
     2821 agaatgacct caatctcatg gatatcaaaa ttggactgct agtgaaaaat aagattacgt
     2881 tgcaggatgt ggtttcccac agtaaaaaac ttaccaaaaa aaataaggaa cagttgtctg
     2941 atatgatgat gataaataaa cagaagggag gtctcaaggc tttgagcaag gagaagagag
     3001 agaagttgga agcttaccag cacctgtttt atttattgca aaccaatccc acctatctgg
     3061 ccaagctcat ttttcagatg ccccagaaca agtccaccaa gttcatggac tctgtaatct
     3121 tcacactcta caactacgcg tccaaccagc gagaggagta cctgctcctg cggctcttta
     3181 agacagcact ccaagaggaa atcaagtcga aggtagatca gattcaagag attgtgacag
     3241 gaaatcctac ggttattaaa atggttgtaa gtttcaaccg tggtgcccgt ggccagaatg
     3301 ccctgagaca gatcttggcc ccagtcgtga aggaaattat ggatgacaaa tctctcaaca
     3361 tcaaaactga ccctgtggat atttacaaat cttgggttaa tcagatggag tctcagacag
     3421 gagaggcaag caaactgccc tatgatgtga cccctgagca ggcgctagct catgaagaag
     3481 tgaagacacg gctagacagc tccatcagga acatgcgggc tgtgacagac aagtttctct
     3541 cagccattgt cagctctgtg gacaaaatcc cttatgggat gcgcttcatt gccaaagtgc
     3601 tgaaggactc gttgcatgag aagttccctg atgctggtga ggatgagctg ctgaagatta
     3661 ttggtaactt gctttattat cgatacatga atccagccat tgttgctcct gatgcctttg
     3721 acatcattga cctgtcagca ggaggccagc ttaccacaga ccaacgccga aatctgggct
     3781 ccattgcaaa aatgcttcag catgctgctt ccaataagat gtttctggga gataatgccc
     3841 acttaagcat cattaatgaa tatctttccc agtcctacca gaaattcaga cggtttttcc
     3901 aaactgcttg tgatgtccca gagcttcagg ataaatttaa tgtggatgag tactctgatt
     3961 tagtaaccct caccaaacca gtaatctaca tttccattgg tgaaatcatc aacacccaca
     4021 ctctcctgtt ggatcaccag gatgccattg ctccggagca caatgatcca atccacgaac
     4081 tgctggacga cctcggcgag gtgcccacca tcgagtccct gataggggaa agctctggca
     4141 atttaaatga cccaaataag gaggcactgg ctaagacgga agtgtctctc accctgacca
     4201 acaagttcga cgtgcctgga gatgagaatg cagaaatgga tgctcgaacc atcttactga
     4261 atacaaaacg tttaattgtg gatgtcatcc ggttccagcc aggagagacc ttgactgaaa
     4321 tcctagaaac accagccacc agtgaacagg aagcagaaca tcagagagcc atgcagagac
     4381 gtgctatccg tgatgccaaa acacctgaca agatgaaaaa gtcaaaatct gtaaaggaag
     4441 acagcaacct cactcttcaa gagaagaaag agaagatcca gacaggttta aagaagctaa
     4501 cagagcttgg aaccgtggac ccaaagaaca aataccagga actgatcaac gacattgcca
     4561 gggatattcg gaatcagcgg aggtaccgac agaggagaaa ggccgaacta gtgaaactgc
     4621 aacagacata cgctgctctg aactctaagg ccacctttta tggggagcag gtggattact
     4681 ataaaagcta tatcaaaacc tgcttggata acttagccag caagggcaaa gtctccaaaa
     4741 agcctaggga aatgaaagga aagaaaagca aaaagatttc tctgaaatat acagcagcaa
     4801 gactacatga aaaaggagtt cttctggaaa ttgaggacct gcaagtgaat cagtttaaaa
     4861 atgttatatt tgaaatcagt ccaacagaag aagttggaga cttcgaagtg aaagccaaat
     4921 tcatgggagt tcaaatggag acttttatgt tacattatca ggacctgctg cagctacagt
     4981 atgaaggagt tgcagtcatg aaattatttg atagagctaa agtaaatgtc aacctcctga
     5041 tcttccttct caacaaaaag ttctacggga agtaattgat cgtttgctgc cagcccagaa
     5101 ggatgaagga aagaagcacc tcacagctcc tttctaggtc cttctttcct cattggaagc
     5161 aaagacctag ccaacaacag cacctcaatc tgatacactc ccgatgccac atttttaact
     5221 cctctcgctc tgatgggaca tttgttaccc ttttttcata gtgaaattgt gtttcaggct
     5281 tagtctgacc tttctggttt cttcattttc ttccattact taggaaagag tggaaactcc
     5341 actaaaattt ctctgtgttg ttacagtctt agaggttgca gtactatatt gtaagctttg
     5401 gtgtttgttt aattagcaat agggatggta ggattcaaat gtgtgtcatt tagaagtgga
     5461 agctattagc accaatgaca taaatacata caagacacac aactaaaatg tcatgttatt
     5521 aacagttatt aggttgtcat ttaaaaataa agttccttta tatttctgtc ccatcaggaa
     5581 aactgaagga tatggggaat cattggttat cttccattgt gtttttcttt atggacagga
     5641 gctaatggaa gtgacagtca tgttcaaagg aagcatttct agaaaaaagg agataatgtt
     5701 tttaaatttc attatcaaac ttgggcaatt ctgtttgtgt aactccccga ctagtggatg
     5761 ggagagtccc attgctaaaa ttcagctact cagataaatt cagaatgggt caaggcacct
     5821 gcctgttttt gttggtgcac agagattgac ttgattcaga gagacaattc actccatccc
     5881 tatggcagag gaatgggtta gccctaatgt agaatgtcat tgtttttaaa actgttttat
     5941 atcttaagag tgccttatta aagtatagat gtatgtctta aaatgtgggt gataggaatt
     6001 ttaaagattt atataatgca tcaaaagcct tagaataaga aaagcttttt ttaaattgct
     6061 ttatctgtat atctgaactc ttgaaactta tagctaaaac actaggattt atctgcagtg
     6121 ttcagggaga taattctgcc tttaattgtc taaaacaaaa acaaaaccag ccaacctatg
     6181 ttacacgtga gattaaaacc aattttttcc ccattttttc tccttttttc tcttgctgcc
     6241 cacattgtgc ctttatttta tgagccccag ttttctgggc ttagtttaaa aaaaaaatca
     6301 agtctaaaca ttgcatttag aaagcttttg ttcttggata aaaagtcata cactttaaaa
     6361 aaaaaaaaaa ctttttccag gaaaatatat tgaaatcatg ctgctgagcc tctattttct
     6421 ttctttgatg ttttgattca gtattctttt atcataaatt tttagcattt aaaaattcac
     6481 tgatgtacat taagccaata aactgcttta atgaataaca aactatgtag tgtgtcccta
     6541 ttataaatgc attggagaag tatttttatg agactcttta ctcaggtgca tggttacagc
     6601 ccacagggag gcatggagtg ccatggaagg attcgccact acccagacct tgttttttgt
     6661 tgtattttgg aagacaggtt ttttaaagaa acattttcct cagattaaaa gatgatgcta
     6721 ttacaactag cattgcctca aaaactggga ccaaccaaag tgtgtcaacc ctgtttcctt
     6781 aaaagaggct atgaatccca aaggccacat ccaagacagg caataatgag cagagtttac
     6841 agctccttta ataaaatgtg tcagtaattt taaggtttat agttccctca acacaattgc
     6901 taatgcagaa tagtgtaaaa tgcgcttcaa gaatgttgat gatgatgata tagaattgtg
     6961 gctttagtag cacagaggat gccccaacaa actcatggcg ttgaaaccac acagttctca
     7021 ttactgttat ttattagctg tagcattctc tgtctcctct ctctcctcct ttgaccttct
     7081 cctcgaccag ccatcatgac atttaccatg aatttacttc ctcccaagag tttggactgc
     7141 ccgtcagatt gttgctgcac atagttgcct ttgtatctct gtatgaaata aaaggtcatt
     7201 tgttcatgtt aaaaaaaaa
//

LOCUS       NM_003909               4868 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens copine III (CPNE3), mRNA.
ACCESSION   NM_003909
VERSION     NM_003909.2  GI:41872597
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4868)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J. Leukoc. Biol. 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   2  (bases 1 to 4868)
  AUTHORS   Caudell,E.G., Caudell,J.J., Tang,C.H., Yu,T.K., Frederick,M.J. and
            Grimm,E.A.
  TITLE     Characterization of human copine III as a phosphoprotein with
            associated kinase activity
  JOURNAL   Biochemistry 39 (42), 13034-13043 (2000)
   PUBMED   11041869
REFERENCE   3  (bases 1 to 4868)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J. Biol. Chem. 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008385.1, AB014536.1,
            BC036242.1, AF116654.1, BM014699.1, BC015734.1 and AI031907.1.
            On Feb 3, 2004 this sequence version replaced gi:4503014.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm.  Copine III contains two type II C2 domains in the
            amino-terminus and an A domain-like sequence in the
            carboxy-terminus.  The A domain mediates interactions between
            integrins and extracellular ligands.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..4868
                     /gene="CPNE3"
                     /note="synonyms: CPN3, PRO1071, KIAA0636"
                     /db_xref="GeneID:8895"
                     /db_xref="MIM:604207"
     CDS             148..1761
                     /gene="CPNE3"
                     /note="go_component: cytosol [goid 0005829] [evidence IDA]
                     [pmid 12949241];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: transporter activity [goid 0005215] [evidence
                     TAS] [pmid 9430674];
                     go_function: calcium-dependent phospholipid binding [goid
                     0005544] [evidence TAS] [pmid 11041869];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence IDA] [pmid 11041869];
                     go_process: lipid metabolism [goid 0006629] [evidence TAS]
                     [pmid 9430674];
                     go_process: vesicle-mediated transport [goid 0016192]
                     [evidence TAS] [pmid 9430674]"
                     /codon_start=1
                     /product="copine III"
                     /protein_id="NP_003900.1"
                     /db_xref="GI:4503015"
                     /db_xref="GeneID:8895"
                     /db_xref="MIM:604207"
                     /translation="MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYE
                     VERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTL
                     GQIVSSKKLTRPLVMKTGRPAGKGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSD
                     PYLEFHKQTSDGNWLMVHRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYD
                     NDGSHDLIGTFQTTMTKLKEASRSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITV
                     ECTFLDYIMGGCQLNFTVGVDFTGSNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQ
                     DYDADKMFPAFGFGAQIPPQWQVSHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLY
                     GPTNFSPIINHVARFAAAATQQQTASQYFVLLIITDGVITDLDETRQAIVNASRLPMS
                     IIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAIRDIVQFVPFRQFQNAPKEALAQCVL
                     AEIPQQVVGYFNTYKLLPPKNPATKQQKQ"
     polyA_site      4764
                     /gene="CPNE3"
                     /evidence=experimental
     polyA_signal    4825..4830
                     /gene="CPNE3"
     polyA_site      4843
                     /gene="CPNE3"
                     /evidence=experimental
     polyA_site      4847
                     /gene="CPNE3"
                     /evidence=experimental
     polyA_site      4849
                     /gene="CPNE3"
                     /evidence=experimental
ORIGIN      
        1 agccctaggt tctcctgaat ccctgcggtc ccagcgtcgc tccggacgct gccaacctgt
       61 tctccaccgt cgctcgactt ccacctctaa gactcccacg aaactcaggt tgaataattc
      121 atcaaattac acaactgaac tcaagacatg gctgcccagt gtgtcacaaa ggtggcgctg
      181 aatgtttcct gtgccaatct tttggataaa gatatagggt caaagtcaga ccctttatgt
      241 gtgttgtttt tgaatacaag tggtcaacag tggtatgagg ttgagcgcac agaaaggatt
      301 aagaattgct tgaatcccca attttccaag acatttatta ttgattacta ctttgaagtg
      361 gttcagaaat tgaaatttgg ggtttatgac atcgacaaca aaactattga gctgagtgat
      421 gatgacttct taggggaatg tgaatgtacc cttggacaaa ttgtttccag caagaagcta
      481 actcgaccac tggtgatgaa aactggcaga cctgcaggaa aagggagcat tacgatttca
      541 gctgaagaaa taaaagataa tagagtggtc ttgtttgaaa tggaagccag aaaactggat
      601 aataaggatc tatttggaaa gtcagaccca tacctggaat tccacaagca gacatctgat
      661 ggaaactggc taatggttca tcggacagag gttgttaaaa acaacttgaa tcctgtttgg
      721 aggcctttca agatctctct taactcactg tgttacggag atatggacaa aaccattaag
      781 gtggagtgtt atgattatga caatgatggg tcacatgatc tcattggaac atttcagacc
      841 accatgacaa aactgaaaga agcctccaga agctcacctg ttgaatttga atgcataaat
      901 gagaaaaaaa ggcaaaagaa aaaaagctac aagaattcag gtgttatcag tgtgaaacag
      961 tgtgagatta cagtagaatg cacattcctt gactatataa tgggaggatg tcagctgaat
     1021 tttactgtgg gagtggactt cactggctcc aatggtgacc caaggtctcc agactccctt
     1081 cattacatca gccccaatgg cgttaatgag tatttgactg ctctctggtc tgtgggactg
     1141 gtcattcaag attatgatgc tgataagatg tttccagctt ttggttttgg cgctcagata
     1201 cctcctcagt ggcaggtatc acatgaattt ccaatgaact tcaacccatc caatccctac
     1261 tgcaatggaa tccaaggcat tgtagaggcg tatcggtctt gtcttcctca gataaaactc
     1321 tatggaccaa ctaatttttc tccaatcata aatcacgtgg ccaggtttgc tgctgcagcc
     1381 acgcaacagc agacagcttc tcaatatttt gtgcttttga ttattactga tggtgtgatc
     1441 acagaccttg atgaaaccag acaagctata gttaatgcct ccaggctgcc tatgtccatc
     1501 ataattgttg gagttggagg tgctgacttc agcgccatgg agtttctgga tggtgatggt
     1561 ggaagtctcc gctccccatt gggcgaagtg gccatcagag atattgtcca gtttgtgcct
     1621 ttcagacagt tccagaatgc tccaaaagaa gcacttgctc agtgtgtctt ggcagagatt
     1681 ccccagcagg tggtgggcta cttcaataca tacaaactcc ttcctcccaa gaacccagcc
     1741 acgaaacaac agaagcagtg accacttcaa cagaattctt ttgtgttatg tggagcaatg
     1801 ccatctctca ccccaaatcg tgtatctgtc attctacgta ctttttaccc ccagcattta
     1861 tgatgtaaat ctctttctct atggattata tctgtttaaa gcattctttc taggttattt
     1921 tggggggaca gtgccaagtc catctttgcc cagtcaattc agtgattgat agcaatttac
     1981 attaattgca gtaaagctct ttggattaga aattagtgtg gggaaagctt attctgttgt
     2041 tgtttttgtt tactttcata tgatgaaaat gctgtgttta agtgtttgtc aataggaaga
     2101 atggaaaact gttgggatga tgtggtttgc aggttgctgt gcctgattca cagtgtatgt
     2161 tgtataagcc aatgtccata cctgattatg agagcttctt aaattatatg atatcaaatt
     2221 tgttcctgta actctgtata cagtgctttt ctgcaaggta aaaataacct gtctatgcat
     2281 ctgatttttg ctacagttta gacactgtgg tttacaaaac agcatgcact caacttggga
     2341 ctttatgaaa agtactgaat gagcaggaaa aggcacatac tcagtttttt aaatgtacaa
     2401 tcaacaagta aaaataacct catgtaagta agccattttt atttgccttt ctagatattt
     2461 tattttattg tggaaaactg taaacatggt cagatttggc tttttttttc attaactgag
     2521 caagactttc aggatattgt agatgcacag atggtaggtt gtcctgaatt ctacattatt
     2581 agattacttt aattgagatt tgttaaaacg gttaggactg ttttgtccag gaaagataag
     2641 aggaccaaac atataaggtg aaattcagaa ttccgtttcc ttctaactaa tgaaaaactg
     2701 cttactaaaa aaaaatttta tactttcctt gctaaggtcc catatattga tttgtacaga
     2761 tccacttagt cattttctcc tttttttaag aaccattttc atctgatttt taaactcacg
     2821 ataccagtta tctgttaatc aaaattgcat tttacaattt aataatgtga tatttcctat
     2881 gtctacagca taccttatta ggtataaaac ctactgcaac ttagaaaaag gaaagaaaaa
     2941 agaaaacttt tccaactgct gcattaagat agggtggatt ttatgtgctt ttttttttta
     3001 agagttgaat ttcttttcct gacttttacc ttttacagcg tattacttag tgaacattac
     3061 attttcagaa tagatcctaa tattttattg agggcctatg tgctaaaaac tatgcatatc
     3121 tatatattgg ccaattatct ttaataattt accttttgaa attgcatgtt tatcatatat
     3181 ccttaagtgg acacatacag tgccatgttg atgtgcctct cagttttatt gaaaagctgc
     3241 cccacagccc atgtctcttg ttctctgcaa tgcctcaagg gagtgagctc tcaaccacag
     3301 atagctgtgg cttctcagaa gcagctcatt gccaaggcca ggctgagagg ggacctgctt
     3361 gctgtggtgg ttgcctagcc cagatgagca tttacctacc accttcccac ttggctagct
     3421 gtcctttgga tatgtgctgt taactgggga aggcatctaa ctagtagcct gctactccat
     3481 agtatggctc aatagatgac acatcatttt gacattatca ataggagaaa agaaaactaa
     3541 cccttcttct gattgtttgg agccatagtt gtctcagatg ttctaattct ctttgtatgc
     3601 ttggaaacag catagatatg ttgctgtggt tttcagaatt ttctctttta atcacaagaa
     3661 gccttttaaa aaatgactta cacatattct caatgtacag taaaacagac agaagtgagc
     3721 ttatctgttt gatgctgtgg cagggtccca gtcactgggc atatcctcct tctccttaac
     3781 cagctccaca gcagcccctg agtcacctgc acaaggtgct tgggaactgc tggttatgag
     3841 cattcctggt tttcttcagc caaataacag gtaatcactg tcaattggat ttggtcttca
     3901 ttattttata ttctgatttt atcagaatta ttctatttta aaattgtttt aaaatttaaa
     3961 acatttaatt catgatcatg ttcatcagta gatgctatta ttcataagaa ctgtgattcc
     4021 agcaaactag ggtaattggt gcctttttac agttttgaat aaaagcattt acaatttcta
     4081 aattatcagt tttcacagtt tcagcactca acctcatcat acgctgattt aatattgttt
     4141 tacattaaaa tagtcctttt ccctgttgtg ccaccattca tttaagtgct gtttgttctt
     4201 aaaatgcatt taaagaaaaa ttacccatat tgactttcac acctcatata atcagatcta
     4261 ttacaaatat atatcggagt gacggtgccc aggatagatg taatatttct tacagatgct
     4321 ggcacagagg aaataatata ccagctaatc tagtcaccta accttgtggt tagaattgca
     4381 attttaagac cagaaaaatt tgaagtctga tcagagattt acaactgttc attatagtgg
     4441 tgccttaggc aatctttcca aagtaaattc agggccccat tgctacttat gccatatttg
     4501 gacatacttt ttttttcttc aattttgtaa acttcctgga aagctgtctt cactaagtat
     4561 cccctagtct ctatatatgt ggttagtagt catggaaatg acacataaag tacgccagaa
     4621 gtttgatgga acgtgttaga aactgttttg tgcttttatg gatgtcatac ttgacaatac
     4681 atgtgtaagt tactaatata tgaattgatg ctaaatatat cttacatttg aattcctttt
     4741 ggataaagtt atttcttgat gtgacagagt agtgtgtttt catttttatt ctttacatgt
     4801 gaccaaaaca atagaaaagt taaaaataaa atatagtgtt ttaggtggca aaaaaaaaaa
     4861 aaaaaaaa
//

LOCUS       NM_003945                894 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e
            (ATP6V0E), mRNA.
ACCESSION   NM_003945
VERSION     NM_003945.3  GI:50593534
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Morel,N.
  TITLE     Neurotransmitter release: the dark side of the vacuolar-H+ATPase
  JOURNAL   Biol. Cell 95 (7), 453-457 (2003)
   PUBMED   14597263
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Smith,A.N., Lovering,R.C., Futai,M., Takeda,J., Brown,D. and
            Karet,F.E.
  TITLE     Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit
            genes
  JOURNAL   Mol. Cell 12 (4), 801-803 (2003)
   PUBMED   14580332
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Kawasaki-Nishi,S., Nishi,T. and Forgac,M.
  TITLE     Proton translocation driven by ATP hydrolysis in V-ATPases
  JOURNAL   FEBS Lett. 545 (1), 76-85 (2003)
   PUBMED   12788495
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Lu,M., Vergara,S., Zhang,L., Holliday,L.S., Aris,J. and Gluck,S.L.
  TITLE     The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase
            (V-ATPase) interacts with the H subunit and is required for
            V-ATPase function
  JOURNAL   J. Biol. Chem. 277 (41), 38409-38415 (2002)
   PUBMED   12163484
  REMARK    GeneRIF: Data demonstrate the physiological significance of the
            interaction between the E and H subunits of V-ATPase and extend
            previous studies on the arrangement of subunits on the peripheral
            stalk of V-ATPase.
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Nishi,T. and Forgac,M.
  TITLE     The vacuolar (H+)-ATPases--nature's most versatile proton pumps
  JOURNAL   Nat. Rev. Mol. Cell Biol. 3 (2), 94-103 (2002)
   PUBMED   11836511
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Wieczorek,H., Brown,D., Grinstein,S., Ehrenfeld,J. and Harvey,W.R.
  TITLE     Animal plasma membrane energization by proton-motive V-ATPases
  JOURNAL   Bioessays 21 (8), 637-648 (1999)
   PUBMED   10440860
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Forgac,M.
  TITLE     Structure and properties of the vacuolar (H+)-ATPases
  JOURNAL   J. Biol. Chem. 274 (19), 12951-12954 (1999)
   PUBMED   10224039
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Nelson,N. and Harvey,W.R.
  TITLE     Vacuolar and plasma membrane proton-adenosinetriphosphatases
  JOURNAL   Physiol. Rev. 79 (2), 361-385 (1999)
   PUBMED   10221984
REFERENCE   9  (bases 1 to 894)
  AUTHORS   Kane,P.M.
  TITLE     Introduction: V-ATPases 1992-1998
  JOURNAL   J. Bioenerg. Biomembr. 31 (1), 3-5 (1999)
   PUBMED   10340843
REFERENCE   10 (bases 1 to 894)
  AUTHORS   Ludwig,J., Kerscher,S., Brandt,U., Pfeiffer,K., Getlawi,F.,
            Apps,D.K. and Schagger,H.
  TITLE     Identification and characterization of a novel 9.2-kDa membrane
            sector-associated protein of vacuolar proton-ATPase from chromaffin
            granules
  JOURNAL   J. Biol. Chem. 273 (18), 10939-10947 (1998)
   PUBMED   9556572
REFERENCE   11 (bases 1 to 894)
  AUTHORS   Finbow,M.E. and Harrison,M.A.
  TITLE     The vacuolar H+-ATPase: a universal proton pump of eukaryotes
  JOURNAL   Biochem. J. 324 (Pt 3), 697-712 (1997)
   PUBMED   9210392
REFERENCE   12 (bases 1 to 894)
  AUTHORS   Stevens,T.H. and Forgac,M.
  TITLE     Structure, function and regulation of the vacuolar (H+)-ATPase
  JOURNAL   Annu. Rev. Cell Dev. Biol. 13, 779-808 (1997)
   PUBMED   9442887
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF691381.1, Y15286.1 and
            AI198465.1.
            On Jul 26, 2004 this sequence version replaced gi:19913435.
            
            Summary: This gene encodes a component of vacuolar ATPase
            (V-ATPase), a multisubunit enzyme that mediates acidification of
            eukaryotic intracellular organelles. V-ATPase dependent organelle
            acidification is necessary for such intracellular processes as
            protein sorting, zymogen activation, receptor-mediated endocytosis,
            and synaptic vesicle proton gradient generation. V-ATPase is
            composed of a cytosolic V1 domain and a transmembrane V0 domain.
            The V1 domain consists of three A and three B subunits, two G
            subunits plus the C, D, E, F, and H subunits. The V1 domain
            contains the ATP catalytic site. The V0 domain consists of five
            different subunits: a, c, c', c', and d. Additional isoforms of
            many of the V1 and V0 subunit proteins are encoded by multiple
            genes or alternatively spliced transcript variants. This encoded
            protein is possibly part of the V0 subunit. Since two
            nontranscribed pseudogenes have been found in dog, it is possible
            that the localization to chromosome 2 for this gene by radiation
            hybrid mapping is representing a pseudogene. Genomic mapping puts
            the chromosomal location on 5q35.3.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..894
                     /gene="ATP6V0E"
                     /note="synonyms: M9.2, ATP6H, Vma21, Vma21p"
                     /db_xref="GeneID:8992"
                     /db_xref="MIM:603931"
     CDS             102..347
                     /gene="ATP6V0E"
                     /EC_number="3.6.3.14"
                     /note="ATPase, H+ transporting, lysosomal 9kD V0 subunit
                     e; ATPase, H+ transporting, lysosomal (vacuolar proton
                     pump) 9kD; ATPase, H+ transporting, lysosomal 9kD V0
                     subunit M9.2; vacuolar ATP synthase subunit H; V-ATPase H
                     subunit; vacuolar proton pump H subunit; V-ATPase M9.2
                     subunit; V-ATPase 9.2 kDa membrane accessory protein;
                     H(+)-transporting two-sector ATPase, subunit H; vacuolar
                     proton-ATPase subunit M9.2; ATPase, H+ transporting,
                     lysosomal, 9kD;
                     go_component: membrane fraction [goid 0005624] [evidence
                     TAS] [pmid 9556572];
                     go_component: proton-transporting two-sector ATPase
                     complex [goid 0016469] [evidence IEA];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: transporter activity [goid 0005215] [evidence
                     NAS] [pmid 9556572];
                     go_function: hydrogen-transporting ATPase activity,
                     rotational mechanism [goid 0046961] [evidence TAS] [pmid
                     9556572];
                     go_function: hydrogen-transporting ATP synthase activity,
                     rotational mechanism [goid 0046933] [evidence IEA];
                     go_process: proton transport [goid 0015992] [evidence TAS]
                     [pmid 9556572];
                     go_process: ATP synthesis coupled proton transport [goid
                     0015986] [evidence IEA]"
                     /codon_start=1
                     /product="ATPase, H+ transporting, lysosomal, V0 subunit
                     e"
                     /protein_id="NP_003936.1"
                     /db_xref="GI:4502319"
                     /db_xref="GeneID:8992"
                     /db_xref="MIM:603931"
                     /translation="MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTC
                     SVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP"
     polyA_signal    849..854
                     /gene="ATP6V0E"
     polyA_site      882
                     /gene="ATP6V0E"
                     /evidence=experimental
ORIGIN      
        1 aggcggggct tgcacacgct ggtcacgcgg tcagctattg acacttcctg gtgggatccg
       61 agtgaggcga cggggtaggg gttggcgctc aggcggcgac catggcgtat cacggcctca
      121 ctgtgcctct cattgtgatg agcgtgttct ggggcttcgt cggcttcttg gtgccttggt
      181 tcatccctaa gggtcctaac cggggagtta tcattaccat gttggtgacc tgttcagttt
      241 gctgctatct cttttggctg attgcaattc tggcccaact caaccctctc tttggaccgc
      301 aattgaaaaa tgaaaccatc tggtatctga agtatcattg gccttgagga agaagacatg
      361 ctctacagtg ctcagtcttt gaggtcacga gaagagaatg ccttctagat gcaaaatcac
      421 ctccaaacca gaccactttt cttgacttgc ctgttttggc cattagctgc cttaaacgtt
      481 aacagcacat ttgaatgcct tattctacaa tgcagcgtgt tttcctttgc cttttttgca
      541 ctttggtgaa ttacgtgcct ccataacctg aactgtgccg actccacaaa acgattatgt
      601 actcttctga gatagaagat gctgttcttc tgagagatac gttactctct ccttggaatc
      661 tgtggatttg aagatggctc ctgccttctc acgtgggaat cagtgaagtg tttagaaact
      721 gctgcaagac aaacaagact ccagtggggt ggtcagtagg agagcacgtt cagagggaag
      781 agccatctca acagaatcgc accaaactat actttcagga tgaatttctt ctttctgcca
      841 tcttttggaa taaatatttt cctcctttct atggaaatct ggaaaaaaaa aaaa
//

LOCUS       NM_004099               3108 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens stomatin (STOM), transcript variant 1, mRNA.
ACCESSION   NM_004099
VERSION     NM_004099.4  GI:38016910
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3108)
  AUTHORS   Fricke,B., Argent,A.C., Chetty,M.C., Pizzey,A.R., Turner,E.J.,
            Ho,M.M., Iolascon,A., von,D. and Stewart,G.W.
  TITLE     The 'stomatin' gene and protein in overhydrated hereditary
            stomatocytosis
  JOURNAL   Blood 102 (6), 2268-2277 (2003)
  MEDLINE   22840643
   PUBMED   12750157
  REMARK    GeneRIF: in stomatocytosis there is no significant abnormality in
            stomatin gene sequence instead, deficiency of stomatin from red
            cells appears to be due to a loss of stomatin from these red cells
            on maturation in the bone marrow and in the circulation.
REFERENCE   2  (bases 1 to 3108)
  AUTHORS   Feuk-Lagerstedt,E., Samuelsson,M., Mosgoeller,W., Movitz,C.,
            Rosqvist,A., Bergstr, Larsson,T., Steiner,M., Prohaska,R. and
            Karlsson,A.
  TITLE     The presence of stomatin in detergent-insoluble domains of
            neutrophil granule membranes
  JOURNAL   J. Leukoc. Biol. 72 (5), 970-977 (2002)
  MEDLINE   22317133
   PUBMED   12429719
  REMARK    GeneRIF: stomatin is localized to detergent-insoluble domains of
            neutrophil granule membranes
REFERENCE   3  (bases 1 to 3108)
  AUTHORS   Mairhofer,M., Steiner,M., Mosgoeller,W., Prohaska,R. and Salzer,U.
  TITLE     Stomatin is a major lipid-raft component of platelet alpha granules
  JOURNAL   Blood 100 (3), 897-904 (2002)
  MEDLINE   22122444
   PUBMED   12130500
  REMARK    GeneRIF: This study demonstrated the existence of alpha-granular
            lipid rafts and suggests an important role for stomatin in the
            organization and function of alpha granules.
REFERENCE   4  (bases 1 to 3108)
  AUTHORS   Unfried,I., Entler,B. and Prohaska,R.
  TITLE     The organization of the gene (EPB72) encoding the human erythrocyte
            band 7 integral membrane protein (protein 7.2b)
  JOURNAL   Genomics 30 (3), 521-528 (1995)
  MEDLINE   96423038
   PUBMED   8825639
REFERENCE   5  (bases 1 to 3108)
  AUTHORS   Gallagher,P.G. and Forget,B.G.
  TITLE     Structure, organization, and expression of the human band 7.2b
            gene, a candidate gene for hereditary hydrocytosis
  JOURNAL   J. Biol. Chem. 270 (44), 26358-26363 (1995)
  MEDLINE   96064711
   PUBMED   7592848
REFERENCE   6  (bases 1 to 3108)
  AUTHORS   Westberg,J.A., Entler,B., Prohaska,R. and Schr.
  TITLE     The gene coding for erythrocyte protein band 7.2b (EPB72) is
            located in band q34.1 of human chromosome 9
  JOURNAL   Cytogenet. Cell Genet. 63 (4), 241-243 (1993)
  MEDLINE   93272568
   PUBMED   8500356
REFERENCE   7  (bases 1 to 3108)
  AUTHORS   Hiebl-Dirschmied,C.M., Entler,B., Glotzmann,C., Maurer-Fogy,I.,
            Stratowa,C. and Prohaska,R.
  TITLE     Cloning and nucleotide sequence of cDNA encoding human erythrocyte
            band 7 integral membrane protein
  JOURNAL   Biochim. Biophys. Acta 1090 (1), 123-124 (1991)
  MEDLINE   91355220
   PUBMED   1883838
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BM451470.1, M81635.1,
            AF130103.1, BC010703.1, BI763647.1 and AL040491.1.
            On Oct 29, 2003 this sequence version replaced gi:21361754.
FEATURES             Location/Qualifiers
     source          1..3108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.1"
     gene            1..3108
                     /gene="STOM"
                     /note="synonyms: BND7, EPB7, EPB72"
                     /db_xref="GeneID:2040"
                     /db_xref="MIM:133090"
     CDS             81..947
                     /gene="STOM"
                     /note="isoform a is encoded by transcript variant 1;
                     erythrocyte membrane protein band 7.2 (stomatin);
                     go_component: cytoskeleton [goid 0005856] [evidence TAS]
                     [pmid 7592848];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 7592848]"
                     /codon_start=1
                     /product="stomatin isoform a"
                     /protein_id="NP_004090.4"
                     /db_xref="GI:38016911"
                     /db_xref="GeneID:2040"
                     /db_xref="MIM:133090"
                     /translation="MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVI
                     TFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFD
                     IPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNL
                     SQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREAR
                     AKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDML
                     QGIIGAKHSHLG"
ORIGIN      
        1 gcctctggct cctcagggca ttcccggcgg ctccgggttt ggcaacgagg acgggggagt
       61 gcgactgcgt ctcgggcagc atggccgaga agcggcacac acgggactcc gaagcccagc
      121 ggctccccga ctccttcaag gacagcccca gtaagggcct tggaccttgc ggatggattt
      181 tggtggcgtt ctcattctta ttcaccgtta taactttccc aatctcaata tggatgtgca
      241 taaagattat aaaagagtat gaaagagcca tcatctttag attgggtcgc attttacaag
      301 gaggagccaa aggacctggt ttgtttttta ttctgccatg cactgacagc ttcatcaaag
      361 tggacatgag aactatttca tttgatattc ctcctcagga gatcctcaca aaggattcag
      421 tgacaattag cgtggatggt gtggtctatt accgcgttca gaatgcaacc ctggctgtgg
      481 caaatatcac caacgctgac tcagcaaccc gtcttttggc acaaactact ctgaggaatg
      541 ttctgggcac caagaatctt tctcagatcc tctctgacag agaagaaatt gcacacaaca
      601 tgcagtctac tctggatgat gccactgatg cctggggaat aaaggtggag cgtgtggaaa
      661 ttaaggatgt gaaactacct gtgcagctcc agagagctat ggctgcagaa gcagaagcgt
      721 cccgcgaggc ccgcgccaag gttattgcag ccgaaggaga aatgaatgca tccagggctc
      781 tgaaagaagc ctccatggtc atcactgaat ctcctgcagc ccttcagctc cgatacctgc
      841 agacactgac caccattgct gctgagaaaa actcaacaat tgtcttccct ctgcccatag
      901 atatgctgca aggaatcata ggggcaaaac acagccatct aggctagtgt agagatgagc
      961 gctagccttc caagcatgaa gtcggggacc aaattagcct ttaactcata aagagagggt
     1021 agggcttttc tttttccata tgtcaattgt ggtgttccca gaatgtatag cagttataaa
     1081 aataggtgaa agaattgtta gcttgtaaat actgagagat tggtgattta tataaggtaa
     1141 tctgttagtc ttaaaatagt taaaagtttg tatttttaga ttattatgta gtaggttaga
     1201 tccctcttgt tttgacttcc actgactcat tctgaacccc ctaagcaccc aggccagagg
     1261 caagaacctg ggctgtaact gccacctgac accgctgact ggctaaatgc tttgcagaaa
     1321 gtgatgacct tacaccacaa ccagcttctc caggtcatat gtgccttacc tccagagagt
     1381 cttttttttt ttttttctga gatggagttt cactcttgtt gcccaggctg gagtgcaata
     1441 gcatgatctc ggctcactgc aacctccgcc tcctgggttc aagagattct cctgcctcag
     1501 cctccccagt agctgggatt acaggctcat gccaccatgc ccagctaatt tttgtattat
     1561 tattattgtt ttttagtaga gacggggttt caccatgttg gccaggctag tcacgaactc
     1621 ctaacctcag gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc
     1681 taccacacct ggtttggaga gtcttaatta aggaaatttc cctaatgttc atttattttc
     1741 taaatccaga ccgtgtttca gaataatcct tacttgagag tagccatttt cttgcctgta
     1801 cttgtcagaa ctagaggaaa tagccaagac taatgaaaaa gattactcta acccttaaaa
     1861 gacttttaaa ttcactacta gagtggtcat tttaaaaata catccatgtt ttaacttatt
     1921 tgagccttct ttatgagtaa atgattcctc cttgttctgt ctttcaaacc agctaaatat
     1981 ttgtcacaaa agtgcttttt tctcactgtt gcctattttc atatatcagg ttttaaatag
     2041 ttttaatttt ttaataaaat tttctctacg ttctatatgc aattgttata tatctatttg
     2101 aatagctgaa ggactaaaat acttttttaa gagataactt caggaaacca ttatatttta
     2161 ctatctgcat gctgttaact gtggtacact gtgaaatatg ttgattacaa acccattcat
     2221 tacatagtat aaggaattca cagtatattg actatatagt gtctaatgat cttgggcaga
     2281 tactgtcaaa cttacaatat ctatatagat gtaggtcttt ttaaatttac ctagtcattc
     2341 ttctatcatg tatattgatg ctgaaagagg aactggtcag ctcctctgga caacaaattc
     2401 ttagtctata atattaggag acatcttctg ttttgcaaat gtctgtgaat ctgagcaacc
     2461 tggcattctg cttactggcc agaaagctgg cgggtgacat ttgtaacatt tcctctttga
     2521 gactctgagt tcacctagag aagtctaagc ataacagctt tctttcccag cacgagcctt
     2581 tatagctctc tttagctcaa ccactctgtc catccagcca atggatgtcc cttcccctgt
     2641 accccaattt caagcttatt ttaggaagcc ttgaactacc atgtatcctg gctcctagct
     2701 gagtttatta gaggtatgga gcagtgcaac ttaaactcaa gttgcactta cattttgaat
     2761 tttaaaatga tggttttatc tgttgtgtga agtggttcac ccttgaggac caggagcctc
     2821 catatcctga ctgaaaacct tttctgagac ttagagtaac agtgcttttg gttccttgag
     2881 ttctcctgtc tccagatacc aaatgacctt gacttttctg ccttgtgaat tcgtagtcca
     2941 atcagctgaa attaaatcac ttgggaggga cgcatagaag gagctctagg aacacagtgc
     3001 cagtgcagaa gtttctccag gtggcctccc tttccaacaa tgtacataat aaagtgtatg
     3061 cactttcact aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_004125               1470 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens guanine nucleotide binding protein (G protein), gamma
            10 (GNG10), mRNA.
ACCESSION   NM_004125
VERSION     NM_004125.2  GI:21361096
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Ray,K., Kunsch,C., Bonner,L.M. and Robishaw,J.D.
  TITLE     Isolation of cDNA clones encoding eight different human G protein
            gamma subunits, including three novel forms designated the gamma 4,
            gamma 10, and gamma 11 subunits
  JOURNAL   J. Biol. Chem. 270 (37), 21765-21771 (1995)
  MEDLINE   95394940
   PUBMED   7665596
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC015391.1.
            On Jun 10, 2002 this sequence version replaced gi:4758445.
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..1470
                     /gene="GNG10"
                     /db_xref="GeneID:2790"
                     /db_xref="MIM:604389"
     CDS             23..484
                     /gene="GNG10"
                     /note="guanine nucleotide binding protein 10; bA16L21.2.1;
                     go_component: heterotrimeric G-protein complex [goid
                     0005834] [evidence IEA];
                     go_function: GTPase activity [goid 0003924] [evidence TAS]
                     [pmid 7665596];
                     go_function: unfolded protein binding [goid 0051082]
                     [evidence IEA];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IEA];
                     go_process: protein folding [goid 0006457] [evidence IEA];
                     go_process: signal transduction [goid 0007165] [evidence
                     TAS] [pmid 7665596];
                     go_process: G-protein coupled receptor protein signaling
                     pathway [goid 0007186] [evidence IEA]"
                     /codon_start=1
                     /product="guanine nucleotide binding protein (G protein),
                     gamma 10"
                     /protein_id="NP_004116.2"
                     /db_xref="GI:21361097"
                     /db_xref="GeneID:2790"
                     /db_xref="MIM:604389"
                     /translation="MGAPLLSPGWGAGAAGRRWWMLLAPLLPALLLVRPAGALVEGLY
                     CGTRDCYEVLGVSRSAGKAEIARAYRQLARRYHPDRYRPQPGDEGPGRTPQSAEEAFL
                     LVATAYETLKVSQAAAELQQYCMQNACKDALLVGVPAGSNPFREPRSCALL"
ORIGIN      
        1 agagccgcca gcgaggctgg ggatgggggc gccgctgctc tctcccggct ggggagccgg
       61 ggctgccggc cggcgctggt ggatgctgct ggcgcccctg ctgccggcgc tgctgctggt
      121 gcggcccgcg ggggccctgg tggaggggct ctactgcggc acgcgggact gctacgaggt
      181 gctgggcgtg agccgctcgg cgggcaaggc ggagatcgcg cgggcctacc gccagctggc
      241 ccggcgctac caccctgacc gctaccggcc ccagcccgga gacgagggcc ccgggcggac
      301 gccgcagagc gccgaggagg ctttcctgct ggtggcaacc gcctacgaga cactcaaggt
      361 ctctcaggca gctgcagagc ttcaacagta ctgtatgcag aatgcctgca aggatgccct
      421 gctggtgggt gttccagctg gaagtaaccc cttccgggag cctagatcct gtgctttact
      481 ctgaagactc gagagaagtt tgctgaggaa tgccttcaag cacaaagtga tgaatgactg
      541 ccttcaagtc tcaagaaaac acttttccct aacttttaga gatatttcag ccctttcctg
      601 tggcctggtc ctatagccaa aatcacagat attcatgagt ttctacttga gtgagaaaac
      661 tgggtgaagg aatagaattt taaatagtaa taactgcttg ttttttttgt gcaagtactt
      721 ttatacataa gataaacaaa aaccttacca ccaaacatac caaaatgcac ctctttcata
      781 agtgagttac taagatttct atacctggaa tatcatgtat gtttcattta ctggatgttt
      841 acattttagg aaggaaaata gttttgttta tttaaacaac tgaatactta taaactgttg
      901 ttcctggaag ttatttattc cataaaaaat ttgttctttt gtcatgaatt tataattcct
      961 aaatgaagac cagaaagtac aaattgctgg gaggaagaat aggctttatt aatcaactga
     1021 tgtcttgatt tttctaaatg ggaagattgc tttattttta acactaatta tgggagcaga
     1081 ttcttagcaa acttctttgg aaaagttaat gttatgatgt gcattaggct gccccatcgt
     1141 gtatataaat gaagcagatt tgatttttgt attcttacgt ttctctgctt tgtagttgtg
     1201 gctgtactta aagaaataca gaatttcata tatttaaaaa tgtttaaaat gtgacccaca
     1261 gaacattgta aatgattaaa aactaacatg aaaatattac aacctaaaag aattcttaac
     1321 ttcacaagtg ttttacttcg acgatgtgcc tttgatttaa tttgggacac ttttttagaa
     1381 ggatacatta ttcgtgtttg caacggtctt tgaagagctt ggaaataaaa tttctgctta
     1441 attaatcaaa aaaaaaaaaa aaaaaaaaaa
//

LOCUS       NM_004239               6452 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.
ACCESSION   NM_004239
VERSION     NM_004239.1  GI:10863904
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6452)
  AUTHORS   Pernet-Gallay,K., Antony,C., Johannes,L., Bornens,M., Goud,B. and
            Rios,R.M.
  TITLE     The overexpression of GMAP-210 blocks anterograde and retrograde
            transport between the ER and the Golgi apparatus
  JOURNAL   Traffic 3 (11), 822-832 (2002)
   PUBMED   12383348
  REMARK    GeneRIF: The overexpression of this protein blocks anterograde and
            retrograde transport between the endoplasmic reticulum and the
            Golgi apparatus.
REFERENCE   2
  AUTHORS   Infante,C., Ramos-Morales,F., Fedriani,C., Bornens,M. and Rios,R.M.
  TITLE     GMAP-210, A cis-Golgi network-associated protein, is a minus end
            microtubule-binding protein
  JOURNAL   J. Cell Biol. 145 (1), 83-98 (1999)
   PUBMED   10189370
REFERENCE   3  (bases 1 to 6452)
  AUTHORS   Abe,A., Emi,N., Tanimoto,M., Terasaki,H., Marunouchi,T. and
            Saito,H.
  TITLE     Fusion of the platelet-derived growth factor receptor beta to a
            novel gene CEV14 in acute myelogenous leukemia after clonal
            evolution
  JOURNAL   Blood 90 (11), 4271-4277 (1997)
   PUBMED   9373237
REFERENCE   4  (bases 1 to 6452)
  AUTHORS   Chang,K.H., Chen,Y., Chen,T.T., Chou,W.H., Chen,P.L., Ma,Y.Y.,
            Yang-Feng,T.L., Leng,X., Tsai,M.J., O'Malley,B.W. and Lee,W.H.
  TITLE     A thyroid hormone receptor coactivator negatively regulated by the
            retinoblastoma protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (17), 9040-9045 (1997)
   PUBMED   9256431
REFERENCE   5  (bases 1 to 6452)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol. Endocrinol. 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y12490.1.
            
            Summary: TRIP11 was first identified through its ability to
            interact functionally with thyroid hormone receptor-beta (THRB; MIM
            190160). It has also been found in association with the Golgi
            apparatus and microtubules.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..6452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31-q32"
     gene            1..6452
                     /gene="TRIP11"
                     /note="synonyms: CEV14, TRIP230, GMAP-210"
                     /db_xref="GeneID:9321"
                     /db_xref="MIM:604505"
     CDS             357..6296
                     /gene="TRIP11"
                     /note="thyroid receptor interacting protein 11;
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     IEA];
                     go_function: protein binding [goid 0005515] [evidence TAS]
                     [pmid 9256431];
                     go_function: transcription coactivator activity [goid
                     0003713] [evidence TAS] [pmid 9256431];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence TAS] [pmid 9256431]"
                     /codon_start=1
                     /product="thyroid hormone receptor interactor 11"
                     /protein_id="NP_004230.1"
                     /db_xref="GI:10863905"
                     /db_xref="GeneID:9321"
                     /db_xref="MIM:604505"
                     /translation="MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEE
                     VEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ
                     KEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD
                     DMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNII
                     KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGG
                     SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR
                     EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ
                     ALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN
                     EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEAT
                     KHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQ
                     SEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR
                     NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL
                     VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE
                     KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS
                     SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLG
                     SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKH
                     HQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI
                     EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL
                     EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQ
                     QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTR
                     FESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQF
                     EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSK
                     LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS
                     LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIA
                     ATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE
                     NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR
                     EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA
                     LKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLR
                     KKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQ
                     YALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA
                     NAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM
                     RNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGSVTRWMTGWLGGGSKS
                     VPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTN
                     APESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTF
                     TPLPALPDNSAGVVLKDLLKQ"
     polyA_signal    6427..6432
                     /gene="TRIP11"
ORIGIN      
        1 cgagcgagtg tcatggcggc cggcgtcgag ttggcaggag taacccacgg aactgaggaa
       61 agtcattaga gctgagaaag aagtggccca atctggacgg tgggaattcg tgggaatgag
      121 cagaaggccc tccgtagtga ctgtgtcact agaggcgggc ccctggtaaa attccaggcc
      181 aggcctctgc gtttctaggc agaacctgga gtcggccttg cctgagaacc cagctttgtg
      241 ttatcgtatc ctgtctcgcg aaggcaggcg ttcaaggata tttggtcgga tcgcccggcg
      301 gcgctaaacg ttttcttttt tccgagcgga ccgggtcgtt ctctaaactc gccgcgatgt
      361 cgtcctggct tgggggcctc ggctccggat tgggccagtc tctgggtcaa gtcgggggca
      421 gcctggcttc cctcactggc cagatatcaa actttacaaa ggatatgctg atggagggca
      481 cggaggaagt ggaagcagaa ttacctgatt ctaggacaaa ggaaattgaa gccattcatg
      541 caatcttgag atcagagaat gaaaggctta agaaactttg tactgatcta gaagagaaac
      601 atgaagcatc agagattcaa ataaagcagc aatctacaag ttaccgaaat caacttcaac
      661 aaaaagaggt agaaatcagc catcttaaag ccagacagat tgcactccag gatcagttgc
      721 tgaaactgca gtcagctgct cagtcagtac cttcaggagc tggtgtacca gcaaccactg
      781 catcatcttc attcgcttat gggattagtc atcatccttc agctttccat gacgatgaca
      841 tggactttgg tgatataatt tcatcccaac aagaaataaa ccgactctca aatgaagttt
      901 caagacttga gtctgaagtt ggccattgga ggcatattgc tcagacttcc aaagcacaag
      961 gaacagataa ctctgatcaa agtgaaatat gtaaactaca aaatatcatt aaggaactaa
     1021 aacagaaccg aagtcaggaa attgatgacc atcaacatga aatgtcagta ctgcagaatg
     1081 cacaccaaca gaaattgaca gaaataagtc gacgacatcg agaagaatta agtgactatg
     1141 aagaacgaat tgaagaactt gaaaatctgt tacaacaagg tggctctgga gttatagaaa
     1201 ctgatctctc taaaatctat gagatgcaaa aaactattca agttctacaa atagaaaaag
     1261 tggagtctac caaaaaaatg gaacaacttg aggataaaat aaaagatata aataaaaaat
     1321 tatcttctgc agaaaatgac agagatattt tgaggaggga acaagaacag ctaaatgtgg
     1381 aaaagagaca aataatggaa gaatgtgaaa acttgaaatt ggaatgtagt aaattgcagc
     1441 cttctgctgt gaagcaaagt gatactatga cagaaaagga aagaattctt gcccagagtg
     1501 catcagtgga agaagtgttc agactacaac aagcactgtc tgatgccgaa aatgaaataa
     1561 tgagattgag tagtttaaac caggataaca gtcttgctga agacaatctg aaacttaaaa
     1621 tgcgtatcga agttttagaa aaagagaagt cattactgag tcaagaaaag gaagaacttc
     1681 agatgtcact tttaaaattg aacaatgaat atgaagtaat taaaagtaca gctacaagag
     1741 acataagttt ggattcagaa ttacatgact taagacttaa tttggaggca aaggaacaag
     1801 aactcaatca gagtattagt gaaaaggaaa cactgatagc tgagatagaa gaattggaca
     1861 gacagaatca agaagctaca aagcacatga ttttgataaa agatcagcta tcaaaacaac
     1921 aaaatgaagg agatagcatc atcagtaaac tgaaacaaga tctaaatgat gaaaaaaaga
     1981 gagttcatca acttgaagat gataaaatgg acattactaa agagttagat gtacagaaag
     2041 aaaagctaat tcaaagtgaa gtggccctaa atgatttaca tttaaccaag cagaaacttg
     2101 aggacaaagt agaaaattta gtagatcagc taaataaatc acaagaaagt aatgtaagca
     2161 tccagaagga gaatttagaa cttaaggagc atattagaca aaatgaggag gagctttcta
     2221 gaataaggaa tgagttaatg cagtctctaa atcaagactc taatagtaat tttaaggata
     2281 ccttacttaa agaaagagaa gctgaagtta gaaacttaaa gcaaaatctt tcagaattag
     2341 aacagctcaa tgaaaattta aagaaagttg cttttgatgt caaaatggaa aatgaaaagt
     2401 tagttttagc atgtgaagat gtgaggcatc agttagaaga atgtcttgct ggtaacaatc
     2461 agctttctct ggaaaaaaac actattgtgg agactctaaa aatggaaaaa ggagagatag
     2521 aggcagaatt gtgttgggct aaaaagaggc tgttggaaga agcaaacaag tatgagaaaa
     2581 ccattgaaga actgtcaaat gcacgtaatt tgaatacctc tgccttacag ctggaacatg
     2641 agcatttaat taaactcaat caaaagaaag acatggaaat agcagaactc aaaaagaata
     2701 ttgaacaaat ggatactgac cataaagaaa ctaaggacgt tttgtcatct agtttagaag
     2761 agcagaagca gttgacacaa cttataaaca agaaagaaat ttttattgaa aagcttaaag
     2821 aaagaagttc aaagctgcag gaggaattgg ataaatattc tcaggcctta agaaaaaatg
     2881 aaattttaag acagaccata gaggaaaaag accgaagtct tggatccatg aaagaggaaa
     2941 ataatcatct gcaagaagaa ttggaacgac tcagggaaga gcagagtcga accgcacctg
     3001 tggctgaccc taaaaccctt gatagtgtta ctgaactagc atctgaggta tctcaactga
     3061 acacgatcaa ggaacatctt gaagaggaaa ttaaacatca tcaaaagata attgaagatc
     3121 aaaaccagag taagatgcaa ctacttcagt ctttacaaga gcaaaagaag gaaatggatg
     3181 agtttagata ccagcatgag caaatgaacg ccacacacac ccagctcttt ttagagaagg
     3241 atgaggaaat taagagtttg caaaaaacaa ttgaacaaat caaaacccag ttgcatgaag
     3301 aaagacagga cattcaaaca gataactctg atatttttca agaaacaaaa gttcagagcc
     3361 ttaatataga aaatggaagt gaaaagcatg atttatctaa agctgaaacg gaaagattag
     3421 tgaaaggaat aaaagagcga gaactggaga ttaaacttct aaatgaaaag aatatatctt
     3481 taactaaaca gattgatcag ttgtccaaag atgaagttgg taaactaact cagattattc
     3541 agcagaaaga tttggagata caagctcttc atgctagaat ttcttcaact tcccatactc
     3601 aagatgttgt ttaccttcaa cagcaactgc aggcttatgc tatggaaaga gaaaaggtat
     3661 ttgctgtttt gaatgagaag actagggaaa atagccatct aaaaacagaa tatcacaaaa
     3721 tgatggatat tgttgctgcc aaggaagcag ctcttatcaa actgcaagat gaaaataaaa
     3781 aattgtccac tagatttgaa agtagtggcc aagatatgtt tagagaaact attcagaatt
     3841 tatcacgtat cattcgagaa aaagacatcg aaatagatgc actaagtcag aaatgtcaga
     3901 ctttattggc agttttacaa acatccagca ctggtaatga ggctggaggt gttaatagtc
     3961 atcaatttga ggagcttcta caggaacgtg acaagttaaa acagcaagta aagaaaatgg
     4021 aagagtggaa gcagcaggtg atgaccacag tacaaaatat gcaacacgag tcagcccagc
     4081 ttcaggaaga gcttcaccaa cttcaagcac aggttttggt tgacagtgat aataattcta
     4141 aattacaagt ggactatact ggcctgatcc aaagttatga gcagaatgaa accaaactca
     4201 aaaattttgg gcaggaatta gcacaagttc agcacagcat tgggcagctt tgcaatacca
     4261 aggatcttct tttaggaaaa cttgatatta tttcacccca gctgtcttct gcatcattgc
     4321 ttactcccca gtctgcagag tgtcttagag caagtaagtc tgaagtattg agtgaatctt
     4381 ctgaattgct tcagcaagag ttagaagagc taagaaaatc actacaggaa aaagatgcaa
     4441 caattagaac tctccaggaa aataaccaca gattgtctga ttcgattgct gccacctcag
     4501 agctagaaag aaaagaacac gaacaaaccg attcagaaat caagcagcta aaggagaaac
     4561 aagatgtttt gcaaaagtta cttaaggaaa aagacctctt aatcaaagcc aaaagtgatc
     4621 aactactttc ttccaatgaa aatttcacta acaaagtaaa tgaaaacgaa cttttgaggc
     4681 aggcagtaac aaacctgaag gagagaatat taattctaga gatggacatt ggcaaactaa
     4741 aaggagaaaa tgaaaaaata gtggaaacat acaggggaaa ggaaacagaa tatcaagcgt
     4801 tacaagagac taacatgaag ttttctatga tgctgcgaga aaaagagttt gagtgccact
     4861 caatgaagga gaaggctctt gcttttgaac agctattgaa agagaaagaa cagggcaaga
     4921 ctggagagtt aaatcagctt ttaaatgcag ttaaatcaat gcaggagaag acagttgtgt
     4981 ttcaacagga gagagaccaa gtcatgttgg ccctgaaaca aaaacaaatg gaaaatactg
     5041 ccctacagaa tgaggttcaa cgtttacgtg acaaagaatt tcgttcaaac caagagctag
     5101 agagattgcg taatcatctt ttagaatcag aagattctta tacccgtgaa gctttggctg
     5161 cagaagatag agaggctaaa ctaagaaaga aagtcacagt attggaggaa aagctagttt
     5221 catcctctaa tgcaatggaa aatgcaagcc atcaagccag tgtgcaggta gagtcattgc
     5281 aagaacagtt gaatgtagtt tccaagcaaa gggatgaaac tgcgctgcag ctttctgtct
     5341 ctcaggaaca agtaaagcag tatgctctgt cactggccaa cctgcagatg gtactagagc
     5401 atttccaaca agaggaaaaa gctatgtatt ctgctgaact cgaaaagcaa aaacagctta
     5461 tagctgaatg gaagaaaaac gcagaaaatc tggaaggaaa agtgatatca ttacaggaat
     5521 gtttggatga agcaaatgct gcattggatt cagcatcaag acttacagaa cagttagatg
     5581 taaaagaaga acaaattgaa gaacttaaaa gacaaaatga gctccgacaa gaaatgctgg
     5641 atgatgtaca aaagaaattg atgagcttag caaacagctc agaaggaaaa gtagacaaag
     5701 tcctaatgag aaacctcttc attggtcatt tccacacacc gaaaaatcag cgtcatgaag
     5761 tgttacggtt aatggggagc atcctgggcg tcagaaggga ggagatggag cagttgtttc
     5821 atgacgatca gggcagtgtt accaggtgga tgactgggtg gcttggagga ggatcaaaaa
     5881 gtgttcccaa cacacctttg agaccaaatc agcaatctgt ggttaatagt tctttttcag
     5941 aactttttgt taaatttcta gaaacagaat ctcatccatc cattccacca ccaaagcttt
     6001 ctgttcatga tatgaaacct ctggattcac caggaagaag aaaaagagat acaaatgcac
     6061 cagaaagttt taaagataca gcagaatcca ggtctggtag aagaacagat gtaaatccgt
     6121 ttttggctcc tcgctcggca gctgtacctc ttattaaccc agctggactt ggacctggtg
     6181 ggcccgggca tcttcttctg aaacccatct cagatgtttt gcccacattt acacctttgc
     6241 cagcgttacc tgacaacagt gctggggttg tgctgaaaga ccttttaaag caatagatga
     6301 ttctcaagcc agagacaatc tagcacttta aagaaaccat gaacactata tgtatgtact
     6361 ttatcacaaa gtggcctttg gggagaaagt catgtatttg ttcgcaatta tgctttctct
     6421 gaatttaata aaaatattcc taatgctttt ag
//

LOCUS       NM_004339               2737 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens pituitary tumor-transforming 1 interacting protein
            (PTTG1IP), mRNA.
ACCESSION   NM_004339
VERSION     NM_004339.2  GI:11038670
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Tfelt-Hansen,J., Yano,S., Bandyopadhyay,S., Carroll,R., Brown,E.M.
            and Chattopadhyay,N.
  TITLE     Expression of pituitary tumor transforming gene (PTTG) and its
            binding protein in human astrocytes and astrocytoma cells: function
            and regulation of PTTG in U87 astrocytoma cells
  JOURNAL   Endocrinology 145 (9), 4222-4231 (2004)
   PUBMED   15178645
  REMARK    GeneRIF: PTTG expression was higher in malignant cells than in
            primary astrocytes, whereas PTTG-binding factor was not in
            astrocytoma
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Chien,W. and Pei,L.
  TITLE     A novel binding factor facilitates nuclear translocation and
            transcriptional activation function of the pituitary
            tumor-transforming gene product
  JOURNAL   J. Biol. Chem. 275 (25), 19422-19427 (2000)
   PUBMED   10781616
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Yaspo,M.L., Aaltonen,J., Horelli-Kuitunen,N., Peltonen,L. and
            Lehrach,H.
  TITLE     Cloning of a novel human putative type Ia integral membrane protein
            mapping to 21q22.3
  JOURNAL   Genomics 49 (1), 133-136 (1998)
   PUBMED   9570958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z50022.1 and AF149785.1.
            On Oct 30, 2000 this sequence version replaced gi:4757885.
            
            Summary: The encoded protein, which directly binds to pituitary
            tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear
            translocation of PTTG1 and potentiates the transcriptional
            activation of basic fibroblast growth factor by PTTG1. The gene
            product localizes to both the cytoplasm and nucleus. Its NLS is
            required for its own nuclear localization, the nuclear localization
            of PTTG1, and its interaction with PTTG1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2737
                     /gene="PTTG1IP"
                     /note="synonyms: PBF, C21orf1, C21orf3"
                     /db_xref="GeneID:754"
                     /db_xref="MIM:603784"
     CDS             211..753
                     /gene="PTTG1IP"
                     /note="pituitary tumor-transforming gene protein-binding
                     factor; PTTG-binding factor;
                     go_component: nucleus [goid 0005634] [evidence IDA] [pmid
                     10781616];
                     go_component: cytoplasm [goid 0005737] [evidence IDA]
                     [pmid 10781616];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: molecular_function unknown [goid 0005554]
                     [evidence ND];
                     go_process: protein-nucleus import [goid 0006606]
                     [evidence IDA] [pmid 10781616]"
                     /codon_start=1
                     /product="pituitary tumor-transforming gene 1
                     protein-interacting protein precursor"
                     /protein_id="NP_004330.1"
                     /db_xref="GI:4757886"
                     /db_xref="GeneID:754"
                     /db_xref="MIM:603784"
                     /translation="MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNT
                     NKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITM
                     SVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDE
                     IRKKYGLFKEENPYARFENN"
     sig_peptide     211..306
                     /gene="PTTG1IP"
     mat_peptide     307..750
                     /gene="PTTG1IP"
                     /product="pituitary tumor-transforming protein
                     1-interacting protein"
     misc_feature    658..708
                     /gene="PTTG1IP"
                     /note="Region: bipartite nuclear localization sequence"
                     /evidence=experimental
     polyA_signal    2716..2721
                     /gene="PTTG1IP"
                     /evidence=experimental
     polyA_site      2736
                     /gene="PTTG1IP"
                     /evidence=experimental
ORIGIN      
        1 ctgaacctca gccgcgccgg gaggcgagcc cgttggcgag gggcggggca gatggcgagg
       61 gagcggggcg agctgctttt tgaggctgcg cactcgcatg gccccacctc gcaggtccac
      121 ttccggcgcc gcggctgttc cgggcggaga ccgcttgtgc tggagtcgga gttgtaacgc
      181 tccactgact gatagagcga ccggccgacc atggcgcccg gagtggcccg cgggccgacg
      241 ccgtactgga ggttgcgcct cggtggcgcc gcgctgctcc tgctgctcat cccggtggcc
      301 gccgcgcagg agcctcccgg agctgcttgt tctcagaaca caaacaaaac ctgtgaagag
      361 tgcctgaaga acgtctcctg tctttggtgc aacactaaca aggcttgtct ggactaccca
      421 gttacaagcg tcttgccacc ggcttccctt tgtaaattga gctctgcacg ctggggagtt
      481 tgttgggtga actttgaggc gctgatcatc accatgtcgg tagtcggggg aaccctcctc
      541 ctgggcattg ccatctgctg ctgctgctgc tgcaggagga agaggagccg gaagccggac
      601 aggagtgagg agaaggccat gcgtgagcgg gaggagaggc ggatacggca ggaggaacgg
      661 agagcagaga tgaagacaag acatgatgaa atcagaaaaa aatatggcct gtttaaagaa
      721 gaaaacccgt atgctagatt tgaaaacaac taaagcgctc cagcacatca gtcccgacgc
      781 ttcctgtgag gtgcacgctc cgcagcccag cccagccggg agaccacgtg gccattgcgg
      841 tctcctgacc ttggccagtg aacctgccag ccttccagga caggcggccg gagagctgcc
      901 cctgaaggac agtcctctcg tcttgcagac tggtgacctt ctattccctg ttcatctctg
      961 tttctagatt tagtcacttg aaataagaaa tctttggggt ttgggctttt ttatactctt
     1021 ctcagtttgt gaaacgctaa ctgcacacga agccgcctga cggcacccag cgctgtggct
     1081 gtcattctcc cagggcagaa ccctgcgttt ctctctgtcc actaacaagc ttcacacgca
     1141 acacagggaa gtcggtttga cttttgtcat gaggagaact gaccagccct catcattccc
     1201 cataaaacca cggacagcgt ctgtgtgcgc atcttgagtc ttcacacctg ttgactcaca
     1261 cggcttttgc tgatgacacg gggctccagt acacagtctg ataaggactt aacgtcctaa
     1321 cctcaattgt attaaatagc attggggaat agctaaacct ttttaaaaaa atttattgga
     1381 ttttcctccc tgcttaaaag atttcaccag aaaaccttca tataaaaatt caggcccttt
     1441 ttggacaatt tttaaaattt gtatctttac tagaacatga gaatcttttt cccttggaag
     1501 cttgaattat aaatgtggtg tttggcctgc ctcagcagca ccagttgact gctcgtgtgc
     1561 cagcggtgtg gggaggacgg ggcaggacgc tgcagctctc tccagccctg ttggcatcct
     1621 cagtgcctgc aggcctctcg ctgcctgttg ggctgtctgg ggggtggcca tttagggatc
     1681 gtggggacgg ggtccacccc aagaagaaag aaaggcccgt ccacaggccc ggctctgggc
     1741 cacgtgcccc ggaagcaggt gtgtccagag tcagctgagg gctctcccca caccacccag
     1801 caggcgctgg tgctccttct gcctcatggg accagtccag cttccagccg ctctggctcg
     1861 agggtggtct gagcacttcc ttctgagtgg gcttctctgg gagctctcca gtggcactgc
     1921 tggacctgcc cacgtttctg taaaatcagg atacgtggct ttagtaagca gaccaagcgc
     1981 ttcgtggcag ggaaagcagc gtgcggggaa gtcactgaaa agtgctgcct aaggaagttt
     2041 ggaaatagtc cccgttccag attgccttga attttaaaac attttgcttt gggaaagtag
     2101 gtcagcagca cctaagatca aggatgcgtt ccattttcac acttcacagt catgaaaact
     2161 gagaagactg tcttcagcgt gaactaaagt tcacaggcag atcactgatc cagaacactt
     2221 caagaactcg tcaaacagct cgataagcct ttttgactgt gtacatctgt accgggaata
     2281 acattcctag gctgaaattt ccacaaagaa tagaacctgt acccagttct tcaggctgat
     2341 ttccctgacc tcttgggcat ttgtatttgt agtaaagtat tgcagagatt cctaagtatt
     2401 ttatagcagc catcaaaatt ggactttgta ttgtttattc ataaaagaca cttggtaata
     2461 gacttcagtg aactctgtat gaatgcagta gtgtgcgtgc aaaatccgct tcctgagcgt
     2521 agggtgctga gctggcgcta gggctcggtt gtgaaataca gcgtagtcag cccttgcgct
     2581 cagtgtagaa acccacgtct gtaaggtcgg tcttcgtcca tctgcttttt tctgaaatac
     2641 actaagagca gccacaaaac tgtaacctca aggaaaccat aaagcttgga gtgccttaat
     2701 ttttaaccag tttccaataa aacggtttac tacctga
//

LOCUS       NM_004364               2385 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA),
            mRNA.
ACCESSION   NM_004364
VERSION     NM_004364.2  GI:28872793
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Zhu,Q.S., Qian,B. and Levy,D.
  TITLE     CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates
            transcription of the human microsomal epoxide hydrolase gene
            (EPHX1) through the interaction with DNA-bound NF-Y
  JOURNAL   J. Biol. Chem. 279 (29), 29902-29910 (2004)
   PUBMED   15150264
  REMARK    GeneRIF: CCAAT/enhancer-binding protein alpha (C/EBPalpha)
            activates transcription of the human microsomal epoxide hydrolase
            gene (EPHX1) through the interaction with DNA-bound NF-Y
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Wu,F.Y., Wang,S.E., Chen,H., Wang,L., Hayward,S.D. and Hayward,G.S.
  TITLE     CCAAT/enhancer binding protein alpha binds to the Epstein-Barr
            virus (EBV) ZTA protein through oligomeric interactions and
            contributes to cooperative transcriptional activation of the ZTA
            promoter through direct binding to the ZII and ZIIIB motifs during
            induction of the EBV lytic cycle
  JOURNAL   J. Virol. 78 (9), 4847-4865 (2004)
   PUBMED   15078966
  REMARK    GeneRIF: interacts with Epstein-Barar virus ZTA protein through
            oligomerization and transactivates ZTA promoter by binding ZII and
            ZIIIB motifs during lytic cycle induction
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Schwieger,M., Lohler,J., Fischer,M., Herwig,U., Tenen,D.G. and
            Stocking,C.
  TITLE     A dominant-negative mutant of C/EBPalpha, associated with acute
            myeloid leukemias, inhibits differentiation of myeloid and
            erythroid progenitors of man but not mouse
  JOURNAL   Blood 103 (7), 2744-2752 (2004)
   PUBMED   14656889
  REMARK    GeneRIF: Expression of mutated CEBPA in human CD34+ cord blood
            cells dramatically inhibited differentiation of both myeloid and
            erythroid lineages.
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Afink,G., Westermark,U.K., Lammerts,E. and Nister,M.
  TITLE     C/EBP is an essential component of PDGFRA transcription in MG-63
            cells
  JOURNAL   Biochem. Biophys. Res. Commun. 315 (2), 313-318 (2004)
   PUBMED   14766209
  REMARK    GeneRIF: C-EBP has an essential role in regulating PDGFRalpha
            expression
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Frohling,S., Schlenk,R.F., Stolze,I., Bihlmayr,J., Benner,A.,
            Kreitmeier,S., Tobis,K., Dohner,H. and Dohner,K.
  TITLE     CEBPA mutations in younger adults with acute myeloid leukemia and
            normal cytogenetics: prognostic relevance and analysis of
            cooperating mutations
  JOURNAL   J. Clin. Oncol. 22 (4), 624-633 (2004)
   PUBMED   14726504
  REMARK    GeneRIF: Mutant CEBPA predicts favorable prognosis and may improve
            risk stratification in acute myeloid leukemia patients with normal
            cytogenetics.
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Cleaves,R., Wang,Q.F. and Friedman,A.D.
  TITLE     C/EBPalphap30, a myeloid leukemia oncoprotein, limits G-CSF
            receptor expression but not terminal granulopoiesis via
            site-selective inhibition of C/EBP DNA binding
  JOURNAL   Oncogene 23 (3), 716-725 (2004)
   PUBMED   14737106
  REMARK    GeneRIF: selective inhibition of G-CSF receptor expression by
            C/EBPalphap30-ER is due in part to its variable affinity for C/EBP
            sites
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Ross,S.E., Radomska,H.S., Wu,B., Zhang,P., Winnay,J.N., Bajnok,L.,
            Wright,W.S., Schaufele,F., Tenen,D.G. and MacDougald,O.A.
  TITLE     Phosphorylation of C/EBPalpha inhibits granulopoiesis
  JOURNAL   Mol. Cell. Biol. 24 (2), 675-686 (2004)
   PUBMED   14701740
  REMARK    GeneRIF: phosphorylation induces conformational changes in C/EBP
            alpha, increasing the distance between the amino termini of
            C/EBPalpha dimers. This favors monocyte differentiation by blocking
            granulopoiesis.
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Tavor,S., Park,D.J., Gery,S., Vuong,P.T., Gombart,A.F. and
            Koeffler,H.P.
  TITLE     Restoration of C/EBPalpha expression in a BCR-ABL+ cell line
            induces terminal granulocytic differentiation
  JOURNAL   J. Biol. Chem. 278 (52), 52651-52659 (2003)
   PUBMED   14517214
  REMARK    GeneRIF: C/EBPalpha has a role in neutrophil differentiation
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Foka,P., Irvine,S.A., Kockar,F. and Ramji,D.P.
  TITLE     Interleukin-6 represses the transcription of the CCAAT/enhancer
            binding protein-alpha gene in hepatoma cells by inhibiting its
            ability to autoactivate the proximal promoter region
  JOURNAL   Nucleic Acids Res. 31 (23), 6722-6732 (2003)
   PUBMED   14627805
  REMARK    GeneRIF: a novel mechanism for IL-6-mediated repression of gene
            transcription that involves a reduction in C/EBPalpha-mediated
            activation
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   D'Alo',F., Johansen,L.M., Nelson,E.A., Radomska,H.S., Evans,E.K.,
            Zhang,P., Nerlov,C. and Tenen,D.G.
  TITLE     The amino terminal and E2F interaction domains are critical for
            C/EBP alpha-mediated induction of granulopoietic development of
            hematopoietic cells
  JOURNAL   Blood 102 (9), 3163-3171 (2003)
   PUBMED   12869508
  REMARK    GeneRIF: several regions of the C/EBP alpha protein are involved in
            inhibition of proliferative pathways in granulopoiesis
REFERENCE   11 (bases 1 to 2385)
  AUTHORS   Puig-Kroger,A., Sanchez-Elsner,T., Ruiz,N., Andreu,E.J.,
            Prosper,F., Jensen,U.B., Gil,J., Erickson,P., Drabkin,H., Groner,Y.
            and Corbi,A.L.
  TITLE     RUNX/AML and C/EBP factors regulate CD11a integrin expression in
            myeloid cells through overlapping regulatory elements
  JOURNAL   Blood 102 (9), 3252-3261 (2003)
   PUBMED   12855590
  REMARK    GeneRIF: C/EBP and RUNX/AML factors compete for binding to their
            respective cognate elements and bind to the CD11a promoter MS7
            sequence in a cell lineage- and differentiation-dependent manner.
REFERENCE   12 (bases 1 to 2385)
  AUTHORS   Heckman,C.A., Wheeler,M.A. and Boxer,L.M.
  TITLE     Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells
  JOURNAL   Oncogene 22 (39), 7891-7899 (2003)
   PUBMED   12970736
  REMARK    GeneRIF: We conclude that C/EBPalpha and C/EBPbeta contribute to
            the deregulated expression of Bcl-2 in t(14;18) lymphoma cells
REFERENCE   13 (bases 1 to 2385)
  AUTHORS   Wang,S.E., Wu,F.Y., Yu,Y. and Hayward,G.S.
  TITLE     CCAAT/enhancer-binding protein-alpha is induced during the early
            stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic
            cycle reactivation and together with the KSHV replication and
            transcription activator (RTA) cooperatively stimulates the viral
            RTA, MTA, and PAN promoters
  JOURNAL   J. Virol. 77 (17), 9590-9612 (2003)
   PUBMED   12915572
  REMARK    GeneRIF: CCAAT/enhancer-binding protein-alpha is induced during the
            early stages of Kaposi's sarcoma-associated herpesvirus lytic cycle
            reactivation
REFERENCE   14 (bases 1 to 2385)
  AUTHORS   Liu,H., Keefer,J.R., Wang,Q.F. and Friedman,A.D.
  TITLE     Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression
            and monocytic differentiation depend upon the C/EBPalpha basic
            region
  JOURNAL   Blood 101 (10), 3885-3892 (2003)
   PUBMED   12522006
  REMARK    GeneRIF: affects on JunB expression and monocyte differentiation
REFERENCE   15 (bases 1 to 2385)
  AUTHORS   Khanna-Gupta,A., Zibello,T., Sun,H., Gaines,P. and Berliner,N.
  TITLE     Chromatin immunoprecipitation (ChIP) studies indicate a role for
            CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and
            C/EBP epsilon) and CDP/cut in myeloid maturation-induced
            lactoferrin gene expression
  JOURNAL   Blood 101 (9), 3460-3468 (2003)
   PUBMED   12522000
  REMARK    GeneRIF: C/EBP alpha binds to the lactoferrin promoter in
            nonexpressing cells.
REFERENCE   16 (bases 1 to 2385)
  AUTHORS   Milde-Langosch,K., Loning,T. and Bamberger,A.M.
  TITLE     Expression of the CCAAT/enhancer-binding proteins C/EBPalpha,
            C/EBPbeta and C/EBPdelta in breast cancer: correlations with
            clinicopathologic parameters and cell-cycle regulatory proteins
  JOURNAL   Breast Cancer Res. Treat. 79 (2), 175-185 (2003)
   PUBMED   12825852
  REMARK    GeneRIF: Expression levels of both C/EBPalpha isoforms in breast
            tumors were correlated with clinicopathological tumor parameters,
            expression of estrogen and progesterone receptors (ER, PR), Ki67
            immunostaining, and expression of 7 cell-cycle regulatory proteins.
REFERENCE   17 (bases 1 to 2385)
  AUTHORS   Rodriguez-Antona,C., Bort,R., Jover,R., Tindberg,N.,
            Ingelman-Sundberg,M., Gomez-Lechon,M.J. and Castell,J.V.
  TITLE     Transcriptional regulation of human CYP3A4 basal expression by
            CCAAT enhancer-binding protein alpha and hepatocyte nuclear
            factor-3 gamma
  JOURNAL   Mol. Pharmacol. 63 (5), 1180-1189 (2003)
   PUBMED   12695546
  REMARK    GeneRIF: C/EBP alpha and HNF-3 gamma cooperatively regulate CYP3A4
            expression in hepatic cells by a mechanism that probably involves
            chromatin remodeling.
REFERENCE   18 (bases 1 to 2385)
  AUTHORS   Snaddon,J., Smith,M.L., Neat,M., Cambal-Parrales,M.,
            Dixon-McIver,A., Arch,R., Amess,J.A., Rohatiner,A.Z., Lister,T.A.
            and Fitzgibbon,J.
  TITLE     Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
  JOURNAL   Genes Chromosomes Cancer 37 (1), 72-78 (2003)
   PUBMED   12661007
  REMARK    GeneRIF: Mutation of CEBPA is a recurrent finding in acute myeloid
            leukemia FAB type M1 and M2 and appears specific to the
            intermediate cytogenetic risk group patients.
REFERENCE   19 (bases 1 to 2385)
  AUTHORS   Subramanian,L., Benson,M.D. and Iniguez-Lluhi,J.A.
  TITLE     A synergy control motif within the attenuator domain of
            CCAAT/enhancer-binding protein alpha inhibits transcriptional
            synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3
  JOURNAL   J. Biol. Chem. 278 (11), 9134-9141 (2003)
   PUBMED   12511558
  REMARK    GeneRIF: CCAAT/enhancer-binding protein alpha has a synergy control
            motif that inhibits transcriptional synergy through its
            PIASy-enhanced modification by SUMO-1 or SUMO-3
REFERENCE   20 (bases 1 to 2385)
  AUTHORS   Shimokawa,T. and Ra,C.
  TITLE     C/EBP alpha and Ets protein family members regulate the human
            myeloid IgA Fc receptor (Fc alpha R, CD89) promoter
  JOURNAL   J. Immunol. 170 (5), 2564-2572 (2003)
   PUBMED   12594283
  REMARK    GeneRIF: C/EBP-alpha has been identified as a major activator of
            the human myeloid IgA Fc receptor promoter.
REFERENCE   21 (bases 1 to 2385)
  AUTHORS   Day,R.N., Voss,T.C., Enwright,J.F. III, Booker,C.F., Periasamy,A.
            and Schaufele,F.
  TITLE     Imaging the localized protein interactions between Pit-1 and the
            CCAAT/enhancer binding protein alpha in the living pituitary cell
            nucleus
  JOURNAL   Mol. Endocrinol. 17 (3), 333-345 (2003)
   PUBMED   12554785
  REMARK    GeneRIF: The intimate association of Pit-1 and C/EBPalpha at
            certain sites within the living cell nucleus could foster their
            combinatorial activities in the regulation of pituitary-specific
            gene expression.
REFERENCE   22 (bases 1 to 2385)
  AUTHORS   Brenner,S., Prosch,S., Schenke-Layland,K., Riese,U., Gausmann,U.
            and Platzer,C.
  TITLE     cAMP-induced Interleukin-10 promoter activation depends on
            CCAAT/enhancer-binding protein expression and monocytic
            differentiation
  JOURNAL   J. Biol. Chem. 278 (8), 5597-5604 (2003)
   PUBMED   12493739
  REMARK    GeneRIF: the level of basal as well as cAMP-stimulated IL-10
            transcription depends on the expression of C/EBP alpha and beta and
            their binding to three motifs in the promoter/enhancer region
REFERENCE   23 (bases 1 to 2385)
  AUTHORS   Truong,B.T., Lee,Y.J., Lodie,T.A., Park,D.J., Perrotti,D.,
            Watanabe,N., Koeffler,H.P., Nakajima,H., Tenen,D.G. and Kogan,S.C.
  TITLE     CCAAT/Enhancer binding proteins repress the leukemic phenotype of
            acute myeloid leukemia
  JOURNAL   Blood 101 (3), 1141-1148 (2003)
   PUBMED   12393450
  REMARK    GeneRIF: CEBPA and CEBPe repress the leukemic phenotype of acute
            myeloid leukemia, suppress cell growth, and induce partial
            differentiation.
REFERENCE   24 (bases 1 to 2385)
  AUTHORS   Kaeferstein,A., Krug,U., Tiesmeier,J., Aivado,M., Faulhaber,M.,
            Stadler,M., Krauter,J., Germing,U., Hofmann,W.K., Koeffler,H.P.,
            Ganser,A. and Verbeek,W.
  TITLE     The emergence of a C/EBPalpha mutation in the clonal evolution of
            MDS towards secondary AML
  JOURNAL   Leukemia 17 (2), 343-349 (2003)
   PUBMED   12592334
  REMARK    GeneRIF: The emergence of a mutation in this protein is involved in
            the clonal evolution of myelodysplastic syndromes towards secondary
            acute myeloid leukemia.
REFERENCE   25 (bases 1 to 2385)
  AUTHORS   Kumon,Y., Suehiro,T., Faulkes,D.J., Hosakawa,T., Ikeda,Y., Woo,P.,
            Sipe,J.D. and Hashimoto,K.
  TITLE     Transcriptional regulation of serum amyloid A1 gene expression in
            human aortic smooth muscle cells involves CCAAT/enhancer binding
            proteins (C/EBP) and is distinct from HepG2 cells
  JOURNAL   Scand. J. Immunol. 56 (5), 504-511 (2002)
   PUBMED   12410800
  REMARK    GeneRIF: 5'-region from -252 to -175, containing a consensus site
            for CCAAT/enhancer binding proteins alpha,beta (C/EBPalpha,beta),
            was essential for SAA1 induction in HASMCs.
REFERENCE   26 (bases 1 to 2385)
  AUTHORS   Preudhomme,C., Sagot,C., Boissel,N., Cayuela,J.M., Tigaud,I., de
            Botton,S., Thomas,X., Raffoux,E., Lamandin,C., Castaigne,S.,
            Fenaux,P. and Dombret,H.
  TITLE     Favorable prognostic significance of CEBPA mutations in patients
            with de novo acute myeloid leukemia: a study from the Acute
            Leukemia French Association (ALFA)
  JOURNAL   Blood 100 (8), 2717-2723 (2002)
   PUBMED   12351377
  REMARK    GeneRIF: favorable prognostic significance of mutations in patients
            with de novo acute myeloid leukemia
REFERENCE   27 (bases 1 to 2385)
  AUTHORS   Timchenko,L.T., Iakova,P., Welm,A.L., Cai,Z.J. and Timchenko,N.A.
  TITLE     Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and
            represses translation of C/EBP proteins
  JOURNAL   Mol. Cell. Biol. 22 (20), 7242-7257 (2002)
   PUBMED   12242300
  REMARK    GeneRIF: Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs
            and represses translation of C/EBP proteins.
REFERENCE   28 (bases 1 to 2385)
  AUTHORS   Efimova,T., Deucher,A., Kuroki,T., Ohba,M. and Eckert,R.L.
  TITLE     Novel protein kinase C isoforms regulate human keratinocyte
            differentiation by activating a p38 delta mitogen-activated protein
            kinase cascade that targets CCAAT/enhancer-binding protein alpha
  JOURNAL   J. Biol. Chem. 277 (35), 31753-31760 (2002)
   PUBMED   12080077
  REMARK    GeneRIF: Novel protein kinase C isoforms regulate human
            keratinocyte differentiation by activating a p38 delta
            mitogen-activated protein kinase cascade that targets this protein
REFERENCE   29 (bases 1 to 2385)
  AUTHORS   Wu,F.Y., Tang,Q.Q., Chen,H., ApRhys,C., Farrell,C., Chen,J.,
            Fujimuro,M., Lane,M.D. and Hayward,G.S.
  TITLE     Lytic replication-associated protein (RAP) encoded by Kaposi
            sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell
            cycle arrest through CCAAT/enhancer-binding protein-alpha
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (16), 10683-10688 (2002)
   PUBMED   12145325
  REMARK    GeneRIF: C/EBPalpha is essential for p21-mediated inhibition of G1
            to S-phase progression by RAP in KSHV-infected host cells
REFERENCE   30 (bases 1 to 2385)
  AUTHORS   Jurado,L.A., Song,S., Roesler,W.J. and Park,E.A.
  TITLE     Conserved amino acids within CCAAT enhancer-binding proteins
            (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase
            (PEPCK) gene expression
  JOURNAL   J. Biol. Chem. 277 (31), 27606-27612 (2002)
   PUBMED   11997389
  REMARK    GeneRIF: Conserved amino acids regulate phosphoenolpyruvate
            carboxykinase (PEPCK) gene expression.
REFERENCE   31 (bases 1 to 2385)
  AUTHORS   Behre,G., Singh,S.M., Liu,H., Bortolin,L.T., Christopeit,M.,
            Radomska,H.S., Rangatia,J., Hiddemann,W., Friedman,A.D. and
            Tenen,D.G.
  TITLE     Ras signaling enhances the activity of C/EBP alpha to induce
            granulocytic differentiation by phosphorylation of serine 248
  JOURNAL   J. Biol. Chem. 277 (29), 26293-26299 (2002)
   PUBMED   11978795
  REMARK    GeneRIF: Ras signaling enhances the activity of C/EBP alpha to
            induce granulocytic differentiation by phosphorylation of serine
            248.
REFERENCE   32 (bases 1 to 2385)
  AUTHORS   Reddy,V.A., Iwama,A., Iotzova,G., Schulz,M., Elsasser,A.,
            Vangala,R.K., Tenen,D.G., Hiddemann,W. and Behre,G.
  TITLE     Granulocyte inducer C/EBPalpha inactivates the myeloid master
            regulator PU.1: possible role in lineage commitment decisions
  JOURNAL   Blood 100 (2), 483-490 (2002)
   PUBMED   12091339
  REMARK    GeneRIF: C/EBPalpha and PU.1 interact physically and colocalize in
            myeloid cells, and C/EBPalpha blocks the function of PU.1.
REFERENCE   33 (bases 1 to 2385)
  AUTHORS   Zhang,P., Nelson,E., Radomska,H.S., Iwasaki-Arai,J., Akashi,K.,
            Friedman,A.D. and Tenen,D.G.
  TITLE     Induction of granulocytic differentiation by 2 pathways
  JOURNAL   Blood 99 (12), 4406-4412 (2002)
   PUBMED   12036869
  REMARK    GeneRIF: Conditional expression of C/EBP alpha induced the C/EBP
            family members C/EBP beta and C/EBP epsilon and subsequent
            granulocyte differentiation.
REFERENCE   34 (bases 1 to 2385)
  AUTHORS   Qiao,D., Im,E., Qi,W. and Martinez,J.D.
  TITLE     Activator protein-1 and CCAAT/enhancer-binding protein mediated
            GADD153 expression is involved in deoxycholic acid-induced
            apoptosis
  JOURNAL   Biochim. Biophys. Acta 1583 (1), 108-116 (2002)
   PUBMED   12069855
  REMARK    GeneRIF: role in mediating GADD153 expression is involved in
            deoxycholic acid-induced apoptosis
REFERENCE   35 (bases 1 to 2385)
  AUTHORS   Tomizawa,M., Wang,Y.Q., Ebara,M., Saisho,H., Watanabe,K.,
            Nakagawara,A. and Tagawa,M.
  TITLE     Decreased expression of the CCAAT/enhancer binding protein alpha
            gene involved in hepatocyte proliferation in human hepatocellular
            carcinomas
  JOURNAL   Int. J. Mol. Med. 9 (6), 597-600 (2002)
   PUBMED   12011976
  REMARK    GeneRIF: expression level of the C/EBPalpha gene in hepatocytes was
            downregulated in response to proliferation signals
REFERENCE   36 (bases 1 to 2385)
  AUTHORS   He,Y. and Crouch,E.
  TITLE     Surfactant protein D gene regulation. Interactions among the
            conserved CCAAT/enhancer-binding protein elements
  JOURNAL   J. Biol. Chem. 277 (22), 19530-19537 (2002)
   PUBMED   11912209
  REMARK    GeneRIF: Surfactant protein D gene regulation. Interactions among
            the conserved CCAAT/enhancer-binding protein elements.
REFERENCE   37 (bases 1 to 2385)
  AUTHORS   Gombart,A.F., Hofmann,W.K., Kawano,S., Takeuchi,S., Krug,U.,
            Kwok,S.H., Larsen,R.J., Asou,H., Miller,C.W., Hoelzer,D. and
            Koeffler,H.P.
  TITLE     Mutations in the gene encoding the transcription factor
            CCAAT/enhancer binding protein alpha in myelodysplastic syndromes
            and acute myeloid leukemias
  JOURNAL   Blood 99 (4), 1332-1340 (2002)
   PUBMED   11830484
  REMARK    GeneRIF: may function as a tumor suppressor that is mutated during
            tumorigenesis. Abnormalties in C/EBPalpha function contribute to
            the development of malignancies in a variety of tisues.
REFERENCE   38 (bases 1 to 2385)
  AUTHORS   Halmos,B., Huettner,C.S., Kocher,O., Ferenczi,K., Karp,D.D. and
            Tenen,D.G.
  TITLE     Down-regulation and antiproliferative role of C/EBPalpha in lung
            cancer
  JOURNAL   Cancer Res. 62 (2), 528-534 (2002)
   PUBMED   11809705
  REMARK    GeneRIF: Down-regulation and antiproliferative role of C/EBPalpha
            in lung cancer.
REFERENCE   39 (bases 1 to 2385)
  AUTHORS   Swart,G.W., van Groningen,J.J., van Ruissen,F., Bergers,M. and
            Schalkwijk,J.
  TITLE     Transcription factor C/EBPalpha: novel sites of expression and
            cloning of the human gene
  JOURNAL   Biol. Chem. 378 (5), 373-379 (1997)
   PUBMED   9191024
REFERENCE   40 (bases 1 to 2385)
  AUTHORS   Miller,S.G., De Vos,P., Guerre-Millo,M., Wong,K., Hermann,T.,
            Staels,B., Briggs,M.R. and Auwerx,J.
  TITLE     The adipocyte specific transcription factor C/EBPalpha modulates
            human ob gene expression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (11), 5507-5511 (1996)
   PUBMED   8643605
REFERENCE   41 (bases 1 to 2385)
  AUTHORS   Xu,L., Wan,D. and Liu,Y.
  TITLE     HP8: the partial cDNA clone of a novel member of C/EBP gene family
  JOURNAL   Zhonghua Yi Xue Za Zhi 76 (1), 20-23 (1996)
   PUBMED   8758458
REFERENCE   42 (bases 1 to 2385)
  AUTHORS   Antonson,P. and Xanthopoulos,K.G.
  TITLE     Molecular cloning, sequence, and expression patterns of the human
            gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)
  JOURNAL   Biochem. Biophys. Res. Commun. 215 (1), 106-113 (1995)
   PUBMED   7575576
REFERENCE   43 (bases 1 to 2385)
  AUTHORS   Hendricks-Taylor,L.R., Bachinski,L.L., Siciliano,M.J., Fertitta,A.,
            Trask,B., de Jong,P.J., Ledbetter,D.H. and Darlington,G.J.
  TITLE     The CCAAT/enhancer binding protein (C/EBP alpha) gene (CEBPA) maps
            to human chromosome 19q13.1 and the related nuclear factor NF-IL6
            (C/EBP beta) gene (CEBPB) maps to human chromosome 20q13.1
  JOURNAL   Genomics 14 (1), 12-17 (1992)
   PUBMED   1427819
REFERENCE   44 (bases 1 to 2385)
  AUTHORS   Szpirer,C., Riviere,M., Cortese,R., Nakamura,T., Islam,M.Q.,
            Levan,G. and Szpirer,J.
  TITLE     Chromosomal localization in man and rat of the genes encoding the
            liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1
            (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of
            the hepatocyte growth factor/scatter factor gene (HGF)
  JOURNAL   Genomics 13 (2), 293-300 (1992)
   PUBMED   1535333
REFERENCE   45 (bases 1 to 2385)
  AUTHORS   Cao,Z., Umek,R.M. and McKnight,S.L.
  TITLE     Regulated expression of three C/EBP isoforms during adipose
            conversion of 3T3-L1 cells
  JOURNAL   Genes Dev. 5 (9), 1538-1552 (1991)
   PUBMED   1840554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U34070.1.
            On Mar 6, 2003 this sequence version replaced gi:4757971.
            
            Summary: The protein encoded by this intronless gene is a bZIP
            transcription factor which can bind as a homodimer to certain
            promoters and enhancers. It can also form heterodimers with the
            related proteins CEBP-beta and CEBP-gamma. The encoded protein has
            been shown to bind to the promoter and modulate the expression of
            the gene encoding leptin, a protein that plays an important role in
            body weight homeostasis. Also, the encoded protein can interact
            with CDK2 and CDK4, thereby inhibiting these kinases and causing
            growth arrest in cultured cells.
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.1"
     gene            1..2385
                     /gene="CEBPA"
                     /note="synonyms: CEBP, C/EBP-alpha"
                     /db_xref="GeneID:1050"
                     /db_xref="MIM:116897"
     CDS             1..1077
                     /gene="CEBPA"
                     /note="go_component: nucleus [goid 0005634] [evidence NAS]
                     [pmid 7575576];
                     go_component: nucleus [goid 0005634] [evidence NAS] [pmid
                     8758458];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: RNA polymerase II transcription factor
                     activity, enhancer binding [goid 0003705] [evidence NAS]
                     [pmid 7575576];
                     go_function: RNA polymerase II transcription factor
                     activity, enhancer binding [goid 0003705] [evidence NAS]
                     [pmid 8758458];
                     go_process: transcription [goid 0006350] [evidence NAS]
                     [pmid 7575576];
                     go_process: transcription [goid 0006350] [evidence NAS]
                     [pmid 8758458];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="CCAAT/enhancer binding protein alpha"
                     /protein_id="NP_004355.2"
                     /db_xref="GI:28872794"
                     /db_xref="GeneID:1050"
                     /db_xref="MIM:116897"
                     /translation="MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPA
                     PPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGG
                     GGDFDYPGAPAGPGGAVMPGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVI
                     KQEPREEDEAKQLALAGLFPYQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTM
                     HLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAAHPDLRASGGSGAGKAKK
                     SVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRE
                     LDTLRGIFRQLPESSLVKAMGNCA"
ORIGIN      
        1 atggagtcgg ccgacttcta cgaggcggag ccgcggcccc cgatgagcag ccacctgcag
       61 agccccccgc acgcgcccag cagcgccgcc ttcggctttc cccggggcgc gggccccgcg
      121 cagcctcccg ccccacctgc cgccccggag ccgctgggcg gcatctgcga gcacgagacg
      181 tccatcgaca tcagcgccta catcgacccg gccgccttca acgacgagtt cctggccgac
      241 ctgttccagc acagccggca gcaggagaag gccaaggcgg ccgtgggccc cacgggcggc
      301 ggcggcggcg gcgactttga ctacccgggc gcgcccgcgg gccccggcgg cgccgtcatg
      361 cccgggggag cgcacgggcc cccgcccggc tacggctgcg cggccgccgg ctacctggac
      421 ggcaggctgg agcccctgta cgagcgcgtc ggggcgccgg cgctgcggcc gctggtgatc
      481 aagcaggagc cccgcgagga ggatgaagcc aagcagctgg cgctggccgg cctcttccct
      541 taccagccgc cgccgccgcc gccgccctcg cacccgcacc cgcacccgcc gcccgcgcac
      601 ctggccgccc cgcacctgca gttccagatc gcgcactgcg gccagaccac catgcacctg
      661 cagcccggtc accccacgcc gccgcccacg cccgtgccca gcccgcaccc cgcgcccgcg
      721 ctcggtgccg ccggcctgcc gggccctggc agcgcgctca aggggctggg cgccgcgcac
      781 cccgacctcc gcgcgagtgg cggcagcggc gcgggcaagg ccaagaagtc ggtggacaag
      841 aacagcaacg agtaccgggt gcggcgcgag cgcaacaaca tcgcggtgcg caagagccgc
      901 gacaaggcca agcagcgcaa cgtggagacg cagcagaagg tgctggagct gaccagtgac
      961 aatgaccgcc tgcgcaagcg ggtggaacag ctgagccgcg aactggacac gctgcggggc
     1021 atcttccgcc agctgccaga gagctccttg gtcaaggcca tgggcaactg cgcgtgaggc
     1081 gcgcggctgt gggaccgccc tgggccagcc tccggcgggg acccagggag tggtttgggg
     1141 tcgccggatc tcgaggcttg cccgagccgt gcgagccagg actaggagat tccggtgcct
     1201 cctgaaagcc tggcctgctc cgcgtgtccc ctcccttcct ctgcgccgga cttggtgcgt
     1261 ctaagatgag ggggccaggc ggtggcttct ccctgcgagg aggggagaat tcttggggct
     1321 gagctgggag cccggcaact ctagtattta ggataacctt gtgccttgga aatgcaaact
     1381 caccgctcca atgcctactg agtaggggga gcaaatcgtg ccttgtcatt ttatttggag
     1441 gtttcctgcc tccttcccga ggctacagca gacccccatg agagaaggag gggagcaggc
     1501 ccgtggcagg aggagggctc agggagctga gatcccgaca agcccgccag ccccagccgc
     1561 tcctccacgc ctgtccttag aaaggggtgg aaacataggg acttggggct tggaacctaa
     1621 ggttgttccc ctagttctac atgaaggtgg agggtctcta gttccacgcc tctcccacct
     1681 ccctccgcac acaccccacc ccagcctgct ataggctggg cttccccttg gggcggaact
     1741 cactgcgatg ggggtcacca ggtgaccagt gggagccccc accccgagtc acaccagaaa
     1801 gctaggtcgt gggtcagctc tgaggatgta tacccctggt gggagaggga gacctagaga
     1861 tctggctgtg gggcgggcat ggggggtgaa gggccactgg gaccctcagc cttgtttgta
     1921 ctgtatgcct tcagcattgc ctaggaacac gaagcacgat cagtccatcc cagagggacc
     1981 ggagttatga caagctttcc aaatattttg ctttatcagc cgatatcaac acttgtatct
     2041 ggcctctgtg ccccagcagt gccttgtgca atgtgaatgt gcgcgtctct gctaaaccac
     2101 cattttattt ggtttttgtt ttgttttggt tttgctcgga tacttgccaa aatgagactc
     2161 tccgtcggca gctgggggaa gggtctgaga ctccctttcc ttttggtttt gggattactt
     2221 ttgatcctgg gggaccaatg aggtgagggg ggttctcctt tgccctcagc tttccccagc
     2281 ccctccggcc tgggctgccc acaaggcttg tcccccagag gccctggctc ctggtcggga
     2341 agggaggtgg cctcccgcca acgcatcact ggggctggga gcagg
//

LOCUS       NM_004402               3034 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide
            (caspase-activated DNase) (DFFB), transcript variant 1, mRNA.
ACCESSION   NM_004402
VERSION     NM_004402.2  GI:51988888
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Bayascas,J.R., Yuste,V.J., Sole,C., Sanchez-Lopez,I., Segura,M.F.,
            Perera,R. and Comella,J.X.
  TITLE     Characterization of splice variants of human caspase-activated
            DNase with CIDE-N structure and function
  JOURNAL   FEBS Lett. 566 (1-3), 234-240 (2004)
   PUBMED   15147901
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Liu,Q.L., Kishi,H., Ohtsuka,K. and Muraguchi,A.
  TITLE     Heat shock protein 70 binds caspase-activated DNase and enhances
            its activity in TCR-stimulated T cells
  JOURNAL   Blood 102 (5), 1788-1796 (2003)
   PUBMED   12738667
  REMARK    GeneRIF: Hsp70 binds free CAD in TCR-stimulated T cells to
            stabilize and augment its activity.
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Widlak,P., Lanuszewska,J., Cary,R.B. and Garrard,W.T.
  TITLE     Subunit structures and stoichiometries of human DNA fragmentation
            factor proteins before and after induction of apoptosis
  JOURNAL   J. Biol. Chem. 278 (29), 26915-26922 (2003)
   PUBMED   12748178
  REMARK    GeneRIF: subunit structures and stoichiometries in human cells
            before and after induction of apoptosis
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Hsieh,S.Y., Liaw,S.F., Lee,S.N., Hsieh,P.S., Lin,K.H., Chu,C.M. and
            Liaw,Y.F.
  TITLE     Aberrant caspase-activated DNase (CAD) transcripts in human
            hepatoma cells
  JOURNAL   Br. J. Cancer 88 (2), 210-216 (2003)
   PUBMED   12610505
  REMARK    GeneRIF: Mutations and aberrantly spliced transcripts for the CAD
            gene are frequently associated with hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Judson,H., van Roy,N., Strain,L., Vandesompele,J., Van Gele,M.,
            Speleman,F. and Bonthron,D.T.
  TITLE     Structure and mutation analysis of the gene encoding DNA
            fragmentation factor 40 (caspase-activated nuclease), a candidate
            neuroblastoma tumour suppressor gene
  JOURNAL   Hum. Genet. 106 (4), 406-413 (2000)
   PUBMED   10830907
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   Mukae,N., Enari,M., Sakahira,H., Fukuda,Y., Inazawa,J., Toh,H. and
            Nagata,S.
  TITLE     Molecular cloning and characterization of human caspase-activated
            DNase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (16), 9123-9128 (1998)
   PUBMED   9689044
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Liu,X., Li,P., Widlak,P., Zou,H., Luo,X., Garrard,W.T. and Wang,X.
  TITLE     The 40-kDa subunit of DNA fragmentation factor induces DNA
            fragmentation and chromatin condensation during apoptosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (15), 8461-8466 (1998)
   PUBMED   9671700
REFERENCE   8  (bases 1 to 3034)
  AUTHORS   Halenbeck,R., MacDonald,H., Roulston,A., Chen,T.T., Conroy,L. and
            Williams,L.T.
  TITLE     CPAN, a human nuclease regulated by the caspase-sensitive inhibitor
            DFF45
  JOURNAL   Curr. Biol. 8 (9), 537-540 (1998)
   PUBMED   9560346
REFERENCE   9  (bases 1 to 3034)
  AUTHORS   Liu,X., Zou,H., Slaughter,C. and Wang,X.
  TITLE     DFF, a heterodimeric protein that functions downstream of caspase-3
            to trigger DNA fragmentation during apoptosis
  JOURNAL   Cell 89 (2), 175-184 (1997)
   PUBMED   9108473
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC032827.1, BC048797.1 and
            AF039210.1.
            On Sep 13, 2004 this sequence version replaced gi:4758149.
            
            Summary: Apoptosis is a cell death process that removes toxic
            and/or useless cells during mammalian development. The apoptotic
            process is accompanied by shrinkage and fragmentation of the cells
            and nuclei and degradation of the chromosomal DNA into nucleosomal
            units. DNA fragmentation factor (DFF) is a heterodimeric protein of
            40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for
            caspase-3 and triggers DNA fragmentation during apoptosis. DFF
            becomes activated when DFFA is cleaved by caspase-3. The cleaved
            fragments of DFFA dissociate from DFFB, the active component of
            DFF. DFFB has been found to trigger both DNA fragmentation and
            chromatin condensation during apoptosis. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            found for this gene, but the biological validity of some variants
            has not been determined.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.3"
     gene            1..3034
                     /gene="DFFB"
                     /note="synonyms: CAD, CPAN, DFF2, DFF40, DFF-40"
                     /db_xref="GeneID:1677"
                     /db_xref="MIM:601883"
     CDS             324..1340
                     /gene="DFFB"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     fragmentation factor, 40 kD, beta subunit;
                     caspase-activated DNase; DNA fragmentation factor, 40 kD,
                     beta polypeptide; caspase-activated nuclease;
                     caspase-activated deoxyribonuclease;
                     go_component: cytosol [goid 0005829] [evidence TAS] [pmid
                     9108473];
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     9108473];
                     go_component: intracellular [goid 0005622] [evidence IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: nuclease activity [goid 0004518] [evidence
                     IEA];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: caspase-activated deoxyribonuclease activity
                     [goid 0004537] [evidence TAS] [pmid 9671700];
                     go_process: apoptosis [goid 0006915] [evidence IEA];
                     go_process: intracellular signaling cascade [goid 0007242]
                     [evidence TAS] [pmid 9108473];
                     go_process: DNA fragmentation during apoptosis [goid
                     0006309] [evidence TAS] [pmid 9108473]"
                     /codon_start=1
                     /product="DNA fragmentation factor, 40 kD, beta
                     polypeptide isoform 1"
                     /protein_id="NP_004393.1"
                     /db_xref="GI:4758150"
                     /db_xref="GeneID:1677"
                     /db_xref="MIM:601883"
                     /translation="MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGS
                     RLCLYEDGTELTEDYFPSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQA
                     AQQLLCDEQAPQRQRLLADLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSC
                     ESRIRSYLREVSSYPSTVGAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLC
                     TPEGWFSCQGPFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAI
                     KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPV
                     RKRQ"
     polyA_signal    3006..3011
                     /gene="DFFB"
     polyA_site      3026
                     /gene="DFFB"
                     /evidence=experimental
     polyA_site      3028
                     /gene="DFFB"
ORIGIN      
        1 ccgctactct ggccctcagg gttgtgtagt ttccggggcc acggcacctg ggcacaccag
       61 gtggcgtcgc gcctttgctt tcctgagcct tctgagtaag gtaatgtggt gtccgtgggg
      121 cgacgcctgc gcacaagacc gcgtcgggcc tcacttttcc caggccttct gggtaatgta
      181 gtttccggga tcggcacccg gcctgtgcca gcttgcagag ctcaccaggt gcagacccct
      241 gcggccaggg cgaggacgga tctgagcagc tgggcagcag gtgccaccgc ctgtgggacc
      301 cagagggctt gaggacatct gcaatgctcc agaagcccaa gagcgtgaag ctgcgggccc
      361 tgcgcagccc gaggaagttc ggcgtggctg gccggagctg ccaggaggtg ctgcgcaagg
      421 gctgtctccg cttccagctc cctgagcgcg gttcccggct gtgcctgtac gaggatggca
      481 cggagctgac ggaagattac ttccccagtg ttcccgacaa cgccgagctg gtgctgctca
      541 ccttgggcca ggcctggcag ggctatgtga gcgacatcag gcgcttcctc agtgcatttc
      601 acgagccaca ggtggggctc atccaggccg cccagcagct gctgtgtgat gagcaggccc
      661 cacagaggca gaggctgctg gctgacctcc tgcacaacgt cagccagaac atcgcggccg
      721 agacccgggc tgaggacccg ccgtggtttg aaggcttgga gtcccgattt cagagcaagt
      781 ctggctatct gagatacagc tgtgagagcc ggatccggag ttacctgagg gaggtgagct
      841 cctacccctc cacggtgggt gcggaggctc aggaggaatt cctgcgggtc ctcggctcca
      901 tgtgccagag gctccggtcc atgcagtaca atggcagcta cttcgacaga ggagccaagg
      961 gcggcagccg cctctgcaca ccggaaggct ggttctcctg ccagggtccc tttgacatgg
     1021 acagctgctt atcaagacac tccatcaacc cctacagtaa cagggagagc aggatcctct
     1081 tcagcacctg gaacctggat cacataatag aaaagaaacg caccatcatt cctacactgg
     1141 tggaagcaat taaggaacaa gatggaagag aagtggactg ggagtatttt tatggcctgc
     1201 tttttacctc agagaaccta aaactagtgc acattgtctg ccataagaaa accacccaca
     1261 agctcaactg tgacccaagc agaatctaca aaccccagac aaggttgaag cggaagcagc
     1321 ctgtgcggaa acgccagtga cacgtacaca ccacgtcctg gtctttgttt gaggcctgac
     1381 gtgggcatca ttttaacagg tgcctttttt gtttttttgt ttttcgtttt tttggtcact
     1441 ccagtagctc ctggaaaaaa ccttaaaaaa tgtttcctcc aaatctgatt tcattacatt
     1501 tctgaattgt tggggttttt tttgttgttt tgttttgttt tgtagatgga gtttcacttt
     1561 tgttgcccag gctggagtgt agtggcgcga tctcggctca gcctcccgag tagctgggat
     1621 tacaggcatg tgccaccacg cccggctaat gtttgtattt ttagtagaga cggggtttca
     1681 ccatgttggt caggctggtc tcaaactcct gacctcaggt gatccgccca cctcagcctc
     1741 ccaaagtgct gggatgacag gtgtgagcca ctgcgcccag cctgaatcat ttcttatacc
     1801 ttctgacagc ccaacttcca gaggacagct ctggggtact cgttggatgt ctgtgagtac
     1861 ctggtcatac gggtcagtag ggataagaat tgtctctggg ctgaggaatt cttctgttct
     1921 ctggtttcac cagcgttggg tttgctcatg taatgtggtc accatactca aatggtgtca
     1981 tggctgaagt tggccacctt gcttgaggga caagttgttt atgtatcagc tctctgctgg
     2041 gtctcccttt ccatggcaaa tgggcagctc catcctcttg actcttctaa atgcccaaaa
     2101 gaggtgtcat gctttggggg tacgatgttt atactccgta aagaacatac aaggacattc
     2161 actgctgatt tttttttttg tttgtttgag acagggtctc actctgtcgc tcaggctgga
     2221 gtgcagtgat gcaatcttgg ctcactgcaa cctccgcctc tcaggttcaa gtggttctcc
     2281 tgcctcagcc tcccaagtag ctgggattac aggcacctac caccagggcc agctaatttt
     2341 tgtatgttta gtagaaacgg ggtttcacca tgttggccag gctgttctcg aactcctgac
     2401 ctcaggtgat ctgcccgcct cggtctccca aagtgctggg attacaggca tgagccactg
     2461 cacctgacct gctgaattgt ttataatggc aagaaatagg aaacccccca atgtctgttg
     2521 aacagctatc acgttgaacc acgtgaaact gctgttttct aggccaaaaa tggtgagcga
     2581 tcatttattt catgattcaa cctgatacat ttacatagtg caaaactgtg tcacagtttc
     2641 aggcttttat gaggaaagcg tttctgtgta gaaactggaa gctgttcagg gcatcggcag
     2701 ctgaaccctg ctccgttggt cagcgttact atcatctcgg atcatatgga gctcatgtca
     2761 gccgtgtggg tggcgggtgc acagagacgg tctggaagga aacacgcgga tctgaacagc
     2821 agtaatcctg ggggatacgg gggttgggct agattacaga gggctcattt tctacgtcat
     2881 gtattttatg atacttgaat tttttgaaat gggcatttat tttataacat gttaaaatgt
     2941 actttttaaa ttaagtcatt ttgtaatatt tgaattttta catttgttgt acaatcagga
     3001 aaagcaataa agatttttca aaaatagaaa aaaa
//

LOCUS       NM_004422               3046 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens dishevelled, dsh homolog 2 (Drosophila) (DVL2), mRNA.
ACCESSION   NM_004422
VERSION     NM_004422.2  GI:48762939
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3046)
  AUTHORS   Semenov,M.V. and Snyder,M.
  TITLE     Human dishevelled genes constitute a DHR-containing multigene
            family
  JOURNAL   Genomics 42 (2), 302-310 (1997)
   PUBMED   9192851
REFERENCE   2  (bases 1 to 3046)
  AUTHORS   Klingensmith,J., Yang,Y., Axelrod,J.D., Beier,D.R., Perrimon,N. and
            Sussman,D.J.
  TITLE     Conservation of dishevelled structure and function between flies
            and mice: isolation and characterization of Dvl2
  JOURNAL   Mech. Dev. 58 (1-2), 15-26 (1996)
   PUBMED   8887313
REFERENCE   3  (bases 1 to 3046)
  AUTHORS   Pizzuti,A., Amati,F., Calabrese,G., Mari,A., Colosimo,A.,
            Silani,V., Giardino,L., Ratti,A., Penso,D., Calza,L., Palka,G.,
            Scarlato,G., Novelli,G. and Dallapiccola,B.
  TITLE     cDNA characterization and chromosomal mapping of two human
            homologues of the Drosophila dishevelled polarity gene
  JOURNAL   Hum. Mol. Genet. 5 (7), 953-958 (1996)
   PUBMED   8817329
REFERENCE   4  (bases 1 to 3046)
  AUTHORS   Greco,T.L., Sussman,D.J. and Camper,S.A.
  TITLE     Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and
            vestigial tail (vt) on mouse chromosome 11
  JOURNAL   Mamm. Genome 7 (6), 475-476 (1996)
   PUBMED   8662242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG716400.1, CB994349.1,
            BC014844.1 and AK026019.1.
            On Jun 16, 2004 this sequence version replaced gi:4758215.
            
            Summary: This gene encodes a member of the dishevelled (dsh)
            protein family. The vertebrate dsh proteins have approximately 40%
            amino acid sequence similarity with Drosophila dsh. This gene
            encodes a 90-kD protein that undergoes posttranslational
            phosphorylation to form a 95-kD cytoplasmic protein, which may play
            a role in the signal transduction pathway mediated by multiple Wnt
            proteins. The mechanisms of dishevelled function in Wnt signaling
            are likely to be conserved among metazoans.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3046
                     /gene="DVL2"
                     /db_xref="GeneID:1856"
                     /db_xref="MIM:602151"
     CDS             283..2493
                     /gene="DVL2"
                     /note="DSH homolog 2; segment polarity protein dishevelled
                     homolog DVL-2; dishevelled 2 (homologous to Drosophila
                     dsh)"
                     /codon_start=1
                     /product="dishevelled 2"
                     /protein_id="NP_004413.1"
                     /db_xref="GI:4758216"
                     /db_xref="GeneID:1856"
                     /db_xref="MIM:602151"
                     /translation="MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFK
                     SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPP
                     VHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLR
                     RERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMS
                     RFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYN
                     FLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAV
                     RVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPA
                     YPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIP
                     NAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDL
                     SGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPP
                     PYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEP
                     SSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMV
                     VMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM"
     polyA_signal    2994..2999
                     /gene="DVL2"
     polyA_site      3013
                     /gene="DVL2"
                     /evidence=experimental
     polyA_site      3016
                     /gene="DVL2"
ORIGIN      
        1 agtcacgtga catgaggaga ggtgggcggg tacctggagg aagctcgcgg cgtcggtggc
       61 ggtggcgcgc ggcggccgct gagaccgggg ctttgagtcg caccccgcgg cccgcccccc
      121 gccgccaccc tcgcagatcc gtgctttttc ccctttgctt ctctcccgta ctgggtcagt
      181 cctgtccgcg ctcgcgcgtc ggtttgcggg tgtgcgcagg cgcggcaggg gccattagcc
      241 ctttgggtgg gcggtggagc ccgggagcgc gcgggcgaga ccatggcggg tagcagcact
      301 gggggcggtg gggttgggga gacgaaggtg atttaccacc tggatgagga agagactccc
      361 tacctggtga agatccctgt ccccgccgag cgcatcaccc tcggcgattt caagagcgtc
      421 ctgcagcggc ccgcgggcgc caagtacttt ttcaagtcta tggatcagga tttcggggtg
      481 gtgaaggaag aaatttcaga tgacaacgcc cgcctcccct gcttcaacgg aagggtggta
      541 tcctggctgg tgtcctcaga taatccccaa cccgagatgg cccctccagt ccatgagcct
      601 cgggcagaac tggcgcctcc agccccacct ttacctcctt tgccacccga gaggaccagc
      661 ggcattgggg actcaaggcc tccatccttc caccctaatg tgtccagcag ccatgagaat
      721 ctggagcctg agacagaaac cgagtcagta gtgtcactga ggcgggagcg gcctcgcagg
      781 agagacagca gtgagcatgg cgctgggggc cacaggactg gtggcccctc aaggctggag
      841 cgccacctgg ccggatacga gagctcctct accctcatga ccagcgagct ggagagtacc
      901 agcctggggg actcggacga ggaggacacc atgagcaggt tcagcagctc cacggagcag
      961 agcagtgcct cccgcctcct taagcgccac cggcggcgaa ggaagcagag gccaccccgc
     1021 ctggagagga cgtcatcctt cagcagcgtc acagattcca caatgtctct caatatcatc
     1081 acagtcacgc taaacatgga gaagtacaac ttcctgggta tctccattgt tggccagagc
     1141 aatgagcggg gagacggagg catctacatt ggctccatca tgaagggtgg ggctgtggcg
     1201 gccgacgggc gcattgagcc aggggacatg cttttgcagg tgaatgacat gaactttgag
     1261 aacatgagca acgatgacgc tgtgcgggtg ctgagggaca ttgtgcacaa gcctggcccc
     1321 attgtgctga ctgtggccaa gtgctgggat ccctctcctc aggcctattt cactctcccc
     1381 cgaaatgagc ccatccagcc aattgaccct gctgcctggg tgtcccattc cgcggctctg
     1441 actggcacct tcccagccta tccaggttcc tcctccatga gcaccattac atctggatcg
     1501 tctttgcctg atggctgtga aggccggggt ctctccgtcc atacggacat ggcatcggtg
     1561 accaaggcca tggcagctcc agagtctgga ctggaagtcc gggaccgcat gtggctcaag
     1621 atcaccatcc ctaatgcctt tctgggctcg gatgtggttg actggctcta ccatcacgtg
     1681 gagggctttc ctgagcggcg ggaggcccgc aagtatgcca gcgggctgct caaagcaggc
     1741 ctgatccgac acaccgtcaa caagatcacc ttctctgagc agtgctatta cgtcttcgga
     1801 gacctcagtg gtggctgtga gagctaccta gtcaacctgt ctctcaatga caacgatggc
     1861 tccagtgggg cttcagacca ggataccctg gctcctctgc ctggggccac cccctggccc
     1921 ctgctgccca ctttctccta ccaataccct gccccacacc cctacagccc gcagcctcca
     1981 ccctaccatg agctttcatc ttacacctat ggtgggggca gtgccagcag ccagcatagt
     2041 gagggcagcc ggagcagtgg gtcgacacgg agtgatgggg gggcagggcg cacggggagg
     2101 cccgaggagc gggcccccga gtccaagtcc ggcagtggca gtgagtctga gccctccagc
     2161 cgagggggca gccttcggcg gggtggggaa gcaagtggga ctagcgatgg gggccctcct
     2221 ccatccagag gctcaactgg gggtgcccct aatctccgag cccacccagg gctccatccc
     2281 tatggaccgc cccctggcat ggccctcccc tacaacccca tgatggtggt catgatgccc
     2341 ccacctccac ctccagtccc tccagcagtg cagcctccgg gggcccctcc agtcagagac
     2401 ctgggctctg tgcccccaga actgacagcc agccgccaaa gcttccacat ggccatgggc
     2461 aatcccagcg agttctttgt ggatgttatg tagcccactg tggggccagg ctgggccggg
     2521 cgctcctggt gtgtgactgg gtgtcctggc cgtcatgtgc ttgctcttac agtgcctggg
     2581 ctcagcctac cagctgctgc catacaggag attgtggcca ctgtgactct caccagcagt
     2641 gcctggttcc tcccccttcc ctcaggggta gacaagggac ctttgattat ttttagcttt
     2701 gtttttttat aagccttttt gggggttaaa atagagtttc ttacattttt gggacttttt
     2761 taataggcat ttcctctttt atatgaagaa ttcccatcca ttgggcccct tctaacccca
     2821 gaatgtgacc tcctcctcca gttacccaca gccctgccct ttgcagggtt gggggtggtc
     2881 agcggtaccc cggggttagg catcctagac agcagcctga ggaagctggg agatttgggc
     2941 catgtagctg cctttgttac tctatttatt ttagtcactt gtataaaaca ccaaataaag
     3001 caatagaggc aaactcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//

LOCUS       NM_004568               1665 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens serine (or cysteine) proteinase inhibitor, clade B
            (ovalbumin), member 6 (SERPINB6), mRNA.
ACCESSION   NM_004568
VERSION     NM_004568.4  GI:41152085
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Strik,M.C., Wolbink,A., Wouters,D., Bladergroen,B.A., Verlaan,A.R.,
            van Houdt,I.S., Hijlkema,S., Hack,C.E. and Kummer,J.A.
  TITLE     Intracellular serpin SERPINB6 (PI6) is abundantly expressed by
            human mast cells and forms complexes with beta-tryptase monomers
  JOURNAL   Blood 103 (7), 2710-2717 (2004)
   PUBMED   14670919
  REMARK    GeneRIF: In mast cells, SERPINB6 serves to regulate the activity of
            endogenous beta-tryptase in the cytoplasm.
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   (er) Mol. Vis. 8, 171-184 (2002)
  MEDLINE   22103463
   PUBMED   12107413
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Sun,J., Stephens,R., Mirza,G., Kanai,H., Ragoussis,J. and Bird,P.I.
  TITLE     A serpin gene cluster on human chromosome 6p25 contains PI6, PI9
            and ELANH2 which have a common structure almost identical to the
            18q21 ovalbumin serpin genes
  JOURNAL   Cytogenet. Cell Genet. 82 (3-4), 273-277 (1998)
  MEDLINE   99077772
   PUBMED   9858835
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Morgenstern,K.A., Sprecher,C., Holth,L., Foster,D., Grant,F.J.,
            Ching,A. and Kisiel,W.
  TITLE     Complementary DNA cloning and kinetic characterization of a novel
            intracellular serine proteinase inhibitor: mechanism of action with
            trypsin and factor Xa as model proteinases
  JOURNAL   Biochemistry 33 (11), 3432-3441 (1994)
  MEDLINE   94183847
   PUBMED   8136380
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Coughlin,P., Sun,J., Cerruti,L., Salem,H.H. and Bird,P.
  TITLE     Cloning and molecular characterization of a human intracellular
            serine proteinase inhibitor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (20), 9417-9421 (1993)
  MEDLINE   94022386
   PUBMED   8415716
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC001394.2, BI827451.1,
            CD674931.1, BM789272.1 and BI259189.1.
            On Jan 23, 2004 this sequence version replaced gi:28077084.
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25"
     gene            1..1665
                     /gene="SERPINB6"
                     /note="synonyms: CAP, PI6, PTI, MSTP057"
                     /db_xref="GeneID:5269"
                     /db_xref="MIM:173321"
     CDS             377..1507
                     /gene="SERPINB6"
                     /note="protease inhibitor 6 (placental thrombin
                     inhibitor);
                     go_component: cytosol [goid 0005829] [evidence TAS] [pmid
                     8415716];
                     go_function: protein binding [goid 0005515] [evidence TAS]
                     [pmid 8415716];
                     go_function: serine-type endopeptidase inhibitor activity
                     [goid 0004867] [evidence TAS] [pmid 8415716]"
                     /codon_start=1
                     /product="serine (or cysteine) proteinase inhibitor, clade
                     B (ovalbumin), member 6"
                     /protein_id="NP_004559.4"
                     /db_xref="GI:41152086"
                     /db_xref="GeneID:5269"
                     /db_xref="MIM:173321"
                     /translation="MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMG
                     AKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDF
                     LSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTR
                     LVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQI
                     LVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKL
                     EESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAAT
                     AAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP"
ORIGIN      
        1 gcactcccca gtggatggcc gtgtatcagg agccggccct tttctggaaa caggccagca
       61 ttcagtctcc acagaggcac cataaacacg ctggtggggc cctgtactgt ggtcaaagtc
      121 aaggcctccg ggcaggactc gcggcccctc cggctggcgg gtggggttga cccgcacgtc
      181 ccgccccgcc tctcccttcg cgctccggac gggcgacggt agctcgagac ccgggactcc
      241 gcccgcctcc ccgcgagtat ttgaggtccg gggcggctcc ggcgcctctg cccgccgttc
      301 tgctcgctcg ctccccgctc tggagtacgt gtctggcttg ggagccgctc ggacacgctg
      361 gcttgggtct gccatcatgg atgttctcgc agaagcaaat ggcacctttg ccttaaacct
      421 tttgaaaacg ctgggtaaag acaactcgaa gaatgtgttt ttctcaccca tgagcatgtc
      481 ctgtgccctg gccatggtct acatgggggc aaagggaaac accgctgcac agatggccca
      541 gatactttct ttcaataaaa gtggcggtgg tggagacatc caccagggct tccagtctct
      601 tctcaccgaa gtgaacaaga ctggcacgca gtacttgctt aggatggcca acaggctctt
      661 tggggaaaag tcttgtgatt tcctctcatc ttttagagat tcctgccaaa aattctacca
      721 agcagagatg gaggagcttg actttatcag cgccgtagag aagtccagaa aacacataaa
      781 cacctgggta gctgaaaaga cagaaggtaa aattgcggag ttgctctctc cgggctcagt
      841 ggatccattg acaaggctgg ttctggtgaa tgctgtctat ttcagaggaa actgggatga
      901 acagtttgac aaggagaaca ccgaggagag actgtttaaa gtcagcaaga atgaggagaa
      961 acctgtgcaa atgatgttta agcaatctac ttttaagaag acctatatag gagaaatatt
     1021 tacccaaatc ttggtgcttc catatgttgg caaggaactg aatatgatca tcatgcttcc
     1081 ggacgagacc actgacttga gaacggtgga gaaagaactc acttacgaga agttcgtaga
     1141 atggacgagg ctggacatga tggatgaaga ggaggtggaa gtgtccctcc cgcggtttaa
     1201 actagaggaa agctacgaca tggagagtgt cctgcgcaac ctgggcatga ctgatgcctt
     1261 cgagctgggc aaggcagact tctctggaat gtcccagaca gacctgtctc tgtccaaggt
     1321 cgtgcacaag tcttttgtgg aggtcaatga ggaaggcacg gaggctgcag ccgccacagc
     1381 tgccatcatg atgatgcggt gtgccagatt cgtcccccgc ttctgcgccg accacccctt
     1441 ccttttcttc atccagcaca gcaagaccaa cgggattctc ttctgcggcc gcttttcctc
     1501 tccgtgagga cagggcagtc ttggtgtgca gcccctctcc tctctgtccc ctgacactcc
     1561 acagtgtgcc tgcaacccaa gtggccttat ccgtgcagtg gtggcagttc agaaataaag
     1621 ggcccatttg tgggatgccg cattcaaaaa aaaaaaaaaa aaaaa
//

LOCUS       NM_004670               2415 bp    mRNA    linear   PRI 18-DEC-2004
DEFINITION  Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2
            (PAPSS2), mRNA.
ACCESSION   NM_004670
VERSION     NM_004670.2  GI:34447230
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Fuda,H., Shimizu,C., Lee,Y.C., Akita,H. and Strott,C.A.
  TITLE     Characterization and expression of human bifunctional
            3'-phosphoadenosine 5'-phosphosulphate synthase isoforms
  JOURNAL   Biochem. J. 365 (Pt 2), 497-504 (2002)
  MEDLINE   22090220
   PUBMED   11931637
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Shimizu,C., Fuda,H., Lee,Y.C. and Strott,C.A.
  TITLE     Transcriptional regulation of human 3'-phosphoadenosine
            5'-phosphosulphate synthase 2
  JOURNAL   Biochem. J. 363 (Pt 2), 263-271 (2002)
  MEDLINE   21929363
   PUBMED   11931653
  REMARK    GeneRIF: Transcriptional regulation of human 3'-phosphoadenosine
            5'-phosphosulphate synthase 2.
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Xu,Z.H., Otterness,D.M., Freimuth,R.R., Carlini,E.J., Wood,T.C.,
            Mitchell,S., Moon,E., Kim,U.J., Xu,J.P., Siciliano,M.J. and
            Weinshilboum,R.M.
  TITLE     Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1)
            and PAPSS2: gene cloning, characterization and chromosomal
            localization
  JOURNAL   Biochem. Biophys. Res. Commun. 268 (2), 437-444 (2000)
  MEDLINE   20145452
   PUBMED   10679223
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Kurima,K., Singh,B. and Schwartz,N.B.
  TITLE     Genomic organization of the mouse and human genes encoding the ATP
            sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2
  JOURNAL   J. Biol. Chem. 274 (47), 33306-33312 (1999)
  MEDLINE   20026854
   PUBMED   10559207
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   ul Haque,M.F., King,L.M., Krakow,D., Cantor,R.M., Rusiniak,M.E.,
            Swank,R.T., Superti-Furga,A., Haque,S., Abbas,H., Ahmad,W.,
            Ahmad,M. and Cohn,D.H.
  TITLE     Mutations in orthologous genes in human spondyloepimetaphyseal
            dysplasia and the brachymorphic mouse
  JOURNAL   Nat. Genet. 20 (2), 157-162 (1998)
  MEDLINE   98442651
   PUBMED   9771708
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Kurima,K., Warman,M.L., Krishnan,S., Domowicz,M., Krueger,R.C. Jr.,
            Deyrup,A. and Schwartz,N.B.
  TITLE     A member of a family of sulfate-activating enzymes causes murine
            brachymorphism
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (15), 8681-8685 (1998)
  MEDLINE   98337975
   PUBMED   9671738
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC009894.2 and
            AF160509.1.
            On Sep 4, 2003 this sequence version replaced gi:4758879.
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23-q24"
     gene            1..2415
                     /gene="PAPSS2"
                     /note="synonyms: SK2, ATPSK2"
                     /db_xref="GeneID:9060"
                     /db_xref="MIM:603005"
     CDS             112..1956
                     /gene="PAPSS2"
                     /EC_number="2.7.7.4"
                     /note="3-prime-phosphoadenosine 5-prime-phosphosulfate
                     synthase 2; bifunctional enzyme;
                     go_component: intracellular [goid 0005622] [evidence ISS];
                     go_function: ATP binding [goid 0005524] [evidence ISS];
                     go_function: nucleotidyltransferase activity [goid
                     0016779] [evidence ISS];
                     go_function: adenylyl-sulfate kinase activity [goid
                     0004020] [evidence IEA];
                     go_function: sulfate adenylyltransferase (ATP) activity
                     [goid 0004781] [evidence ISS];
                     go_process: skeletal development [goid 0001501] [evidence
                     ISS];
                     go_process: sulfate assimilation [goid 0000103] [evidence
                     IEA];
                     go_process: nucleobase, nucleoside, nucleotide and nucleic
                     acid metabolism [goid 0006139] [evidence NR]"
                     /codon_start=1
                     /product="3'-phosphoadenosine 5'-phosphosulfate synthase
                     2"
                     /protein_id="NP_004661.2"
                     /db_xref="GI:34447231"
                     /db_xref="GeneID:9060"
                     /db_xref="MIM:603005"
                     /translation="MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCT
                     VWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRR
                     IAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDV
                     KGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPY
                     TIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKE
                     YLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFY
                     EHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLE
                     LKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKD
                     DDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFY
                     IVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYD
                     PARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN"
ORIGIN      
        1 gtccggcagc cgctgctgct gctgctgctg ctgctgccgc cgccgccgcc gccgtccctg
       61 cgtccttcgg tctctgctcc cgggacccgg gctccgccgc agccagccag catgtcgggg
      121 atcaagaagc aaaagacgga gaaccagcag aaatccacca atgtagtcta tcaggcccac
      181 catgtgagca ggaataagag agggcaagtg gttggaacaa ggggtgggtt ccgaggatgt
      241 accgtgtggc taacaggtct ctctggtgct ggaaaaacaa cgataagttt tgccctggag
      301 gagtaccttg tctcccatgc catcccttgt tactccctgg atggggacaa tgtccgtcat
      361 ggccttaaca gaaatctcgg attctctcct ggggacagag aggaaaatat ccgccggatt
      421 gctgaggtgg ctaagctgtt tgctgatgct ggtctggtct gcattaccag ctttatttct
      481 ccattcgcaa aggatcgtga gaatgcccgc aaaatacatg aatcagcagg gctgccattc
      541 tttgaaatat ttgtagatgc acctctaaat atttgtgaaa gcagagacgt aaaaggcctc
      601 tataaaaggg ccagagctgg ggagattaaa ggatttacag gtattgattc tgattatgag
      661 aaacctgaaa ctcctgagcg tgtgcttaaa accaatttgt ccacagtgag tgactgtgtc
      721 caccaggtag tggaacttct gcaagagcag aacattgtac cctatactat aatcaaagat
      781 atccacgaac tctttgtgcc ggaaaacaaa cttgaccacg tccgagctga ggctgaaact
      841 ctcccttcat tatcaattac taagctggat ctccagtggg tccaggtttt gagcgaaggc
      901 tgggccactc ccctcaaagg tttcatgcgg gagaaggagt acttacaggt tatgcacttt
      961 gacaccctgc tagatgatgg cgtgatcaac atgagcatcc ccattgtact gcccgtctct
     1021 gcagaggata agacacggct ggaagggtgc agcaagtttg tcctggcaca tggtggacgg
     1081 agggtagcta tcttacgaga cgctgaattc tatgaacaca gaaaagagga acgctgttcc
     1141 cgtgtttggg ggacaacatg tacaaaacac ccccatatca aaatggtgat ggaaagtggg
     1201 gactggctgg ttggtggaga ccttcaggtg ctggagaaaa taagatggaa tgatgggctg
     1261 gaccaatacc gtctgacacc tctggagctc aaacagaaat gtaaagaaat gaatgctgat
     1321 gcggtgtttg cattccagtt gcgcaatcct gtccacaatg gccatgccct gttgatgcag
     1381 gacactcgcc gcaggctcct agagaggggc tacaagcacc cggtcctcct actacaccct
     1441 ctgggcggct ggaccaagga tgacgatgtg cctctagact ggcggatgaa gcagcacgcg
     1501 gctgtgctcg aggaaggggt cctggatccc aagtcaacca ttgttgccat ctttccgtct
     1561 cccatgttat atgctggccc cacagaggtc cagtggcact gcaggtcccg gatgattgcg
     1621 ggtgccaatt tctacattgt ggggagggac cctgcaggaa tgccccatcc tgaaaccaag
     1681 aaggatctgt atgaacccac tcatgggggc aaggtcttga gcatggcccc tggcctcacc
     1741 tctgtggaaa tcattccatt ccgagtggct gcctacaaca aagccaaaaa agccatggac
     1801 ttctatgatc cagcaaggca caatgagttt gacttcatct caggaactcg aatgaggaag
     1861 ctcgcccggg aaggagagaa tcccccagat ggcttcatgg cccccaaagc atggaaggtc
     1921 ctgacagatt attacaggtc cctggagaag aactaagcct ttggctccag agtttctttc
     1981 tgaagtgctc tttgattacc ttttctattt ttatgattag atgctttgta ttaaattgct
     2041 tctcaatgat gcattttaat cttttataat gaagtaaaag ttgtgtctat aattaaaaaa
     2101 aaatatatat atatacacac acacatatac atacaaagtc aaactgaaga ccaaatctta
     2161 gcaggtaaaa gcaatattct tatacatttc ataataaaat tagctctatg tattttctac
     2221 tgcacctgag caggcaggtc ccagatttct taaggctttg tttgaccatg tgtctagtta
     2281 cttgctgaaa agtgaatata ttttccagca tgtcttgaca acctgtactc ttccaatgtc
     2341 atttatcagt tgtaaaatat atcagattgt gtcctcttct gtacaattga caaaaaaaaa
     2401 aaaaaaaaaa aaaaa
//

LOCUS       NM_004685               4201 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens myotubularin related protein 6 (MTMR6), mRNA.
ACCESSION   NM_004685
VERSION     NM_004685.2  GI:37537693
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Nandurkar,H.H., Layton,M., Laporte,J., Selan,C., Corcoran,L.,
            Caldwell,K.K., Mochizuki,Y., Majerus,P.W. and Mitchell,C.A.
  TITLE     Identification of myotubularin as the lipid phosphatase catalytic
            subunit associated with the 3-phosphatase adapter protein, 3-PAP
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (15), 8660-8665 (2003)
   PUBMED   12847286
  REMARK    GeneRIF: Identification of myotubularin as the lipid phosphatase
            catalytic subunit associated with the 3-phosphatase adapter
            protein, 3-PAP.
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Schaletzky,J., Dove,S.K., Short,B., Lorenzo,O., Clague,M.J. and
            Barr,F.A.
  TITLE     Phosphatidylinositol-5-phosphate activation and conserved substrate
            specificity of the myotubularin phosphatidylinositol 3-phosphatases
  JOURNAL   Curr. Biol. 13 (6), 504-509 (2003)
   PUBMED   12646134
  REMARK    GeneRIF: investigation of MTM1 and MTMR6 and finding that they use
            PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro
REFERENCE   3  (bases 1 to 4201)
  AUTHORS   Laporte,J., Blondeau,F., Buj-Bello,A., Tentler,D., Kretz,C.,
            Dahl,N. and Mandel,J.L.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum. Mol. Genet. 7 (11), 1703-1712 (1998)
   PUBMED   9736772
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AK093237.1, BU177677.1,
            BC040012.1 and AK025507.1.
            On Oct 7, 2003 this sequence version replaced gi:22324935.
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12"
     gene            1..4201
                     /gene="MTMR6"
                     /db_xref="GeneID:9107"
                     /db_xref="MIM:603561"
     CDS             320..2185
                     /gene="MTMR6"
                     /note="go_component: cellular_component unknown [goid
                     0008372] [evidence ND] [pmid 9736772];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: protein tyrosine phosphatase activity [goid
                     0004725] [evidence NAS] [pmid 9736772];
                     go_function: protein serine/threonine phosphatase activity
                     [goid 0004722] [evidence NAS] [pmid 9736772];
                     go_process: protein amino acid dephosphorylation [goid
                     0006470] [evidence NAS] [pmid 9736772]"
                     /codon_start=1
                     /product="myotubularin related protein 6"
                     /protein_id="NP_004676.2"
                     /db_xref="GI:37537694"
                     /db_xref="GeneID:9107"
                     /db_xref="MIM:603561"
                     /translation="MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQK
                     ETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQA
                     KYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYP
                     RELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDE
                     HLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHV
                     MRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLAKAITVENASVLV
                     HCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKE
                     VSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKL
                     KEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHP
                     RQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKT
                     SLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC"
ORIGIN      
        1 cagtaccggc ctcctccagc agggggcgct gtgggatccg ccgctgtccg ggacgaacca
       61 gcaagccgct ctcggtccac acacgctctg tctgcctgcc ccgagtcccc cgggaggccg
      121 cggggtttgg ggaagtgttt ctaggagacg gcgctcaccg gctgcacctg cgccgttgac
      181 gccaccgggg ccggcagaca gacccgcggc gctggctggt ggagggagtt cccgcttgct
      241 ctctgtcgct gtcaccgccc tgtttctgta gccgtatggt acgcctgtga gaccggctgc
      301 cggctgacgt ctccttgcga tggagcatat ccggacgacc aaggtcgaac aagtaaaatt
      361 acttgaccga ttcagtacca gcaacaagtc attaacagga acactgtatc ttacggctac
      421 acatctatta tttatcgact ctcatcaaaa agaaacctgg atattacacc accatattgc
      481 ctcagtagag aaacttgctt tgactacttc tggatgcccc cttgtgatac agtgcaagaa
      541 cttcagaact gtgcatttca ttgttcccag agaaagagat tgccatgata tttacaactc
      601 tttgctacaa ctgtcaaaac aagcaaaata tgaagatctc tatgcatttt cttataatcc
      661 caaacaaaat gattcagaac gactacaagg ctggcagctc attgatctcg ctgaggaata
      721 taagaggatg ggagtgccaa actcacactg gcagttgtct gatgccaacc gggactacaa
      781 gatttgtgaa acttacccca gagaacttta tgttccccgg atagcaagca aaccaataat
      841 tgttggtagt tccaagttcc ggagcaaggg aagattccca gttctttcct actatcatca
      901 agataaggag gctgccattt gtcgatgtag tcagccactc tctggattca gtgccaggtg
      961 cctggaggat gaacatttgc ttcaagccat tagtaaagcc aatccagtca atcgctatat
     1021 gtacgtcatg gataccaggc caaaactgaa tgcaatggcc aacagagcag ctggaaaagg
     1081 ttatgaaaat gaagacaact attccaatat tagatttcag tttgttggaa ttgaaaatat
     1141 tcatgtcatg aggtccagcc ttcagaaatt attggaagtc aatggcacta aagggctttc
     1201 tgtcaatgat ttctactccg gtttggagag ctcgggatgg cttcgccata tcaaagctgt
     1261 tatggatgct gcagtcttct tggccaaagc aataacagtt gaaaatgcaa gtgtgttggt
     1321 gcattgttcc gatggttggg ataggacttc ccaggtttgt tccctgggtt ctcttttatt
     1381 ggattcctac tacaggacaa tcaaaggatt catggtttta atagaaaagg attggatctc
     1441 ttttggacat aaattttcag agaggtgtgg ccagttggat ggtgacccaa aggaagtctc
     1501 accagtgttt actcagttct tggaatgtgt gtggcatttg accgaacagt ttccacaagc
     1561 ctttgaattc agtgaagcat ttcttcttca gatccatgag catattcatt catgccagtt
     1621 tggaaacttc cttggaaatt gtcagaagga aagagaagag ctcaagttga aggagaagac
     1681 ttattccctg tggccatttc ttttggaaga ccaaaagaag tacttaaatc ctctctacag
     1741 ttccgaatct cacagattta cagttttgga gccaaataca gtatctttca attttaagtt
     1801 ttggaggaac atgtaccatc aatttgatcg aacactgcat cctaggcagt ctgtatttaa
     1861 tataattatg aatatgaatg agcaaaataa acaattagag aaagatatta aagacctaga
     1921 atctaaaatt aaacaacgca aaaataagca aacagatggc atcctcacca aggaattgtt
     1981 acattcagtt catcctgaat cacctaacct caaaacttcc ctgtgtttta aagagcagac
     2041 tctgctaccc gtaaatgatg ctcttcgaac tatagagggc agcagcccgg cagataatcg
     2101 ttatagtgaa tatgcagaag agttttctaa atcagaacct gctgtggtca gcttagagta
     2161 tggtgtggca agaatgactt gttagactca tagagttttt tctgcaatga ttgcagtaca
     2221 agaaaaggat tattgtgagg atggtctgta agcataacca aaaggaattt gtctaataac
     2281 aattttaggg tttaacagta ggctaatagt tgaaggaagg ataataacta cccttgtgag
     2341 agaaataagt cattttaatt gcatttccag caaggaatga cattcagttc tgtaagaaat
     2401 gagtggtatt tgatgtattt actcaaaaca caatttgcac tgtacactag tgaattgacg
     2461 tttatgattt atgttaattc agccaaacat aaataacctt ccttaagtac aatttaactt
     2521 caagaaaaca aaatttgaca acatagtttc ttaataaatg atatggcatg tactttcaat
     2581 tatgtagctt tgtaactatg aatatttaca tattttgcct tttagtgata tttaatgtta
     2641 aagtgccatg aaaaatattt ctaagaaagc cttaaattcc cagtggattc tttaccctta
     2701 agttttacag cctacaacaa gattttttgt tttgtttttc ttctggtcag ccttgttttg
     2761 tttgtaaaga attgtgctct cattactgct gggggtgcat gctacaatac ttctatataa
     2821 acacttgtag aagtacactg ttcacgttta gcctgcccca cttttgtatt caaaattaat
     2881 gaaactgaag gtttattctg atcataattt gtttagtgct acatttgata atttattatt
     2941 tacagcttag aatattgatt tcttgaatac gtataagcac atttgactgt cttttatata
     3001 tggattactg cattccattg attcttattt tgtggttggc tttatttctt tcacaactgt
     3061 gtaagtttaa agagctaaag ctctaaaact gttctgagaa acaatgaata gtacatgtat
     3121 atgtatattt ttaaactgcc ttattgctca atgagttgct gttcctggag tatctaactt
     3181 tcagtttact caaaaacttt tgggtaaata aaaaagggaa gtacagatag tttaggttgt
     3241 gcatggttgc atgaattttg aagtcatttc tatgtggagc attatttttc ttcttgttaa
     3301 atatagaaaa aaaaagagat tctagtacaa agttactgtt taacaaaagc aacataaact
     3361 ctgggaaaga tttcattttg ccatgttata tttactgttt attctgtgta ctagtacata
     3421 tctttaaatt accaaaaaac aagaaacaaa acataaaaac cccaaaacta tcacttggaa
     3481 ttagcaatat cacccaactg gctttaaaat tgaaaattta aataacatgg tggcatgaag
     3541 tacaattcga gtattaggca atttgcatag tgttcctcat gctactttct gttacacctc
     3601 tattatatta gttttgaata taaacatctt tttcagacca aaaaaaactt tattgtatga
     3661 gagcttatct tatcctgttt atttttccaa tgcttttctg taatacatta tgtaatttaa
     3721 aaaatattcc tttttaaaca gcaacagaaa tgcactataa aatatagtat gtgattaacc
     3781 aatcctgctt ccatatttaa gcactgggaa tggaaactta atctctgtga ctacaaaggg
     3841 aagtttttgt gccttggtgt tccagtcact gattgtggtt ttagaatctt ctgtggctga
     3901 cttcttgtat tcaactctgg tttattatct taatcttcaa cttcagacat atatttgtgt
     3961 gtttatatgc tcacaggtgg actgagaaat cagttacatc ttaagtgacc tacagggtat
     4021 atgttggcaa aagcagactg tgtatatgtc ttataaagtt gaatttatgt tcagtgtgtt
     4081 tggaagtgta tagcatgtaa attatttcat atatgattta aaggtaatta aatgttcaca
     4141 ttttactttg aatgtttttc ttctggataa aacaaatgga atcaaaaaaa aaaaaaaaaa
     4201 a
//

LOCUS       NM_004706               3236 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1
            (ARHGEF1), transcript variant 2, mRNA.
ACCESSION   NM_004706
VERSION     NM_004706.3  GI:39777602
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3236)
  AUTHORS   Wang,Q., Liu,M., Kozasa,T., Rothstein,J.D., Sternweis,P.C. and
            Neubig,R.R.
  TITLE     Thrombin and lysophosphatidic acid receptors utilize distinct
            rhoGEFs in prostate cancer cells
  JOURNAL   J. Biol. Chem. 279 (28), 28831-28834 (2004)
   PUBMED   15143072
  REMARK    GeneRIF: Data show that different rho guanine nucleotide exchange
            factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate
            downstream rho signaling by the thrombin and lysophosphatidic acid
            receptors.
REFERENCE   2  (bases 1 to 3236)
  AUTHORS   Bourguignon,L.Y., Singleton,P.A., Zhu,H. and Diedrich,F.
  TITLE     Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase
            promotes Grb2-associated binder-1 phosphorylation and
            phosphatidylinositol 3-kinase signaling leading to cytokine
            (macrophage-colony stimulating factor) production and breast tumor
            progression
  JOURNAL   J. Biol. Chem. 278 (32), 29420-29434 (2003)
   PUBMED   12748184
  REMARK    GeneRIF: CD44 interaction with p115RhoGEF and ROK plays a pivotal
            role in promoting Gab-1 phosphorylation leading to Gab-1.PI
            3-kinase membrane localization, AKT signaling, and cytokine (M-CSF)
            production during HA-mediated breast cancer progression
REFERENCE   3  (bases 1 to 3236)
  AUTHORS   Holinstat,M., Mehta,D., Kozasa,T., Minshall,R.D. and Malik,A.B.
  TITLE     Protein kinase Calpha-induced p115RhoGEF phosphorylation signals
            endothelial cytoskeletal rearrangement
  JOURNAL   J. Biol. Chem. 278 (31), 28793-28798 (2003)
   PUBMED   12754211
  REMARK    GeneRIF: data demonstrate a pathway of Rho activation involving
            protein kinase c alpha-dependent phosphorylation of p115Rho guanine
            exchange factor
REFERENCE   4  (bases 1 to 3236)
  AUTHORS   Chen,Z., Singer,W.D., Wells,C.D., Sprang,S.R. and Sternweis,P.C.
  TITLE     Mapping the Galpha13 binding interface of the rgRGS domain of
            p115RhoGEF
  JOURNAL   J. Biol. Chem. 278 (11), 9912-9919 (2003)
   PUBMED   12525488
  REMARK    GeneRIF: rgRGS domain may serve a structural or allosteric role in
            the regulation of the nucleotide exchange activity of p115RhoGEF on
            Rho by Galpha(13)
REFERENCE   5  (bases 1 to 3236)
  AUTHORS   Driessens,M.H., Olivo,C., Nagata,K., Inagaki,M. and Collard,J.G.
  TITLE     B plexins activate Rho through PDZ-RhoGEF
  JOURNAL   FEBS Lett. 529 (2-3), 168-172 (2002)
   PUBMED   12372594
  REMARK    GeneRIF: coexpression of a dominant negative PDZ-RhoGEF abrogated
            the ability of plexin-B1 to cause stress fiber formation
REFERENCE   6  (bases 1 to 3236)
  AUTHORS   Wells,C.D., Gutowski,S., Bollag,G. and Sternweis,P.C.
  TITLE     Identification of potential mechanisms for regulation of p115
            RhoGEF through analysis of endogenous and mutant forms of the
            exchange factor
  JOURNAL   J. Biol. Chem. 276 (31), 28897-28905 (2001)
   PUBMED   11384980
REFERENCE   7  (bases 1 to 3236)
  AUTHORS   Kozasa,T.
  TITLE     Regulation of G protein-mediated signal transduction by RGS
            proteins
  JOURNAL   Life Sci. 68 (19-20), 2309-2317 (2001)
   PUBMED   11358341
REFERENCE   8  (bases 1 to 3236)
  AUTHORS   Fukuhara,S., Chikumi,H. and Gutkind,J.S.
  TITLE     RGS-containing RhoGEFs: the missing link between transforming G
            proteins and Rho?
  JOURNAL   Oncogene 20 (13), 1661-1668 (2001)
   PUBMED   11313914
REFERENCE   9  (bases 1 to 3236)
  AUTHORS   Bhattacharyya,R. and Wedegaertner,P.B.
  TITLE     Galpha 13 requires palmitoylation for plasma membrane localization,
            Rho-dependent signaling, and promotion of p115-RhoGEF membrane
            binding
  JOURNAL   J. Biol. Chem. 275 (20), 14992-14999 (2000)
   PUBMED   10747909
REFERENCE   10 (bases 1 to 3236)
  AUTHORS   Aasheim,H.C., Pedeutour,F. and Smeland,E.B.
  TITLE     Characterization, expression and chromosomal localization of a
            human gene homologous to the mouse Lsc oncogene, with strongest
            expression in hematopoetic tissues
  JOURNAL   Oncogene 14 (14), 1747-1752 (1997)
   PUBMED   9135076
REFERENCE   11 (bases 1 to 3236)
  AUTHORS   Hart,M.J., Sharma,S., elMasry,N., Qiu,R.G., McCabe,P., Polakis,P.
            and Bollag,G.
  TITLE     Identification of a novel guanine nucleotide exchange factor for
            the Rho GTPase
  JOURNAL   J. Biol. Chem. 271 (41), 25452-25458 (1996)
   PUBMED   8810315
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM147791.1, BC011726.2 and
            BC005155.2.
            On Dec 12, 2003 this sequence version replaced gi:15011971.
            
            Summary: Rho GTPases play a fundamental role in numerous cellular
            processes that are initiated by extracellular stimuli that work
            through G protein coupled receptors. The encoded protein may form
            complex with G proteins and stimulate Rho-dependent signals.
            Multiple alternatively spliced transcript variants have been found
            for this gene, but the full-length nature of some variants has not
            been defined.
            
            Transcript Variant: This variant (2) has an alternate 5' exon and
            uses a downstream start codon, as compared to variant 1. The
            encoded isoform 2 thus has a shorter N-terminus, as compared to
            isoform 1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.13"
     gene            1..3236
                     /gene="ARHGEF1"
                     /note="synonyms: GEF1, LBCL2, SUB1.5, P115-RHOGEF"
                     /db_xref="GeneID:9138"
                     /db_xref="MIM:601855"
     CDS             110..2848
                     /gene="ARHGEF1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     115-kD protein; mouse Lsc homolog;
                     go_component: cytoplasm [goid 0005737] [evidence TAS]
                     [pmid 10747909];
                     go_component: plasma membrane [goid 0005886] [evidence
                     TAS] [pmid 10747909];
                     go_function: GTPase activator activity [goid 0005096]
                     [evidence IEA];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IEA];
                     go_function: Rho guanyl-nucleotide exchange factor
                     activity [goid 0005089] [evidence TAS] [pmid 8810315];
                     go_process: cell proliferation [goid 0008283] [evidence
                     TAS] [pmid 8810315];
                     go_process: regulation of cell cycle [goid 0000074]
                     [evidence TAS] [pmid 8810315];
                     go_process: Rho protein signal transduction [goid 0007266]
                     [evidence TAS] [pmid 10747909]"
                     /codon_start=1
                     /product="Rho guanine nucleotide exchange factor 1 isoform
                     2"
                     /protein_id="NP_004697.2"
                     /db_xref="GI:15011972"
                     /db_xref="GeneID:9138"
                     /db_xref="MIM:601855"
                     /translation="MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNS
                     QFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHS
                     FLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSK
                     RLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAV
                     VNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNR
                     GEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSP
                     DREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEP
                     EEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECL
                     FFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWF
                     QKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT
                     KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL
                     SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQD
                     ERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYEL
                     VAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETS
                     PADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGV
                     PGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT"
     polyA_site      3211
                     /gene="ARHGEF1"
                     /evidence=experimental
     polyA_site      3213
                     /gene="ARHGEF1"
ORIGIN      
        1 agagccagga agcgggagcc gggacccagg gcccgggatc gccgagcccg acctcgggcg
       61 ccccgccggt cacctccgcg cggacaccag ccctgcagag cccagggaga tggaagactt
      121 cgcccgaggg gcggcctccc caggcccctc ccggcctggc ctggttcccg tcagcatcat
      181 cggggctgag gatgaggatt ttgagaacga gctggagaca aactcagaag agcaaaacag
      241 ccagttccag agcctggagc aggtgaagcg gcgcccagcc cacctcatgg ccctcctgca
      301 gcacgtggcc ctgcagtttg agccaggacc cctgctttgc tgtctgcatg ccgacatgct
      361 gggctcactg ggccccaagg aggccaagaa ggccttcctg gacttctacc acagcttcct
      421 ggagaagaca gcggttctcc gggtgccggt ccctcccaac gtcgcctttg aacttgaccg
      481 cactagggct gacctcatct ccgaggatgt ccagcggcgg ttcgtgcagg aggtggtgca
      541 aagccagcag gtagccgtgg gccggcagct ggaggacttc cgttccaagc ggctcatggg
      601 catgacgccc tgggagcagg agctggccca gctggaggct tgggttgggc gggaccgagc
      661 cagctacgag gcccgggagc ggcacgtggc ggagcggctg ctcatgcacc tggaggagat
      721 gcaacatacc atctctaccg acgaagaaaa gagtgctgcc gtggtcaacg ccattggcct
      781 gtacatgcgc caccttgggg tgcggaccaa gagtggagac aagaagtcgg ggaggaactt
      841 cttccggaaa aaggtgatgg ggaaccggcg gtcggacgag cctgccaaga ccaagaaggg
      901 gctgagcagc atcctggatg ccgcccgctg gaaccgggga gagccccagg ttccagattt
      961 tcgacacctc aaagcagagg ttgatgccga gaagccaggt gctacagacc ggaagggagg
     1021 cgtggggatg ccctctcggg accggaatat cggggctcct gggcaggaca cccctggagt
     1081 ctctctgcac cctctgtccc tggacagccc agaccgggaa ccaggtgctg acgcccccct
     1141 ggagctgggg gactcatccc cgcagggccc aatgagcctg gagtccttgg cgcccccaga
     1201 gagtaccgac gagggggccg aaaccgagag ccccgagcct ggagatgagg gggagccggg
     1261 gcggtcggga ctggagcttg aaccagaaga gcctcccggc tggcgggaac tcgtcccccc
     1321 agacaccctg cacagcctgc ccaagagcca ggtgaagcgg caggaggtca tcagcgagct
     1381 gctggtgaca gaggcggccc acgtgcgcat gctgcgggtg ctgcacgacc tcttcttcca
     1441 gcccatggca gaatgcctgt tcttcccctt ggaggagctg cagaacatct tccccagcct
     1501 ggacgagctc atcgaggtgc attccctgtt cctcgatcgc ctgatgaagc ggaggcagga
     1561 gagtggctac ctcatcgagg agatcggaga cgtgctgctg gcccggtttg atggtgctga
     1621 gggctcctgg ttccagaaaa tctcctcccg cttctgcagc cgccagtcat ttgccttaga
     1681 gcagctcaaa gccaagcaac gcaaggaccc tcggttctgt gccttcgtgc aggaagctga
     1741 gagccgcccg cggtgccgcc gcctgcagct gaaggacatg atccccacgg agatgcagcg
     1801 gctgaccaag taccccctgc tcctgcagag catcgggcag aacacagaag agcccacaga
     1861 acgggagaaa gtggagctgg cagccgagtg ctgccgggaa attctacacc acgtcaacca
     1921 agccgtgcgt gacatggagg acctgctgag gctcaaggac tatcagcggc gcctggactt
     1981 gtcccacctt cggcagagca gcgaccctat gctgagcgag ttcaagaacc tggacatcac
     2041 caagaagaaa ttggtccacg agggcccact gacgtggcgg gtgactaagg acaaggcagt
     2101 ggaggtgcat gtgctgctgc tggacgacct gctgctgctg ctccagcgcc aggacgagcg
     2161 gctgctgctc aagtcccata gccggacact gacgcccacg cccgatggca agaccatgct
     2221 gcggcccgtg ctgcggctca cctccgccat gacccgcgag gtggccaccg atcacaaagc
     2281 cttctacgtc ctttttacct gggaccagga ggcccagata tacgagctgg tggcacagac
     2341 tgtgtcggag cggaaaaact ggtgtgctct catcactgag actgccggat ccctgaaagt
     2401 ccctgcccct gcctctcgcc ctaagccccg gcccagcccg agcagcaccc gagaacccct
     2461 cctcagcagc tctgagaacg gcaatggtgg ccgagagacg tctccagctg atgcccggac
     2521 cgagagaatc ctcagtgacc tcctgccctt ctgcagacca ggccccgagg gccagctcgc
     2581 tgccacggcc cttcggaaag tgctgtccct gaagcagctt ctgtttccgg cggaggaaga
     2641 caatggggcg gggcctcctc gagatgggga tggggtccca gggggcggcc ccctgagccc
     2701 agcacggacc caggaaatcc aggagaacct gctcagcttg gaggagacca tgaagcagct
     2761 ggaggagttg gaggaggaat tttgccgcct gagacccctc ctgtctcagc ttggggggaa
     2821 ctctgtcccc cagcctggct gcacttgagg ttcccgccca ggaaggcctt ttgcaagaag
     2881 gagaggaatg ggggagagga cgtgagggac cacccccacc cacacagctg ccgcagcatc
     2941 tcacaccccg agggcctgag gagagggagc tgtgggccac gcctgggagg ggcccagctg
     3001 gggttactgg ccccgcatga gcctcggcca tctctccctc ctgccctctg cttgggggac
     3061 tcagggctcc attctggagg gcaccacggt gacccgggcc atctcagtat tgcctgtggg
     3121 ggccacccct ccacccccac ccccaagtgc cttcgctctg tttttatacc ctgaattgga
     3181 ggtttatttt ttaatatata ttatctaaga agaaaaaaaa aaaaaaaaaa aaaaaa
//

LOCUS       NM_004710               1694 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens synaptogyrin 2 (SYNGR2), mRNA.
ACCESSION   NM_004710
VERSION     NM_004710.3  GI:52352813
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Kedra,D., Pan,H.Q., Seroussi,E., Fransson,I., Guilbaud,C.,
            Collins,J.E., Dunham,I., Blennow,E., Roe,B.A., Piehl,F. and
            Dumanski,J.P.
  TITLE     Characterization of the human synaptogyrin gene family
  JOURNAL   Hum. Genet. 103 (2), 131-141 (1998)
   PUBMED   9760194
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Janz,R. and Sudhof,T.C.
  TITLE     Cellugyrin, a novel ubiquitous form of synaptogyrin that is
            phosphorylated by pp60c-src
  JOURNAL   J. Biol. Chem. 273 (5), 2851-2857 (1998)
   PUBMED   9446595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ002308.1, BC000407.2,
            BC029755.1 and BF198109.1.
            On Sep 20, 2004 this sequence version replaced gi:22091455.
            
            Summary: This gene encodes an integral membrane protein containing
            four transmembrane regions and a C-terminal cytoplasmic tail that
            is tyrosine phosphorylated. The exact function of this protein is
            unclear, but studies of a similar rat protein suggest that it may
            play a role in regulating membrane traffic in non-neuronal cells.
            The gene belongs to the synaptogyrin gene family.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1694
                     /gene="SYNGR2"
                     /db_xref="GeneID:9144"
                     /db_xref="MIM:603926"
     CDS             28..702
                     /gene="SYNGR2"
                     /note="cellugyrin;
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 9760194]"
                     /codon_start=1
                     /product="synaptogyrin 2"
                     /protein_id="NP_004701.1"
                     /db_xref="GI:4759202"
                     /db_xref="GeneID:9144"
                     /db_xref="MIM:603926"
                     /translation="MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIY
                     GEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRK
                     YLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWG
                     VLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGY
                     QPPPVY"
     polyA_signal    1467..1472
                     /gene="SYNGR2"
     polyA_site      1488
                     /gene="SYNGR2"
                     /evidence=experimental
ORIGIN      
        1 ggcggcggca gcggcggcga cggcgacatg gagagcgggg cctacggcgc ggccaaggcg
       61 ggcggctcct tcgacctgcg gcgcttcctg acgcagccgc aggtggtggc gcgcgccgtg
      121 tgcttggtct tcgccttgat cgtgttctcc tgcatctatg gtgagggcta cagcaatgcc
      181 cacgagtcta agcagatgta ctgcgtgttc aaccgcaacg aggatgcctg ccgctatggc
      241 agtgccatcg gggtgctggc cttcctggcc tcggccttct tcttggtggt cgacgcgtat
      301 ttcccccaga tcagcaacgc cactgaccgc aagtacctgg tcattggtga cctgctcttc
      361 tcagctctct ggaccttcct gtggtttgtt ggtttctgct tcctcaccaa ccagtgggca
      421 gtcaccaacc cgaaggacgt gctggtgggg gccgactctg tgagggcagc catcaccttc
      481 agcttctttt ccatcttctc ctggggtgtg ctggcctccc tggcctacca gcgctacaag
      541 gctggcgtgg acgacttcat ccagaattac gttgacccca ctccggaccc caacactgcc
      601 tacgcctcct acccaggtgc atctgtggac aactaccaac agccaccctt cacccagaac
      661 gcggagacca ccgagggcta ccagccgccc cctgtgtact gagcggcggt tagcgtggga
      721 agggggacag agagggccct cccctctgcc ctggactttc ccatgagcct cctggaactg
      781 ccagcccctc tctttcacct gttccatcct gtgcagctga cacacagcta aggagcctca
      841 tagcctggcg ggggctggca gagccacacc ccaagtgcct gtgcccagag ggcttcagtc
      901 agccgctcac tcctccaggg cacttttagg aaagggtttt tagctagtgt ttttcctcgc
      961 ttttaatgac ctcagccccg cctgcagtgg ctagaagcca gcaggtgccc atgtgctact
     1021 gacaagtgcc tcagcttccc cccggcccgg gtcaggccgt gggagccgct attatctgcg
     1081 ttctctgcca aagactcgtg ggggccatca cacctgccct gtgcagcgga gccggaccag
     1141 gctcttgtgt cctcactcag gtttgcttcc cctgtgccca ctgctgtatg atctgggggc
     1201 caccaccctg tgccggtggc ctctgggctg cctcccgtgg tgtgagggcg gggctggtgc
     1261 tcatggcact tcctccttgc tcccacccct ggcagcaggg aagggctttg cctgacaaca
     1321 cccagcttta tgtaaatatt ctgcagttgt tacttaggaa gcctggggag ggcaggggtg
     1381 ccccatggct cccagactct gtctgtgccg agtgtattat aaaatcgtgg gggagatgcc
     1441 cggcctggga tgctgtttgg agacggaata aatgttttct cattcagtct ccagtcattg
     1501 gttgagccac agcctagggg ttggaggaag actccactct gggtacaccc ttaggggctg
     1561 gctttatgga acttgtagtt tgaacaaggc agtggcaatc cgccccctcc agcctgcctg
     1621 gctggccccc ttccctctgt ctggggtcgc attccgcaca agcctttcat caacatctta
     1681 aaatagtaac tgtg
//

LOCUS       NM_004781               2225 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens vesicle-associated membrane protein 3 (cellubrevin)
            (VAMP3), mRNA.
ACCESSION   NM_004781
VERSION     NM_004781.3  GI:42544205
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Polgar,J., Chung,S.H. and Reed,G.L.
  TITLE     Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are
            present in human platelets and are required for granule secretion
  JOURNAL   Blood 100 (3), 1081-1083 (2002)
   PUBMED   12130530
  REMARK    GeneRIF: VAMP-3 and VAMP-8 are present in human platelets and are
            required for granule secretion.
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Poschet,J.F., Skidmore,J., Boucher,J.C., Firoved,A.M., Van
            Dyke,R.W. and Deretic,V.
  TITLE     Hyperacidification of cellubrevin endocytic compartments and
            defective endosomal recycling in cystic fibrosis respiratory
            epithelial cells
  JOURNAL   J. Biol. Chem. 277 (16), 13959-13965 (2002)
   PUBMED   11809765
  REMARK    GeneRIF: Hyperacidification of cellubrevin endocytic compartments
            and defective endosomal recycling in cystic fibrosis respiratory
            epithelial cells
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Bernstein,A.M. and Whiteheart,S.W.
  TITLE     Identification of a cellubrevin/vesicle associated membrane protein
            3 homologue in human platelets
  JOURNAL   Blood 93 (2), 571-579 (1999)
   PUBMED   9885218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005941.1 and BC003570.1.
            On Feb 13, 2004 this sequence version replaced gi:9257252.
            
            Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD
            synaptosomal-associated protein are the main components of a
            protein complex involved in the docking and/or fusion of synaptic
            vesicles with the presynaptic membrane. This gene is a member of
            the vesicle-associated membrane protein (VAMP)/synaptobrevin
            family. Because of its high homology to other known VAMPs, its
            broad tissue distribution, and its subcellular localization, the
            protein encoded by this gene was shown to be the human equivalent
            of the rodent cellubrevin. In platelets the protein resides on a
            compartment that is not mobilized to the plasma membrane on calcium
            or thrombin stimulation.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..2225
                     /gene="VAMP3"
                     /note="synonym: CEB"
                     /db_xref="GeneID:9341"
                     /db_xref="MIM:603657"
     CDS             116..418
                     /gene="VAMP3"
                     /note="cellubrevin; synaptobrevin-3;
                     go_component: synapse [goid 0045202] [evidence IEA];
                     go_component: synaptosome [goid 0019717] [evidence IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence TAS] [pmid 9885218];
                     go_process: membrane fusion [goid 0006944] [evidence TAS]
                     [pmid 9885218];
                     go_process: protein complex assembly [goid 0006461]
                     [evidence TAS] [pmid 9885218];
                     go_process: vesicle docking during exocytosis [goid
                     0006904] [evidence TAS] [pmid 9885218]"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 3
                     (cellubrevin)"
                     /protein_id="NP_004772.1"
                     /db_xref="GI:4759300"
                     /db_xref="GeneID:9341"
                     /db_xref="MIM:603657"
                     /translation="MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLS
                     ELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS"
     polyA_signal    2184..2189
                     /gene="VAMP3"
     polyA_site      2202
                     /gene="VAMP3"
                     /evidence=experimental
     polyA_site      2205
                     /gene="VAMP3"
ORIGIN      
        1 agtgacgtct ttgccccgcg ccgcgccgtc ccacccatct ccctggcctc cggtcccaac
       61 ttcgcttctc tgctgaccct ctctcgtcgc cgctgccgcc gccgcagctg ccaaaatgtc
      121 tacaggtcca actgctgcca ctggcagtaa tcgaagactt cagcagacac aaaatcaagt
      181 agatgaggtg gtggacataa tgcgagttaa cgtggacaag gttctggaaa gagaccagaa
      241 gctctctgag ttagacgacc gtgcagacgc actgcaggca ggcgcttctc aatttgaaac
      301 gagcgcagcc aagttgaaga ggaaatattg gtggaagaat tgcaagatgt gggcaatcgg
      361 gattactgtt ctggttatct tcatcatcat catcatcgtg tgggttgtct cttcatgaag
      421 aaccagcgga actcaaaact gctgttcaag aaacctcttc aagacttttg acttagaacc
      481 tgctatatta tcaagcttac ctactgttat ctctaaaatt ttttttgtgt taatgtaaag
      541 ttgaatttct aggaaacgtg cctttgtttt ttaatatgca ctccaaatta gaaggccggc
      601 cccgtccaca ttttgcacag tgcctttaca gatttacgta tgggctgatg aagaggcctt
      661 cttaagttcc agagtgctat aatctagatg taatgttgtc actaattaat tgccattact
      721 cccagttagt tacccttgtc atttggcatt attttcagaa ccacatttta aacctttggg
      781 taatcagatt tccaacttat gccttccaga aaaaaacact actgcctaac acaaatctgt
      841 gataacaaca ggctgtgcct tattttgata attttctgat tccctagaag agaaccctct
      901 actttttgta agcactactg actctcgctg tatttaagat gctggtgaag agcttttgct
      961 cttgcattag atttgaagat gtttacattg ttgttattgt tatgtatcac ttgctaaaaa
     1021 tattgtttta atcagagata acctctttaa aaaaattttt aaagaactat ggctatgacc
     1081 aaagcttcta ttttgccaaa aagttaaata ccgataaaat ggccttaagt gtattcctga
     1141 cagttaaatt cagaaacgtg ccaaatggaa ctcaaggtgc cccttcagaa ttaaaatcat
     1201 taccttgtgt gtgaaccttc tacatcttca taggcctttc ttccttttga aaggctgtag
     1261 acagtgtggc tccccttctg attcagtatt ttgcatgggg gttagagaag gtttgaggta
     1321 gactctgacc gtctcataaa agagttctac ccagcagttg gcagattatc agctgtggac
     1381 tccagcatgt ttctgataat tatgcaagca acaattctgt agcctcaagt aagaccacct
     1441 gtgaacttga tcattatctg gcccaaatat gaagataaac tataactttg gagtttgttt
     1501 cctatttgta ttcacattct gcttcctaaa tcagttttct aaattatgcc tgcaattagg
     1561 cattggtcag gggtgaatgg ctcttttcac agagagtagc caaccagaga cctttgcttt
     1621 gatatcatca actgcagaga atgctgttga tgggaatgct ggaagcagaa actttgtcat
     1681 cggaaaaact tttcttgtat gcatgagact caacatcagg atccacagct taaagatggg
     1741 aattcaggta tgaaagaaaa caggcaagga ggcactgagg gagaaagaca cagactttat
     1801 cgctctgtgg ctcattgtta ctggaatatt ctaaaactct tgttcacatg ctattatgac
     1861 ttataaagca gcaacagctg aggcgcacca ggacacagct tccatttctt taacgtctgt
     1921 tcccttaaca tcgctgaaat gatttactgt tgaagagatg ccttgcggtg tggccagctg
     1981 tgaggagaaa gcagctggca gtgttaggac attagtccac cttcagcgca gggtctctgg
     2041 ccgggtctga ctcagaaacc ttggtactcg ccccttggcc acagtgccca gacccatgta
     2101 acccactggc tcctgcatta acccagaaat acctcgcttc tatctgtgca cttagctggg
     2161 aacttaccca ctgtaatcac ctaaataaag tgtttataaa catgaaaaaa aaaaaaaaaa
     2221 aaaaa
//

LOCUS       NM_004815               5585 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens PTPL1-associated RhoGAP 1 (PARG1), mRNA.
ACCESSION   NM_004815
VERSION     NM_004815.2  GI:38016931
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5585)
  AUTHORS   Saras,J., Franz, Aspenstr, Hellman,U., Gonez,L.J. and Heldin,C.H.
  TITLE     A novel GTPase-activating protein for Rho interacts with a PDZ
            domain of the protein-tyrosine phosphatase PTPL1
  JOURNAL   J. Biol. Chem. 272 (39), 24333-24338 (1997)
  MEDLINE   97450957
   PUBMED   9305890
REFERENCE   2  (bases 1 to 5585)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
  MEDLINE   96026280
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC022483.1, BI548487.1,
            BX508890.1, AA326126.1, U90920.1, AL833445.1, CB852768.1,
            CA454270.1, BU507990.1 and AW295796.1.
            On Oct 29, 2003 this sequence version replaced gi:4758881.
FEATURES             Location/Qualifiers
     source          1..5585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..5585
                     /gene="PARG1"
                     /db_xref="GeneID:9411"
     CDS             252..4037
                     /gene="PARG1"
                     /note="RP11-255E17.1; PTPL1-associated RhoGAP 1 (PARG1);
                     go_function: diacylglycerol binding [goid 0019992]
                     [evidence IEA];
                     go_function: Rho GTPase activator activity [goid 0005100]
                     [evidence TAS] [pmid 9305890];
                     go_process: intracellular signaling cascade [goid 0007242]
                     [evidence IEA];
                     go_process: Rho protein signal transduction [goid 0007266]
                     [evidence TAS] [pmid 9305890]"
                     /codon_start=1
                     /product="PTPL1-associated RhoGAP 1"
                     /protein_id="NP_004806.2"
                     /db_xref="GI:38016932"
                     /db_xref="GeneID:9411"
                     /translation="MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDY
                     IKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQ
                     NAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSL
                     LRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKY
                     TKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHL
                     LQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQ
                     RQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVC
                     VTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSL
                     CDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPD
                     SSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRK
                     LPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKC
                     RDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPD
                     GIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDIC
                     DVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINR
                     ILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPT
                     TAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSP
                     EERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQ
                     LLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASP
                     PNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQN
                     SLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASERRSSDS
                     YPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHGLVVK
                     SMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEDEIPQFV"
ORIGIN      
        1 gggcgggcgg tgcggccgtg gcggtagctg caggggcggt ggcggctgca gtggtggtgg
       61 tgcctgtggc tgtggctgcg gctgcggctg cggctgagat ttggccgggc gtccgcaggc
      121 cgtgggggat gggggcagcg agctccagcc ctcggcggtg gcggcggccg taggtgtggg
      181 gcgggcgtcc gcgtccggca cgcgagatgg agcgccgtgg atttcagttt ttctgactgt
      241 tacatgaaag gatgattgct cacaaacaga aaaagacaaa gaaaaaacgt gcttgggcat
      301 caggtcaact ctctactgat attacaactt ctgaaatggg gctcaagtcc ttaagttcca
      361 actctatttt tgatccggat tacatcaagg agttggtgaa tgatatcagg aagttctccc
      421 acatgttact atatttgaaa gaagccatat tttcagactg ttttaaagaa gttattcata
      481 tacgtctaga ggaactgctc cgtgttttaa agtctataat gaataaacat cagaacctca
      541 attctgttga tcttcaaaat gctgcagaaa tgctcactgc aaaagtgaaa gctgtgaact
      601 tcacagaagt taatgaagaa aacaaaaacg atctcttcca ggaagtgttt tcttctattg
      661 aaactttggc atttaccttt ggaaatatcc ttacaaactt ccttatggga gatgtaggca
      721 atgattcatt attgcgactg cctgtttctc gagaaactaa gtcgtttgaa aatgtttctg
      781 tggaatcagt ggactcatcc agtgaaaaag gaaatttttc ccctttagaa ctagacaacg
      841 tgctgttaaa gaacactgac tctatcgagc tggctttgtc atatgctaaa acttggtcaa
      901 aatatactaa gaacatagtt tcatgggttg aaaaaaagct taacttggaa ttggagtcca
      961 ctagaaatat ggtcaagttg gcagaggcaa ctagaactaa cattggaatt caggagttca
     1021 tgccactgca gtctctgttt actaatgctc ttcttaatga tatagaaagc agtcaccttt
     1081 tacaacaaac aattgcagct ctccaggcta acaaatttgt gcagcctcta cttggaagga
     1141 aaaatgaaat ggaaaaacaa aggaaagaaa taaaagagct ttggaaacag gagcaaaata
     1201 aaatgcttga agcagagaat gctctcaaaa aggcaaaatt attatgcatg caacgtcaag
     1261 atgaatatga gaaagcaaag tcttccatgt ttcgtgcaga agaggagcat ctgtcttcaa
     1321 gtggcggatt agcaaaaaat ctcaacaagc aactagaaaa aaagcgaagg ttggaagagg
     1381 aggctctcca aaaagtagaa gaagcaaatg aactttacaa agtttgtgtg acaaatgttg
     1441 aagaaagaag aaatgatcta gaaaatacca aaagagaaat tttagcacaa ctccggacac
     1501 ttgttttcca gtgtgatctt acccttaaag ctgtaacagt taacctcttc cacatgcagc
     1561 atctgcaggc tgcttccctt gcagacagtt tacagtctct ctgtgatagt gccaaactct
     1621 atgacccagg ccaagagtac agtgaatttg tcaaggccac aaattcaact gaagaagaaa
     1681 aagttgatgg aaatgtaaat aaacatttaa atagttccca accttcagga tttggacctg
     1741 ccaactcttt agaggatgtt gtacgccttc ctgacagttc taataaaatt gaagaggaca
     1801 gatgctctaa cagtgcagat ataacaggtc cttcctttat aagatcatgg acatttggga
     1861 tgtttagtga ttctgagagc actggaggga gcagcgaatc tagatctctg gattcagaat
     1921 ctataagtcc aggagacttt catcgaaaac ttccacgaac accatccagt ggaactatgt
     1981 cctctgcaga tgatctagat gaaagagagc caccttcccc ttcagaaact ggacccaatt
     2041 cccttggaac atttaagaaa acattgatgt caaaggcagc tctcacacac aagtttcgca
     2101 aattgagatc ccccacgaaa tgtagggatt gtgaaggcat tgtagtgttc caaggtgttg
     2161 aatgtgaaga gtgtctcctt gtttgtcatc gaaagtgttt ggaaaattta gtcattattt
     2221 gtggtcatca gaaacttcca ggaaaaatac acttatttgg agcagaattc acacaagttg
     2281 caaaaaagga accagatggt atccctttta tactcaaaat atgtgcctca gagattgaaa
     2341 atagagcttt gtgtctacag ggaatttatc gtgtgtgtgg aaacaaaata aaaactgaaa
     2401 aattgtgtca agctttggaa aatggaatgc acttggtaga tatttcagaa tttagttcac
     2461 atgatatctg tgacgtcttg aaattatacc ttcggcagct cccagaacca tttattttat
     2521 ttcgattgta caaggaattt atagaccttg caaaagagat ccaacatgta aatgaagaac
     2581 aagagacaaa aaagaatagt cttgaagaca aaaaatggcc aaatatgtgt atagaaataa
     2641 accgaattct tctaaaaagc aaagaccttc taagacaatt gccagcatca aattttaaca
     2701 gtcttcattt ccttatagta catctaaagc gggtagtaga tcatgcagaa gaaaacaaga
     2761 tgaactccaa aaacttgggg gtgatatttg gaccaagtct cattaggcca aggcccacaa
     2821 ctgctcctat caccatctcc tcccttgcag agtattcaaa tcaagcacgc ttggtagagt
     2881 ttctcattac ttactcacag aagatcttcg atgggtccct acaaccacaa gatgttatgt
     2941 gtagcatagg tgttgttgat caaggctgtt ttccaaagcc tctgttatca ccagaagaaa
     3001 gagacattga acgttccatg aagtcactat ttttttcttc aaaggaagat atccatactt
     3061 cagagagtga aagcaaaatt tttgaacgag ctacatcatt tgaggaatca gaacgcaagc
     3121 aaaatgcgtt aggaaaatgt gatgcatgtc tcagtgacaa agcacagttg cttctagacc
     3181 aagaggctga atcagcatcc caaaagatag aagatggtaa aacccctaag ccactttctc
     3241 tgaaatctga taggtcaaca aacaatgtgg agaggcatac tccaaggacc aagattagac
     3301 ctgtaagttt gcctgtagat agactacttc ttgcaagtcc tcctaatgag agaaatggca
     3361 gaaatatggg aaatgtaaat ttagacaagt tttgcaagaa tcctgccttt gaaggagtta
     3421 atagaaaaga cgctgctact actgtttgtt ccaaatttaa tggctttgac cagcaaactc
     3481 tacagaaaat tcaggacaaa cagtatgaac aaaacagcct aactgccaag actacaatga
     3541 tcatgcccag tgcactccag gaaaaaggag tgacaacaag cctccagatt agtggggacc
     3601 attctatcaa tgccactcaa cccagtaagc catatgcaga gccagtcagg tcagtgagag
     3661 aggcatctga gagacggtct tcagattcct accctctcgc tcctgtcaga gcacccagaa
     3721 cactgcagcc tcaacattgg acaacatttt ataaaccaca tgctcccatc atcagtatca
     3781 gggggaatga ggagaagcca gcttcaccct cagcagcagt gcctcctggc acagatcacg
     3841 atccccacgg tctcgtggtg aagtcaatgc cagacccaga caaagcatca gcttgtcctg
     3901 ggcaagcaac tggtcaacct aaagaagact ctgaggagct tggcttgcct gatgtgaatc
     3961 caatgtgtca gagaccaagg ctaaaacgaa tgcaacagtt tgaagacctc gaagatgaaa
     4021 ttccacaatt tgtgtaggga tgtcaaattt cagggttttt ttgttgttgt tgtgttattt
     4081 tgtggtattg tgcttgtttt gtgaaagaat gttttgacag ggcccctttt gtataggact
     4141 gccaaatcat gggttttgcc ttttgttgtt gtatttatcc tctgttggta atactgaatg
     4201 gtagaatgtt ttgatagggt cacatttgtg cctcactgga attatcttta aattctgtat
     4261 ttttaaagtt gtgaataaga taggtggatt cgtatttttt aaagttcagt tgactttccc
     4321 caccaaatgg tccatttgaa tgcatcccta atatatgata tagtctcaac taataggtgc
     4381 aatttgggaa aatcaggttt attttttgga gtggaactgt tataagtgct tatttataaa
     4441 aggaatgttt ctgaatgcaa gtgcctaaaa agatctttgt tggtatgcat atgttttgtc
     4501 acacaatttt atagtgcatc tttcaccatt tgtgcttttt taagatacgt atgtaagctc
     4561 ttatttttca attggcaatt cagttaattt ttaaatgttt acataatggc cagaaggctt
     4621 gcaaatctgt atttaattgc attttaatta attgccagtt tttacatgtg atagtcagtt
     4681 gtacaaagaa aatgcactta aacctgtttc taaattatat attcagttat attatatttg
     4741 gctttagatg gttttaatac atttgatagt ttttcacccc ttggctttat tttatataaa
     4801 cttttgtttt tcagcagttc tgaacttttt agtattttat aaatggtcca aaaaatgcct
     4861 gtttcagaag tttttgaatt cagtgcattt cctcttgatt tgtctgggtt aaaaccattc
     4921 cttttgtatg aaatgttttg acttaggaat cattttatgt acttgttcta cctggattgt
     4981 caacaactga aagtacatat ttcatccaaa tcaagctaaa atttatttaa gttgattctg
     5041 agagtacagg tcagtaagcc tcattatttg gaatttgaga gaaggtatag gtgatcggat
     5101 ctgtttcatt tataaaaggt ccagttttta ggactagtac attcctgtta ttttctgggt
     5161 tttatcattt tgcctaaaat aggatataaa agggacaaaa aataagtaga ctgtttttat
     5221 gtgtgaatta tatttctact aaatgttttt gtatgactgt gttatacttg ataatatata
     5281 tatatatata tatcaacttg ttaaattatt tcatgttccc gtggcttctt ttcagttgtt
     5341 gcctattaca gtatgagagt ttaaggttat taaccattgg cttagaagtc aacacctagg
     5401 atcatacatc cgttgactac aatgtggaat gaattttatg gaaacctgtt ttatagttct
     5461 atgtgatgta aaggtctagg gagcaataac cagccctttt ttttctgaag gcttgttttt
     5521 agtcctcatt gtacaaaata taaaataatc atattgctat gaatacctaa aaaaaaaaaa
     5581 aaaaa
//

LOCUS       NM_004817               4618 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens tight junction protein 2 (zona occludens 2) (TJP2),
            transcript variant 1, mRNA.
ACCESSION   NM_004817
VERSION     NM_004817.2  GI:42518069
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4618)
  AUTHORS   Andr, Pu,H., Deli,M.A., Nath,A., Hennig,B. and Toborek,M.
  TITLE     HIV-1 Tat protein alters tight junction protein expression and
            distribution in cultured brain endothelial cells
  JOURNAL   J. Neurosci. Res. 74 (2), 255-265 (2003)
  MEDLINE   22877269
   PUBMED   14515355
REFERENCE   2  (bases 1 to 4618)
  AUTHORS   Carlton,V.E., Harris,B.Z., Puffenberger,E.G., Batta,A.K.,
            Knisely,A.S., Robinson,D.L., Strauss,K.A., Shneider,B.L., Lim,W.A.,
            Salen,G., Morton,D.H. and Bull,L.N.
  TITLE     Complex inheritance of familial hypercholanemia with associated
            mutations in TJP2 and BAAT
  JOURNAL   Nat. Genet. 34 (1), 91-96 (2003)
  MEDLINE   22608349
   PUBMED   12704386
  REMARK    GeneRIF: Familial hypercholanemia in Amish individuals is
            associated with mutations in tight junction protein 2 (encoded by
            TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid
            N-acyltransferase (encoded by BAAT).
REFERENCE   3  (bases 1 to 4618)
  AUTHORS   Chlenski,A., Ketels,K.V., Korovaitseva,G.I., Talamonti,M.S.,
            Oyasu,R. and Scarpelli,D.G.
  TITLE     Organization and expression of the human zo-2 gene (tjp-2) in
            normal and neoplastic tissues
  JOURNAL   Biochim. Biophys. Acta 1493 (3), 319-324 (2000)
  MEDLINE   20472048
   PUBMED   11018256
REFERENCE   4  (bases 1 to 4618)
  AUTHORS   Beatch,M., Jesaitis,L.A., Gallin,W.J., Goodenough,D.A. and
            Stevenson,B.R.
  TITLE     The tight junction protein ZO-2 contains three PDZ
            (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced
            region
  JOURNAL   J. Biol. Chem. 271 (42), 25723-25726 (1996)
  MEDLINE   96421547
   PUBMED   8824195
REFERENCE   5  (bases 1 to 4618)
  AUTHORS   Duclos,F., Rodius,F., Wrogemann,K., Mandel,J.L. and Koenig,M.
  TITLE     The Friedreich ataxia region: characterization of two novel genes
            and reduction of the critical region to 300 kb
  JOURNAL   Hum. Mol. Genet. 3 (6), 909-914 (1994)
  MEDLINE   95038744
   PUBMED   7951235
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC027592.1, L27476.1 and
            BC028426.1.
            On Feb 11, 2004 this sequence version replaced gi:4759341.
            
            Summary: Tight junction proteins (TJPs) belong to a family of
            membrane-associated guanylate kinase (MAGUK) homologs that are
            involved in the organization of epithelial and endothelial
            intercellular junctions. TJPs bind to the cytoplasmic C termini of
            junctional transmembrane proteins and link them to the actin
            cytoskeleton.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..4618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q13-q21"
     gene            1..4618
                     /gene="TJP2"
                     /note="synonyms: ZO2, X104, ZO-2, MGC26306"
                     /db_xref="GeneID:9414"
                     /db_xref="MIM:607709"
     CDS             201..3773
                     /gene="TJP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Friedreich ataxia region gene X104 (tight junction protein
                     ZO-2);
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_component: tight junction [goid 0005923] [evidence NR];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence NR];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: guanylate kinase activity [goid 0004385]
                     [evidence TAS] [pmid 8824195]"
                     /codon_start=1
                     /product="tight junction protein 2 (zona occludens 2)
                     isoform 1"
                     /protein_id="NP_004808.2"
                     /db_xref="GI:42518070"
                     /db_xref="GeneID:9414"
                     /db_xref="MIM:607709"
                     /translation="MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGF
                     GIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAV
                     QQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSR
                     LNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRG
                     RSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHD
                     ARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTR
                     TGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINI
                     PSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLS
                     RMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGP
                     NTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGL
                     VREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLA
                     FTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDR
                     ADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIA
                     DIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAV
                     DLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA
                     TINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSC
                     DSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQ
                     MRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGA
                     STKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKM
                     DHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAP
                     SRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL"
     polyA_site      4601
                     /gene="TJP2"
ORIGIN      
        1 gccacgctcg ggtcgggggc gggctgacgc cgccgccgcc gcgggaggag ggacaaaggg
       61 gtgggtcccc gcgggtcggc accccggcgg ttgggctgcg ggtcagagca ctgtccggtg
      121 gtgcccagga ggagtaggag caggagcaga agcagaagcg gggtccggag ctgcgcgcct
      181 acgcgggacc tgtgtccgaa atgccggtgc gaggagaccg cgggtttcca ccccggcggg
      241 agctgtcagg ttggctccgc gccccaggca tggaagagct gatatgggaa cagtacactg
      301 tgaccctaca aaaggattcc aaaagaggat ttggaattgc agtgtccgga ggcagagaca
      361 acccccactt tgaaaatgga gaaacgtcaa ttgtcatttc tgatgtgctc ccgggtgggc
      421 ctgctgatgg gctgctccaa gaaaatgaca gagtggtcat ggtcaatggc acccccatgg
      481 aggatgtgct tcattcgttt gcagttcagc agctcagaaa aagtgggaag gtcgctgcta
      541 ttgtggtcaa gaggccccgg aaggtccagg tggccgcact tcaggccagc cctcccctgg
      601 atcaggatga ccgggctttt gaggtgatgg acgagtttga tggcagaagt ttccggagtg
      661 gctacagcga gaggagccgg ctgaacagcc atggggggcg cagccgcagc tgggaggaca
      721 gcccggaaag ggggcgtccc catgagcggg cccggagccg ggagcgggac ctcagccggg
      781 accggagccg tggccggagc ctggagcggg gcctggacca agaccatgcg cgcacccgag
      841 accgcagccg tggccggagc ctggagcggg gcctggacca cgactttggg ccatcccggg
      901 accgggaccg tgaccgcagc cgcggccgga gcattgacca ggactacgag cgagcctatc
      961 accgggccta cgacccagac tacgagcggg cctacagccc ggagtacagg cgcggggccc
     1021 gccacgatgc ccgctctcgg ggaccccgaa gccgcagccg cgagcacccg cactcacgga
     1081 gccccagccc cgagcctagg gggcggccgg ggcccatcgg ggtcctcctg atgaaaagca
     1141 gagcgaacga agagtatggt ctccggcttg ggagtcagat cttcgtaaag gaaatgaccc
     1201 gaacgggtct ggcaactaaa gatggcaacc ttcacgaagg agacataatt ctcaagatca
     1261 atgggactgt aactgagaac atgtctttaa cggatgctcg aaaattgata gaaaagtcaa
     1321 gaggaaaact acagctagtg gtgttgagag acagccagca gaccctcatc aacatcccgt
     1381 cattaaatga cagtgactca gaaatagaag atatttcaga aatagagtca aaccgatcat
     1441 tttctccaga ggagagacgt catcagtatt ctgattatga ttatcattcc tcaagtgaga
     1501 agctgaagga aaggccaagt tccagagagg acacgccgag cagattgtcc aggatgggtg
     1561 cgacacccac tccctttaag tccacagggg atattgcagg cacagttgtc ccagagacca
     1621 acaaggaacc cagataccaa gaggaccccc cagctcctca accaaaagca gccccgagaa
     1681 cttttcttcg tcctagtcct gaagatgaag caatatatgg ccctaatacc aaaatggtaa
     1741 ggttcaagaa gggagacagc gtgggcctcc ggttggctgg tggcaatgat gtcgggatat
     1801 ttgttgctgg cattcaagaa gggacctcgg cggagcagga gggccttcaa gaaggagacc
     1861 agattctgaa ggtgaacaca caggatttca gaggattagt gcgggaggat gccgttctct
     1921 acctgttaga aatccctaaa ggtgaaatgg tgaccatttt agctcagagc cgagccgatg
     1981 tgtatagaga catcctggct tgtggcagag gggattcgtt ttttataaga agccactttg
     2041 aatgtgagaa ggaaactcca cagagcctgg ccttcaccag aggggaggtc ttccgagtgg
     2101 tagacacact gtatgacggc aagctgggca actggctggc tgtgaggatt gggaacgagt
     2161 tggagaaagg cttaatcccc aacaagagca gagctgaaca aatggccagt gttcaaaatg
     2221 cccagagaga caacgctggg gaccgggcag atttctggag aatgcgtggc cagaggtctg
     2281 gggtgaagaa gaacctgagg aaaagtcggg aagacctcac agctgttgtg tctgtcagca
     2341 ccaagttccc agcttatgag agggttttgc tgcgagaagc tggtttcaag agacctgtgg
     2401 tcttattcgg ccccatagct gatatagcaa tggaaaaatt ggctaatgag ttacctgact
     2461 ggtttcaaac tgctaaaacg gaaccaaaag atgcaggatc tgagaaatcc actggagtgg
     2521 tccggttaaa taccgtgagg caaattattg aacaggataa gcatgcacta ctggatgtga
     2581 ctccgaaagc tgtggacctg ttgaattaca cccagtggtt cccaattgtg atttttttca
     2641 acccagactc cagacaaggt gtcaaaacca tgagacaaag gttaaatcca acgtccaaca
     2701 aaagttctcg aaagttattt gatcaagcca acaagcttaa aaaaacgtgt gcacaccttt
     2761 ttacagctac aatcaaccta aattcagcca atgatagctg gtttggcagc ttaaaggaca
     2821 ctattcagca tcagcaagga gaagcggttt gggtctctga aggaaagatg gaagggatgg
     2881 atgatgaccc cgaagaccgc atgtcctact taaccgccat gggcgcggac tatctgagtt
     2941 gcgacagccg cctcatcagt gactttgaag acacggacgg tgaaggaggc gcctacactg
     3001 acaatgagct ggatgagcca gccgaggagc cgctggtgtc gtccatcacc cgctcctcgg
     3061 agccggtgca gcacgaggag agcataagga aacccagccc agagccacga gctcagatga
     3121 ggagggctgc tagcagcgat caacttaggg acaatagccc gcccccagca ttcaagccag
     3181 agccgcccaa ggccaaaacc cagaacaaag aagaatccta tgacttctcc aaatcctatg
     3241 aatataagtc aaacccctct gccgttgctg gtaatgaaac tcctggggca tctaccaaag
     3301 gttatcctcc tcctgttgca gcaaaaccta cctttgggcg gtctatactg aagccctcca
     3361 ctcccatccc tcctcaagag ggtgaggagg tgggagagag cagtgaggag caagataatg
     3421 ctcccaaatc agtcctgggc aaagtcaaaa tatttgagaa gatggatcac aaggccaggt
     3481 tacagagaat gcaggagctc caggaagcac agaatgcaag gatcgaaatt gcccagaagc
     3541 atcctgatat ctatgcagtt ccaatcaaaa cgcacaagcc agaccctggc acgccccagc
     3601 acacgagttc cagaccccct gagccacaga aagctccttc cagaccttat caggatacca
     3661 gaggaagtta tggcagtgat gccgaggagg aggagtaccg ccagcagctg tcagaacact
     3721 ccaagcgcgg ttactatggc cagtctgccc gataccggga cacagaatta tagatgtctg
     3781 agcacggact ctcccaggcc tgcctgcatg gcatcagact agccactcct gccaggccgc
     3841 cgggatggtt cttctccagt tagaatgcac catggagacg tggtgggact ccagctcgtg
     3901 tgtcctcatg gagaacccag gggacagctg gtgcaaattc agaactgagg gctctgtttg
     3961 tgggactggg ttagaggagt ctgtggcttt ttgttcagaa ttaagcagaa cactgcagtc
     4021 agatcctgtt acttgcttca gtggaccgaa atctgtattc tgtttgcgta cttgtaatat
     4081 gtatattaag aagcaataac tatttttcct cattaatagc tgccttcaag gactgtttca
     4141 gtgtgagtca gaatgtgaaa aaggaataaa aaatactgtt gggctcaaac taaattcaaa
     4201 gaagtacttt attgcaactc ttttaagtgc cttggatgag aagtgtctta aattttcttc
     4261 ctttgaagct ttaggcagag ccataatgga ctaaaacatt ttgactaagt ttttatacca
     4321 gcttaatagc tgtagttttc cctgcactgt gtcatctttt caaggcattt gtctttgtaa
     4381 tattttccat aaatttggac tgtctatatc ataactatac ttgatagttt ggctataagt
     4441 gctcaatagc ttgaagccca agaagttggt atcgaaattt gttgtttgtt taaacccaag
     4501 tgctgcacaa aagcagatac ttgaggaaaa cactatttcc aaaagcacat gtattgacaa
     4561 cagttttata atttaataaa aaggaataca ttgcaatccg taaaaaaaaa aaaaaaaa
//

LOCUS       NM_004862               1773 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens lipopolysaccharide-induced TNF factor (LITAF), mRNA.
ACCESSION   NM_004862
VERSION     NM_004862.1  GI:4758913
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Bennett,C.L., Shirk,A.J., Huynh,H.M., Street,V.A., Nelis,E., Van
            Maldergem,L., De Jonghe,P., Jordanova,A., Guergueltcheva,V.,
            Tournev,I., Van Den Bergh,P., Seeman,P., Mazanec,R., Prochazka,T.,
            Kremensky,I., Haberlova,J., Weiss,M.D., Timmerman,V., Bird,T.D. and
            Chance,P.F.
  TITLE     SIMPLE mutation in demyelinating neuropathy and distribution in
            sciatic nerve
  JOURNAL   Ann. Neurol. 55 (5), 713-720 (2004)
   PUBMED   15122712
  REMARK    GeneRIF: The expression of SIMPLE is reported in various cell types
            of the sciatic nerve, including Schwann cells, the affected cell
            type in Charcot-Marie-Tooth neuropathy type 1C.
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Street,V.A., Bennett,C.L., Bird,T.D. and Chance,P.F.
  TITLE     New gene for CMT
  JOURNAL   J. Peripher. Nerv. Syst. 8 (4), 206 (2003)
   PUBMED   14641644
  REMARK    GeneRIF: New gene for CMT is located on chrosome 16.
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Moriwaki,Y., Begum,N.A., Kobayashi,M., Matsumoto,M., Toyoshima,K.
            and Seya,T.
  TITLE     Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall
            complex induce a novel lysosomal membrane protein, SIMPLE, that
            bridges the missing link between lipopolysaccharide and
            p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1
  JOURNAL   J. Biol. Chem. 276 (25), 23065-23076 (2001)
   PUBMED   11274176
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Myokai,F., Takashiba,S., Lebo,R. and Amar,S.
  TITLE     A novel lipopolysaccharide-induced transcription factor regulating
            tumor necrosis factor alpha gene expression: molecular cloning,
            sequencing, characterization, and chromosomal assignment
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (8), 4518-4523 (1999)
   PUBMED   10200294
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U77396.1.
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3-p12"
     gene            1..1773
                     /gene="LITAF"
                     /note="synonyms: PIG7, CMT1C, SIMPLE, TP53I7, FLJ38636"
                     /db_xref="GeneID:9516"
                     /db_xref="MIM:603795"
     CDS             234..920
                     /gene="LITAF"
                     /note="small integral membrane protein of lysosome/late
                     endosome; tumor protein p53 inducible protein 7;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IMP] [pmid 12761501];
                     go_function: RNA polymerase II transcription factor
                     activity [goid 0003702] [evidence TAS] [pmid 10200294];
                     go_process: regulation of transcription from Pol II
                     promoter [goid 0006357] [evidence TAS] [pmid 10200294];
                     go_process: positive regulation of I-kappaB
                     kinase/NF-kappaB cascade [goid 0043123] [evidence IMP]
                     [pmid 12761501]"
                     /codon_start=1
                     /product="LPS-induced TNF-alpha factor"
                     /protein_id="NP_004853.1"
                     /db_xref="GI:4758914"
                     /db_xref="GeneID:9516"
                     /db_xref="MIM:603795"
                     /translation="MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPT
                     TGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKM
                     IVSQLSYNAGALTWLSCGSLCLLGVHSGLLLHPLLRGCPAGRGPLLSQLQSSPGHLQA
                     FVGLSQTWREPGAAGSPFHLSSSFTPGGGSALVVSPLQGAHLHVFFWGEYVAKLTNLQ
                     TPEIAAWSRA"
ORIGIN      
        1 gtttctctcc ctgcccccgc gacttcgcgc aagatccggg aaggacaccc gaggcccctg
       61 ggagaccctg gggaggtgaa agtcagagag cgaagcgggc cgtggcccct aggcctgacc
      121 cctccccgcg gggtaaggcg ggcaccccgc gagcgcaggg gtcctcttac tgctgatggc
      181 acccagctct gggcccagac gccgctcacc gtccaccgcc ggtgctgggt aaaatgtcgg
      241 ttccaggacc ttaccaggcg gccactgggc cttcctcagc accatccgca cctccatcct
      301 atgaagagac agtggctgtt aacagttatt accccacacc tccagctccc atgcctgggc
      361 caactacggg gcttgtgacg gggcctgatg ggaagggcat gaatcctcct tcgtattata
      421 cccagccagc gcccatcccc aataacaatc caattaccgt gcagacggtc tacgtgcagc
      481 accccatcac ctttttggac cgccctatcc aaatgtgttg tccttcctgc aacaagatga
      541 tcgtgagtca gctgtcctat aacgccggtg ctctgacctg gctgtcctgc gggagcctgt
      601 gcctgctggg ggtgcatagc gggctgctgc ttcatcccct tctgcgtgga tgccctgcag
      661 gacgtggacc attactgtcc caactgcaga gctctcctgg gcacctacaa gcgtttgtag
      721 gactcagcca gacgtggagg gagccgggtg ccgcaggaag tcctttccac ctctcatcca
      781 gcttcacgcc tggtggaggt tctgccctgg tggtctcacc tctccagggg gcccaccttc
      841 atgtcttctt ttggggggaa tacgtcgcaa aactaacaaa tctccaaacc ccagaaattg
      901 ctgcttggag tcgtgcatag gacttgcaaa gacattcccc ttgagtgtca gttccacggt
      961 ttcctgcctc cctgagaccc tgagtcctgc catctaactg tgatcattgc cctatccgaa
     1021 tatcttcctg tgatctgcca tcagtggctc ttttttcctg cttccatggg cctttctggt
     1081 ggcagtctca aactgagaag ccacagttgc cttatttttg aggctgttct gcccagagct
     1141 cggctgaacc agcctttagt gcctaccatt atcttatccg tctcttcccg tccctgatga
     1201 caaagatctt gccttacaga ctttacaggc ttggctttga gattctgtaa ctgcagactt
     1261 cattagcaca cagattcact ttaatttctt aatttttttt ttaaatacaa ggagggggct
     1321 attaacaccc agtacagaca tatccacaag gtcgtaaatg catgctagaa aaatagggct
     1381 ggatcttatc actgccctgt ctccccttgt ttctctgtgc cagatcttca gtgccccttt
     1441 ccatacaggg atttttttct catagagtaa ttatatgaac agtttttatg acctcctttt
     1501 ggtctgaaat acttttgaac agaatttctt ttttttaaaa aaaaacagag atggggtctt
     1561 actatgttgc ccaggctggt gtcgaactcc tgggctcaag cgatccttct gccttggcct
     1621 cccgaagtgc tgggattgca ggcataagct accatgctgg gcctgaacat aatttcaaga
     1681 ggaggattta taaaaccatt ttctgtaatc aaatgattgg tgtcattttc ccatttgcca
     1741 atgtagtctc acttaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_004945               3621 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens dynamin 2 (DNM2), transcript variant 3, mRNA.
ACCESSION   NM_004945
VERSION     NM_004945.2  GI:56549118
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3621)
  AUTHORS   Lundmark,R. and Carlsson,S.R.
  TITLE     Regulated membrane recruitment of dynamin-2 mediated by sorting
            nexin 9
  JOURNAL   J. Biol. Chem. 279 (41), 42694-42702 (2004)
   PUBMED   15299020
  REMARK    GeneRIF: dynamin-2 membrane recruitment is mediated by sorting
            nexin 9
REFERENCE   2  (bases 1 to 3621)
  AUTHORS   Murph,M.M., Scaccia,L.A., Volpicelli,L.A. and Radhakrishna,H.
  TITLE     Agonist-induced endocytosis of lysophosphatidic acid-coupled
            LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway
  JOURNAL   J. Cell. Sci. 116 (Pt 10), 1969-1980 (2003)
  MEDLINE   22578411
   PUBMED   12668728
  REMARK    GeneRIF: dynamin2 and Rab5 have roles in endocytosis of
            lysophosphatidic acid-coupled LPA1/EDG-2 receptors
REFERENCE   3  (bases 1 to 3621)
  AUTHORS   Orth,J.D. and McNiven,M.A.
  TITLE     Dynamin at the actin-membrane interface
  JOURNAL   Curr. Opin. Cell Biol. 15 (1), 31-39 (2003)
  MEDLINE   22405488
   PUBMED   12517701
REFERENCE   4  (bases 1 to 3621)
  AUTHORS   Sever,S.
  TITLE     Dynamin and endocytosis
  JOURNAL   Curr. Opin. Cell Biol. 14 (4), 463-467 (2002)
  MEDLINE   22271382
   PUBMED   12383797
REFERENCE   5  (bases 1 to 3621)
  AUTHORS   Lee,E. and De Camilli,P.
  TITLE     Dynamin at actin tails
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (1), 161-166 (2002)
  MEDLINE   21642707
   PUBMED   11782545
  REMARK    GeneRIF: These findings suggest that dynamin is part of a protein
            network that controls nucleation of actin from membranes.
REFERENCE   6  (bases 1 to 3621)
  AUTHORS   Wiejak,J. and Wyroba,E.
  TITLE     Dynamin: characteristics, mechanism of action and function
  JOURNAL   Cell. Mol. Biol. Lett. 7 (4), 1073-1080 (2002)
  MEDLINE   22399570
   PUBMED   12511974
REFERENCE   7  (bases 1 to 3621)
  AUTHORS   Okamoto,P.M., Gamby,C., Wells,D., Fallon,J. and Vallee,R.B.
  TITLE     Dynamin isoform-specific interaction with the shank/ProSAP
            scaffolding proteins of the postsynaptic density and actin
            cytoskeleton
  JOURNAL   J. Biol. Chem. 276 (51), 48458-48465 (2001)
  MEDLINE   21611185
   PUBMED   11583995
REFERENCE   8  (bases 1 to 3621)
  AUTHORS   Fish,K.N., Schmid,S.L. and Damke,H.
  TITLE     Evidence that dynamin-2 functions as a signal-transducing GTPase
  JOURNAL   J. Cell Biol. 150 (1), 145-154 (2000)
  MEDLINE   20351424
   PUBMED   10893263
REFERENCE   9  (bases 1 to 3621)
  AUTHORS   Kasai,K., Shin,H.W., Shinotsuka,C., Murakami,K. and Nakayama,K.
  TITLE     Dynamin II is involved in endocytosis but not in the formation of
            transport vesicles from the trans-Golgi network
  JOURNAL   J. Biochem. 125 (4), 780-789 (1999)
  MEDLINE   99203583
   PUBMED   10101292
REFERENCE   10 (bases 1 to 3621)
  AUTHORS   Diatloff-Zito,C., Gordon,A.J., Duchaud,E. and Merlin,G.
  TITLE     Isolation of an ubiquitously expressed cDNA encoding human dynamin
            II, a member of the large GTP-binding protein family
  JOURNAL   Gene 163 (2), 301-306 (1995)
  MEDLINE   96011652
   PUBMED   7590285
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM148999.1, BC054501.1,
            BC039596.1, AK127033.1 and AK023207.1.
            On Dec 10, 2004 this sequence version replaced gi:4826699.
            
            Summary: Dynamins represent one of the subfamilies of GTP-binding
            proteins. These proteins share considerable sequence similarity
            over the N-terminal portion of the molecule, which contains the
            GTPase domain. Dynamins are associated with microtubules. They have
            been implicated in cell processes such as endocytosis and cell
            motility, and in alterations of the membrane that accompany certain
            activities such as bone resorption by osteoclasts. Dynamins bind
            many proteins that bind actin and other cytoskeletal proteins.
            Dynamins can also self-assemble, a process that stimulates GTPase
            activity. Four alternatively spliced transcripts encoding different
            proteins have been described. Additional alternatively spliced
            transcripts may exist, but their full-length nature has not been
            determined.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon, compared to variant 1. The resulting protein (isoform 3) is
            shorter, compared to isoform 1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3621
                     /gene="DNM2"
                     /note="synonyms: DYN2, DYNII"
                     /db_xref="GeneID:1785"
                     /db_xref="MIM:602378"
     CDS             165..2765
                     /gene="DNM2"
                     /EC_number="3.6.5.5"
                     /note="isoform 3 is encoded by transcript variant 3;
                     dynamin II; cytoskeletal protein; dynamin II {AA 474- 866]
                     [Homo sapiens]; DYN2_HUMAN [AA 474- 870];
                     go_component: cytoplasm [goid 0005737] [evidence NAS];
                     go_component: postsynaptic membrane [goid 0045211]
                     [evidence IDA] [pmid 11583995];
                     go_function: motor activity [goid 0003774] [evidence IEA];
                     go_function: GTP binding [goid 0005525] [evidence NAS]
                     [pmid 7590285];
                     go_function: enzyme binding [goid 0019899] [evidence NAS]
                     [pmid 11583995];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: GTPase activity [goid 0003924] [evidence NAS]
                     [pmid 11583995];
                     go_function: microtubule binding [goid 0008017] [evidence
                     NAS] [pmid 7590285];
                     go_function: transcriptional activator activity [goid
                     0016563] [evidence NAS] [pmid 10893263];
                     go_process: endocytosis [goid 0006897] [evidence NAS]
                     [pmid 10101292];
                     go_process: endocytosis [goid 0006897] [evidence NAS]
                     [pmid 11583995];
                     go_process: signal transduction [goid 0007165] [evidence
                     NAS] [pmid 10893263];
                     go_process: synaptic vesicle transport [goid 0048489]
                     [evidence NAS] [pmid 11583995];
                     go_process: regulation of transcription [goid 0045449]
                     [evidence NAS] [pmid 10893263];
                     go_process: positive regulation of apoptosis [goid
                     0043065] [evidence NAS] [pmid 10893263];
                     go_process: G2/M transition of mitotic cell cycle [goid
                     0000086] [evidence NAS] [pmid 7590285]"
                     /codon_start=1
                     /product="dynamin 2 isoform 3"
                     /protein_id="NP_004936.2"
                     /db_xref="GI:56549119"
                     /db_xref="GeneID:1785"
                     /db_xref="MIM:602378"
                     /translation="MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMI
                     LQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPH
                     LQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQ
                     QFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAI
                     KNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
                     RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNK
                     KRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNL
                     KIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPE
                     KDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINN
                     TKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTV
                     STPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAA
                     SFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTI
                     IRPAEPSLLD"
     polyA_signal    3588..3593
                     /gene="DNM2"
     polyA_signal    3598..3603
                     /gene="DNM2"
     polyA_site      3621
                     /gene="DNM2"
ORIGIN      
        1 gagaaccgga tgaggcggcg accgtgaggc cgagccggga gcgggcgtct tgccgaggcc
       61 cgggcgggcg gggagcaacg gctacagacg ccgcggggcc aggtcgttga gggtcggcgg
      121 cgggcgagga gcgcagggcg ctcgggccgg gggccgccgg cgccatgggc aaccgcggga
      181 tggaagagct gatcccgctg gtcaacaaac tgcaggacgc cttcagctcc atcggccaga
      241 gctgccacct ggacctgccg cagatcgctg tagtgggcgg ccagagcgcc ggcaagagct
      301 cggtgctgga gaacttcgtg ggccgggact tccttccccg cggttcagga atcgtcaccc
      361 ggcggcctct cattctgcag ctcatcttct caaaaacaga acatgccgag tttttgcact
      421 gcaagtccaa aaagtttaca gactttgatg aagtccggca ggagattgaa gcagagaccg
      481 acagggtcac ggggaccaac aaaggcatct ccccagtgcc catcaacctt cgagtctact
      541 cgccacacgt gttgaacttg accctcatcg acctcccggg tatcaccaag gtgcctgtgg
      601 gcgaccagcc tccagacatc gagtaccaga tcaaggacat gatcctgcag ttcatcagcc
      661 gggagagcag cctcattctg gctgtcacgc ccgccaacat ggacctggcc aactccgacg
      721 ccctcaagct ggccaaggaa gtcgatcccc aaggcctacg gaccatcggt gtcatcacca
      781 agcttgacct gatggacgag ggcaccgacg ccagggacgt cttggagaac aagttgctcc
      841 cgttgagaag aggctacatt ggcgtggtga accgcagcca gaaggatatt gagggcaaga
      901 aggacatccg tgcagcactg gcagctgaga ggaagttctt cctctcccac ccggcctacc
      961 ggcacatggc cgaccgcatg ggcacgccac atctgcagaa gacgctgaat cagcaactga
     1021 ccaaccacat ccgggagtcg ctgccggccc tacgtagcaa actacagagc cagctgctgt
     1081 ccctggagaa ggaggtggag gagtacaaga actttcggcc cgacgacccc acccgcaaaa
     1141 ccaaagccct gctgcagatg gtccagcagt ttggggtgga ttttgagaag aggatcgagg
     1201 gctcaggaga tcaggtggac actctggagc tctccggggg cgcccgaatc aatcgcatct
     1261 tccacgagcg gttcccattt gagctggtga agatggagtt tgacgagaag gacttacgac
     1321 gggagatcag ctatgccatt aagaacatcc atggagtcag gaccgggctt ttcaccccgg
     1381 acttggcatt cgaggccatt gtgaaaaagc aggtcgtcaa gctgaaagag ccctgtctga
     1441 aatgtgtcga cctggttatc caggagctaa tcaatacagt taggcagtgt accagtaagc
     1501 tcagttccta cccccggttg cgagaggaga cagagcgaat cgtcaccact tacatccggg
     1561 aacgggaggg gagaacgaag gaccagattc ttctgctgat cgacattgag cagtcctaca
     1621 tcaacacgaa ccatgaggac ttcatcgggt ttgccaatgc ccagcagagg agcacgcagc
     1681 tgaacaagaa gagagccatc cccaatcagg tgatccgcag gggctggctg accatcaaca
     1741 acatcagcct gatgaaaggc ggctccaagg agtactggtt tgtgctgact gccgagtcac
     1801 tgtcctggta caaggatgag gaggagaaag agaagaagta catgctgcct ctggacaacc
     1861 tcaagatccg tgatgtggag aagggcttca tgtccaacaa gcacgtcttc gccatcttca
     1921 acacggagca gagaaacgtc tacaaggacc tgcggcagat cgagctggcc tgtgactccc
     1981 aggaagacgt ggacagctgg aaggcctcgt tcctccgagc tggcgtctac cccgagaagg
     2041 accaggcaga aaacgaggat ggggcccagg agaacacctt ctccatggac ccccaactgg
     2101 agcggcaggt ggagaccatt cgcaacctgg tggactcata cgtggccatc atcaacaagt
     2161 ccatccgcga cctcatgcca aagaccatca tgcacctcat gatcaacaat acgaaggcct
     2221 tcatccacca cgagctgctg gcctacctat actcctcggc agaccagagc agcctcatgg
     2281 aggagtcggc tgaccaggca cagcggcggg acgacatgct gcgcatgtac catgccctca
     2341 aggaggcgct caacatcatc ggtgacatca gcaccagcac tgtgtccacg cctgtacccc
     2401 cgcctgtcga tgacacctgg ctccagagcg ccagcagcca cagccccact ccacagcgcc
     2461 gaccggtgtc cagcatacac ccccctggcc ggcccccagc agtgaggggc cccactccag
     2521 ggccccccct gattcctgtt cccgtggggg cagcagcctc cttctcggcg cccccaatcc
     2581 catcccggcc tggaccccag agcgtgtttg ccaacagtga cctcttccca gccccgcctc
     2641 agatcccatc tcggccagtt cggatccccc cagggattcc cccaggagtg cccagcagaa
     2701 gaccccctgc tgcgcccagc cggcccacca ttatccgccc agccgagcca tccctgctcg
     2761 actaggcctc gaggggggcg tgctctcggg ggggcctcac gcacccgcgg cgcaggagct
     2821 tcagtggtct ggggccctcc gccgccccta tgctgggacc aggctcccag tgggcagccc
     2881 tggcctcttc cttaacgctg gccccggtcc agggccggcc cctgtgcctg gctggacacc
     2941 gcactgcgca aaggggccct ggagctccag gcagggggcg ctggggtgtt gcactttggg
     3001 ggatggagtc tcagggtggc agagggggga ccagaaccct tgacaccatc ctgaatgagg
     3061 ggtccagcct gggggggact ctaccaaggt cttcttgggc tgggaaagcc catgtagggc
     3121 aggccttcta taagtgcggg caccaagggc gcctacatcc ccaggccttg ctggggtgca
     3181 ggggtatatc aacttcccat tagcaggagc tccccagcgg caagcctggc ccagtgggct
     3241 cggtagtgcc cagctggcag gcctgaggtg tacatagtcc ttcccggcca tattaaccac
     3301 acagcctgag cctggcccag cctcggctgc cagaggtgcc tttgctaggc ccggagccgt
     3361 tggcccgggc cggccttgcc ctattcctct cctcctcctc ctcctgggtc ccccagggtg
     3421 gctgggcttg ggctatgtgg gtggtggtgg cggggggtct tgggggcctc tcagctcccg
     3481 cccatgcctc cctgatgggt gggcccaggg cggcctctct ctgaggagac ctcacccact
     3541 cctcgctcag tttgaccact gtaagtgcct gcactctgta ttctattaat aaactaaaat
     3601 aaagggaaga cgctgctggt g
//

LOCUS       NM_005009               1059 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens non-metastatic cells 4, protein expressed in (NME4),
            mRNA.
ACCESSION   NM_005009
VERSION     NM_005009.2  GI:37675275
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1059)
  AUTHORS   Milon,L., Rousseau-Merck,M.F., Munier,A., Erent,M., Lascu,I.,
            Capeau,J. and Lacombe,M.L.
  TITLE     nm23-H4, a new member of the family of human nm23/nucleoside
            diphosphate kinase genes localised on chromosome 16p13
  JOURNAL   Hum. Genet. 99 (4), 550-557 (1997)
   PUBMED   9099850
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC017067.1 and BC004880.2.
            On Oct 15, 2003 this sequence version replaced gi:4826861.
            
            Summary: The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are
            ubiquitous enzymes that catalyze transfer of gamma-phosphates, via
            a phosphohistidine intermediate, between nucleoside and
            dioxynucleoside tri- and diphosphates. The enzymes are products of
            the nm23 gene family, which includes NME4. The first nm23 gene,
            nm23-H1 (NME1; MIM 156490), was isolated based on its reduced
            expression in a highly metastatic murine melanoma cell line and was
            proposed to be a metastasis suppressing gene. The human equivalent
            was obtained by cDNA library screening using the murine gene as a
            probe and found to be homologous to the Drosophila awd gene. A
            second human gene, nm23-H2 (NME2; MIM 156491), encoding a protein
            88% identical to nm23-H1, was subsequently isolated. Both genes
            were localized on 17q21.3 and their gene products were formerly
            identified as the A and B subunits of NDP kinases. Milon et al.
            (1997 [PubMed 9099850]) noted that in mammals, functional NDP
            kinases are heterohexamers of the A and B monomers, which can
            combine at variable ratios to form different types of hybrids.
            These enzymes are highly expressed in tumors as compared with
            normal tissues. In some cell lines and in certain solid tumors,
            decreased expression of NME1 is associated with increased
            metastatic potential; moreover, when transfected into very
            aggressive cell lines, such as human breast carcinoma, NME1
            decreased the metastatic potential. A third human gene, DR-nm23
            (NME3; MIM 601817), was identified and found to share high sequence
            similarity with the NME1 and NME2 genes. It is highly expressed in
            blast crisis transition of chronic myeloid leukemia. When
            overexpressed by transfection, NME3 suppressed granulocyte
            differentiation and induced apoptosis of myeloid precursor
            cells.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..1059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1059
                     /gene="NME4"
                     /note="synonyms: NM23H4, nm23-H4"
                     /db_xref="GeneID:4833"
                     /db_xref="MIM:601818"
     CDS             32..595
                     /gene="NME4"
                     /note="go_component: mitochondrion [goid 0005739]
                     [evidence TAS] [pmid 9099850];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: kinase activity [goid 0016301] [evidence
                     IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: nucleoside-diphosphate kinase activity [goid
                     0004550] [evidence TAS] [pmid 9099850];
                     go_process: CTP biosynthesis [goid 0006241] [evidence
                     IEA];
                     go_process: GTP biosynthesis [goid 0006183] [evidence
                     IEA];
                     go_process: UTP biosynthesis [goid 0006228] [evidence
                     IEA];
                     go_process: nucleoside metabolism [goid 0009116] [evidence
                     TAS] [pmid 9099850]"
                     /codon_start=1
                     /product="nucleoside-diphosphate kinase 4"
                     /protein_id="NP_005000.1"
                     /db_xref="GI:4826862"
                     /db_xref="GeneID:4833"
                     /db_xref="MIM:601818"
                     /translation="MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAV
                     KPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMS
                     SGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ
                     REIQLWFQSSELVSWADGGQHSSIHPA"
ORIGIN      
        1 cgcgctcaca gcggcccgcg ggccgggcgt catgggcggc ctcttctggc gctccgcgct
       61 gcgggggctg cgctgcggcc cgcgggcccc gggcccgagc ctgctagtgc gccacggctc
      121 gggagggccc tcctggaccc gggagcggac cctggtggcg gtgaagcccg atggcgtgca
      181 acggcggctc gttggggacg tgatccagcg ctttgagagg cggggcttca cgctggtggg
      241 gatgaagatg ctgcaggcac cagagagcgt ccttgccgag cactaccagg acctgcggag
      301 gaagcccttc taccctgccc tcatccgcta catgagctct gggcctgtgg tggccatggt
      361 ctgggaaggg tacaatgtcg tccgcgcctc gagggccatg attggacaca ccgactcggc
      421 tgaggctgcc ccaggaacca taaggggtga cttcagcgtc cacatcagca ggaatgtcat
      481 ccacgccagc gactccgtgg agggggccca gcgggagatc cagctgtggt tccagagcag
      541 tgagctggtg agctgggcag acgggggcca gcacagcagc atccacccag cctgaggctc
      601 aagctgccct taccacccca tcccccacgc aggaccaact acctccgtca gcaagaaccc
      661 aagcccacat ccaaacctgc ctgtcccaaa ccacttactt ccctgttcac ctctgcccca
      721 ccccagccca gaggagtttg agccaccaac ttcagtgcct ttctgtaccc caagccagca
      781 caagattgga ccaatccttt ttgcaccaaa gtgccggaca acctttgtgg tggggggggg
      841 tcttcacatt atcataacct ctcctctaaa ggggaggcat taaaattcac tgtgcccagc
      901 acatgggtgg tacactaatt atgacttccc ccagctctga ggtagaaatg acgcctttat
      961 gcaagttgta aggagttgaa cagtaaagag gaagttttgc acacccaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_005327               1877 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
            (HADHSC), mRNA.
ACCESSION   NM_005327
VERSION     NM_005327.1  GI:4885386
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Molven,A., Matre,G.E., Duran,M., Wanders,R.J., Rishaug,U.,
            Njolstad,P.R., Jellum,E. and Sovik,O.
  TITLE     Familial hyperinsulinemic hypoglycemia caused by a defect in the
            SCHAD enzyme of mitochondrial fatty acid oxidation
  JOURNAL   Diabetes 53 (1), 221-227 (2004)
   PUBMED   14693719
  REMARK    GeneRIF: SCHAD deficiency can result in persistent hyperinsulinemic
            hypoglycemia of infancy
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   He,X.Y., Merz,G., Yang,Y.Z., Mehta,P., Schulz,H. and Yang,S.Y.
  TITLE     Characterization and localization of human type10
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   Eur. J. Biochem. 268 (18), 4899-4907 (2001)
   PUBMED   11559359
  REMARK    GeneRIF: tissue distribution, subcellular localization, and
            metabolic functions
REFERENCE   3  (bases 1 to 1877)
  AUTHORS   Vredendaal,P.J., van den Berg,I.E., Malingre,H.E., Stroobants,A.K.,
            Olde Weghuis,D.E. and Berger,R.
  TITLE     Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and
            characterization of the coding sequence
  JOURNAL   Biochem. Biophys. Res. Commun. 223 (3), 718-723 (1996)
   PUBMED   8687463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X96752.1.
            
            Summary: Short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD; EC
            1.1.1.35) plays an essential role in the mitochondrial
            beta-oxidation of short chain fatty acids. It catalyzes the
            reversible dehydrogenation of 3-hydroxyacyl-CoAs to their
            corresponding 3-ketoacyl-CoAs with concomitant reduction of NAD to
            NADH and exerts it highest activity toward
            3-hydroxybutyryl-CoA.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22-q26"
     gene            1..1877
                     /gene="HADHSC"
                     /note="synonym: SCHAD"
                     /db_xref="GeneID:3033"
                     /db_xref="MIM:601609"
     CDS             88..1032
                     /gene="HADHSC"
                     /note="L-3-hydroxyacyl-CoA dehydrogenase, short chain;
                     go_component: mitochondrion [goid 0005739] [evidence TAS]
                     [pmid 8687463];
                     go_function: oxidoreductase activity [goid 0016491]
                     [evidence IEA];
                     go_function: 3-hydroxyacyl-CoA dehydrogenase activity
                     [goid 0003857] [evidence TAS] [pmid 8687463];
                     go_process: fatty acid metabolism [goid 0006631] [evidence
                     IEA]"
                     /codon_start=1
                     /product="L-3-hydroxyacyl-Coenzyme A dehydrogenase, short
                     chain"
                     /protein_id="NP_005318.1"
                     /db_xref="GI:4885387"
                     /db_xref="GeneID:3033"
                     /db_xref="MIM:601609"
                     /translation="MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQ
                     VAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIAT
                     STDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLHITSIANAT
                     TRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFI
                     VNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDG
                     WHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK"
     sig_peptide     88..126
                     /gene="HADHSC"
     mat_peptide     124..1029
                     /gene="HADHSC"
                     /product="L-3-hydroxyacyl-Coenzyme A dehydrogenase, short
                     chain"
ORIGIN      
        1 cgcccccaga gtctggcttt ccgcggctgc ccgcctcgcg cgtcttccct gcccgggtct
       61 cctcgctgtc gccgccgctg ccacaccatg gccttcgtca ccaggcagtt catgcgttcc
      121 gtgtcctcct cgtccaccgc ctcggcctcg gccaagaaga taatcgtcaa gcacgtgacg
      181 gtcatcggcg gcgggctgat gggcgccggc attgcccagg ttgctgcagc aactggtcac
      241 acagtagtgt tggtagacca gacagaggac atcctggcaa aatccaaaaa gggaattgag
      301 gaaagcctta ggaaagtggc aaagaagaag tttgcagaaa accctaaggc cggcgatgaa
      361 tttgtggaga agaccctgag caccatagcg accagcacgg atgcagcctc cgttgtccac
      421 agcacagact tggtggtgga agccatcgtg gagaatctga aggtgaaaaa cgagctcttc
      481 aaaaggctgg acaagtttgc tgctgaacat acaatctttg ccagcaacac ttcctccttg
      541 catattacaa gcatagctaa tgccaccacc agacaagacc gattcgctgg cctccatttc
      601 ttcaacccag tgcctgtcat gaaacttgtg gaggtcatta aaacaccaat gaccagccag
      661 aagacatttg aatctttggt agactttagc aaagccctag gaaagcatcc tgtttcttgc
      721 aaggacactc ctgggtttat tgtgaaccgc ctcctggttc catacctcat ggaagcaatc
      781 aggctgtatg aacgaggtga cgcatccaaa gaagacattg acactgctat gaaattagga
      841 gccggttacc ccatgggccc atttgagctt ctagattatg tcggactgga tactacgaag
      901 ttcatcgtgg atgggtggca tgaaatggat gcagagaacc cattacatca gcccagccca
      961 tccttaaata agctggtagc agagaacaag ttcggcaaga agactggaga aggattttac
     1021 aaatacaagt gatgtgcagc ttctccggct ctgagaagaa cacctgagag cgctttccag
     1081 ccagtgcccc gagtgcctgt gggaatgctc tttggtcaga cattccctca cacagtacag
     1141 tttaataaat gtgcattttg attgtaatct atcgaagtga ttattacacc agttacagca
     1201 gtaatagatt ctccattaag aaataattcc cttttttagt ctgttcattt ctgtgtattt
     1261 tctaaacagc tttacaccct tggtgccttg gagcaaacat gttttttgaa ccttgtcatt
     1321 tttgtgaaga attgcctaga ttccttctct catcaacggg aaagtacttc ctctgagagt
     1381 gcgagtgcac catgctcact gttgctgcgt gggagagtca caagccactg gcaagcaagt
     1441 ggtatagtct gtgaagcact gcagcgagca gcacctggat cttgccttta taagaacatt
     1501 ttactacctg cagctttgag tcttgcccta cattttgggc atgacataag atgtgtcttt
     1561 attcagctcg tcgtgaagat gctgctgctg aatgggtcag catatctctg tttgcatggt
     1621 ttgcaggagg tcggttttca tggtcattca gttccacaga tctgaatgat tactgtctgt
     1681 ctgtgtcttt tttccatgag aaatcactgt tgcaaattgc ctataaattg actctactaa
     1741 aataacaatg tttcagtctg aaaatttgaa ttgaaaaaaa tgtataatat aaaattgtaa
     1801 tacactcaaa tgattataaa agtaaaagtt ggtaatttag gcaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaa
//

LOCUS       NM_005397               5903 bp    mRNA    linear   PRI 15-OCT-2004
DEFINITION  Homo sapiens podocalyxin-like (PODXL), mRNA.
ACCESSION   NM_005397
VERSION     NM_005397.2  GI:33598949
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5903)
  AUTHORS   Somasiri,A., Nielsen,J.S., Makretsov,N., McCoy,M.L., Prentice,L.,
            Gilks,C.B., Chia,S.K., Gelmon,K.A., Kershaw,D.B., Huntsman,D.G.,
            McNagny,K.M. and Roskelley,C.D.
  TITLE     Overexpression of the anti-adhesin podocalyxin is an independent
            predictor of breast cancer progression
  JOURNAL   Cancer Res. 64 (15), 5068-5073 (2004)
   PUBMED   15289306
  REMARK    GeneRIF: Overexpression of the anti-adhesin podocalyxin is
            associated with breast cancer progression
REFERENCE   2  (bases 1 to 5903)
  AUTHORS   Koop,K., Eikmans,M., Baelde,H.J., Kawachi,H., De Heer,E., Paul,L.C.
            and Bruijn,J.A.
  TITLE     Expression of podocyte-associated molecules in acquired human
            kidney diseases
  JOURNAL   J. Am. Soc. Nephrol. 14 (8), 2063-2071 (2003)
   PUBMED   12874460
REFERENCE   3  (bases 1 to 5903)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   4  (bases 1 to 5903)
  AUTHORS   Schopperle,W.M., Kershaw,D.B. and DeWolf,W.C.
  TITLE     Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is
            podocalyxin
  JOURNAL   Biochem. Biophys. Res. Commun. 300 (2), 285-290 (2003)
   PUBMED   12504081
REFERENCE   5  (bases 1 to 5903)
  AUTHORS   Dias Neto,E., Correa,R.G., Verjovski-Almeida,S., Briones,M.R.,
            Nagai,M.A., da Silva,W. Jr., Zago,M.A., Bordin,S., Costa,F.F.,
            Goldman,G.H., Carvalho,A.F., Matsukuma,A., Baia,G.S., Simpson,D.H.,
            Brunstein,A., de Oliveira,P.S., Bucher,P., Jongeneel,C.V.,
            O'Hare,M.J., Soares,F., Brentani,R.R., Reis,L.F., de Souza,S.J. and
            Simpson,A.J.
  TITLE     Shotgun sequencing of the human transcriptome with ORF expressed
            sequence tags
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (7), 3491-3496 (2000)
   PUBMED   10737800
REFERENCE   6  (bases 1 to 5903)
  AUTHORS   Kershaw,D.B., Wiggins,J.E., Wharram,B.L. and Wiggins,R.C.
  TITLE     Assignment of the human podocalyxin-like protein (PODXL) gene to
            7q32-q33
  JOURNAL   Genomics 45 (1), 239-240 (1997)
   PUBMED   9339384
REFERENCE   7  (bases 1 to 5903)
  AUTHORS   Kershaw,D.B., Beck,S.G., Wharram,B.L., Wiggins,J.E., Goyal,M.,
            Thomas,P.E. and Wiggins,R.C.
  TITLE     Molecular cloning and characterization of human podocalyxin-like
            protein. Orthologous relationship to rabbit PCLP1 and rat
            podocalyxin
  JOURNAL   J. Biol. Chem. 272 (25), 15708-15714 (1997)
   PUBMED   9188463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U97519.1, BG006197.1 and
            BC042466.1.
            On Aug 12, 2003 this sequence version replaced gi:4885556.
            
            Summary: This gene encodes a member of the sialomucin protein
            family. The encoded protein was originally identified as an
            important component of glomerular podocytes. Podocytes are highly
            differentiated epithelial cells with interdigitating foot processes
            covering the outer aspect of the glomerular basement membrane.
            Other biological activities of the encoded protein include: binding
            in a membrane protein complex with Na+/H+ exchanger regulatory
            factor to intracellular cytoskeletal elements, playing a role in
            hematopoetic cell differentiation, and being expressed in vascular
            endothelium cells and binding to L-selectin.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32-q33"
     gene            1..5903
                     /gene="PODXL"
                     /note="synonyms: PCLP, Gp200"
                     /db_xref="GeneID:5420"
                     /db_xref="MIM:602632"
     CDS             251..1831
                     /gene="PODXL"
                     /note="go_component: integral to plasma membrane [goid
                     0005887] [evidence TAS] [pmid 9188463];
                     go_process: cell growth and/or maintenance [goid 0008151]
                     [evidence IEA]"
                     /codon_start=1
                     /product="podocalyxin-like precursor"
                     /protein_id="NP_005388.2"
                     /db_xref="GI:33598950"
                     /db_xref="GeneID:5420"
                     /db_xref="MIM:602632"
                     /translation="MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNK
                     TAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGP
                     VNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGG
                     KSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSST
                     VAIPGYTFTSPGMTTTLPSSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTP
                     TLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTL
                     CAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDV
                     YERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRFSMPLIITIVCMASFLLLVAALYGC
                     CHQRLSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVVSLNGELGDSWIV
                     PLDNLTKDDLDEEEDTHL"
     sig_peptide     251..316
                     /gene="PODXL"
     mat_peptide     317..1828
                     /gene="PODXL"
                     /product="podocalyxin-like"
     polyA_signal    5851..5856
                     /gene="PODXL"
     polyA_site      5871
                     /gene="PODXL"
                     /evidence=experimental
     polyA_site      5875
                     /gene="PODXL"
                     /evidence=experimental
     polyA_site      5880
                     /gene="PODXL"
                     /evidence=experimental
ORIGIN      
        1 agacgccgcc caggacgcag ccgccgccgc cgccgctcct ctgccactgg ctctgcgccc
       61 cagcccggct ctgctgcagc ggcagggagg aagagccgcc gcagcgcgac tcgggagccc
      121 cgggccacag cctggcctcc ggagccaccc acaggcctcc ccgggcggcg cccacgctcc
      181 taccgcccgg acgcgcggat cctccgccgg caccgcagcc acctgctccc ggcccagagg
      241 cgacgacacg atgcgctgcg cgctggcgct ctcggcgctg ctgctactgt tgtcaacgcc
      301 gccgctgctg ccgtcgtcgc cgtcgccgtc gccgtcgccc tcccagaatg caacccagac
      361 tactacggac tcatctaaca aaacagcacc gactccagca tccagtgtca ccatcatggc
      421 tacagataca gcccagcaga gcacagtccc cacttccaag gccaacgaaa tcttggcctc
      481 ggtcaaggcg accacccttg gtgtatccag tgactcaccg gggactacaa ccctggctca
      541 gcaagtctca ggcccagtca acactaccgt ggctagagga ggcggctcag gcaaccctac
      601 taccaccatc gagagcccca agagcacaaa aagtgcagac accactacag ttgcaacctc
      661 cacagccaca gctaaaccta acaccacaag cagccagaat ggagcagaag atacaacaaa
      721 ctctgggggg aaaagcagcc acagtgtgac cacagacctc acatccacta aggcagaaca
      781 tctgacgacc cctcacccta caagtccact tagcccccga caacccactt cgacgcatcc
      841 tgtggccacc ccaacaagct cgggacatga ccatcttatg aaaatttcaa gcagttcaag
      901 cactgtggct atccctggct acaccttcac aagcccgggg atgaccacca ccctaccgtc
      961 atcggttatc tcgcaaagaa ctcaacagac ctccagtcag atgccagcca gctctacggc
     1021 cccttcctcc caggagacag tgcagcccac gagcccggca acggcattga gaacacctac
     1081 cctgccagag accatgagct ccagccccac agcagcatca actacccacc gataccccaa
     1141 aacaccttct cccactgtgg ctcatgagag taactgggca aagtgtgagg atcttgagac
     1201 acagacacag agtgagaagc agctcgtcct gaacctcaca ggaaacaccc tctgtgcagg
     1261 gggcgcttcg gatgagaaat tgatctcact gatatgccga gcagtcaaag ccaccttcaa
     1321 cccggcccaa gataagtgcg gcatacggct ggcatctgtt ccaggaagtc agaccgtggt
     1381 cgtcaaagaa atcactattc acactaagct ccctgccaag gatgtgtacg agcggctgaa
     1441 ggacaaatgg gatgaactaa aggaggcagg ggtcagtgac atgaagctag gggaccaggg
     1501 gccaccggag gaggccgagg accgcttcag catgcccctc atcatcacca tcgtctgcat
     1561 ggcatcattc ctgctcctcg tggcggccct ctatggctgc tgccaccagc gcctctccca
     1621 gaggaaggac cagcagcggc taacagagga gctgcagaca gtggagaatg gttaccatga
     1681 caacccaaca ctggaagtga tggagacctc ttctgagatg caggagaaga aggtggtcag
     1741 cctcaacggg gagctggggg acagctggat cgtccctctg gacaacctga ccaaggacga
     1801 cctggatgag gaggaagaca cacacctcta gtccggtctg ccggtggcct ccagcagcac
     1861 cacagagctc cagaccaacc accccaagtg ccgtttggat ggggaaggga aagactgggg
     1921 agggagagtg aactccgagg ggtgtcccct cccaatcccc ccagggcctt aatttttccc
     1981 ttttcaacct gaacaaatca cattctgtcc agattcctct tgtaaaataa cccactagtg
     2041 cctgagctca gtgctgctgg atgatgaggg agatcaagaa aaagccacgt aagggacttt
     2101 atagatgaac tagtggaatc ccttcattct gcagtgagat tgccgagacc tgaagagggt
     2161 aagtgacttg cccaaggtca gagccacttg gtgacagagc caggatgaga acaaagattc
     2221 catttgcacc atgccacact gctgtgttca catgtgcctt ccgtccagag cagtcccggg
     2281 caggggtgaa actccagcag gtggctgggc tggaaaggag ggcagggcta catcctggct
     2341 cggtgggatc tgacgacctg aaagtccagc tcccaagttt tccttctcct accccagcct
     2401 cgtgtaccca tcttcccacc ctctatgttc ttacccctcc ctacactcag tgtttgttcc
     2461 cacttactct gtcctggggc ctctgggatt agcacaggtt attcataacc ttgaacccct
     2521 tgttctggat tcggattttc tcacatttgc ttcgtgagat gggggcttaa cccacacagg
     2581 tctccgtgcg tgaaccaggt ctgcttaggg gacctgcgtg caggtgagga gagaagggga
     2641 cactcgagtc caggctggta tctcagggca gctgatgagg ggtcagcagg aacactggcc
     2701 cattgcccct ggcactcctt gcagaggcca cccacgatct tctttgggct tccatttcca
     2761 ccagggacta aaatctgctg tagctagtga gagcagcgtg ttccttttgt tgttcactgc
     2821 tcagctgatg ggagtgattc cctgagaccc agtatgaaag agcagtggct gcaggagagg
     2881 ccttcccggg gccccccatc agcgatgtgt cttcagagac aatccattaa agcagccagg
     2941 aaggacaggc tttcccctgt atatcatagg aaactcaggg acatttcaag ttgctgagag
     3001 ttttgttata gttgttttct aacccagccc tccactgcca aaggccaaaa gctcagacag
     3061 ttggcagacg tccagttagc tcatctcact cactctgatt ctcctgtgcc acaggaaaag
     3121 agggcctgga aagcgcagtg catgctgggt gcatgaaggg cagcctgggg gacagactgt
     3181 tgtgggaacg tcccactgtc ctggcctgga gctaggcctt gctgttcctc ttctctgtga
     3241 gcctagtggg gctgctgcgg ttctcttgca gtttctggtg gcatctcagg ggaacacaaa
     3301 gctatgtcta ttccccaata taggactttt atgggctcgg cagttagctg ccatgtagaa
     3361 ggctcctaag cagtgggcat ggtgaggttt catctgattg agaaggggga atcctgtgtg
     3421 gaatgttgaa ctttcgccat ggtctccatc gttctgggcg taaattccct gggatcaagt
     3481 aggaaaatgg gcagaactgc ttaggggaat gaaattgcca tttttcgggt gaaacgccac
     3541 acctccaggg tcttaagagt caggctccgg ctgtagtagc tctgatgaaa taggctatcc
     3601 actcgggatg gcttactttt taaaagggta gggggagggg ctggggaaga tctgtcctgc
     3661 accatctgcc taattccttc ctcacagtct gtagccatct gatatcctag gggaaaagga
     3721 aggccagggg ttcacatagg gccccagcga gtttcccagg agttagaggg atgcgaggct
     3781 aacaagttcc aaaaacatct gccccgatgc tctagtgttt ggaggtgggc aggatggaga
     3841 acagtgcctg tttgggggaa aacaggaaat cttgttaggc ttgagtgagg tgtttgcttc
     3901 cttcttgccc agcgctgggt tctctccacc cagtaggttt tctgttgtgg tcccgtggga
     3961 gaggccagac tggattattc ctcctttgct gatcctgggt cacacttcac cagccagggc
     4021 ttttgacgga gacagcaaat aggcctctgc aaatcaatca aaggctgcaa ccctatggcc
     4081 tcttggagac agatgatgac tggcaaggac tagagagcag gagtgcctgg ccaggtcggt
     4141 cctgactctc ctgactctcc atcgctctgt ccaaggagaa cccggagagg ctctgggctg
     4201 attcagaggt tactgcttta tattcgtcca aactgtgtta gtctaggctt aggacagctt
     4261 cagaatctga caccttgcct tgctcttgcc accaggacac ctatgtcaac aggccaaaca
     4321 gccatgcatc tataaaggtc atcatcttct gccaccttta ctgggttcta aatgctctct
     4381 gataattcag agagcattgg gtctgggaag aggtaagagg aacactagaa gctcagcatg
     4441 acttaaacag gttgtagcaa agacagttta tcatcagctc tttcagtggt aaactgtggt
     4501 ttccccaagc tgcacaggag gccagaaacc acaagtatga tgactaggaa gcctactgtc
     4561 atgagagtgg ggagacaggc agcaaagctt atgaaggagg tacagaatat tctttgcgtt
     4621 gtaagacaga atacgggttt aatctagtct aggcaccaga tttttttccc gcttgataag
     4681 gaaagctagc agaaagttta tttaaaccac ttcttgagct ttatcttttt tgacaatata
     4741 ctggagaaac tttgaagaac aagttcaaac tgatacatat acacatattt ttttgataat
     4801 gtaaatacag tgaccatgtt aacctaccct gcactgcttt aagtgaacat actttgaaaa
     4861 agcattatgt tagctgagtg atggccaagt tttttctctg gacaggaatg taaatgtctt
     4921 actggaaatg acaagttttt gcttgatttt tttttttaaa caaaaaatga aatataacaa
     4981 gacaaactta tgataaagta tttgtcttgt agatcaggtg ttttgttttg tttttttaat
     5041 tttaaaatgc aaccctgccc cctccccagc aaagtcacag ctccatttca gtaaaggttg
     5101 gagtcaatat gctctggttg gcaggcaacc ctgtagtcat ggagaaaggt atttcaagat
     5161 ctagtccaat ctttttctag agaaaaagat aatctgaagc tcacaaagat gaagtgactt
     5221 cctcaaaatc acatggttca ggacagaaac aagattaaaa cctggatcca cagactgtgc
     5281 gcctcagaag gaataatcgg taaattaaga attgctactc gaaggtgcca gaatgacaca
     5341 aaggacagaa ttcctttccc agttgttacc ctagcaaggc tagggagggc atgaacacaa
     5401 acataagaac tggtcttcta cactttctct gaatcattta ggtttaagat gtaagtgaac
     5461 aattctttct ttctgccaag aaacaaagtt ttggatgagc ttttatatat ggaacttact
     5521 ccaacaggac tgagggacca aggaaacatg atgggggagg cagagagggc aagagtaaaa
     5581 ctgtagcata gcttttgtca cggtcactag ctgatccctc aggtctgctg caaacacagc
     5641 atggaggaca cagatgactc tttggtgttg gtctttttgt ctgcagtgaa tgttcaacag
     5701 tttgcccagg aactggggga tcatatatgt cttagtggac aggggtctga agtacactgg
     5761 aatttactga gaaacttgtt tgtaaaaact atagttaata attattgcat tttcttacaa
     5821 aaatatattt tggaaaattg tatactgtca attaaagtgt ttttgtgtaa actggttcaa
     5881 aaaaaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_005486               2177 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens target of myb1-like 1 (chicken) (TOM1L1), mRNA.
ACCESSION   NM_005486
VERSION     NM_005486.1  GI:4885638
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Seykora,J.T., Mei,L., Dotto,G.P. and Stein,P.L.
  TITLE     'Srcasm: a novel Src activating and signaling molecule
  JOURNAL   J. Biol. Chem. 277 (4), 2812-2822 (2002)
   PUBMED   11711534
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Seroussi,E., Kedra,D., Kost-Alimova,M., Sandberg-Nordqvist,A.C.,
            Fransson,I., Jacobs,J.F., Fu,Y., Pan,H.Q., Roe,B.A., Imreh,S. and
            Dumanski,J.P.
  TITLE     TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1
            and encode proteins similar to the endosomal proteins HGS and STAM
  JOURNAL   Genomics 57 (3), 380-388 (1999)
   PUBMED   10329004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ010071.1.
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..2177
                     /gene="TOM1L1"
                     /note="synonym: SRCASM"
                     /db_xref="GeneID:10040"
                     /db_xref="MIM:604701"
     CDS             31..1461
                     /gene="TOM1L1"
                     /note="target of myb 1-like 1; Src activating and
                     signaling molecule; target of myb1 (chicken) homolog-like
                     1;
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_component: Golgi stack [goid 0005795] [evidence IEA];
                     go_component: endosome [goid 0005768] [evidence TAS] [pmid
                     10329004];
                     go_component: lysosome [goid 0005764] [evidence TAS] [pmid
                     10329004];
                     go_function: protein transporter activity [goid 0008565]
                     [evidence IEA];
                     go_process: intra-Golgi transport [goid 0006891] [evidence
                     IEA];
                     go_process: intracellular protein transport [goid 0006886]
                     [evidence IEA]"
                     /codon_start=1
                     /product="target of myb1-like 1"
                     /protein_id="NP_005477.1"
                     /db_xref="GI:4885639"
                     /db_xref="GeneID:10040"
                     /db_xref="MIM:604701"
                     /translation="MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINT
                     TQDAPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLV
                     KLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEA
                     ETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRV
                     MSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDL
                     NNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGEL
                     NTMNNQLSGLNFSLPSSDVTNNLKPSLHPQMNLLALENTEIPPFAQRTSQNLTSSHAY
                     DNFLEHSNSVFLQPVSLQTIAAAPSNQSLPPLPSNHPAMTKSDLQPPNYYEVMEFDPL
                     APAVTTEAIYEEIDAHQHKGAQNDGD"
     polyA_signal    2169..2174
                     /gene="TOM1L1"
ORIGIN      
        1 gcactagggg gcccggcctc tggcgctacc atggcgtttg gcaagagtca ccgggatccc
       61 tacgcgacct ccgtgggcca cctcatagaa aaggctacat ttgctggagt tcagactgaa
      121 gattggggcc agttcatgca catctgtgac ataattaaca ctacccagga tgcgccaaaa
      181 gatgcagtga aagctttgaa gaaaaggatt tccaaaaact acaatcataa agaaatccaa
      241 cttaccttgt cacttattga catgtgtgtg cagaactgtg gtccaagttt ccagtctctg
      301 attgtgaaga aggaatttgt taaagagaat ttagttaagc tactgaatcc cagatacaac
      361 ttgccattag acattcagaa tagaatcttg aatttcatta agacttggtc acagggcttc
      421 ccaggaggtg tggatgtaag cgaagtcaaa gaagtatacc tcgacctggt taagaaaggc
      481 gttcagtttc ctccctcaga agcagaggct gaaacagcaa gacaagagac tgctcaaatc
      541 tcatcaaatc ctccaacatc tgtccctact gcaccagctc tttcttctgt aattgctcca
      601 aagaactcga ctgttacatt ggtcccagaa cagattggaa aactgcacag tgaattggat
      661 atggtgaaaa tgaatgtgcg agtgatgtcc gccatattga tggagaatac tcctgggtct
      721 gaaaaccatg aagacataga gcttctgcag aaactctata aaacaggtcg ggagatgcag
      781 gagaggatca tggacctgct tgtggtggtg gagaacgaag atgtaactgt tgagctaatt
      841 caggtgaatg aggatttgaa taatgctatc cttggatatg agaggtttac tagaaaccaa
      901 caaaggattt tggagcaaaa taagaaccag aaggaagcca ccaatactac cagtgagcct
      961 tctgccccat ctcaagatct cctcgaccta agtcccagtc cccggatgcc tagggccact
     1021 ctgggagaac tcaacaccat gaataatcaa ctttcaggct taaatttcag ccttccaagt
     1081 tctgatgtaa caaacaactt aaaacccagt cttcatccac agatgaactt gctagccttg
     1141 gagaatacag agataccccc gtttgcccaa aggaccagcc aaaacctcac ctcaagccac
     1201 gcatatgata attttctgga acattcaaat tcagtgtttc tacagccagt tagtctacaa
     1261 accattgcag cagcaccatc aaaccagagt ctgccacctt tgcccagcaa tcatccagcg
     1321 atgacaaaaa gtgatctcca gccacctaat tactacgagg taatggagtt tgatccctta
     1381 gctcctgctg tcactacaga agctatttat gaagaaattg atgctcacca gcacaaagga
     1441 gctcaaaatg atggtgactg agaagaaagt ggatgatcag ctcactacca catcaaaggt
     1501 gccaactctc taaaacgtag actctgtgca gctttgaagc ctggaagaca atacctacca
     1561 acatgtcaaa gccatggtgg cacatttctg ctataatgaa gattaaatag aataacagtt
     1621 ccaggataac actgattcct gacaacagcg tgagatttca acagaacttg tttggaacaa
     1681 atactcactt aaaacttcag cagaagaaaa attacttagt ccttaggcca accaatttaa
     1741 ctgcagtgtc atgtttcaca ggccttccta catttagaaa tcgtcacaca gctgtgataa
     1801 gagtagatta ttttactatg aaataattct gaatagatga aagcataaaa tgtgagaaac
     1861 tgaatgtatt attcaggaag aatactgagt gccttcattt aactaaagtt gaatgtaaaa
     1921 gtcaatttgc acttctttat aatcctctgg tttagaatta taaattgtta aaaccttgat
     1981 aattgtcatt taattatatt tcaggtgtcc tgaacaggtc actagactct acattgggca
     2041 gcctttaaat atgattcttt gtaatgctaa atagcctttt tttctctttt tactgcaact
     2101 taatatttct atttagaaca cagaaaatga aaatatttag aataagttgt acatttgatg
     2161 acaaataaat cactatt
//

LOCUS       NM_005498               1749 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens adaptor-related protein complex 1, mu 2 subunit
            (AP1M2), mRNA.
ACCESSION   NM_005498
VERSION     NM_005498.3  GI:14916516
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Sugimoto,H., Sugahara,M., Folsch,H., Koide,Y., Nakatsu,F.,
            Tanaka,N., Nishimura,T., Furukawa,M., Mullins,C., Nakamura,N.,
            Mellman,I. and Ohno,H.
  TITLE     Differential recognition of tyrosine-based basolateral signals by
            AP-1B subunit mu1B in polarized epithelial cells
  JOURNAL   Mol. Biol. Cell 13 (7), 2374-2382 (2002)
   PUBMED   12134076
  REMARK    GeneRIF: Results suggest that mu1B interacts with different classes
            of basolateral targeting signals in distinct ways.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Folsch,H., Ohno,H., Bonifacino,J.S. and Mellman,I.
  TITLE     A novel clathrin adaptor complex mediates basolateral targeting in
            polarized epithelial cells
  JOURNAL   Cell 99 (2), 189-198 (1999)
   PUBMED   10535737
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Ohno,H., Tomemori,T., Nakatsu,F., Okazaki,Y., Aguilar,R.C.,
            Foelsch,H., Mellman,I., Saito,T., Shirasawa,T. and Bonifacino,J.S.
  TITLE     Mu1B, a novel adaptor medium chain expressed in polarized
            epithelial cells
  JOURNAL   FEBS Lett. 449 (2-3), 215-220 (1999)
   PUBMED   10338135
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Nakatsu,F., Kadohira,T., Gilbert,D.J., Jenkins,N.A., Kakuta,H.,
            Copeland,N.G., Saito,T. and Ohno,H.
  TITLE     Genomic structure and chromosome mapping of the genes encoding
            clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B
            (Ap1m2)
  JOURNAL   Cytogenet. Cell Genet. 87 (1-2), 53-58 (1999)
   PUBMED   10640811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF020797.2 and BC005021.1.
            On Jul 19, 2001 this sequence version replaced gi:9506796.
            
            Summary: This gene encodes a subunit of the heterotetrameric
            adaptor-related protein comlex 1 (AP-1), which belongs to the
            adaptor complexes medium subunits family. This protein is capable
            of interacting with tyrosine-based sorting signals.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1749
                     /gene="AP1M2"
                     /note="synonyms: MU1B, MU-1B, HSMU1B"
                     /db_xref="GeneID:10053"
                     /db_xref="MIM:607309"
     CDS             85..1356
                     /gene="AP1M2"
                     /note="AP-mu chain family member mu1B; clathrin-associated
                     adaptor medium chain mu2; clathrin coat assembly protein
                     AP47 2; clathrin coat associated protein AP47 2; golgi
                     adaptor AP-1 47 kDa protein; HA1 47 kDa subunit 2;
                     clathrin assembly protein complex 1 medium chain 2;
                     go_component: coated pit [goid 0005905] [evidence IEA];
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     IEA];
                     go_component: clathrin vesicle coat [goid 0030125]
                     [evidence IEA];
                     go_process: endocytosis [goid 0006897] [evidence IEA];
                     go_process: protein targeting [goid 0006605] [evidence
                     TAS] [pmid 10338135];
                     go_process: vesicle targeting [goid 0006903] [evidence
                     TAS] [pmid 10338135]"
                     /codon_start=1
                     /product="adaptor-related protein complex 1, mu 2 subunit"
                     /protein_id="NP_005489.2"
                     /db_xref="GI:9506797"
                     /db_xref="GeneID:10053"
                     /db_xref="MIM:607309"
                     /translation="MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEG
                     ALAPLLSHGQVHFLWIKHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEES
                     IRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWR
                     SEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRV
                     LFELTGRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPL
                     IWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKY
                     VPERNVVIWSIKSFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQV
                     RYMKIIEKSGYQALPWVRYITQSGDYQLRTS"
     polyA_signal    1732..1737
                     /gene="AP1M2"
     polyA_site      1749
                     /gene="AP1M2"
                     /evidence=experimental
ORIGIN      
        1 ggcgcttccg caggaagaag gaagcggcgc cgccatcgcc tcccggcgct ccctccccga
       61 ctcctaagtc cttcggccgc caccatgtcc gcctcggctg tcttcattct ggacgttaag
      121 ggcaagccat tgatcagccg caactacaag ggcgatgtgg ccatgagcaa gattgagcac
      181 ttcatgcctt tgctggtaca gcgggaggag gaaggcgccc tggccccgct gctgagccac
      241 ggccaggtcc acttcctatg gatcaaacac agcaacctct acttggtggc caccacatcg
      301 aagaatgcca atgcctccct ggtgtactcc ttcctgtata agacaataga ggtattctgc
      361 gaatacttca aggagctgga ggaggagagc atccgggaca actttgtcat cgtctacgag
      421 ttgctggacg agctcatgga ctttggcttc ccgcagacca ccgacagcaa gatcctgcag
      481 gagtacatca ctcagcagag caacaagctg gagacgggca agtcacgggt gccacccact
      541 gtcaccaacg ctgtgtcctg gcgctccgag ggtatcaagt ataagaagaa cgaggtcttc
      601 attgatgtca tagagtctgt caacctgctg gtcaatgcca acggcagcgt ccttctgagc
      661 gaaatcgtcg gtaccatcaa gctcaaggtg tttctgtcag gaatgccaga gctgcggctg
      721 ggcctcaatg accgcgtgct cttcgagctc actggccgca gcaagaacaa atcagtagag
      781 ctggaggatg taaaattcca ccagtgcgtg cggctctctc gctttgacaa cgaccgcacc
      841 atctccttca tcccgcctga tggtgacttt gagctcatgt cataccgcct cagcacccag
      901 gtcaagccac tgatctggat tgagtctgtc attgagaagt tctcccacag ccgcgtggag
      961 atcatggtca aggccaaggg gcagtttaag aaacagtcag tggccaacgg tgtggagata
     1021 tctgtgcctg tacccagcga tgccgactcc cccagattca agaccagtgt gggcagcgcc
     1081 aagtatgtgc cggagagaaa cgtcgtgatt tggagtatta agtctttccc ggggggcaag
     1141 gagtacttga tgcgagccca ctttggcctc cccagtgtgg aaaaggaaga ggtggagggc
     1201 cggcccccca tcggggtcaa gtttgagatc ccctacttca ccgtctctgg gatccaggtc
     1261 cgatacatga agatcattga gaaaagtggt taccaggccc tgccctgggt tcgctacatc
     1321 acccagagtg gcgattacca acttcgtacc agctagaagg gagaagagat gggggcttga
     1381 acacggggct tccttacagc cccggatgca gattttagag ggagggcagg tgcgggctgt
     1441 gtgtgtctgt gtgagggcag gtcctggact tggcagtttc ttgctcccag cacccgcccc
     1501 ttcctcacct cttccttatt ccataggctg ggagagaaac tctctgcttc cctcgccctt
     1561 ggagctttcc ccatccccct gattttatat gaagaaatag aagaggggct tgaagtcccc
     1621 ctcgcgagtg ccttcttgca attacctgcc ttagcgggtg ttgcgggtcc ctccttcaca
     1681 gccgctgagc ccagaggtcc cgctggcccc tcctctgaat tttaggatgt cattaaaaag
     1741 atgaatcta
//

LOCUS       NM_005573               2882 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens lamin B1 (LMNB1), mRNA.
ACCESSION   NM_005573
VERSION     NM_005573.2  GI:27436949
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Maske,C.P., Hollinshead,M.S., Higbee,N.C., Bergo,M.O., Young,S.G.
            and Vaux,D.J.
  TITLE     A carboxyl-terminal interaction of lamin B1 is dependent on the
            CAAX endoprotease Rce1 and carboxymethylation
  JOURNAL   J. Cell Biol. 162 (7), 1223-1232 (2003)
   PUBMED   14504265
  REMARK    GeneRIF: organization of the nuclear envelope and lamina is
            dependent on a mechanism involving the methylation of lamin B1
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Ito,S., Eda,H., Ban,F. and Yanagi,K.
  TITLE     Epstein-Barr virus nuclear antigen-1 colocalizes with lamin B1 in
            the nucleoplasm and along the nuclear rim
  JOURNAL   Arch. Virol. 148 (8), 1633-1642 (2003)
   PUBMED   12898336
  REMARK    GeneRIF: colocalizes with lamin B1 in the nucleoplasm and around
            the nuclear rim during S-phase of cells transfected with EBNA-1 in
            the absence of EBV plasmids.
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   de Noronha,C.M., Sherman,M.P., Lin,H.W., Cavrois,M.V., Moir,R.D.,
            Goldman,R.D. and Greene,W.C.
  TITLE     Dynamic disruptions in nuclear envelope architecture and integrity
            induced by HIV-1 Vpr
  JOURNAL   Science 294 (5544), 1105-1108 (2001)
   PUBMED   11691994
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Worman,H.J. and Courvalin,J.C.
  TITLE     The inner nuclear membrane
  JOURNAL   J. Membr. Biol. 177 (1), 1-11 (2000)
   PUBMED   10960149
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Gruenbaum,Y., Wilson,K.L., Harel,A., Goldberg,M. and Cohen,M.
  TITLE     Review: nuclear lamins--structural proteins with fundamental
            functions
  JOURNAL   J. Struct. Biol. 129 (2-3), 313-323 (2000)
   PUBMED   10806082
REFERENCE   6  (bases 1 to 2882)
  AUTHORS   Vodicka,M.A., Koepp,D.M., Silver,P.A. and Emerman,M.
  TITLE     HIV-1 Vpr interacts with the nuclear transport pathway to promote
            macrophage infection
  JOURNAL   Genes Dev. 12 (2), 175-185 (1998)
   PUBMED   9436978
REFERENCE   7  (bases 1 to 2882)
  AUTHORS   Lin,F. and Worman,H.J.
  TITLE     Expression of nuclear lamins in human tissues and cancer cell lines
            and transcription from the promoters of the lamin A/C and B1 genes
  JOURNAL   Exp. Cell Res. 236 (2), 378-384 (1997)
   PUBMED   9367621
REFERENCE   8  (bases 1 to 2882)
  AUTHORS   Broers,J.L., Machiels,B.M., Kuijpers,H.J., Smedts,F., van den
            Kieboom,R., Raymond,Y. and Ramaekers,F.C.
  TITLE     A- and B-type lamins are differentially expressed in normal human
            tissues
  JOURNAL   Histochem. Cell Biol. 107 (6), 505-517 (1997)
   PUBMED   9243284
REFERENCE   9  (bases 1 to 2882)
  AUTHORS   Wydner,K.L., McNeil,J.A., Lin,F., Worman,H.J. and Lawrence,J.B.
  TITLE     Chromosomal assignment of human nuclear envelope protein genes
            LMNA, LMNB1, and LBR by fluorescence in situ hybridization
  JOURNAL   Genomics 32 (3), 474-478 (1996)
   PUBMED   8838815
REFERENCE   10 (bases 1 to 2882)
  AUTHORS   Lin,F. and Worman,H.J.
  TITLE     Structural organization of the human gene (LMNB1) encoding nuclear
            lamin B1
  JOURNAL   Genomics 27 (2), 230-236 (1995)
   PUBMED   7557986
REFERENCE   11 (bases 1 to 2882)
  AUTHORS   Pollard,K.M., Chan,E.K., Grant,B.J., Sullivan,K.F., Tan,E.M. and
            Glass,C.A.
  TITLE     In vitro posttranslational modification of lamin B cloned from a
            human T-cell line
  JOURNAL   Mol. Cell. Biol. 10 (5), 2164-2175 (1990)
   PUBMED   2325650
REFERENCE   12 (bases 1 to 2882)
  AUTHORS   Muller,W.E., Okamoto,T., Reuter,P., Ugarkovic,D. and Schroder,H.C.
  TITLE     Functional characterization of Tat protein from human
            immunodeficiency virus. Evidence that Tat links viral RNAs to
            nuclear matrix
  JOURNAL   J. Biol. Chem. 265 (7), 3803-3808 (1990)
   PUBMED   2406262
REFERENCE   13 (bases 1 to 2882)
  AUTHORS   Muller,W.E., Wenger,R., Reuter,P., Renneisen,K. and Schroder,H.C.
  TITLE     Association of Tat protein and viral mRNA with nuclear matrix from
            HIV-1-infected H9 cells
  JOURNAL   Biochim. Biophys. Acta 1008 (2), 208-212 (1989)
   PUBMED   2544227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M34458.1 and AU134245.1.
            On Dec 31, 2002 this sequence version replaced gi:5031876.
            
            Summary: The nuclear lamina consists of a two-dimensional matrix of
            proteins located next to the inner nuclear membrane. The lamin
            family of proteins make up the matrix and are highly conserved in
            evolution. During mitosis, the lamina matrix is reversibly
            disassembled as the lamin proteins are phosphorylated. Lamin
            proteins are thought to be involved in nuclear stability, chromatin
            structure and gene expression. Vertebrate lamins consist of two
            types, A and B. This gene encodes one of the two B type proteins,
            B1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3-q31.1"
     gene            1..2882
                     /gene="LMNB1"
                     /note="synonyms: LMN, LMN2, LMNB"
                     /db_xref="GeneID:4001"
                     /db_xref="MIM:150340"
     CDS             369..2129
                     /gene="LMNB1"
                     /note="go_component: nucleus [goid 0005634] [evidence
                     IEA];
                     go_component: lamin filament [goid 0005638] [evidence TAS]
                     [pmid 7557986];
                     go_function: structural molecule activity [goid 0005198]
                     [evidence TAS] [pmid 7557986]"
                     /codon_start=1
                     /product="lamin B1"
                     /protein_id="NP_005564.1"
                     /db_xref="GI:5031877"
                     /db_xref="GeneID:4001"
                     /db_xref="MIM:150340"
                     /translation="MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLA
                     VYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAK
                     LQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLE
                     GDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINE
                     TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENAR
                     LSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLLAKEKDN
                     SRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSP
                     SPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVD
                     GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTIWAANAGVTAS
                     PPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEAAGVVVE
                     EELFHQQGTPRASNRSCAIM"
     polyA_signal    2861..2866
                     /gene="LMNB1"
     polyA_site      2882
                     /gene="LMNB1"
                     /evidence=experimental
ORIGIN      
        1 gtgcagcctg agaggaaaca aagtgctgcg agcaggagac ggcggcggcg cgaaccctgc
       61 tgggcctcca gtcaccctcg tcttgcattt tcccgcgtgc gtgtgtgagt gggtgtgtgt
      121 gttttcttac aaagggtatt tcgcgatcga tcgattgatt cgtagttccc ccccgcgcgc
      181 ctttgccctt tgtgctgtaa tcgagctccc gccatcccag gtgcttctcc gttcctctaa
      241 acgccagcgt ctggacgtga gcgcaggtcg ccggtttgtg ccttcggtcc ccgcttcgcc
      301 ccctgccgtc ccctccttat cacggtcccg ctcgcggcct cgccgccccg ctgtctccgc
      361 cgcccgccat ggcgactgcg acccccgtgc cgccgcggat gggcagccgc gctggcggcc
      421 ccaccacgcc gctgagcccc acgcgcctgt cgcggctcca ggagaaggag gagctgcgcg
      481 agctcaatga ccggctggcg gtgtacatcg acaaggtgcg cagcctggag acggagaaca
      541 gcgcgctgca gctgcaggtg acggagcgcg aggaggtgcg cggccgtgag ctcaccggcc
      601 tcaaggcgct ctacgagacc gagctggccg acgcgcgacg cgcgctcgac gacacggccc
      661 gcgagcgcgc caagctgcag atcgagctgg gcaagtgcaa ggcggaacac gaccagctgc
      721 tcctcaacta tgctaagaag gaatctgatc ttaatggcgc ccagatcaag cttcgagaat
      781 atgaagcagc actgaattcg aaagatgcag ctcttgctac tgcacttggt gacaaaaaaa
      841 gtttagaggg agatttggag gatctgaagg atcagattgc ccagttggaa gcctccttag
      901 ctgcagccaa aaaacagtta gcagatgaaa ctttacttaa agtagatttg gagaatcgtt
      961 gtcagagcct tactgaggac ttggagtttc gcaaaagcat gtatgaagag gagattaacg
     1021 agaccagaag gaagcatgaa acgcgcttgg tagaggtgga ttctgggcgt caaattgagt
     1081 atgagtacaa gctggcgcaa gcccttcatg agatgagaga gcaacatgat gcccaagtga
     1141 ggctgtataa ggaggagctg gagcagactt accatgccaa acttgagaat gccagactgt
     1201 catcagagat gaatacttct actgtcaaca gtgccaggga agaactgatg gaaagccgca
     1261 tgagaattga gagcctttca tcccagcttt ctaatctaca gaaagagtct agagcatgtt
     1321 tggaaaggat tcaagaatta gaggacttgc ttgctaaaga aaaagacaac tctcgtcgca
     1381 tgctgacaga caaagagaga gagatggcgg aaataaggga tcaaatgcag caacagctga
     1441 atgactatga acagcttctt gatgtaaagt tagccctgga catggaaatc agtgcttaca
     1501 ggaaactctt agaaggcgaa gaagagaggt tgaagctgtc tccaagccct tcttcccgtg
     1561 tgacagtatc ccgagcatcc tcaagtcgta gtgtacgtac aactagagga aagcggaaga
     1621 gggttgatgt ggaagaatca gaggcgagta gtagtgttag catctctcat tccgcctcag
     1681 ccactggaaa tgtttgcatc gaagaaattg atgttgatgg gaaatttatc cgcttgaaga
     1741 acacttctga acaggatcaa ccaatgggag gctgggagat gatcagaaaa attggagaca
     1801 catcagtcag ttataaatat acctcaagat atgtgctgaa ggcaggccag actgttacaa
     1861 tttgggctgc aaacgctggt gtcacagcca gccccccaac tgacctcatc tggaagaacc
     1921 agaactcgtg gggcactggc gaagatgtga aggttatatt gaaaaattct cagggagagg
     1981 aggttgctca aagaagtaca gtctttaaaa caaccatacc tgaagaagag gaggaggagg
     2041 aagaagcagc tggagtggtt gttgaggaag aacttttcca ccagcaggga accccaagag
     2101 catccaatag aagctgtgca attatgtaaa attttcaact gtcttcctca aaataaagaa
     2161 gtatggtaat ccttacctgt atacagtgca gagccttctc agaagcacag aatattttta
     2221 tatttccttt atgtgaattt ttaagctgca aatctgatgg ccttaatttc ctttttgaca
     2281 ctgaaagttt tgtaaaagaa atcatgtcca tacactttgt tgcaagatgt gaattattga
     2341 cactgaactt aataactgtg tactgttcgg aaggggttcc tcaaattttt tgactttttt
     2401 tgtatgtgtg ttttttcttt ttttttaagt tcttatgagg aggggagggt aaataaacca
     2461 ctgtgcgtct tggtgtaatt tgaagattgc cccatctaga ctagcaatct cttcattatt
     2521 ctctgctata tataaaacgg tgctgtgagg gaggggaaaa gcatttttca atatattgaa
     2581 cttttgtact gaattttttt gtaataagca atcaaggtta taattttttt taaaatagaa
     2641 attttgtaag aaggcaatat taacctaatc accatgtaag cactctggat gatggattcc
     2701 acaaaacttg gttttatggt tacttcttct cttagattct taattcatga ggagggtggg
     2761 ggagggaggt ggagggaggg aagggtttct ctattaaaat gcattcgttg tgttttttaa
     2821 gatagtgtaa cttgcttaaa tttcttatgt gacattaaca aataaaaaag ctcttttaat
     2881 at
//

LOCUS       NM_005597               2185 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens nuclear factor I/C (CCAAT-binding transcription
            factor) (NFIC), transcript variant 1, mRNA.
ACCESSION   NM_005597
VERSION     NM_005597.2  GI:45505148
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Nogues,G., Kadener,S., Cramer,P., Bentley,D. and Kornblihtt,A.R.
  TITLE     Transcriptional activators differ in their abilities to control
            alternative splicing
  JOURNAL   J. Biol. Chem. 277 (45), 43110-43114 (2002)
   PUBMED   12221105
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Wenzelides,S., Altmann,H., Wendler,W. and Winnacker,E.L.
  TITLE     CTF5--a new transcriptional activator of the NFI/CTF family
  JOURNAL   Nucleic Acids Res. 24 (12), 2416-2421 (1996)
   PUBMED   8710515
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Blau,J., Xiao,H., McCracken,S., O'Hare,P., Greenblatt,J. and
            Bentley,D.
  TITLE     Three functional classes of transcriptional activation domain
  JOURNAL   Mol. Cell. Biol. 16 (5), 2044-2055 (1996)
   PUBMED   8628270
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Santoro,C., Mermod,N., Andrews,P.C. and Tjian,R.
  TITLE     A family of human CCAAT-box-binding proteins active in
            transcription and DNA replication: cloning and expression of
            multiple cDNAs
  JOURNAL   Nature 334 (6179), 218-224 (1988)
   PUBMED   3398920
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC012120.1, BI253961.1 and
            BE887429.1.
            On Mar 17, 2004 this sequence version replaced gi:10835080.
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2185
                     /gene="NFIC"
                     /note="synonyms: CTF, NFI, CTF5, NF-I, MGC20153"
                     /db_xref="GeneID:4782"
                     /db_xref="MIM:600729"
     CDS             63..1349
                     /gene="NFIC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CCAAT-binding transcription factor;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 7590749];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 8710515];
                     go_process: DNA replication [goid 0006260] [evidence IEA];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence TAS] [pmid 8710515];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="nuclear factor I/C isoform 1"
                     /protein_id="NP_005588.2"
                     /db_xref="GI:45505149"
                     /db_xref="GeneID:4782"
                     /db_xref="MIM:600729"
                     /translation="MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
                     HEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAP
                     GCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHP
                     VLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQE
                     SFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSS
                     SGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSP
                     FNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHT
                     AIRYPPHLNPQDPLKDLVSLACDPASQQPGPSWYLG"
ORIGIN      
        1 aatgactcag taagttcagc gcgcccgctc cggccggccc tgcgcctccc gccgcgcccg
       61 ggatgtattc gtccccgctc tgcctcaccc aggatgagtt ccacccgttc atcgaggccc
      121 tgctgcctca cgtccgcgcc ttcgcctaca cctggttcaa cctgcaggcg cggaagcgca
      181 agtacttcaa gaagcacgag aagcggatgt cgaaggacga ggagcgtgcg gtcaaggacg
      241 agctgctggg cgagaagccc gaggtcaagc agaagtgggc gtcgcggctg ctggccaagc
      301 tgcgcaagga catccggccc gagtgccgcg aggacttcgt gctgagcatc accggcaaga
      361 aggcgccggg ctgcgtgctc tccaaccccg accagaaggg caagatgcgg cgcatcgact
      421 gtctccggca ggcggacaag gtgtggcggc tggacctggt catggtcatc ctgttcaagg
      481 gcatcccgct ggagagcacc gacggcgagc gcctggtcaa ggctgcgcag tgcggtcacc
      541 cggtcctgtg cgtgcagccg caccacattg gcgtggccgt caaggagctg gacctctacc
      601 tggcctactt cgtgcgtgag cgagatgcag agcaaagcgg cagtccccgg acagggatgg
      661 gctctgacca ggaggacagc aagcccatca cgctggacac gaccgacttc caggagagct
      721 ttgtcacctc cggcgtgttc agcgtcactg agctcatcca agtgtcccgg acacccgtgg
      781 tgactggaac aggacccaac ttctccctgg gggagctgca ggggcacctg gcatacgacc
      841 tgaacccagc cagcactggc ctcagaagaa cgctgcccag cacctcctcc agtgggagca
      901 agcggcacaa atcgggctcg atggaggaag acgtggacac gagccctggc ggcgattact
      961 acacttcgcc cagctcgccc acgagtagca gccgcaactg gacggaggac atggaaggag
     1021 gcatctcgtc cccggtgaag aagacagaga tggacaagtc accattcaac agcccgtccc
     1081 cccaggactc tccccgcctc tccagcttca cccagcacca ccggcccgtc atcgccgtgc
     1141 acagcgggat cgcccggagc ccacacccgt cctccgctct gcatttccct acgacgtcca
     1201 tcctacccca gacggcctcc acctacttcc cccacacggc catccgctac ccacctcatc
     1261 tcaaccccca ggacccgctc aaagatcttg tctcgctggc ctgcgaccca gccagccagc
     1321 aacctggacc gtcctggtat ctgggatagc aaaggtcttc ttccctcgcc ccttctccat
     1381 cgtcccagga atcccagggg gcagcacagc cggcccccgg cccacgtttt cggtggaaaa
     1441 ttagagtgaa caagaacacc cctgccgact cccagcccgg ccaaaaagac aaaacacata
     1501 gacgcacaca ctcaggagga aaagaaaaaa caaaggcaga agaagaagaa gaagaaataa
     1561 aaacccaccc aagcaagaag acaaaaggta aagacgcaac gtttccaact ctcgggacgc
     1621 caaggccgca ggactggagg gccaggcccc gccaccccca cgggagaccc gggacagggc
     1681 gtcttcctaa gttattcatc tcctctccgc ctgctgctcg ggaaggacag acgccggccg
     1741 cccgcccgcg ccccggaggc cctggctctg tccggagacc aggtgagcac agcctggagc
     1801 ctgtgcccag ggccgacagg cgcgacaccc agcaaggcca cctctccccg ggcccccgcg
     1861 cctctgccgg acacggaccg gcccctcagc ccccaccgag gacgcagcca ctggggggaa
     1921 agggagacac agcggacccc ggccgggcag cggagaccgc agaggcgggc agggtggggc
     1981 aggcgagtgg tgtcgcgggg gtgcgtggcg cttgcgagcc ctggccaggg gaggaagtga
     2041 ggcccaggca cctgctgccc ctcgaggggg ccctgcctgc cgcggggcct ccccacaagc
     2101 ccctcccaaa gcgccggccg actcgctgtc tcgctgggga ctctttcagc cctcgcgccc
     2161 gcccgtttgg gaggagaagt ctcta
//

LOCUS       NM_005646               5130 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens TAR (HIV) RNA binding protein 1 (TARBP1), mRNA.
ACCESSION   NM_005646
VERSION     NM_005646.2  GI:19743835
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5130)
  AUTHORS   Yedavalli,V.S., Benkirane,M. and Jeang,K.T.
  TITLE     Tat and trans-activation-responsive (TAR) RNA-independent induction
            of HIV-1 long terminal repeat by human and murine cyclin T1
            requires Sp1
  JOURNAL   J. Biol. Chem. 278 (8), 6404-6410 (2003)
   PUBMED   12458222
  REMARK    GeneRIF: induces induction of HIV-1 long terminal repeat by human
            and murine cyclin T1 and requires Sp1.
REFERENCE   2  (bases 1 to 5130)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Identification of a group of cellular cofactors that stimulate the
            binding of RNA polymerase II and TRP-185 to human immunodeficiency
            virus 1 TAR RNA
  JOURNAL   J. Biol. Chem. 271 (8), 4201-4208 (1996)
   PUBMED   8626763
REFERENCE   3  (bases 1 to 5130)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     The cellular factor TRP-185 regulates RNA polymerase II binding to
            HIV-1 TAR RNA
  JOURNAL   EMBO J. 14 (23), 5995-6009 (1995)
   PUBMED   8846792
REFERENCE   4  (bases 1 to 5130)
  AUTHORS   Wu-Baer,F., Sigman,D. and Gaynor,R.B.
  TITLE     Specific binding of RNA polymerase II to the human immunodeficiency
            virus trans-activating region RNA is regulated by cellular
            cofactors and Tat
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (16), 7153-7157 (1995)
   PUBMED   7638159
REFERENCE   5  (bases 1 to 5130)
  AUTHORS   Sheline,C.T., Milocco,L.H. and Jones,K.A.
  TITLE     Two distinct nuclear transcription factors recognize loop and bulge
            residues of the HIV-1 TAR RNA hairpin
  JOURNAL   Genes Dev. 5 (12B), 2508-2520 (1991)
   PUBMED   1752441
REFERENCE   6  (bases 1 to 5130)
  AUTHORS   Wu,F., Garcia,J., Sigman,D. and Gaynor,R.
  TITLE     tat regulates binding of the human immunodeficiency virus
            trans-activating region RNA loop-binding protein TRP-185
  JOURNAL   Genes Dev. 5 (11), 2128-2140 (1991)
   PUBMED   1936997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U38847.1 and AA714641.1.
            On Mar 26, 2002 this sequence version replaced gi:5032156.
            
            Summary: HIV-1, the causative agent of acquired immunodeficiency
            syndrome (AIDS), contains an RNA genome that produces a
            chromosomally integrated DNA during the replicative cycle.
            Activation of HIV-1 gene expression by the transactivator Tat is
            dependent on an RNA regulatory element (TAR) located downstream of
            the transcription initiation site. This element forms a stable
            stem-loop structure and can be bound by either the protein encoded
            by this gene or by RNA polymerase II. This protein may act to
            disengage RNA polymerase II from TAR during transcriptional
            elongation. Alternatively spliced transcripts of this gene may
            exist, but their full-length natures have not been determined.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..5130
                     /gene="TARBP1"
                     /note="synonyms: TRP185, TRP-185, FLJ30482"
                     /db_xref="GeneID:6894"
                     /db_xref="MIM:605052"
     CDS             1..4866
                     /gene="TARBP1"
                     /note="TAR RNA loop binding protein; TAR (HIV) RNA-binding
                     protein 1;
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     8846792];
                     go_function: RNA binding [goid 0003723] [evidence TAS]
                     [pmid 8846792];
                     go_function: RNA methyltransferase activity [goid 0008173]
                     [evidence IEA];
                     go_process: RNA processing [goid 0006396] [evidence IEA];
                     go_process: regulation of transcription from Pol II
                     promoter [goid 0006357] [evidence TAS] [pmid 8846792]"
                     /codon_start=1
                     /product="TAR RNA binding protein 1"
                     /protein_id="NP_005637.2"
                     /db_xref="GI:19743836"
                     /db_xref="GeneID:6894"
                     /db_xref="MIM:605052"
                     /translation="MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLLQRLE
                     DEEARGSGGAGALPEAAREVAAGYLVPLLRSLRGRPAGGPDPSLQPRHRRRVLRANSS
                     ALRSCVRLAGRPQLAAALAEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLL
                     ERVAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPG
                     ASLGSGRVEEKLLVLSALAEKLLPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQA
                     DALTRKRARYLLQRAVEVSAELGADCTCGPQEGNGPSLFWWSERKKDELLKFWENYIL
                     IMETLEGNQIHVIKPVLPKLNNLFEYAVSEENGCWLFHPSWHMCIYKRMFESENKILS
                     KEGVIHFLELYETKILPFSPEFSEFIIGPLMDALSESSLYSRSPGQPIGSCSPLGLKL
                     QKFLVTYISLLPEEIKSSFLLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGL
                     LALRDVIHCTMITHQILLRGAAQCYLLQTAMNLLDVEKVSLSDVSTFLMSLRQEESLG
                     RGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKTSLNAYVKSIVQEYVKSSAWETGEN
                     CFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLRIFLDPLLDVLMKFSTNAY
                     MPLLKTDRCLQLLLKLLNTCRLKGSSAQDDEVSTVLQNFFMSTTESISEFILRRLTMN
                     ELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVISLLKNASIQHLQEMDSGQ
                     EPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHA
                     EEQSSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSFLLKKYHTLIPTTGSEI
                     LEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLTSSESLCIESFDM
                     AWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKEIMYKIIEMSA
                     IKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYSELILEACIFGTVFRRDQRLVQD
                     VQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIEDLAIKLL
                     DKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGFTNNQ
                     ASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICTFLAVLSHLDIITQNIP
                     EKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSL
                     HQVESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITID
                     KFTRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAEWTDVQKKIIP
                     WNSRVSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVV
                     GSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDL
                     TQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTR
                     QQLLSHGDTKP"
     polyA_signal    5041..5046
                     /gene="TARBP1"
     polyA_site      5065
                     /gene="TARBP1"
                     /evidence=experimental
     polyA_signal    5076..5081
                     /gene="TARBP1"
     polyA_site      5095
                     /gene="TARBP1"
                     /evidence=experimental
     polyA_signal    5102..5107
                     /gene="TARBP1"
     polyA_site      5130
                     /gene="TARBP1"
                     /evidence=experimental
ORIGIN      
        1 atggagtggg tgctcgcgga agcgctgctc tcgcagagcc gggacccccg ggccctgctt
       61 ggggcgctgt gccaagggga ggcatccgcg gagcgcgtgg agacgctgcg cttccttctg
      121 cagcggctcg aggacgagga ggcgcgcggc agcgggggcg caggcgcgct cccggaggcg
      181 gcgcgcgagg tggctgcagg gtacctcgtg ccactgctgc ggagcctgcg cggacgcccc
      241 gcgggcggcc cggaccccag tctgcagcct cgccaccgac ggcgcgtgct gagggcgaac
      301 agttcggccc tgcgctcgtg cgtccgcctg gccgggcgtc cgcagctggc ggccgcgctg
      361 gctgaggagg cgctgcgcga tctgctcgcc gggtggcgcg cgcctggcgc cgaggctgcc
      421 gtggaagtgc tagcagccgt cgggccatgt ttgcggcccc gcgaggacgg gccgctactg
      481 gagcgcgtgg cggggaccgc cgtcgccctg gcgctgggcg ggggcgggga cggggatgag
      541 gccgggcctg ccgaggacgc ggcggcgctg gtggccgggc gactgctgcc agtgctggtc
      601 caatgtggcg gggcggcgct gcgggccgtg tggggcgggc tggccgcgcc tggggcgtcc
      661 ctggggtccg gccgcgtaga ggagaagctg ctggtcctga gcgccctggc cgagaagctg
      721 ttgcccgagc ccggcggcga ccgcgcccgc ggcgcgcgcg aggcgggccc ggacgcccgg
      781 cgctgctggc gcttctggag gacggtgcag gcggggctgg gccaggcgga cgccctgacg
      841 cgcaagcgag cgcgctacct gctgcagagg gcggtggagg tgtcggcgga gctgggggcc
      901 gactgcacct gcgggcccca ggaaggaaac ggcccaagtc tgttttggtg gtctgagagg
      961 aaaaaagatg agcttctaaa gttttgggaa aattatattt taattatgga gactttagaa
     1021 ggaaatcaga tacatgttat aaagccagtt ttaccaaagc taaacaatct gtttgaatat
     1081 gcggtgtcag aggaaaatgg atgttggctc tttcacccat cctggcatat gtgtatttat
     1141 aaaagaatgt ttgaaagtga aaacaaaatc ctgtccaaag aaggtgttat ccattttttg
     1201 gagctgtatg aaacaaagat tcttccattt tcaccagaat tttctgagtt tattattgga
     1261 ccattaatgg atgcgctttc agagagctct ctgtatagca ggtccccagg ccagccaata
     1321 ggaagctgtt ctccattggg actgaaatta cagaagtttt tagtcactta tatttctctt
     1381 cttccagaag aaataaagag tagcttccta ttgaagttta ttcggaagat gacaagtagg
     1441 cattggtgtg ctgttcccat tttgtttcta tctaaggctt tggcaaatgt cccaagacat
     1501 aaggccctgg gtatagatgg gcttcttgct ctcagggatg ttattcattg cactatgatc
     1561 acacatcaga ttctcctgag aggggcagcc caatgctacc ttcttcaaac agctatgaat
     1621 ttgctagatg tggagaaagt gtcactttct gatgtctcaa cttttctcat gtctctgaga
     1681 caagaggaat ccttaggacg aggaacttca ttgtggacag agctgtgtga ctggctacgt
     1741 gttaatgaaa gctattttaa gccatcccct acgtgtagct ccattggact tcacaagaca
     1801 tctttaaatg cttatgtaaa gagcattgtt caagagtatg ttaagtcatc tgcttgggaa
     1861 acaggagaaa actgctttat gcctgattgg tttgaagcca agcttgtttc tctgatggtc
     1921 ttgctggctg tggatgtgga aggaatgaag actcagtata gcggaaagca gagaacagag
     1981 aatgtattgc ggatattctt agaccctctt ctggatgtgc ttatgaagtt tagtaccaat
     2041 gcctacatgc ccttgctgaa gactgacaga tgcctccagc tgctgttgaa gctgttgaac
     2101 acatgcaggt tgaaaggttc cagtgcccaa gatgatgagg tgtctactgt tcttcagaac
     2161 tttttcatgt ctactacaga gagcatttct gaatttattc tcagaagact tactatgaat
     2221 gagctaaata gtgtttcaga tctggatcgt tgccatttat acctgatggt gttaactgag
     2281 cttataaatc tgcatttgaa ggttgggtgg aaaaggggta accctatctg gagagttatt
     2341 tctcttttga aaaatgcatc cattcagcat cttcaagaga tggacagtgg acaggagcca
     2401 acagttggaa gtcagattca gagagtagtg agcatggctg ccttggccat ggtgtgtgag
     2461 gccatagacc agaagcctga gctgcagctg gactctctcc atgctgggcc cctggaaagc
     2521 ttcctttcct ctcttcagct caatcagacg ctgcagaagc cccacgcaga ggagcagagc
     2581 agttatgctc accccttgga gtgcagcagt gttttggaag aatcgtcatc ttcccaagga
     2641 tggggaaaaa tagttgcaca atatattcat gatcaatggg tgtgcctctc tttcctgttg
     2701 aaaaaatatc acacccttat accaaccaca gggagtgaaa ttctggaacc gtttctacct
     2761 gccgttcaga tgccaataag gactttgcag tctgcactag aagccctcac agttctttct
     2821 tctgatcaag ttttaccagt gttccattgc ttgaaagtgt tggttcccaa gcttctgact
     2881 tcctctgaat cactctgcat agagtctttt gacatggcgt ggaaaattat atcttcttta
     2941 agcaacactc agctgatatt ctgggctaat ttaaaagctt ttgttcagtt tgtttttgat
     3001 aacaaagttc ttaccattgc tgccaaaatc aagggccagg catatttcaa aataaaagag
     3061 attatgtaca agataattga aatgtctgct ataaagactg gagtcttcaa tacactgata
     3121 agttactgct gtcagtcttg gatagtgtct gcttcaaatg tgtcccaagg atctttatca
     3181 agtgctaaaa attatagcga acttatcctt gaggcttgta tatttggaac tgtgtttagg
     3241 cgtgatcaaa gacttgttca ggatgtacag accttcatag aaaaccttgg acatgactgt
     3301 gcggcaaata ttgttatgga aaatactaag agagaagacc attatgtgag aatttgtgct
     3361 gtcaaattcc tgtgtttatt agatggctcc aatatgtccc acaagttgtt tattgaggat
     3421 cttgcaatca agctattaga taaagatgaa ttagtgtcca agtccaaaaa acgctactat
     3481 gtgaattctc tacagcacag agtgaaaaac cgagtgtggc agactctgct ggtacttttc
     3541 cctagacttg accagaattt cttgaatgga attattgaca ggattttcca ggctggtttc
     3601 accaacaatc aagcatccat aaaatatttt atagaatgga ttattatatt gattcttcat
     3661 aaattccctc aatttcttcc aaagttctgg gattgttttt cttatggtga agaaaatctt
     3721 aaaacaagca tttgtacgtt tttagcagtt ttatcacatt tagacattat tactcaaaat
     3781 attccagaaa agaaactaat tctgaagcaa gcccttatag ttgtgctgca gtggtgtttc
     3841 aatcacaatt ttagtgttcg actgtatgct ttagttgctc ttaagaaact ctggactgtg
     3901 tgtaaagtgt taagtgttga agaatttgat gccctgactc ctgtgattga atccagcctc
     3961 catcaagtgg aaagcatgca cggagcaggg aatgccaaga agaattggca acgcattcag
     4021 gagcatttct tttttgcaac atttcaccca ctcaaggatt attgtctaga gaccatattt
     4081 tacatccttc cacgcctttc aggccttatt gaagatgaat ggatcaccat tgataaattt
     4141 accagattca ctgatgttcc tttagctgcg ggatttcagt ggtacctttc tcaaactcaa
     4201 cttagtaaac taaaaccagg tgactggtct cagcaagaca taggtactaa tttggttgaa
     4261 gcagataacc aagcagagtg gaccgacgtt cagaagaaga ttatcccgtg gaacagtcgt
     4321 gtttccgact tagacctgga gctcctgttt caggatcgtg ctgccagact tggaaagtca
     4381 attagtagac tcatcgttgt ggcctcgctc atcgacaaac cgaccaattt aggaggactg
     4441 tgcaggacct gtgaggtatt tggggcttca gtgctcgttg ttggcagcct tcagtgtatc
     4501 agcgacaaac agtttcagca cctcagtgtc tctgcagaac agtggcttcc tctagtggag
     4561 gtaaaaccac ctcagctaat tgattatctg cagcagaaga aaacagaagg ttataccatc
     4621 attggagtgg aacaaactgc caaaagttta gacctaaccc aatattgctt tcctgagaaa
     4681 tctctgctct tgttgggaaa tgaacgtgag ggaattccag caaatctgat ccaacagttg
     4741 gacgtttgtg tggaaattcc tcaacagggc attatccgct ccctgaatgt ccatgtgagt
     4801 ggagccctgc tgatctggga gtacaccagg cagcagctgc tctcgcacgg agataccaag
     4861 ccatgatgtg ccttccttag tgaactgctg ctgctgttca gactttttta aaaaaaacta
     4921 tttggactaa agaaacagat tctgaaattt attgtgataa tttgtatttc ttttttcttg
     4981 caatttaatg ccaaaagttt gccatgtgcc ttaaacatat tactatatat tttccccttt
     5041 aataaacact ttttgttaaa ttgtattctt cctttaataa aatattttaa gcaattgtgg
     5101 aaataaaaca atggattttt taagagagaa
//

LOCUS       NM_005720               1520 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa
            (ARPC1B), mRNA.
ACCESSION   NM_005720
VERSION     NM_005720.2  GI:22907055
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Kaneda,A., Kaminishi,M., Nakanishi,Y., Sugimura,T. and Ushijima,T.
  TITLE     Reduced expression of the insulin-induced protein 1 and p41 Arp2/3
            complex genes in human gastric cancers
  JOURNAL   Int. J. Cancer 100 (1), 57-62 (2002)
   PUBMED   12115587
  REMARK    GeneRIF: INSIG1 and p41 Arp2/3 complex (p41-Arc)reduced expression
            might be involved in gastric cancer development or progression
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Machesky,L.M., Reeves,E., Wientjes,F., Mattheyse,F.J., Grogan,A.,
            Totty,N.F., Burlingame,A.L., Hsuan,J.J. and Segal,A.W.
  TITLE     Mammalian actin-related protein 2/3 complex localizes to regions of
            lamellipodial protrusion and is composed of evolutionarily
            conserved proteins
  JOURNAL   Biochem. J. 328 (Pt 1), 105-112 (1997)
   PUBMED   9359840
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J. Cell Biol. 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF006084.1 and BC002988.1.
            On Sep 16, 2002 this sequence version replaced gi:5031600.
            
            Summary: This gene encodes one of seven subunits of the human
            Arp2/3 protein complex. This subunit is a member of the SOP2 family
            of proteins and is most similar to the protein encoded by gene
            ARPC1A. The similarity between these two proteins suggests that
            they both may function as p41 subunit of the human Arp2/3 complex
            that has been implicated in the control of actin polymerization in
            cells. It is possible that the p41 subunit is involved in
            assembling and maintaining the structure of the Arp2/3 complex.
            Multiple versions of the p41 subunit may adapt the functions of the
            complex to different cell types or developmental stages.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1520
                     /gene="ARPC1B"
                     /note="synonyms: ARC41, p40-ARC, p41-ARC"
                     /db_xref="GeneID:10095"
                     /db_xref="MIM:604223"
     CDS             90..1208
                     /gene="ARPC1B"
                     /note="ARP2/3 protein complex subunit p41; actin related
                     protein 2/3 complex, subunit 1A (41 kD); actin related
                     protein 2/3 complex, subunit 1B (41 kD);
                     go_component: Arp2/3 protein complex [goid 0005885]
                     [evidence TAS] [pmid 9230079];
                     go_function: structural constituent of cytoskeleton [goid
                     0005200] [evidence TAS] [pmid 9230079];
                     go_process: cell motility [goid 0006928] [evidence TAS]
                     [pmid 9230079]"
                     /codon_start=1
                     /product="actin related protein 2/3 complex subunit 1B"
                     /protein_id="NP_005711.1"
                     /db_xref="GI:5031601"
                     /db_xref="GeneID:10095"
                     /db_xref="MIM:604223"
                     /translation="MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTK
                     VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV
                     RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAG
                     SCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVA
                     WVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAA
                     GMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISV
                     LSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK"
     polyA_signal    1481..1486
                     /gene="ARPC1B"
     polyA_site      1520
                     /gene="ARPC1B"
                     /evidence=experimental
ORIGIN      
        1 ggctgctgct ccggcgcgga gcccagagcc ggttcggcgc gtcgactgcc cagagtccgc
       61 ggccggggcg cgggaggagc caagccgcca tggcctacca cagcttcctg gtggagccca
      121 tcagctgcca cgcctggaac aaggaccgca cccagattgc catctgcccc aacaaccatg
      181 aggtgcatat ctatgaaaag agcggtgcca aatggaccaa ggtgcacgag ctcaaggagc
      241 acaacgggca ggtgacaggc atcgactggg cccccgagag taaccgtatt gtgacctgcg
      301 gcacagaccg caacgcctac gtgtggacgc tgaagggccg cacatggaag cccacgctgg
      361 tcatcctgcg gatcaaccgg gctgcccgct gcgtgcgctg ggcccccaac gagaacaagt
      421 ttgctgtggg cagcggctct cgtgtgatct ccatctgtta tttcgagcag gagaatgact
      481 ggtgggtttg caagcacatc aagaagccca tccgctccac cgtcctcagc ctggactggc
      541 accccaacaa tgtgctgctg gctgccggct cctgtgactt caagtgtcgg atcttttcag
      601 cctacatcaa ggaggtggag gaacggccgg cacccacccc gtggggctcc aagatgccct
      661 ttggggaact gatgttcgaa tccagcagta gctgcggctg ggtacatggc gtctgtttct
      721 cagccagcgg gagccgcgtg gcctgggtaa gccacgacag caccgtctgc ctggctgatg
      781 ccgacaagaa gatggccgtc gcgactctgg cctctgaaac actaccactg ctggcgctga
      841 ccttcatcac agacaacagc ctggtggcag cgggccacga ctgcttcccg gtgctgttca
      901 cctatgacgc cgccgcgggg atgctgagct tcggcgggcg gctggacgtt cctaagcaga
      961 gctcgcagcg tggcttgacg gcccgcgagc gcttccagaa cctggacaag aaggcgagct
     1021 ccgagggtgg cacggctgcg ggcgcgggcc tagactcgct gcacaagaac agcgtcagcc
     1081 agatctcggt gctcagcggc ggcaaggcca agtgctcgca gttctgcacc actggcatgg
     1141 atggcggcat gagtatctgg gatgtgaaga gcttggagtc agccttgaag gacctcaaga
     1201 tcaaatgacc tgtgaggaat atgttgcctt catcctagct gctggggaag cggggagagg
     1261 ggtcagggag gctaatggtt gctttgctga atgtttctgg ggtaccaata cgagttccca
     1321 taggggctgc tccctcaaaa agggagggga cagatgggga gcttttctta cctattcaag
     1381 gaatacgtgc ctttttctta aatgctttca tttattgaaa aaaaaaaaaa atgcccccaa
     1441 agcactatgc tggtcatgaa ctgcttcaaa atgtggaggt aataaaatgc aactgtgtaa
     1501 aaaaaaaaaa aaaaaaaaaa
//

LOCUS       NM_005730               4833 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II,
            polypeptide A) small phosphatase 2 (CTDSP2), mRNA.
ACCESSION   NM_005730
VERSION     NM_005730.2  GI:19923329
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4833)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J. Biol. Chem. 278 (28), 26078-26085 (2003)
   PUBMED   12721286
REFERENCE   2  (bases 1 to 4833)
  AUTHORS   Su,Y.A., Lee,M.M., Hutter,C.M. and Meltzer,P.S.
  TITLE     Characterization of a highly conserved gene (OS4) amplified with
            CDK4 in human sarcomas
  JOURNAL   Oncogene 15 (11), 1289-1294 (1997)
   PUBMED   9315096
REFERENCE   3  (bases 1 to 4833)
  AUTHORS   Su,Y.A., Lee,M.M., Hutter,C.M. and Meltzer,P.S.
  TITLE     Characterization of a highly conserved gene (OS4) co-amplified with
            CDK4 in human sarcomas
  JOURNAL   Oncogene 15, 1290-1294 (1997)
REFERENCE   4  (bases 1 to 4833)
  AUTHORS   Beutler,E., Gelbart,T., West,C., Kuhl,W. and Lee,P.
  TITLE     A strategy for cloning the hereditary hemochromatosis gene
  JOURNAL   Blood Cells Mol. Dis. 21 (3), 207-216 (1995)
   PUBMED   8673473
REFERENCE   5  (bases 1 to 4833)
  AUTHORS   Su,Y.A., Trent,J.M., Guan,X.Y. and Meltzer,P.S.
  TITLE     Direct isolation of genes encoded within a homogeneously staining
            region by chromosome microdissection
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (19), 9121-9125 (1994)
   PUBMED   8090779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF000152.1.
            On Apr 4, 2002 this sequence version replaced gi:5031964.
FEATURES             Location/Qualifiers
     source          1..4833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13-q15"
     gene            1..4833
                     /gene="CTDSP2"
                     /note="synonyms: OS4, SCP2"
                     /db_xref="GeneID:10106"
                     /db_xref="MIM:608711"
     CDS             306..1157
                     /gene="CTDSP2"
                     /note="conserved gene amplified in osteosarcoma;
                     NLI-interacting factor 2; small CTD phosphatase 2;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_component: soluble fraction [goid 0005625] [evidence
                     TAS] [pmid 9315096];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: phosphoprotein phosphatase activity [goid
                     0004721] [evidence IEA];
                     go_process: biological_process unknown [goid 0000004]
                     [evidence ND]"
                     /codon_start=1
                     /product="nuclear LIM interactor-interacting factor 2"
                     /protein_id="NP_005721.2"
                     /db_xref="GI:19923330"
                     /db_xref="GeneID:10106"
                     /db_xref="MIM:608711"
                     /translation="MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCC
                     FRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRI
                     CVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECV
                     LFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDN
                     SPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGAAAGPLACPA
                     SKRRPSQ"
ORIGIN      
        1 gccatttcct cctcttgttt tcactccgga ttctccatgt tggacccaaa ctgaggagcc
       61 cggagctgcc gctgggggat cggggccggg ggcacccggg ggagccgctg cccgggccgc
      121 ccgccctttg tacaggccgc ctcccttccc ggtccgggga ggaaacgaga ggggggatgt
      181 gaacagctgt ggaagtcgga gtctcgggag ccggagcggg cccccgccca ggccccccag
      241 cccagcccag cccgcgcgcc cgcccgtcct cccgtccagc cagcccgggc ccgcgggatt
      301 gttagatgga acacggctcc atcatcaccc aggcgcggag ggaagacgcc ctggtgctca
      361 ccaagcaagg cctggtctcc aagtcctctc ctaagaagcc tcgtggacgt aacatcttca
      421 aggccctttt ctgctgtttt cgcgcccagc atgttggcca gtcaagttcc tccactgagc
      481 tcgctgcgta taaggaggaa gcaaacacca ttgctaagtc ggatctgctc cagtgtctcc
      541 agtaccagtt ctaccagatc ccagggacct gcctgctccc agaggtgaca gaggaagatc
      601 aaggaaggat ctgtgtggtc attgacctcg atgaaaccct tgtgcatagc tcctttaagc
      661 caatcaacaa tgctgacttc atagtgccta tagagattga ggggaccact caccaggtgt
      721 atgtgctcaa gaggccttat gtggatgagt tcctgagacg catgggggaa ctctttgaat
      781 gtgttctctt cactgccagc ctggccaagt atgccgaccc tgtgacagac ctgctggacc
      841 ggtgtggggt gttccgggcc cgcctattcc gtgagtcttg cgtgttccac cagggctgct
      901 acgtcaagga cctcagccgc ctggggaggg acctgagaaa gaccctcatc ctggacaact
      961 cgcctgcttc ttacatattc caccccgaga atgcagtgcc tgtgcagtcc tggtttgatg
     1021 acatggcaga cactgagttg ctgaacctga tcccaatctt tgaggagctg agcggagcag
     1081 aggacgtcta caccagcctt ggggcagctg cgggcccctt agcctgccct gcttccaagc
     1141 gacggccatc ccagtagggg actttcccac actgtgcctt tacgatcagc gtgacagagt
     1201 agaagctgga gtgcctcacc acacggcccg gaaacagcgg gaagtaactg gaaagagctt
     1261 taggacagct tagatgccga gtgggcgaat gccagaccaa tgatacccag agctacctgc
     1321 cgccaacttg ttgagatgtg tgtttgactg tgagagagtg tgtgtttgtg tgtgtgtttt
     1381 gccatgaact gtggccccag tgtatagtgt ttcagtgggg gagaagctga aagaccaaga
     1441 ctcttcccaa gttagcttgt ctcctctcct gtcaccctaa gagccactga gttgtgtagg
     1501 gatgaaract attgaagact ccattgccaa accatggcct ttcctcagtg ttgtaaggcc
     1561 tatgccaagg ataaaggaag ggtatgcctt tgggtactcc aggcatacac ctttctgaaa
     1621 tccttctcca gccagctgct gcagacaaaa gatcacattt ctgggaagat gagaacttgt
     1681 ttccagacca gcatccagtg gccatcaggt cttgtggccc aaaggctatg cttgcctccg
     1741 gctgagtgcc tgggataggc cttttctatg tctccccaag gctggggtgc tgagcctgcc
     1801 ttcctcacca cctagccata gtctcaaacc tgtggggaag gaggttttct ccctgcccgg
     1861 gaagaggaca gataactgat ttccgttctt ttgactgtgt tttaaaattc tctttctaaa
     1921 cacagagtgt tgggcctggt ttgtttctga caaagttaca gtcctgggcc tgtaatgaat
     1981 gtcggcggcg ctggggttgc agggaaaaga caaatcctca aagcgtggac gtgtgtcccc
     2041 atggcttgtg gatcagctaa gctcgggatc atttccataa gtctgctttt cagggattct
     2101 ctgctggtgc tggtgcaagg acttctgttc caaaggctgg gaaaaactaa gctgtcccag
     2161 cccctcccat ttcttgggca gggctctttt cctgttgtgt cttcccccag ggcctgtcct
     2221 gtaccgagct ctgtctgttc cagcctacat ccttcctggg tgttgctttt cctcttaagg
     2281 gcctcagaac tcttgctctt cctggggtga gggggaatga gtgttcttga catgtgacag
     2341 cctaatgcgc atgctttctg cctctggtaa caggagtgag tgagcccctc agacctgcac
     2401 tctgggtgtc tcctgcttac aaaggttctt aatagtgaat gctttaaaat taaagtcatc
     2461 acgaaatgga agttttccca gggtggaaaa taagaggaag tgctgctgta attgggagca
     2521 caaggggcct cccaaaaagg agccccacct cagcatcact gccttaatcg tggcctccct
     2581 ggggtgggtg gggttctctc ctccctccct ccctcctcct ggggtgggag ggcgctcctg
     2641 ttcccatctc tgtgttccct ggaggcaggt atcacaaagc atttgtgaat tgctttaggt
     2701 gcagggacac cacccactca ggactcttcc ccatcatccc ttccattgcc acaccctaga
     2761 tccagcctca ggaactaaca agttktgaga aaagcaggtg gtagagcagc agcttcgtgc
     2821 tctcagcggt ggctggctgg catttttctc tagcgttgtg gtgccacctt cccttcttgt
     2881 cccaaggtta taaggccttg tctttctctt tggaatcata aagtggaaca gagtccccag
     2941 aactcatgtg ghcatttccg acagcatcac tccccggtgc ctatggggtc ccggtgtacc
     3001 taaagggaga aggaccccat gtgctagcca gaaatatact gtctcttgaa ggaaagcagg
     3061 agctcagact cttagagcca gctgtggctt cggacccaag gcctgaccta ggctgctatc
     3121 ctaatattgg aggaggggcc tctcttccaa gccccaccct aagggttagc ccttggacaa
     3181 atcttgtgcc gtctaggccc agccaggctt ttctgactaa ataagcaata agaggctcta
     3241 agctgactga gttgcaagga ccctttccgc cctcccttgg atctccatgt ttctccagat
     3301 ggcggaagag catgtgccac cccctttcct aacagacttg tccaagtgct tggcgtggga
     3361 cccatgacca aagcccagga tggcttggtg ggagtgtccc tgctgcatct gcatgaagcc
     3421 cctgcttttt aggcctcact cccatcagaa ccctgcctgc ccacctgcaa ctccccccca
     3481 acaatgccat tcccacttgc cccagagaag ctactcggcc aaacctagcc agggtctgtt
     3541 cttgtggacc agagccagcc tagtcattat ttgctgtcgg gtttccagtt tcaccgtgtg
     3601 ttagggtgag ggatgattgt aaaatttgct cctcaaagga atcaggccag actcaatttt
     3661 gggagggcaa gacagggagg aggccgcttc atcccagact ctcttctagg gcttcccacc
     3721 atcagcccct cccacttgag actggtcttt gggaggcaat aggccaccat gcctggtcag
     3781 caccaattca agccatgcca ggaatctgcc tacctgccag gttcagttct tttaaggtgc
     3841 ctcttcaggg acacagtgtg tctctctgat tgggcttcta aatcaaaagc ctgatgttcg
     3901 tgtccctctc atagggggag ctttggacac aggaccagtt tggaaaaggg tcaggtaagg
     3961 gtttccactc tgcacattgt agagggaaca ctctgtaggc ccatgggtcc cttactagag
     4021 aggttgagtg aatttgcctt cagttaacat gggaccttct gtttagcttc ctcttgcttc
     4081 ccaaagattt taagcatttt gtaaatgtat aaactcacct ctggtaacag tggcccagac
     4141 gctgctttgt gctaaaagca tgggaaatgt aaaggcagtc tttctctggg aaatggatgc
     4201 tattctattc tgctgcccct acctgttcct gaggcctcat ttagaaagaa aatcccctca
     4261 gaaggctgtc tggcacccag tgtcctagcc aggccaagta tatgagaaag gtaagtccat
     4321 tttccccttc aggtcctcag tggattactt aaccactgct gtccctcggt ccctttttcc
     4381 taaacgggtt tagttctgtc ttttttctcc ttttttctaa atgctggtaa atatttacat
     4441 tcagccaggg aagaggaggc cagaggtcgg gccagctgcc ccattctttt aacgttgtag
     4501 ggcctgccca tggagcggac cctcctcttt gggcctcgtg agcttttttg cttatcatgt
     4561 tccatttcgt gccgctttcc cccttcaaga tgccatttgg agggtagggg atctgcttcc
     4621 cactgtgact gggctatggg attctgacta ccttgcttac agattcatgg tttgataaat
     4681 ttgttgtatt ccaaaacttg aaatgcagga cgccattaag tgtctgttta tatttttgga
     4741 atatttgtat tacttacaat taattaataa aagtgggttt aaaaaacctt tccaggaaaa
     4801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_005754               2855 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens Ras-GTPase-activating protein SH3-domain-binding
            protein (G3BP), transcript variant 1, mRNA.
ACCESSION   NM_005754
VERSION     NM_005754.2  GI:38327550
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Kociok,N., Esser,P., Unfried,K., Parker,F., Schraermeyer,U.,
            Grisanti,S., Toque,B. and Heimann,K.
  TITLE     Upregulation of the RAS-GTPase activating protein (GAP)-binding
            protein (G3BP) in proliferating RPE cells
  JOURNAL   J. Cell. Biochem. 74 (2), 194-201 (1999)
   PUBMED   10404389
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Costa,M., Ochem,A., Staub,A. and Falaschi,A.
  TITLE     Human DNA helicase VIII: a DNA and RNA helicase corresponding to
            the G3BP protein, an element of the ras transduction pathway
  JOURNAL   Nucleic Acids Res. 27 (3), 817-821 (1999)
   PUBMED   9889278
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Parker,F., Maurier,F., Delumeau,I., Duchesne,M., Faucher,D.,
            Debussche,L., Dugue,A., Schweighoffer,F. and Tocque,B.
  TITLE     A Ras-GTPase-activating protein SH3-domain-binding protein
  JOURNAL   Mol. Cell. Biol. 16 (6), 2561-2569 (1996)
   PUBMED   8649363
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Onno,M., Nakamura,T., Hillova,J. and Hill,M.
  TITLE     Rearrangement of the human tre oncogene by homologous recombination
            between Alu repeats of nucleotide sequences from two different
            chromosomes
  JOURNAL   Oncogene 7 (12), 2519-2523 (1992)
   PUBMED   1461655
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647869.1, BG703413.1,
            BU517281.1, AK130003.1 and BX648012.1.
            On Nov 14, 2003 this sequence version replaced gi:5031702.
            
            Summary: This gene encodes one of the DNA-unwinding enzymes which
            prefers partially unwound 3'-tailed substrates and can also unwind
            partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.
            This enzyme is a member of the heterogeneous nuclear RNA-binding
            proteins and is also an element of the Ras signal transduction
            pathway. It binds specifically to the Ras-GTPase-activating protein
            by associating with its SH3 domain. Several alternatively spliced
            transcript variants of this gene have been described, but the
            full-length nature of some of these variants has not been
            determined.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1 and 2 encode the same isoform.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2855
                     /gene="G3BP"
                     /note="synonym: HDH-VIII"
                     /db_xref="GeneID:10146"
                     /db_xref="MIM:608431"
     CDS             172..1572
                     /gene="G3BP"
                     /note="GAP binding protein; RasGAP-associated
                     endoribonuclease G3BP;
                     go_component: cytoplasm [goid 0005737] [evidence NR];
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     9889278];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: RNA binding [goid 0003723] [evidence IEA];
                     go_function: helicase activity [goid 0004386] [evidence
                     IEA];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: protein binding [goid 0005515] [evidence TAS]
                     [pmid 8649363];
                     go_function: endonuclease activity [goid 0004519]
                     [evidence IEA];
                     go_function: protein transporter activity [goid 0008565]
                     [evidence IEA];
                     go_function: ATP-dependent DNA helicase activity [goid
                     0004003] [evidence TAS] [pmid 9889278];
                     go_function: ATP-dependent RNA helicase activity [goid
                     0004004] [evidence TAS] [pmid 9889278];
                     go_process: transport [goid 0006810] [evidence IEA];
                     go_process: protein-nucleus import [goid 0006606]
                     [evidence IEA];
                     go_process: Ras protein signal transduction [goid 0007265]
                     [evidence TAS] [pmid 8649363]"
                     /codon_start=1
                     /product="Ras-GTPase-activating protein SH3-domain-binding
                     protein"
                     /protein_id="NP_005745.1"
                     /db_xref="GI:5031703"
                     /db_xref="GeneID:10146"
                     /db_xref="MIM:608431"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGG
                     LDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNN
                     QALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQ
                     QTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPV
                     LEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVK
                     VPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMV
                     RHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQ
                     KVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGM
                     VQKPGFGVGRGLAPRQ"
     polyA_signal    2808..2813
                     /gene="G3BP"
     polyA_site      2835
                     /gene="G3BP"
ORIGIN      
        1 gagtggcagt tatatagacc ggcggcggag cacgcgtgtg tgcggacgca gttgcgtgag
       61 gggtttgtac tatcctcggt gctgtggtgc agagctagtt cctctccagc tcagccgcgt
      121 aggtttggac atatttgact cttttccccc caggttgaat tgaccaaagc aatggtgatg
      181 gagaagccta gtcccctgct ggtcgggcgg gaatttgtga gacagtatta cacactgctg
      241 aaccaggccc cagacatgct gcatagattt tatggaaaga actcttctta tgtccatggg
      301 ggattggatt caaatggaaa gccagcagat gcagtctacg gacagaaaga aatccacagg
      361 aaagtgatgt cacaaaactt caccaactgc cacaccaaga ttcgccatgt tgatgctcat
      421 gccacgctaa atgatggtgt ggtagtccag gtgatggggc ttctctctaa caacaaccag
      481 gctttgagga gattcatgca aacgtttgtc cttgctcctg aggggtctgt tgcaaataaa
      541 ttctatgttc acaatgatat cttcagatac caagatgagg tctttggtgg gtttgtcact
      601 gagcctcagg aggagtctga agaagaagta gaggaacctg aagaaagaca gcaaacacct
      661 gaggtggtac ctgatgattc tggaactttc tatgatcagg cagttgtcag taatgacatg
      721 gaagaacatt tagaggagcc tgttgctgaa ccagagcctg atcctgaacc agaaccagaa
      781 caagaacctg tatctgaaat ccaagaggaa aagcctgagc cagtattaga agaaactgcc
      841 cctgaggatg ctcagaagag ttcttctcca gcacctgcag acatagctca gacagtacag
      901 gaagacttga ggacattttc ttgggcatct gtgaccagta agaatcttcc acccagtgga
      961 gctgttccag ttactgggat accacctcat gttgttaaag taccagcttc acagccccgt
     1021 ccagagtcta agcctgaatc tcagattcca ccacaaagac ctcagcggga tcaaagagtg
     1081 cgagaacaac gaataaatat tcctccccaa aggggaccca gaccaatccg tgaggctggt
     1141 gagcaaggtg acattgaacc ccgaagaatg gtgagacacc ctgacagtca ccaactcttc
     1201 attggcaacc tgcctcatga agtggacaaa tcagagctta aagatttctt tcaaagttat
     1261 ggaaacgtgg tggagttgcg cattaacagt ggtgggaaat tacccaattt tggttttgtt
     1321 gtgtttgatg attctgagcc tgttcagaaa gtccttagca acaggcccat catgttcaga
     1381 ggtgaggtcc gtctgaatgt cgaagagaag aagactcgag ctgccaggga aggcgaccga
     1441 cgagataatc gccttcgggg acctggaggc cctcgaggtg ggctgggtgg tggaatgaga
     1501 ggccctcccc gtggaggcat ggtgcagaaa ccaggatttg gagtgggaag ggggcttgcg
     1561 ccacggcagt gaatcttcat ggatcttcat gcagccatac aaaccctggt tccaacagaa
     1621 tggtgaattt tcgacagcct ttggtatctt ggagtatgac cccagtctgt tataaactgc
     1681 ttaagtttgt ataattttac tttttttgtg tgttaatggt gtgtgctccc tctccctctc
     1741 ttccctttcc tgacctttag tctttcactt ccaattttgt ggaatgatat tttaggaata
     1801 acggactttt aaagaagcaa aaaaaaagac tgaatttcct tgcttacttt gcatatacag
     1861 actggatttt tttttttttt ttacagccat ttccccaaag gaatgtcttg catattactg
     1921 acatttggta tgtttcattc attggaatat ttcttatttt ctacgtgttt gaaaagcctg
     1981 taagaaatac aggatttgat aatattttga aggcaggaaa aacccaaatt gtttcttctt
     2041 tgagagtcat gactaccttc tggtgtggag aaattgccat tggaaaattt gacaattttg
     2101 attctcactg gtatgtttaa aaactgaata aaaggaatag aatttttttt tgataaagga
     2161 tcacaaaaca attctaaaac ctaactgttt ttaccattga aatttaaatt gtgataatag
     2221 gttttaaatg tctagaatgc aactgatagg cttttcttga actgttagtt tttttgaagt
     2281 agttttttca tgtttaattt gtatttgtaa aaaaacaaaa agcaaaaaaa ttcccaaaac
     2341 ccagataaca accagagcaa aactgttgtg ccttctattt atctttgatt tcagtcttgg
     2401 caattgttta aaaaaaaaat ctagatttgt tttattaggt tcagagtatg tggggaatta
     2461 tagaatccct ctttcatcac tttgtgtatg tcttttgtta acatatttgt tatgccttat
     2521 tctaaaattg agtctcaaac tggaatgcct ttgaagacag atgcttctat agaggttctt
     2581 tgacctaaat agttcagcat ttgtattttt attctggtat ctaatcagat tcctaatcat
     2641 agcccgtaag aaggaatgtt actttaatat tggactttgc tcatgtgctc gtgtccgcat
     2701 tttttttttt cttaaaatca tagccatatg gtaaattttc tattttgtta tggttctctt
     2761 ttattgatgg gcatgcagtg ggtgttactt ggaaatggcc aatttttatt aaaatatttc
     2821 tggaagaaaa tttaaaaaaa aaaaaaaaaa aaaaa
//

LOCUS       NM_005903               7012 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens SMAD, mothers against DPP homolog 5 (Drosophila)
            (SMAD5), transcript variant 1, mRNA.
ACCESSION   NM_005903
VERSION     NM_005903.5  GI:47778924
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7012)
  AUTHORS   Zimonjic,D.B., Durkin,M.E., Keck-Waggoner,C.L., Park,S.W.,
            Thorgeirsson,S.S. and Popescu,N.C.
  TITLE     SMAD5 gene expression, rearrangements, copy number, and
            amplification at fragile site FRA5C in human hepatocellular
            carcinoma
  JOURNAL   Neoplasia 5 (5), 390-396 (2003)
   PUBMED   14670176
  REMARK    GeneRIF: SMAD5 undergoes copy number gain and increased expression,
            rather than loss of expression, and therefore does not act as a
            tumor-suppressor gene in hepatocellular carcinoma
REFERENCE   2  (bases 1 to 7012)
  AUTHORS   Jullig,M. and Stott,N.S.
  TITLE     Mitochondrial localization of Smad5 in a human chondrogenic cell
            line
  JOURNAL   Biochem. Biophys. Res. Commun. 307 (1), 108-113 (2003)
   PUBMED   12849988
  REMARK    GeneRIF: Results demonstrate a mitochondrial distribution of Smad5
            in non-stimulated chondroprogenitor cells.
REFERENCE   3  (bases 1 to 7012)
  AUTHORS   Nagasako,T., Sugiyama,T., Mizushima,T., Miura,Y., Kato,M. and
            Asaka,M.
  TITLE     Up-regulated Smad5 mediates apoptosis of gastric epithelial cells
            induced by Helicobacter pylori infection
  JOURNAL   J. Biol. Chem. 278 (7), 4821-4825 (2003)
   PUBMED   12473652
  REMARK    GeneRIF: up-regulated Smad5 mediates apoptosis of gastric
            epithelial cells induced by Helicobacter pylori infection
REFERENCE   4  (bases 1 to 7012)
  AUTHORS   Zaidi,S.K., Sullivan,A.J., van Wijnen,A.J., Stein,J.L., Stein,G.S.
            and Lian,J.B.
  TITLE     Integration of Runx and Smad regulatory signals at
            transcriptionally active subnuclear sites
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (12), 8048-8053 (2002)
   PUBMED   12060751
  REMARK    GeneRIF: regulatory signals are active at transcriptionally
            subnuclear sites
REFERENCE   5  (bases 1 to 7012)
  AUTHORS   Fuchs,O., Simakova,O., Klener,P., Cmejlova,J., Zivny,J., Zavadil,J.
            and Stopka,T.
  TITLE     Inhibition of Smad5 in human hematopoietic progenitors blocks
            erythroid differentiation induced by BMP4
  JOURNAL   Blood Cells Mol. Dis. 28 (2), 221-233 (2002)
   PUBMED   12064918
  REMARK    GeneRIF: Smad5 activation by BMP4 in human hematopoietic cells
            results in significantly increased proliferation of erythroid
            progenitors and formation of glycophorin-A+ cells.
REFERENCE   6  (bases 1 to 7012)
  AUTHORS   Miyazono,K.
  TITLE     TGF-beta signaling by Smad proteins
  JOURNAL   Cytokine Growth Factor Rev. 11 (1-2), 15-22 (2000)
   PUBMED   10708949
REFERENCE   7  (bases 1 to 7012)
  AUTHORS   Wrana,J.L. and Attisano,L.
  TITLE     The Smad pathway
  JOURNAL   Cytokine Growth Factor Rev. 11 (1-2), 5-13 (2000)
   PUBMED   10708948
REFERENCE   8  (bases 1 to 7012)
  AUTHORS   Zavadil,J., Svoboda,P., Liang,H., Kottickal,L.V. and Nagarajan,L.
  TITLE     An antisense transcript to SMAD5 expressed in fetal and tumor
            tissues
  JOURNAL   Biochem. Biophys. Res. Commun. 255 (3), 668-672 (1999)
   PUBMED   10049768
REFERENCE   9  (bases 1 to 7012)
  AUTHORS   Gemma,A., Hagiwara,K., Vincent,F., Ke,Y., Hancock,A.R.,
            Nagashima,M., Bennett,W.P. and Harris,C.C.
  TITLE     hSmad5 gene, a human hSmad family member: its full length cDNA,
            genomic structure, promoter region and mutation analysis in human
            tumors
  JOURNAL   Oncogene 16 (7), 951-956 (1998)
   PUBMED   9484787
REFERENCE   10 (bases 1 to 7012)
  AUTHORS   Nishimura,R., Kato,Y., Chen,D., Harris,S.E., Mundy,G.R. and
            Yoneda,T.
  TITLE     Smad5 and DPC4 are key molecules in mediating BMP-2-induced
            osteoblastic differentiation of the pluripotent mesenchymal
            precursor cell line C2C12
  JOURNAL   J. Biol. Chem. 273 (4), 1872-1879 (1998)
   PUBMED   9442019
REFERENCE   11 (bases 1 to 7012)
  AUTHORS   Massague,J.
  TITLE     TGF-beta signal transduction
  JOURNAL   Annu. Rev. Biochem. 67, 753-791 (1998)
   PUBMED   9759503
REFERENCE   12 (bases 1 to 7012)
  AUTHORS   Hejlik,D.P., Kottickal,L.V., Liang,H., Fairman,J., Davis,T.,
            Janecki,T., Sexton,D., Perry,W. III, Tavtigian,S.V., Teng,D.H. and
            Nagarajan,L.
  TITLE     Localization of SMAD5 and its evaluation as a candidate myeloid
            tumor suppressor
  JOURNAL   Cancer Res. 57 (17), 3779-3783 (1997)
   PUBMED   9288787
REFERENCE   13 (bases 1 to 7012)
  AUTHORS   Zavadil,J., Brezinova,J., Svoboda,P., Zemanova,Z. and Michalova,K.
  TITLE     Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost
            and not mutated in the retained allele in human leukemia cell line
            HL60
  JOURNAL   Leukemia 11 (8), 1187-1192 (1997)
   PUBMED   9264367
REFERENCE   14 (bases 1 to 7012)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat. Genet. 13 (3), 347-349 (1996)
   PUBMED   8673135
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AF071108.1, BX648328.1,
            AF010601.1 and BK001394.1.
            On May 28, 2004 this sequence version replaced gi:38455399.
            
            Transcript Variant: This variant (1) encodes the same protein as
            variants 2 and 3.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..7012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31"
     gene            1..7012
                     /gene="SMAD5"
                     /note="synonyms: Dwfc, JV5-1, MADH5"
                     /db_xref="GeneID:4090"
                     /db_xref="MIM:603110"
     CDS             361..1758
                     /gene="SMAD5"
                     /note="mothers against decapentaplegic, drosophila,
                     homolog of, 5; MAD homolog 5; mothers against
                     decapentaplegic homolog 5; MAD, mothers against
                     decapentaplegic homolog 5; SMA- and MAD-related protein 5;
                     MAD, mothers against decapentaplegic homolog 5
                     (Drosophila);
                     go_component: nucleus [goid 0005634] [evidence NAS] [pmid
                     9759503];
                     go_component: integral to membrane [goid 0016021]
                     [evidence NAS] [pmid 10708949];
                     go_function: transcriptional activator activity [goid
                     0016563] [evidence NAS] [pmid 10708949];
                     go_function: receptor signaling protein activity [goid
                     0005057] [evidence NAS] [pmid 8673135];
                     go_process: signal transduction [goid 0007165] [evidence
                     NAS] [pmid 9759503];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA];
                     go_process: transforming growth factor beta receptor
                     signaling pathway [goid 0007179] [evidence NAS] [pmid
                     10708948]"
                     /codon_start=1
                     /product="SMAD, mothers against DPP homolog 5"
                     /protein_id="NP_005894.3"
                     /db_xref="GI:47778925"
                     /db_xref="GeneID:4090"
                     /db_xref="MIM:603110"
                     /translation="MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKK
                     KKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHH
                     ELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNL
                     SHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLP
                     ADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLL
                     AQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPLNPISSVS"
     polyA_signal    6994..6999
                     /gene="SMAD5"
     polyA_site      7010
                     /gene="SMAD5"
                     /note="alternate site"
     polyA_site      7011
                     /gene="SMAD5"
                     /evidence=experimental
ORIGIN      
        1 ccgggtcctg ggcgagcggg cgccgtgcgc gtgtcccgcg gccgagctgc taataaagtt
       61 gcagcgagga gaagcgcagc gacggcgtcg ggagagcgcg cctagccggc tcgcgaaaag
      121 gaagctgttg aagttattga agtacctgtt gctatattct aagaaattaa aatgtccaga
      181 aatctgcctc tgacttgacc caatgaaaga agcatatggc acttgtgaag ataaatgtta
      241 ctcctccctt tttaattgga acttctgctt aggacctgtg tatgacgttt cacctgtgat
      301 ctgttctttc ggtagccact gactttgagt tacaggaagg tctccgaaga tttgtgtcaa
      361 atgacgtcaa tggccagctt gttttctttt actagtccag cagtaaagcg attgttgggc
      421 tggaaacaag gtgatgagga ggagaaatgg gcagaaaagg cagttgatgc tttggtgaag
      481 aaactaaaaa agaaaaaggg tgccatggag gaactggaga aagccttgag cagtccagga
      541 cagccgagta aatgtgtcac tattcccaga tctttagatg gacgcctgca ggtttctcac
      601 agaaaaggct taccccatgt tatatattgt cgtgtttggc gctggccgga tttgcagagt
      661 catcatgagc taaagccgtt ggatatttgt gaatttcctt ttggatctaa gcaaaaagaa
      721 gtttgtatca acccatacca ctataagaga gtggagagtc cagtcttacc tccagtatta
      781 gtgcctcgtc ataatgaatt caatccacaa cacagccttc tggttcagtt taggaacctg
      841 agccacaatg aaccacacat gccacaaaat gccacgtttc cagattcttt ccaccagccc
      901 aacaacactc cttttccctt atctccaaac agcccttatc ccccttctcc tgctagcagc
      961 acatatccca actccccagc aagttctgga ccaggaagtc catttcagct cccagctgat
     1021 acgcctcctc ctgcctatat gccacctgat gatcagatgg gtcaagataa ttcccagcct
     1081 atggatacaa gcaataatat gattcctcag attatgccca gtatatccag cagggatgtt
     1141 cagcctgttg cctatgaaga gcctaaacat tggtgttcaa tagtctacta tgaattaaac
     1201 aatcgtgttg gagaagcttt tcatgcatct tctactagtg tgttagtaga tggattcaca
     1261 gatccttcaa ataacaaaag tagattctgc ttgggtttgt tgtcaaatgt taatcgtaat
     1321 tcgacaattg aaaacactag gcgacatatt ggaaaaggtg ttcatctgta ctatgttggt
     1381 ggagaggtgt atgcggaatg cctcagtgac agcagcatat ttgtacagag taggaactgc
     1441 aactttcatc atggctttca tcccaccact gtctgtaaga ttcccagcag ctgcagcctc
     1501 aaaattttta acaatcagga gtttgctcag cttctggctc aatctgtcaa ccatgggttt
     1561 gaggcagtat atgagctcac caaaatgtgt accattcgga tgagttttgt caagggttgg
     1621 ggagcagaat atcaccggca ggatgtaacc agcaccccat gttggattga gattcatctt
     1681 catgggcctc ttcagtggct ggataaagtc cttactcaga tgggctcccc tctgaacccc
     1741 atatcttctg tttcataatg cagaagtatt cttttcaatt atattgttag tggacttgtt
     1801 ttaattttag agaaactttg agtacagata ctgtgagctt acattgaaaa cagatattac
     1861 agcttatttt tttctacata attgtgacca atacatttgt attttgtgat gaatctacat
     1921 ttgtttgtat tcatgttcat gtgattaact cttagaagtg ttgtaaaaga tgcagagtaa
     1981 gtattatgcc ccagttcaga aatttggcat tgatcttaaa ctggaacatg cttttacttt
     2041 attgccctaa caatttttta ttaaatttat ttgaaaatgc atcacatgat gaaaaattat
     2101 agtagcttat aagagggcat atacagtgaa gagtaagttt tccctcctac tctcgatctt
     2161 ccagaagctg tacttttacc agtttctttg tcccaccaac ttaaaaaaaa aaagtacaat
     2221 tcattgtttt gcaaaagtgt atggtagggg cttaaaagaa actataaagt tttatttgaa
     2281 tgaacactat gcactgctgt aactggtagt gttcagtaaa agcaaaatga tagttttcta
     2341 gatgacataa aatttacatt taatacagat aagtgttctt cagtgtaatg tgacttcatg
     2401 ctatatatct tttgtaagac atttcctttt ttaaaaaaat ttttgcaaat aactgatctc
     2461 aagtatatgt catttactca aaatctgtca taagcattac tttatagcta gtgacagtgc
     2521 atgcacagcc ttgttcaact atgtttgctg cttttggaca atgttgcaag aactctattt
     2581 ttgacatgca ttaatctttt attttgcact tttatgggtg acagttttta gcataacctt
     2641 tgataaaata cactcaagtg acttggactt agatgcttat ccttacgtcc ttggtacctt
     2701 ttttgtatta acaaacactg caatttatag attacatttg taggaagtta tgcttttttc
     2761 tggtttttgt tttactttca acctaggtta taagactgtt attctatagc tccaacttaa
     2821 ggtgcctttt taattcccta cagttttatg ggtgttatca gtgctggaga atcatgtagt
     2881 taatcccatt gctcttacaa gtgtcagctt acttgtatca gcctccctac gcaaggacct
     2941 atgcactgga gccgtaggag gctcttcagt tgggccccaa ggataaggct actgatttga
     3001 tactaaatga atcagcagtg gatgtaggga tagctgattt taaaacactc ggctgggcac
     3061 agtggctcac acctgtaatc ccagcacttt gggaggctga ggcaggcaga tcatgatgtc
     3121 aggagtttga gaccagcctg gccaatatgg tgaaaccctg tctctacaaa aaatacaaaa
     3181 attagctggg catggtggtg cgtgcctgaa gtcccagcta ctcgggaagc tgaggcagaa
     3241 gaatcacttg aacctgggag gcggaggttg tggtgagccg agatcgcacc actgcactcc
     3301 agcctgggcg acagagcgag actctgcctc aaaaaacaaa acaaaacaaa acactcaccc
     3361 atcaacgaat atagactctt ctctcattta tcgatgatcc tctttttcca ttttttaagt
     3421 acttatgtgg aagctagtct cccaaaacac aatctttaga gagaaaagac atgaacgaac
     3481 tccaaaatat ccatttaatc aatcatgttt ttggctttgg ataaagaact ttgaaccagt
     3541 ttttttctca ggagctgtca aatggacact taattatgac atgagaatga agaaattatt
     3601 ttggaaaaaa aaaatgacct aatttaccta tcagtgaaag ctttattttc tggtgccttt
     3661 tgaaagtata tggagtcata tcattcttct gtttaaaatg ttagtttggt ttgactttcc
     3721 actttgtcct ttctgctctt gtgaagaaaa aaaaaagcat tttcgaggaa agaattatgc
     3781 aatttctttt gttttctgtg tcattattta ttgctttttc aatgtgcagc cagtggatgg
     3841 ttttagttct ttcagatgaa ctgccatttg tgtttcagct cacagttctt tgctgggtaa
     3901 aagaaatact ttctgacagt cacctgagcc ttaaatgtaa gtattacatg acatgcattc
     3961 tgtttcttcc agagttctgt ctgccacacg aaagagaata tttgcttact tgatagaact
     4021 ttggcatttt catcattctt ttacttaacc aggcttatgg catgatctct ggaacaaatt
     4081 tgtaggaaaa aattactcca attgaatgac tgatgtatgt aatcaacttc attgggctgc
     4141 agtaaactag tggaaattag agagttgttt tattggtgtt ttctactgtg agttaattaa
     4201 aaattgtttt tatttggggt cattatgtca cagtcttgag ttaacaagat cttacgtgat
     4261 tggccttttc tttgttttct cttaggagtt gtgtctcatg aatgacagta ctaaagctat
     4321 taacaactaa gagtttgaca gagaactata agcctgttgt atctcctaaa agttgtcaac
     4381 tccccaccct tggactttaa atgaaaattt tattcagtcc agctattctt acagtcccta
     4441 aggattttca tatatctatg tataggagat aaaatttgct agtaagattt ttaaaaactg
     4501 gctagtgaaa ggaaagtacc tctgaaagaa accattttag caaattatgg ttatatgttt
     4561 taatttaatc tacagaatgt tttatagtaa aattctagca ccactagaat aatcacatag
     4621 catgtacaat atatttatgc tggctgaaaa gacagaatct gggaataata aaattgcaac
     4681 cagtttggta atgcaaacag cagaatagaa tgaaatctca gtaatgaatt aaagcaacaa
     4741 aaagatattg attggcaaaa agcaagatat aagagattca tttgcttaac atttctacat
     4801 aatatttatg gtctggtcag tattggtctg gtcagtattg cctggctgac gtgaaatgta
     4861 aactagtagg cgtgttattg atctgctaaa actaaccctc tttttaagag gagatttaag
     4921 gaagacgtca atcaaaatgt caaatatgtg tgtcagaata taaataattt ttcacattgt
     4981 attgttgcta tataaaaaaa ataatagaat tggttgggtt tctgaggtga aatccagagt
     5041 aagagtacta gacagttcaa caagccacat ctaatggcac agatagagga tgtagctatt
     5101 ttataccttt cataacattt gagagtaaga tatccttcag gatgtgaagt gattattaag
     5161 tactcatacc tgaaatctgt tgtcaagatt agaactgggg ttcatgttaa aaaccttcca
     5221 tattacctga gggtacctgt ggggaacagt tccttcccct gtgtggtagt attttgttgg
     5281 aagagaatgt ttatacaaaa aatgaaattc ttccaacagc agagaaactc taaaaagttt
     5341 gatagtacct atcaaagtgc tgtacttctg tgatagagaa catctgatgt accaatttag
     5401 atctatttct ttatactttt tctaatcaat tgcttaatag tactttggat gattatcacc
     5461 tttgccactt aaaatatata aatatccttt ttacttcatg aggaaggaag aattttttga
     5521 taattactga gttcagcctt ttgtgatgac ttatattttg gacttacatt ttaactttaa
     5581 agaatgtcag atcccttctt tgtcttacta gttaaatcct cacctaatct cttgggtatg
     5641 aatataaatg tgtgtcatcg ttatattgtt cagctagatg agcaagtatc ttagggtagt
     5701 aggtagcctg gtggttttag aagtgtttgg tgatttttat ggagagagtt ttcctaagtg
     5761 gtggtttata ggtggtatca gatattatta gggcagcttt ttggggagta atctcaggtc
     5821 tcccagagca gcagcatttt tctcattgat ataagtaaga ttcttaggag cttttcttat
     5881 cacacaagat gcctgaatcg aatgtgagaa ttgaaggcat ttcttctgca taaacaaaga
     5941 attctacctg ctggacagaa acctggaaag ttctttggaa ttcgctgaat tacagtttag
     6001 tatgtcctga ttacagagtg acaatattta tcaagccttt gttatattgg attatcttct
     6061 ctcttaaaat acaactgtat tataattgaa atgacagccc aaaattggat ggtttaccaa
     6121 aaccaatgaa agggatttca cacatcaatt tttatttctg ttttgaagag cacatgctat
     6181 ataataattg ctagtagcaa ctgcagtaaa acaggtgata agttattttc tctgaaaaga
     6241 tccagtccta gagcaggatt cttcgatcat tcatggcaga gtgaaaaagg tttgtatggt
     6301 tcttgtccaa ataactcagt tcttaaaatt cttaaaatga tcgtaaacca ttatccttta
     6361 aaggtttatt tgaagatgct gttaaagtac agaattttgt gtacaggtag atttttccgt
     6421 ccctcattaa tagtgccttc ttaattaata cagactggtg ttagctataa caaaactcca
     6481 gtaaggccaa agaatcccaa gttctttgtg gaaaaaaaaa aaaaatcttt tagggtcaga
     6541 ttttcccttc taatatcatt gaagatgatg ttgcattgat ttattcataa agtattttaa
     6601 ctataggaac tctagaagat aatggttagg caagtgattt tttttttaaa tatggttggc
     6661 gtaagttgta ttttgaaatt cacttatttt aaaatcgaag aggattgtaa tcatggaaat
     6721 agaatgtttg tatctacctg cccacatttt cttaaaaaga tatttcatat acagataatg
     6781 aagaccaagc tagtggctgc actgtaggtc tgctgcttat ttgtatttgt tgtgcttctg
     6841 tttatgttgt agaagctgaa attctagcaa catgcttcaa ttctgttatt ttgatactta
     6901 tgaaaatgta ttaggtttta ctatattgtg cttttgaaag ccataactct taagaacttt
     6961 gtttttgcat attgtttgct aattctttac tttaataaac ctcaaaacct gc
//

LOCUS       NM_006016               3026 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens CD164 antigen, sialomucin (CD164), mRNA.
ACCESSION   NM_006016
VERSION     NM_006016.3  GI:34222157
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Ramsauer,V.P., Carraway,C.A., Salas,P.J. and Carraway,K.L.
  TITLE     Muc4/sialomucin complex, the intramembrane ErbB2 ligand,
            translocates ErbB2 to the apical surface in polarized epithelial
            cells
  JOURNAL   J. Biol. Chem. 278 (32), 30142-30147 (2003)
   PUBMED   12748185
  REMARK    GeneRIF: sialomucin has an important role in regulating ErbB2
            signaling
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Zannettino,A.C.
  TITLE     CD164.
  JOURNAL   J. Biol. Regul. Homeost. Agents 15 (4), 394-396 (2001)
   PUBMED   11862985
  REMARK    GeneRIF: Review article on structure and function of CD164.
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Chan,J.Y., Lee-Prudhoe,J.E., Jorgensen,B., Ihrke,G., Doyonnas,R.,
            Zannettino,A.C., Buckle,V.J., Ward,C.J., Simmons,P.J. and Watt,S.M.
  TITLE     Relationship between novel isoforms, functionally important
            domains, and subcellular distribution of CD164/endolyn
  JOURNAL   J. Biol. Chem. 276 (3), 2139-2152 (2001)
   PUBMED   11027692
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Doyonnas,R., Yi-Hsin Chan,J., Butler,L.H., Rappold,I.,
            Lee-Prudhoe,J.E., Zannettino,A.C., Simmons,P.J., Buhring,H.J.,
            Levesque,J.P. and Watt,S.M.
  TITLE     CD164 monoclonal antibodies that block hemopoietic progenitor cell
            adhesion and proliferation interact with the first mucin domain of
            the CD164 receptor
  JOURNAL   J. Immunol. 165 (2), 840-851 (2000)
   PUBMED   10878358
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Kurosawa,N., Kanemitsu,Y., Matsui,T., Shimada,K., Ishihama,H. and
            Muramatsu,T.
  TITLE     Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164
  JOURNAL   Eur. J. Biochem. 265 (1), 466-472 (1999)
   PUBMED   10491205
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Zannettino,A.C., Buhring,H.J., Niutta,S., Watt,S.M., Benton,M.A.
            and Simmons,P.J.
  TITLE     The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein
            expressed by human hematopoietic progenitors and bone marrow
            stromal cells that serves as a potent negative regulator of
            hematopoiesis
  JOURNAL   Blood 92 (8), 2613-2628 (1998)
   PUBMED   9763543
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Watt,S.M., Buhring,H.J., Rappold,I., Chan,J.Y., Lee-Prudhoe,J.,
            Jones,T., Zannettino,A.C., Simmons,P.J., Doyonnas,R., Sheer,D. and
            Butler,L.H.
  TITLE     CD164, a novel sialomucin on CD34(+) and erythroid subsets, is
            located on human chromosome 6q21
  JOURNAL   Blood 92 (3), 849-866 (1998)
   PUBMED   9680353
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Masuzawa,Y., Miyauchi,T., Hamanoue,M., Ando,S., Yoshida,J.,
            Takao,S., Shimazu,H., Adachi,M. and Muramatsu,T.
  TITLE     A novel core protein as well as polymorphic epithelial mucin carry
            peanut agglutinin binding sites in human gastric carcinoma cells:
            sequence analysis and examination of gene expression
  JOURNAL   J. Biochem. 112 (5), 609-615 (1992)
   PUBMED   1478919
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC011522.2.
            On Aug 26, 2003 this sequence version replaced gi:21361273.
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3026
                     /gene="CD164"
                     /note="synonyms: MGC-24, MUC-24, endolyn"
                     /db_xref="GeneID:8763"
                     /db_xref="MIM:603356"
     CDS             82..675
                     /gene="CD164"
                     /note="Sialomucin CD164;
                     go_component: endosome [goid 0005768] [evidence NAS] [pmid
                     11027692];
                     go_component: soluble fraction [goid 0005625] [evidence
                     NR];
                     go_component: membrane fraction [goid 0005624] [evidence
                     NR];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 9763543];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence NAS] [pmid 11027692];
                     go_process: development [goid 0007275] [evidence TAS]
                     [pmid 9680353];
                     go_process: hemopoiesis [goid 0030097] [evidence NAS]
                     [pmid 11027692];
                     go_process: cell adhesion [goid 0007155] [evidence TAS]
                     [pmid 9763543];
                     go_process: immune response [goid 0006955] [evidence TAS]
                     [pmid 9763543];
                     go_process: signal transduction [goid 0007165] [evidence
                     TAS] [pmid 9763543];
                     go_process: negative regulation of cell adhesion [goid
                     0007162] [evidence NAS] [pmid 10878358];
                     go_process: negative regulation of cell proliferation
                     [goid 0008285] [evidence TAS] [pmid 9763543];
                     go_process: negative regulation of cell proliferation
                     [goid 0008285] [evidence NAS] [pmid 10878358]"
                     /codon_start=1
                     /product="CD164 antigen, sialomucin"
                     /protein_id="NP_006007.2"
                     /db_xref="GI:21361274"
                     /db_xref="GeneID:8763"
                     /db_xref="MIM:603356"
                     /translation="MSRLSRSLLWAATCLGVLCVLSADKNTTQHPNVTTLAPISNVTS
                     APVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQV
                     GNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKST
                     FDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL"
ORIGIN      
        1 tcgacccacg cgtccggatt gaggggttga ctgagcgttg cgagccttag ctttctcccg
       61 aacgccagcg ctgaggacac gatgtcgcgg ctctcccgct cactgctttg ggccgccacc
      121 tgcctgggcg tgctctgcgt gctgtccgcg gacaagaaca cgacccagca cccgaacgtg
      181 acgactttag cgcccatctc caacgtaacc tcggcgccgg tgacgtccct cccgctggtc
      241 accactccgg caccagaaac ctgtgaaggt cgaaacagct gcgtttcctg ttttaatgtt
      301 agcgttgtta atactacctg cttttggata gaatgtaaag atgagagcta ttgttcacat
      361 aactcaacag ttagtgattg tcaagtgggg aacacgacag acttctgttc cgtttccacg
      421 gccactccag tgccaacagc caattctaca gctaaaccca cagttcagcc ctccccttct
      481 acaacttcca agacagttac tacatcaggt acaacaaata acactgtgac tccaacctca
      541 caacctgtgc gaaagtctac ctttgatgca gccagtttca ttggaggaat tgtcctggtc
      601 ttgggtgtgc aggctgtaat tttctttctt tataaattct gcaaatctaa agaacgaaat
      661 taccacactc tgtaaacaga cccattgaat taataaggac tggtgattca tttgtgtaac
      721 tcactgaagc caaaatacta tcttttaaga tgtcccacat ggaagacgct attccaggat
      781 ctttaaattt ccatggatgc atataggatg tttgggagca tcatccgtga agaaaaaatc
      841 aattaaatca ttgtgttcaa caggaatatt taaaatattc tgcatgaatc ctgtggctgt
      901 cttattttaa atagctgctg ctgtgggatt atattttttt tccttaacat gccaaatata
      961 actttctgaa agtgatggaa aatgttgtct tgtgcagaca acatcatggc tcttggcagt
     1021 ttaaatttag taattttaat ttagtgaaca gaattgagaa gaacgtgcca aatgagaatc
     1081 aattaggtgg atttttggct gtcatttcaa aagtggaata aatttattaa tttagtagta
     1141 ctaaatggta tccttagatt aaaattttgt gcttgataac agctgttttt tctacattag
     1201 aaataagatg ccacacaagg aactacattc cagatttaaa gaaatgaaag gataccatta
     1261 gtgtgtataa cagattattg ttcatacttg taaagcatct tatgtcattg agaatataaa
     1321 gaacagtgcc ttagaagaca gtgaaaggta agctctagct taatgtctat gatttgttct
     1381 ttgacattaa ggaaggtaag gattggtcag aggatgtaac ttgatgtgag cagtagtaaa
     1441 cctgttttag atatcatact gttaatattt tattgaaaat ttatttcaga gcggagaaac
     1501 ttaagctaaa gtctgttata cagaattgaa agccttcgta tcttgaacct cccaacattt
     1561 ttcttatggc tgttgaaaag tatagagcta aattgattta attacacttt cctttgtact
     1621 ttaaaaaaaa gtatgctagc actattgtac cttgaaagga tttccaccag actgtcttga
     1681 gtagtgactt ctttggtgag gcaagaagga tatacattat tttagaatca tttactattt
     1741 aaatgagaca atcatattat tttagaatca tttattttaa atgagacaat cattttaagt
     1801 tttaagataa cagaagtgac caatgtaatt tcacaacacc taaggatttt ttggttgatc
     1861 aggttactgt agatttttac tgattgtcct ggatgaatag actgtgcttt ttctttttct
     1921 ctcccttcct tcttggtttc ccatagtata ataagcatgc atactttaac ttctatagtt
     1981 ttctccttta gagggtcgtc ttcagtttta gaggtttact tctcccttgc ctttgactca
     2041 ttggactagt gcagaggctt taagtagttt aaaatgggct tttgcttttc taggtcatta
     2101 acgtttttta tttagtttct ttagccaata gtggctgagt ttcgcacttg attttcaata
     2161 ttttatagta agaaatgaca aactgctttg tttcatttca taaacaaact ctgcatttag
     2221 ataactatta aaggttgtta agatgaagat ttactgtttc tttgttactc gttggtacag
     2281 ctgtttgttt tacttgcaca tttgtacata tacttaatgt tttcaagtgc cttaattgtt
     2341 taaaatctct ggcttcaaag tttcttgggg aaaggtcggt ttacctcaca ttttttgttt
     2401 ccattagtaa tattctaggt acctcacaaa atgtattatg gtgccatggc tgttagtttt
     2461 tagtgagtgc tgtaggatta attcgaaaat aggcagaatt ccattcctcc caaggtggca
     2521 aaaattagct atactgatgt aattgtcatt tacctgggta tgaattccct gacacacatt
     2581 catgtcaaca tatgtagcaa attttgtgaa aacataacaa tttgaagctt ctgtaatttt
     2641 gagcactgct ctaacaacaa gcataatata aaattagtta gattttgcaa gtctacaaat
     2701 gagctcttgc aacagaactc acagcctttt tacttttttc ccctaacttt agcaatgtag
     2761 tatcttgagc cattaatttt tgggtttttt taaaatccag aaggtatata gaaacctttt
     2821 cagatttttc atctgatttg ttcttgcaga tgttcttcta tcaaatacct tattttacct
     2881 tacagatatt tgttgcacag gcagatactg ctgtatttag acatttctat ttcagttcat
     2941 taaaaactgc aaaaccaatc tgtatcatgt accaaactga cttaaaataa atctacatgt
     3001 ttattgaaaa aaaaaaaaaa aaaaaa
//

LOCUS       NM_006111               1584 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens acetyl-Coenzyme A acyltransferase 2 (mitochondrial
            3-oxoacyl-Coenzyme A thiolase) (ACAA2), nuclear gene encoding
            mitochondrial protein, mRNA.
ACCESSION   NM_006111
VERSION     NM_006111.1  GI:5174428
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Abe,H., Ohtake,A., Yamamoto,S., Satoh,Y., Takayanagi,M., Amaya,Y.,
            Takiguchi,M., Sakuraba,H., Suzuki,Y., Mori,M. et al.
  TITLE     Cloning and sequence analysis of a full length cDNA encoding human
            mitochondrial 3-oxoacyl-CoA thiolase
  JOURNAL   Biochim. Biophys. Acta 1216 (2), 304-306 (1993)
   PUBMED   8241273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D16294.1.
            
            Summary: The encoded protein catalyzes the last step of the
            mitochondrial fatty acid beta-oxidation spiral. Unlike most
            mitochondrial matrix proteins, it contains a non-cleavable
            amino-terminal targeting signal.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..1584
                     /gene="ACAA2"
                     /note="synonym: DSAEC"
                     /db_xref="GeneID:10449"
                     /db_xref="MIM:604770"
     CDS             49..1242
                     /gene="ACAA2"
                     /EC_number="2.3.1.16"
                     /note="mitochondrial 3-oxoacyl-CoA thiolase; beta
                     ketothiolase;
                     go_component: mitochondrion [goid 0005739] [evidence NR];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: acyltransferase activity [goid 0008415]
                     [evidence IEA];
                     go_function: acetyl-CoA C-acyltransferase activity [goid
                     0003988] [evidence IEA];
                     go_function: 3-oxoacyl-[acyl-carrier protein] reductase
                     activity [goid 0004316] [evidence NR];
                     go_process: fatty acid metabolism [goid 0006631] [evidence
                     IEA]"
                     /codon_start=1
                     /product="acetyl-coenzyme A acyltransferase 2"
                     /protein_id="NP_006102.1"
                     /db_xref="GI:5174429"
                     /db_xref="GeneID:10449"
                     /db_xref="MIM:604770"
                     /translation="MRLLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAG
                     KVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNG
                     CQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLP
                     MAMTAENLTVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQ
                     VDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPL
                     ARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSL
                     DLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVI
                     IQSTA"
     polyA_signal    1564..1569
                     /gene="ACAA2"
     polyA_site      1584
                     /gene="ACAA2"
ORIGIN      
        1 gcgtccccca caccacagac ccgcgccgcc gacgacccag cagccgccat gcgtctgctc
       61 cgaggtgtgt ttgtagttgc tgctaagcga acgccctttg gagcttacgg aggccttctg
      121 aaagacttca ctgctactga cttgtctgaa tttgctgcca aggctgcctt gtctgctggc
      181 aaagtctcac ctgaaacagt tgacagtgtg attatgggca atgtcctgca gagttcttca
      241 gatgctatat atttggcaag gcatgttggt ttgcgtgtgg gaatcccaaa ggagacccca
      301 gctctcacga ttaataggct ctgtggttct ggttttcagt ccattgtgaa tggatgtcag
      361 gaaatttgtg ttaaagaagc tgaagttgtt ttatgtggag gaaccgaaag catgagccaa
      421 gctccctact gtgtcagaaa tgtgcgtttt ggaaccaagc ttggatcaga tatcaagctg
      481 gaagattctt tatgggtatc attaacagat cagcatgtcc agctccccat ggcaatgact
      541 gcagagaatc ttactgtaaa acacaaaata agcagagaag aatgtgacaa atatgccctg
      601 cagtcacagc agagatggaa agctgctaat gatgctggct actttaatga tgaaatggca
      661 ccaattgaag tgaagacaaa gaaaggaaaa cagacaatgc aggtagacga gcatgctcgg
      721 ccccaaacca ccctggaaca gttacagaaa cttcctccag tattcaagaa agatggaact
      781 gttactgcag ggaatgcatc gggtgtagct gatggtgctg gagctgttat catagctagt
      841 gaagatgctg ttaagaaaca taacttcaca ccactggcaa gaattgtggg ctactttgta
      901 tctggatgtg atccctctat catgggtatt ggtcctgtcc ctgctatcag tggggcactg
      961 aagaaagcag gactgagtct taaggacatg gatttggtag aggtgaatga agcttttgct
     1021 ccccagtact tggctgttga gaggagtttg gatcttgaca taagtaaaac caatgtgaat
     1081 ggaggagcca ttgctttggg tcacccactg ggaggatctg gatcaagaat tactgcacac
     1141 ctggttcacg aattaaggcg tcgaggtgga aaatatgccg ttggatcagc ttgcattgga
     1201 ggtggccaag gtattgctgt catcattcag agcacagcct gaagagacca gtgagctcac
     1261 tgtgacccat ccttactcta cttggccagg ccacagtaaa acaagtgacc ttcagagcag
     1321 ctgccacaac tggccatgcc ctgccattga aacagtgatt aagtttgatc aagccatggt
     1381 gacacaaaaa tgcattgatc atgaatagga gcccatgcta gaagtacatt ctctcagatt
     1441 tgaaccagtg aaatatgatg tatttctgag ctaaaactca actatagaag acattaaaag
     1501 aaatcgtatt cttgccaagt aaccaccact tctgccttag ataatatgat tataaggaaa
     1561 tcaaataaat gttgccttaa cttc
//

LOCUS       NM_006117               1410 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens peroxisomal D3,D2-enoyl-CoA isomerase (PECI),
            transcript variant 1, mRNA.
ACCESSION   NM_006117
VERSION     NM_006117.2  GI:45643118
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Feng,X., Chuhjo,T., Sugimori,C., Kotani,T., Lu,X., Takami,A.,
            Takamatsu,H., Yamazaki,H. and Nakao,S.
  TITLE     Diazepam-binding inhibitor-related protein 1: a candidate
            autoantigen in acquired aplastic anemia patients harboring a minor
            population of paroxysmal nocturnal hemoglobinuria-type cells
  JOURNAL   Blood 104 (8), 2425-2431 (2004)
   PUBMED   15217832
  REMARK    GeneRIF: DRS-1 may serve as an autoantigen eliciting immune attack
            against hematopoietic stem cells in a subset of acquired aplastic
            anemia patients characterized by increased paroxysmal nocturnal
            hemoglobinuria-type cells
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J. Immunol. 169 (2), 1102-1109 (2002)
  MEDLINE   22092308
   PUBMED   12097419
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Janssen,U. and Stoffel,W.
  TITLE     Disruption of mitochondrial beta -oxidation of unsaturated fatty
            acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse
  JOURNAL   J. Biol. Chem. 277 (22), 19579-19584 (2002)
  MEDLINE   22028115
   PUBMED   11916962
  REMARK    GeneRIF: Disruption of mitochondrial beta -oxidation of unsaturated
            fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res. 11 (5), 677-684 (2001)
  MEDLINE   21235182
   PUBMED   11337467
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Geisbrecht,B.V., Zhang,D., Schulz,H. and Gould,S.J.
  TITLE     Characterization of PECI, a novel monofunctional Delta(3),
            Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes
  JOURNAL   J. Biol. Chem. 274 (31), 21797-21803 (1999)
  MEDLINE   99348312
   PUBMED   10419495
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Suk,K., Kim,Y.H., Hwang,D.Y., Ihm,S.H., Yoo,H.J. and Lee,M.S.
  TITLE     Molecular cloning and expression of a novel human cDNA related to
            the diazepam binding inhibitor
  JOURNAL   Biochim. Biophys. Acta 1454 (1), 126-131 (1999)
  MEDLINE   99284489
   PUBMED   10354522
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC033841.1, AU100345.1 and
            BQ653836.1.
            On Mar 23, 2004 this sequence version replaced gi:5174624.
            
            Summary: PECI is an auxiliary enzyme that catalyzes an
            isomerization step required for the beta-oxidation of unsaturated
            fatty acids.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.3"
     gene            1..1410
                     /gene="PECI"
                     /note="synonyms: DRS1, ACBD2, HCA88"
                     /db_xref="GeneID:10455"
                     /db_xref="MIM:608024"
     CDS             118..1212
                     /gene="PECI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-Coenzyme A binding domain containing 2; dJ1013A10.3;
                     go_component: peroxisome [goid 0005777] [evidence TAS]
                     [pmid 10419495];
                     go_function: acyl-CoA binding [goid 0000062] [evidence
                     IEA];
                     go_function: isomerase activity [goid 0016853] [evidence
                     IEA];
                     go_function: dodecenoyl-CoA delta-isomerase activity [goid
                     0004165] [evidence IEA];
                     go_process: metabolism [goid 0008152] [evidence IEA];
                     go_process: fatty acid metabolism [goid 0006631] [evidence
                     TAS] [pmid 10419495]"
                     /codon_start=1
                     /product="peroxisomal D3,D2-enoyl-CoA isomerase isoform 1"
                     /protein_id="NP_006108.2"
                     /db_xref="GI:45643119"
                     /db_xref="GeneID:10455"
                     /db_xref="MIM:608024"
                     /translation="MNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATE
                     GPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGT
                     DRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLT
                     GNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVG
                     ISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKL
                     TAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKLHAVN
                     AEECNVLQGRWLSDECTNAVVNFLSRKSKL"
ORIGIN      
        1 acccccgagc ccccgcagcc ctagagccgc ccaagggatg gcgatggcgt acttggcttg
       61 gagactggcg cggcgttcgt gtccgaggtc actagtttcc cggtagttca gctgcacatg
      121 aatagaacag caatgagagc cagtcagaag gactttgaaa attcaatgaa tcaagtgaaa
      181 ctcttgaaaa aggatccagg aaacgaagtg aagctaaaac tctacgcgct atataagcag
      241 gccactgaag gaccttgtaa catgcccaaa ccaggtgtat ttgacttgat caacaaggcc
      301 aaatgggacg catggaatgc ccttggcagc ctgcccaagg aagctgccag gcagaactat
      361 gtggatttgg tgtccagttt gagtccttca ttggaatcct ctagtcaggt ggagcctgga
      421 acagacagga aatcaactgg gtttgaaact ctggtggtga cctccgaaga tggcatcaca
      481 aagatcatgt tcaaccggcc caaaaagaaa aatgccataa acactgagat gtatcatgaa
      541 attatgcgtg cacttaaagc tgccagcaag gatgactcaa tcatcactgt tttaacagga
      601 aatggtgact attacagtag tgggaatgat ctgactaact tcactgatat tccccctggt
      661 ggagtagagg agaaagctaa aaataatgcc gttttactga gggaatttgt gggctgtttt
      721 atagattttc ctaagcctct gattgcagtg gtcaatggtc cagctgtggg catctccgtc
      781 accctccttg ggctattcga tgccgtgtat gcatctgaca gggcaacatt tcatacacca
      841 tttagtcacc taggccaaag tccggaagga tgctcctctt acacttttcc gaagataatg
      901 agcccagcca aggcaacaga gatgcttatt tttggaaaga agttaacagc gggagaggca
      961 tgtgctcaag gacttgttac tgaagttttc cctgatagca cttttcagaa agaagtctgg
     1021 accaggctga aggcatttgc aaagcttccc ccaaatgcct tgagaatttc aaaagaggta
     1081 atcaggaaaa gagagagaga aaaactacac gctgttaatg ctgaagaatg caatgtcctt
     1141 cagggaagat ggctatcaga tgaatgcaca aatgctgtgg tgaacttctt atccagaaaa
     1201 tcaaaactgt gatgaccact acagcagagt aaagcatgtc caaggaagga tgtgctgtta
     1261 cctctgattt ccagtactgg aactaaataa gcttcattgt gccttttgta gtgctagaat
     1321 atcaattaca atgatgatat ttcactacag ctctgatgaa taaaaagttt tgtaaaacaa
     1381 gcttaagaat tcaaaaaaaa aaaaaaaaaa
//

LOCUS       NM_006289               8187 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens talin 1 (TLN1), mRNA.
ACCESSION   NM_006289
VERSION     NM_006289.2  GI:16753232
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8187)
  AUTHORS   Tremuth,L., Kreis,S., Melchior,C., Hoebeke,J., Ronde,P.,
            Plancon,S., Takeda,K. and Kieffer,N.
  TITLE     A fluorescence cell biology approach to map the second
            integrin-binding site of talin to a 130-amino acid sequence within
            the rod domain
  JOURNAL   J. Biol. Chem. 279 (21), 22258-22266 (2004)
   PUBMED   15031296
  REMARK    GeneRIF: the integrin-binding site within the talin rod domain is
            important for beta(3)-cytoskeletal interactions but does not
            participate in alpha(IIb)beta(3) activation
REFERENCE   2  (bases 1 to 8187)
  AUTHORS   Giannone,G., Jiang,G., Sutton,D.H., Critchley,D.R. and Sheetz,M.P.
  TITLE     Talin1 is critical for force-dependent reinforcement of initial
            integrin-cytoskeleton bonds but not tyrosine kinase activation
  JOURNAL   J. Cell Biol. 163 (2), 409-419 (2003)
   PUBMED   14581461
  REMARK    GeneRIF: TLN1 is critical for force-dependent reinforcement of
            initial integrin-cytoskeleton bonds.
REFERENCE   3  (bases 1 to 8187)
  AUTHORS   Ling,K., Doughman,R.L., Firestone,A.J., Bunce,M.W. and
            Anderson,R.A.
  TITLE     Type I gamma phosphatidylinositol phosphate kinase targets and
            regulates focal adhesions
  JOURNAL   Nature 420 (6911), 89-93 (2002)
   PUBMED   12422220
  REMARK    GeneRIF: we show that the type I phosphatidylinositol phosphate
            kinase isoform-gamma 661 (PIPKI gamma 661), an enzyme that makes
            PtdIns(4,5)P(2), is targeted to focal adhesions by an association
            with talin
REFERENCE   4  (bases 1 to 8187)
  AUTHORS   Yan,B., Calderwood,D.A., Yaspan,B. and Ginsberg,M.H.
  TITLE     Calpain cleavage promotes talin binding to the beta 3 integrin
            cytoplasmic domain
  JOURNAL   J. Biol. Chem. 276 (30), 28164-28170 (2001)
   PUBMED   11382782
REFERENCE   5  (bases 1 to 8187)
  AUTHORS   Ben-Yosef,T. and Francomano,C.A.
  TITLE     Characterization of the human talin (TLN) gene: genomic structure,
            chromosomal localization, and expression pattern
  JOURNAL   Genomics 62 (2), 316-319 (1999)
   PUBMED   10610730
REFERENCE   6  (bases 1 to 8187)
  AUTHORS   Bass,M.D., Smith,B.J., Prigent,S.A. and Critchley,D.R.
  TITLE     Talin contains three similar vinculin-binding sites predicted to
            form an amphipathic helix
  JOURNAL   Biochem. J. 341 (Pt 2), 257-263 (1999)
   PUBMED   10393080
REFERENCE   7  (bases 1 to 8187)
  AUTHORS   Genini,M., Schwalbe,P., Scholl,F.A. and Schafer,B.W.
  TITLE     Isolation of genes differentially expressed in human primary
            myoblasts and embryonal rhabdomyosarcoma
  JOURNAL   Int. J. Cancer 66 (4), 571-577 (1996)
   PUBMED   8635876
REFERENCE   8  (bases 1 to 8187)
  AUTHORS   Gilmore,A.P., Ohanian,V., Spurr,N.K. and Critchley,D.R.
  TITLE     Localisation of the human gene encoding the cytoskeletal protein
            talin to chromosome 9p
  JOURNAL   Hum. Genet. 96 (2), 221-224 (1995)
   PUBMED   7635475
REFERENCE   9  (bases 1 to 8187)
  AUTHORS   Luna,E.J. and Hitt,A.L.
  TITLE     Cytoskeleton--plasma membrane interactions
  JOURNAL   Science 258 (5084), 955-964 (1992)
   PUBMED   1439807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF177198.1 and AF113217.1.
            On Nov 6, 2001 this sequence version replaced gi:5454129.
            
            Summary: This gene encodes a cytoskeletal protein which is
            concentrated in areas of cell-substratum and cell-cell contacts.
            This protein plays a significant role in the assembly of actin
            filaments and in spreading and migration of various cell types,
            including fibroblasts and osteoclasts. It codistributes with
            integrins in the cell surface membrane in order to assist in the
            attachment of adherent cells to extracellular matrices and of
            lymphocytes to other cells. The N-terminus of this protein contains
            elements for localization to cell-extracellular matrix junctions.
            The C-terminus contains binding sites for proteins such as
            beta-1-integrin, actin, and vinculin.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..8187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13"
     gene            1..8187
                     /gene="TLN1"
                     /note="synonyms: TLN, KIAA1027"
                     /db_xref="GeneID:7094"
                     /db_xref="MIM:186745"
     CDS             91..7716
                     /gene="TLN1"
                     /note="go_component: cytoskeleton [goid 0005856] [evidence
                     IEA];
                     go_component: focal adhesion [goid 0005925] [evidence NAS]
                     [pmid 10610730];
                     go_function: actin binding [goid 0003779] [evidence IEA];
                     go_function: structural constituent of cytoskeleton [goid
                     0005200] [evidence NAS] [pmid 10610730];
                     go_process: cell motility [goid 0006928] [evidence NAS]
                     [pmid 10610730];
                     go_process: cytoskeletal anchoring [goid 0007016]
                     [evidence NAS] [pmid 10610730]"
                     /codon_start=1
                     /product="talin 1"
                     /protein_id="NP_006280.2"
                     /db_xref="GI:16753233"
                     /db_xref="GeneID:7094"
                     /db_xref="MIM:186745"
                     /translation="MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPP
                     SDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMV
                     DDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEK
                     LKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQ
                     ARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGE
                     RKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITK
                     ECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLI
                     AGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALP
                     AIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQA
                     AQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPA
                     ETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLR
                     SAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAAL
                     VLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAG
                     RLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRY
                     DQATDTILTVTENIFSSMGDAGEMVGQARILAQATSDLVNAIKADAEGESDLENSRKL
                     LSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLV
                     QRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRG
                     SQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTA
                     LAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCT
                     QDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPA
                     VQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLP
                     GQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRG
                     TPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
                     ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLE
                     NPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGF
                     TEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSA
                     ATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTE
                     ENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESA
                     GGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAAL
                     NSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQ
                     LGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGG
                     NPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGP
                     MGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEA
                     KPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVS
                     EKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHR
                     EGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDP
                     ETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTV
                     KAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAV
                     AAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYL
                     ELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAE
                     NELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAAS
                     AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQE
                     KLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAF
                     EEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELR
                     DEH"
     polyA_signal    8148..8153
                     /gene="TLN1"
     polyA_site      8168
                     /gene="TLN1"
                     /evidence=experimental
ORIGIN      
        1 cccgagaagc ggcggggcgg cgggccggcg ggcggggcgc agagccaggc agcgcaggta
       61 tagccaggct ggagaaaaga agctgccacc atggttgcac tttcactgaa gatcagcatt
      121 gggaatgtgg tgaagacgat gcagtttgag ccgtctacca tggtgtacga cgcctgccgc
      181 atcattcgtg agcggatccc agaggcccca gctggtcctc ccagcgactt tgggctcttt
      241 ctgtcagatg atgaccccaa aaagggtata tggctggagg ctgggaaagc tttggactac
      301 tacatgctcc gaaatgggga cactatggag tacaggaaga aacagagacc cctgaagatc
      361 cgtatgctgg atggaactgt gaagacgatc atggtggatg actctaagac tgtcactgac
      421 atgctcatga ccatctgtgc ccgcattggc atcaccaatc atgatgaata ttcattggtt
      481 cgagagctga tggaagagaa aaaggaggaa ataacaggga ccttaagaaa ggacaagaca
      541 ttgctgcgag atgaaaagaa gatggagaaa ctaaagcaga aattgcacac agatgatgag
      601 ttgaactggc tggaccatgg tcggacactg agggagcagg gtgtagagga gcacgagacg
      661 ctgctgctgc ggaggaagtt cttttactca gaccagaatg tggattcccg ggaccctgta
      721 cagctgaacc tcctgtatgt gcaggcacga gatgacatcc tgaatggctc ccaccctgtc
      781 tcctttgaca aggcctgtga gtttgctggc ttccaatgcc agatccagtt tgggccccac
      841 aatgagcaga agcacaaggc tggcttcctt gacctgaagg acttcctgcc caaggagtat
      901 gtgaagcaga agggagagcg taagatcttc caggcacaca agaattgtgg gcagatgagt
      961 gagattgagg ccaaggtccg ctacgtgaag ctagcccgtt ctctcaagac ttacggtgtc
     1021 tccttcttcc tggtgaagga aaaaatgaaa gggaagaaca agctagtgcc caggcttctg
     1081 ggcatcacca aggagtgtgt gatgcgagtg gatgagaaga ccaaggaagt gatccaggag
     1141 tggaacctca ccaacatcaa acgctgggct gcgtctccca aaagcttcac cctggatttt
     1201 ggagattacc aagatggcta ttactcagta cagacaactg aaggggagca gattgcacag
     1261 ctcattgccg gctacatcga tatcatcctg aagaagaaaa aaagcaagga tcactttggg
     1321 ctggaaggag atgaggagtc tactatgctg gaggactcag tgtcccccaa aaagtcaaca
     1381 gtcctgcagc agcaatacaa ccgggtgggg aaagtggagc atggctctgt ggccctgcct
     1441 gccatcatgc gctctggagc ctctggtcct gagaatttcc aggtgggcag catgccccct
     1501 gcccagcagc agattaccag cggccagatg caccgaggac acatgcctcc tctgacttca
     1561 gcccagcagg cactcactgg aaccattaac tccagcatgc aggccgtgca ggctgcccag
     1621 gccaccctgg atgactttga cactctgccg cctcttggcc aggatgctgc ctctaaggcc
     1681 tggcgtaaaa acaagatgga tgaatcaaag catgagatcc actctcaggt agatgccatc
     1741 acagctggta ctgcgtctgt ggtgaacctg acagcagggg accctgctga gacagactat
     1801 accgcagtgg gctgtgcagt caccacaatc tcctccaacc tgacggagat gtcccgtggg
     1861 gtgaagctgc tggctgcctt gctggaggac gaaggcggca gtggtcggcc cctgttgcag
     1921 gcagcaaagg gccttgcggg agcagtgtca gaactgctgc gcagtgccca accagccagt
     1981 gctgagcccc gtcagaacct gctgcaagca gctgggaacg tgggccaggc cagtggggag
     2041 ctgttgcaac aaattgggga aagtgatact gacccccact tccaggatgc gctaatgcag
     2101 ctcgccaaag ctgtggcaag tgctgcagct gccctggtcc tcaaggccaa gagtgtggcc
     2161 cagcggacag aggactcggg acttcagacc caagttattg ctgcagcaac acagtgtgcc
     2221 ctatccactt cccaactagt ggcctgtact aaggtggtgg cacctacaat cagctcacct
     2281 gtctgccaag agcaactggt ggaggctgga cgactggtag ccaaagccgt ggagggctgt
     2341 gtgtctgcct cccaggcagc tacagaggat gggcaactgt tgcgaggggt aggagcagca
     2401 gccacagctg tcacccaggc cctaaatgag ctgctgcagc atgtgaaagc ccatgccaca
     2461 ggggctgggc ctgctggccg ttatgaccag gctactgaca ccatcctaac cgtcactgag
     2521 aacatcttta gctccatggg tgatgctggg gagatggtgg gacaggcccg catcctggcc
     2581 caagccacat ctgacctggt caatgccatc aaggctgatg ctgaggggga aagtgatctg
     2641 gagaactccc gcaagctctt aagtgctgcc aagatcctag ctgatgccac agccaagatg
     2701 gtagaggctg ccaagggagc agctgcccac cctgacagtg aggagcagca gcagcggctg
     2761 cgggaggcag ctgaggggct gcgcatggcc accaatgcag ctgcgcagaa tgccatcaag
     2821 aaaaagctgg tgcagcgcct ggagcatgca gccaagcagg ctgcagcctc agccacacag
     2881 accatcgctg cagctcagca cgcagcctct acccccaaag cctctgccgg cccccagccc
     2941 ctgctggtgc agagctgcaa ggcagtggca gagcagattc cactgctggt gcagggcgtc
     3001 cgaggaagcc aagcccagcc tgacagcccc agcgctcagc ttgccctcat tgctgccagc
     3061 cagagcttcc tgcagccagg tgggaagatg gtggcagctg caaaggcctc agtgccaacg
     3121 attcaggacc aggcttcagc catgcagctg agtcagtgtg ccaagaacct gggcaccgcg
     3181 ctggctgaac tccggacggc tgcccagaag gctcaggaag catgtggacc tttggagatg
     3241 gattctgcac tgagtgtggt acagaatcta gagaaagatc tacaggaagt gaaggcagca
     3301 gctcgagatg gcaagcttaa acccttacct ggggagacaa tggagaagtg tacccaggac
     3361 ctgggcaaca gcaccaaagc cgtgagctca gccatcgccc agctactggg agaggttgcc
     3421 cagggcaatg agaattatgc aggtattgca gctcgggatg tggcaggtgg gctgcggtca
     3481 ctggcccagg ccgctagggg agtcgctgca ctgacgtcag atcctgcagt gcaggccatt
     3541 gtacttgata cggccagtga tgtgctggac aaggccagca gcctcattga ggaggcgaaa
     3601 aaggcagctg gccatccagg ggaccctgag agccagcagc ggcttgccca ggtggctaaa
     3661 gcagtgaccc aggctctgaa ccgctgtgtc agctgcctac ctggccagcg cgatgtggat
     3721 aatgccctga gggcagttgg agatgccagc aagcgactcc tgagtgactc gcttcctcct
     3781 agcactggga catttcaaga agctcagagc cggttgaatg aagctgctgc tgggctgaat
     3841 caggcagcca cagaactggt gcaggcctct cggggaaccc ctcaggacct ggctcgagcc
     3901 tcaggccgat ttggacagga cttcagcacc ttcctggaag ctggtgtgga gatggcaggc
     3961 caggctccga gccaggagga ccgagcccaa gttgtgtcca acttgaaggg catctccatg
     4021 tcttcaagca aacttcttct ggctgccaag gccctgtcca cggaccctgc tgcccctaac
     4081 ctcaagagtc agctggctgc agctgccagg gcagtaactg acagcatcaa tcagctcatc
     4141 actatgtgca cccagcaggc acccggccag aaggagtgtg ataacgccct gcgggaattg
     4201 gagacggtcc gggaactcct ggagaaccca gtccagccca tcaatgacat gtcctacttt
     4261 ggttgcctgg acagtgtaat ggagaactca aaggtgctgg gcgaggccat gactggcatc
     4321 tcccaaaatg ccaagaacgg aaacctgcca gagtttggag atgccatttc cacagcctca
     4381 aaggcacttt gtggcttcac cgaggcagct gcacaggctg catatctggt tggtgtctct
     4441 gaccccaata gccaagctgg acagcaaggg ctagtggagc ccacacagtt tgcccgtgca
     4501 aaccaggcaa ttcagatggc ctgccagagt ttgggagagc ctggctgtac ccaggcccag
     4561 gtgctctctg cagccaccat tgtggctaaa cacacctctg cactgtgtaa cagctgtcgc
     4621 ctggcttctg cccgtaccac caatcctact gccaagcgcc agtttgtaca gtcagccaag
     4681 gaggtggcca acagcacagc taatcttgtc aagaccatca aggcgctaga tggggccttc
     4741 acagaggaga accgtgccca gtgccgagca gcaacagccc ctctgctgga ggctgtggac
     4801 aatctgagtg cctttgcgtc caaccctgag ttctccagca ttcctgccca gatcagccct
     4861 gagggtcggg ctgccatgga gcccattgtg atctctgcca agacaatgtt agagagtgcc
     4921 gggggactca tccagacagc ccgggccctc gcagtcaatc cccgggaccc cccgagctgg
     4981 tcggtgctgg ccggccactc ccgtactgtc tcagactcca tcaagaagct aattacaagc
     5041 atgagggaca aggctccagg gcagctggag tgtgaaacgg ccattgcagc tctgaacagt
     5101 tgtctacggg acctagacca ggcttccctc gctgcagtca gccagcagct tgctccccgt
     5161 gagggaatct ctcaagaggc cttgcacact cagatgctca ctgcagtcca agagatctcc
     5221 catctcattg agccgctggc caatgctgcc cgggctgaag cctcccagct gggacacaag
     5281 gtgtcccaga tggcgcagta ctttgagccg ctcaccctgg ctgcagtggg tgctgcctcc
     5341 aagaccctga gccacccgca gcagatggca ctcctggacc agactaaaac attggcagag
     5401 tctgccctgc agttgctata cactgccaag gaggctggtg gtaacccaaa gcaagcagct
     5461 cacacccagg aagccctgga ggaggctgtg cagatgatga ccgaggccgt agaggacctg
     5521 acaacaaccc tcaacgaggc agccagtgct gctggggtcg tgggtggcat ggtggactcc
     5581 atcacccagg ccatcaacca gctagatgaa ggaccaatgg gtgaaccaga aggttccttc
     5641 gtggattacc aaacaactat ggtgcggaca gccaaggcca ttgcagtgac cgttcaggag
     5701 atggttacca agtcaaacac cagcccagag gagctgggcc ctcttgctaa ccagctgacc
     5761 agtgactatg gccgtctggc ctcggaggcc aagcctgcag cggtggctgc tgaaaatgaa
     5821 gagataggtt cccatatcaa acaccgggta caggagctgg gccatggctg tgccgctctg
     5881 gtcaccaagg caggcgccct gcagtgcagc cccagtgatg cctacaccaa gaaggagctc
     5941 atagagtgtg cccggagagt ctctgagaag gtctcccacg tcctggctgc gctccaggct
     6001 gggaatcgtg gcacccaggc ctgcatcaca gcagccagcg ctgtgtctgg tatcattgct
     6061 gacctcgaca ccaccatcat gttcgccact gctggcacgc tcaatcgtga gggtactgaa
     6121 actttcgctg accaccggga gggcatcctg aagactgcga aggtgctggt ggaggacacc
     6181 aaggtcctgg tgcaaaacgc agctgggagc caggagaagt tggcgcaggc tgcccagtcc
     6241 tccgtggcga ccatcacccg cctcgctgat gtggtcaagc tgggtgcagc cagcctggga
     6301 gctgaggacc ctgagaccca ggtggtacta atcaacgcag tgaaagatgt agccaaagcc
     6361 ctgggagacc tcatcagtgc aacgaaggct gcagctggca aagttggaga tgaccctgct
     6421 gtgtggcagc taaagaactc tgccaaggtg atggtgacca atgtgacatc attgcttaag
     6481 acagtaaaag ccgtggaaga tgaggccacc aaaggcactc gggccctgga ggcaaccaca
     6541 gaacacatac ggcaggagct ggcggttttc tgttccccag agccacctgc caagacctct
     6601 accccagaag acttcatccg aatgaccaag ggtatcacca tggcaaccgc caaggccgtt
     6661 gctgctggca attcctgtcg ccaggaagat gtcattgcca cagccaatct gagccgccgt
     6721 gctattgcag atatgcttcg ggcttgcaag gaagcagctt accacccaga agtggcccct
     6781 gatgtgcggc ttcgagccct gcactatggc cgggagtgtg ccaatggcta cctggaactg
     6841 ctggaccatg tactgctgac cctgcagaag ccaagcccag aactgaagca gcagttgaca
     6901 ggacattcaa agcgtgtggc tggttccgtc actgagctca tccaggctgc tgaagccatg
     6961 aagggaacag aatgggtaga cccagaggac cccacagtca ttgctgagaa tgagctcctg
     7021 ggagctgcag ccgccattga ggctgcagcc aaaaagctag agcagctgaa gccccgggcc
     7081 aaacccaagg aggcagatga gtccttgaac tttgaggagc agatactaga agctgccaag
     7141 tccattgcag cagccaccag tgcactggta aaggctgcgt cggctgccca gagagaacta
     7201 gtggcccaag ggaaggtggg tgccattcca gccaatgcac tggacgatgg gcagtggtcc
     7261 cagggcctca tttctgctgc ccggatggtg gctgcggcca ccaacaatct gtgtgaggca
     7321 gccaatgcag ctgtacaagg ccatgccagc caggagaagc tcatctcatc agccaagcag
     7381 gtagctgcct ccacagccca gctccttgtg gcctgcaagg tcaaggctga ccaggactcg
     7441 gaggcaatga aacgacttca ggctgctggc aacgcagtga agcgagcctc agataatctg
     7501 gtgaaagcag cacagaaggc tgcagccttt gaagagcagg agaatgagac agtggtggtg
     7561 aaagagaaga tggttggcgg cattgcccag atcatcgcag cacaggaaga aatgcttcgg
     7621 aaggaacgag agctggaaga ggcgcggaag aaactggccc agatccggca gcagcagtac
     7681 aagtttctgc cttcagagct tcgagatgag cactaaagaa gcctcttcta tttaatgcag
     7741 acccggccca gagactgtgc gtgccactac caaagccttc tgggctgtcg gggcccaacc
     7801 tgcccaaccc cagcactccc caaagtgcct gccaaacccc agggcctggc cccgcccagt
     7861 cccgcagtac atcccctgtc ccctccccaa ccccaagtgc cttcatgccc tagggccccc
     7921 caagtgcctg cccctcccca gagtattaac gctccaagag tattattaac gctgctgtac
     7981 ctcgatctga atctgccggg gccccagccc actccaccct gccagcagct tccagccagt
     8041 ccccacagcc tcatcagctc tcttcaccgt tttttgatac tatcttcccc cacccccagc
     8101 tacccatagg ggctgcagag ttataagccc caaacaggtc atgctccaat aaaaatgatt
     8161 ctacctacaa aaaaaaaaaa aaaaaaa
//

LOCUS       NM_006320               1874 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens progesterone receptor membrane component 2 (PGRMC2),
            mRNA.
ACCESSION   NM_006320
VERSION     NM_006320.1  GI:5453915
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Gerdes,D., Wehling,M., Leube,B. and Falkenstein,E.
  TITLE     Cloning and tissue expression of two putative steroid membrane
            receptors
  JOURNAL   Biol. Chem. 379 (7), 907-911 (1998)
   PUBMED   9705155
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ002030.1.
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..1874
                     /gene="PGRMC2"
                     /note="synonyms: DG6, PMBP"
                     /db_xref="GeneID:10424"
                     /db_xref="MIM:607735"
     CDS             7..678
                     /gene="PGRMC2"
                     /note="go_component: microsome [goid 0005792] [evidence
                     IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence TAS] [pmid 9705155];
                     go_function: receptor activity [goid 0004872] [evidence
                     IEA];
                     go_function: steroid binding [goid 0005496] [evidence TAS]
                     [pmid 9705155];
                     go_function: steroid hormone receptor activity [goid
                     0003707] [evidence TAS] [pmid 9705155]"
                     /codon_start=1
                     /product="progesterone membrane binding protein"
                     /protein_id="NP_006311.1"
                     /db_xref="GI:5453916"
                     /db_xref="GeneID:10424"
                     /db_xref="MIM:607735"
                     /translation="MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAA
                     LALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRD
                     FSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCL
                     DKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKD
                     HNKQD"
ORIGIN      
        1 ccggtgatgg cggctggtga tggggacgtg aagctaggca ccctggggag tggcagcgag
       61 agcagcaacg acggcggcag cgagagtcca ggcgacgcgg gagcggcagc ggaaggggga
      121 ggctgggcgg cggcggcgtt ggcgcttctg acggggggcg gggaaatgct gctgaacgtg
      181 gcgctggtgg ctctggtgct gctgggggcc taccggctgt gggtgcgctg ggggcggcgg
      241 ggtctggggg ccggggccgg ggcgggcgag gagagccccg ccacctctct gcctcgcatg
      301 aagaagcggg acttcagctt ggagcagctg cgccagtacg acggctcccg caacccgcgc
      361 atcctgctcg cggtcaatgg gaaagtcttc gacgtgacca aaggcagcaa gttctacggc
      421 ccggcgggtc catatggaat atttgctggt agggatgcct ccagaggact ggccacattt
      481 tgcctagata aagatgcact tagagatgaa tatgatgatc tctcagattt gaatgcagta
      541 caaatggaga gtgttcgaga atgggaaatg cagtttaaag aaaaatatga ttatgtaggc
      601 agactcctaa aaccaggaga agaaccatca gaatatacag atgaagaaga taccaaggat
      661 cacaataaac aggattgaac tttgtaaaca accaaagtca ggggccttca gaactgcaat
      721 tcttactccc tttcacagac tgtccggagt ctttgggttt gattcacctg ctgcgaaaaa
      781 cattcaacaa attgtgtaca agataaatta atctcactat gaagatttga ataactagac
      841 attatttatg ctgccaaact catttgttgc agttgtttgt aatgtctagt ggggcttcat
      901 catcctgaaa agaaggagac agggattttt ttaaagagca agaaagtcac aatattactt
      961 ctttccttcc ttttttcctt ctttcctttc ttctttctct ttctttcttt ttaaaatata
     1021 ttgaagacaa ccagatatgt atttgctact caagtgtaca gatctcctca agaaacatca
     1081 agggactcct gtgtcacata ctgtgttttt attttaacat gggtgaggga ggcgacctga
     1141 tcaggggagg tgggggtaca catcaatttg agttgttcag gctactgaaa cattaaaatg
     1201 tgaattccca aacttttctt tttggctttg tcagggaaaa gaaaaatatc tttataaaga
     1261 aatctttgga aattaggaga aggaatttca ggtgggttta agtcagagct agttccccaa
     1321 cagaaagatc atttgaaacc agtttttatc ccttctcttt ccttcccttt ccctaaatca
     1381 aatcaatatt aattgtgcct tatttcactt aacatagact tgaattattt ttagggaaag
     1441 cccctataat gaattcagaa atcactacaa gcagcattaa gactgaagtt ggaatattct
     1501 gttgaccata aaaccttgat atcattctgt gtatatagaa tgtaaaagga atattacagt
     1561 gttaactgcc atatatgtaa tatacacaaa ctcaattagc attgtaatgg ccaaatgcat
     1621 tcccccatgc ttttctgttt tcaaaaaaat tgaaaaacaa atcaactctt atccccaaca
     1681 gctgcctaat tttaggagtc tgaccctcca catctcactg gtgtgggtgc atggggctgt
     1741 ggagtgggtg tcagtatgga tgtgtctgaa tgtgtgaggc cttggaaggg actctttctg
     1801 cagatactgt aaatacaagt accattttaa taaagcatgt acaataaacc aaaaaaaaaa
     1861 aaaaaaaaaa aaaa
//

LOCUS       NM_006341               1056 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2),
            mRNA.
ACCESSION   NM_006341
VERSION     NM_006341.2  GI:6006019
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Masuda,Y., Ohmae,M., Masuda,K. and Kamiya,K.
  TITLE     Structure and enzymatic properties of a stable complex of the human
            REV1 and REV7 proteins
  JOURNAL   J. Biol. Chem. 278 (14), 12356-12360 (2003)
   PUBMED   12529368
  REMARK    GeneRIF: purified human REV1 and REV7 proteins form a heterodimer
            in solution, which is stable through intensive purification steps.
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Murakumo,Y., Roth,T., Ishii,H., Rasio,D., Numata,S., Croce,C.M. and
            Fishel,R.
  TITLE     A human REV7 homolog that interacts with the polymerase zeta
            catalytic subunit hREV3 and the spindle assembly checkpoint protein
            hMAD2
  JOURNAL   J. Biol. Chem. 275 (6), 4391-4397 (2000)
   PUBMED   10660610
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Nelson,K.K., Schlondorff,J. and Blobel,C.P.
  TITLE     Evidence for an interaction of the metalloprotease-disintegrin
            tumour necrosis factor alpha convertase (TACE) with mitotic arrest
            deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9
            with a novel MAD2-related protein, MAD2beta
  JOURNAL   Biochem. J. 343 Pt 3, 673-680 (1999)
   PUBMED   10527948
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Cahill,D.P., da Costa,L.T., Carson-Walter,E.B., Kinzler,K.W.,
            Vogelstein,B. and Lengauer,C.
  TITLE     Characterization of MAD2B and other mitotic spindle checkpoint
            genes
  JOURNAL   Genomics 58 (2), 181-187 (1999)
   PUBMED   10366450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF139365.1.
            On Oct 1, 1999 this sequence version replaced gi:5453731.
            
            Summary:   MAD2L2 is a component of the mitotic spindle assembly
            checkpoint that prevents the onset of anaphase until all
            chromosomes are properly aligned at the metaphase plate.  MAD2L2 is
            a homolog of MAD2L1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36"
     gene            1..1056
                     /gene="MAD2L2"
                     /note="synonyms: REV7, MAD2B"
                     /db_xref="GeneID:10459"
                     /db_xref="MIM:604094"
     CDS             112..747
                     /gene="MAD2L2"
                     /note="mitotic arrest deficient homolog-like 2; MAD2
                     (mitotic arrest deficient, yeast, homolog)-like 2;
                     go_process: cell cycle [goid 0007049] [evidence IEA];
                     go_process: mitosis [goid 0007067] [evidence NAS] [pmid
                     10366450];
                     go_process: mitotic spindle checkpoint [goid 0007094]
                     [evidence TAS] [pmid 10366450]"
                     /codon_start=1
                     /product="MAD2 homolog"
                     /protein_id="NP_006332.2"
                     /db_xref="GI:6006020"
                     /db_xref="GeneID:10459"
                     /db_xref="MIM:604094"
                     /translation="MTTLTRQDLNFGQVVAAVLCEFLEVAVHLILYVREVYPVGIFQK
                     RKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEI
                     TQPPLLSISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNM
                     EKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKGS"
     polyA_signal    1015..1020
                     /gene="MAD2L2"
     polyA_site      1041
                     /gene="MAD2L2"
ORIGIN      
        1 cgcgaggccc gggttgagcg ggaggcgcga tcggtccggt cggtggctcc ccgcggcggg
       61 gccgggcccg atctcgggcg ggaaccgagc gcagagccgg tagcgggaag gatgaccacg
      121 ctcacacgac aagacctcaa ctttggccaa gtggtggccg ctgtgctctg cgagttcctg
      181 gaggtggctg tgcatctcat cctctacgtg cgcgaggtct accccgtggg catcttccag
      241 aaacgcaaga agtacaacgt gccggtccag atgtcctgcc acccggagct gaatcagtat
      301 atccaggaca cgctgcactg cgtcaagcca ctcctggaga agaatgatgt ggagaaagtg
      361 gtggtggtga ttttggataa agagcaccgc ccagtggaga aattcgtctt tgagatcacc
      421 cagcctccac tgctgtccat cagctcagac tcgctgttgt ctcatgtgga gcagctgctc
      481 cgggccttca tcctgaagat cagcgtgtgc gatgccgtcc tggaccacaa ccccccaggc
      541 tgtaccttca cagtcctggt gcacacgaga gaagccgcca ctcgcaacat ggagaagatc
      601 caggtcatca aggatttccc ctggatcctg gcggatgagc aggatgtcca catgcatgac
      661 ccccggctga taccactaaa aaccatgacg tcggacattt taaagatgca gctttacgtg
      721 gaagagcgcg ctcataaagg cagctgaggg ggcacctgcc accccactga tgcccaaact
      781 gtcagacttt gggggatccc cgcctagggc agtgctgcat ggctgccctg attccaagtg
      841 ctcttatcgc ctctgtgtgt ggatcgcccg ccccagcccg gggccgctca ggtctgcttg
      901 gaggatgcct cccccaggag ggcagtgagg gatgccgcaa cctcgacttc tcagcctcct
      961 ggggttccgc cggccaacac tgtctgtctc aaatactgtg ctgtgagttg tttcaataaa
     1021 ggggcccaag ggctgggctg aaaaaaaaaa aaaaaa
//

LOCUS       NM_006410               1438 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens HIV-1 Tat interactive protein 2, 30kDa (HTATIP2),
            mRNA.
ACCESSION   NM_006410
VERSION     NM_006410.3  GI:34147574
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Jiang,C., Ito,M., Piening,V., Bruck,K., Roeder,R.G. and Xiao,H.
  TITLE     TIP30 interacts with an estrogen receptor alpha-interacting
            coactivator CIA and regulates c-myc transcription
  JOURNAL   J. Biol. Chem. 279 (26), 27781-27789 (2004)
   PUBMED   15073177
  REMARK    GeneRIF: TIP30 interacts with an estrogen receptor
            alpha-interacting coactivator CIA and regulates ERalpha-mediated
            c-myc transcription.
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Baker,M.E., Yan,L. and Pear,M.R.
  TITLE     Three-dimensional model of human TIP30, a coactivator for HIV-1
            Tat-activated transcription, and CC3, a protein associated with
            metastasis suppression
  JOURNAL   Cell. Mol. Life Sci. 57 (5), 851-858 (2000)
   PUBMED   10892349
  REMARK    GeneRIF: TIP30/CC3 is a member of the short-chain
            dehydrogenases/reductases (SDR) family and is associated with
            metastasis suppression
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Xiao,H., Palhan,V., Yang,Y. and Roeder,R.G.
  TITLE     TIP30 has an intrinsic kinase activity required for up-regulation
            of a subset of apoptotic genes
  JOURNAL   EMBO J. 19 (5), 956-963 (2000)
   PUBMED   10698937
  REMARK    GeneRIF: TIP30/CC3 is a novel serine/threonine kinase that
            phosphorylates the C-terminal domain (CTD) of the largest RNA
            polymerase II subunit and induces the expression of apoptosis
            related genes Bad and Siva, as well as metastasis suppressor
            NM23-H2
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Whitman,S., Wang,X., Shalaby,R. and Shtivelman,E.
  TITLE     Alternatively spliced products CC3 and TC3 have opposing effects on
            apoptosis
  JOURNAL   Mol. Cell. Biol. 20 (2), 583-593 (2000)
   PUBMED   10611237
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Baker,M.E.
  TITLE     TIP30, a cofactor for HIV-1 Tat-activated transcription, is
            homologous to short-chain dehydrogenases/reductases
  JOURNAL   Curr. Biol. 9 (13), R471 (1999)
   PUBMED   10395547
  REMARK    GeneRIF: TIP30/CC3 is a member of the short-chain
            dehydrogenases/reductases (SDR) family and is associated with
            metastasis suppression
REFERENCE   6  (bases 1 to 1438)
  AUTHORS   Xiao,H., Tao,Y., Greenblatt,J. and Roeder,R.G.
  TITLE     A cofactor, TIP30, specifically enhances HIV-1 Tat-activated
            transcription
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2146-2151 (1998)
   PUBMED   9482853
REFERENCE   7  (bases 1 to 1438)
  AUTHORS   Shtivelman,E.
  TITLE     A link between metastasis and resistance to apoptosis of variant
            small cell lung carcinoma
  JOURNAL   Oncogene 14 (18), 2167-2173 (1997)
   PUBMED   9174052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC002439.2.
            On Aug 25, 2003 this sequence version replaced gi:20127502.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1438
                     /gene="HTATIP2"
                     /note="synonyms: CC3, TIP30"
                     /db_xref="GeneID:10553"
                     /db_xref="MIM:605628"
     CDS             113..841
                     /gene="HTATIP2"
                     /note="Tat-interacting protein (30kD); HIV-1 Tat
                     interactive protein 2, 30 kDa;
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     9482853];
                     go_function: transcription coactivator activity [goid
                     0003713] [evidence TAS] [pmid 9482853];
                     go_function: RNA polymerase II transcription factor
                     activity [goid 0003702] [evidence TAS] [pmid 9482853];
                     go_process: anti-apoptosis [goid 0006916] [evidence TAS]
                     [pmid 10611237];
                     go_process: induction of apoptosis [goid 0006917]
                     [evidence TAS] [pmid 9174052];
                     go_process: regulation of transcription from Pol II
                     promoter [goid 0006357] [evidence TAS] [pmid 9482853]"
                     /codon_start=1
                     /product="HIV-1 Tat interactive protein 2, 30kDa"
                     /protein_id="NP_006401.2"
                     /db_xref="GI:20127503"
                     /db_xref="GeneID:10553"
                     /db_xref="MIM:605628"
                     /translation="MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLF
                     SKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAE
                     GFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFD
                     RYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWARGHSVPVVTVVRAMLNNVVRPR
                     DKQMELLENKAIHDLGKAHGSLKP"
ORIGIN      
        1 ggatgctctg atggccgggc ctgcggcgct gagcgcggcg gcggcggctg ctctggcggc
       61 cgccctgctc ctgctgcgtc gtgaggaccc ggggccgggg gctggcccca gcatggccga
      121 aacagaagcc ctgtcgaagc ttcgggaaga cttcaggatg cagaataaat ccgtctttat
      181 tttgggcgcc agcggagaaa ccggcagagt gctcttaaag gaaatcctgg agcagggcct
      241 gttttccaaa gtcacgctca ttggccggag gaagctcacc ttcgacgagg aagcttataa
      301 aaatgtgaat caagaagtgg tggactttga aaagttggat gactacgcct ctgcctttca
      361 aggtcatgat gttggattct gttgcctggg taccaccaga gggaaagctg gggcggaggg
      421 atttgttcgt gttgaccgag attatgtgct gaagtctgca gagctggcaa aagctggagg
      481 gtgcaaacat ttcaacttgc tatcctctaa aggagctgat aaatcaagca attttttata
      541 tctacaagtt aagggagaag tagaagccaa ggttgaagaa ttaaaatttg atcgttactc
      601 tgtatttagg cctggagttc tgttatgtga taggcaagaa tctcgcccag gtgaatggct
      661 ggttagaaag ttctttggct ccttaccaga ctcttgggcc agggggcatt ctgtgcctgt
      721 ggtgaccgtg gttagagcaa tgctgaacaa tgtggtgaga ccaagagaca agcagatgga
      781 actgctggag aacaaggcca tccatgacct ggggaaagcg catggctctc tcaagccatg
      841 accacactgg agaaatggtt tttattgtca accttaacac ccatcaccaa atcggtaatt
      901 tcagggtcta aaaaaagtca gcatgtttta actttgttgt tttactatcc tcaggcatcc
      961 attccaatca agaaatgatg gtgctctgca tcagtggttc agagcctggt tatacatata
     1021 gatcactcag ggagctttgg aaaaataaag atttgtcagc cctatctcaa acttgaatca
     1081 aaatttctgg ggtgtgggca caataatctg taattttctt tgtttatact tcccctgatg
     1141 ccactggttc cgatgccact ggctgggggg cctgctttga aatgcttgtc tgcagagtca
     1201 cagcagccat gaaaacctta tgaccgtgca aatgagctct gctctaaaat tgttgacatt
     1261 catgtctctg agttacaaaa gtgctaattc actacatgta attgtgtaag taaacattgt
     1321 gcctttacta cttctttatg taatagaagt tatataccta agcttatata atacatgggg
     1381 aggattaaat aaaggaataa agatgaatgg acaactccaa aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_006467               1000 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens polymerase (RNA) III (DNA directed) polypeptide G
            (32kD) (POLR3G), mRNA.
ACCESSION   NM_006467
VERSION     NM_006467.1  GI:5454017
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1000)
  AUTHORS   Hu,P., Wu,S., Sun,Y., Yuan,C.C., Kobayashi,R., Myers,M.P. and
            Hernandez,N.
  TITLE     Characterization of human RNA polymerase III identifies orthologues
            for Saccharomyces cerevisiae RNA polymerase III subunits
  JOURNAL   Mol. Cell. Biol. 22 (22), 8044-8055 (2002)
   PUBMED   12391170
REFERENCE   2  (bases 1 to 1000)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     Three human RNA polymerase III-specific subunits form a subcomplex
            with a selective function in specific transcription initiation
  JOURNAL   Genes Dev. 11 (10), 1315-1326 (1997)
   PUBMED   9171375
REFERENCE   3  (bases 1 to 1000)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J. Acquir. Immune Defic. Syndr. 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U93868.1.
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..1000
                     /gene="POLR3G"
                     /note="synonyms: RPC7, RPC32"
                     /db_xref="GeneID:10622"
     CDS             163..864
                     /gene="POLR3G"
                     /note="polymerase (RNA) III (DNA directed) (32kD);
                     go_component: DNA-directed RNA polymerase III complex
                     [goid 0005666] [evidence TAS] [pmid 9171375];
                     go_function: DNA-directed RNA polymerase activity [goid
                     0003899] [evidence TAS] [pmid 9171375];
                     go_process: regulation of transcription from Pol III
                     promoter [goid 0006359] [evidence TAS] [pmid 9171375]"
                     /codon_start=1
                     /product="polymerase (RNA) III (DNA directed) polypeptide
                     G (32kD)"
                     /protein_id="NP_006458.1"
                     /db_xref="GI:5454018"
                     /db_xref="GeneID:10622"
                     /translation="MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYK
                     PVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYQEEWIPD
                     WRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMVELEKRGDGEKSDEE
                     NEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADVMTTW
                     MRQPIRHEIFQKIFL"
ORIGIN      
        1 cgaggtggac gggcggcagt caagcgccgg cgttctctgc catcaccctt tccttgccgg
       61 ccggcacttc ggctgcagag ttttgcccac gcttcgagac ttagggagca gtgcctttca
      121 gaatttcaga atttgcccac tcatctggta taactggttc tgatggctgg gaataaagga
      181 agaggacgtg ctgcttatac ctttaatatt gaggctgttg gatttagcaa aggtgaaaag
      241 ttacctgatg tagtgttgaa accaccccca ctatttcctg atacagatta taaaccagta
      301 ccactgaaaa caggagaagg tgaagaatat atgctggctt tgaaacagga gttgagagaa
      361 acaatgaaaa gaatgcctta ttttattgaa acacctgaag aaagacaaga tattgaaagg
      421 tatagtaaaa gatacatgaa ggtataccag gaagaatgga taccagattg gagaagactt
      481 ccaagagaga tgatgccaag aaataaatgt aaaaaagcag gcccaaaacc caaaaaggca
      541 aaagacgcag gcaaaggcac accactcact aatactgaag atgtgttgaa aaaaatggtg
      601 gaattggaaa aaagaggtga tggtgaaaaa tcagatgagg aaaatgaaga gaaagaagga
      661 agcaaagaga aaagtaaaga aggtgatgat gacgatgacg atgatgccgc agaacaggag
      721 gaatatgatg aagaagagca agaagaggaa aatgactaca ttaattcata ctttgaagat
      781 ggagatgatt ttggcgcaga cgtgatgaca acatggatga ggcaacctat taggcatgaa
      841 atttttcaaa aaatattttt atgatgcagc ttctgaacat ttggacagac ttgatttgta
      901 ttttatttct gataaggaat aagatcttgt ttctgttgtt ttggacaaaa tgttgttacc
      961 aaaatatcaa aaccactttg agtttacata cagttacctt
//

LOCUS       NM_006496               3143 bp    mRNA    linear   PRI 09-OCT-2004
DEFINITION  Homo sapiens guanine nucleotide binding protein (G protein), alpha
            inhibiting activity polypeptide 3 (GNAI3), mRNA.
ACCESSION   NM_006496
VERSION     NM_006496.1  GI:5729849
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3143)
  AUTHORS   Fischer,T., De Vries,L., Meerloo,T. and Farquhar,M.G.
  TITLE     Promotion of G alpha i3 subunit down-regulation by GIPN, a putative
            E3 ubiquitin ligase that interacts with RGS-GAIP
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8270-8275 (2003)
   PUBMED   12826607
  REMARK    GeneRIF: Overexpression of GIPN stimulates proteasome-dependent
            reduction of endogenous G alpha i3 in HEK293 cells and reduces the
            half-life of overexpressed G alpha i3-YFP.
REFERENCE   2  (bases 1 to 3143)
  AUTHORS   Miotti,S., Bagnoli,M., Tomassetti,A., Colnaghi,M.I. and Canevari,S.
  TITLE     Interaction of folate receptor with signaling molecules lyn and
            G(alpha)(i-3) in detergent-resistant complexes from the ovary
            carcinoma cell line IGROV1
  JOURNAL   J. Cell. Sci. 113 Pt 2, 349-357 (2000)
   PUBMED   10633085
REFERENCE   3  (bases 1 to 3143)
  AUTHORS   Downes,G.B. and Gautam,N.
  TITLE     The G protein subunit gene families
  JOURNAL   Genomics 62 (3), 544-552 (1999)
   PUBMED   10644457
REFERENCE   4  (bases 1 to 3143)
  AUTHORS   Migeon,J.C., Thomas,S.L. and Nathanson,N.M.
  TITLE     Differential coupling of m2 and m4 muscarinic receptors to
            inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits
  JOURNAL   J. Biol. Chem. 270 (27), 16070-16074 (1995)
   PUBMED   7608168
REFERENCE   5  (bases 1 to 3143)
  AUTHORS   Kim,S.Y., Ang,S.L., Bloch,D.B., Bloch,K.D., Kawahara,Y., Tolman,C.,
            Lee,R., Seidman,J.G. and Neer,E.J.
  TITLE     Identification of cDNA encoding an additional alpha subunit of a
            human GTP-binding protein: expression of three alpha i subtypes in
            human tissues and cell lines
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (12), 4153-4157 (1988)
   PUBMED   3132707
REFERENCE   6  (bases 1 to 3143)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J. Biol. Chem. 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   7  (bases 1 to 3143)
  AUTHORS   Codina,J., Olate,J., Abramowitz,J., Mattera,R., Cook,R.G. and
            Birnbaumer,L.
  TITLE     Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G
            protein of receptor-regulated K+ channels
  JOURNAL   J. Biol. Chem. 263 (14), 6746-6750 (1988)
   PUBMED   2452165
REFERENCE   8  (bases 1 to 3143)
  AUTHORS   Beals,C.R., Wilson,C.B. and Perlmutter,R.M.
  TITLE     A small multigene family encodes Gi signal-transduction proteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (22), 7886-7890 (1987)
   PUBMED   3120178
REFERENCE   9  (bases 1 to 3143)
  AUTHORS   Didsbury,J.R. and Snyderman,R.
  TITLE     Molecular cloning of a new human G protein. Evidence for two Gi
            alpha-like protein families
  JOURNAL   FEBS Lett. 219 (1), 259-263 (1987)
   PUBMED   3109953
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M27543.1.
FEATURES             Location/Qualifiers
     source          1..3143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13"
     gene            1..3143
                     /gene="GNAI3"
                     /note="synonym: 87U6"
                     /db_xref="GeneID:2773"
                     /db_xref="MIM:139370"
     CDS             43..1107
                     /gene="GNAI3"
                     /note="go_function: GTP binding [goid 0005525] [evidence
                     IEA];
                     go_function: GTPase activity [goid 0003924] [evidence TAS]
                     [pmid 3109953];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IEA];
                     go_process: transport [goid 0006810] [evidence NAS] [pmid
                     2452165];
                     go_process: signal transduction [goid 0007165] [evidence
                     IEA];
                     go_process: G-protein coupled receptor protein signaling
                     pathway [goid 0007186] [evidence IEA];
                     go_process: negative regulation of adenylate cyclase
                     activity [goid 0007194] [evidence TAS] [pmid 7608168]"
                     /codon_start=1
                     /product="guanine nucleotide binding protein (G protein),
                     alpha inhibiting activity polypeptide 3"
                     /protein_id="NP_006487.1"
                     /db_xref="GI:5729850"
                     /db_xref="GeneID:2773"
                     /db_xref="MIM:139370"
                     /translation="MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGES
                     GKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARAD
                     DARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLD
                     RISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGV
                     TAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEE
                     KIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQF
                     VFDAVTDVIIKNNLKECGLY"
ORIGIN      
        1 tgtgagtgag tccgggcccg tgtcccctct cccgccgccg ccatgggctg cacgttgagc
       61 gccgaagaca aggcggcagt ggagcgaagc aagatgatcg accgcaactt acgggaggac
      121 ggggaaaaag cggccaaaga agtgaagctg ctgctactcg gtgctggaga atctggtaaa
      181 agcaccattg tgaaacagat gaaaatcatt catgaggatg gctattcaga ggatgaatgt
      241 aaacaatata aagtagttgt ctacagcaat actatacagt ccatcattgc aatcataaga
      301 gccatgggac ggctaaagat tgactttggg gaagctgcca gggcagatga tgcccggcaa
      361 ttatttgttt tagctggcag tgctgaagaa ggagtcatga ctccagaact agcaggagtg
      421 attaaacggt tatggcgaga tggtggggta caagcttgct tcagcagatc cagggaatat
      481 cagctcaatg attctgcttc atattatcta aatgatctgg atagaatatc ccagtctaac
      541 tacattccaa ctcagcaaga tgttcttcgg acgagagtga agaccacagg cattgtagaa
      601 acacatttca ccttcaaaga cctatacttc aagatgtttg atgtaggtgg ccaaagatca
      661 gaacgaaaaa agtggattca ctgttttgag ggagtgacag caattatctt ctgtgtggcc
      721 ctcagtgatt atgaccttgt tctggctgag gacgaggaga tgaaccgaat gcatgaaagc
      781 atgaaactgt ttgacagcat ttgtaataac aaatggttta cagaaacttc aatcattctc
      841 ttccttaaca agaaagacct ttttgaggaa aaaataaaga ggagtccgtt aactatctgt
      901 tatccagaat acacaggttc caatacatat gaagaggcag ctgcctatat tcaatgccag
      961 tttgaagatc tgaacagaag aaaagatacc aaggagatct atactcactt cacctgtgcc
     1021 acagacacga agaatgtgca gtttgttttt gatgctgtta cagatgtcat cattaaaaac
     1081 aacttaaagg aatgtggact ttattgagaa gcatggatgt tagtgaaagt tactacagtg
     1141 tggagtgttg agaccagaca ccttttgctg tctcatgggg cagctacaag catgaacggg
     1201 accagggaat ggcagcagca tgcagaatct tagcactctt tagcacaata ttttgtatta
     1261 gggaactttt aattgacatc gagatgctaa agtcagacat tggaattgga agaactacta
     1321 aagtgtgatt cgatcgtcaa gacatcactt ggatttctta atcttaaatg cttatggaag
     1381 atgtgaagtt gaggtgctgc attctagaac ttcaatatgt agcttactct ttttttcccc
     1441 ccttcttaaa ccaccagtgg ttcattttta aggttttttc atcaagagaa gaataacttt
     1501 actaaatttt atttctttat ttgcaaaaga atctttatta aaacaaacaa tcttaactat
     1561 gcacatgatg tgaccagatc atcttgaaaa tattcctctt tagtaggaac tctttgtttt
     1621 taactcttgg tatggtcaga atataatact tccataatta cttataattc tttccggtta
     1681 ctggggctat aaatacaact ttttaaatga aatttatgtt attatcctgc tcaaagtacc
     1741 attatggttt ccatatggta attacattgg aaagttctgc aataagattc tagttctctc
     1801 ttttctttaa gcttatggtt gaaggttaac cttgtttgtg cagattacca aattactgct
     1861 gatgtagtat gataaagtca gcttcttgga tacagacaca cccagggcag ctgccaatca
     1921 gaaatgcaaa ttgctaaatt ccaaacagaa ccagtgactt tgctgctaca tatttactaa
     1981 attgaccact ttgattcttg cttgtttgtc tcagttatag ggagttttgt acatggtgcc
     2041 tcttgttttc catcttcatg gccttttctg ttgagaaaca tctaaagtgt attaacagtg
     2101 catgctttta ctttgtaaat gtggtgccaa atccctgttt gccatcgttt ttactgtacc
     2161 gatgttaact gtagtaatcc ttagccagta tgttcttttg ctgaaactgt tgcattttgg
     2221 gacttttttc cactttgtca tgtgtacatt tttaatctgt tatagttggc ggcagtatta
     2281 aaatggtgag taaagagccc aggtttgctc ctgtttgtaa ctagtctttt ctggaaatac
     2341 tgtcttctgt ttccttttgc ctttgcagaa tgtgctttag cctttgtctg agaatgggtt
     2401 taggtagaag ggtttcctga aagtctagtc ttttggtgta atagtattgt tgaaccttag
     2461 gttttatgtt atatctgcat atgagtgata tgtgatcatg attcattttg cagatttaca
     2521 ttttgcttgt gtggaaagtt acgttcactt caacctacag acccttttgt ataatgtaca
     2581 gcaaatgtca ttaaatattg aatgctctat tgggggaaga caaatgaaga gaatgcattt
     2641 tgagcatttc aaatcagtag tttgggcagt gccttttggg gtccaatctt tttggattgg
     2701 attctatttc atcttttgat gtgacttttc acctagttta caaaaaaaag gttggtggtc
     2761 aacaaaaaaa gcaagtcata gcagttcagt gcctttgttg gtagttttta actttttttg
     2821 tgattctttt tggaaaatca tagcttacag atggtataac tgtattatat aatggaattt
     2881 tctttaggtg tgggaaaaac ttgatctgaa agaaaattat cagcttcaat tggcgattga
     2941 ttcagtgccc acaatgtaaa cagggttggt agttgttact cattttgaat ataccttttc
     3001 cttattgtat tctgtaatat aggatcctgg aaatgagacc tggtggaata ttattttcaa
     3061 ctgtagtctt tctatactgt ggactaatga aatggtgttg ttgataaatc taaaataacc
     3121 aataatccaa aaaagttcat ttt
//

LOCUS       NM_006663               2620 bp    mRNA    linear   PRI 24-JAN-2005
DEFINITION  Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit
            13 like (PPP1R13L), mRNA.
ACCESSION   NM_006663
VERSION     NM_006663.1  GI:5730000
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2620)
  AUTHORS   Takada,N., Sanda,T., Okamoto,H., Yang,J.P., Asamitsu,K., Sarol,L.,
            Kimura,G., Uranishi,H., Tetsuka,T. and Okamoto,T.
  TITLE     RelA-associated inhibitor blocks transcription of human
            immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1
            actions
  JOURNAL   J. Virol. 76 (16), 8019-8030 (2002)
  MEDLINE   22129221
   PUBMED   12134007
  REMARK    GeneRIF: Effect of RAI on transcription and replication of human
            immunodeficiency virus type 1 (HIV-1).
REFERENCE   2  (bases 1 to 2620)
  AUTHORS   Yang,J.P., Hori,M., Sanda,T. and Okamoto,T.
  TITLE     Identification of a novel inhibitor of nuclear factor-kappaB,
            RelA-associated inhibitor
  JOURNAL   J. Biol. Chem. 274 (22), 15662-15670 (1999)
  MEDLINE   99269105
   PUBMED   10336463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF078037.1.
FEATURES             Location/Qualifiers
     source          1..2620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2620
                     /gene="PPP1R13L"
                     /note="synonyms: RAI, IASPP, NKIP1"
                     /db_xref="GeneID:10848"
                     /db_xref="MIM:607463"
     CDS             944..1999
                     /gene="PPP1R13L"
                     /note="RelA-associated inhibitor; NFkB interacting protein
                     1;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_process: apoptosis [goid 0006915] [evidence IEA];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="protein phosphatase 1, regulatory (inhibitor)
                     subunit 13 like"
                     /protein_id="NP_006654.1"
                     /db_xref="GI:5730001"
                     /db_xref="GeneID:10848"
                     /db_xref="MIM:607463"
                     /translation="MWMKDPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPL
                     KRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGRSQSCPPSLRDLRPGQGP
                     LLLPHQLPFHRPAPSQSSPPEQPQSMEMRSVLRKAGSPRKARRARLNPLVLLLDAALT
                     GELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWT
                     PLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQ
                     SMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVP
                     RNYFGLFPRVKPQRSKV"
ORIGIN      
        1 gcggccgcgt cgacaaacaa gtgagtctcg gctggagtgc agtggtgcag tggtgcaatc
       61 tcggctcact gcaacctccg cctcctgggt tcaagcgatt cctgtgcctc ggccttccga
      121 gtagctggga ttgcaggcgt gtgccaccac gcccggctaa tttttttttt tttttttttt
      181 tttttgtatt tttagtagag acagggttct taccatgttg gccaggctgg tctcaaactc
      241 ctgatctcaa gagatgtggc ctgcctccgg cctcccaaag ttctgggatt acagggtgtt
      301 gagccactct gactcagcca ataatgcata tttttatttc cacctgcttt actgtcagaa
      361 tgagtaagac agagaagaaa tcattaaaca ccaggattct acttgcctgc tggagttttc
      421 tgcctgagat gttaggagag gaaactctca ggatctcaga aaatcacatc tatcacggtt
      481 ggtagaagta gattctagag tcagccagaa tgagttcaag tcccaactgc atggctttgg
      541 gcaactgact gtcctctctg aggcccagat tccctttcgg taatgtggag atggcagtgt
      601 atctacctca caaagcagtg gtgagattac aataaggtag gcatgtaaag cgccaggcac
      661 atactaactg ctcaataaat gggaggcatc ataattgtat attattcaca gcccaaggaa
      721 agtgtagccc agagagggca aggaacttga ccctgaggtc aacacagaaa atcatgtgct
      781 ggttgtatgc cctggaagtt gtggagaggg agtgttgggt gtcttcctgg ggacctgtcc
      841 tctgatgggc tcttgttccg gctaggaccc cccaaacccc ccaccgagct ggagcctgag
      901 ccggagatag aggggctgct gacaccagtg ctggaggctg gcgatgtgga tgaaggaccc
      961 tgtagcaagg cctctcagcc ccacgaggct gcagccagca ctgccaccgg aggcacagtc
     1021 ggtgcccgag ctggaggagg tggcacgggt gttggcggaa attccccggc ccctcaaacg
     1081 caggggctcc atggagcagg cccctgctgt ggccctgccc cctacccaca agaaacagta
     1141 ccagcagatc atcagccgcc tcttccatcg tcatgggggg ccagggcccg gggggcggag
     1201 ccagagctgt cccccatcac tgagggatct gaggccaggg cagggccccc tgctcctgcc
     1261 ccaccagctc ccattccacc gcccggcccc gtcccagagc agcccaccag agcagccgca
     1321 gagcatggag atgcgctctg tgctgcggaa ggcgggctcc ccgcgcaagg cccgccgcgc
     1381 gcgcctcaac cctctggtgc tcctcctgga cgcggcgctg accggggagc tggaggtggt
     1441 gcagcaggcg gtgaaggaga tgaacgaccc gagccagccc aacgaggagg gcatcactgc
     1501 cttgcacaac gccatctgcg gcgccaacta ctctatcgtg gatttcctca tcaccgcggg
     1561 tgccaatgtc aactcccccg acagccacgg ctggacaccc ttgcactgcg cggcgtcgtg
     1621 caacgacaca gtcatctgca tggcgctggt gcagcacggc gctgcaatct tcgccaccac
     1681 gctcagcgac ggcgccaccg ccttcgagaa gtgcgaccct taccgcgagg gttatgctga
     1741 ctgcgccacc tacctggcag acgtcgagca gagtatgggg ctgatgaaca gcggggcagt
     1801 gtacgctctc tgggactaca gcgccgagtt cggggacgag ctgtccttcc gcgagggcga
     1861 gtcggtcacc gtgctgcgga gggacgggcc ggaggagacc gactggtggt gggccgcgct
     1921 gcacggccag gagggctacg tgccgcggaa ctacttcggg ctgttcccca gggtgaagcc
     1981 tcaaaggagt aaagtctagc aggatagaag gaggtttctg aggctgacag aaacaagcat
     2041 tcctgccttc cctccagacc tctccctctg ttttttgctg cctttatctg cacccctcac
     2101 cctgctggtg gtggtccttg ccaccggttc tctgttctcc tggaagtcca gggaagaagg
     2161 agggccccag ccttaaattt agtaatctgc cttagccttg ggaggtctgg gaagggctgg
     2221 aaatcactgg ggacaggaaa ccacttcctt ttgccaaatc agatcccgtc caaagtgcct
     2281 cccatgccta ccaccatcat cacatccccc agcaagccag ccacctgccc agccgggcct
     2341 gggatgggcc accacaccac tggatattcc tgggagtcac tgctgacacc atctctccca
     2401 gcagtcttgg ggtctgggtg ggaaacattg gtctctacca ggatccctgc cccacctctc
     2461 cccaattaag tgccttcaca cagcactggt ttaatgttta taaacaaaat agagaaactt
     2521 tccttataaa taaaagtagt ttgcacagaa aaaaaaaaaa cacaaccttc ggccgcccca
     2581 ccaagctctg tctccaaaaa aaaaaaaaaa aaaaaaaaaa
//

LOCUS       NM_006751               4978 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens sperm specific antigen 2 (SSFA2), mRNA.
ACCESSION   NM_006751
VERSION     NM_006751.3  GI:34222128
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Inokuchi,J., Komiya,M., Baba,I., Naito,S., Sasazuki,T. and
            Shirasawa,S.
  TITLE     Deregulated expression of KRAP, a novel gene encoding
            actin-interacting protein, in human colon cancer cells
  JOURNAL   J. Hum. Genet. 49 (1), 46-52 (2004)
   PUBMED   14673706
  REMARK    GeneRIF: localized as a membrane-bound form with extracellular
            regions; results suggested KRAP might be involved in the regulation
            of filamentous actin and signals from the outside of the cells
REFERENCE   2  (bases 1 to 4978)
  AUTHORS   Javed,A.A. and Naz,R.K.
  TITLE     Human cleavage signal-1 protein; cDNA cloning, transcription and
            immunological analysis
  JOURNAL   Gene 112 (2), 205-211 (1992)
   PUBMED   1555770
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC028706.2.
            On Aug 26, 2003 this sequence version replaced gi:28557787.
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.3"
     gene            1..4978
                     /gene="SSFA2"
                     /note="synonyms: CS1, CS-1, KRAP, SPAG13, KIAA1927"
                     /db_xref="GeneID:6744"
                     /db_xref="MIM:118990"
     CDS             113..3883
                     /gene="SSFA2"
                     /note="go_component: plasma membrane [goid 0005886]
                     [evidence NAS] [pmid 1555770]"
                     /codon_start=1
                     /product="sperm specific antigen 2"
                     /protein_id="NP_006742.2"
                     /db_xref="GI:28557788"
                     /db_xref="GeneID:6744"
                     /db_xref="MIM:118990"
                     /translation="MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLST
                     EATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLK
                     GVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSG
                     KSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKV
                     FLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTS
                     NKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEE
                     SGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTE
                     NEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAP
                     LTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDS
                     SGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNE
                     SEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEV
                     EEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTT
                     GPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSL
                     PTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKS
                     TIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQER
                     PLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLR
                     RVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFR
                     TQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLE
                     EQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLG
                     LGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARK
                     KVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSM
                     PAAEEMHKNVEQDELQQVIREVGMDPISCVILELSMICTGGGVICALEDTCC"
ORIGIN      
        1 agctccccgg ggccccctgc ccggccgggc gctgacagca agggcggggg tccctgccgc
       61 cgccttgtct cgcgcagggt ccggctgggg tagcggagcc cccagtgcgg ccatggaccg
      121 gcccctgtcg tcgtcggcgg aggcggagga ggaactggag tggcaagtgg cgagtcgcag
      181 gaggaaggcc tgggccaagt gccgcagctc ctggcaagcg tcggagacgg aggatctgtc
      241 cacagaagcg acgacgcagg acgaggagga ggacgaggag gaggacctcc ccggcgcgca
      301 gctgccggca gcggggggaa gaggaaacgt gcccaacgag aagatcgcga tatggctcaa
      361 ggactgccgt acacctttgg gagcctcact ggatgaacaa agcagtagta cactcaaggg
      421 tgtgcttgtg agaaatggag gaagttttga agatgatttg tcattgggag ctgaagccaa
      481 ccacctccat gaaagtgatg ctcaaattga aaactgcaat aatatcttgg ccaaagagag
      541 aagattacag tttcatcaga aagggagaag tatgaattcc actggatctg ggaaaagtag
      601 tgggacagtt tcaagtgttt cagaattgtt ggaactttat gaggaagatc ctgaagaaat
      661 tctttataat cttggatttg gacgtgatga accagatatt gcttctaaaa ttccttccag
      721 attttttaat tcatcatcct ttgccaaagg gatagatatt aaagtatttt tgagtgctca
      781 gatgcaacgg atggaagtag aaaacccaaa ttatgcttta acaagccgtt ttcgtcaaat
      841 tgaagtgctt actactgtgg ccaatgcgtt ttcttcttta tattctcaag tctccgggac
      901 gcccctgcag agaattggaa gtatgtcctc agtgacctct aacaaggaga cagacccacc
      961 tccaccttta actcgaagta acactgcaaa tcgtttaatg aaaacactct caaaactgaa
     1021 tttatgtgtt gataaaacag agaaaggaga aagtagtagt ccttctccat cagctgaaaa
     1081 aggaaagatt ctaaatgttt cagtgattga agaaagtggc aataaaaacg atcaaaagtc
     1141 tcaaaaaatt atgaagaaga aagagtcatc ttctatgttg gctacagtta aagaagaagt
     1201 ctctggtagt tcagcagctg ttacggagaa tgctgatagt gatagaattt ctgatgaagc
     1261 aaatagtaat tttaaccaag gaactgaaaa tgaacaaagt aaagaaactc aaagtcatga
     1321 gagtaaactg ggtgaggaat ctggtattgt agaatccaaa ttagatagtg atttcaacat
     1381 atccagccac agtgagctgg aaaatagcag tgagctgaaa agtgtccata tatccacacc
     1441 tgaaaaagag ccttgtgcac cactgacaat accatccata agaaatataa tgacacagca
     1501 gaaggactcc ttcgaaatgg aagaggttca aagtacggag ggagaagctc ctcatgttcc
     1561 agccacttac cagctaggtc ttacgaagtc gaaaagagat catctgttac gtactgcaag
     1621 tcagcattcc gatagcagtg gttttgctga agattctaca gactgcctat cccttaatca
     1681 tcttcaggtt caggagtcct tgcaggctat ggggagtagt gctgatagtt gtgacagtga
     1741 gacaacagtt acgtcacttg gtgaagacct tgccacacca acagcacaag accagcctta
     1801 ttttaatgaa tcagaggagg agtctcttgt ccctcttcag aagggactag agaaggcagc
     1861 agcagttgca gacaaaagaa aatcaggtag ccaggatttc cctcagtgca acaccattga
     1921 gaatacagga actaaacagt ccacctgtag tccaggggat catatcattg aaattactga
     1981 agtggaagag gatttgtttc cagcagagac agtagagcta ctgagggaag caagtgctga
     2041 aagtgatgtg ggtaaaagca gtgaaagtga atttactcag tataccacac accatattct
     2101 gaaatcattg gcttctattg aagctaaatg cagtgatatg agctctgaaa atacaactgg
     2161 gcctccctct tccatggaca gagttaatac agctttgcaa agagctcaaa tgaaggtttg
     2221 cagtctgtct aatcaaagga tggggcgtag cctgctaaaa tcaaaagatt tgttaaaaca
     2281 aaggtactta tttgcaaaag ctggctatcc tctaagaagg tctcagtctt taccaaccac
     2341 cttattgagc ccagtaaggg ttgtgtcctc tgtcaatgtt cgattatctc caggaaaaga
     2401 gaccagatgc agcccacctt ccttcaccta taagtacaca cctgaagagg agcaggaatt
     2461 ggaaaagcgg gtgatggaac atgatggtca gtctttagtt aaatcgacca ttttcatctc
     2521 tccatcatct gtgaagaaag aagaagcccc ccagagtgag gcgccgcggg tggaggaatg
     2581 ccatcatgga aggactccta cctgttcacg gcttgctcca ccaccaatgt ctcagtctac
     2641 ctgttccctt cattccatcc actctgagtg gcaagaaagg cccctgtgtg agcacacaag
     2701 aactctgagc actcacagtg ttcccaacat atcaggggct acttgtagtg ccttcgcttc
     2761 ccctttcggg tgtccttact cacatagaca tgccacctac ccttaccgag tgtgctctgt
     2821 gaatcctcct tcagccatag aaatgcagtt gcgaagagta ttacatgata ttagaaactc
     2881 actgcagaat ctttcacagt accctatgat gagaggacct gatcctgctg ctgctccata
     2941 tagtactcag aaatcatctg ttctacctct ttatgaaaat acttttcagg agctccaggt
     3001 aatgaggcgg agcctgaatt tgtttagaac acaaatgatg gatttagaat tggcaatgct
     3061 gcgtcagcaa accatggttt atcatcatat gactgaggag gagaggtttg aagttgatca
     3121 gctccagggt ttgagaaatt cagtccgaat ggaacttcag gacctggaac tgcagctgga
     3181 ggagcgcctg ctgggcctgg aggaacagct tcgtgctgtg cgcatgcctt cacccttccg
     3241 ctcctccgca ctcatgggaa tgtgtggcag tagaagcgct gataacttgt catgcccttc
     3301 tccattgaat gtaatggaac cagtcactga actgatgcag gagcagtcat acctgaagtc
     3361 tgaattgggc ctgggacttg gagaaatggg atttgaaatt cctcctggag aaagctcaga
     3421 atctgttttt tcccaagcaa catcagaatc atcttctgta tgttctggtc cctctcatgc
     3481 taacagaaga actggagtac cttctactgc ctcagtgggc aaatccaaaa ccccattagt
     3541 ggcaaggaag aaagtgttcc gagcatcggt ggctctaacg ccaacagctc cttctagaac
     3601 aggctctgtg cagacacctc cagatttgga aagttctgag gaagttgatg cagctgaagg
     3661 agccccagaa gttgtaggac ctaaatctga agtggaagaa gggcatggaa aactcccatc
     3721 aatgccagct gctgaggaaa tgcataaaaa tgtggagcaa gatgagttgc agcaagtcat
     3781 acgggaggtt ggcatggatc ctattagctg tgtaatactg gaattatcaa tgatatgcac
     3841 tggtggaggt gttatttgtg ctttagaaga tacttgctgt tgagctgggc tactgtatac
     3901 agtgtacaat gtgtatttct tcaaccatat attttaaaaa gacgtacata gaaacttagg
     3961 cactttgcta tttcttttct aaactatcaa aaactctagc agtttgaaaa gcctaatatt
     4021 tatttgtatg tcaatatttt tcatttgatt ccctattaga attaatttta aaacttgaag
     4081 acttccagac ttatccaact tataaataac atatttcttc agactaacat cttaaaacac
     4141 tgacctctat gaggtattta ctgtgcaata actgattcat ttttttcaga gcttgaagca
     4201 tccaatgatt tttccctcca ctgctgttaa ttaatgtcac ttccaagaag aaaaactgtt
     4261 ctgttgtaaa aaatataatt gctcttaatt cttggggagg ttactaatag cagtaggata
     4321 gaattttatg aggttaccta caactactta acgtacttac actgtaagcc ttgttgcttt
     4381 acccaagaca aatgtaattt tatcattgct tatgtagtat ttttcttttg gaaatgtgcc
     4441 ttatgttaaa cactatgtac ttttactttt tgcattgtcc agacttcttt attagatgga
     4501 gatgtttctt tttctgtctt ctagactaaa tagagtatca tccaaataat ggggcctatg
     4561 acttgaatga atagaaatga ataagctggt gtttgttttt tcaaaatgga agtaatttag
     4621 atttgttctc ctcatacata aaatgatttt agttcagttt taaccagtga aaactttgtt
     4681 tttatgaaaa aaaaggaaaa tggtttccca tttggtttta tatgtgttaa ataaatgtgt
     4741 aaagtaacca ccaaatgtta ttagaatttt tcttctagca tttataattt tttcaactcc
     4801 tattgtgttt ctttgtgtgt gatattttaa tcaaaagtgg ttgagttgtt aacagtgttc
     4861 tttgaaagaa tctctaaaag gcttataaat gtttgaaata tcacacaaag gctgatttct
     4921 aaaatatata tatattaaaa caataaagta tttattttgc ccaaaaaaaa aaaaaaaa
//

LOCUS       NM_006754               2183 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens synaptophysin-like protein (SYPL), transcript variant
            1, mRNA.
ACCESSION   NM_006754
VERSION     NM_006754.2  GI:33239441
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Leube,R.E.
  TITLE     Expression of the synaptophysin gene family is not restricted to
            neuronal and neuroendocrine differentiation in rat and human
  JOURNAL   Differentiation 56 (3), 163-171 (1994)
   PUBMED   8034131
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Zhong,C.Z., Hayzer,D.J. and Runge,M.S.
  TITLE     Molecular cloning of a cDNA encoding a novel protein related to the
            neuronal vesicle protein synaptophysin
  JOURNAL   Biochim. Biophys. Acta 1129 (2), 235-238 (1992)
   PUBMED   1730063
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from X68194.1, BG719851.1,
            BQ429369.1, BC016835.1 and AA969654.1.
            On Jul 25, 2003 this sequence version replaced gi:5803184.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2183
                     /gene="SYPL"
                     /note="synonym: H-SP1"
                     /db_xref="GeneID:6856"
     CDS             83..862
                     /gene="SYPL"
                     /note="isoform a is encoded by transcript variant 1;
                     pantophysin;
                     go_component: synaptic vesicle [goid 0008021] [evidence
                     NR];
                     go_component: integral to plasma membrane [goid 0005887]
                     [evidence TAS] [pmid 8034131];
                     go_function: transporter activity [goid 0005215] [evidence
                     IEA];
                     go_process: transport [goid 0006810] [evidence IEA];
                     go_process: synaptic transmission [goid 0007268] [evidence
                     TAS] [pmid 8034131]"
                     /codon_start=1
                     /product="synaptophysin-like protein isoform a"
                     /protein_id="NP_006745.1"
                     /db_xref="GI:5803185"
                     /db_xref="GeneID:6856"
                     /translation="MAPNIYLVRQRISRLGQRMSGFQINLNPLKEPLGFIKVLEWIAS
                     IFAFATCGGFKGQTEIQVNCPPAVTENKTVTATFGYPFRLNEASFQPPPGVNICDVNW
                     KDYVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSLYLDSRKLPMIDFVVTLVA
                     TFLWLVSTSAWAKALTDIKIATGHNIIDELPPCKKKAVLCYFGSVTSMGSLNVSVIFG
                     FLNMILWGGNAWFVYKETSLHSPSNTSAPHSQGGIPPPTGI"
     polyA_signal    2143..2148
                     /gene="SYPL"
     polyA_site      2160
                     /gene="SYPL"
                     /evidence=experimental
ORIGIN      
        1 gagcgcacgc gtacacgcgt gcgcagggga agaccgagtg ccaggggctg aaccgcaggg
       61 aagggggcgc ggcgcacgca gtatggcgcc caacatctac ttggttcgcc agcggatcag
      121 tcgactcggc cagaggatgt ccggcttcca gatcaacctc aacccgctca aggagccact
      181 cggcttcatc aaggtcctcg agtggattgc ttctatcttt gcttttgcca cctgtggagg
      241 ttttaagggc caaacagaaa ttcaagtgaa ttgtcctcct gcagttactg agaataaaac
      301 tgttacagct acttttggtt atccattcag gttgaatgag gcatcatttc agccacctcc
      361 aggtgtaaac atatgtgatg taaattggaa agattacgtc ctcataggcg attactcttc
      421 ttctgcacaa ttctatgtta cctttgcagt ctttgtgttc ctgtactgca ttgctgccct
      481 tctgctttat gttggctaca cgagtctgta tctggatagt cgtaaacttc ctatgataga
      541 ctttgttgtt acacttgttg ccactttttt gtggttggtg agcacttcag cctgggctaa
      601 agctctgaca gatattaaaa tagctactgg tcacaatatt attgatgaac ttccgccttg
      661 taagaagaaa gcagtactgt gttactttgg ctctgtgacc agtatgggat ccctaaatgt
      721 atctgtgata tttggctttc taaatatgat actctgggga ggaaatgctt ggtttgtgta
      781 caaggagacc agcctacaca gtccatcaaa tacatctgcc cctcatagcc aaggaggtat
      841 tccacctcct accggaatat aattaaaggg agaaatacac tgtatgaagt atatgttgat
      901 actatgacat gttgccaaca ccttgagaag cattatttgt ttctaataaa agtaatggct
      961 ttgtcaatat attggtgggt ttaaaacttt gctgcttttt tacataaagc ctgtgccttt
     1021 cctagaaagt taagatgtaa atgtattctc acatgtaaat ttgaaagttc aggggtctat
     1081 tatgaaatga tacacatttt taaatgaacc ataatttttt tcactaagct gtttgccttc
     1141 caaagtgttt acaccttaag ccttaacatg tatcttcatt cagaaaacag ttatattgtc
     1201 ataccatagt aggaagaaaa acctttattt ggaatataca ctactgtaag tttgtacaga
     1261 tcatatacct accacctgtc tttgcttaaa gagccttgat tacataaata tgtaggaaaa
     1321 aacatattga gttcaaaatt tatatctaac attgtttatg ttatgatttt tttttaattg
     1381 caaagactag gtgtatattt ttttctgttt ttctaaatga cccgtggtac ttaataggtg
     1441 tactaaaatt gtgttgggag cagggatttg gaaatttctg agagatgtgt agttaattta
     1501 gtaattctgt ttcatgagat atgatctgtt atgctagtgg tttaataggc ttgctatgta
     1561 agtagaacgt ggctcaacta gatatcttta tatgtatggg cattactctt agtgatattt
     1621 gtttcctgtc ctttgttgct catgctgttt aagtgcaggc tgagacccag cctctttgta
     1681 agtacagtaa aataatccac cgttttttac agaccctagt caaagggtta aaaaaattaa
     1741 gattgctttc catgtttgaa atttaccatt gagagtcaat gaagttgcta ttttgagttt
     1801 agcattgata ttgtgaaaat aagtgcaatt tggatttcat gtttcttaat attcattctt
     1861 gtttcacaaa tgaatgatta aggaattatg catcataaag gaacctaagt gaggtatatg
     1921 atgagtgtat tgtctttgca cacacatata ggtatattct gaatacaagc ttattcacat
     1981 tttgcttcct aatctttttg ttgtacaggg attcaggttt cttattctta caacatgatt
     2041 gtttatatgt gaagcacatc ttgctgttgc cttatttttg atgcttttat tcatgacaag
     2101 aattgtcaat ataagaatgt atatcttttt tgcaaccaat ttaataaagg agttgaaaga
     2161 aaaaaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_006764               2045 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens interferon-related developmental regulator 2 (IFRD2),
            mRNA.
ACCESSION   NM_006764
VERSION     NM_006764.3  GI:48255963
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res. 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Buanne,P., Incerti,B., Guardavaccaro,D., Avvantaggiato,V.,
            Simeone,A. and Tirone,F.
  TITLE     Cloning of the human interferon-related developmental regulator
            (IFRD1) gene coding for the PC4 protein, a member of a novel family
            of developmentally regulated genes
  JOURNAL   Genomics 51 (2), 233-242 (1998)
   PUBMED   9722946
  REMARK    GeneRIF: This publication discusses both IFRD1 and IFRD2.
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Latif,F., Duh,F.M., Bader,S., Sekido,Y., Li,H., Geil,L., Zbar,B.,
            Minna,J.D. and Lerman,M.I.
  TITLE     The human homolog of the rodent immediate early response genes, PC4
            and TIS7, resides in the lung cancer tumor suppressor gene region
            on chromosome 3p21
  JOURNAL   Hum. Genet. 99 (3), 334-341 (1997)
   PUBMED   9050919
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from Y12395.1, BI825477.1,
            BC007265.1, BC001676.2 and AI292274.1.
            On Jun 4, 2004 this sequence version replaced gi:21361365.
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.3"
     gene            1..2045
                     /gene="IFRD2"
                     /note="synonyms: SM15, IFNRP, SKMc15"
                     /db_xref="GeneID:7866"
                     /db_xref="MIM:602725"
     CDS             215..1543
                     /gene="IFRD2"
                     /note="interferon-related protein"
                     /codon_start=1
                     /product="interferon-related developmental regulator 2"
                     /protein_id="NP_006755.3"
                     /db_xref="GI:48255964"
                     /db_xref="GeneID:7866"
                     /db_xref="MIM:602725"
                     /translation="MPRARKGNTLRKGGQRRGGGARSSAQADSGSSDDEAASEARSTA
                     SECPSLLSTTAEDSLGGDVVDEQGQQEDLEEKLKEYVDCLTDKSAKTRQGALESLRLA
                     LASRLLPDFLLERRLTLADALEKCLKKGKGEEQALAAAVLGLLCVQLGPGPKGEELFH
                     SLQPLLVSVLSDSTASPAARLHCASALGLGCYVAAADIQDLVSCLACLESVFSRFYGL
                     GGSSTSPVVPASLHGLLSAALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNL
                     RIAAGETIALLFELARDLEEEFVYEDMEALCSVLRTLATDSNKYRAKADRRRQRSTFR
                     AVLHSVEGGECEEEIVRFGFEVLYMDSWARHRIYAAFKEVLGSGMHHHLQNNELLRDI
                     FGLGPVLLLDATALKACKVPRFEKHLYNAAAFKARTKARSRVRDKRADIL"
ORIGIN      
        1 cgtggatgtg ggcctgaatc ggatggcctg gaactcgcct tcccggcgac ctgtttggca
       61 gggcggggcg cctcgcgaag atggtggcgc gcgtggcgtg tggctcccgt cgtctggcca
      121 agtctcagcg cagcgcaccg gccggcgtct cgttggcctg gagcccacac ccaccgggtc
      181 cctgaccccg cgccccccgc gcccggttcc cggcatgcct cgcgcccgta agggcaacac
      241 gctccggaag ggtggtcagc gccgtggagg aggtgcccgg agcagtgccc aagctgactc
      301 gggttccagt gacgatgagg cagccagtga ggcccgcagc accgccagtg aatgccccag
      361 ccttctcagc accactgcag aggacagcct tgggggggat gtcgtggatg agcagggcca
      421 gcaggaagac cttgaggaaa agctgaagga gtatgtggac tgtctcacag acaagagtgc
      481 caagacccgg cagggtgctc ttgagagcct gcgcctggcc ctagcgtccc gcctactccc
      541 cgacttcttg ctggagcgcc gcctcacgct agccgatgcc ctggaaaagt gcctcaagaa
      601 agggaagggc gaggaacaag ccctggctgc tgctgtgcta ggcctgctct gcgtgcagct
      661 gggccctgga cctaagggtg aggagctgtt tcacagcctg cagcctctgc tggtctctgt
      721 gctcagtgac agcacagcta gccctgctgc ccggctccac tgtgcttctg cccttggcct
      781 gggctgctac gtggctgccg ctgacatcca ggacctggtc tcttgccttg cctgcttaga
      841 aagtgttttc agccggttct atggcttggg gggcagctcc acaagtcctg tggttcctgc
      901 cagcctgcac ggcctgctct ctgctgccct gcaggcctgg gcattgctgc tcaccatctg
      961 ccctagcacc caaatcagcc acatccttga caggcagctg ccccggctgc cccagctctt
     1021 gtccagtgaa agtgtgaacc tgcggatcgc tgccggtgaa accattgcac tgctctttga
     1081 gcttgcccgg gaccttgagg aggagtttgt ttacgaggac atggaggccc tctgcagtgt
     1141 cctgcgcact ctggccactg acagtaacaa gtaccgtgcc aaggctgatc gtcggcgcca
     1201 gcgctctact ttccgcgccg tgctgcactc cgtggagggc ggtgaatgcg aagaagagat
     1261 agtgcgcttc ggctttgagg tgctctacat ggacagctgg gctcggcacc ggatctacgc
     1321 tgccttcaag gaagtgctgg gttcgggcat gcaccaccac ctccagaaca atgagctact
     1381 ccgtgacatc tttggcctgg gccctgtgct gttgctggat gccactgccc tgaaggcctg
     1441 caaggttcca cgctttgaga agcacctgta caatgctgct gccttcaaag cccggaccaa
     1501 ggctcgaagc cgtgtgcggg acaagcgggc agacatcctg tgaagcagga cctgctgaag
     1561 aggagacttt ctatgccctt ggtccgtatt tttaacagaa gacagtgcaa caactggtct
     1621 ccaccagtat ttgtcacttt atttttttta atgacaaaac caaaaacaga catggggtgg
     1681 gtagctgggg gcccggacac ttgggaccct gacccctttg tccctgcact cagccctgtg
     1741 gccccttcct gtcctgtctc aggccaggct aaatatgtgc cttcctcagg gctgtggggc
     1801 aggcactagg gggcctttcc cttcctttcc tttctcaggc cttgctcccc caggatgacc
     1861 cactcttagg ggggtggtgg catctggaca aatgccacca cagcaggtgg ggtggcaaag
     1921 ctacctggaa tggatttgtg tgctgatttt taaggattat tacagataat taaacagaac
     1981 ggtcagcctt ctgtggtctt aacccctggg tatttttctg ttctccctcc ccatctacta
     2041 tccca
//

LOCUS       NM_006806               1378 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens BTG family, member 3 (BTG3), mRNA.
ACCESSION   NM_006806
VERSION     NM_006806.3  GI:28872721
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Yoshida,Y., Hosoda,E., Nakamura,T. and Yamamoto,T.
  TITLE     Association of ANA, a member of the antiproliferative Tob family
            proteins, with a Caf1 component of the CCR4 transcriptional
            regulatory complex
  JOURNAL   Jpn. J. Cancer Res. 92 (6), 592-596 (2001)
   PUBMED   11429045
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Matsuda,S., Rouault,J., Magaud,J. and Berthet,C.
  TITLE     In search of a function for the TIS21/PC3/BTG1/TOB family
  JOURNAL   FEBS Lett. 497 (2-3), 67-72 (2001)
   PUBMED   11377414
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Yoshida,Y., Matsuda,S., Ikematsu,N., Kawamura-Tsuzuku,J.,
            Inazawa,J., Umemori,H. and Yamamoto,T.
  TITLE     ANA, a novel member of Tob/BTG1 family, is expressed in the
            ventricular zone of the developing central nervous system
  JOURNAL   Oncogene 16 (20), 2687-2693 (1998)
   PUBMED   9632145
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D64110.1 and BC011957.1.
            On Mar 6, 2003 this sequence version replaced gi:21361363.
            
            Summary: The protein encoded by this gene is a member of the
            BTG/Tob family. This family has structurally related proteins that
            appear to have antiproliferative properties. This encoded protein
            might play a role in neurogenesis in the central nervous system.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1-q21.2"
     gene            1..1378
                     /gene="BTG3"
                     /note="synonyms: ANA, TOB5, TOFA, TOB55, MGC8928"
                     /db_xref="GeneID:10950"
                     /db_xref="MIM:605674"
     CDS             154..912
                     /gene="BTG3"
                     /note="abundant in neuroepithelium area;
                     go_process: regulation of cell cycle [goid 0000074]
                     [evidence TAS] [pmid 9632145];
                     go_process: negative regulation of cell proliferation
                     [goid 0008285] [evidence TAS] [pmid 9632145]"
                     /codon_start=1
                     /product="B-cell translocation gene 3"
                     /protein_id="NP_006797.3"
                     /db_xref="GI:28872722"
                     /db_xref="GeneID:10950"
                     /db_xref="MIM:605674"
                     /translation="MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTLILQEKYKN
                     HWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVC
                     CRYGEKNNAFIVASFENKDENKDEISRKVTRALDKVTSDYHSGSSSSDEETSKEMEVK
                     PSSVTAAASPVYQISELIFPPLPMWHPLPRKKPGMYRGNGHQNHYPPPVPFGYPNQGR
                     KNKPYRPIPVTWVPPPGMHCDRNHWINPHMLAPH"
     polyA_signal    1329..1334
                     /gene="BTG3"
     polyA_site      1352
                     /gene="BTG3"
                     /evidence=experimental
ORIGIN      
        1 cgacgcggga gccgcacgcg ccggacgagg ctcgctgcgc tccctgttgc ccagcgcggg
       61 cccgttgagg cggagccctc agttcccggc caggacacgg tctgggccgc cgaatctccg
      121 gccgaagagc ggcggcggca gcggcggaaa aaaatgaaga atgaaattgc tgccgttgtc
      181 ttctttttca caaggctagt tcgaaaacat gataagttga aaaaagaggc agttgagagg
      241 tttgctgaga aattgaccct aatacttcaa gaaaaatata aaaatcactg gtatccagaa
      301 aaaccatcga aaggacaggc ctacagatgt attcgtgtca ataaatttca gagagttgat
      361 cctgatgtcc tgaaagcctg tgaaaacagc tgcatcttgt atagtgacct gggcttgcca
      421 aaggagctca ctctctgggt ggacccatgt gaggtgtgct gtcggtatgg agagaaaaac
      481 aatgcattca ttgttgccag ctttgaaaat aaagatgaga acaaggatga gatctccagg
      541 aaagttacca gggcccttga taaggttacc tctgattatc attcaggatc ctcttcttca
      601 gatgaagaaa caagtaagga aatggaagtg aaacccagtt cggtgactgc agccgcaagt
      661 cctgtgtacc agatttcaga acttatattt ccacctcttc caatgtggca ccctttgccc
      721 agaaaaaagc caggaatgta tcgagggaat ggccatcaga atcactatcc tcctcctgtt
      781 ccatttggtt atccaaatca gggaagaaaa aataaaccat atcgcccaat tccagtgaca
      841 tgggtacctc ctcctggaat gcattgtgac cggaatcact ggattaatcc tcacatgtta
      901 gcacctcact aacttcgttt ttgattgtgt tggtgtcatg ttgagaaaaa ggtagaataa
      961 accttactac acattaaaag ttaaaagttc ttactaatag tagtgaagtt agatgggcca
     1021 aaccatcaaa cttattttta tagaagttat tgagaataat ctttcttaaa aaatatatgc
     1081 actttagata ttgatatagt ttgagaaatt ttattaaagt tagtcaagtg cctaagtttt
     1141 taatattgga cttgagtatt tatatattgt gcatcaactc tgttggatac gagaacactg
     1201 tagaagtgga cgatttgttc tagcaccttt gagaatttac tttatggagc gtatgtaagt
     1261 tatttatata caaggaaatc tattttatgt cgttgtttaa gagaattgtg tgaaatcatg
     1321 tagttgcaaa taaaaaatag tttgaggcat gaaaaaaaaa aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_007044               1532 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens katanin p60 (ATPase-containing) subunit A 1 (KATNA1),
            mRNA.
ACCESSION   NM_007044
VERSION     NM_007044.2  GI:9951918
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   McNally,K.P., Bazirgan,O.A. and McNally,F.J.
  TITLE     Two domains of p80 katanin regulate microtubule severing and
            spindle pole targeting by p60 katanin
  JOURNAL   J. Cell. Sci. 113 (Pt 9), 1623-1633 (2000)
   PUBMED   10751153
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   McNally,F.J. and Thomas,S.
  TITLE     Katanin is responsible for the M-phase microtubule-severing
            activity in Xenopus eggs
  JOURNAL   Mol. Biol. Cell 9 (7), 1847-1861 (1998)
   PUBMED   9658175
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Hartman,J.J., Mahr,J., McNally,K., Okawa,K., Iwamatsu,A.,
            Thomas,S., Cheesman,S., Heuser,J., Vale,R.D. and McNally,F.J.
  TITLE     Katanin, a microtubule-severing protein, is a novel AAA ATPase that
            targets to the centrosome using a WD40-containing subunit
  JOURNAL   Cell 93 (2), 277-287 (1998)
   PUBMED   9568719
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   McNally,F.J., Okawa,K., Iwamatsu,A. and Vale,R.D.
  TITLE     Katanin, the microtubule-severing ATPase, is concentrated at
            centrosomes
  JOURNAL   J. Cell. Sci. 109 (Pt 3), 561-567 (1996)
   PUBMED   8907702
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   McNally,F.J. and Vale,R.D.
  TITLE     Identification of katanin, an ATPase that severs and disassembles
            stable microtubules
  JOURNAL   Cell 75 (3), 419-429 (1993)
   PUBMED   8221885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF056022.1.
            On Aug 30, 2000 this sequence version replaced gi:5901989.
            
            Summary: Microtubules, polymers of alpha and beta tubulin subunits,
            form the mitotic spindle of a dividing cell and help to organize
            membranous organelles during interphase. Katanin is a heterodimer
            that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa
            accessory protein (p80 subunit B 1). The p60 subunit acts to sever
            and disassemble microtubules, while the p80 subunit targets the
            enzyme to the centrosome. This gene encodes the p80 subunit. This
            protein is a member of the AAA family of ATPases.
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1532
                     /gene="KATNA1"
                     /db_xref="GeneID:11104"
                     /db_xref="MIM:606696"
     CDS             46..1521
                     /gene="KATNA1"
                     /note="go_component: cytoskeleton [goid 0005856] [evidence
                     TAS] [pmid 9658175];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: nucleotide binding [goid 0000166] [evidence
                     IEA];
                     go_process: mitosis [goid 0007067] [evidence TAS] [pmid
                     9658175]"
                     /codon_start=1
                     /product="katanin p60 subunit A 1"
                     /protein_id="NP_008975.1"
                     /db_xref="GI:5901990"
                     /db_xref="GeneID:11104"
                     /db_xref="MIM:606696"
                     /translation="MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVK
                     DTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPV
                     PVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQ
                     NKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAK
                     KLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSS
                     TLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELL
                     VQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLR
                     ISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSK
                     EEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC"
ORIGIN      
        1 taaagtgttt ctttttttct tcttcttttt agcttacagt tgaacatgag tcttcttatg
       61 attagtgaga atgtaaaatt ggctcgtgaa tatgcattgc tgggaaacta tgactctgcg
      121 atggtctatt atcagggagt tcttgaccaa atgaacaagt atctgtactc agtcaaagat
      181 acatacctcc agcagaaatg gcaacaggtt tggcaggaaa taaatgtgga agctaaacat
      241 gttaaagata tcatgaaaac actagagagc tttaaactgg acagcactcc cttgaaagcg
      301 gcacagcatg accttccagc ttctgaggga gaagtctggt ccatgcctgt acctgttgaa
      361 cgaagaccct caccaggacc tagaaaacgc caatcttctc agtacagtga ccctaaatca
      421 catggtaatc gtccaagtac aactgtcaga gttcaccgtt catctgcaca gaatgttcac
      481 aatgacagag ggaaagctgt tcgttgtcgt gaaaagaaag aacagaataa aggaagagag
      541 gaaaagaaca aatcacctgc tgcagtaaca gaaccagaga caaataaatt tgatagtacc
      601 ggatatgata aagacttagt agaagctttg gaaagagata taatttccca gaatcccaat
      661 gttcgatggg atgatatcgc tgatttagta gaagctaaaa agttgcttaa ggaagccgta
      721 gtgttaccaa tgtggatgcc cgaattcttt aagggcatta ggagaccatg gaaaggagta
      781 ctgatggtcg gcccacctgg cacggggaag acgctccttg ctaaagcagt agctacagaa
      841 tgcaagacaa cattcttcaa tgtctcttca tcaactttga cttccaaata cagaggagaa
      901 tctgagaagc ttgttcgtct tctgtttgaa atggctcgat tttattctcc agccaccata
      961 tttattgatg agatagactc catctgtagt cgccgaggga cttctgaaga acatgaagca
     1021 agcagaaggg tgaaagcgga gctgctggtt cagatggatg gtgttggagg tacttctgaa
     1081 aatgatgacc cttccaaaat ggttatggtt ctggcagcta ctaattttcc ctgggatata
     1141 gatgaggctt taagacgacg ccttgagaaa cgaatctata ttcctttgcc gtcagcaaaa
     1201 ggcagggagg agctattacg aataagtcta cgtgagttgg aattggctga tgatgttgac
     1261 cttgcaagta tagcagaaaa catggaaggt tattcaggtg cggacattac caacgtgtgc
     1321 agggatgcgt ccttgatggc aatgagaagg cgcattgaag gtttgactcc agaggaaatc
     1381 cgaaatcttt ccaaagaaga aatgcacatg cctacaacta tggaggattt cgagatggct
     1441 ttaaaaaagg tttctaagtc agtgtctgct gcagacattg aaagatacga gaaatggata
     1501 tttgagtttg gatcatgcta actcgagaag cc
//

LOCUS       NM_007236               3248 bp    mRNA    linear   PRI 29-NOV-2004
DEFINITION  Homo sapiens calcium binding protein P22 (CHP), mRNA.
ACCESSION   NM_007236
VERSION     NM_007236.3  GI:37622888
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Pang,T., Hisamitsu,T., Mori,H., Shigekawa,M. and Wakabayashi,S.
  TITLE     Role of calcineurin B homologous protein in pH regulation by the
            Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural
            elements
  JOURNAL   Biochemistry 43 (12), 3628-3636 (2004)
   PUBMED   15035633
  REMARK    GeneRIF: CHP is important for pH(i)-dependent regulation of Na+/H+
            exchanger 1 (NHE1) via tightly bound Ca2+ ions which serve as a
            crucial structural elements required for this role.
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Pang,T., Wakabayashi,S. and Shigekawa,M.
  TITLE     Expression of calcineurin B homologous protein 2 protects serum
            deprivation-induced cell death by serum-independent activation of
            Na+/H+ exchanger
  JOURNAL   J. Biol. Chem. 277 (46), 43771-43777 (2002)
  MEDLINE   22313590
   PUBMED   12226101
  REMARK    GeneRIF: serum-independent activation of NHE1 by bound CHP2 is one
            of the key mechanisms for the maintenance of high pH(i) and the
            resistance to serum deprivation-induced cell death in malignantly
            transformed cells
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Pang,T., Su,X., Wakabayashi,S. and Shigekawa,M.
  TITLE     Calcineurin homologous protein as an essential cofactor for Na+/H+
            exchangers
  JOURNAL   J. Biol. Chem. 276 (20), 17367-17372 (2001)
  MEDLINE   21248790
   PUBMED   11350981
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Lin,X., Sikkink,R.A., Rusnak,F. and Barber,D.L.
  TITLE     Inhibition of calcineurin phosphatase activity by a calcineurin B
            homologous protein
  JOURNAL   J. Biol. Chem. 274 (51), 36125-36131 (1999)
  MEDLINE   20062818
   PUBMED   10593895
REFERENCE   5  (bases 1 to 3248)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (22), 12631-12636 (1996)
  MEDLINE   97057295
   PUBMED   8901634
REFERENCE   6  (bases 1 to 3248)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
  MEDLINE   95130111
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U61538.1, AV761136.2,
            BG398684.1, BM828547.1, BC051815.1, BQ213482.1, BX391712.2,
            BC008373.1, BE250654.1 and BI491312.1.
            On Oct 10, 2003 this sequence version replaced gi:21536282.
            
            Summary: The protein encoded by this gene is a phosphoprotein that
            binds to the sodium-potassium exchangers (NHEs). This protein
            serves as an essential cofactor which supports the physiological
            activity of NHE family members. It has protein sequence similarity
            to calcineurin B and it is also known to be an endogenous inhibitor
            of calcineurin activity.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..3248
                     /gene="CHP"
                     /note="synonym: SLC9A1BP"
                     /db_xref="GeneID:11261"
                     /db_xref="MIM:606988"
     CDS             145..732
                     /gene="CHP"
                     /note="SLC9A1 binding protein; calcineurin homologous
                     protein; calcineurin B homolog;
                     go_function: calcium ion binding [goid 0005509] [evidence
                     IEA];
                     go_function: potassium channel regulator activity [goid
                     0015459] [evidence TAS] [pmid 8901634];
                     go_process: potassium ion transport [goid 0006813]
                     [evidence TAS] [pmid 8901634];
                     go_process: small GTPase mediated signal transduction
                     [goid 0007264] [evidence TAS] [pmid 8901634]"
                     /codon_start=1
                     /product="calcium binding protein P22"
                     /protein_id="NP_009167.1"
                     /db_xref="GI:6005731"
                     /db_xref="GeneID:11261"
                     /db_xref="MIM:606988"
                     /translation="MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENG
                     TLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDV
                     NGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTI
                     QEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH"
     polyA_signal    3205..3210
                     /gene="CHP"
     polyA_site      3230
                     /gene="CHP"
                     /evidence=experimental
ORIGIN      
        1 accacccctg ggttccctcc cgggtccgca gtggaaacac tgccctctcc cttcttgacc
       61 cctagccctt ccttccctcc ctccttccct cctgtcgccg tctcttctgg cgccgctgct
      121 cccggaggag ctcccggcac ggcgatgggt tctcgggcct ccacgttact gcgggacgaa
      181 gagctcgagg agatcaagaa ggagaccggc ttttcccaca gtcaaatcac tcgcctctac
      241 agccggttca ccagcctgga caaaggagag aatgggactc tcagccggga agatttccag
      301 aggattccag aacttgccat caacccactg ggggaccgga tcatcaatgc cttctttcca
      361 gagggagagg accaggtaaa cttccgtgga ttcatgcgaa ctttggctca tttccgcccc
      421 attgaggata atgaaaagag caaagatgtg aatggacccg aaccactcaa cagccgaagc
      481 aacaaactgc actttgcttt tcgactatat gatttggata aagatgaaaa gatctcccgt
      541 gatgagctgt tacaggtgct acgcatgatg gtcggagtaa atatctcaga tgagcagctg
      601 ggcagcatcg cagacaggac cattcaggag gctgatcagg atggggacag tgccatatct
      661 ttcacagaat ttgttaaggt tttggagaag gtggatgtag aacagaaaat gagcatccga
      721 tttcttcact aaaggagacc aaactgttcc ttgcggtcta gtatttaaga actggaactt
      781 gaaagtcctc cttctaccaa ctccacctcc accccctcat tccccttctc ccaaagtact
      841 actgctgttg catgacaacc ccaaatatgt tctgtcaaca caaacctgcc tttggtgtat
      901 aaacagggca ttacagaatg gtacacccta tatatttctg ttcagtatcc attcactagt
      961 tcttcattta taaatatcat cttccccatt ctgctgctga atgccacaca tccatccagt
     1021 ctgagaaagt gagagaggca atcatgccaa gaacaagcca gcaaagctct ttcaccagat
     1081 gtagactgta gccctgctgc cttccctcca gcgagtctgc cagcatgctt cttcatcctt
     1141 tttatatgtt ctttgcttcc tacttccctg tcttccaaca tactgttcac ttactctggc
     1201 agtctttctg cttttcatta agcctcaaaa tctcctctgt tctacttggc accacaagct
     1261 atgtcctata tatgtatttc tgacttggca ggatagttca ggggtctggc agtttttatt
     1321 taccttcatt attaaatggg cctctgggat gttgcctctt caggagcttt ttggtaatca
     1381 atacttctct cagaagtatg agaccatcct ctgcactctg ctctgtcatc aaaggctgct
     1441 gggtggagat accctttttg aaaggtggcc ttggtgagag gtatggagcc aagtcttcta
     1501 ggttgcttgc ccacatcact ctatctctgg cctctgattc tcaactttgt acctgtgtgg
     1561 ctcctcttgt tagtgcaatg ttgactgttg aaaaagcagc agtatgctta caggtttgct
     1621 tagtttgggg acaccgttac caccagaatg gctgctctga caatatgcct agggactttc
     1681 tcatggcttt tatttaataa ggaggctggg caccctataa agcctcatgc attcacacct
     1741 ttgcagcatg gtttatgcct cagtgttatg tgcactggaa tgttttccac ttcacatttc
     1801 caagtagaaa tattagtgtt acggaagtgc ctaatatccc agtccaaatt tttttttttt
     1861 tttttttttt tttttgagac agagtcttgc tctgtcaccc aggctggagt gcagtggtgc
     1921 gatcgctcac tgcaacctca gcctcctgga tttaagtgat tctcctgcct cagcctccca
     1981 agtagctggg attacaggtg tgcaccacca tgcccggcta attttttgta tttttagtgg
     2041 agacagggtt tcaccatgtt ggccaggctg gtctcgaact cctgacctcg tgatccgcct
     2101 gcctcagcct cccaaagtgc tgggattaca ggtgtgagcc accacgcctg gccccagtcc
     2161 aaaatattta aagattgttt ccttagtgtc ttgaagtttt gcacaaaatt cttttttttg
     2221 agatggagtc tcactctgtc acccaggctg gagtgcagtg gcgtgatctt ggctcactgc
     2281 aacctctgcc tcctgggttc aagcaattct cccacctcag cctcccaagt agctgggatt
     2341 acagacgtgt gccaccatac ctgggtaatt tttgcatttt tagtggagag ggagtttcac
     2401 catgttggcc aggttggtct tgaactcctg acctcaggtg atcctcctgc ctcggcctcc
     2461 caaagtgctg ggattacagg catgagccac cgtgctcagc cgcaaaattc tttatgaatt
     2521 ttacacttgg caaatgttaa tgacggaagc catagtctgc tcctaataca tgtccaaagc
     2581 attgactgtt gtgtcattag ctgcctggtt acattagctc cctggcttct tgtttagacc
     2641 actgctaatc ccttaaaaac aagaggtctg gcactagtag cacaacctaa ggtggcatta
     2701 cagatctttg agcgagccac agcaactttt ctgccaagtc agcttagttt agacttcagt
     2761 gaatcaggct attgctatcc taatgtatgt ctctatgagt gtatttagcc acacatctgc
     2821 ccttggttga ctttctgact cattgcttgc ttgcttgttt ccttgctttg gaaaactatt
     2881 gaagattgct aaaaaatacc actgcaaagt gatggaaaag ggtggagaac aggggagtag
     2941 ccaggctgga tggctcaaat ataaatgaat gaggaattct ttatgaagta tcagtcagat
     3001 tttatgatta agtgatgtaa tataggaatt atgtaaaagg gaagaatgtc tgatactgat
     3061 ctattagaga ggtactttag aggcttcttg attggcataa agttcctaag gttatagatt
     3121 ttcccccctt ttggctgtat agcaaagtgt tttaatccac ggttgtgcct tattgttcca
     3181 ttaaaattgt atcttcgatc catcaataaa tacttgtggt tgaaacaaaa aaaaaaaaaa
     3241 aaaaaaaa
//

LOCUS       NM_012101               3018 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens tripartite motif-containing 29 (TRIM29), transcript
            variant 1, mRNA.
ACCESSION   NM_012101
VERSION     NM_012101.2  GI:17402908
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J. 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Tauchi,H., Green,C., Knapp,M., Laderoute,K. and Kapp,L.
  TITLE     Altered splicing of the ATDC message in ataxia telangiectasia group
            D cells results in the absence of a functional protein
  JOURNAL   Mutagenesis 15 (2), 105-108 (2000)
   PUBMED   10719033
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Laderoute,K.R., Knapp,A.M., Green,C.J., Sutherland,R.M. and
            Kapp,L.N.
  TITLE     Expression of the ATDC (ataxia telangiectasia group
            D-complementing) gene in A431 human squamous carcinoma cells
  JOURNAL   Int. J. Cancer 66 (6), 772-778 (1996)
   PUBMED   8647648
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Brzoska,P.M., Chen,H., Zhu,Y., Levin,N.A., Disatnik,M.H.,
            Mochly-Rosen,D., Murnane,J.P. and Christman,M.F.
  TITLE     The product of the ataxia-telangiectasia group D complementing
            gene, ATDC, interacts with a protein kinase C substrate and
            inhibitor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7824-7828 (1995)
   PUBMED   7644499
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Murnane,J.P., Zhu,Y., Young,B.R. and Christman,M.F.
  TITLE     Expression of the candidate A-T gene ATDC is not detectable in a
            human cell line with a normal response to ionizing radiation
  JOURNAL   Int. J. Radiat. Biol. 66 (6 Suppl), S77-S84 (1994)
   PUBMED   7836856
REFERENCE   6  (bases 1 to 3018)
  AUTHORS   Hosoi,Y. and Kapp,L.N.
  TITLE     Expression of a candidate ataxia-telangiectasia group D gene in
            cultured fibroblast cell lines and human tissues
  JOURNAL   Int. J. Radiat. Biol. 66 (6 Suppl), S71-S76 (1994)
   PUBMED   7530755
REFERENCE   7  (bases 1 to 3018)
  AUTHORS   Leonhardt,E.A., Kapp,L.N., Young,B.R. and Murnane,J.P.
  TITLE     Nucleotide sequence analysis of a candidate gene for
            ataxia-telangiectasia group D (ATDC)
  JOURNAL   Genomics 19 (1), 130-136 (1994)
   PUBMED   8188213
REFERENCE   8  (bases 1 to 3018)
  AUTHORS   Richard,C.W. III, Cox,D.R., Kapp,L., Murnane,J., Cornelis,F.,
            Julier,C., Lathrop,G.M. and James,M.R.
  TITLE     A radiation hybrid map of human chromosome 11q22-q23 containing the
            ataxia-telangiectasia disease locus
  JOURNAL   Genomics 17 (1), 1-5 (1993)
   PUBMED   8406440
REFERENCE   9  (bases 1 to 3018)
  AUTHORS   Kapp,L.N., Painter,R.B., Yu,L.C., van Loon,N., Richard,C.W. III,
            James,M.R., Cox,D.R. and Murnane,J.P.
  TITLE     Cloning of a candidate gene for ataxia-telangiectasia group D
  JOURNAL   Am. J. Hum. Genet. 51 (1), 45-54 (1992)
   PUBMED   1609804
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L24203.1.
            On Dec 7, 2001 this sequence version replaced gi:6912249.
            
            Summary: The protein encoded by this gene belongs to the TRIM
            protein family. It has multiple zinc finger motifs and a leucine
            zipper motif. It has been proposed to form homo- or heterodimers
            which are involved in nucleic acid binding. Thus, it may act as a
            transcriptional regulatory factor involved in carcinogenesis and/or
            differentiation. It may also function in the suppression of
            radiosensitivity since it is associated with ataxia telangiectasia
            phenotype. Multiple alternatively spliced transcript variants have
            been detected for this gene but the full-length nature of all of
            them has not been described yet. One of the transcripts of 2.4 kb,
            appears to be untranslated and probably nonfunctional.
            
            Transcript Variant: This variant (1) encodes the full-length
            isoform (alpha).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22-q23"
     gene            1..3018
                     /gene="TRIM29"
                     /note="synonym: ATDC"
                     /db_xref="GeneID:23650"
     CDS             125..1891
                     /gene="TRIM29"
                     /note="isoform alpha is encoded by transcript variant 1;
                     tripartite motif protein TRIM29; ataxia-telangiectasia
                     group D-associated protein;
                     go_component: intracellular [goid 0005622] [evidence IEA];
                     go_function: zinc ion binding [goid 0008270] [evidence
                     IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 8188213];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence TAS] [pmid 8188213]"
                     /codon_start=1
                     /product="tripartite motif protein TRIM29 isoform alpha"
                     /protein_id="NP_036233.2"
                     /db_xref="GI:17402909"
                     /db_xref="GeneID:23650"
                     /translation="MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTN
                     GHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGK
                     RSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGL
                     FSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIR
                     DFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKE
                     QLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQ
                     REQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPP
                     LPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRY
                     VNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSSPGRFTKETTQKNFNNLYGT
                     KGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQSPKAQPQTWKSGKQT
                     MLSHYRPFYVNKGNGIGSNEAP"
     polyA_signal    3000..3005
                     /gene="TRIM29"
     polyA_site      3018
                     /gene="TRIM29"
                     /evidence=experimental
ORIGIN      
        1 ctcctcacag gtgtgtctct agtcctcgtg gttgcctgcc ccactccctg ccgagacgcc
       61 tgccagaaag gtcacctatc ctgaacccca gcaagcctga aacagctcag ccaagcaccc
      121 tgcgatggaa gctgcagatg cctccaggag caacgggtcg agcccagaag ccagggatgc
      181 ccggagcccg tcgggcccca gtggcagcct ggagaatggc accaaggctg acggcaagga
      241 tgccaagacc accaacgggc acggcgggga ggcagctgag ggcaagagcc tgggcagcgc
      301 cctgaagcca ggggaaggta ggagcgccct gttcgcgggc aatgagtggc ggcgacccat
      361 catccagttt gtcgagtccg gggacgacaa gaactccaac tacttcagca tggactctat
      421 ggaaggcaag aggtcgccgt acgcagggct ccagctgggg gctgccaaga agccacccgt
      481 tacctttgcc gaaaagggcg agctgcgcaa gtccattttc tcggagtccc ggaagcccac
      541 ggtgtccatc atggagcccg gggagacccg gcggaacagc tacccccggg ccgacacggg
      601 ccttttttca cggtccaagt ccggctccga ggaggtgctg tgcgactcct gcatcggcaa
      661 caagcagaag gcggtcaagt cctgcctggt gtgccaggcc tccttctgcg agctgcatct
      721 caagccccac ctggagggcg ccgccttccg agaccaccag ctgctcgagc ccatccggga
      781 ctttgaggcc cgcaagtgtc ccgtgcatgg caagacgatg gagctcttct gccagaccga
      841 ccagacctgc atctgctacc tttgcatgtt ccaggagcac aagaatcata gcaccgtgac
      901 agtggaggag gccaaggccg agaaggagac ggagctgtca ctgcaaaagg agcagctgca
      961 gctcaagatc attgagattg aggatgaagc tgagaagtgg cagaaggaga aggaccgcat
     1021 caagagcttc accaccaatg agaaggccat cctggagcag aacttccggg acctggtgcg
     1081 ggacctggag aagcaaaagg aggaagtgag ggctgcgctg gagcagcggg agcaggatgc
     1141 tgtggaccaa gtgaaggtga tcatggatgc tctggatgag agagccaagg tgctgcatga
     1201 ggacaagcag acccgggagc agctgcatag catcagcgac tctgtgttgt ttctgcagga
     1261 atttggtgca ttgatgagca attactctct ccccccaccc ctgcccacct atcatgtcct
     1321 gctggagggg gagggcctgg gacagtcact aggcaacttc aaggacgacc tgctcaatgt
     1381 atgcatgcgc cacgttgaga agatgtgcaa ggcggacctg agccgtaact tcattgagag
     1441 gaaccacatg gagaacggtg gtgaccatcg ctatgtgaac aactacacga acagcttcgg
     1501 gggtgagtgg agtgcaccgg acaccatgaa gagatactcc atgtacctga cacccaaagg
     1561 tggggtccgg acatcatacc agccctcgtc tcctggccgc ttcaccaagg agaccaccca
     1621 gaagaatttc aacaatctct atggcaccaa aggtaactac acctcccggg tctgggagta
     1681 ctcctccagc attcagaact ctgacaatga cctgcccgtc gtccaaggca gctcctcctt
     1741 ctccctgaaa ggctatccct ccctcatgcg gagccaaagc cccaaggccc agccccagac
     1801 ttggaaatct ggcaagcaga ctatgctgtc tcactaccgg ccattctacg tcaacaaagg
     1861 caacgggatt gggtccaacg aagccccatg agctcctggc ggaaggaacg aggcgccaca
     1921 cccctgctct tcctcctgac cctgctgctc ttgccttcta agctactgtg cttgtctggg
     1981 tgggagggag cctggtcctg cacctgccct ctgcagccct ctgccagcct cttgggggca
     2041 gttccggcct ctccgacttc cccactggcc acactccatt cagactcctt tcctgccttg
     2101 tgacctcaga tggtcaccat cattcctgtg ctcagaggcc aacccatcac aggggtgaga
     2161 taggttgggg cctgccctaa cccgccagcc tcctcctctc gggctggatc tgggggctag
     2221 cagtgagtac ccgcatggta tcagcctgcc tctcccgccc acgccctgct gtctccaggc
     2281 ctatagacgt ttctctccaa ggccctatcc cccaatgttg tcagcagatg cctggacagc
     2341 acagccaccc atctcccatt cacatggccc acctcctgct tcccagagga ctggccctac
     2401 gtgctctctc tcgtcctacc tatcaatgcc cagcatggca gaacctgcag cccttggcca
     2461 ctgcagatgg aaacctctca gtgtcttgac atcaccctac ccaggcggtg ggtctccacc
     2521 acagccactt tgagtctgtg gtccctggag ggtggcttct cctgactggc aggatgacct
     2581 tagccaagat attcctctgt tccctctgct gagataaaga attcccttaa catgatataa
     2641 tccacccatg caaatagcta ctggcccagc taccatttac catttgccta cagaatttca
     2701 ttcagtctac actttggcat tctctctggc gatggagtgt ggctgggctg accgcaaaag
     2761 gtgccttaca cactgccccc accctcagcc gttgccccat cagaggctgc ctcctccttc
     2821 tgattacccc ccatgttgca tatcagggtg ctcaaggatt ggagaggaga caaaaccagg
     2881 agcagcacag tggggacatc tcccgtctca acagccccag gcctatgggg gctctggaag
     2941 gatgggccag cttgcagggg ttggggaggg agacatccag cttgggcttt cccctttgga
     3001 ataaaccatt ggtctgtc
//

LOCUS       NM_012388               3959 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens pallidin homolog (mouse) (PLDN), mRNA.
ACCESSION   NM_012388
VERSION     NM_012388.2  GI:38505202
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3959)
  AUTHORS   Ciciotte,S.L., Gwynn,B., Moriyama,K., Huizing,M., Gahl,W.A.,
            Bonifacino,J.S. and Peters,L.L.
  TITLE     Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a
            novel protein that is part of the pallidin-muted complex (BLOC-1)
  JOURNAL   Blood 101 (11), 4402-4407 (2003)
   PUBMED   12576321
  REMARK    GeneRIF: no defects in the known components of pallidin-muted
            complex (BLOC-1)have been identified in 142 patients with HPS,
            suggesting that BLOC-1 function may be critical in humans.
REFERENCE   2  (bases 1 to 3959)
  AUTHORS   Huang,L., Kuo,Y.M. and Gitschier,J.
  TITLE     The pallid gene encodes a novel, syntaxin 13-interacting protein
            involved in platelet storage pool deficiency
  JOURNAL   Nat. Genet. 23 (3), 329-332 (1999)
   PUBMED   10610180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK128626.1, AF080470.1,
            BC026289.1 and AF131859.1.
            On Nov 25, 2003 this sequence version replaced gi:6912573.
            
            Summary: The protein encoded by this gene may play a role in
            intracellular vesicle trafficking. It interacts with Syntaxin 13
            which mediates intracellular membrane fusion. Several alternatively
            spliced transcript variants of this gene have been described, but
            the full-length nature of some of these variants has not been
            determined.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..3959
                     /gene="PLDN"
                     /note="synonyms: PA, PALLID"
                     /db_xref="GeneID:26258"
                     /db_xref="MIM:604310"
     CDS             226..744
                     /gene="PLDN"
                     /note="pallid (mouse) homolog, pallidin; syntaxin
                     13-interacting protein pallid; syntaxin 13 binding protein
                     1;
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_function: syntaxin-13 binding [goid 0030349] [evidence
                     TAS] [pmid 10610180];
                     go_process: synaptic vesicle docking during exocytosis
                     [goid 0016081] [evidence NAS] [pmid 10610180]"
                     /codon_start=1
                     /product="pallidin"
                     /protein_id="NP_036520.1"
                     /db_xref="GI:6912574"
                     /db_xref="GeneID:26258"
                     /db_xref="MIM:604310"
                     /translation="MSVPGPSSPDGALTRPPYCLEAGEPTPGLSDTSPDEGLIEDLTI
                     EDKAVEQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDIN
                     ALFAEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFER
                     EKQLTARPAKRM"
     polyA_signal    3919..3924
                     /gene="PLDN"
     polyA_site      3941
                     /gene="PLDN"
                     /evidence=experimental
ORIGIN      
        1 acactgcgtc cggggccaga cgacgatatc agcgcggggt ccccacaacg ccatggggca
       61 gagccaactc tcgagcgcgt gatcgaagcc cgcagttttt tcgcccccgt cacttccggg
      121 tgcgacaatc tcttctgtcc ggccagccgc tggagtcgtt aggtgccgcc ttgcttctga
      181 cgagccacac gtttgcttct tccctgtgtt cccagctgga gggacatgag tgtccctggg
      241 ccgtcgtctc cggacggggc cctgacacgg ccaccctact gcctggaggc cggggagccg
      301 acgcctggtt taagtgacac ttctccagat gaagggttaa tagaggactt gactatagaa
      361 gacaaagcag tggagcaact ggcagaagga ttgctttctc attatttgcc agatctgcag
      421 agatcaaaac aagccctcca ggaactcaca cagaaccaag ttgtattgtt agacacactg
      481 gaacaagaga tttcaaaatt taaagaatgt cattctatgt tggatattaa tgctttgttt
      541 gctgaggcta aacactatca tgccaagttg gtgaatataa gaaaagagat gctgatgctt
      601 catgaaaaaa catcaaagtt aaaaaaaaga gcacttaaac tgcagcagaa gaggcaaaaa
      661 gaagagttgg aaagggagca gcaacgagag aaggagtttg aaagagaaaa gcagttaact
      721 gccagaccag ccaaaaggat gtgaaaagtt gtgtttgtgt gttttcttct cctgtcccat
      781 atttgggtta tgatgactca agtgtagact gaagttgagg tagtgcctta tgccattatg
      841 tcatatgttg aaatccttat tccggtatta ctgtgtctcc atgccttttt tccaagtagc
      901 agacgtcatg ttgcatggtt tttgatattt atatgtaagt ttttcaaatt ttgcttaatt
      961 ttaaaattta ttattttgat cttgaattat ttataaactg gaaagtggtt tgattattgt
     1021 gagtcaaaac tctaagtggt taaaaattag tatgaatttt ttagcttctt aatgaatatg
     1081 gatttaaaac tctccagttc ttattttatg aaatgacttg cctttctggt aatacaatgc
     1141 tgatttttta gtaattgcct tttcattact ttgttaagaa gaaatgccag ctgtttaatc
     1201 acacctaccc ctggaaaaga ggtaaacctt ttgaacagtt gaatttcatc agaagctcta
     1261 tagctttttg gtgagaggaa gtgatactct ttattacaag aaacaaggaa ttaacaaaaa
     1321 taaggaactt gttgctacct ttcttttctg ttgaacatta aaaataattt ggtttgtgga
     1381 ctgggcatgg tggcttatgg aaaagaggtg agcctttgtg aagaacataa tggaaaagtg
     1441 catgtacggg aaataacagc actttaggtg tagttcaggt gagcaagatg ccagatagtt
     1501 tctactaacc atatactctt tctgcttctt agcgtcgttg tcactgcttc tgtggctttt
     1561 gggttcaaag tagattatat atattcctaa agcttggtgg aggtagtgga gctatcacac
     1621 actcaaatga gcttgtatat ttataataca atatagtatt atagtaacag ttatcataca
     1681 ctgagatata gtttctgtgc ttgtaaaaaa ttcttgaagt gaggccgggt gcggtggctc
     1741 atgcctgtaa tcccaacgct ttgggacgcc gaggcgggtg gatcatgagg tcaaaagatt
     1801 gagaccatcc tggccaacat ggtgaaaccc cgtctctact agaaatacaa aaattagctg
     1861 ggtgtggggg cgtgcgcctg tagtcccagc tacttgggag gctgaggcag gagaattgct
     1921 tgaacccagg aggcagaggt tgcagtaagc caagatcgtg ccactgcact ccagccttgg
     1981 tgacagagca agactccgtc tccaaaaaaa agaaaaaaaa atttcttgaa gtggaatgat
     2041 gtacaccaaa tacccacttt atagataatt acagggatgg tgaaaaatta gtaaatagct
     2101 tcacaaaaga ggcagcgtga tacctttagt gttttctaga atttttttct ggatattata
     2161 tgtaagaatt tattgtttga gggaaatacg aggtttcatt gtttaaaatc aagagtgtat
     2221 tgtttactgt tttacagtat tatttaatat ccaactggtc tccaatctcc attacatagg
     2281 gactgtacag agcctgtgaa gatgtatgaa tggtatcttt tataatccac aatacatttc
     2341 tggtaagatg gaatcactac ctctgatcac atatcaggct aacgatagag aaagcattag
     2401 gtttaagttg agggctaaga actggtttgt ttaaaggttt aaattgttgg aaaagagcat
     2461 ttgccttctt taatgaatga tggtctcaca attcagttga ctttgaccta atatttaaga
     2521 atataaatat attttatttg aaaggctgag tgttgccctc aaacacttgc taaaactgcc
     2581 tagggcagga ttcattaggg cttgcagaca atgtcaccta aattgctgaa tgtactcatt
     2641 ataatatgat atctgacaaa ggtagtacag cgtttctgag tcatttggga ccaactgcag
     2701 tggttgttta aaatgctggt tcctgcacac aattctctat ctactgaagc acatctgttt
     2761 tctttgtttg ttttgctttg ctttttgttt ttaaagtttc ccccagtgat tccagtgcac
     2821 ctgaaaagtt gagaaccaca ggcttagtgg tacgttgggg tttcccacgc taggctgcat
     2881 agcattataa cctgggaacg ttaaaaaaaa tacagacatt cttgattctt agtgtagtta
     2941 tgatgtggat cctacgtatt ttttaaaaaa ctctccagat aattttgatg tcacgagtca
     3001 ctagtataga ctatctatct agtgagttgt attataagcg atgaaatact ttaaaagcta
     3061 cccagtaact cttgggatta attttatgaa ataaattctg agctgctgct tttgatatag
     3121 tcagacttaa gactgaaccc cagtagacag gcaatagata tagaattctg gttagctaat
     3181 tgaacttttg tgacctgttt aaaaacaaat caaatttatt gaacaaatga caaggcacaa
     3241 atactttcag aattgtattt cagttttgaa gatttaaaaa aaatgtgaaa ataaatatat
     3301 attagtatcc tttattttaa agtcaattgt aaaccagaag tactgttatt ttggtgatta
     3361 aaatccaaaa ctttagctgt atttcagtaa caaaaacata ccttactaga ctgtgatggc
     3421 tcacacctgt aatcccagtg ctttgggagg ctgaggtggg aagattcttt gagcccagga
     3481 gttcaaggct gcagtgaatt ctgatcgcac cactgaactc cagcccgtat gacagagtga
     3541 gaccctgttt ctaaaaacaa aacaaacaaa caaacaaaca acgtatctta ctgactaaac
     3601 tggaatggaa atcttataat tagtgttgta tttttctgca aaatagtgaa ttggtacttg
     3661 ggagacttct gttctttgtt gaaaaaaatt gcctttgttt tgaaattata tcacctgtgt
     3721 tctgaactaa aatgatggga gttcattttg tatttacttt gcagtaagta tcatgtaaat
     3781 atgcaaatgt tgaatgtaat atagattgtg tcctcattga gtttttgggt gatacagttt
     3841 ataaatataa caattataca ccctcataca ttcgtctgat tttgagcttg taagatgaga
     3901 actgcttttt acacatttaa taaaaaaagg tctctgaatt aaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_012434               3292 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens solute carrier family 17 (anion/sugar transporter),
            member 5 (SLC17A5), mRNA.
ACCESSION   NM_012434
VERSION     NM_012434.3  GI:34222139
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3292)
  AUTHORS   Landau,D., Cohen,D., Shalev,H., Pinsk,V., Yerushalmi,B., Zeigler,M.
            and Birk,O.S.
  TITLE     A novel mutation in the SLC17A5 gene causing both severe and mild
            phenotypes of free sialic acid storage disease in one inbred
            Bedouin kindred
  JOURNAL   Mol. Genet. Metab. 82 (2), 167-172 (2004)
   PUBMED   15172005
  REMARK    GeneRIF: Molecular studies showed that all four affected
            individuals were homozygous for the same novel 983G > A mutation in
            exon 8 of the SLC17A5 gene, replacing glycine with glutamic acid at
            position 328 of the sialin protein
REFERENCE   2  (bases 1 to 3292)
  AUTHORS   Aula,N., Kopra,O., Jalanko,A. and Peltonen,L.
  TITLE     Sialin expression in the CNS implicates extralysosomal function in
            neurons
  JOURNAL   Neurobiol. Dis. 15 (2), 251-261 (2004)
   PUBMED   15006695
  REMARK    GeneRIF: In primary neuronal cultures sialin was not targeted into
            lysosomes but rather revealed a punctate staining along the
            neuronal processes and was also seen in the plasma membrane.
REFERENCE   3  (bases 1 to 3292)
  AUTHORS   Aula,N., Jalanko,A., Aula,P. and Peltonen,L.
  TITLE     Unraveling the molecular pathogenesis of free sialic acid storage
            disorders: altered targeting of mutant sialin
  JOURNAL   Mol. Genet. Metab. 77 (1-2), 99-107 (2002)
  MEDLINE   22247160
   PUBMED   12359136
  REMARK    GeneRIF: expression, localization, and targeting of the wild-type
            sialin, as well as two mutant polypeptides in sialic acid storage
            disorders
REFERENCE   4  (bases 1 to 3292)
  AUTHORS   Verheijen,F.W., Verbeek,E., Aula,N., Beerens,C.E., Havelaar,A.C.,
            Joosse,M., Peltonen,L., Aula,P., Galjaard,H., van der Spek,P.J. and
            Mancini,G.M.
  TITLE     A new gene, encoding an anion transporter, is mutated in sialic
            acid storage diseases
  JOURNAL   Nat. Genet. 23 (4), 462-465 (1999)
  MEDLINE   20047778
   PUBMED   10581036
REFERENCE   5  (bases 1 to 3292)
  AUTHORS   Haataja,L., Schleutker,J., Laine,A.P., Renlund,M., Savontaus,M.L.,
            Dib,C., Weissenbach,J., Peltonen,L. and Aula,P.
  TITLE     The genetic locus for free sialic acid storage disease maps to the
            long arm of chromosome 6
  JOURNAL   Am. J. Hum. Genet. 54 (6), 1042-1049 (1994)
  MEDLINE   94256492
   PUBMED   8198127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC020961.2.
            On Aug 26, 2003 this sequence version replaced gi:21314648.
FEATURES             Location/Qualifiers
     source          1..3292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14-q15"
     gene            1..3292
                     /gene="SLC17A5"
                     /note="synonyms: SD, AST, NSD, SLD, ISSD, SIASD, SIALIN"
                     /db_xref="GeneID:26503"
                     /db_xref="MIM:604322"
     CDS             88..1575
                     /gene="SLC17A5"
                     /note="solute carrier family 17, member 5; sialic acid
                     storage disease;
                     go_component: lysosome [goid 0005764] [evidence IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: symporter activity [goid 0015293] [evidence
                     IEA];
                     go_function: transporter activity [goid 0005215] [evidence
                     IEA];
                     go_process: transport [goid 0006810] [evidence IEA]"
                     /codon_start=1
                     /product="solute carrier family 17 (anion/sugar
                     transporter), member 5"
                     /protein_id="NP_036566.1"
                     /db_xref="GI:6912666"
                     /db_xref="GeneID:26503"
                     /db_xref="MIM:604322"
                     /translation="MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAI
                     LAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQ
                     WDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLG
                     VGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSG
                     IICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSS
                     QKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLP
                     YLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLA
                     VAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPD
                     NTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH"
ORIGIN      
        1 ccggccgctc ggcccggggg cttcgggctg tcgggccggc gctcccttct ctgccaggtg
       61 gcgagtacac ctgctcacgt aggcgtcatg aggtctccgg ttcgagacct ggcccggaac
      121 gatggcgagg agagcacgga ccgcacgcct cttctaccgg gcgccccacg ggccgaagcc
      181 gctccagtgt gctgctctgc tcgttacaac ttagcaattt tggccttttt tggtttcttc
      241 attgtgtatg cattacgtgt gaatctgagt gttgcgttag tggatatggt agattcaaat
      301 acaactttag aagataatag aacttccaag gcatgtccag agcattctgc tcccataaaa
      361 gttcatcata atcaaacggg taagaagtac caatgggatg cagaaactca aggatggatt
      421 ctcggttcct ttttttatgg ctacatcatc acacagattc ctggaggata tgttgccagc
      481 aaaatagggg ggaaaatgct gctaggattt gggatccttg gcactgctgt cctcaccctg
      541 ttcactccca ttgctgcaga tttaggagtt ggaccactca ttgtactcag agcactagaa
      601 ggactaggag agggtgttac atttccagcc atgcatgcca tgtggtcttc ttgggctccc
      661 cctcttgaaa gaagcaaact tcttagcatt tcatatgcag gagcacagct tgggacagta
      721 atttctcttc ctctttctgg aataatttgc tactatatga attggactta tgtcttctac
      781 ttttttggta ctattggaat attttggttt cttttgtgga tctggttagt tagtgacaca
      841 ccacaaaaac acaagagaat ttcccattat gaaaaggaat acattctttc atcattaaga
      901 aatcagcttt cttcacagaa gtcagtgccg tgggtaccca ttttaaaatc cctgccactt
      961 tgggctatcg tagttgcaca cttttcttac aactggactt tttatacttt attgacatta
     1021 ttgcctactt atatgaagga gatcctaagg ttcaatgttc aagagaatgg gtttttatct
     1081 tcattgcctt atttaggctc ttggttatgt atgatcctgt ctggtcaagc tgctgacaat
     1141 ttaagggcaa aatggaattt ttcaacttta tgtgttcgca gaatttttag ccttatagga
     1201 atgattggac ctgcagtatt cctggtagct gctggcttca ttggctgtga ttattctttg
     1261 gccgttgctt tcctaactat atcaacaaca ctgggaggct tttgctcttc tggatttagc
     1321 atcaaccatc tggatattgc tccttcgtat gctggtatcc tcctgggcat cacaaataca
     1381 tttgccacta ttccaggaat ggttgggccc gtcattgcta aaagtctgac ccctgataac
     1441 actgttggag aatggcaaac cgtgttctat attgctgctg ctattaatgt ttttggtgcc
     1501 attttcttta cactattcgc caaaggtgaa gtacaaaact gggctctcaa tgatcaccat
     1561 ggacacagac actgaaggaa ccaataaata atcctgcctc tattaatgta tttttattta
     1621 tcatgtaacc tcaaagtgcc ttctgtattg tgtaagcatt ctatgtcttt ttttaattgt
     1681 acttgtatta gatttttaag gcctataatc atgaaatatc actagttgcc agaataataa
     1741 aatgaactgt gtttaattat gaataatatg taagctagga cttctacttt aggttcacat
     1801 acctgcctgc tagtcgggca acatgaagta ggacagttct gttgattttt tagggccata
     1861 ctaaagggaa tgagctgaaa cagacctcct gatacctttg cttaattaaa ctagatgata
     1921 attctcaggt actgataaac acctgttgtt gttcactttc ctcataaaaa ttgtcagctc
     1981 tctctgacac ttagacctca aactttagca tctctgtgga gctgccatcc actgtataat
     2041 ttcgcctggc aactggactg aggggagtgt gcccaggcag ctgccaagca ctccctccct
     2101 ggcttcaggg tcagagtgcc cagcgtttat cagaggcagc atccaagccc agagccagtg
     2161 tcgactcttc ggctggtgcc tttcctctga ggggctatca atgtgtagat aaagccctga
     2221 gtaggcaaga gcagtgagat ccactgctat ggtcttgata catcctcaaa ctttcccttc
     2281 ccagcacaga ggaatattgg ctggcatgca acctgcaaaa gaaaaatgcg aagcggccgg
     2341 gcacggtggc tcatgcctgt agtcccagca ctttgggggg ctgaggtggg cgaatcatga
     2401 gatcaggagt tcgagaccag cctggccagc atggtgaaac cccatctcta ctaaaaatac
     2461 aaaaaattag ctgggcgtgg tgacgggcgc ctgtaatccc agatactcag gaggctgagg
     2521 taggagaatc acttgaacct gggagatgga agttgcagtg aaccaagatc acgccactgc
     2581 actccagcct gggcgatgga gcgagactcc aactcaaaaa aaaaaaaaga ataaagaaag
     2641 aaaagtgcga tgcccagtca atcacaaata agatcatcct ggtttaaatc tactctcaca
     2701 tggatcacag tataaatttc tatgtgctgt gttttgttcg tttgtatttt gtagagatgg
     2761 ggtctcgttt tgtcgcccag gctggttttg aactcctggc ttcaagcgat cctcctgtct
     2821 cggcctcaca aagtgttgag actacaggca tgagccactg tgcccagcct gttctatgtt
     2881 tttaagctac acgagaattt tttttttaat taattctcac tgtttgttca gtctgtcttc
     2941 atctaagttt gtgttgcagt ttaaagttaa agtgactttt aaaggccaca tcacctgaga
     3001 ctagggtaat catctttact tctggttcct gaaatcatat ttttccagtg gaccatcctc
     3061 cagtggctgt ggttgttgag catgctttca gaacacctat gtggcttaaa acttagttta
     3121 tgttttgtgt tcaacactac gtgtaatatt ttaaaactgt ttaatgtgat gtgaatacat
     3181 ttatgtacat ttatttttaa atttgtaaat agctttaaat tgctatggca atgtttcttt
     3241 tataaatcat caaaataaac ctttgtgaat tgaaaaaaaa aaaaaaaaaa aa
//

LOCUS       NM_013282               3828 bp    mRNA    linear   PRI 18-DEC-2004
DEFINITION  Homo sapiens ubiquitin-like, containing PHD and RING finger
            domains, 1 (UHRF1), mRNA.
ACCESSION   NM_013282
VERSION     NM_013282.2  GI:16507203
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3828)
  AUTHORS   Unoki,M., Nishidate,T. and Nakamura,Y.
  TITLE     ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG
            through its SRA domain
  JOURNAL   Oncogene 23 (46), 7601-7610 (2004)
   PUBMED   15361834
  REMARK    GeneRIF: ICBP90 is involved in cell proliferation by way of
            methylation-mediated regulation of certain genes.
REFERENCE   2  (bases 1 to 3828)
  AUTHORS   Abbady,A.Q., Bronner,C., Trotzier,M.A., Hopfner,R., Bathami,K.,
            Muller,C.D., Jeanblanc,M. and Mousli,M.
  TITLE     ICBP90 expression is downregulated in apoptosis-induced Jurkat
            cells
  JOURNAL   Ann. N. Y. Acad. Sci. 1010, 300-303 (2003)
   PUBMED   15033738
  REMARK    GeneRIF: Apoptosis is dependent upon ICBP90 expression
            downregulation and ICBP90 exhibits anti-apoptotic properties.
REFERENCE   3  (bases 1 to 3828)
  AUTHORS   Mousli,M., Hopfner,R., Abbady,A.Q., Mont, Jeanblanc,M., Oudet,P.,
            Louis,B. and Bronner,C.
  TITLE     ICBP90 belongs to a new family of proteins with an expression that
            is deregulated in cancer cells
  JOURNAL   Br. J. Cancer 89 (1), 120-127 (2003)
  MEDLINE   22721419
   PUBMED   12838312
  REMARK    GeneRIF: ICBP90 expression altered in cancer cell lines and
            upregulated by E2F-1 overexpression, with efficiency depending on
            cancer status of cell line
REFERENCE   4  (bases 1 to 3828)
  AUTHORS   Hopfner,R., Mousli,M., Jeltsch,J.M., Voulgaris,A., Lutz,Y.,
            Marin,C., Bellocq,J.P., Oudet,P. and Bronner,C.
  TITLE     ICBP90, a novel human CCAAT binding protein, involved in the
            regulation of topoisomerase IIalpha expression
  JOURNAL   Cancer Res. 60 (1), 121-128 (2000)
  MEDLINE   20110783
   PUBMED   10646863
REFERENCE   5  (bases 1 to 3828)
  AUTHORS   Ku,D.H., Chang,C.D., Koniecki,J., Cannizzaro,L.A.,
            Boghosian-Sell,L., Alder,H. and Baserga,R.
  TITLE     A new growth-regulated complementary DNA with the sequence of a
            putative trans-activating factor
  JOURNAL   Cell Growth Differ. 2 (4), 179-186 (1991)
  MEDLINE   91329275
   PUBMED   1868030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF274048.1.
            On Oct 29, 2001 this sequence version replaced gi:7019430.
            
            Summary: UHRF1 binds to an inverted CCAAT box in the promoter of
            topoisomerase II-alpha (TOP2A; MIM 126430). TOP2A introduces
            transient double-stranded breaks in DNA, which are required during
            the cell cycle for DNA replication, chromosome condensation, and
            segregation. UHRF1 is likely involved in TOPO2A expression (Hopfner
            et al., 2000 [PubMed 10646863]).[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..3828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3828
                     /gene="UHRF1"
                     /note="synonyms: Np95, ICBP90, RNF106, huNp95, FLJ21925"
                     /db_xref="GeneID:29128"
                     /db_xref="MIM:607990"
     CDS             85..2466
                     /gene="UHRF1"
                     /note="transcription factor ICBP90; ICBP90 amino acids
                     746..793;
                     go_component: ubiquitin ligase complex [goid 0000151]
                     [evidence IEA];
                     go_function: zinc ion binding [goid 0008270] [evidence
                     IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 1868030];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 10646863];
                     go_function: ubiquitin-protein ligase activity [goid
                     0004842] [evidence IEA];
                     go_function: RNA polymerase II transcription factor
                     activity [goid 0003702] [evidence TAS] [pmid 10646863];
                     go_process: cell proliferation [goid 0008283] [evidence
                     TAS] [pmid 10646863];
                     go_process: protein ubiquitination [goid 0016567]
                     [evidence IEA];
                     go_process: regulation of transcription from Pol II
                     promoter [goid 0006357] [evidence TAS] [pmid 10646863]"
                     /codon_start=1
                     /product="ubiquitin-like, containing PHD and RING finger
                     domains, 1"
                     /protein_id="NP_037414.2"
                     /db_xref="GI:16507204"
                     /db_xref="GeneID:29128"
                     /db_xref="MIM:607990"
                     /translation="MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQR
                     LFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQS
                     ESDKSSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVT
                     RKAPSRDEPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLE
                     VGQVVMLNYNPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDE
                     VFKIERPGEGSPMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCD
                     ECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSS
                     SQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIH
                     GRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRAL
                     ALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWP
                     EKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKEN
                     SKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSS
                     LIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQ
                     HNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR"
     misc_feature    85..306
                     /gene="UHRF1"
                     /note="Region: ubiquitin-like domain"
     misc_feature    976..1179
                     /gene="UHRF1"
                     /note="Region: PHD zinc finger"
     misc_feature    1210..1239
                     /gene="UHRF1"
                     /note="Region: putative NLS"
     misc_feature    2209..2463
                     /gene="UHRF1"
                     /note="Region: RING zinc finger"
ORIGIN      
        1 cgactcctta gagcatggca tggctcagag gtgctggtaa aactgatggg ggtttttgct
       61 gtccctcccc tcagcgccga caccatgtgg atccaggttc ggaccatgga cgggaggcag
      121 acccacacgg tggactcgct gtccaggctg accaaggtgg aggagctgag gcggaagatc
      181 caggagctgt tccacgtgga gccaggcctg cagaggctgt tctacagggg caaacagatg
      241 gaggacggcc ataccctctt cgactacgag gtccgcctga atgacaccat ccagctcctg
      301 gtccgccaga gcctcgtgct cccccacagc accaaggagc gggactccga gctctccgac
      361 accgactccg gctgctgcct gggccagagt gagtcagaca agtcctccac ccacggcgag
      421 gcggccgccg agactgacag caggccagcc gatgaggaca tgtgggatga gacggaattg
      481 gggctgtaca aggtcaatga gtacgtcgat gctcgggaca cgaacatggg ggcgtggttt
      541 gaggcgcagg tggtcagggt gacgcggaag gccccctccc gggacgagcc ctgcagctcc
      601 acgtccaggc cggcgctgga ggaggacgtc atttaccacg tgaaatacga cgactacccg
      661 gagaacggcg tggtccagat gaactccagg gacgtccgag cgcgcgcccg caccatcatc
      721 aagtggcagg acctggaggt gggccaggtg gtcatgctca actacaaccc cgacaacccc
      781 aaggagcggg gcttctggta cgacgcggag atctccagga agcgcgagac caggacggcg
      841 cgggaactct acgccaacgt ggtgctgggg gatgattctc tgaacgactg tcggatcatc
      901 ttcgtggacg aagtcttcaa gattgagcgg ccgggtgaag ggagccccat ggttgacaac
      961 cccatgagac ggaagagcgg gccgtcctgc aagcactgca aggacgacgt gaacagactc
     1021 tgccgggtct gcgcctgcca cctgtgcggg ggccggcagg accccgacaa gcagctcatg
     1081 tgcgatgagt gcgacatggc cttccacatc tactgcctgg acccgcccct cagcagtgtt
     1141 cccagcgagg acgagtggta ctgccctgag tgccggaatg atgccagcga ggtggtactg
     1201 gcgggagagc ggctgagaga gagcaagaag aaggcgaaga tggcctcggc cacatcgtcc
     1261 tcacagcggg actggggcaa gggcatggcc tgtgtgggcc gcaccaagga atgtaccatc
     1321 gtcccgtcca accactacgg acccatcccg gggatccccg tgggcaccat gtggcggttc
     1381 cgagtccagg tcagcgagtc gggtgtccat cggccccacg tggctggcat acacggccgg
     1441 agcaacgacg gagcgtactc cctagtcctg gcggggggct atgaggatga cgtggaccat
     1501 gggaattttt tcacatacac gggtagtggt ggtcgagatc tttccggcaa caagaggacc
     1561 gcggaacagt cttgtgatca gaaactcacc aacaccaaca gggcgctggc tctcaactgc
     1621 tttgctccca tcaatgacca agaaggggcc gaggccaagg actggcggtc ggggaagccg
     1681 gtcagggtgg tgcgcaatgt caagggtggc aagaatagca agtacgcccc cgctgagggc
     1741 aaccgctacg atggcatcta caaggttgtg aaatactggc ccgagaaggg gaagtccggg
     1801 tttctcgtgt ggcgctacct tctgcggagg gacgatgatg agcctggccc ttggacgaag
     1861 gaggggaagg accggatcaa gaagctgggg ctgaccatgc agtatccaga aggctacctg
     1921 gaagccctgg ccaaccgaga gcgagagaag gagaacagca agagggagga ggaggagcag
     1981 caggaggggg gcttcgcgtc ccccaggacg ggcaagggca agtggaagcg gaagtcggca
     2041 ggaggtggcc cgagcagggc cgggtccccg cgccggacat ccaagaaaac caaggtggag
     2101 ccctacagtc tcacggccca gcagagcagc ctcatcagag aggacaagag caacgccaag
     2161 ctgtggaatg aggtcctggc gtcactcaag gaccggccgg cgagcggcag cccgttccag
     2221 ttgttcctga gtaaagtgga ggagacgttc cagtgtatct gctgtcagga gctggtgttc
     2281 cggcccatca cgaccgtgtg ccagcacaac gtgtgcaagg actgcctgga cagatccttt
     2341 cgggcacagg tgttcagctg ccctgcctgc cgctacgacc tgggccgcag ctatgccatg
     2401 caggtgaacc agcctctgca gaccgtcctc aaccagctct tccccggcta cggcaatggc
     2461 cggtgatctc caagcacttc tcgacaggcg ttttgctgaa aacgtgtcgg agggctcgtt
     2521 catcggcact gattttgttc ttagtgggct taacttaaac aggtagtgtt tcctccgttc
     2581 cctaaaaagg tttgtcttcc ttttttttta tttttatttt tcaaatctat acattttcag
     2641 gaatttatgt attctggcta aaagttggac ttctcagtat tgtgtttagt tctttgaaaa
     2701 cataaaagcc tgcaatttct cgacaaaaca acacaagatt ttttaaagat ggaatcagaa
     2761 actacgtggt gtggaggctg ttgatgtttc tggtgtcaag ttctcagaag ttgctgccac
     2821 caactcttta agaaggcgac aggatcagtc cttctctagg gttctggccc ccaaggtcag
     2881 agcaagcatc ttcctgacag cattttgtca tctaaagtcc agtgacatgg ttccccgtgg
     2941 tggcccgtgg cagcccgtgg catggcgtgg ctcagctgtc tgttgaagtt gttgcaagga
     3001 aaagaggaaa catctcgggc ctagttcaaa cctttgcctc aaagccatcc cccaccagac
     3061 tgcttagcgt ctgagatccg cgtgaaaagt cctctgccca cgagagcagg gagttggggc
     3121 cacgcagaaa tggcctcaag gggactctgc tccacgtggg gccaggcgtg tgactgacgc
     3181 tgtccgacga aggcggccac ggacggacgc cagcacacga agtcacgtgc aagtgccttt
     3241 gattcgttcc ttctttctaa agacgacagt ctttgttgtt agcactgaat tattgaaaat
     3301 gtcaaccaga ttctagaaac tgcggtcatc cagttcttcc tgacaccgga tgggtgcttg
     3361 ggaaccgttt gagccttata gatcatttac attcaatttt tttaactcag caagtgagaa
     3421 cttacaagag ggtttttttt taattttttt ttctcttaat gaacacattt tctaaatgaa
     3481 ttttttttgt agttactgta tatgtaccaa gaaagatata acgttagggt ttggttgttt
     3541 ttgtttttgt attttttttc ttttgaaagg gtttgttaat ttttctaatt ttaccaaagt
     3601 ttgcagccta tacctcaata aaacagggat attttaaatc acatacctgc agacaaactg
     3661 gagcaatgtt atttttaaag ggtttttttc acctccttat tcttagatta ttaatgtatt
     3721 agggaagaat gagacaattt tgtgtaggct ttttctaaag tccagtactt tgtccagatt
     3781 ttagattctc agaataaatg tttttcacag attgaaaaaa aaaaaaaa
//

LOCUS       NM_013411               2146 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens adenylate kinase 2 (AK2), transcript variant AK2B,
            mRNA.
ACCESSION   NM_013411
VERSION     NM_013411.2  GI:26665888
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Noma,T., Song,S., Yoon,Y.S., Tanaka,S. and Nakazawa,A.
  TITLE     cDNA cloning and tissue-specific expression of the gene encoding
            human adenylate kinase isozyme 2
  JOURNAL   Biochim. Biophys. Acta 1395 (1), 34-39 (1998)
   PUBMED   9434148
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Lee,Y., Kim,J.W., Lee,S.M., Kim,H.J., Lee,K.S., Park,C. and
            Choe,I.S.
  TITLE     Cloning and expression of human adenylate kinase 2 isozymes:
            differential expression of adenylate kinase 1 and 2 in human muscle
            tissues
  JOURNAL   J. Biochem. 123 (1), 47-54 (1998)
   PUBMED   9504408
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Lee,Y., Kim,J.W., Lee,I.A., Kang,H.B., Choe,Y.K., Lee,H.G.,
            Lim,J.S., Kim,H.J., Park,C. and Choe,I.S.
  TITLE     Cloning and characterization of cDNA for human adenylate kinase 2A
  JOURNAL   Biochem. Mol. Biol. Int. 39 (4), 833-842 (1996)
   PUBMED   8843353
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Bruns,G.A. and Regina,V.M.
  TITLE     Adenylate kinase 2, a mitochondrial enzyme
  JOURNAL   Biochem. Genet. 15 (5-6), 477-486 (1977)
   PUBMED   195572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U54645.1, AB005622.1 and
            U84371.1.
            On Dec 13, 2002 this sequence version replaced gi:7524345.
            
            Summary: Adenylate kinases are involved in regulating the adenine
            nucleotide composition within a cell by catalyzing the reversible
            transfer of phosphate groups among adenine nucleotides. Three
            isozymes of adenylate kinase, namely 1, 2, and 3, have been
            identified in vertebrates; this gene encodes isozyme 2. Expression
            of these isozymes is tissue-specific and developmentally regulated.
            Isozyme 2 is localized in the mitochondrial intermembrane space and
            may play a role in apoptosis. Transcript variants encoding distinct
            isoforms have been identified for this gene.
            
            Transcript Variant: This variant (AK2B) differs in the 3' UTR and
            3' coding region compared to variant AK2A, resulting in a shorter
            isoform (b) with a different C-terminus compared to isoform a.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34"
     gene            1..2146
                     /gene="AK2"
                     /note="synonym: ADK2"
                     /db_xref="GeneID:204"
                     /db_xref="MIM:103020"
     CDS             43..741
                     /gene="AK2"
                     /EC_number="2.7.4.3"
                     /note="isoform b is encoded by transcript variant AK2B;
                     adenylate kinase, mitochondrial; adenylate kinase
                     isoenzyme 2, mitochondrial; ATP-AMP transphosphorylase;
                     go_component: mitochondrion [goid 0005739] [evidence IEA];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: kinase activity [goid 0016301] [evidence
                     IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: adenylate kinase activity [goid 0004017]
                     [evidence TAS] [pmid 9504408]"
                     /codon_start=1
                     /product="adenylate kinase 2 isoform b"
                     /protein_id="NP_037543.1"
                     /db_xref="GI:7524346"
                     /db_xref="GeneID:204"
                     /db_xref="MIM:103020"
                     /translation="MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHL
                     ATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFP
                     RTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPK
                     EPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDV
                     VFASILAAFSKATS"
     polyA_signal    1628..1633
                     /gene="AK2"
     polyA_site      1648
                     /gene="AK2"
                     /evidence=experimental
     misc_feature    2146
                     /gene="AK2"
                     /note="location of 3'-most polyA site is unknown"
ORIGIN      
        1 gtgaggcgtg cgaactggtg gcagtgagag acttcggcgg acatggctcc cagcgtgcca
       61 gcggcagaac ccgagtatcc taaaggcatc cgggccgtgc tgctggggcc tcccggggcc
      121 ggtaaaggga cccaggcacc cagattggct gaaaacttct gtgtctgcca tttagctact
      181 ggggacatgc tgagggccat ggtggcttct ggctcagagc taggaaaaaa gctgaaggca
      241 actatggatg ctgggaaact ggtgagtgat gaaatggtag tggagctcat tgagaagaat
      301 ttggagaccc ccttgtgcaa aaatggtttt cttctggatg gcttccctcg gactgtgagg
      361 caggcagaaa tgctcgatga cctcatggag aagaggaaag agaagcttga ttctgtgatt
      421 gaattcagca tcccagactc tctgctgatc cgaagaatca caggaaggct gattcacccc
      481 aagagtggcc gttcctacca cgaggagttc aaccctccaa aagagcccat gaaagatgac
      541 atcaccgggg aacccttgat ccgtcgatca gatgataatg aaaaggcctt gaaaatccgc
      601 ctgcaagcct accacactca aaccacccca ctcatagagt actacaggaa acgggggatc
      661 cactccgcca tcgatgcatc ccagaccccc gatgtcgtgt tcgcaagcat cctagcagcc
      721 ttctccaaag ccacatccta gtatcagaag gccaggcgag actgcaacac tgctcatcac
      781 cccgcggcgt gatccctgct cttaggtgct gggcagaggg gaagggtggt cagggtgagg
      841 atggtgaggg agggctggtg aggggctcag aggaatactt ggaacaacag cagtgttatt
      901 gtagtgtggc agtttctttt atacataggt gagagttttt aaagtgtaag ggaaaaatta
      961 attttttaaa aaacaccatg cttggagggt gggggtagaa atagacacaa tattatttct
     1021 aaggaatcgg gttttcattt actctggact ggtgaaaata ttttttaaag ccagtgctct
     1081 aagacctcag cttttatctc agaaccccat gggttccaga ccaagagtac aggaaatcaa
     1141 attgttgtcc tgtctgtcta tagcttggaa cagggagctt tgattactga ctccggttcc
     1201 acacactgta agatcaaaaa accatctcca catttgaaag agatgtaagg tgtattcata
     1261 gggatggtgg ctcaacaaat caagcaaact ggaatcaagg ggagggggaa gggaatgaaa
     1321 tggaaaggga ggctgattcc cttcccctga cttaccacta atttactagg ctacctactt
     1381 tcatgagtaa cctctcacag ctacccagca catgccacaa tcctatgctc ttgccttctt
     1441 ttatctgcac tgtgtgaagg gactctttta aataaatgag caagtgtcct aagctatgtc
     1501 atccaaagat tgtcctttcc attctcaaat cctgtgactg ggatcactca acagcactgt
     1561 gatgtattat tttcaatgag gtgcctttct taactgacca aatgctgcct tgtttggccc
     1621 ctaaatcaat aaaatatgtt aaaatttgta tcccctgttg tggcattttt tttagataat
     1681 ctaagctaga aaaatgacat tgaattctgg acctggctgg aaggaaaaga agccctttct
     1741 tgtcgctggc agctgtgtgg tagggaggtc caagtatgtg catatgagat aagcctgcaa
     1801 cctcttgacc ttcagctcct atgcaggctt ctcttgagcc cagagacaag gcagcttggt
     1861 ctagtggaga tagcactgtg cttggagttc aggggaccta ggacaaatcc cagccagtta
     1921 gttattcact gtgctcctgt ttcctcagct gaaaaaggaa gttggttatg ccaccttctt
     1981 ggccttaatg gcattaaatg aaatttatag gaagaaggtt tttgctcagt acctggcatg
     2041 caacagacat tggataaatg ttagttggat ccagatatac acagaaagat atctgcttcc
     2101 tgccaggctg gataactgtt gaatggacac ttgtccatag tctaga
//

LOCUS       NM_014170               1364 bp    mRNA    linear   PRI 07-JAN-2005
DEFINITION  Homo sapiens HSPC135 protein (HSPC135), transcript variant 1, mRNA.
ACCESSION   NM_014170
VERSION     NM_014170.2  GI:56549684
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Zhang,Q.H., Ye,M., Wu,X.Y., Ren,S.X., Zhao,M., Zhao,C.J., Fu,G.,
            Shen,Y., Fan,H.Y., Lu,G., Zhong,M., Xu,X.R., Han,Z.G., Zhang,J.W.,
            Tao,J., Huang,Q.H., Zhou,J., Hu,G.X., Gu,J., Chen,S.J. and Chen,Z.
  TITLE     Cloning and functional analysis of cDNAs with open reading frames
            for 300 previously undefined genes expressed in CD34+ hematopoietic
            stem/progenitor cells
  JOURNAL   Genome Res. 10 (10), 1546-1560 (2000)
  MEDLINE   20499367
   PUBMED   11042152
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BI830308.1, BC000003.1,
            AF161484.1, CA429378.1 and AI367201.1.
            On Dec 10, 2004 this sequence version replaced gi:7661795.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..1364
                     /gene="HSPC135"
                     /db_xref="GeneID:29083"
     CDS             48..902
                     /gene="HSPC135"
                     /note="isoform 1 is encoded by transcript variant 1;
                     go_function: GTP binding [goid 0005525] [evidence IEA]"
                     /codon_start=1
                     /product="HSPC135 protein isoform 1"
                     /protein_id="NP_054889.2"
                     /db_xref="GI:56549685"
                     /db_xref="GeneID:29083"
                     /translation="MAAPGLRLGAGRLFEMPAVLERLSRYNSTSQAFAEVLRLPKQQL
                     RKLLYPLQEVERFLAPYGRQDLHLRIFDPSPEDIARADNIFTATERNRIDYVSSAVRI
                     DHAPDLPRPEVCFIGRSNVGKSSLIKALFSLAPEVEVRVSKKPGHTKKMNFFKVGKHF
                     TVVDMPGYGFRAPEDFVDMVETYLKERRNLKRTFLLVDSVVGIQKTDNIAIEMCEEFA
                     LPYVIVLTKIDKSSKGHLLKQVLQIQKFVNMKTQGCFPQLFPVSAVTFSGIHLLRCFI
                     ASVTGSLD"
     polyA_site      1357
                     /gene="HSPC135"
ORIGIN      
        1 caggccacag gagtaaaatc tctctgcccg tcttctggga agggagaatg gcggcgcccg
       61 ggctgcggct gggagcggga agactctttg aaatgcctgc ggtgctagag cgactgagcc
      121 gctataatag cacgtcccaa gcttttgctg aggtgctgcg gctgccgaag cagcagctga
      181 ggaagctgct gtacccgctg caggaagtag agcggttcct cgccccctac gggaggcaag
      241 accttcacct gcgtatcttt gacccaagcc cggaggacat agccagggcg gacaacatct
      301 tcacggccac tgaacggaac cgcatcgact acgtcagctc cgccgtccgt atcgaccacg
      361 ccccggacct tccgcggcca gaggtgtgtt ttataggcag aagcaatgtt ggaaaatcat
      421 ctctaatcaa ggctttattt tcactggccc ctgaggttga agtcagagtc tccaaaaaac
      481 caggacacac aaagaaaatg aattttttca aagttggaaa acattttaca gtggtggaca
      541 tgccaggtta tggctttaga gcacctgaag attttgttga catggtagag acctatctaa
      601 aagaacgaag gaacttgaag agaacatttt tattagtgga tagcgttgtt ggaattcaaa
      661 aaacagacaa tattgccata gaaatgtgtg aagaatttgc attaccttat gtgattgtat
      721 taacaaaaat tgacaaatct tccaagggac atcttttaaa acaagtgctt cagatccaga
      781 aatttgttaa catgaaaact caaggatgtt ttcctcagtt gtttcctgta agtgctgtga
      841 ccttttctgg aatccacctg ttgagatgct ttatagccag tgtaacagga agtcttgact
      901 aatggttccc ggtttagctg aagattcaaa aaaaaaaaaa aaagctttat gctaactgga
      961 gttaaatacc tagaagaatt tcaacattgt tttaaatgtt gtgcatctgt aacttcagga
     1021 ggatcacttg agctttaaaa cctgtgcctt ctcgaaacaa gaatttgtgc ctgaggtgaa
     1081 aaaagtttgt aagttattga attatggtgt tcattagaac agctactagc tgattcccct
     1141 attttaacaa actgacaaga gcacatccat aaaatgaaaa cctgttacaa ctatgtacag
     1201 aagggtttga cgttttattg ggcttttgtc ttttaaagaa tatgtctact atgggtattt
     1261 tttttttaaa tgttaaaatg ggctaggtaa aagggggctg cttttctgtt aagcatcgat
     1321 aggtaagttg atggataaaa gttactatgt aagcctaaaa aaaa
//

LOCUS       NM_014300               1399 bp    mRNA    linear   PRI 13-JAN-2005
DEFINITION  Homo sapiens SEC11-like 1 (S. cerevisiae) (SEC11L1), mRNA.
ACCESSION   NM_014300
VERSION     NM_014300.2  GI:33859831
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
  MEDLINE   22388257
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC014508.1.
            On Aug 19, 2003 this sequence version replaced gi:7657608.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.3"
     gene            1..1399
                     /gene="SEC11L1"
                     /note="synonyms: SPC18, SPCS4A, sid2895, 1810012E07Rik"
                     /db_xref="GeneID:23478"
     CDS             369..908
                     /gene="SEC11L1"
                     /note="signal peptidase complex (18kD);
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_component: microsome [goid 0005792] [evidence IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence IEA];
                     go_function: serine-type peptidase activity [goid 0008236]
                     [evidence IEA];
                     go_process: signal peptide processing [goid 0006465]
                     [evidence IEA];
                     go_process: proteolysis and peptidolysis [goid 0006508]
                     [evidence IEA]"
                     /codon_start=1
                     /product="SEC11-like 1"
                     /protein_id="NP_055115.1"
                     /db_xref="GI:7657609"
                     /db_xref="GeneID:23478"
                     /translation="MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITG
                     SESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIH
                     EKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYP
                     KFKYAVLFLLGLFVLVHRE"
ORIGIN      
        1 gaaggtggca gagcagcctc cccaactaag cctgggtcgc cgcctcggtg aagggccgcg
       61 gggccgagcg cgggaagtgg cgtccagtcg gtttttggca ggcgagagcc agagcgtgag
      121 aaccctccca cggcgaggcc aagccctgag actggactag caaggtcgtg agtctctctg
      181 tcagctctcc gcagcgaagg ggcgcggggg gcggggaccg tgcccgaccg tgccagctcc
      241 cgctccggaa gcggaagtgc aagcactgcg gggtcctgtc cagtgtgagc ccgacccgag
      301 ctccagtagt tccgcccgct ggtcatcgcg ccctttcccc tgccggtgtc ctgctcgccg
      361 tccccgccat gctgtctcta gactttttgg acgatgtgcg gcggatgaac aagcggcagc
      421 tctattatca agtcctaaat tttggaatga ttgtctcatc ggcactaatg atctggaagg
      481 ggttaatggt aataactgga agtgaaagtc cgattgtagt ggtgctcagt ggcagcatgg
      541 aacctgcatt tcatagagga gatcttctct ttctaacaaa tcgagttgaa gatcccatac
      601 gagtgggaga aattgttgtt tttaggatag aaggaagaga gattcctata gttcaccgag
      661 tcttgaagat tcatgaaaag caaaatgggc atatcaagtt tttgaccaaa ggagataata
      721 atgcggttga tgaccgaggc ctctataaac aaggacaaca ttggctagag aaaaaagatg
      781 ttgtggggag agccagggga tttgttcctt atattggaat tgtgacgatc ctcatgaatg
      841 actatcctaa atttaagtat gcagttctct ttttgctggg tttattcgtg ctggttcatc
      901 gtgagtaaga agcctgcctt gctgttcctg ggaagatgcc atagttttcg ttactggatg
      961 tttggagtag atactggtct gtgattggtg gaatggagaa cacacgtgtt ggtgcttctg
     1021 ggtagcactg gtttgcatta gtttatgttt ccatgccaga gtttgtgtgg gcgggcgcat
     1081 gtgcaccaca gagtgcactc gaggggactt tcagtcacag gatttcataa ttgtcattgt
     1141 cacactttca aatttttgta catcagtgaa tttttttata ttaaaaggtt gagccaaagc
     1201 ccccagtgtt tgtattttga agccaagctt cacttctaaa gtgcctacag agacttgtaa
     1261 atgaaaatgc agctctgcac gagtttgaaa ccgtcatacc tccttctatt aggaatggca
     1321 tatactgagg tggtcgtaag tcttaacttc taaaatttta aataaaagac tttgcacatt
     1381 gaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_014320               1282 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens heme binding protein 2 (HEBP2), mRNA.
ACCESSION   NM_014320
VERSION     NM_014320.2  GI:41393567
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Zylka,M.J. and Reppert,S.M.
  TITLE     Discovery of a putative heme-binding protein family (SOUL/HBP) by
            two-tissue suppression subtractive hybridization and database
            searches
  JOURNAL   Brain Res. Mol. Brain Res. 74 (1-2), 175-181 (1999)
  MEDLINE   20109330
   PUBMED   10640688
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Bohn,H. and Winckler,W.
  TITLE     Isolation and characterization of five new soluble placental tissue
            proteins (PP22, PP23, PP24, PP25, PP26)
  JOURNAL   Arch. Gynecol. Obstet. 248 (3), 111-115 (1991)
  MEDLINE   91207071
   PUBMED   2018407
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BF974311.1, AF117616.1 and
            AK057928.1.
            On Jan 30, 2004 this sequence version replaced gi:7657602.
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1282
                     /gene="HEBP2"
                     /note="synonyms: PP23, SOUL, C6orf34"
                     /db_xref="GeneID:23593"
                     /db_xref="MIM:605825"
     CDS             298..915
                     /gene="HEBP2"
                     /note="putative heme-binding protein; chromosome 6 open
                     reading frame 34; placental protein 23; RP3-422G23.1"
                     /codon_start=1
                     /product="heme binding protein 2"
                     /protein_id="NP_055135.1"
                     /db_xref="GI:7657603"
                     /db_xref="GeneID:23593"
                     /db_xref="MIM:605825"
                     /translation="MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYG
                     PAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSE
                     STITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLAS
                     ILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE"
ORIGIN      
        1 ggcgggccga agcgaggtgc ggctccctgt cgccgcggag gggcgggggc aggacgcgca
       61 actccggccg gagctgtccg gggtcgtgag ccggccccgc cttggtggcg gcgccccctc
      121 gcggtccaga ggcagacgca tcgggtgggc tcgggtctcc agcccggccg ggaggaggga
      181 ccgggtctgc ggagcgggga ctcggggcct cggcggggcg cgcacacgca ggcggggcgg
      241 cccggggtgc ggggcctctg cgcggctgac caggctccca gagcgtcagc gccgcccatg
      301 gccgagccgc tccagccaga ccccggggcg gccgaggacg cggcggccca agctgtggag
      361 acgccgggct ggaaggcccc ggaggacgcc ggcccccagc ccggaagtta tgagatccga
      421 cactatggac cagccaagtg ggtcagcacg tccgtggagt ctatggactg ggattcagcc
      481 atccagacgg gctttacgaa actgaacagc tacattcaag gcaaaaacga gaaagagatg
      541 aaaataaaga tgacagctcc agtgacaagc tacgtggagc ctggttcagg tccttttagt
      601 gagtctacca ttaccatttc cctgtatatt ccctctgaac agcaatttga tccacccagg
      661 cctttagagt cagatgtctt cattgaagat agagccgaaa tgactgtgtt tgtacggtct
      721 ttcgatggat tttctagtgc ccaaaagaat caagaacaac ttttgacatt agcaagcatt
      781 ttaagggaag atggaaaagt tttcgatgag aaggtttact acactgcagg ctacaacagt
      841 cctgtcaaat tgcttaatag aaataatgaa gtgtggttga ttcaaaaaaa tgaacccacc
      901 aaagaaaacg aatgagaaaa atgaaaggaa gttctgctgt cagaggcaaa acatctgttt
      961 atcatagaca tcaacatgac ctataagtaa agtgcgtgtc tagtgtcttc tattgagagt
     1021 actactatta attaagctta tttccaatgt gcctttttaa tgcttgaagt tttatctaca
     1081 tacacaggta acagaggaca gtagtctgta aacatataaa tcggtcataa ctatcgtggt
     1141 ctttatttct gtgaggatct agggaaattt catgtcactt ccctccttca ctgcatcaca
     1201 atcatattcc cttttttttt tcttggattt gtgtcagttg gatgatatcc cctccagata
     1261 gtatcaataa aatgttaaaa tt
//

LOCUS       NM_014397               2596 bp    mRNA    linear   PRI 21-AUG-2004
DEFINITION  Homo sapiens NIMA (never in mitosis gene a)-related kinase 6
            (NEK6), mRNA.
ACCESSION   NM_014397
VERSION     NM_014397.3  GI:34147501
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Yin,M.J., Shao,L., Voehringer,D., Smeal,T. and Jallal,B.
  TITLE     The serine/threonine kinase Nek6 is required for cell cycle
            progression through mitosis
  JOURNAL   J. Biol. Chem. 278 (52), 52454-52460 (2003)
   PUBMED   14563848
  REMARK    GeneRIF: Nek6 kinase is required for the metaphase-anaphase
            transition
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Belham,C., Roig,J., Caldwell,J.A., Aoyama,Y., Kemp,B.E., Comb,M.
            and Avruch,J.
  TITLE     A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the
            Nek6 and Nek7 kinases
  JOURNAL   J. Biol. Chem. 278 (37), 34897-34909 (2003)
   PUBMED   12840024
  REMARK    GeneRIF: Activated by Nercc1/NEK9; part of the mitotic casscade
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Lizcano,J.M., Deak,M., Morrice,N., Kieloch,A., Hastie,C.J.,
            Dong,L., Schutkowski,M., Reimer,U. and Alessi,D.R.
  TITLE     Molecular basis for the substrate specificity of NIMA-related
            kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the
            hydrophobic motif of ribosomal S6 protein kinase and serum- and
            glucocorticoid-induced protein kinase in vivo
  JOURNAL   J. Biol. Chem. 277 (31), 27839-27849 (2002)
   PUBMED   12023960
  REMARK    GeneRIF: Molecular basis for the substrate specificity
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Hashimoto,Y., Akita,H., Hibino,M., Kohri,K. and Nakanishi,M.
  TITLE     Identification and characterization of Nek6 protein kinase, a
            potential human homolog of NIMA histone H3 kinase
  JOURNAL   Biochem. Biophys. Res. Commun. 293 (2), 753-758 (2002)
   PUBMED   12054534
  REMARK    GeneRIF: molecular cloning and characterization of Nek6
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Li,M.Z., Yu,L., Liu,Q., Chu,J.Y. and Zhao,S.Y.
  TITLE     Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33.
            3-->q34.11 by radiation hybrid mapping
  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 271-272 (1999)
   PUBMED   10702691
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC012761.2.
            On Aug 25, 2003 this sequence version replaced gi:19923406.
            
            Summary: The Aspergillus nidulans 'never in mitosis A' (NIMA) gene
            encodes a serine/threonine kinase that controls initiation of
            mitosis. NIMA-related kinases (NEKs) are a group of protein kinases
            that are homologous to NIMA. Evidence suggests that NEKs perform
            functions similar to those of NIMA.[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3-q34.11"
     gene            1..2596
                     /gene="NEK6"
                     /note="synonym: SID6-1512"
                     /db_xref="GeneID:10783"
                     /db_xref="MIM:604884"
     CDS             146..1087
                     /gene="NEK6"
                     /note="go_component: nucleus [goid 0005634] [evidence
                     IEA];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IMP] [pmid 12761501];
                     go_function: protein-tyrosine kinase activity [goid
                     0004713] [evidence IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence IEA];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence IEA];
                     go_process: positive regulation of I-kappaB
                     kinase/NF-kappaB cascade [goid 0043123] [evidence IMP]
                     [pmid 12761501]"
                     /codon_start=1
                     /product="putative serine-threonine protein kinase"
                     /protein_id="NP_055212.2"
                     /db_xref="GI:19923407"
                     /db_xref="GeneID:10783"
                     /db_xref="MIM:604884"
                     /translation="MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLAD
                     FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNH
                     PNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV
                     EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPER
                     IHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSE
                     KLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST"
ORIGIN      
        1 ccgagctgac gggcgtgcgg ccgctgcgcc gcaaactcgt gtgggaggca ccgctccagc
       61 cgcccgcggg ccagcgcacc ggtcccccag cggcagccga gcccgcccgc gcgccgttcg
      121 tgccctcgtg aggctggcat gcaggatggc aggacagccc ggccacatgc cccatggagg
      181 gagttccaac aacctctgcc acaccctggg gcctgtgcat cctcctgacc cacagaggca
      241 tcccaacacg ctgtcttttc gctgctcgct ggcggacttc cagatcgaaa agaagatagg
      301 ccgaggacag ttcagcgagg tgtacaaggc cacctgcctg ctggacagga agacagtggc
      361 tctgaagaag gtgcagatct ttgagatgat ggacgccaag gcgaggcagg actgtgtcaa
      421 ggagatcggc ctcttgaagc aactgaacca cccaaatatc atcaagtatt tggactcgtt
      481 tatcgaagac aacgagctga acattgtgct ggagttggct gacgcagggg acctctcgca
      541 gatgatcaag tactttaaga agcagaagcg gctcatcccg gagaggacag tatggaagta
      601 ctttgtgcag ctgtgcagcg ccgtggagca catgcattca cgccgggtga tgcaccgaga
      661 catcaagcct gccaacgtgt tcatcacagc cacgggcgtc gtgaagctcg gtgaccttgg
      721 tctgggccgc ttcttcagct ctgagaccac cgcagcccac tccctagtgg ggacgcccta
      781 ctacatgtca ccggagagga tccatgagaa cggctacaac ttcaagtccg acatctggtc
      841 cttgggctgt ctgctgtacg agatggcagc cctccagagc cccttctatg gagataagat
      901 gaatctcttc tccctgtgcc agaagatcga gcagtgtgac taccccccac tccccgggga
      961 gcactactcc gagaagttac gagaactggt cagcatgtgc atctgccctg acccccacca
     1021 gagacctgac atcggatacg tgcaccaggt ggccaagcag atgcacatct ggatgtccag
     1081 cacctgagcg tggatgcacc gtgccttatc aaagccagca ccactttgcc ttacttgagt
     1141 cgtcttctct tcgagtggcc acctggtagc ctagaacagc taagaccaca gggttcagca
     1201 ggttccccaa aaggctgccc agccttacag cagatgctga aggcagagca gctgagggag
     1261 gggcgctggc cacatgtcac tgatggtcag attccaaagt cctttcttta tactgttgtg
     1321 gacaatctca gctgggtcaa taagggcagg tggttcagcg agccacggca gccccctgta
     1381 tctggattgt aatgtgaatc tttagggtaa ttcctccagt gacctgtcaa ggcttatgct
     1441 aacaggagac ttgcaggaga ccgtgtgatt tgtgtagtga gcctttgaaa atggttagta
     1501 ccgggttcag tttagttctt ggtatctttt caatcaagct gtgtgcttaa tttactctgt
     1561 tgtaaaggga taaagtggaa atcatttttt tccgtggagt ggtgattctg ctaacatttt
     1621 tatctacgtt ttataacttg gtgagtgacg atgagagccc tgcacctggc cagagtgtca
     1681 caggcaaaag gcatcgggaa gcaggagcat cttcttggca gccaggctgg gccatcttct
     1741 cctggacacc tgctgtgtac caggaacttc gtcacctcct tgaatgctgg cggttcattt
     1801 catgatcagt gttaagcatt ttcctccatg ggaaggaagc atgggatata gaaaagcgaa
     1861 gggctgtcct ttacaaattc tggttctgca acttcctagc gtgactttgg gcttgggcaa
     1921 gtttcttagc cgttctgagc cttcatttcc tcatctgtac aatgagatta atagtaccta
     1981 tcatctacct tcaggattgc tgacagacag aatttgaaat aaaatatgca agttagctaa
     2041 tacaaaaagt agatgatcca aaaatggtag ccactcaccc ttcacaaact gaagtccatg
     2101 gaccacggaa gtcgagaatt aatgtacacc tgtatcatgt gtaggaaacc agaaatgtgt
     2161 tccttatttc ttgttcccaa acaggattaa ctgtgaagac taatttataa atgtgaacct
     2221 aagaaaactc cacctctgaa ggaaatcatt tgaattttgt ttttgtacgt aaagttaacc
     2281 ttccaattgt ctgagctgtc gtcactgact tcatgacagt ctggccctcc agacaagagc
     2341 agcgctggca tcgggcaggt gattcctgac acctgctgcc tgcaggcatt cactgaccag
     2401 gcctttcctg gaggaaacac ccagggccgg gcggctgctg tttccacacg tggactcgga
     2461 tctgctgtga caccgtcagc ccgacagtct ctccatatgc agcctttcct ctgtactttt
     2521 ctccatggtt gaaataaaac agggtgactg ggagttactt agaattcatg aagattttaa
     2581 aaaaaaaaaa aaaaaa
//

LOCUS       NM_014445               2488 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens stress-associated endoplasmic reticulum protein 1
            (SERP1), mRNA.
ACCESSION   NM_014445
VERSION     NM_014445.2  GI:19923408
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Yamaguchi,A., Hori,O., Stern,D.M., Hartmann,E., Ogawa,S. and
            Tohyama,M.
  TITLE     Stress-associated endoplasmic reticulum protein 1
            (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes
            membrane proteins during stress and facilitates subsequent
            glycosylation
  JOURNAL   J. Cell Biol. 147 (6), 1195-1204 (1999)
   PUBMED   10601334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL136807.1.
            On Apr 4, 2002 this sequence version replaced gi:7657551.
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..2488
                     /gene="SERP1"
                     /note="synonym: RAMP4"
                     /db_xref="GeneID:27230"
     CDS             316..516
                     /gene="SERP1"
                     /note="ribosome associated membrane protein 4;
                     go_component: ribosome [goid 0005840] [evidence TAS] [pmid
                     10601334];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence TAS] [pmid 10601334];
                     go_process: response to stress [goid 0006950] [evidence
                     TAS] [pmid 10601334];
                     go_process: protein amino acid glycosylation [goid
                     0006486] [evidence TAS] [pmid 10601334];
                     go_process: plasma membrane organization and biogenesis
                     [goid 0007009] [evidence TAS] [pmid 10601334]"
                     /codon_start=1
                     /product="stress-associated endoplasmic reticulum protein
                     1"
                     /protein_id="NP_055260.1"
                     /db_xref="GI:7657552"
                     /db_xref="GeneID:27230"
                     /translation="MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLA
                     LFIFVVCGSAIFQIIQSIRMGM"
     polyA_signal    2443..2448
                     /gene="SERP1"
     polyA_site      2464
                     /gene="SERP1"
ORIGIN      
        1 cttcctcttt cactccgcgc tcacggcggc ggccaaagcg gcggcgacgg cggcgcgaga
       61 acgacccggc ggccagttct cttcctcctg cgcacctgcc ccgctcggtc agtcagtcgg
      121 cggccggcgc ccggcttgtg ctcagacctc gcgcttgcgg cgcccaggcc cagcggccgt
      181 agctagcgtc tggcctgaga acctcggcgc tccggcggcg cgggcaccac gagccgagcc
      241 tcgcagcggc tccagaggag gcaggcgagt gagcgagtcc gaggggtggc cggggcaggt
      301 ggtggcgccg cgaagatggt cgccaagcaa aggatccgta tggccaacga gaagcacagc
      361 aagaacatca cccagcgcgg caacgtcgcc aagacctcga gaaatgcccc cgaagagaag
      421 gcgtctgtag gaccctggtt attggctctc ttcatttttg ttgtctgtgg ttctgcaatt
      481 ttccagatta ttcaaagtat caggatgggc atgtgaagtg actgacctta agatgtttcc
      541 attctcctgt gaattttaac ttgaactcat tcctgatgtt tgataccctg gttgaaaaca
      601 attcagtaaa gcatcctgcc tcagaatgac tttcctatca tgcttcatgt gtcattccaa
      661 ggtttcttca tgagtcattc caagttttct agtccatacc acagtgcctt gcaaaaaaca
      721 ccacatgaat aaagcaataa aatttgattg ttaagataca gtagtggacc ctacttattc
      781 agtcaattaa gagtaagttt ttttatgtgg ttattaaaac agtatgaaca attagtctaa
      841 ctctgcatag acagggtcta gattttgtta acccaaatgt ataactgcag ttagcttaaa
      901 ttacaatttg aagtcttgtg gtttttatat agctaggcac tttattactc ttttgaactg
      961 aaagcacact cccttatagg ttcatgtaac tgtcctgtaa taaggtgctt ataaatggaa
     1021 caactacaca gcctagtttt gccacaacct ttagcatcta aaaagtttta aaagcttcta
     1081 aatgtctaat ataaagggag atgcttatag ccacaacatc tattttacca atattgtttc
     1141 cattacacta ccttggattt tgcatgagtg agtatagtaa cccaagatgc cataaaaaaa
     1201 aacttgatcg ttttctgact taattagtta ctgtggtttc actaaaagct accgtggtgg
     1261 agtgaagtca gtcagggaag gtttgtttat gttacattta tttcaccaga actattttaa
     1321 tatatcaaag gggtttacta tgccaaacaa aattctaggg aaaaatactg ctaaaaatgg
     1381 atgcctcatc agaacatgct gttgagtcca atgtgccata agacatttta gcatgttaaa
     1441 tagcactttt aatagcaaaa aaaggcacat caactgcgaa gttatcctta gtttgcaaat
     1501 gctttttcta gattaatgat ttttcaatca ttagggtact agacacatca gcctaaagtg
     1561 gcatctggaa ttgaatggat ttactgataa tgatcagtct ttagtcttcc ctttgttata
     1621 tgactttata ggttatgatt gatcaaattt acgttttact aatggtaagg gtgagggtca
     1681 tagggcaggt tttgggtttt ctagtactgt tgaaaactgc aagtattggc tatttgtata
     1741 cttagccata acttggtgaa aaaaaacctg agcagtgtct atgtattaat gcgttggaaa
     1801 gaaagctgct tgtgtttgct ttgttaattg cctcaggata tttcttttaa aataagctgt
     1861 tttaagagga acagaaggga aatctgctac ctagtctata cacagcgtga acctcacagg
     1921 gggcttctga taccctcaaa catggagaac agtaagggag cagagtggtt aaggactttc
     1981 aggaacttaa ctattctgga ataaggaatg aatcaactga ccttgggcca gcaggttttt
     2041 aactaaattg ttacttgcct ttctcaccca gttaatcagt ctctgtactt gtttcccttt
     2101 ttgaaacaag tgtcttggtt aactaattct gttttatggt tgtgctaaat tcatagcagg
     2161 tgccttattc tttgctttta gtcaaaccat tccatatcag aattttcctt ggtttactat
     2221 agatatttgg ctttaagttg ttgtttgtgt tttttaatgt acaatgttct gataaatttg
     2281 actgttaaat tgctatagct agcaatcatt ttacatatgt aaaaaattgc attccctttg
     2341 tatttcatgt gtaattcacc aattaagtgc agtttatatt caggttggat tatgcatgtt
     2401 taggtaaacg aaagctgtgt cttacttgat ttattcttta aaaataaagt tccctgaata
     2461 tttgaaaaaa aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_014447               1234 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens ADP-ribosylation factor interacting protein 1
            (arfaptin 1) (ARFIP1), mRNA.
ACCESSION   NM_014447
VERSION     NM_014447.1  GI:7657209
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Ho,W.T., Exton,J.H. and Williger,B.T.
  TITLE     Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix
            metalloproteinase-9 secretion induced by phorbol ester in HT 1080
            fibrosarcoma cells
  JOURNAL   FEBS Lett. 537 (1-3), 91-95 (2003)
   PUBMED   12606037
  REMARK    GeneRIF: inhibits ADP-ribosylation factor-dependent matrix
            metalloproteinase-9 secretion induced by phorbol ester in
            fibrosarcoma cells
REFERENCE   2  (bases 1 to 1234)
  AUTHORS   Williger,B.T., Provost,J.J., Ho,W.T., Milstine,J. and Exton,J.H.
  TITLE     Arfaptin 1 forms a complex with ADP-ribosylation factor and
            inhibits phospholipase D
  JOURNAL   FEBS Lett. 454 (1-2), 85-89 (1999)
   PUBMED   10413101
REFERENCE   3  (bases 1 to 1234)
  AUTHORS   Kanoh,H., Williger,B.T. and Exton,J.H.
  TITLE     Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation
            factor, is recruited to Golgi membranes
  JOURNAL   J. Biol. Chem. 272 (9), 5421-5429 (1997)
   PUBMED   9038142
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U52521.1.
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..1234
                     /gene="ARFIP1"
                     /note="synonym: HSU52521"
                     /db_xref="GeneID:27236"
                     /db_xref="MIM:605928"
     CDS             131..1156
                     /gene="ARFIP1"
                     /note="arfaptin 1;
                     go_component: Golgi membrane [goid 0000139] [evidence IDA]
                     [pmid 9038142];
                     go_function: molecular_function unknown [goid 0005554]
                     [evidence ND];
                     go_process: biological_process unknown [goid 0000004]
                     [evidence ND]"
                     /codon_start=1
                     /product="ADP-ribosylation factor interacting protein 1
                     (arfaptin 1)"
                     /protein_id="NP_055262.1"
                     /db_xref="GI:7657210"
                     /db_xref="GeneID:27236"
                     /db_xref="MIM:605928"
                     /translation="MAQESPKNSAAEIPVTSNGEVDDSREHSFNRDLKHSLPSGLGLS
                     ETQITSHGFDNTKEGVIEAGAFQGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLN
                     TYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHT
                     QRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTI
                     EDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMR
                     NDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDA
                     PSWLEEQ"
ORIGIN      
        1 cgctgctctt ggttctggtt ctggaggctg ggttgagagg tcgccggtcc gactgtcctc
       61 ggcggttggt cagtgtgaat ttgtgacagc tgcagttgct ccccgccccc gagcagccga
      121 ggagtctacc atggctcaag aatctcccaa aaattcagca gcagaaattc cagtgactag
      181 taatggagaa gttgatgact ctcgtgaaca tagctttaat agggatttga agcattcatt
      241 accatctgga cttggtctct cagaaaccca aattacatct catggctttg acaataccaa
      301 agagggtgtt attgaagcag gagcatttca aggtggccag agaacacaga caaaaagtgg
      361 accagttatt ctagcagatg aaattaaaaa tcctgcaatg gaaaagttag aacttgttag
      421 aaaatggagt ctaaacacct ataagtgtac tcgacagatt atctctgaga agctaggccg
      481 tggctcaaga actgtggacc ttgaacttga agctcagatt gatatattaa gggataacaa
      541 gaaaaaatat gaaaatattt taaaactggc tcaaacattg tcgacccagc ttttccagat
      601 ggtacatacc caaaggcaac ttggagatgc atttgctgac ctgagtttga agtcactaga
      661 acttcatgaa gaatttggct ataatgccga tacccagaaa ctgctggcta aaaatggaga
      721 gactcttctt ggggccatta attttttcat tgctagtgtg aacactttgg tgaataaaac
      781 cattgaagat acattaatga ctgtgaaaca gtatgaaagt gccaggattg aatatgatgc
      841 atatcgcact gatttggaag aactgaatct tggaccacgt gacgcaaaca ctctgccaaa
      901 gattgagcag tcacagcatc tcttccaagc acataaggaa aaatatgata aaatgcgcaa
      961 tgatgtttct gtcaaattga aatttctaga agaaaataag gttaaagtat tgcacaatca
     1021 gctggtcctt ttccacaatg ccattgccgc ttactttgct gggaatcaga agcagcttga
     1081 acagacactt aaacagttcc atatcaaatt gaaaacccct ggagtggatg ccccatcttg
     1141 gcttgaagaa cagtaaaatc acagcggaaa ataaaaagaa agtcgcgttg ttatatttct
     1201 aaaccaacct aacaagaatt aagcagagtt gggc
//

LOCUS       NM_014452               3662 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens tumor necrosis factor receptor superfamily, member 21
            (TNFRSF21), mRNA.
ACCESSION   NM_014452 NM_016629
VERSION     NM_014452.3  GI:23238206
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
  MEDLINE   22887296
   PUBMED   12975309
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Zhao,H., Yan,M., Wang,H., Erickson,S., Grewal,I.S. and Dixit,V.M.
  TITLE     Impaired c-Jun amino terminal kinase activity and T cell
            differentiation in death receptor 6-deficient mice
  JOURNAL   J. Exp. Med. 194 (10), 1441-1448 (2001)
  MEDLINE   21571606
   PUBMED   11714751
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Liu,J., Na,S., Glasebrook,A., Fox,N., Solenberg,P.J., Zhang,Q.,
            Song,H.Y. and Yang,D.D.
  TITLE     Enhanced CD4+ T cell proliferation and Th2 cytokine production in
            DR6-deficient mice
  JOURNAL   Immunity 15 (1), 23-34 (2001)
  MEDLINE   21378416
   PUBMED   11485735
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Pan,G., Bauer,J.H., Haridas,V., Wang,S., Liu,D., Yu,G., Vincenz,C.,
            Aggarwal,B.B., Ni,J. and Dixit,V.M.
  TITLE     Identification and functional characterization of DR6, a novel
            death domain-containing TNF receptor
  JOURNAL   FEBS Lett. 431 (3), 351-356 (1998)
  MEDLINE   98378343
   PUBMED   9714541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017730.2, AK001504.1 and
            BI561782.1.
            On or before Nov 4, 2002 this sequence version replaced
            gi:21359912, gi:19923409.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor has been shown to activate
            NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its
            death domain, this receptor interacts with TRADD protein, which is
            known to serve as an adaptor that mediates signal transduction of
            TNF-receptors. Knockout studies in mice suggested that this gene
            plays a role in T-helper cell activation, and may be involved in
            inflammation and immune regulation.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1-12.2"
     gene            1..3662
                     /gene="TNFRSF21"
                     /note="synonyms: DR6, BM-018"
                     /db_xref="GeneID:27242"
                     /db_xref="MIM:605732"
     CDS             434..2401
                     /gene="TNFRSF21"
                     /note="death receptor 6; TNFR-related death receptor 6;
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: receptor activity [goid 0004872] [evidence
                     IEA];
                     go_process: apoptosis [goid 0006915] [evidence IEA];
                     go_process: signal transduction [goid 0007165] [evidence
                     IEA]"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily,
                     member 21 precursor"
                     /protein_id="NP_055267.1"
                     /db_xref="GI:7657039"
                     /db_xref="GeneID:27242"
                     /db_xref="MIM:605732"
                     /translation="MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPE
                     QKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENG
                     IEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKG
                     TETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFS
                     SSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVP
                     DNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRG
                     HPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKA
                     GLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSN
                     GYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDK
                     LALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSG
                     SSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDK
                     LDRLFEIIGVKSQEASQTLLDSVYSHLPDLL"
     sig_peptide     434..556
                     /gene="TNFRSF21"
     mat_peptide     557..2398
                     /gene="TNFRSF21"
                     /product="tumor necrosis factor receptor superfamily,
                     member 21"
     polyA_signal    3613..3618
                     /gene="TNFRSF21"
     polyA_site      3634
                     /gene="TNFRSF21"
                     /evidence=experimental
ORIGIN      
        1 gccaccacgt gtgtccctgc gcccggtggc caccgactca gtccctcgcc gaccagtctg
       61 ggcagcggag gagggtggtt ggcagtggct ggaagcttcg ctatgggaag ttgttccttt
      121 gctctctcgc gcccagtcct cctccctggt tctcctcagc cgctgtcgga ggagagcacc
      181 cggagacgcg ggctgcagtc gcggcggctt ctccccgcct gggcggccgc gccgctgggc
      241 aggtgctgag cgcccctaga gcctcccttg ccgcctccct cctctgcccg gccgcagcag
      301 tgcacatggg gtgttggagg tagatgggct cccggcccgg gaggcggcgg tggatgcggc
      361 gctgggcaga agcagccgcc gattccagct gccccgcgcg ccccgggcgc ccctgcgagt
      421 ccccggttca gccatgggga cctctccgag cagcagcacc gccctcgcct cctgcagccg
      481 catcgcccgc cgagccacag ccacgatgat cgcgggctcc cttctcctgc ttggattcct
      541 tagcaccacc acagctcagc cagaacagaa ggcctcgaat ctcattggca cataccgcca
      601 tgttgaccgt gccaccggcc aggtgctaac ctgtgacaag tgtccagcag gaacctatgt
      661 ctctgagcat tgtaccaaca caagcctgcg cgtctgcagc agttgccctg tggggacctt
      721 taccaggcat gagaatggca tagagaaatg ccatgactgt agtcagccat gcccatggcc
      781 aatgattgag aaattacctt gtgctgcctt gactgaccga gaatgcactt gcccacctgg
      841 catgttccag tctaacgcta cctgtgcccc ccatacggtg tgtcctgtgg gttggggtgt
      901 gcggaagaaa gggacagaga ctgaggatgt gcggtgtaag cagtgtgctc ggggtacctt
      961 ctcagatgtg ccttctagtg tgatgaaatg caaagcatac acagactgtc tgagtcagaa
     1021 cctggtggtg atcaagccgg ggaccaagga gacagacaac gtctgtggca cactcccgtc
     1081 cttctccagc tccacctcac cttcccctgg cacagccatc tttccacgcc ctgagcacat
     1141 ggaaacccat gaagtccctt cctccactta tgttcccaaa ggcatgaact caacagaatc
     1201 caactcttct gcctctgtta gaccaaaggt actgagtagc atccaggaag ggacagtccc
     1261 tgacaacaca agctcagcaa gggggaagga agacgtgaac aagaccctcc caaaccttca
     1321 ggtagtcaac caccagcaag gcccccacca cagacacatc ctgaagctgc tgccgtccat
     1381 ggaggccact gggggcgaga agtccagcac gcccatcaag ggccccaaga ggggacatcc
     1441 tagacagaac ctacacaagc attttgacat caatgagcat ttgccctgga tgattgtgct
     1501 tttcctgctg ctggtgcttg tggtgattgt ggtgtgcagt atccggaaaa gctcgaggac
     1561 tctgaaaaag gggccccggc aggatcccag tgccattgtg gaaaaggcag ggctgaagaa
     1621 atccatgact ccaacccaga accgggagaa atggatctac tactgcaatg gccatggtat
     1681 cgatatcctg aagcttgtag cagcccaagt gggaagccag tggaaagata tctatcagtt
     1741 tctttgcaat gccagtgaga gggaggttgc tgctttctcc aatgggtaca cagccgacca
     1801 cgagcgggcc tacgcagctc tgcagcactg gaccatccgg ggccccgagg ccagcctcgc
     1861 ccagctaatt agcgccctgc gccagcaccg gagaaacgat gttgtggaga agattcgtgg
     1921 gctgatggaa gacaccaccc agctggaaac tgacaaacta gctctcccga tgagccccag
     1981 cccgcttagc ccgagcccca tccccagccc caacgcgaaa cttgagaatt ccgctctcct
     2041 gacggtggag ccttccccac aggacaagaa caagggcttc ttcgtggatg agtcggagcc
     2101 ccttctccgc tgtgactcta catccagcgg ctcctccgcg ctgagcagga acggttcctt
     2161 tattaccaaa gaaaagaagg acacagtgtt gcggcaggta cgcctggacc cctgtgactt
     2221 gcagcctatc tttgatgaca tgctccactt tctaaatcct gaggagctgc gggtgattga
     2281 agagattccc caggctgagg acaaactaga ccggctattc gaaattattg gagtcaagag
     2341 ccaggaagcc agccagaccc tcctggactc tgtttatagc catcttcctg acctgctgta
     2401 gaacataggg atactgcatt ctggaaatta ctcaatttag tggcagggtg gttttttaat
     2461 tttcttctgt ttctgatttt tgttgtttgg ggtgtgtgtg tgtgtttgtg tgtgtgtgtg
     2521 tgtgtgtgtg tgtgtgtgtg tttaacagag aatatggcca gtgcttgagt tctttctcct
     2581 tctctctctc tctttttttt ttaaataact cttctgggaa gttggtttat aagcctttgc
     2641 caggtgtaac tgttgtgaaa tacccaccac taaagttttt taagttccat attttctcca
     2701 ttttgccttc ttatgtattt tcaagattat tctgtgcact ttaaatttac ttaacttacc
     2761 ataaatgcag tgtgactttt cccacacact ggattgtgag gctcttaact tcttaaaagt
     2821 ataatggcat cttgtgaatc ctataagcag tctttatgtc tcttaacatt cacacctact
     2881 ttttaaaaac aaatattatt actattttta ttattgtttg tcctttataa attttcttaa
     2941 agattaagaa aatttaagac cccattgagt tactgtaatg caattcaact ttgagttatc
     3001 ttttaaatat gtcttgtata gttcatattc atggctgaaa cttgaccaca ctattgctga
     3061 ttgtatggtt ttcacctgga caccgtgtag aatgcttgat tacttgtact cttcttatgc
     3121 taatatgctc tgggctggag aaatgaaatc ctcaagccat caggatttgc tatttaagtg
     3181 gcttgacaac tgggccacca aagaacttga acttcacctt ttaggatttg agctgttctg
     3241 gaacacattg ctgcactttg gaaagtcaaa atcaagtgcc agtggcgccc tttccataga
     3301 gaatttgccc agctttgctt taaaagatgt cttgtttttt atatacacat aatcaatagg
     3361 tccaatctgc tctcaaggcc ttggtcctgg tgggattcct tcaccaatta ctttaattaa
     3421 aaatggctgc aactgtaaga acccttgtct gatatatttg caactatgct cccatttaca
     3481 aatgtacctt ctaatgctca gttgccaggt tccaatgcaa aggtggcgtg gactcccttt
     3541 gtgtgggtgg ggtttgtggg tagtggtgaa ggaccgatat cagaaaaatg ccttcaagtg
     3601 tactaattta ttaataaaca ttaggtgttt gttaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3661 aa
//

LOCUS       NM_014481               1991 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens APEX nuclease (apurinic/apyrimidinic endonuclease) 2
            (APEX2), nuclear gene encoding mitochondrial protein, mRNA.
ACCESSION   NM_014481
VERSION     NM_014481.2  GI:18375506
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Hadi,M.Z., Ginalski,K., Nguyen,L.H. and Wilson,D.M. III.
  TITLE     Determinants in nuclease specificity of Ape1 and Ape2, human
            homologues of Escherichia coli exonuclease III
  JOURNAL   J. Mol. Biol. 316 (3), 853-866 (2002)
   PUBMED   11866537
  REMARK    GeneRIF: Determinants in nuclease specificity of Ape1 and Ape2,
            human homologues of Escherichia coli exonuclease III
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Tsuchimoto,D., Sakai,Y., Sakumi,K., Nishioka,K., Sasaki,M.,
            Fujiwara,T. and Nakabeppu,Y.
  TITLE     Human APE2 protein is mostly localized in the nuclei and to some
            extent in the mitochondria, while nuclear APE2 is partly associated
            with proliferating cell nuclear antigen
  JOURNAL   Nucleic Acids Res. 29 (11), 2349-2360 (2001)
   PUBMED   11376153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF119046.1, AB049211.1 and
            BI837686.1.
            On Jan 25, 2002 this sequence version replaced gi:7656891.
            
            Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA
            molecules by spontaneous hydrolysis, by DNA damaging agents or by
            DNA glycosylases that remove specific abnormal bases. AP sites are
            pre-mutagenic lesions that can prevent normal DNA replication so
            the cell contains systems to identify and repair such sites. Class
            II AP endonucleases cleave the phosphodiester backbone 5' to the AP
            site. This gene encodes a protein shown to have a weak class II AP
            endonuclease activity. Most of the encoded protein is located in
            the nucleus but some is also present in mitochondria. This protein
            may play an important role in both nuclear and mitochondrial base
            excision repair (BER).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..1991
                     /gene="APEX2"
                     /note="synonyms: APE2, XTH2, APEXL2"
                     /db_xref="GeneID:27301"
     CDS             77..1633
                     /gene="APEX2"
                     /note="apurinic/apyrimidinic endonuclease-like 2; APEX
                     nuclease-like 2;
                     go_function: endonuclease activity [goid 0004519]
                     [evidence IEA];
                     go_process: DNA repair [goid 0006281] [evidence IEA]"
                     /codon_start=1
                     /product="apurinic/apyrimidinic endonuclease 2"
                     /protein_id="NP_055296.2"
                     /db_xref="GI:18375507"
                     /db_xref="GeneID:27301"
                     /translation="MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIV
                     CLQETKVTRDALTEPLAIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGL
                     FATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHA
                     DPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEE
                     DPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRL
                     DYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAG
                     TQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKN
                     LKSYFQPSPSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVKGQAKTSEAKDEKE
                     LRTSFWKSVLAGPLRTPLCGGHREPCVMRTVKKPGPNLGRRFYMCARPRGPPTDPSSR
                     CNFFLWSRPS"
     polyA_signal    1946..1951
                     /gene="APEX2"
     polyA_site      1966
                     /gene="APEX2"
                     /evidence=experimental
     polyA_site      1976
                     /gene="APEX2"
                     /evidence=experimental
ORIGIN      
        1 tggccaactt ctgaacagga agcagttcgc tcgcgcctag gttggcgcgg gctgggaggt
       61 gttccagccc tttaagatgt tgcgcgtggt gagctggaac atcaatggga ttcggagacc
      121 cctgcaaggg gtggcaaatc aggaacccag caactgtgcc gccgtggccg tggggcgcat
      181 tttggacgag ctggatgcgg atatcgtctg tctccaggaa accaaagtga ccagggatgc
      241 actgacagag cccctggcta tcgttgaggg ttataactcc tatttcagct tcagccgcaa
      301 ccgtagcggc tattctggtg tagccacctt ctgtaaggac aatgctaccc cagtggctgc
      361 tgaagaaggc ctgagtggcc tgtttgccac ccagaatggg gatgttggtt gctatggaaa
      421 catggatgag tttacccaag aggaactccg ggctctggat agtgagggca gggccctcct
      481 cacacagcat aagatccgca catgggaagg taaggagaag accttgaccc taatcaacgt
      541 gtactgcccc catgcggacc ctgggaggcc tgagcggcta gtctttaaga tgcgcttcta
      601 tcgtttgctg caaatccgag cagaagccct cctggcggca ggcagccatg tgatcattct
      661 gggtgacctg aatacagccc accgccccat tgaccactgg gatgcagtca acctggaatg
      721 ctttgaagag gacccagggc gcaagtggat ggacagcttg ctcagtaact tggggtgcca
      781 gtctgcctct catgtagggc ccttcatcga tagctaccgc tgcttccaac caaagcagga
      841 gggggccttc acctgctggt cagcagtcac tggcgcccgc catctcaact atggctcccg
      901 gcttgactat gtgctggggg acaggaccct ggtcatagac acctttcagg cctctttcct
      961 gctgcctgag gtgatgggct ctgaccactg ccctgtgggt gcagtcttga gtgtgtcctc
     1021 tgtgcctgca aaacagtgcc cacctctgtg cacccgcttc ctccctgagt ttgcaggcac
     1081 ccagctcaag atccttcgct tcctagttcc tctcgaacaa agtcctgtgt tggagcagtc
     1141 gacgctgcag cacaacaatc aaacccgggt acagacatgc caaaacaaag cccaagtgcg
     1201 ctcaaccagg cctcagccca gtcaggttgg ctctagcaga ggccagaaaa acctgaagag
     1261 ctactttcag ccctccccta gctgtcccca agcctctcct gacatagagc tgcctagcct
     1321 accactgatg agcgccctca tgaccccgaa gactccagaa gagaaggcag tggccaaagt
     1381 ggtgaagggg caggccaaga cttcagaagc caaagatgag aaggagttac ggacctcatt
     1441 ctggaagtct gtgctggcgg ggcccttgcg cacacccctc tgtgggggcc acagggagcc
     1501 atgtgtgatg cgtactgtga agaagccagg acccaacttg ggccgccgct tctacatgtg
     1561 tgccaggccc cggggtcctc ccactgaccc ctcctcccgg tgcaacttct tcctctggag
     1621 caggcccagc tgaaccaatg gaggcctggg gacatctggc atggtcaccc ctgcacatga
     1681 tctgaggcca gctccccttc cctgagctgc ctcctgcttc tccctcaaag tctcctaccc
     1741 ttctcttcct cttttaagcc ctctcttcct cgctttcctt cctacctagc tccttgttgg
     1801 tgagcttctt gtgccttaat cctgtgaccc agccccttac accactttcc accttcctgt
     1861 ccgaagtaca cggacactag ctgccccagg aagttgtgtg attttaaatc acttctgtct
     1921 ttgctggaaa gtgtatttgt gcataaataa agtctgtgta tttgtttcag ggttgcaaaa
     1981 aaaaaaaaaa a
//

LOCUS       NM_014762               4288 bp    mRNA    linear   PRI 03-FEB-2005
DEFINITION  Homo sapiens 24-dehydrocholesterol reductase (DHCR24), mRNA.
ACCESSION   NM_014762
VERSION     NM_014762.2  GI:56790943
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Wu,C., Miloslavskaya,I., Demontis,S., Maestro,R. and Galaktionov,K.
  TITLE     Regulation of cellular response to oncogenic and oxidative stress
            by Seladin-1
  JOURNAL   Nature 432 (7017), 640-645 (2004)
   PUBMED   15577914
  REMARK    GeneRIF: unanticipated role for Seladin-1, previously implicated in
            Alzheimer's disease and cholesterol metabolism, in integrating
            cellular response to oncogenic and oxidative stress
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   Luciani,P., Ferruzzi,P., Arnaldi,G., Crescioli,C., Benvenuti,S.,
            Nesi,G., Valeri,A., Greeve,I., Serio,M., Mannelli,M. and Peri,A.
  TITLE     Expression of the novel adrenocorticotropin-responsive gene
            selective Alzheimer's disease indicator-1 in the normal adrenal
            cortex and in adrenocortical adenomas and carcinomas
  JOURNAL   J. Clin. Endocrinol. Metab. 89 (3), 1332-1339 (2004)
   PUBMED   15001630
  REMARK    GeneRIF: seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven
            pathway and its expression is reduced in adrenal cancer
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Andersson,H.C., Kratz,L. and Kelley,R.
  TITLE     Desmosterolosis presenting with multiple congenital anomalies and
            profound developmental delay
  JOURNAL   Am. J. Med. Genet. 113 (4), 315-319 (2002)
  MEDLINE   22343968
   PUBMED   12457401
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Waterham,H.R., Koster,J., Romeijn,G.J., Hennekam,R.C., Vreken,P.,
            Andersson,H.C., FitzPatrick,D.R., Kelley,R.I. and Wanders,R.J.
  TITLE     Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause
            desmosterolosis, an autosomal recessive disorder of cholesterol
            biosynthesis
  JOURNAL   Am. J. Hum. Genet. 69 (4), 685-694 (2001)
  MEDLINE   21426336
   PUBMED   11519011
REFERENCE   5  (bases 1 to 4288)
  AUTHORS   Greeve,I., Hermans-Borgmeyer,I., Brellinger,C., Kasper,D.,
            Gomez-Isla,T., Behl,C., Levkau,B. and Nitsch,R.M.
  TITLE     The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to
            Alzheimer's disease-associated neurodegeneration and oxidative
            stress
  JOURNAL   J. Neurosci. 20 (19), 7345-7352 (2000)
  MEDLINE   20482303
   PUBMED   11007892
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ439951.1, BC004375.1,
            D13643.3, BC011669.2 and AI952034.1.
            On Dec 23, 2004 this sequence version replaced gi:13375617.
            
            Summary: This gene encodes a flavin adenine dinucleotide
            (FAD)-dependent oxidoreductase which catalyzes the reduction of the
            delta-24 double bond of sterol intermediates during cholesterol
            biosynthesis. The protein contains a leader sequence that directs
            it to the endoplasmic reticulum membrane. Missense mutations in
            this gene have been associated with desmosterolosis. Also, reduced
            expression of the gene occurs in the temporal cortex of Alzheimer
            disease patients and overexpression has been observed in adrenal
            gland cancer cells.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33-p31.1"
     gene            1..4288
                     /gene="DHCR24"
                     /note="synonyms: KIAA0018, SELADIN1"
                     /db_xref="GeneID:1718"
                     /db_xref="MIM:606418"
     CDS             114..1664
                     /gene="DHCR24"
                     /EC_number="1.3.1.-"
                     /note="diminuto/dwarf1 homolog; selective AD indicator 1;
                     3 beta-hydroxysterol delta 24-reductase;
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence IEA];
                     go_function: oxidoreductase activity [goid 0016491]
                     [evidence IEA];
                     go_process: electron transport [goid 0006118] [evidence
                     IEA];
                     go_process: cholesterol biosynthesis [goid 0006695]
                     [evidence IEA]"
                     /codon_start=1
                     /product="24-dehydrocholesterol reductase precursor"
                     /protein_id="NP_055577.1"
                     /db_xref="GI:13375618"
                     /db_xref="GeneID:1718"
                     /db_xref="MIM:606418"
                     /translation="MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSL
                     IFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSL
                     RVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELD
                     DLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSC
                     GTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDE
                     AVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRS
                     IFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMK
                     CLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEA
                     RSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYD
                     KICKAARH"
     sig_peptide     114..173
                     /gene="DHCR24"
     mat_peptide     174..1661
                     /gene="DHCR24"
                     /product="24-dehydrocholesterol reductase"
     polyA_signal    4247..4252
                     /gene="DHCR24"
     polyA_site      4270
                     /gene="DHCR24"
ORIGIN      
        1 gcgatcccgg gctccccggg ctgtgggcta caggcgcaga gcgggccagg cgcggagctg
       61 gcggcagtga caggaggcgc gaacccgcag cgcttaccgc gcggcgccgc accatggagc
      121 ccgccgtgtc gctggccgtg tgcgcgctgc tcttcctgct gtgggtgcgc ctgaaggggc
      181 tggagttcgt gctcatccac cagcgctggg tgttcgtgtg cctcttcctc ctgccgctct
      241 cgcttatctt cgatatctac tactacgtgc gcgcctgggt ggtgttcaag ctcagcagcg
      301 ctccgcgcct gcacgagcag cgcgtgcggg acatccagaa gcaggtgcgg gaatggaagg
      361 agcagggtag caagaccttc atgtgcacgg ggcgccctgg ctggctcact gtctcactac
      421 gtgtcgggaa gtacaagaag acacacaaaa acatcatgat caacctgatg gacattctgg
      481 aagtggacac caagaaacag attgtccgtg tggagccctt ggtgaccatg ggccaggtga
      541 ctgccctgct gacctccatt ggctggactc tccccgtgtt gcctgagctt gatgacctca
      601 cagtgggggg cttgatcatg ggcacaggca tcgagtcatc atcccacaag tacggcctgt
      661 tccaacacat ctgcactgct tacgagctgg tcctggctga tggcagcttt gtgcgatgca
      721 ctccgtccga aaactcagac ctgttctatg ccgtaccctg gtcctgtggg acgctgggtt
      781 tcctggtggc cgctgagatc cgcatcatcc ctgccaagaa gtacgtcaag ctgcgtttcg
      841 agccagtgcg gggcctggag gctatctgtg ccaagttcac ccacgagtcc cagcggcagg
      901 agaaccactt cgtggaaggg ctgctctact ccctggatga ggctgtcatt atgacagggg
      961 tcatgacaga tgaggcagag cccagcaagc tgaatagcat tggcaattac tacaagccgt
     1021 ggttctttaa gcatgtggag aactatctga agacaaaccg agagggcctg gagtacattc
     1081 ccttgagaca ctactaccac cgccacacgc gcagcatctt ctgggagctc caggacatta
     1141 tcccctttgg caacaacccc atcttccgct acctctttgg ctggatggtg cctcccaaga
     1201 tctccctcct gaagctgacc cagggtgaga ccctgcgcaa gctgtacgag cagcaccacg
     1261 tggtgcagga catgctggtg cccatgaagt gcctgcagca ggccctgcac accttccaaa
     1321 acgacatcca cgtctacccc atctggctgt gtccgttcat cctgcccagc cagccaggcc
     1381 tagtgcaccc caaaggaaat gaggcagagc tctacatcga cattggagca tatggggagc
     1441 cgcgtgtgaa acactttgaa gccaggtcct gcatgaggca gctggagaag tttgtccgca
     1501 gcgtgcatgg cttccagatg ctgtatgccg actgctacat gaaccgggag gagttctggg
     1561 agatgtttga tggctccttg taccacaagc tgcgagagaa gctgggttgc caggacgcct
     1621 tccccgaggt gtacgacaag atctgcaagg ccgccaggca ctgagctgga gcccgcctgg
     1681 agagacagac acgtgtgagt ggtcaggcat cttcccttca ctcaagcttg gctgctttcc
     1741 tagatccaca ctttcaaaga gaaacccctc cagaactccc accctgacag cccaacacca
     1801 ccttcctcct ggcttccagg gggcagccca gtggaatgga aagaatgtgg gatttggagt
     1861 cagacaagcc tgagtccagt tccccgttta gaactcatta gctgtgtgac tctgggtgag
     1921 tcccttaacc cctctgagcc cgggtctctt cattagttga aagggatagt aatacctact
     1981 tgcaggttgt tgtcatctga gttgagcact ggtcacattg aaggtgctgg gtaagtggta
     2041 gctcttgttg cttcccgttc agcgtcacat ctgcagtgga gcctgaaaag gctccacatt
     2101 aggtcacctg tgcacagcca tggctggaat gatgaagggg atacgctgga gttgccctgc
     2161 catcgcctcc atcagccaga cgaggtcctc acaggagaag gacagctctt ccccaccctg
     2221 ggatctcagg agggcagcca cggagtgggg aggccccaga tgcgctgtgc caaagccagg
     2281 tccgaggcca aagttctccc tgccatcctt ggtgccgtcc tgccccttcc tccttcatgc
     2341 ctgggcctgc aggcccaccc cagccaccac tgagtccact cggagtgccc tgtgttcctg
     2401 gagaaggcat tccagggttg aatcttgtcc cagcctcagc ctgggacacc taggtggaga
     2461 gagtggtctc cgctctgaat tggatccagg ggacctgggc tcattcttct tggctcacca
     2521 accctgcagg cctcatcttt cccaaaaccc actttgtctt ggtgggagtg ggtccgcgct
     2581 gctctgcagc aggggctggg gagtggacag catcaggtgg gaaagtggag tccaccctca
     2641 tgtttctgta ggattctcac cgtggggctg gaagaaaaga gcatcgactt gatttctcca
     2701 accactcatc cctctttttc tttcttccac cactccccac cccagctgta gttaatttca
     2761 gtgccttaca aatcctaagc tcagagaaag ttccatttcc gttccagagg gaagggaacc
     2821 tccctaggtc cttccctggc ttgttataac gcaaagcttg gttgtttatg caactctatc
     2881 ttaagaactg cccagcctca gctgaaaacc cgaatctgag aaggaattgc gtcatgtaag
     2941 ggaagctgga attaagggag ctgagccagt catggttgtg gcgtgtgagt caggagacct
     3001 aggtttcagc ccctctctac tgtcagcgag ctgtgcaacg tgggcaagtc attgtcctct
     3061 gagctgcagt ttcctcatct gtcacatcgc tacagacaag acctccctgg aacccttctg
     3121 attgtcttag acactgtggt tgcaaaaccc acggaaagcc tcatttgtgt ggaaagtcag
     3181 aggaaaaatg atccagtgga cacttgggga ttatctgtca ttcaagatcc ttccttcaac
     3241 cccaaggtca gctcccatct catttccaga aaggctcata cctggcttgc agggaagcat
     3301 ctgtcttgtc attccaggtg ccagaatcct ctcagagtca ttgaagggtg ttcacccatc
     3361 ccacccaagg cttggcacac tgccagtgtc ttagcagggt cttgtgaggg ctgggggcat
     3421 ccaggcactc agaaggcaaa ggaaccaccc tacccatttg gcctctggag ggggcagaag
     3481 aaagaaagaa acctcatcct atattttaca aagcatgtga attctggcat tagctctcat
     3541 aggagaccca tgtgcttcct tgctcagtgc aaaactgatg attctacttg ctgtagatga
     3601 atggttaaca cgagctagtt aaacagtgcc attgttttgc cagtgaagcc tccaacccta
     3661 agccactggg acggtggcca gagatgccag cagcctctgt cgcccttagt catataacca
     3721 aaatccagac cttatccaca acccggggct tggaaaggaa ggtattttgg aatcacaccc
     3781 tccggttatg ttgctccagt aaaatcttgc ctggaaagag gcagtcttct tagcatggtg
     3841 agctgagttc atggcttttt tttgtagcca gtcctgtccc tggccatcca tgtgatggtt
     3901 ttggatggag ttaaacttga tgccagtggg cagtgcatgt ggaaagtatc agagtaaggc
     3961 tctcccctcc agagccctga gtttcttggc tgcatgaagg ttttctttag aatcagaatt
     4021 gtagccagtt tctttggcca gaaggatgaa tacttggata ttactgaaag ggaggggtgg
     4081 agatgggtgt ggcagtgtat ggtgtgtgat ttttattttc ttctttggtc atgggggcca
     4141 aggagaaagg catgaatctt ccctgtcagg ctcttacagc cacaggcact gtgtctactg
     4201 tctggaagac atgtccccgt ggctgtgggg ccgctgcttc tgtttaaata aaagtggcct
     4261 ggaagctggc aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_014918               4620 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens carbohydrate (chondroitin) synthase 1 (CHSY1), mRNA.
ACCESSION   NM_014918
VERSION     NM_014918.3  GI:37537719
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4620)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
REFERENCE   2  (bases 1 to 4620)
  AUTHORS   Kitagawa,H., Izumikawa,T., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning of a chondroitin polymerizing factor that
            cooperates with chondroitin synthase for chondroitin polymerization
  JOURNAL   J. Biol. Chem. 278 (26), 23666-23671 (2003)
   PUBMED   12716890
  REMARK    GeneRIF: chondroitin polymerizing activity requires concomitant
            expression of a ChPF with ChSy; coexpression of the ChPF and ChSy
            yielded markedly augmented glycosyltransferase activities, whereas
            simple mixing of the two separately expressed proteins did not.
REFERENCE   3  (bases 1 to 4620)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J. Biol. Chem. 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC046247.1.
            On Oct 7, 2003 this sequence version replaced gi:31542308.
            
            Summary: CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan
            expressed on the surface of most cells and in extracellular
            matrices. Glycosaminoglycan chains are covalently linked to a wide
            range of core protein families and regulate many biologic
            processes, including cell proliferation and recognition,
            extracellular matrix deposition, and morphogenesis.[supplied by
            OMIM].
FEATURES             Location/Qualifiers
     source          1..4620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..4620
                     /gene="CHSY1"
                     /note="synonym: KIAA0990"
                     /db_xref="GeneID:22856"
                     /db_xref="MIM:608183"
     CDS             484..2892
                     /gene="CHSY1"
                     /note="chondroitin synthase"
                     /codon_start=1
                     /product="carbohydrate (chondroitin) synthase 1"
                     /protein_id="NP_055733.2"
                     /db_xref="GI:31542309"
                     /db_xref="GeneID:22856"
                     /db_xref="MIM:608183"
                     /translation="MAARGRRAWLSVLLGLVLGFVLASRLVLPRASELKRAGPRRRAS
                     PEGCRSGQAAASQAGGARGDARGAQLWPPGSDPDGGPRDRNFLFVGVMTAQKYLQTRA
                     VAAYRTWSKTIPGKVQFFSSEGSDTSVPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHY
                     LDKYEWFMRADDDVYIKGDRLENFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENF
                     CMGGPGVIMSREVLRRMVPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQL
                     FYENYEQNKKGYIRDLHNSKIHQAITLHPNKNPPYQYRLHSYMLSRKISELRHRTIQL
                     HREIVLMSKYSNTEIHKEDLQLGIPPSFMRFQPRQREEILEWEFLTGKYLYSAVDGQP
                     PRRGMDSAQREALDDIVMQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILD
                     LLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFVEHEELDAQELAKRINQESGSLSFLS
                     NSLKKLVPFQLPGSKSEHKEPKDKKINILIPLSGRFDMFVRFMGNFEKTCLIPNQNVK
                     LVVLLFNSDSNPDKAKQVELMRDYRIKYPKADMQILPVSGEFSRALALEVGSSQFNNE
                     SLLFFCDVDLVFTTEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDNHFAFT
                     QKTGFWRNYGFGITCIYKGDLVRVGGFDVSIQGWGLEDVDLFNKVVQAGLKTFRSQEV
                     GVVHVHHPVFCDPNLDPKQYKMCLGSKASTYGSTQQLAEMWLEKNDPSYSKSSNNNGS
                     VRTA"
ORIGIN      
        1 ccggaggatg tgcagctgcg gcggcggcgc cggctacgaa gaggacgggg acaggcgccg
       61 tgcgaaccga gcccagccag ccggaggacg cgggcagggc gggacgggag cccggactcg
      121 tctgccgccg ccgtcgtcgc cgtcgtgccg gccccgcgtc cccgcgcgcg agcgggagga
      181 gccgccgcca cctcgcgccc gagccgccgc tagcgcgcgc cgggcatggt cccctcttaa
      241 aggcgcaggc cgcggcggcg ggggcgggcg tgcggaacaa agcgccggcg cggggcctgc
      301 gggcggctcg ggggccgcga tgggcgcggc gggcccgcgg cggcggcggc gctgcccggg
      361 ccgggcctcg cggcgctagg gcgggctggc ctccgcgggc gggggcagcg ggctgagggc
      421 gcgcggagcc tgcggcggcg gcggcggcgg cggcggcggc ccggcgggcg gagcggcgcg
      481 ggcatggccg cgcgcggccg gcgcgcctgg ctcagcgtgc tgctcgggct cgtcctgggc
      541 ttcgtgctgg cctcgcggct cgtcctgccc cgggcttccg agctgaagcg agcgggccca
      601 cggcgccgcg ccagccccga gggctgccgg tccgggcagg cggcggcttc ccaggccggc
      661 ggggcgcgcg gcgatgcgcg cggggcgcag ctctggccgc ccggctcgga cccagatggc
      721 ggcccgcgcg acaggaactt tctcttcgtg ggagtcatga ccgcccagaa atacctgcag
      781 actcgggccg tggccgccta cagaacatgg tccaagacaa ttcctgggaa agttcagttc
      841 ttctcaagtg agggttctga cacatctgta ccaattccag tagtgccact acggggtgtg
      901 gacgactcct acccgcccca gaagaagtcc ttcatgatgc tcaagtacat gcacgaccac
      961 tacttggaca agtatgaatg gtttatgaga gcagatgatg acgtgtacat caaaggagac
     1021 cgtctggaga acttcctgag gagtttgaac agcagcgagc ccctctttct tgggcagaca
     1081 ggcctgggca ccacggaaga aatgggaaaa ctggccctgg agcctggtga gaacttctgc
     1141 atgggggggc ctggcgtgat catgagccgg gaggtgcttc ggagaatggt gccgcacatt
     1201 ggcaagtgtc tccgggagat gtacaccacc catgaggacg tggaggtggg aaggtgtgtc
     1261 cggaggtttg caggggtgca gtgtgtctgg tcttatgaga tgcagcagct tttttatgag
     1321 aattacgagc agaacaaaaa ggggtacatt agagatctcc ataacagtaa aattcaccaa
     1381 gctatcacat tacaccccaa caaaaaccca ccctaccagt acaggctcca cagctacatg
     1441 ctgagccgca agatatccga gctccgccat cgcacaatac agctgcaccg cgaaattgtc
     1501 ctgatgagca aatacagcaa cacagaaatt cataaagagg acctccagct gggaatccct
     1561 ccctccttca tgaggtttca gccccgccag cgagaggaga ttctggaatg ggagtttctg
     1621 actggaaaat acttgtattc ggcagttgac ggccagcccc ctcgaagagg aatggactcc
     1681 gcccagaggg aagccttgga cgacattgtc atgcaggtca tggagatgat caatgccaac
     1741 gccaagacca gagggcgcat cattgacttc aaagagatcc agtacggcta ccgccgggtg
     1801 aaccccatgt atggggctga gtacatcctg gacctgctgc ttctgtacaa aaagcacaaa
     1861 gggaagaaaa tgacggtccc tgtgaggagg cacgcgtatt tacagcagac tttcagcaaa
     1921 atccagtttg tggagcatga ggagctggat gcacaagagt tggccaagag aatcaatcag
     1981 gaatctggat ccttgtcctt tctctcaaac tccctgaaga agctcgtccc ctttcagctc
     2041 cctgggtcga agagtgagca caaagaaccc aaagataaaa agataaacat actgattcct
     2101 ttgtctgggc gtttcgacat gtttgtgaga tttatgggaa actttgagaa gacgtgtctt
     2161 atccccaatc agaacgtcaa gctcgtggtt ctgcttttca attctgactc caaccctgac
     2221 aaggccaaac aagttgaact gatgagagat taccgcatta agtaccctaa agccgacatg
     2281 cagattttgc ctgtgtctgg agagttttca agagccctgg ccctggaagt aggatcctcc
     2341 cagtttaaca atgaatcttt gctcttcttc tgcgacgtcg acctcgtgtt tactacagaa
     2401 ttccttcagc gatgtcgagc aaatacagtt ctgggccaac aaatatattt tccaatcatc
     2461 ttcagccagt atgacccaaa gattgtttat agtgggaaag ttcccagtga caaccatttt
     2521 gcctttactc agaaaactgg cttctggaga aactatgggt ttggcatcac gtgtatttat
     2581 aagggagatc ttgtccgagt gggtggcttt gatgtttcca tccaaggctg ggggctggag
     2641 gatgtggacc ttttcaacaa ggttgtccag gcaggtttga agacgtttag gagccaggaa
     2701 gtaggagtag tccacgtcca ccatcctgtc ttttgtgatc ccaatcttga ccccaaacag
     2761 tacaaaatgt gcttggggtc caaagcatcg acctatgggt ccacacagca gctggctgag
     2821 atgtggctgg aaaaaaatga tccaagttac agtaaaagca gcaataataa tggctcagtg
     2881 aggacagcct aatgtccagc tttgctggaa aagacgtttt taattatcta atttattttt
     2941 caaaaatttt ttgtatgatc agtttttgaa gtccgtatac aaggatatat tttacaagtg
     3001 gttttcttac ataggactcc tttaagattg agctttctga acaagaaggt gatcagtgtt
     3061 tgcctttgaa cacatcttct tgctgaacat tatgtagcag acctgcttaa ctttgacttg
     3121 aaatgtacct gatgaacaaa acttttttaa aaaaatgttt tcttttgaga ccctttgctc
     3181 cagtcctatg gcagaaaacg tgaacattcc tgcaaagtat tattgtaaca aaacactgta
     3241 actctggtaa atgttctgtt gtgattgtta acattccaca gattctacct tttgtgtttt
     3301 gttttttttt tttacaattg ttttaaagcc atttcatgtt ccagttgtaa gataaggaaa
     3361 tgtgataata gctgtttcat cattgtcttc aggagagctt tccagagttg atcatttccc
     3421 ctcatggtac tctgctcagc atggccacgt aggttttttg tttgttttgt tttgttcttt
     3481 ttttgagacg gagtctcact ctgttaccca ggctggaatg cagtggcgca atcttggctc
     3541 actttaacct ccacttccct ggttcaagca attcccctgc ctttgcctcc cgagtagctg
     3601 ggattacagg cacacaccac cacgcccagc tagttttttt gtatttttag tagagacggg
     3661 gtttcaccat gcaagcccag ctggccacgt aggttttaaa gcaaggggcg tgaagaaggc
     3721 acagtgaggt atgtggctgt tctcgtggta gttcattcgg cctaaataga cctggcatta
     3781 aatttcaaga aggatttggc attttctctt cttgaccctt ctctttaaag ggtaaaatat
     3841 taatgtttag aatgacaaag atgaattatt acaataaatc tgatgtacac agactgaaac
     3901 acacacacat acaccctaat caaaacgttg gggaaaaatg tatttggttt tgttcctttc
     3961 atcctgtctg tgttatgtgg gtggagatgg ttttcattct ttcattactg ttttgtttta
     4021 tcctttgtat ctgaaatacc tttaatttat ttaatatctg ttgttcagag ctctgccatt
     4081 tcttgagtac ctgttagtta gtattattta tgtgtatcgg gagtgtgttt agtctgtttt
     4141 atttgcagta aaccgatctc caaagatttc cttttggaaa cgctttttcc cctccttaat
     4201 ttttatattc cttactgttt tactaaatat taagtgttct ttgacaattt tggtgctcat
     4261 gtgttttggg gacaaaagtg aaatgaatct gtcattatac cagaaagtta aattctcaga
     4321 tcaaatgtgc cttaataaat ttgttttcat ttagatttca aacagtgata gacttgccat
     4381 tttaatacac gtcattggag ggctgcgtat ttgtaaatag cctgatgctc atttggaaaa
     4441 ataaaccagt gaacaatatt tttctattgt acttttcgaa ccattttgtc tcattattcc
     4501 tgttttagct gaagaattgt attacatttg gagagtaaaa aacttaaaca cgaaaaaaaa
     4561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//

LOCUS       NM_015055               3719 bp    mRNA    linear   PRI 18-DEC-2004
DEFINITION  Homo sapiens SWAP-70 protein (SWAP70), mRNA.
ACCESSION   NM_015055
VERSION     NM_015055.1  GI:30911100
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Hilpel, Oberbanscheidt,P., Hahne,P., Hund,M., Kalhammer,G.,
            Small,J.V. and B.
  TITLE     SWAP-70 identifies a transitional subset of actin filaments in
            motile cells
  JOURNAL   Mol. Biol. Cell 14 (8), 3242-3253 (2003)
  MEDLINE   22806953
   PUBMED   12925760
  REMARK    GeneRIF: Overexpression of SWAP-70 altered the actin organization
            and lamellipodial morphology
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Rapalus,L., Minegishi,Y., Lavoie,A., Cunningham-Rundles,C. and
            Conley,M.E.
  TITLE     Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM
            syndrome and common variable immunodeficiency
  JOURNAL   Clin. Immunol. 101 (3), 270-275 (2001)
  MEDLINE   21583285
   PUBMED   11726218
  REMARK    GeneRIF: protein that functions as the only B cell-specific
            component of an isotype switch recombination
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Masat,L., Caldwell,J., Armstrong,R., Khoshnevisan,H.,
            Jessberger,R., Herndier,B., Wabl,M. and Ferrick,D.
  TITLE     Association of SWAP-70 with the B cell antigen receptor complex
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (5), 2180-2184 (2000)
  MEDLINE   20160925
   PUBMED   10681448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF134894.1 and
            BC000134.2.
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15"
     gene            1..3719
                     /gene="SWAP70"
                     /note="synonyms: HSPC321, SWAP-70, KIAA0640"
                     /db_xref="GeneID:23075"
                     /db_xref="MIM:604762"
     CDS             75..1832
                     /gene="SWAP70"
                     /note="go_function: calcium ion binding [goid 0005509]
                     [evidence IEA]"
                     /codon_start=1
                     /product="SWAP-70 protein"
                     /protein_id="NP_055870.1"
                     /db_xref="GI:30911101"
                     /db_xref="GeneID:23075"
                     /db_xref="MIM:604762"
                     /translation="MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLK
                     VPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKN
                     LTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFE
                     HYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMM
                     KKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFL
                     VKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ
                     EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELE
                     REKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQ
                     ARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEELEL
                     ERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAF
                     TEAELEEREKNWKEKKTTE"
ORIGIN      
        1 gaggttgagg ggcgtccgag gcgcggaggg gctggctggg caggaggggt tggcggggca
       61 gcagggccgc ggccatgggg agcttgaagg aggagctgct caaagccatc tggcacgcct
      121 tcaccgcact cgaccaggac cacagcggca aggtctccaa gtcccagctc aaggtccttt
      181 cccataacct gtgcacggtg ctgaaggttc ctcatgaccc agttgccctt gaagagcact
      241 tcagggatga tgatgagggt ccagtgtcca accagggcta catgccttat ttaaacaggt
      301 tcattttgga aaaggtccaa gacaactttg acaagattga attcaatagg atgtgttgga
      361 ccctctgtgt caaaaaaaac ctcacaaaga atcccctgct cattacagaa gaagatgcat
      421 ttaaaatatg ggttattttc aactttttat ctgaggacaa gtatccatta attattgtgt
      481 cagaagagat tgaatacctg cttaagaagc ttacagaagc tatgggagga ggttggcagc
      541 aagaacaatt tgaacattat aaaatcaact ttgatgacag taaaaatggc ctttctgcat
      601 gggaacttat tgagcttatt ggaaatggac agtttagcaa aggcatggac cggcagactg
      661 tgtctatggc aattaatgaa gtctttaatg aacttatatt agatgtgtta aagcagggtt
      721 acatgatgaa aaagggccac agacggaaaa actggactga acgatggttt gtactaaaac
      781 ccaacataat ttcttactat gtgagtgagg atctgaagga taagaaagga gacattctct
      841 tggatgaaaa ttgctgtgta gagtccttgc ctgacaaaga tggaaagaaa tgcctttttc
      901 tcgtaaaatg ttttgataag acttttgaaa tcagtgcttc agataagaag aagaaacagg
      961 agtggattca agccattcat tctactattc atctgttgaa gctgggcagc cctccaccac
     1021 acaaagaagc ccgccagcgt cggaaagaac tccggaagaa gcagctggct gaacaagagg
     1081 aactggagcg acaaatgaag gaactccagg ccgccaacga aagcaagcag caggagctgg
     1141 aggccgtgcg gaagaaactg gaggaagcag catctcgtgc agcagaagag gaaaagaaac
     1201 gccttcagac tcaagtggaa cttcaggcca ggttcagcac agagctggaa agagagaagc
     1261 ttatcagaca gcagatggaa gaacaggttg ctcaaaagtc ctctgaactg gaacagtatt
     1321 tacagcgagt acgggagctg gaagacatgt acctaaagct gcaggaggct cttgaagatg
     1381 agagacaggc ccggcaagat gaagagacag tgcggaagct tcaggccagg ttgttggagg
     1441 aagagtcttc caagagggct gaactagaaa agtggcactt ggagcagcag caggccattc
     1501 agacaaccga ggcggagaag caggagttgg agaatcagcg tgtcctgaag gaacaggccc
     1561 tgcaggaggc catggagcag ctggaggagc ttgagttaga acggaagcaa gcacttgagc
     1621 agtacgagga agttaaaaag aagctggaga tggcaactaa taagaccaag agctggaagg
     1681 acaaagtggc ccatcatgaa ggattaattc gactgataga accaggttca aagaaccctc
     1741 acctgatcac taactgggga cctgcagctt tcactgaggc agaacttgaa gagagagaga
     1801 agaactggaa agagaaaaag accacggagt gactgagctt gctggcagtc acgtcagtta
     1861 tgtagatact gcatggcagg agagctttac gctaaagaca aaagaaacag ctttgggggc
     1921 cgggcgtggg tgtcwcgcct gtaatcccag cactttggga ggccgaggcg ggtggatcac
     1981 ctgaggtcag gagttcaaga ccagcctggc caacctggtg aaaccctgtc tctactaaaa
     2041 atacaaaaaa aattagctga gcgtggtggc gggcgcctgt aatcccagct acttgggagg
     2101 ctgaggcagg agaatcactt gaacgtggga ggcggaggtt gcagcgagct gagatcatgc
     2161 cgttgtactc cagcttgggc aacagagtga gactccatct caaaacaaaa caaaacaaaa
     2221 caaaacaaaa aaacccggct ttgctgcttt taactcttct tccttctgtg cctctctaag
     2281 tgggtcagta tcctaaggaa gccttcttat ttatcttcct gcaaacaagg gttacctgaa
     2341 aagaaaaaaa aagtcaacat tgtcaagctg tttgtttact ctttctttga aaacatcacc
     2401 ttctgaaatt tgtcttttag ctctctcaga ttcttcccca aatgaggcag ggtgcagaca
     2461 gcacagtcag ctctgcagag tttggagggg ctcactgcca ctgggtactc agaacctctg
     2521 tggactggat gtcagctctt tcctttggca gcgtgtttcc ttttccgagt atgtgctgtt
     2581 aaactagatt ggccggttcg ctttccattt cctgacactt gacatggaat gcctttgacc
     2641 attggtgctc tgacagagaa gtcatggagt cattgccatt tcctggttgc ccttttggaa
     2701 tgtgatcctg ttagtagagg ttttctagct tctactaaga tatttctttc cctaaccatc
     2761 atacacttgg catgtttcat tcccatctcc tttcccctca ccttaaagga gactacccct
     2821 ttgccccata ttgtcaacct aattttctct cgtactctct ctagtgaatg atgtgctacc
     2881 aagtatatgc caggctgtga gaggattata ctgagtagta gaaagaagct aatttgaaat
     2941 aaaaattatt tgtataatta agaaagcaga ttagatgcac atggtcaaca ggaagttatc
     3001 catatgtctg ctagttagat tcaaaacatc ataaagatga tagcatgtca atatattagc
     3061 ctagccatta tgttagcctt tgttaggtgg gcagcttttc tgctttttcc cttcctctgt
     3121 ggtgacaacg gaggaaatat ccaacagaaa tacatctaac agggaaattg ggatcatagt
     3181 ttatatgcat ctgatttgaa aggagtattg aggaaggttt tcatatatga tctatctttg
     3241 gattaaaaag aacatttatg aaatcaagcc ttctaacact agttataatt gagaagcaac
     3301 agtaactccg tggacagcaa tcaagcttaa aattgtaaat aaatatgggg ataattcagt
     3361 tgttgcaaaa aaagggcaga attcagtaga ataaagtcct tttctcttac aggtattaaa
     3421 tgaggacaga gaacctcagg tgttcttatg ctagtgcttg ctgagtgcat actaagaaag
     3481 caattccaaa tagatgtata catctagaga gagtggtatt agagattcag tgtatgtatt
     3541 tatttacatg agaggaaact ggaatataat cccataaatt atcacctttt atgactggaa
     3601 aatatttgcc aatgaagaaa tggtctgtag gtatttgtct taagattttt ggctgtttaa
     3661 taaaaatgta actttaacgg tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_015516               2725 bp    mRNA    linear   PRI 22-NOV-2004
DEFINITION  Homo sapiens likely ortholog of chicken tsukushi (TSK), mRNA.
ACCESSION   NM_015516
VERSION     NM_015516.3  GI:55928826
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Charpentier,A.H., Bednarek,A.K., Daniel,R.L., Hawkins,K.A.,
            Laflin,K.J., Gaddis,S., MacLeod,M.C. and Aldaz,C.M.
  TITLE     Effects of estrogen on global gene expression: identification of
            novel targets of estrogen action
  JOURNAL   Cancer Res. 60 (21), 5977-5983 (2000)
   PUBMED   11085516
REFERENCE   3
  AUTHORS   Hattori,M., Ishii,K., Toyoda,A., Taylor,T.D., Hong-Seog,P.,
            Fujiyama,A., Yada,T., Totoki,Y., Watanabe,H. and Sakaki,Y.
  TITLE     Homo sapiens genomic DNA
  JOURNAL   Published Only in Database (2001)
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AP003119.2, AK091475.1 and
            BC020975.1.
            On Nov 22, 2004 this sequence version replaced gi:46094075.
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..2725
                     /gene="TSK"
                     /note="synonym: E2IG4"
                     /db_xref="GeneID:25987"
                     /db_xref="MIM:608015"
     CDS             173..1234
                     /gene="TSK"
                     /codon_start=1
                     /product="tsukushi"
                     /protein_id="NP_056331.2"
                     /db_xref="GI:46094076"
                     /db_xref="GeneID:25987"
                     /db_xref="MIM:608015"
                     /translation="MPWPLLLLLAVSGAQTTRPCFPGCQCEVETFGLFDSFSLTRVDC
                     SGLGPHIMPVPIPLDTAHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPT
                     AFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQGRAL
                     HVDLSHNLIHRLVPHPTRAGLPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLA
                     VIGPGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDLSGNPKLNWAGAEVFS
                     GLSSLQELDLSGTNLVPLPEALLLHLPALQSVSVGQDVRCRRLVREGTYPRRPGSSPK
                     VALHCVDTRDSAARGPTIL"
ORIGIN      
        1 cgcggccggc ccgagccgcc acccggcgcc cggcaggggg gagcctggct gcgggcgggg
       61 accggggggc gggccgcgcc gcgcggagaa aagcgctggc cggagggccc gcggccgggc
      121 cgccggggtg agcgtgccga ggcggctgtg gcgcaggctt ccagccccca ccatgccgtg
      181 gcccctgctg ctgctgctgg ccgtgagtgg ggcccagaca acccggccat gcttccccgg
      241 gtgccaatgc gaggtggaga ccttcggcct tttcgacagc ttcagcctga ctcgggtgga
      301 ttgtagcggc ctgggccccc acatcatgcc ggtgcccatc cctctggaca cagcccactt
      361 ggacctgtcc tccaaccggc tggagatggt gaatgagtcg gtgttggcgg ggccgggcta
      421 cacgacgttg gctggcctgg atctcagcca caacctgctc accagcatct cacccactgc
      481 cttctcccgc cttcgctacc tggagtcgct tgacctcagc cacaatggcc tgacagccct
      541 gccagccgag agcttcacca gctcacccct gagcgacgtg aaccttagcc acaaccagct
      601 ccgggaggtc tcagtgtctg ccttcacgac gcacagtcag ggccgggcac tacacgtgga
      661 cctctcccac aacctcattc accgcctcgt gccccacccc acgagggccg gcctgcctgc
      721 gcccaccatt cagagcctga acctggcctg gaaccggctc catgccgtgc ccaacctccg
      781 agacttgccc ctgcgctacc tgagcctgga tgggaaccct ctagctgtca ttggtccggg
      841 tgccttcgcg gggctgggag gccttacaca cctgtctctg gccagcctgc agaggctccc
      901 tgagctggcg cccagtggct tccgtgagct accgggcctg caggtcctgg acctgtcggg
      961 caaccccaag cttaactggg caggagctga ggtgttttca ggcctgagct ccctgcagga
     1021 gctggacctt tcgggcacca acctggtgcc cctgcctgag gcgctgctcc tccacctccc
     1081 ggcactgcag agcgtcagcg tgggccagga tgtgcggtgc cggcgcctgg tgcgggaggg
     1141 cacctacccc cggaggcctg gctccagccc caaggtggcc ctgcactgcg tagacacccg
     1201 ggattctgct gccaggggcc ccaccatctt gtgacaaatg gtgtggccca gggccacata
     1261 acagactgct gtcctgggct gcctcaggtc ccgagtaact tatgttcaat gtgccaacac
     1321 cagtggggag cccgcaggcc tatgtggcag cgtcaccaca ggagttgtgg gcctaggaga
     1381 ggctttggac ctgggagcca cacctaggag caaagtctca cccctttgtc tacgttgctt
     1441 ccccaaacca tgagcagagg gacttcgatg ccaaaccaga ctcgggtccc ctcctgcttc
     1501 ccttccccac ttatccccca agtgccttcc ctcatgcctg ggccggcctg acccgcaatg
     1561 ggcagagggt gggtgggacc ccctgctgca gggcagagtt caggtccact gggctgagtg
     1621 tccccttggg cccatggccc agtcactcag gggcgagttt cttttctaac atagcccttt
     1681 ctttgccatg aggccatgag gcccgcttca tccttttcta tttccctaga accttaatgg
     1741 tagaaggaat tgcaaagaat caagtccacc cttctcatgt gacagatggg gaaactgagg
     1801 ccttgagaag gaaaaaggct aatctaagtt cctgcgggca gtggcatgac tggagcacag
     1861 cctcctgcct cccagcccgg acccaatgca ctttcttgtc tcctctaata agccccaccc
     1921 tccccgcctg ggctcccctt gctgcccttg cctgttcccc attagcacag gagtagcagc
     1981 agcaggacag gcaagagcct cacaagtggg actctgggcc tctgaccagc tgtgcggcat
     2041 gggctaagtc actctgccct tcggagcctc tggaagctta gggcacattg gttccagcct
     2101 agccagtttc tcaccctggg ttggggtccc ccagcatcca gactggaaac ctacccattt
     2161 tcccctgagc atcctctaga tgctgcccca aggagttgct gcagttctgg agcctcatct
     2221 ggctgggatc tccaaggggc ctcctggatt cagtccccac tggccctgag cacgacagcc
     2281 cttcttaccc tcccaggaat gccgtgaaag gagacaaggt ctgcccgacc catgtctatg
     2341 ctctaccccc agggtagcat ctcagcttcc gaaccctggg ctgtttcctt agtcttcatt
     2401 ttataaaagt tgttgccttt ttaacggagt gtcactttca accggcctcc cctacccctg
     2461 ctggccgggg atggagacat gtcatttgta aaagcagaaa aaggttgcat ttgttcactt
     2521 ttgtaatatt gtcctgggcc tgtgttgggg tgttggggga agctgggcat cagtggccac
     2581 atgggcatca ggggctggcc ccacagagac cccacagggc agtgagctct gtcttccccc
     2641 acctgcctag cccatcatct atctaaccgg tccttgattt aataaacact ataaaaagtt
     2701 ctttgcttta aaaaaaaaaa aaaaa
//

LOCUS       NM_015627               2862 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens LDL receptor adaptor protein (ARH), mRNA.
ACCESSION   NM_015627
VERSION     NM_015627.1  GI:22027529
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Michaely,P., Li,W.P., Anderson,R.G., Cohen,J.C. and Hobbs,H.H.
  TITLE     The modular adaptor protein ARH is required for low density
            lipoprotein (LDL) binding and internalization but not for LDL
            receptor clustering in coated pits
  JOURNAL   J. Biol. Chem. 279 (32), 34023-34031 (2004)
   PUBMED   15166224
  REMARK    GeneRIF: findings indicate that low density lipoprotein (LDL)
            receptor adaptor protein(ARH) is required not only for
            internalization of the LDL.LDL Receptor complex but also for
            efficient binding of LDL to the receptor
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Nagai,M., Meerloo,T., Takeda,T. and Farquhar,M.G.
  TITLE     The adaptor protein ARH escorts megalin to and through endosomes
  JOURNAL   Mol. Biol. Cell 14 (12), 4984-4996 (2003)
  MEDLINE   23001048
   PUBMED   14528014
  REMARK    GeneRIF: ARH facilitates endocytosis of megalin, escorts megalin
            along its endocytic route
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Harada-Shiba,M., Takagi,A., Miyamoto,Y., Tsushima,M., Ikeda,Y.,
            Yokoyama,S. and Yamamoto,A.
  TITLE     Clinical features and genetic analysis of autosomal recessive
            hypercholesterolemia
  JOURNAL   J. Clin. Endocrinol. Metab. 88 (6), 2541-2547 (2003)
  MEDLINE   22672219
   PUBMED   12788851
  REMARK    GeneRIF: Single nucleotide polymorphism discovered among normal
            subjects at position 604 (cytosine to thymine: ARH-604C to
            ARH-604T), which changes proline residue at 202 to serine. ARH
            caused by mutation of cytosine to adenine at this same position.
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Barbagallo,C.M., Emmanuele,G., Cefal, Fiore,B., Noto,D.,
            Mazzarino,M.C., Pace,A., Brogna,A., Rizzo,M., Corsini,A.,
            Notarbartolo,A., Travali,S. and Averna,M.R.
  TITLE     Autosomal recessive hypercholesterolemia in a Sicilian kindred
            harboring the 432insA mutation of the ARH gene
  JOURNAL   Atherosclerosis 166 (2), 395-400 (2003)
  MEDLINE   22422499
   PUBMED   12535754
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Mishra,S.K., Watkins,S.C. and Traub,L.M.
  TITLE     The autosomal recessive hypercholesterolemia (ARH) protein
            interfaces directly with the clathrin-coat machinery
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (25), 16099-16104 (2002)
  MEDLINE   22364067
   PUBMED   12451172
  REMARK    GeneRIF: The autosomal recessive hypercholesterolemia (ARH) protein
            interfaces directly with the clathrin-coat machinery. In ARH
            patients, defective sorting adaptor function in hepatocytes leads
            to faulty LDL receptor traffic and hypercholesterolemia.
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Wilund,K.R., Yi,M., Campagna,F., Arca,M., Zuliani,G., Fellin,R.,
            Ho,Y.K., Garcia,J.V., Hobbs,H.H. and Cohen,J.C.
  TITLE     Molecular mechanisms of autosomal recessive hypercholesterolemia
  JOURNAL   Hum. Mol. Genet. 11 (24), 3019-3030 (2002)
  MEDLINE   22304933
   PUBMED   12417523
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   He,G., Gupta,S., Yi,M., Michaely,P., Hobbs,H.H. and Cohen,J.C.
  TITLE     ARH is a modular adaptor protein that interacts with the LDL
            receptor, clathrin, and AP-2
  JOURNAL   J. Biol. Chem. 277 (46), 44044-44049 (2002)
  MEDLINE   22313560
   PUBMED   12221107
  REMARK    GeneRIF: ARH functions as an adaptor protein that couples LDLR to
            the endocytic machinery
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Al-Kateb,H., B, Hoffmann,K., Strauch,K., Busjahn,A., N, Jouma,M.,
            Bautz,E.K., Dresel,H.A. and Luft,F.C.
  TITLE     Mutation in the ARH gene and a chromosome 13q locus influence
            cholesterol levels in a new form of digenic-recessive familial
            hypercholesterolemia
  JOURNAL   Circ. Res. 90 (9), 951-958 (2002)
  MEDLINE   22011792
   PUBMED   12016260
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Arca,M., Zuliani,G., Wilund,K., Campagna,F., Fellin,R.,
            Bertolini,S., Calandra,S., Ricci,G., Glorioso,N., Maioli,M.,
            Pintus,P., Carru,C., Cossu,F., Cohen,J. and Hobbs,H.H.
  TITLE     Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and
            mutations in ARH: a clinical and molecular genetic analysis
  JOURNAL   Lancet 359 (9309), 841-847 (2002)
  MEDLINE   21896162
   PUBMED   11897284
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Garcia,C.K., Wilund,K., Arca,M., Zuliani,G., Fellin,R., Maioli,M.,
            Calandra,S., Bertolini,S., Cossu,F., Grishin,N., Barnes,R.,
            Cohen,J.C. and Hobbs,H.H.
  TITLE     Autosomal recessive hypercholesterolemia caused by mutations in a
            putative LDL receptor adaptor protein
  JOURNAL   Science 292 (5520), 1394-1398 (2001)
  MEDLINE   21258423
   PUBMED   11326085
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117654.1 and BC029770.1.
            
            Summary: The protein encoded by this gene is a cytosolic protein
            which contains a phosphotyrosine binding (PTD) domain. The PTD
            domain has been found to interact with the cytoplasmic tail of the
            LDL receptor. Mutations in this gene lead to LDL receptor
            malfunction and cause the disorder autosomal recessive
            hypercholesterolaemia.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36-p35"
     gene            1..2862
                     /gene="ARH"
                     /note="synonyms: ARH2, FHCB1, FHCB2, MGC34705,
                     DKFZp586D0624"
                     /db_xref="GeneID:26119"
                     /db_xref="MIM:605747"
     CDS             25..951
                     /gene="ARH"
                     /note="RP11-70P17.2; LDL receptor adaptor protein (ARH);
                     go_process: development [goid 0007275] [evidence IEA]"
                     /codon_start=1
                     /product="LDL receptor adaptor protein"
                     /protein_id="NP_056442.1"
                     /db_xref="GI:22027530"
                     /db_xref="GeneID:26119"
                     /db_xref="MIM:605747"
                     /translation="MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLE
                     GMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDN
                     LTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLT
                     VAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTPPLKSLVATGNLLDLEET
                     AKAPLSTVSANTTNMDEVPRPQALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGL
                     TAQDMHYAQCLSPVDWDKPDSSGTEQDDLFSF"
     polyA_signal    2821..2826
                     /gene="ARH"
     polyA_site      2847
                     /gene="ARH"
ORIGIN      
        1 cggcggcggc ggccggagcg ggccatggac gcgctcaagt cggcggggcg ggcgctgatc
       61 cggagcccca gcttggccaa gcagagctgg gggggcggtg gccggcaccg caagctgcct
      121 gagaactgga cagacacgcg ggagacgctg ctggagggga tgctgttcag cctcaagtac
      181 ctgggcatga cgctagtgga gcagcccaag ggtgaggagc tgtcggccgc cgccatcaag
      241 aggatcgtgg ctacagctaa ggccagtggg aagaagctgc agaaggtgac tctgaaggtg
      301 tcgccacggg gaattatcct gacagacaac ctcaccaacc agctcattga gaacgtgtcc
      361 atatacagga tctcctattg cacagcagac aagatgcacg acaaggtgtt tgcatacatc
      421 gcccagagcc agcacaacca gagcctcgag tgccacgcct tcctctgcac caagcggaag
      481 atggcacagg ctgttaccct caccgtagcc caggccttca aagtcgcctt tgagttttgg
      541 caggtgtcca aggaagagaa agagaagagg gacaaagcca gccaagaggg aggggacgtc
      601 ctgggggccc gccaagactg cacccccccc ttgaagagct tggtcgccac tgggaacctg
      661 ctggacttag aggagacggc taaggccccg ctgtccacgg tcagcgccaa caccaccaac
      721 atggacgagg tgccgcggcc acaagccttg agtggcagca gtgttgtctg ggagctggat
      781 gatggcctgg atgaagcgtt ttcgaggctt gcccagtctc ggacaaaccc tcaggtcctg
      841 gacactggcc tgacagccca ggacatgcat tacgcccagt gcctctcgcc tgtcgactgg
      901 gacaagcctg acagcagcgg cacagagcag gatgacctct tcagcttctg agggcccggg
      961 gccagccgga cacaagcggc cctgacacgt gatggaccaa agccacctgc tgcgggggag
     1021 ccagttctgg ggcccgcctg ccacctctcc cagccctcag cattgtcagc ctgaagatca
     1081 gagctgcagc cagtcaggca ggggagagat ttttctttta agccctgctc tttctctgag
     1141 aaccaaaaga tgccttgaat atttattcag tgacttctgg cttatgctca gaagccagtc
     1201 tgcgtcaggc acgtctcctg ctgcgtgaca tgtgcagtgc tgtaatcggc tcccgcttgc
     1261 tctcctggag caagctctgc cctggctgtg ggtatcagga ctgtgaccaa agcatttcta
     1321 gtcccttctc tctttctaag gacccaaatt tccctggggg catcctgctt cctgaaagct
     1381 gttggatttc agtgattttt ccccccaccc cccagcacag gagagcaccc acagccgcag
     1441 aaggggaatg tgtcctcctg ctctgcttcc tcagggccca gcaggcgggg gtttgagccc
     1501 tggaccccag gctcttagag actaaggggc agctcctgac caaagacgat acagcttggc
     1561 actttaaagc attaacagca ggtgtgaccc tgagggctcc tccatggtgc tgcattgagt
     1621 ccagctttcc ttctgccctt cctccaggag aaggggccca aggtccccgt ggatggtctc
     1681 cacctgtgct tggaaccagt gtaactggct gctccctgct cccagggact gacacgggga
     1741 tcatctctgt gaccgccctc cgtcgggccc ctgcctgcct tctcccctcc acgcaaggct
     1801 gtgctcttcc tctggtttct gtgtgtccgt ttgagtgtct gcgccccgcc tccccatact
     1861 tcctgggatg atgtgtgaaa cctgacacct agatttattt ggaaatattc tatgaccact
     1921 ttacagatga ggaaactgag gcctcaagcg tggaggggta gagtgaagag tagaacccag
     1981 gtctgatgcc aaagctgctt tcttctctgc ctcctcctca cgcaactcac acctcctttt
     2041 cttctagctt tgttgtcctc ccaggaacca aaaaacccca gctattttct gaccaaaatg
     2101 tgtttcataa caaaccatct ggtgcctttc cacacagaac tggcaggagc ctcgtgtcct
     2161 gctagctgtc tctcttgttg atttccgtga aaatgcaagt gtttgaagtc tgctcattcc
     2221 gagggtgaaa caaaatccaa ccctgtcaga atcatgctgt tctctttgct gacactgtga
     2281 ccctgggtcg ggacagacca gcagcaatct gtctttagaa tcgctttcct tcctcccctt
     2341 ttgcccccgt ggggctcccg gcatcctgaa agccagcaaa gcctccagca tcttttccat
     2401 cctgaggtgc ctcccagtgg cctggcttgt cggagcaagt ttcatcagcc ctagggaaaa
     2461 cacggccctc ctgggaacct ccttacctgg agtaaccgga caccttagac ggaggtgcct
     2521 gagggtgggg tgggatttgc agggtcatta tcagaacatg aggataactt ccttgcccct
     2581 gctctgtagc cacctccttg gcaccggcct ctatttgtca taaggcggcg tgggcgaggc
     2641 ctgacacagg ccagccttgg cacgaggggg gccaggggtt ctgagaagcg ctgccctgtg
     2701 agagccacgc tggccttcgt ctccatctct ggttgacggg ctgtccgtgt gcctcctgtg
     2761 tgtctgcaga caagtcttgc tgtgctttat ttgtgaaact ttaatgagga aaaaacaaat
     2821 aataaatgtt ctcgttttga aactcaaaaa aaaaaaaaaa aa
//

LOCUS       NM_016006               1536 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens abhydrolase domain containing 5 (ABHD5), mRNA.
ACCESSION   NM_016006
VERSION     NM_016006.3  GI:33469972
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Lefevre,C., Jobard,F., Caux,F., Bouadjar,B., Karaduman,A.,
            Heilig,R., Lakhdar,H., Wollenberg,A., Verret,J.L., Weissenbach,J.,
            Ozguc,M., Lathrop,M., Prud'homme,J.F. and Fischer,J.
  TITLE     Mutations in CGI-58, the gene encoding a new protein of the
            esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman
            syndrome
  JOURNAL   Am. J. Hum. Genet. 69 (5), 1002-1012 (2001)
   PUBMED   11590543
  REMARK    GeneRIF: mutational analysis in Chanarin-Dorfman syndrome
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021958.1 and BG721387.1.
            On Aug 7, 2003 this sequence version replaced gi:31542302.
            
            Summary: The protein encoded by this gene belongs to a large family
            of proteins defined by an alpha/beta hydrolase fold, and contains
            three sequence motifs that correspond to a catalytic triad found in
            the esterase/lipase/thioesterase subfamily. It differs from other
            members of this subfamily in that its putative catalytic triad
            contains an asparagine instead of the serine residue. Mutations in
            this gene have been associated with Chanarin-Dorfman syndrome, a
            triglyceride storage disease with impaired long-chain fatty acid
            oxidation.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21"
     gene            1..1536
                     /gene="ABHD5"
                     /note="synonyms: CDS, CGI58, IECN2, NCIE2, MGC8731"
                     /db_xref="GeneID:51099"
                     /db_xref="MIM:604780"
     CDS             111..1160
                     /gene="ABHD5"
                     /note="comparative gene identification 58;
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: aminopeptidase activity [goid 0004177]
                     [evidence IEA];
                     go_process: aromatic compound metabolism [goid 0006725]
                     [evidence IEA];
                     go_process: proteolysis and peptidolysis [goid 0006508]
                     [evidence IEA]"
                     /codon_start=1
                     /product="CGI58 protein"
                     /protein_id="NP_057090.2"
                     /db_xref="GI:31542303"
                     /db_xref="GeneID:51099"
                     /db_xref="MIM:604780"
                     /translation="MAAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLK
                     CVPCTYKKEPVRISNGNKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNR
                     PVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAA
                     AYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRALGAALTPFNPLAGLRIAG
                     PFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRP
                     MLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSYVKTIAILGAGHYVYADQP
                     EEFNQKVKEICDTVD"
     polyA_signal    1404..1409
                     /gene="ABHD5"
     polyA_site      1428
                     /gene="ABHD5"
                     /evidence=experimental
ORIGIN      
        1 cgcatgcgct ggcggcctgc gccgccttaa gtgccgcgcc agcccggggc ggcccagtcg
       61 gcctgtcagc cggcttcgag ataagtcccg gcgcttgcgc ggcggcggct atggcggcgg
      121 aggaggagga ggtggactct gccgacaccg gagagaggtc aggatggcta actggttggc
      181 tccccacatg gtgccctacg tctatatcac accttaaaga agctgaagag aagatgttaa
      241 aatgtgtgcc ttgcacatac aaaaaagaac ctgttcgtat atctaatgga aataaaatat
      301 ggacactgaa gttctctcat aatatttcaa ataagactcc acttgtcctt ctccatggtt
      361 ttggaggagg tcttgggctc tgggcactga attttggaga tctttgcacc aacagacctg
      421 tctatgcttt tgacctattg ggttttggac gaagtagtag acccaggttt gacagtgatg
      481 cagaagaagt ggagaatcag tttgtggaat ccattgaaga gtggagatgt gccctaggat
      541 tggacaaaat gatcttgctt gggcacaacc taggtggatt cttggctgct gcttactcgc
      601 tgaagtaccc atcaagggtt aatcatctca ttttagtgga gccttggggt ttccctgaac
      661 gaccagacct tgctgatcaa gacagaccaa ttccagtttg gatcagagcc ttgggagcag
      721 cattgactcc ctttaaccct ttagctggcc taaggattgc aggacccttt ggtttaagtc
      781 tagtgcagcg tttaaggcct gatttcaaac gaaagtattc ttcaatgttc gaagacgata
      841 ctgtgacaga atacatctac cactgtaatg tgcagactcc aagtggtgag acagctttca
      901 agaatatgac tattccttat ggatgggcaa aaaggccaat gctccagcga attggtaaaa
      961 tgcaccctga cattccagtt tcagtgatct ttggcgcccg atcctgcata gatggcaatt
     1021 ctggcaccag catccagtcc ttacgaccac attcatatgt gaagacaata gctattcttg
     1081 gggcaggaca ttatgtatat gcagatcaac cagaagaatt caaccagaaa gtaaaggaga
     1141 tctgcgacac tgtggactga acacactgaa gctctgatgg gaaaacctgg tgactgatat
     1201 agttgttcag caataattca tagtctgtga tgaagagtag tgaatacaac acacaaccag
     1261 gcagccttct tgactatact ttgcacatgt tttctttagg aattcactca cacatttaaa
     1321 ccagttagtg ccttctagaa gaatggcttt cctttctcct acacaaaatt gaaatataca
     1381 agtctctaaa tataatacct ttaaataaaa ggttatttgt ccctctgaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//

LOCUS       NM_016839               2596 bp    mRNA    linear   PRI 12-JAN-2005
DEFINITION  Homo sapiens RNA binding motif, single stranded interacting protein
            1 (RBMS1), transcript variant 2, mRNA.
ACCESSION   NM_016839 NM_016837
VERSION     NM_016839.2  GI:46249391
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Haigermoser,C., Fujimoto,M., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Cloning and characterization of the genomic DNA of the human MSSP
            genes
  JOURNAL   Nucleic Acids Res. 24 (19), 3846-3857 (1996)
  MEDLINE   97025377
   PUBMED   8871567
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Takai,T., Nishita,Y., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Molecular cloning of MSSP-2, a c-myc gene single-strand binding
            protein: characterization of binding specificity and DNA
            replication activity
  JOURNAL   Nucleic Acids Res. 22 (25), 5576-5581 (1994)
  MEDLINE   95140618
   PUBMED   7838710
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Kanaoka,Y. and Nojima,H.
  TITLE     SCR: novel human suppressors of cdc2/cdc13 mutants of
            Schizosaccharomyces pombe harbour motifs for RNA binding proteins
  JOURNAL   Nucleic Acids Res. 22 (13), 2687-2693 (1994)
  MEDLINE   94316516
   PUBMED   8041632
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Negishi,Y., Nishita,Y., Sa, Kakizaki,I., Galli,I., Kihara,F.,
            Tamai,K., Miyajima,N., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Identification and cDNA cloning of single-stranded DNA binding
            proteins that interact with the region upstream of the human c-myc
            gene
  JOURNAL   Oncogene 9 (4), 1133-1143 (1994)
  MEDLINE   94181265
   PUBMED   8134115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018951.2 and X77494.1.
            On or before Apr 6, 2004 this sequence version replaced gi:8400719,
            gi:8400723.
            
            Summary: This gene encodes a member of a small family of proteins
            which bind single stranded DNA/RNA. These proteins are
            characterized by the presence of two sets of ribonucleoprotein
            consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and
            RNP2, originally described in RNA binding proteins, and required
            for DNA binding. These proteins have been implicated in such
            diverse functions as DNA replication, gene transcription, cell
            cycle progression and apoptosis. Multiple transcript variants,
            resulting from alternative splicing and encoding different
            isoforms, have been described. Several of these were isolated by
            virtue of their binding to either strand of an upstream element of
            c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13
            mutants of yeast (scr2), or as a potential human repressor of HIV-1
            and ILR-2 alpha promoter transcription (YC1). A pseudogene for this
            locus is found on chromosome 12.
            
            Transcript Variant: This variant (2), also known as MSSP-2,
            contains two additional exons, as compared to variant 1. It uses a
            downstream start codon and encodes a shorter isoform (b) that lacks
            N-terminal 33 aa but has an additional 16 aa segment in the middle
            region, as compared to isoform a.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..2596
                     /gene="RBMS1"
                     /note="synonyms: YC1, MSSP, SCR2, MSSP-1, MSSP-2, MSSP-3,
                     MGC3331, MGC15146"
                     /db_xref="GeneID:5937"
                     /db_xref="MIM:602310"
     CDS             641..1810
                     /gene="RBMS1"
                     /note="isoform b is encoded by transcript variant 2; c-myc
                     gene single strand binding protein 2; suppressor of cdc 2
                     (cdc13) with RNA binding motif 2;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_component: nucleus [goid 0005634] [evidence NAS] [pmid
                     7838710];
                     go_function: RNA binding [goid 0003723] [evidence IEA];
                     go_function: RNA binding [goid 0003723] [evidence TAS]
                     [pmid 8041632];
                     go_function: double-stranded DNA binding [goid 0003690]
                     [evidence NAS] [pmid 7838710];
                     go_function: double-stranded DNA binding [goid 0003690]
                     [evidence TAS] [pmid 7838710];
                     go_function: single-stranded DNA binding [goid 0003697]
                     [evidence NAS] [pmid 7838710];
                     go_function: single-stranded DNA binding [goid 0003697]
                     [evidence TAS] [pmid 7838710];
                     go_process: RNA processing [goid 0006396] [evidence TAS]
                     [pmid 8041632];
                     go_process: DNA replication [goid 0006260] [evidence NAS]
                     [pmid 7838710];
                     go_process: DNA replication [goid 0006260] [evidence TAS]
                     [pmid 7838710];
                     go_process: regulation of translation [goid 0006445]
                     [evidence TAS] [pmid 8041632];
                     go_process: nuclear mRNA splicing, via spliceosome [goid
                     0000398] [evidence IEA]"
                     /codon_start=1
                     /product="RNA binding motif, single stranded interacting
                     protein 1 isoform b"
                     /protein_id="NP_058523.1"
                     /db_xref="GI:8400724"
                     /db_xref="GeneID:5937"
                     /db_xref="MIM:602310"
                     /translation="MAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQD
                     LVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQ
                     QEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEK
                     CEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVR
                     LAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVAKETRENK
                     YRGSAIKVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGS
                     TGTYMPATSAMQGAYLPQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK"
     polyA_signal    2549..2554
                     /gene="RBMS1"
     polyA_site      2581
                     /gene="RBMS1"
ORIGIN      
        1 caccaagcgc agccgccgct gccgcacttt ccacttgtat tgatcacctc tcagccccgc
       61 gcagccggct cgcccgagcg gaccgcggcc agcgcgccag cccttggcag ccccggagca
      121 gtcgggctcc gggaggaaac tccttgggag cgccctgtcc ggggtgccct ctgcgctctg
      181 cagtgtcttt ctttctgcct gggaggagga ggaggaggag gaagaggagg aggaggagga
      241 ggaggaggag gaagaggagg aggaggagga ggacgtctgg tcccggctgg gaggtggagc
      301 agcggcagca gcagcagccg ccgccgccgc cgccgctgcc gccgccgccg gaaagggaga
      361 ggcaggagag cccgagactt ggaaacccca aagtgtccgc gaccctgcac ggcaggctcc
      421 cttccagctt catgggcaaa gtgtggaaac agcagatgta ccctcagtac gccacctact
      481 attaccccca gtatctgcaa gccaagtttg gaaggcattc gggaatacca agtgaaaagg
      541 aagagtgaag aacagaaaaa tgttagtggg atggcaaaca ctgtgaacat tgctgtttct
      601 agtgggccag aaaaatcagt ctctggtccc agcccacccc atggcccctc ccagtcccag
      661 caccaccagc agtaataaca acagtagcag cagtagcaac tcaggatggg atcagctcag
      721 caaaacgaac ctctatatcc gaggactgcc tccccacacc accgaccagg acctggtgaa
      781 gctctgtcaa ccatatggga aaatagtctc cacaaaggca attttggata agacaacgaa
      841 caaatgcaaa ggttatggtt ttgtcgactt tgacagccct gcagcagctc aaaaagctgt
      901 gtctgccctg aaggccagtg gggttcaagc tcaaatggca aagcaacagg aacaagatcc
      961 taccaacctc tacatttcta atttgccact ctccatggat gagcaagaac tagaaaatat
     1021 gctcaaacca tttggacaag ttatttctac aaggatacta cgtgattcca gtggtacaag
     1081 tcgtggtgtt ggctttgcta ggatggaatc aacagaaaaa tgtgaagctg ttattggtca
     1141 ttttaatgga aaatttatta agacaccacc aggagtttct gcccccacag aacctttatt
     1201 gtgtaagttt gctgatggag gacagaaaaa gagacagaac ccaaacaaat acatccctaa
     1261 tggaagacca tggcatagag aaggagaggt gagacttgct ggaatgacac ttacttacga
     1321 cccaactaca gctgctatac agaacggatt ttatccttca ccatacagta ttgctacaaa
     1381 ccgaatgatc actcaaactt ctattacacc ctatattgca tctcctgtat ctgcctacca
     1441 ggtggcaaag gaaaccagag aaaacaagta tcggggctct gctatcaagg tgcaaagtcc
     1501 ttcgtggatg caacctcaac catatattct acagcaccct ggtgccgtgt taactccctc
     1561 aatggagcac accatgtcac tacagcccgc atcaatgatc agccctctgg cccagcagat
     1621 gagtcatctg tcactaggca gcaccggaac atacatgcct gcaacgtcag ctatgcaagg
     1681 agcctacttg ccacagtatg cacatatgca gacgacagcg gttcctgttg aggaggcaag
     1741 tggtcaacag caggtggctg tcgagacgtc taatgaccat tctccatata cctttcaacc
     1801 taataagtaa ctgtgagatg tacagaaagg tgttcttaca tgaagaaggg tgtgaaggct
     1861 gaacaatcat ggatttttct gatcaattgt gctttaggaa attattgaca gttttgcaca
     1921 ggttcttgaa aacgttattt ataatgaaat caactaaaac tatttttgct ataagttcta
     1981 taaggtgcat aaaaccctta aattcatcta gtagctgttc ccccgaacag gtttatttta
     2041 gtaaaaaaaa aaaaacaaaa aacaaaaaca aaagattttt atcaaatgtt atgatgcaaa
     2101 aaaagaaaaa gaaaaaaaaa aagaaaagaa aacttcaatt ttctgggtat gcacaaagac
     2161 catgaagact tatccaagtg catgaccgga tttttgtggt tttgttcatt ttgtgtttaa
     2221 tttgtgtttt ttttttccag ctgtatgaaa tgggctttct gaagtttaaa tagtccgact
     2281 tcacccatgg tgttctgtgc ttgcagtgcg agtgttgctg taattcagtg ttgccgtcag
     2341 tgtctctttt cttagctttc tgtctttctt tcaacgtagt gtgaagtgtc ttatcctttt
     2401 ctatgaattc caatttgcct taactctttt gatgctgtag ctgtttcagt aaaagttagt
     2461 tcaaactaat gatgtagaat gctttgacca aatgagctgg tctattatgc cttgtaaaac
     2521 agcagcatag ggcttttaaa aggtagtcaa taaaagttgc tgaaattttg gcttttttaa
     2581 aaaaaaaaaa aaaaaa
//

LOCUS       NM_017779               3338 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens DEP domain containing 1 (DEPDC1), mRNA.
ACCESSION   NM_017779
VERSION     NM_017779.3  GI:41282232
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC065304.1.
            On Jan 25, 2004 this sequence version replaced gi:38488715.
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.2"
     gene            1..3338
                     /gene="DEPDC1"
                     /note="synonyms: DEP.8, SDP35, FLJ20354"
                     /db_xref="GeneID:55635"
     CDS             26..1609
                     /gene="DEPDC1"
                     /note="cell cycle control protein SDP35; 5830484J08Rik;
                     go_process: intracellular signaling cascade [goid 0007242]
                     [evidence IEA]"
                     /codon_start=1
                     /product="DEP domain containing 1"
                     /protein_id="NP_060249.2"
                     /db_xref="GI:38488716"
                     /db_xref="GeneID:55635"
                     /translation="MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCF
                     TAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDNNQ
                     LFRFPATSPLKTLPRRYPELRKNNIENFSKDKDSIFKLRNLSRRTPKRHGLHLSQENG
                     EKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIP
                     QYIMYNMANTSKRGVVILQNKSDDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVF
                     RTIADYFLDLPEPLLTFEYYELFVNILGLLQPHLERVAIDALQLCCLLLPPPNRRKLQ
                     LLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEEVDLDELLAGRLVSFLM
                     DHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYSYCKQISAQEFDEQK
                     VSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEAALFGDK
                     PTIKQPMLILRKPKFRSLR"
ORIGIN      
        1 gacgccaccg ggcgctgaca gacctatgga gagtcagggt gtgcctcccg ggccttatcg
       61 ggccaccaag ctgtggaatg aagttaccac atcttttcga gcaggaatgc ctctaagaaa
      121 acacagacaa cactttaaaa aatatggcaa ttgtttcaca gcaggagaag cagtggattg
      181 gctttatgac ctattaagaa ataatagcaa ttttggtcct gaagttacaa ggcaacagac
      241 tatccaactg ttgaggaaat ttcttaagaa tcatgtaatt gaagatatca aagggaggtg
      301 gggatcagaa aatgttgatg ataacaacca gctcttcaga tttcctgcaa cttcgccact
      361 taaaactcta ccacgaaggt atccagaatt gagaaaaaac aacatagaga acttttccaa
      421 agataaagat agcattttta aattacgaaa cttatctcgt agaactccta aaaggcatgg
      481 attacattta tctcaggaaa atggcgagaa aataaagcat gaaataatca atgaagatca
      541 agaaaatgca attgataata gagaactaag ccaggaagat gttgaagaag tttggagata
      601 tgttattctg atctacctgc aaaccatttt aggtgtgcca tccctagaag aagtcataaa
      661 tccaaaacaa gtaattcccc aatatataat gtacaacatg gccaatacaa gtaaacgtgg
      721 agtagttata ctacaaaaca aatcagatga cctccctcac tgggtattat ctgccatgaa
      781 gtgcctagca aattggccaa gaagcaatga tatgaataat ccaacttatg ttggatttga
      841 acgagatgta ttcagaacaa tcgcagatta ttttctagat ctccctgaac ctctacttac
      901 ttttgaatat tacgaattat ttgtaaacat tttgggcttg ctgcaacctc atttagagag
      961 ggttgccatc gatgctctac agttatgttg tttgttactt cccccaccaa atcgtagaaa
     1021 gcttcaactt ttaatgcgta tgatttcccg aatgagtcaa aatgttgata tgcccaaact
     1081 tcatgatgca atgggtacga ggtcactgat gatacatacc ttttctcgat gtgtgttatg
     1141 ctgtgctgaa gaagtggatc ttgatgagct tcttgctgga agattagttt ctttcttaat
     1201 ggatcatcat caggaaattc ttcaagtacc ctcttactta cagactgcag tggaaaaaca
     1261 tcttgactac ttaaaaaagg gacatattga aaatcctgga gatggactat ttgctccttt
     1321 gccaacttac tcatactgta agcagattag tgctcaggag tttgatgagc aaaaagtttc
     1381 tacctctcaa gctgcaattg cagaactttt agaaaatatt attaaaaaca ggagtttacc
     1441 tctaaaggag aaaagaaaaa aactaaaaca gtttcagaag gaatatcctt tgatatatca
     1501 gaaaagattt ccaaccacgg agagtgaagc agcacttttt ggtgacaaac ctacaatcaa
     1561 gcaaccaatg ctgattttaa gaaaaccaaa gttccgtagt ctaagataac taactgaatt
     1621 aaaaattatg taatacttgt ggaactttga taaatgaagc catatctgag aatgtagcta
     1681 ctcaaaagga agtctgtcat taataaggta tttctaaata aacacattat gtaaggaagt
     1741 gccaaaatag ttatcaatgt gagactctta ggaaactaac tagatctcaa ttgagagcac
     1801 ataacaatag atgataccaa atactttttg tttttaacac agctatccag taaggctatc
     1861 atgatgtgtg ctaaaatttt atttacttga attttgaaaa ctgagctgtg ttagggatta
     1921 aactataatt ctgttcttaa aagaaaattt atctgcaaat gtgcaagttc tgagatatta
     1981 gctaatgaat tagttgtttg gggttacttc tttgtttcta agtataagaa tgtgaagaat
     2041 atttgaaaac tcaatgaaat aattctcagc tgccaaatgt tgcactcttt tatatattct
     2101 ttttccactt ttgatctatt tatatatatg tatgtgtttt taaaatatgt gtatatttta
     2161 tcagatttgg ttttgcctta aatattatcc ccaattgctt cagtcattca tttgttcagt
     2221 atatatattt tgaattctag ttttcataat ctattagaag atggggatat aaaagaagta
     2281 taaggcaatc atatattcat tcaaaagata tttatttagc aactgctatg tgcctttcgt
     2341 tgttccagat atgcagagac aatgataaat aaaacatata atctcttcca taaggtattt
     2401 attttttaat caagggagat acacctatca gatgtttaaa ataacaacac tacccactga
     2461 aatcagggca tatagaatca ttcagctaaa gagtgacttc tatgatgatg gaacaggtct
     2521 ctaagctagt ggttttcaaa ctggtacaca ttagactcac ccgaggaatt ttaaaacagc
     2581 ctatatgccc agggcctaac ttacactaat taaatctgaa ttttggggat gttgtatagg
     2641 gattagtatt ttttttaatc taggtgattc caatattcag ccaactgtga gaatcaatgg
     2701 cctaaatgct ttttataaac atttttataa gtgtcaagat aatggcacat tgactttatt
     2761 ttttcattgg aagaaaatgc ctgccaagta taaatgactc tcatcttaaa acaaggttct
     2821 tcaggtttct gcttgattga cttggtacaa acttgaagca agttgccttc taatttttac
     2881 tccaagattg tttcatatct attccttaag tgtaaagaaa tatataatgc atggtttgta
     2941 ataaaatctt aatgtttaat gactgttctc atttctcaat gtaatttcat actgtttctc
     3001 tataaaatga tagtattcca tttaacatta ctgattttta ttaaaaacct ggacagaaaa
     3061 ttataaatta taaatatgac tttatcctgg ctataaaatt attgaaccaa aatgaattct
     3121 ttctaaggca tttgaatact aaaacgttta ttgtttatag atatgtaaaa tgtggattat
     3181 gttgcaaatt gagattaaaa ttatttgggg ttttgtaaca atataatttt gcttttgtat
     3241 tatagacaaa tatataaata ataaaggcag gcaactttca tttgcaaaaa aaaaaaaaaa
     3301 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_017785               2561 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens hypothetical protein FLJ20364 (FLJ20364), mRNA.
ACCESSION   NM_017785
VERSION     NM_017785.2  GI:21361652
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC012568.1.
            On Jun 10, 2002 this sequence version replaced gi:8923338.
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..2561
                     /gene="FLJ20364"
                     /db_xref="GeneID:54908"
     CDS             146..1963
                     /gene="FLJ20364"
                     /codon_start=1
                     /product="hypothetical protein FLJ20364"
                     /protein_id="NP_060255.2"
                     /db_xref="GI:21361653"
                     /db_xref="GeneID:54908"
                     /translation="MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKC
                     RNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSH
                     GQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMS
                     SEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKE
                     AVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMK
                     VKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLL
                     GEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQ
                     RMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLK
                     KRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIH
                     TPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQT
                     EVKEGKETSSKLEKETCKKSHPILYVSSKSTPETQCPQQ"
ORIGIN      
        1 gggggactcg agagctagct gagcgaatgg gccggcgact gtggagttag cgtcctcaat
       61 gtggacgccc tgagctccca ttaggagccg ctggctgcgg cagcagggga ctagcgtgaa
      121 agttggctaa aaaaaagaaa agaacatgga ggcagatata atcacaaatc ttcgatgcag
      181 gctcaaagag gctgaagaag agcgactaaa agctgcacag tatggtttac aactagtaga
      241 gagtcaaaat gaattacaga atcaattgga taaatgtcgt aatgaaatga tgaccatgac
      301 tgagagttat gaacaagaaa aatataccct tcaaagagaa gttgaactca agagtcgaat
      361 gttagaaagt ttgagctgcg aatgtgaagc tattaaacaa caacaaaaaa tgcacctgga
      421 gaaattggaa gaacaactaa gcagaagcca tggacaggaa gtgaatgaac taaaaactaa
      481 gatagaaaaa ctgaaagtgg aattagatga agccaggctt agtgaaaagc agctgaagca
      541 ccaagtagat catcagaagg aactcctctc ttgtaaatca gaggaactgc gcgtaatgtc
      601 tgaacgtgtg caggaaagca tgtcttcaga gatgctggct cttcaaattg agctgacaga
      661 aatggagagt atgaagacca ccctcaaaga agaagtgaat gaactacaat acagacaaga
      721 acagctagaa cttcttatta ctaacctaat gcgccaggta gaccggctta aagaggaaaa
      781 agaggagcga gagaaagaag cagtttctta ctataatgcc ctagagaaag ctcgtgtagc
      841 aaatcaagat cttcaggtac agttggacca ggcactccag caagccttgg atcccaatag
      901 taaaggcaac tctttgtttg cagaggtgga agatcgaagg gcagcaatgg aacgtcagct
      961 tatcagtatg aaagtcaagt atcagtcact aaagaagcaa aatgtattta acagagaaca
     1021 gatgcagaga atgaagttac aaattgccac gttgctacag atgaaagggt ctcaaactga
     1081 atttgagcag caggaacggt tgcttgccat gttggagcag aagaatggtg aaataaaaca
     1141 tcttttaggt gaaattagaa atctggagaa atttaagaat ttatatgaca gtatggaatc
     1201 taagccttca gtcgactctg gtactctgga agataacacc tattatacag atttacttca
     1261 gatgaagctg gataacttaa acaaagaaat tgaaagcact aaaggtgaat tgtccataca
     1321 gcgaatgaaa gcattatttg agagccagcg ggctctagat attgagcgaa aactttttgc
     1381 aaatgaaaga tgcctccagc tttcagaaag tgaaaatatg aaactgagag ctaaactaga
     1441 tgaattgaaa ctaaaatatg aacctgaaga gacagttgaa gtgcctgtac tgaaaaagag
     1501 gcgtgaggtg ctccctgtgg atataaccac cgctaaagat gcatgtgtca acaacagtgc
     1561 tctcggggga gaagtttatc gattaccgcc tcagaaagag gagacacagt cctgccctaa
     1621 cagtttagaa gataacaact tgcaattaga aaaatcagtt tctatacaca caccagtagt
     1681 cagtctctct cctcacaaaa atctgcccgt ggatatgcag ctgaagaagg aaaagaaatg
     1741 tgtgaaactc ataggagttc ccgctgacgc tgaggcctta agtgaaagaa gtggaaacac
     1801 ccctaactct cccaggttag ctgctgaatc aaagcttcaa acagaagtta aagaaggaaa
     1861 agaaacttca agcaaattgg aaaaagaaac ttgtaagaaa tcacacccta ttctatatgt
     1921 gtcttctaaa tctactccag agacccagtg ccctcaacag taaagacttt tctttaataa
     1981 gagtacggtg ccacttgcct caaaagttac tatggtgctt aagattgtct tgatctgaca
     2041 tatatcacct tctgggttat ttactcattg tgccaggacc tggcattttc atgtgccttt
     2101 gaccaagtgt tcagaatttg cttgactcta acctggagag cttcttaagt gatgcccctt
     2161 catggagctt ctatgacagt gaataaacta ttaattgaag gaaaatgtta taattaatgt
     2221 atctatttgc tgcattgtat atggattaaa tgataaaaaa caagtaatct accctcagag
     2281 ccatgtattt gagaatgctt caatcatatt ttcctatgta ctttttttta taaacttagt
     2341 tttagactat gttgtaaaaa tgggaaggtt gtaaactatg ttgtaaaaat aggaaatgtg
     2401 gcttaaaata tatacattat attgtttcag gattttgtca gtgtttaaag aaccaatgtt
     2461 catctttgta tttatataca tgatttaaat tttgtctaaa attttaaata aaactgcagt
     2521 gatttatccg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//

LOCUS       NM_017851               2551 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens poly (ADP-ribose) polymerase family, member 16
            (PARP16), mRNA.
ACCESSION   NM_017851
VERSION     NM_017851.4  GI:52851456
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC006389.1.
            On Sep 30, 2004 this sequence version replaced gi:46195793.
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2551
                     /gene="PARP16"
                     /note="synonyms: C15orf30, FLJ20509, FLJ25281"
                     /db_xref="GeneID:54956"
     CDS             255..1226
                     /gene="PARP16"
                     /note="chromosome 15 open reading frame 30"
                     /codon_start=1
                     /product="poly (ADP-ribose) polymerase family, member 16"
                     /protein_id="NP_060321.3"
                     /db_xref="GI:46195794"
                     /db_xref="GeneID:54956"
                     /translation="MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGK
                     AEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVI
                     DHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPP
                     KSRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR"
ORIGIN      
        1 caacctcccc gccgacccgc ggtccaggcc tcggtctctc tcttcggcgg cgagccgcgg
       61 cccagacccc ggcagaggac acttgtcggc acgttctcac ccctgtcatc tcagccccct
      121 gcctagctcc accccaggct tgggaacccg gcccctgacg gcccattgtc cgcgggccca
      181 gcccccgcgc tgaacgcacg ctcgcccttg cccctaacca gcgcgtctac cccggcaacg
      241 cgcagtgacc tgggatgcag ccctcaggct gggcggccgc cagggaggcg gcgggccgcg
      301 acatgctggc cgccgacctc cggtgcagcc tcttcgcctc ggccctgcag agctacaagc
      361 gcgactcggt gctgcggccc ttccccgcgt cctacgcccg cggcgactgt aaggactttg
      421 aagccctgct tgcagatgcc agcaagttac ctaacctgaa agaacttctc cagtcctccg
      481 gagacaacca caaacgggcc tgggacctgg tgagctggat tttatcctca aaggtcctga
      541 caatccacag tgcagggaag gcagagtttg aaaagatcca aaagctgact ggggctcctc
      601 acacgcctgt tcctgcaccg gacttcctgt ttgaaattga gtactttgac ccagccaacg
      661 ccaaatttta tgagaccaaa ggagaacgag acctaatcta tgcatttcat ggtagccgcc
      721 tagaaaactt ccattccatt atccacaatg gcctgcactg ccatctgaac aagacatcct
      781 tgttcggaga ggggacctac ctcaccagtg acttgagcct ggccctcata tacagccccc
      841 atggccatgg gtggcagcac agcctcctcg gccccatcct tagctgtgtg gccgtgtgtg
      901 aggtcattga ccatccggac gtcaagtgcc aaaccaagaa gaaggattcc aaggagatag
      961 atcgcagacg agcgagaatc aaacatagtg aagggggaga catccctccc aagtacttcg
     1021 tggtcaccaa taaccagctg ctgcgagtga agtacctcct ggtgtattca cagaagccac
     1081 ccaagagcag ggcttcgagc cagctctcct ggttttccag ccattggttt accgtcatga
     1141 tatccctgta tctgctgctg ctgctcatag tgagtgtcat caactcctct gctttccaac
     1201 acttttggaa tcgtgcgaaa agataatctt tctgggcctg gtgtgggggc tacctcaact
     1261 atgtgcctta tggtaacttg ttctgtacct cctatgcctc atgtccagcc aggttgagcc
     1321 taggggccag ttgggggacc acaggacaat tttcatatgg cctaaatgta tccattgcct
     1381 ttgatgatgt tcccagccat actccagtca acggggacta ctagtccctc actcttaggt
     1441 tttaggggag tccttccatc tgctccttct taaactgtcc tagggagttg gcttttcagc
     1501 cagggccaaa ggaaaaagcc ctgctgcatt taaaaacaaa gtgtccaagc tgtcagtggt
     1561 gtgtttacaa tctctcctgg cagaggttgg ccctttctct aatgccttct ggaaggcgga
     1621 aaatgtggga actataaatc actaggcggt tgccttgttt tgacttgaga cacccaagag
     1681 gaacagtcat gtttctcata aaaatcagtg ggatcatttt tgaattccat cagcctttgt
     1741 atgtgagtgc aaaacatttt aacagttttc tcaaatcaac aaacagcctt ctcctatagc
     1801 tgtacttgcc cccctcccca aaaaaccatg gatgagaaag aaaggagtca ggggcctgat
     1861 aaaaaataca gacttaatga gcaactcaag atgagaaaac tgctcttttt ccaaaaatta
     1921 ccaactgctg attacagctg aaatggaacc aaatgtttgt tttctgattt ttttttaata
     1981 gctgtttaac aaattagtct ttgctgagta aaaggggaaa tttctaaacc tagtgcactg
     2041 tttggccagt gtccacagcc tcttttctgg ctgtgtttta gagaaaggga tttgagctat
     2101 aggctcgcct cctgttctca ttctcacaaa gctgccttga ctgtggcctg caaccacgag
     2161 tgccatgctt tcaggtcttc tgtggcctac tggccttcaa gacagaggcc tgccccagtg
     2221 tgccacagat ccatgtggat ggagcctcct tcagaggggt cacaggtctt tgagactcag
     2281 cctgggcttt aatgtgtagg aaaagccttc tggccaccca gagagccgga gccctgcttg
     2341 ctgtattctc tgctcccttc ttcctgctgg gttttagcca taatagggcc cggtacgatt
     2401 tgggagtgac atttctgtaa agaagaggaa aaatcatttt tctataattt gtaaagttgt
     2461 gaaagagcca ctaccacagt ttttacattg attattggaa catttcagaa taaataaaga
     2521 tattttctta atgaaaaaaa aaaaaaaaaa a
//

LOCUS       NM_017966               2711 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens vacuolar protein sorting 37C (yeast) (VPS37C), mRNA.
ACCESSION   NM_017966 XM_373413
VERSION     NM_017966.4  GI:57863313
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Eastman,S.W., Martin-Serrano,J., Chung,W., Zang,T. and
            Bieniasz,P.D.
  TITLE     Identification of Human VPS37C, a Component of Endosomal Sorting
            Complex Required for Transport-I Important for Viral Budding
  JOURNAL   J. Biol. Chem. 280 (1), 628-636 (2005)
   PUBMED   15509564
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AL834261.1 and BM450171.1.
            On or before Jan 26, 2005 this sequence version replaced
            gi:42659665, gi:38490555.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2711
                     /gene="VPS37C"
                     /note="synonym: FLJ20847"
                     /db_xref="GeneID:55048"
     CDS             61..1128
                     /gene="VPS37C"
                     /codon_start=1
                     /product="vacuolar protein sorting 37C"
                     /protein_id="NP_060436.4"
                     /db_xref="GI:57863314"
                     /db_xref="GeneID:55048"
                     /translation="METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALA
                     TNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLD
                     LLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKP
                     RASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPT
                     AHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTP
                     MGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPY
                     PPGPAPPYGFPPPPGPAWPGY"
     polyA_signal    2671..2676
                     /gene="VPS37C"
     polyA_site      2692
                     /gene="VPS37C"
ORIGIN      
        1 tgggcgcggc tgcggtttaa cccgcggtgg cggcggcgac ggcggccctg gcagggaagg
       61 atggagacgc tgaaggataa gaccctgcag gagctggagg agttgcagaa tgactcggag
      121 gcgattgacc agctggccct ggagtcccct gaggtccagg acctacagct ggaacgggag
      181 atggcactgg ccaccaaccg gagcctggca gagcggaact tggagttcca gggtcccctg
      241 gagatcagcc gctcaaacct ctcggataga taccaggagc tccggaagct cgtggagcgg
      301 tgccaggagc agaaggcaaa gctggagaaa ttttcttcag cactgcagcc agggaccttg
      361 ttagaccttc tgcaggtgga aggcatgaag atcgaagaag agtccgaggc catggctgag
      421 aagttcctgg agggcgaggt gcccctggaa acgttcctgg agaatttttc ctccatgagg
      481 atgctgtccc acctgcgccg ggttcgcgtg gaaaagctcc aggaagtggt gaggaagccc
      541 agggcttccc aggagctggc cggcgatgcc cctccacccc gtccaccacc cccggtgcgc
      601 ccagtccccc agggaacacc ccctgtggtt gaagagcagc cgcagccacc attagccatg
      661 cctccctacc ctttgcccta cagcccatcc cccagcctgc ctgtgggccc cactgcccat
      721 ggagccctgc caccggcccc tttcccagta gtgtcccagc cctccttcta cagcgggcct
      781 ctgggcccca cttacccggc agcccagctt ggacccaggg gtgctgcggg ttactcctgg
      841 tccccacaga ggagcatgcc accccggccg ggctatcctg ggaccccaat gggtgcctct
      901 gggcctgggt accccttgcg gggaggcagg gcccccagtc ctggttatcc tcaacagtcc
      961 ccataccccg caacaggagg aaaacctccc tacccaatac agcctcagct ccccagcttt
     1021 ccaggccagc cccagccctc agtgcccctg cagccccctt atccccccgg gcccgcccct
     1081 ccctatgggt tcccaccacc gccggggcct gcctggcctg ggtattagac acactcctgg
     1141 ccctcggccc ctccctagtc ccacccacgc tcaacctttg gcccagccat cgccgagatt
     1201 cgagggtcaa ctggaagtgg cgttggtgct ccctgtggac ttgcgtcggc acccagaggc
     1261 cttggaggga caaggcactg ggcggtgtga ctggtcatgg cacttgctgg ccttctggcc
     1321 agaggtcctc ctggaagccc ctcctttcag tgcctggctg cagcggtgct agccaggctg
     1381 gagtccagca cctctcgccg gtgtctgtgt gagtgagcgc atgtgcgcat ttatgagcat
     1441 ctacttgcgg ctgcactcag ggccatttga acccagtgca gagttatctc tatgaggagg
     1501 ccccgggtct ccagccccct ccatctcccc tggggtttgg catatttgac atggagcccc
     1561 atgccaaggg atgcagctgt tggtgtctgt ccagtccatt caaggctagc ctgcccatgc
     1621 actgtggcag gggttggatt ggagggagag aacagagttg ggaaaaacaa caggtttgag
     1681 tcctataaag ccataattta actccagtag ctgatgtcag acaagcttgt cctatgtcct
     1741 atttgagtgg cagcagcgcc agcccagcaa gaaggctggg ggttgtcaag gttgtcccca
     1801 gaccttgctt gcagtggttg gagaacccag ggggctgcct tgggccctct ggccagaggg
     1861 aagcgggcag ctctagccct ggagattgtg gtcacattgg ggcttgttta ggattggagg
     1921 gccaggtcac ctccccagcc accctccctt ctctcctctg gggtccccac tttagggcga
     1981 ctttgcccga ggcccacgca tccatccact cctttagtgc cttgaatctc attcacaagc
     2041 agccccctcc cttcccctcc ccttctcact ctgttgatgt aatcctccca cccccagtgt
     2101 ccatcctaag acaggcatca aaagaggccc taactttact tcccaaatgg tgctttttaa
     2161 aaaacaccat cactacatta ggggcaattt tttcacacct ccctgtcttc agaatgtaaa
     2221 gggtggggat tatgtctctg tttaatatgc agccccctgc actgtggggt ttggggcatg
     2281 ttcagtaata agaatgaata caatagacaa agggggtgtg atgagtgtta acttggttgt
     2341 tccagaggta aaccaggtct cagggaagag cctggagctg ctattgctta ggaagttgta
     2401 cgtgccttga aatgtccact acctgaggac gcagcatctg gtgggcccgg ggctgctggg
     2461 gccaaggagg gaccttgacc ttctggtgcc tgcccctccc cggcctatgt gccatccgcg
     2521 tgacgctagg tcagcgctgc cggttcttta ccaaatgtgc ttgcttctcc taagttattt
     2581 ataaagagaa atcactaatg gactctactg gtttgagtgc ttctgagctg gatgaccgac
     2641 cgcctgtatg tttgtgtaat taattgccat aataaacttt gatgagtcac ataaaaaaaa
     2701 aaaaaaaaaa a
//

LOCUS       NM_017994               1929 bp    mRNA    linear   PRI 15-OCT-2004
DEFINITION  Homo sapiens hypothetical protein FLJ10099 (FLJ10099), mRNA.
ACCESSION   NM_017994
VERSION     NM_017994.3  GI:34222332
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC041764.2.
            On Aug 26, 2003 this sequence version replaced gi:31542639.
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..1929
                     /gene="FLJ10099"
                     /db_xref="GeneID:55069"
     CDS             234..1178
                     /gene="FLJ10099"
                     /codon_start=1
                     /product="hypothetical protein FLJ10099"
                     /protein_id="NP_060464.1"
                     /db_xref="GI:8922229"
                     /db_xref="GeneID:55069"
                     /translation="MFSINPLENLKVYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARASTQSPQ
                     ALEDSGPVNISVSITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPTAWSSDDCALHGHCEQVVFTACMTLTASPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALAEA"
ORIGIN      
        1 agcccgaact gaggcggcgg cgggagcccg gttggcgtct ggtcttcgcg tcggccccgc
       61 ggagccagac gctgcccccg gcgcggggag aagatggtgc cgagcggcct cgggcccgcc
      121 acgcgccgcc acgagtgagc ccagcgcgac cgcgggcgtc cgccgagcag ctggcccggc
      181 tgggcccggg gcgcgcagct gcccgccggg gcggggtgga gctgatcaga ataatgttca
      241 gcatcaaccc cctggagaac ctgaaggtgt acatcagcag tcggcctccc ctggtggtct
      301 tcatgatcag cgtaagcgcc atggccatag ctttcctgac cctgggctac ttcttcaaaa
      361 tcaaggagat taaatcccca gaaatggcag aggattggaa tacttttctg ctacggttca
      421 atgatttgga cttgtgtgta tcagagaatg aaaccctcaa gcatctcaca aacgacacca
      481 caactccgga aagtacaatg accagcgggc aggcccgagc ttccacccag tccccccagg
      541 ccctggagga ctcgggcccg gtgaatatct cagtctcaat caccctaacc ctggacccac
      601 tgaaaccctt cggagggtat tcccgcaacg tcacccatct gtactcaacc atcttagggc
      661 atcagattgg actttcaggc agggaagccc acgaggagat aaacatcacc ttcaccctgc
      721 ctacagcgtg gagctcagat gactgcgccc tccacggtca ctgtgagcag gtggtattca
      781 cagcctgcat gaccctcacg gccagccctg gggtgttccc cgtcactgta cagccaccgc
      841 actgtgttcc tgacacgtac agcaacgcca cgctctggta caagatcttc acaactgcca
      901 gagatgccaa cacaaaatac gcccaagatt acaatccttt ctggtgttat aagggggcca
      961 ttggaaaagt ctatcatgct ttaaatccca agcttacagt gattgttcca gatgatgacc
     1021 gttcattaat aaatttgcat ctcatgcaca ccagttactt cctctttgtg atggtgataa
     1081 caatgttttg ctatgctgtt atcaagggca gacctagcaa attgcgtcag agcaatcctg
     1141 aattttgtcc cgagaaggtg gctttggctg aagcctaatt ccacagctcc ttgttttttg
     1201 agagagactg agagaaccat aatccttgcc tgctgaaccc agcctgggcc tggatgctct
     1261 gtgaatacat tatcttgcga tgttgggtta ttccagccaa agacatttca agtgcctgta
     1321 actgatttgt acatatttat aaaaatctat tcagaaattg gtccaataat gcacgtgctt
     1381 tgccctgggt acagccagag cccttcaacc ccaccttgga cttgaggacc tacctgatgg
     1441 gacgtttcca cgtgtctcta gagaaggatt cctggatcta gctggtcacg acgatgtttt
     1501 caccaaggtc acaggagcat tgcgtcgctg atggggttga agtttggttt ggttcttgtt
     1561 tcagcccaat atgtagagaa catttgaaac agtctgcacc tttgatacgg tattgcattt
     1621 ccaaagccac caatccattt tgtggatttt atgtgtctgt ggcttaataa tcatagtaac
     1681 aacaataata cctttttctc cattttgctt gcaggaaaca taccttaagt tttttttgtt
     1741 ttgtttttgt ttttttgttt tttgttttcc tttatgaaga aaaaataaaa tagtcacatt
     1801 ttaatactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaacc cacgcgtccg cccacgcgtc
     1861 cgcggacgcg tgggcggacg cacgcgtccg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaa
//

LOCUS       NM_018090               2037 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens hypothetical protein FLJ10420 (FLJ10420), mRNA.
ACCESSION   NM_018090
VERSION     NM_018090.3  GI:39725692
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC018914.2.
            On Dec 11, 2003 this sequence version replaced gi:20127581.
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2037
                     /gene="FLJ10420"
                     /db_xref="GeneID:55707"
     CDS             25..816
                     /gene="FLJ10420"
                     /note="RP4-798A10.1"
                     /codon_start=1
                     /product="hypothetical protein FLJ10420"
                     /protein_id="NP_060560.1"
                     /db_xref="GI:8922416"
                     /db_xref="GeneID:55707"
                     /translation="MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSG
                     RLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRR
                     AFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKL
                     NIANMKKKEGAAGNPRVRPASTGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAV
                     APSSGGAPVPWPQPNPATADIWGDFTKSTGSTSSQTQPGTGWVQF"
ORIGIN      
        1 gttcggtggg ctccaggcgt cgcgatggag gagagcgggt acgagtcggt gctctgtgtc
       61 aagcctgacg tccacgtcta ccgcatccct ccgcgggcta ccaaccgtgg ctacagggct
      121 gcggagtggc agctggacca gccatcatgg agtggccggc tgaggatcac tgcaaaggga
      181 cagatggcct acatcaagct ggaggacagg acgtcagggg agctctttgc tcaggccccg
      241 gtggatcagt ttcctggcac agctgtggag agtgtgacgg attccagcag gtacttcgtg
      301 atccgcatcg aagatggaaa tgggcgacgg gcgtttattg gaattggctt cggggaccga
      361 ggtgatgcct ttgacttcaa tgttgcattg caggaccatt tcaagtgggt gaaacagcag
      421 tgtgaatttg caaaacaagc ccagaaccca gaccaaggcc ctaaactgga cctgggcttc
      481 aaggagggcc agaccatcaa gctcaacatc gcaaacatga agaagaagga aggagcagct
      541 gggaatcccc gagtccggcc tgccagcaca ggagggctga gcctgcttcc ccctccccca
      601 ggggggaaaa cctccaccct gatccctccc cctggggagc agttggctgt ggggggatcc
      661 ctcgtccagc cagcagttgc tcccagttca ggaggtgctc ctgtaccctg gccacagccc
      721 aatcctgcca ctgctgacat ctggggagac tttaccaaat ctacaggatc aacttccagc
      781 cagacccagc caggcacagg ctgggtccag ttctgacctg agcacggttt ttcctcatgt
      841 gacttctggg aaggcgctcc ctcatctggg ccaaaggaag gaggacgaag ccctcctcag
      901 ctggcctgtg tttggggcat gaatctctcc tctcctcctt gtctggctct gttgacaaac
      961 cgggcatgtt tggcagtaaa ttggcaccgt gtcacactgt ttcctgggat tcaagtatgc
     1021 aaccagaaca caggagaaga aaagctccag gatccctgtc cccatctgtc ctcttgatgt
     1081 gagagagact ctgagacttc ttccatcgca atgacctgta ttaaacacaa gccccccaag
     1141 caaaagaaga ggttgagttt gctgccagga ttcagatcag cccttcccag ggtctgcagg
     1201 tgtcacatga tcacagttca gcgggaggct ttccgtaccc acactggctg tagccacttc
     1261 agtccatctg ccctccagag gaggggtttc ttcctgattt ttagcaggtt tagaggctgc
     1321 agcttgagct acaatcagga gggaaattgg aaggattagc agcttttaaa aatgtttaaa
     1381 tattttgctt tgctaatgtg ctgatccgca ctaactcatc tttgcaaaag gaactgctcc
     1441 ctcggcgtgc cccagctggg gcctctgaag ggattcctca ctgtgggcag ctgccctgag
     1501 cttcaggcag cagtgttcat ctctggccag ttgtctggtt tccatgtatt ctaggccagg
     1561 taggcaacac agagccaagg cgggtgctgg aagccagacg gaacagtgtt ggggcaggaa
     1621 ggtggatgct gttgtcatgg agctgtggga gttggcactc tgtctgctgg tggccctctc
     1681 ggctcacatg ttcacagtgc agctcctggc agacttgggt tttctctttg gtggtttcta
     1741 aagtgcctta tctgcaaaca acttcttttc tccttcagga actgtgaatg gctagaagaa
     1801 ggagctcagt aaactagaag tccagggttg cttggtttac tggtttataa gaaatctgaa
     1861 agcacctctg acattccttt tattaactca cctctcagtt gaaagatttc ttctttgaaa
     1921 ggtcaagacc gtgaactgaa aaaagtgttg gcctttttgc gggaccagat ttttaagata
     1981 aaataaatat ttttacttct gtcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//

LOCUS       NM_018214               3468 bp    mRNA    linear   PRI 16-DEC-2004
DEFINITION  Homo sapiens leucine rich repeat containing 1 (LRRC1), mRNA.
ACCESSION   NM_018214
VERSION     NM_018214.3  GI:40217785
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3468)
  AUTHORS   Saito,H., Santoni,M.J., Arsanto,J.P., Jaulin-Bastard,F., Le
            Bivic,A., Marchetto,S., Audebert,S., Isnardon,D., Ad, Birnbaum,D.
            and Borg,J.P.
  TITLE     Lano, a novel LAP protein directly connected to MAGUK proteins in
            epithelial cells
  JOURNAL   J. Biol. Chem. 276 (34), 32051-32055 (2001)
  MEDLINE   21402985
   PUBMED   11440998
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AK021896.1, AU119761.1,
            AF332199.1 and AJ420513.1.
            On Dec 19, 2003 this sequence version replaced gi:33354254.
FEATURES             Location/Qualifiers
     source          1..3468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..3468
                     /gene="LRRC1"
                     /note="synonyms: LANO, FLJ10775, FLJ11834, dJ523E19.1"
                     /db_xref="GeneID:55227"
                     /db_xref="MIM:608195"
     CDS             642..1235
                     /gene="LRRC1"
                     /note="LAP (leucine-rich repeats and PDZ) and no PDZ
                     protein; leucine-rich repeat-containing 1;
                     go_component: membrane [goid 0016020] [evidence IEA]"
                     /codon_start=1
                     /product="leucine rich repeat containing 1"
                     /protein_id="NP_060684.3"
                     /db_xref="GI:40217786"
                     /db_xref="GeneID:55227"
                     /db_xref="MIM:608195"
                     /translation="MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLD
                     ANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS
                     FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE
                     NLLTYLPDSLTQLRRLEELDLGNNEIYNLNQLEPSYI"
ORIGIN      
        1 acttctgggg cagccgtgag cagcgggcac acgggcagcc acgaaagcag cagcgagggt
       61 ggtgcaaaca cctcataact acaccgaatc cagtagcgcc tggcgccccc ggcgcgcaag
      121 gccgcctcta ctccgcctca tctttgtccc aagtcctttc acagcctgcc ttcctcaaac
      181 ggcccgatgc gcccccgtct ttgccggagt aagcagaccg ccagcagccg gcccgcaggt
      241 cagtcgaccc tctctggatg caggtcgccg ggaaaacccg gagcggagca tccctcgggc
      301 cgggaaacgc cctcggcgcg cacccactgg cgcgcatgct cagtccgcgc ggcggctgcg
      361 agtaggaagc tccgcgcggc ggcgggggcg gcgacggcga ctggcgggtg ggagtggagg
      421 caccggctgg cgggcggggg tacagggacg gggcaggggc tcccgctcca ggttccttga
      481 agcacttccg accgcgaagc ccggcgcgag aagcgagcta acccaagagc caacaacgag
      541 cgcggagagg gcagcggact gagcggagcc gccggccaga gcgggctcgg agcccgggtc
      601 tccgccgctc gggacccggc taggcggcgg cgggggcggc gatgttccac tgcatccccc
      661 tgtggcggtg caaccgtcat gtggagagca tcgacaagcg ccactgctcg ctggtctacg
      721 tccccgagga gatctaccgc tatgcccgga gcctggagga gctgctgctg gacgccaacc
      781 agctccgcga gctgcccgag caatttttcc agctagtcaa attacgaaag cttggactta
      841 gtgataatga aattcagcgg ctccctccag aaatagcaaa cttcatgcag ctggtggaac
      901 tagatgtgtc tcgaaatgag attcctgaaa ttccagaaag catttcattc tgtaaagcac
      961 tgcaggtagc tgacttcagc ggaaacccac tgactaggtt gccagaaagc tttcctgaat
     1021 tacagaattt aacatgtctt tctgtaaatg acatctcact acagtctcta cctgaaaata
     1081 ttggcaatct ttataacctg gcttcactgg aactgagaga gaatcttctt acatatcttc
     1141 ctgactctct tacccagctg cgaagactag aagaacttga tttaggaaac aatgaaatat
     1201 ataatttgaa tcaattggag ccctcttaca tctaaaagat ctctggttgg atggaaatca
     1261 actgtcagaa ttacctcagg aaataggaaa tctgaagaac ctgctgtgtt tagatgtctc
     1321 tgaaaacagg ttggaaagac ttcctgaaga aatcagtggc ctgacttcat taacggattt
     1381 agtcatttcc cagaacttat tagaaacgat tccggatggc attggaaaac taaagaaact
     1441 gtcaatcttg aaggtggatc agaatagact cacacagttg cctgaagcag ttggggaatg
     1501 tgaaagtctc actgagttag ttcttacaga aaatcagctc ctgaccctgc ctaaaagcat
     1561 tggaaaacta aagaagttga gcaacttgaa tgcagacaga aataaattag tgtccttacc
     1621 aaaagagatc ggcgggtgct gcagcctcac tgtgttctgt gtacgtgaca acagactaac
     1681 tcggatacct gcagaggtgt cacaggcaac agaacttcat gtcctggatg tggcagggaa
     1741 caggttgctg catctacctt tatccctgac tgccttgaag ttgaaggctc tgtggctatc
     1801 tgacaaccag tcccagcccc tgcttacatt ccagacagac acagactaca ccacaggaga
     1861 gaagatttta acctgtgtct tacttcctca gctgccttct gaacctactt gtcaagagaa
     1921 tctgcctcgc tgtggtgcac tggagaactt ggtaaatgat gtctctgatg aagcctggaa
     1981 cgagcgtgct gtcaacagag tcagtgcgat ccgatttgtg gaggatgaga aagatgaaga
     2041 agacaatgag acgagaacac ttctaaggcg agccactcca cacccagggg agttaaagca
     2101 catgaaaaag acagtggaga atttacggaa tgacatgaat gctgctaaag gactggactc
     2161 aaacaaaaac gaggtcaatc atgccattga ccgagtgacc acttctgtgt agagtttcac
     2221 ctccaagttt tacctcctgt gtcttcctct gctgtcgaga cgttcctgtc tgcttcccgg
     2281 gagcctcacg tgctccttgt cctaaccagc ccccgcgcgc catcttcccg tggagtgtgg
     2341 ggaagctgct gtctcccagg aagtgcctta ctcatcccgc aaccagtcag cgcaccagtg
     2401 gtctcccggt gtgatttttt ttttttttaa tttcagttgt ttgtaataag tagaatacac
     2461 tactgtaaac atacgacctt tgtttttgtc ttatgttggg gtaaaggaaa gcaggaaggg
     2521 gaatttttat cctcctccct tccgtaaagt gctgggatat tttgaatccc ccaagttccc
     2581 ttggacctac tgatgagaga tagttttatg tatggggaaa aatggatact ttttaaacct
     2641 tttttggcag ctcagatggt gtaaatttta aaattttgta taggtatttc ataacaaaaa
     2701 tatgtatttc ttttttgtta ttttatcttg aaaacggtac atattttagt atttgtgcag
     2761 aaaaacaagt cctaaagtat ttgtttttat ttgtaccatc cacttgtgcc ttactgtatc
     2821 ctgtgtcatg tccaatcagt tgtaaacaat ggcatctttg aacagtgtga tgagaatagg
     2881 aatgtggtgt tttaaagcag tgttgcattt taatcagtaa tctacctggt ggatttgttt
     2941 ttaaccaaaa agatgaatta tcaatgattt gtaattatat cggttgattt tttttgaaaa
     3001 gatgaaccaa aggatttgac tgctaatatt ttattcctta cacttttttt ctgaataagt
     3061 ctctcataat gagtgcagtg tcagactgtg cctactctga tggtatgtgc catttgtaaa
     3121 ataaaataga gcagaaaaac acaaaaagag aacactggtt cagacattca gtgggcaagt
     3181 aaattatgga ctgcaaaata atgattttta ttcaagaaag ctttaaaagt tttatatcca
     3241 gatatacaac cacaataaag caaaataacc tactatcaaa atagaaatgt tgctatcttt
     3301 ataagtgcaa tttaatttgt aaatagagtt tgaatcaaag tatcacaaaa tactgcttca
     3361 agatttaatt ttaaatctgc taatttaagg gatattggga aaagttttgg tgtgtttctg
     3421 ttgatttctt ttttgtatgc tgtgataaaa gagaaatgaa aagtgaaa
//

LOCUS       NM_018226               2948 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens arginyl aminopeptidase (aminopeptidase B)-like 1
            (RNPEPL1), mRNA.
ACCESSION   NM_018226
VERSION     NM_018226.3  GI:54020717
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Horikawa,Y., Oda,N., Cox,N.J., Li,X., Orho-Melander,M., Hara,M.,
            Hinokio,Y., Lindner,T.H., Mashima,H., Schwarz,P.E., del
            Bosque-Plata,L., Horikawa,Y., Oda,Y., Yoshiuchi,I., Colilla,S.,
            Polonsky,K.S., Wei,S., Concannon,P., Iwasaki,N., Schulze,J.,
            Baier,L.J., Bogardus,C., Groop,L., Boerwinkle,E., Hanis,C.L. and
            Bell,G.I.
  TITLE     Genetic variation in the gene encoding calpain-10 is associated
            with type 2 diabetes mellitus
  JOURNAL   Nat. Genet. 26 (2), 163-175 (2000)
   PUBMED   11017071
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082975.1.
            On Oct 10, 2004 this sequence version replaced gi:20070295.
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2948
                     /gene="RNPEPL1"
                     /note="synonym: FLJ10806"
                     /db_xref="GeneID:57140"
                     /db_xref="MIM:605287"
     CDS             594..2078
                     /gene="RNPEPL1"
                     /note="argininyl aminopeptidase-like 1;
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: aminopeptidase activity [goid 0004177]
                     [evidence IEA];
                     go_function: metallopeptidase activity [goid 0008237]
                     [evidence IEA];
                     go_function: membrane alanyl aminopeptidase activity [goid
                     0004179] [evidence IEA];
                     go_process: proteolysis and peptidolysis [goid 0006508]
                     [evidence IEA]"
                     /codon_start=1
                     /product="arginyl aminopeptidase (aminopeptidase B)-like
                     1"
                     /protein_id="NP_060696.3"
                     /db_xref="GI:54020718"
                     /db_xref="GeneID:57140"
                     /db_xref="MIM:605287"
                     /translation="MSATRSAYMEEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRS
                     RVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMENPCL
                     TFIISSILESDEFLVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETY
                     GAAFTCLETAFRLDALHRQMKLLGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFV
                     YYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEF
                     ERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEPLDQAAASASAIDISKWRTFQT
                     ALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLHRVRR
                     FLESQMSRMYTIPLYEDLCTGALKSFALEVFYQTQGRLHPNLRRAIQQILSQGLGSST
                     EPASEPSTELGKAEADTDSDAQALLLGDEAPSSAISLRDVNVSA"
ORIGIN      
        1 ccagcgcgca gctcttccgc ctccgccacc tgcagctggg cctggagctg cggcccgagg
       61 cgcgcgagtt ggccggctgc ctggtgctcg agctgtgcgc gctgcggccc gcgccccgcg
      121 cgctcgtgct cgacgcgcac ccggctctgc gcctgcactc agccgccttc cgtcgcgccc
      181 ccgccgccgc cgccgagacg ccctgcgcct tcgccttctc cgcccccggg ccggggcccg
      241 cgccgccgcc cccgctgccc gccttccccg aggcgcccgg ctccgagccc gcctgctgtc
      301 cgctggcctt cagggtggac ccgttcaccg actacggctc ctcgctcacc gtcacgctgc
      361 cgcccgagct gcaggcgcac cagcccttcc aggtcatcct gcggtacacc tcgaccgacg
      421 cccccgccat ctggtggctg gacccagagc tgacctatgg ctgcgccaag cccttcgtct
      481 tcacccaggg ccactccgtg tgcaaccgct ccttcttccc gtgcttcgac acacctgccg
      541 tgaagtgcac ctactctgcc gtcgtcaagg cgccatcggg ggtgcaggtg ctgatgagtg
      601 ccacccggag tgcatacatg gaggaagaag gcgtcttcca cttccacatg gagcaccccg
      661 tgcccgccta cctcgtggcc ctggtggccg gagacctcaa gccggcagac atcgggccca
      721 ggagccgcgt gtgggccgag ccatgcctcc tgcccacggc caccagcaag ctgtcgggcg
      781 cagtggagca gtggctgagt gcagctgagc ggctgtatgg gccctacatg tggggcaggt
      841 acgacattgt cttcctgcca ccctccttcc ccatcgtggc catggagaac ccctgcctca
      901 ccttcatcat ctcctccatc ctggagagcg atgagttcct ggtcatcgat gtcatccacg
      961 aggtggccca cagttggttc ggcaacgctg tcaccaacgc cacgtgggaa gagatgtggc
     1021 tgagcgaggg cctggccacc tatgcccagc gccgtatcac caccgagacc tacggtgctg
     1081 ccttcacctg cctggagact gccttccgcc tggacgccct gcaccggcag atgaagcttc
     1141 tgggagagga cagcccggtc agcaaactgc aggtcaagct ggagccagga gtgaatccca
     1201 gccacctgat gaacctgttc acctacgaga agggctactg cttcgtgtac tacctgtccc
     1261 agctctgcgg agacccacag cgctttgatg actttctccg agcctatgtg gagaagtaca
     1321 agttcaccag cgtggtggcc caggacctgc tggactcctt cctgagcttc ttcccggagc
     1381 tgaaggagca gagcgtggac tgccgggcag ggctggaatt cgagcgctgg ctcaatgcca
     1441 caggcccgcc gctggctgag ccggacctgt ctcagggatc cagcctgacc cggcccgtgg
     1501 aggccctttt ccagctgtgg accgcagaac ctctggacca ggcagctgcc tcggccagcg
     1561 ccattgacat ctccaagtgg aggaccttcc agacagcact cttcctggac cggctcctgg
     1621 atgggtcccc gctgccgcag gaggtggtga tgagcctgtc caagtgctac tcctccctgc
     1681 tggactcgat gaacgctgag atccgcatcc gctggctgca gattgtggtc cgcaacgact
     1741 actatcctga cctccacagg gtgcggcgct tcctggagag ccagatgtca cgcatgtaca
     1801 ccatcccgct gtacgaggac ctctgcaccg gtgccctcaa gtccttcgcg ctggaggtct
     1861 tctaccagac gcagggccgg ctgcacccca acctgcgcag agccatccag cagatcctgt
     1921 cccagggcct gggctccagc acagagcccg cctcagagcc cagcacggag ctgggcaagg
     1981 ctgaagcaga cacagactcg gacgcacagg ccctgctgct tggggacgag gcccccagca
     2041 gtgccatctc tctcagggac gtcaatgtgt ctgcctagcc ctgttggcgg gctgaccctc
     2101 gacctcccag acaccacaat tgtgccttct gtgggccagg cctgccatga ctgcgtctcg
     2161 gctctggcca tgagctctgc ccaggcccac aagcccctcc cctgggctct cccaggcagg
     2221 gagaatgggg agagggacct ccttgtgtct ggcagagacc tgtggacctg gcctccccac
     2281 tcccagctct cttgcactgc aggccctggg gccagcccgc acacaccatg cctcctgtct
     2341 caacactgac agctgtgcct agccccggat gccagcacct gccaggtgcc gccccggggc
     2401 aagggcccca gcagccctat ggtgaccgcc acactgtgcc ttaatgtctg ccgggggccc
     2461 aggctgtgct gtccctgcag cacgcctcct tgcagggatc tgagccaccc tccccgcaca
     2521 gccctgcacc ccgcccctag ggttggcagc ctcagttggc ccctggcaga ggaacaagga
     2581 cacagacatt ccctcagtgt ggggggcagg ggacacaggg agaggatggt tgtccctggg
     2641 gagggccctc tggccccagg caaccttagc ccctcagaac agggagtccc aggacccagg
     2701 gagagtgtgg ggacaggaca gcctgtctct tgtagcttcc tggggtggga ggcacagggg
     2761 caaagcaata ccccagggaa agtgggaggt ggtgctggtg ctctctccag gcccaccatg
     2821 ctgggagagg cggccagagc ctggggcctc cagcctggga ctgctgtgat ggggtatcac
     2881 ggtgatggtc ccattaaact tccactctgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2941 aaaaaaaa
//

LOCUS       NM_018370               2835 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens hypothetical protein FLJ11259 (FLJ11259), mRNA.
ACCESSION   NM_018370
VERSION     NM_018370.1  GI:8922957
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2835)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK002121.1.
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..2835
                     /gene="FLJ11259"
                     /db_xref="GeneID:55332"
     CDS             88..486
                     /gene="FLJ11259"
                     /codon_start=1
                     /product="hypothetical protein FLJ11259"
                     /protein_id="NP_060840.1"
                     /db_xref="GI:8922958"
                     /db_xref="GeneID:55332"
                     /translation="MGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQ
                     WNSLSTCHIRMVISAVSCAAVIPMIVCASLISITKLEWNPREKDYVYHVVSAICEWTV
                     AFGFIFYFLTFIQDFQSVTLRISTEINGDI"
ORIGIN      
        1 gtacagaagc aaaatcaaac ctgctatttc agcactcctg tttttaactt ggtgtcttta
       61 gtgcttggat tggtgggatg tttcggaatg ggcattgtcg ccaattttca ggagttagct
      121 gtgccagtgg ttcatgacgg gggcgctctt ttggcctttg tctgtggtgt cgtgtacacg
      181 ctcctacagt ccatcatctc ttacaaatca tgtccccagt ggaacagtct ctcgacatgc
      241 cacatacgga tggtcatctc tgccgtttct tgcgcagctg tcatccccat gattgtctgt
      301 gcttcactaa tttccataac caagctggag tggaatccaa gagaaaagga ttatgtatat
      361 cacgtagtga gtgcgatctg tgaatggaca gtggcctttg gttttatttt ctacttccta
      421 actttcatcc aagatttcca gagtgtcacc ctaaggatat ccacagaaat caatggtgat
      481 atttgaagaa agaagaattc agtctcactc agtgaatgtc gcaggccatt tctaaaagtg
      541 ctacagagga cagacagggt tttgaggcca ccctgattat tgggatgcat ctgcagcaca
      601 tccaggactt gaatttcatt acgagttcct aatagttgta tttctaaaga tgtgtttcct
      661 agagaatgta cagccttatg acactgtagt gatgttttta taattttcta agtagatttt
      721 tttatattaa caaattcata tacagaaaaa ataaggtgtt acaaaaaatg gagagctctt
      781 atttttgtac agattctgtc gttttttttt atttgtgtga gatttatgga aatacactaa
      841 atgagtaatt caggttcagt acatttatta caaagtgaaa tcaggggata ttcatttgta
      901 aattttattc ttagtgaatg aactgtataa ttttttttat caggagagca cttataaaat
      961 tcaatttata aagatcatat acccaaatca taaagattta gttgatacat taacactaag
     1021 atactctgat ttttagcgaa ctaaacaaag tgcttctact gagaggcctt tataccacca
     1081 tgtacagtaa ctctaagtga atacggaaga ccttggtttt gaaattctgc caccttgttt
     1141 ctccctgctc atgaggtcgc accttttgct cttgctgcta attgcccatt cgtagtgggt
     1201 gtaatgccag gtggaatggt ttcaacaagt caggtgaaaa ccatccttta ttgttgctgg
     1261 cacaacttga tatatagtct gactcagaac tgaagctcac atctcaaatt catttcatgc
     1321 cagtaaatgt ggcaaagaga agaaaggccc aagagcgaga caagaagaat ggagaagggg
     1381 gcagccaaga agaacttctg ggttcagggt actgtttatt tgctccttct cttcatgcct
     1441 gtggctggat gtcccacaac actataagaa atataagtca agccctttgt gttaagcaag
     1501 aactacagac tccatctttt cacccaaatc atgaatgacc aataaaaagc aagttattcc
     1561 agaggaagaa gcagcccttg aaatgttaag gcttaggctt gaaaggtgaa gagcaggaat
     1621 tctctctttc aaatcctaga gcataaaccc atgtgtggcc aagtgagatc agccctcaag
     1681 ggcacatgcc aagggcagag cagcccatgt agacagcttc ggagggcatg ggggtgtagg
     1741 gagttcgggg tagctcctca ttaactattt gttgggtgag taaaggggtg aggctcagtg
     1801 gcaggtacct ctgcaatgac aagctgcctc ccctctatgt gtttagcata tgttattaga
     1861 acatgtccga cacccctacc gctgccattt gggcccttta ataaagccaa gtagagaaat
     1921 ctggcaataa aaggcaaatg taagcatgct ttctttaaga cgcatcataa atggttttct
     1981 ttaagtgaat ggaagagttt gacagagata cacctttgta agaaaacatt aagaatgctg
     2041 gctggctgtg gtggctcaca cctgtattcc cagcactttg ggaggcctag gcaggaggat
     2101 tgcttgagcc tgggacttcg agaccagact gggaaacatg gcaaaatccc atctctacaa
     2161 caaaaataca aaaattagcc aagtgcggtg gtgtgcctgt agtcctagtt acttgggagg
     2221 ctgaggtggg agaatcacct gagcccagga ggtggaggct gcagtgagcc atgccaatgc
     2281 actccagtct gggcaacaga gtgagaccct gtctcaaaaa taaataaata aataaatgaa
     2341 taaagagaat gctaatcatt tctgggttca ctgcgactca ctgtagtgct ggggatcccc
     2401 cttgtaacac tggaactgaa aggcagtgat gaaagctatg tcaagcattc attattctga
     2461 agaggaggag aaatgccaca tacctttccc atgggacctg tggtggaatg aatccatact
     2521 tctgcctcac ttcgagcaga cttttgttct cggcgctcct cacgatggag tttcatgctt
     2581 cattttcaca tctctctgca caattagatt gggagctcct tgagggcaga gtacgtgcct
     2641 taatctttat ctttgtaatg ccacaatgaa cagagtgcct cctggtacac tgtaggagct
     2701 taagaaatac tcactgaatg catgaatgaa tgaatgaaca aatgaaggaa tgactaagga
     2761 tgtttgtagt gctataatat agaatgggat ttactctgct ttaccagtta gtttcataat
     2821 aaacaaatag tctgt
//

LOCUS       NM_018561               3194 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens ubiquitin specific protease 49 (MGC20741), mRNA.
ACCESSION   NM_018561
VERSION     NM_018561.3  GI:34147686
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Quesada,V., D, Guti, Garabaya,C., Cal,S. and L.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem. Biophys. Res. Commun. 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC014176.2.
            On Aug 25, 2003 this sequence version replaced gi:21361748.
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21"
     gene            1..3194
                     /gene="MGC20741"
                     /note="synonym: USP49"
                     /db_xref="GeneID:25862"
     CDS             223..2145
                     /gene="MGC20741"
                     /note="go_function: hydrolase activity [goid 0016787]
                     [evidence IEA];
                     go_function: ubiquitin thiolesterase activity [goid
                     0004221] [evidence IEA];
                     go_function: cysteine-type endopeptidase activity [goid
                     0004197] [evidence IEA];
                     go_process: ubiquitin cycle [goid 0006512] [evidence IEA];
                     go_process: ubiquitin-dependent protein catabolism [goid
                     0006511] [evidence IEA]"
                     /codon_start=1
                     /product="ubiquitin specific protease 49"
                     /protein_id="NP_061031.2"
                     /db_xref="GI:21361749"
                     /db_xref="GeneID:25862"
                     /translation="MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHV
                     ACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAV
                     RGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFE
                     KSSRGQAKLEQRRQEEALERKKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRD
                     AGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQK
                     FRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNG
                     RASISRSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAF
                     RGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLL
                     SQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEA
                     LEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREK
                     IGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTE
                     GGACALLCGVGDTERG"
ORIGIN      
        1 cgcgccctgg tgacagctcg cgcgtgctga tgatggcgat tctttggatg ggaagagacc
       61 ttgaaaggac ctctagttta tcctgcaact ccagtcaata tcccacttaa atcattccag
      121 gtaatagaga agaggaaacc taaccaatga ctgtggaata atatggaaga agatggaaaa
      181 aacttgttta atgggttgag aaagtggcga cttctataag acatggatag atgcaaacat
      241 gtagggcggt tacggctcgc ccaggaccac tccatcctga accctcagaa gtggtgctgc
      301 ttagagtgtg ccaccaccga gtccgtgtgg gcctgcctca agtgctccca cgtggcctgc
      361 ggccgctata ttgaggacca cgccctgaaa cactttgagg agacgggaca cccgctagcc
      421 atggaagtcc gggatctcta cgtgttctgt tacctgtgca aggactacgt gctcaatgat
      481 aacccagagg gggacctgaa gctgctaaga agctccctcc tggcggtccg gggccagaaa
      541 caggacacgc cggtgagacg tgggcggacg ctgcggtcca tggcttcggg tgaggacgtg
      601 gtcctgccgc agcgcgctcc tcagggacag ccgcagatgc tcacggctct gtggtaccgg
      661 cgtcagcgcc tgctggccag gacgctgcgg ctgtggttcg agaagagctc ccggggccag
      721 gcgaagctgg agcagcggcg gcaggaggag gccctggagc gcaagaagga ggaggcgcgg
      781 aggcggcggc gcgaggtgaa acggcggctg ctggaggagc tggccagcac ccctccgcgc
      841 aagagtgcac ggctgctcct gcacacgccc cgcgacgcgg gcccggctgc ctcgcgcccc
      901 gccgccctcc ctacctcacg cagagtgccc gccgccacac tcaagctgcg tcgccagccg
      961 gccatggccc caggcgtcac gggcctgcgc aacctgggca acacctgcta catgaactcc
     1021 atcctccagg tgctcagcca cctccagaag ttccgagaat gtttcctcaa ccttgaccct
     1081 tccaaaacgg aacatctgtt tcccaaagcc accaacggga agactcagct ttctggcaag
     1141 ccaaccaaca gctcggccac ggagctgtcc ttgagaaatg acagggccga ggcatgcgag
     1201 cgggagggct tctgctggaa cggcagggcc tccattagtc ggagtctgga gctcatccag
     1261 aacaaggagc cgagttcaaa gcacatttcc ctctgccgtg aactgcacac cctcttccga
     1321 gtcatgtggt ccgggaagtg ggccctagtg tcgcccttcg ccatgctgca ctcagtgtgg
     1381 agcctgatcc ctgccttccg cggctacgac caacaggacg cgcaggaatt tctctgcgag
     1441 ctgctgcaca aggtgcagca ggaactcgag tctgagggca ccacacgccg gatcctcatc
     1501 cccttctccc agaggaagct caccaaacag gtcttaaagg tggtgaatac catatttcat
     1561 gggcagctgc tcagtcaggt cacatgtata tcatgcaatt acaaatccaa taccattgag
     1621 cccttttggg acctatccct ggaattccct gaacgctatc actgcataga aaaggggttt
     1681 gtccctttga atcaaacaga gtgcttgctc actgagatgc tggccaaatt cacagagaca
     1741 gaggccctgg aagggagaat ctacgcttgt gaccagtgta acagcaaacg acgaaaatcc
     1801 aatcccaaac cccttgttct gagtgaagct agaaagcagt taatgatcta cagactacct
     1861 caggttctcc ggctgcacct taaaagattc aggtggtctg gccgtaatca tcgagagaag
     1921 attggggtcc atgtcgtctt tgaccaggta ttaaccatgg aaccttactg ctgcagggac
     1981 atgctctcct ctcttgacaa agagaccttt gcctatgatc tctccgcagt ggtcatgcat
     2041 cacgggaaag ggtttggctc aggacactac acagcctatt gctacaacac agagggaggt
     2101 gcgtgcgctt tactctgtgg ggtgggggac acggaaaggg gttgatttgt ccacatttta
     2161 ttgttttcct tttatttcca tcccatggat tacctagagg gaaattacat acatcaaaaa
     2221 tccagtggaa agaattgtga aaattgggtt gggcgccgtg gctcacacct gtaatcctag
     2281 cgctttggga ggccgcggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggc
     2341 caacatggtt aaaccccgtc tctactaaaa tagtacaaaa attagccggg cgtggtggtg
     2401 ggcactggta atcccaggta ctcaagaggc tgaggcagga gaatcgcttg aacctgggag
     2461 gcagaggttg cagtgagcca agattatgcc actgcacttc agcctgggtg acagagcaag
     2521 actcttatct caaaaaaaat aaaaagaatt atgaaagttg gattcaaatt ttgggtatat
     2581 tactaagtaa caacatatgg ttgttctaag aattaaaagg aactgacatg taaaagtgct
     2641 tagaacagga cctaggccct gtgcaatggc tcacacctgt aattccaaca ctttgggagg
     2701 cagaggcggg aggattgctt gaggccgagg gttcaagact agcctgggca acatagcgag
     2761 actgcatctc tacaaaaaat ttaaaaatta tccaggtgta atggtgtgca cctgtgatcc
     2821 tagctacttg ggaggctgag gtgggagaat tgctcaagcc caggagtttg aagttgcaat
     2881 gagctatgat ttcaccactg cattctagcc tgggcaacag agtgagatcc tgactcaaat
     2941 aaataaataa gaagagcagt tgcctaccac atagtactta ttcagtcagt gttagaggat
     3001 attgtagtat tatcaaaagt attggttatt gataatatta ctgttttgtg gtaatgctac
     3061 ttctgcacac cccagtttcc ttcttggtta tgcagaaaca gtagaacctg tgtaacctca
     3121 aggagatatt gtatgaatct cactagccgc agcttataat aaagccgaga acatttaaaa
     3181 aaaaaaaaaa aaaa
//

LOCUS       NM_018719               2874 bp    mRNA    linear   PRI 15-OCT-2004
DEFINITION  Homo sapiens transcription factor RAM2 (RAM2), mRNA.
ACCESSION   NM_018719
VERSION     NM_018719.2  GI:31542536
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC039823.1.
            On Jun 9, 2003 this sequence version replaced gi:14149721.
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..2874
                     /gene="RAM2"
                     /note="synonym: DKFZp762L0311"
                     /db_xref="GeneID:55536"
     CDS             85..1449
                     /gene="RAM2"
                     /codon_start=1
                     /product="transcription factor RAM2"
                     /protein_id="NP_061189.2"
                     /db_xref="GI:31542537"
                     /db_xref="GeneID:55536"
                     /translation="MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESC
                     DSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMV
                     VESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKN
                     SSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRT
                     MNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSAR
                     PPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLE
                     NVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDV
                     RSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKEL
                     VEDN"
ORIGIN      
        1 gggcgttctt ggtgcgccgg gccgtggtga gtccgggctc ccgtggccgc gtgctgggag
       61 gagactggag cccggttagg aagaatggag ttggcgactc gctaccagat ccctaaagaa
      121 gtggctgaca tctttaacgc ccccagtgat gatgaagagt ttgttggctt ccgagatgat
      181 gttcccatgg aaaccctctc gtcagaggag agctgcgata gttttgactc actagagtca
      241 gggaaacagc aggatgtgcg ctttcattcc aaatacttca cagaagagct aagaagaatt
      301 tttatagagg acactgactc agagactgag gattttgcag gatttacgca gagtgatctg
      361 aatggaaaga ctaacccaga agtaatggtc gtggagtcag atttgagtga tgatggcaaa
      421 gcatctttgg tgagcgagga agaggaagat gaagaagaag ataaggctac ccctagaaga
      481 agcaggtcta gaagaagtag tattggtctt cgagtagcct ttcagttccc caccaagaag
      541 ctggccaaca aaccagataa aaacagttct tccgagcagt tgttttctag cgcacgctta
      601 cagaatgaga aaaaaacaat tcttgaaaga aagaaagact gtagacaggt gatacaaagg
      661 gaagattcta cctctgagtc tgaggatgac tctcgggatg agagccagga gagttcagat
      721 gctttgctga aaaggaccat gaacatcaag gagaacaaag ccatgcttgc ccagttattg
      781 gcggaattga actcgatgcc agatttcttc ccagtacgaa ccccaacctc agcttctagg
      841 aagaagacag tgaggcgggc cttctcggag ggacagatca cgcggcgtat gaacccaacc
      901 cggagtgcgc ggcctcctga gaagtttgct ctagagaact tcactgtctc agccgctaaa
      961 tttgcggaag agttttacag cttccgaaga aggaagacaa ttggggggaa atgccgggag
     1021 tacagacgac gtcaccgtat atcttctttt cggccagtgg aggatatcac cgaagaggac
     1081 ttagaaaatg ttgccataac tgttcgagat aaaatctatg ataaagttct gggtaacacg
     1141 tgccatcagt gtcgacaaaa gaccatcgac accaagacag tgtgtcggaa ccagggttgc
     1201 tgtggtgtgc gaggacagtt ctgtggacca tgcctgcgga accgctatgg ggaggatgtc
     1261 agatcggcat tgctggaccc ggattgggtg tgtcccccct gtcgtgggat ctgcaattgc
     1321 agctactgtc ggaagcgtga cggccgctgt gccacaggaa tcctcattca tctggccaag
     1381 ttttatggtt atgacaatgt taaggaatat ctggagagct tacaaaagga gctggtagaa
     1441 gacaattaag aggaaaacaa acagaaccag ccacctcacc atagagtact ccaacaagac
     1501 atgcatacca ttggtgccta agattttttt acagttgtgt ttttatacag aaattctttg
     1561 tagaaattac tattttttgt taaagattgt ttatatgctt acaaagattt ctcaggaaga
     1621 cagcagagca gaggaatcta tatagatgta tgcacagacc tgtctgtatg ctgaactttg
     1681 ttaaaaatat ctgccagtta ttaaaaagca cagttgaaat ggggtggggt taaagttcag
     1741 gtaagtaagt tagagagaaa acattgtatg atcagctcct gcacttgatc tatctttggc
     1801 ttcccaaaca gtaactcact ccaggccaag tgtgccttag cacgagtgac cacagtttaa
     1861 tagaccacac acatcgttta acctgctctt ggtcattgga aatttacact gaacaaagtg
     1921 caattaactg tagaacagtt ttatttttat taaaacttga ctgaacaaaa ggggaccatc
     1981 aacattgtag acactggagg ccttacagag tgctagcctc ttccttcagg actcacctgg
     2041 ggcctgctgc ttttatattt tgaaagagtt taagggctaa taatttaatt tgttgtttgt
     2101 taaaaattaa aatctccgtt ctttccggct gcattgcttt tgcatgttca catatgatgt
     2161 acttttatga tgtacttttt tttttttgag atggagtctt gttctgttgc ccaggaggga
     2221 gtgcagtggt gcaacctcgg ctcactgcaa cctttgcctc ctaggttcaa gtgattctcc
     2281 tacctcctga gtaactggga ttacagtcgt gtgccaccac gctcagccct gagttagttt
     2341 ctagtatttt tttctgactt tcactctaag gatagcgttg aaaaaagaat gcacgtgtga
     2401 gttactaaaa agtcagaata atgtgcatgg gaacagtgca gcaacatgct agaaaatcct
     2461 cactgcactc cagcagaggc tagaggaatg ccagtgttac cttacgcttc tagaagcaga
     2521 gccactccag ccagaaccca ttttgcagtc ttctcttcgc tcttcagcct gaaggtccag
     2581 atgtagctgg ggcctctcag tttggttcta tacacagggc actcgtaggt ctgtttggtt
     2641 tcttgtctgt ccacgggggt ggcttttgca aagatgaccg gcatagggca tgccagctcc
     2701 ttgagacggg cttcaacaat ggttcctgct tgggtgtccc agcgggcgcc tatggcaaaa
     2761 acacagcggt tgcaattgtg tggcagcttg ctactaatga taatgatcaa gttgtttgat
     2821 gcaataaaca ttcaacattc tggttttgtc aaaaaaaaaa aaaaaaaaaa aaaa
//

LOCUS       NM_018845               1316 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens stromal cell protein (LOC55974), mRNA.
ACCESSION   NM_018845
VERSION     NM_018845.1  GI:10047123
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
  MEDLINE   22388257
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF126023.1.
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1316
                     /gene="LOC55974"
                     /note="synonym: SCP"
                     /db_xref="GeneID:55974"
     CDS             61..726
                     /gene="LOC55974"
                     /note="RP11-540D14.5;
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_function: molecular_function unknown [goid 0005554]
                     [evidence IEA]"
                     /codon_start=1
                     /product="stromal cell protein"
                     /protein_id="NP_061333.1"
                     /db_xref="GI:10047124"
                     /db_xref="GeneID:55974"
                     /translation="MEAGGFLDSLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVRF
                     LPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRKRVVLLQTA
                     TLLGVLLLGYGYFWLLVPNPEARLQQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCL
                     SYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKYPQEQDRNYWL
                     LQT"
ORIGIN      
        1 ggtaggtccc ggcaaccgca gctcgcggcg ggcgctgggc gggatccgac tctagtcgta
       61 atggaggcgg gcggctttct ggactcgctc atttacggag catgcgtggt cttcaccctt
      121 ggcatgttct ccgccggcct ctcggacctc aggcacatgc gaatgacccg gagtgtggac
      181 aacgtcagat tcctgccctt tctcaccacg gaagtcaaca acctgggctg gctgagttat
      241 ggggctttga agggagacgg gatcctcatc gtcgtcaaca cagtgggtgc tgcgcttcag
      301 accctgtata tcttggcata tctgcattac tgccctcgga agcgtgttgt gctcctacag
      361 actgcaaccc tgctaggggt ccttctcctg ggttatggct acttttggct cctggtaccc
      421 aaccctgagg cccggcttca gcagttgggc ctcttctgca gtgtcttcac catcagcatg
      481 tacctctcac cactggctga cttggctaag gtgattcaaa ctaaatcaac ccaatgtctc
      541 tcctacccac tcaccattgc tacccttctc acctctgcct cctggtgcct ctatgggttt
      601 cgactcagag atccctatat catggtgtcc aactttccag gaatcgtcac cagctttatc
      661 cgcttctggc ttttctggaa gtacccccag gagcaagaca ggaactactg gctcctgcaa
      721 acctgaggct gctcatctga ccactgggca ccttagtgcc aacctgaacc aaagagacct
      781 ccttgtttca gctgggcctg ctgtccagct tcccaggtgc agtgggttgt gggaacaaga
      841 gatgactttg aggataaaag gaccaaagaa aaagctttac ttagatgatt gattggggcc
      901 taggagatga aatcactttt tattttttag agattttttt ttttaatttt ggaggttggg
      961 gtgcaatctt tagaatatgc cttaaaaggc cgggcgcggt ggctcacgcc tgtaatccca
     1021 gcactttggg aggccaaggt gggcggatcg cctgaggtca ggagttcaag accaacctga
     1081 ctaacatggt gaaaccccat ctctactaaa aatacaaaat tagccaggca tgatggcaca
     1141 tgcctgtaat cccagatact tgggaggctg aggcaggaga attgcttgaa cccaggaggt
     1201 ggaggttgca gtgagctgag atcgtgccat tgtgatatga atatgcctta tatgctgata
     1261 tgaatatgcc ttaaaataaa gtgttcccca cccctgaaaa aaaaaaaaaa aaaaaa
//

LOCUS       NM_019027               4020 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens RNA-binding protein (FLJ20273), mRNA.
ACCESSION   NM_019027
VERSION     NM_019027.1  GI:9506670
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK000280.1.
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p13-p12"
     gene            1..4020
                     /gene="FLJ20273"
                     /db_xref="GeneID:54502"
     CDS             240..1814
                     /gene="FLJ20273"
                     /codon_start=1
                     /product="RNA-binding protein"
                     /protein_id="NP_061900.1"
                     /db_xref="GI:9506671"
                     /db_xref="GeneID:54502"
                     /translation="MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGY
                     SMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRTYELRL
                     MMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPK
                     MKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGR
                     IQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVER
                     VKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGG
                     GAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKVAIPAIGAQYSMFPAAPA
                     PKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPIT
                     PVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAVYGGYAGYIPQAF
                     PAAAIQVPIPDVYQTY"
ORIGIN      
        1 gtcaattgcc ctttagtccc aggactaacc ggaagcttct gcaacaggag gacattgaaa
       61 ataagatgga acccatccac ataaggattt gcctcaaagg gcactgcaaa aattgaacag
      121 aggaatccca aggaagctgc ctgaatttgc ctgtatactc tcgttctgcg acttataaag
      181 gaccagacaa atcaaattag tggttttggt ttccgccagc tgtggatgcc tttgacatta
      241 tgaccgcaga ggattccacc gcagccatga gcagtgactc ggccgccggg tcctcggcca
      301 aggtgcccga gggcgtggcg ggcgcgccca acgaggcagc actgctggcg ctgatggagc
      361 gcacgggcta cagcatggtg caagagaacg ggcagcgcaa gtacggcggc ccaccgcccg
      421 gctgggaggg cccgcacccg cagcgtggct gcgaggtctt cgtgggcaag atcccgcgcg
      481 acgtgtacga ggacgagctg gtgcccgtgt tcgaggccgt gggccgcacc tacgagctgc
      541 gcctcatgat ggactttgac ggcaagaacc gcggctacgc cttcgtcatg tactgccaca
      601 agcacgaggc caagcgcgca gtgcgtgagc tcaacaacta cgagatccgc ccgggccgcc
      661 tgctcggcgt gtgctgcagc gtggacaact gccgcctctt catcggcggg atccccaaga
      721 tgaagaagcg cgaggaaatc ctggaggaga ttgccaaggt caccgagggc gtgctggacg
      781 tgatcgtcta cgccagcgcg gccgacaaga tgaagaaccg cggcttcgcc ttcgtggagt
      841 acgagagcca ccgcgcggct gccatggctc gccgcaagct catgcctggc cgcatccagc
      901 tgtggggcca ccagatcgcc gtggactggg ccgagcctga gatcgacgtg gacgaggacg
      961 tgatggagac cgtgaagatc ctctacgtgc gcaacctcat gatcgagacc accgaggaca
     1021 ccatcaagaa gagcttcggc cagttcaacc ccggctgcgt ggagcgcgtc aagaagatcc
     1081 gcgactacgc cttcgtgcac ttcaccagcc gcgaggatgc cgtgcatgcc atgaacaacc
     1141 tcaacggcac tgagctggag ggctcgtgcc tggaggtcac gctggccaag cccgtggaca
     1201 aggagcagta ctcgcgctac cagaaggcag ccaggggcgg cggcgcggct gaggcagcgc
     1261 agcagcccag ctacgtgtac tcctgcgacc cctacacact ggcctactac ggctacccct
     1321 acaacgcgct cattgggccc aacagggact actttgtgaa agtagccatc cctgccattg
     1381 gggctcagta ttccatgttt ccagcagctc cagcccctaa aatgattgaa gatggcaaaa
     1441 tccacacagt ggagcacatg atcagcccca ttgctgtgca gccagaccca gccagtgctg
     1501 ctgccgccgc agccgcggcc gcagccgccg cagccgctgt cattcccact gtgtcgacgc
     1561 caccaccttt ccagggccgc ccaataactc cagtatacac ggtggctcca aacgttcaga
     1621 gaattcctac tgccgggatc tacggggcca gttacgtgcc atttgctgct ccagctacag
     1681 ccacgatcgc cacactacag aagaacgcgg cagccgcggc cgccgtgtat ggaggatacg
     1741 caggctacat acctcaggcc ttccctgctg ctgccattca ggtccccatc cccgacgtct
     1801 accagacata ctgaggctgg tgaccagcac gaagacagac cacacaaaca ccactgaagg
     1861 aacgcttgac tatttatgaa gaaggaacat gttggattca cacatgcaac ctgaaagtga
     1921 agaatgttag cagatttatt tctgaattat tttatataca tgaagttttc actagttttt
     1981 taagactatt ttcaacttag catgcctacg ttcatacatt tccaaaagac ttgcaatggt
     2041 tcgtgccttc attccatctt ttaaaaattt gtatgctgta ctacatttgt atagaggttt
     2101 ttgttgttgt ttttttaagg atatattttc agtatgaagg ttattttctt aacttctgca
     2161 ctccagagat ttctattttg tagtaccttc aataatatat caactatata ttaaaaaagc
     2221 acacttgagg agctagggaa ctattttgaa aaatatatac aatatttaaa gatacaaaca
     2281 gtagtgctta aaaatactac ataaagcatt attttaaagg ttatactgga aagtgcaatt
     2341 ttaaaatgag taaaacctct gtatttctgc tggcattaag ggttgatggt gttaccatgt
     2401 atcatcatgg cggtactatt ttttaaaaga aattaaacac tggatctctc cttaagccaa
     2461 cattgaaaag acttgccgca cttctgagtc caaacactgg aaagctctcc ttgccaccgt
     2521 tagccggggc tcattctcca tgtgccttag ccttaaacat gcccccactc ccacatctct
     2581 caccctgtcc cctcctcccc agattcccaa tcccaccgca atgtttggca agcctaggac
     2641 tgataagtag ctctgataga ggagctggtg gcttttatac ttcttcctgg gtttttgttg
     2701 gggtttgttg tttcgttgtt ttttgttttt tttttgtttg gttggggaag tattgtcttc
     2761 tacgtgtgct attttcagta gcagagtaag cacaaggttt taatcgagtt gcataagaca
     2821 cctttgcata gctatttaat tgcccaatgt aaaactttaa tgccatttct aatgctttta
     2881 ttcatttttg aagtatgagt ttgtagggac aaagaatgta tgttatcgta gacaagaccc
     2941 ccagagactc ttttcagcag aaagttatgc ttctagttgc cttaccatgt ttcttgcaaa
     3001 actgtccatg gtcctcaagg gtgttggaaa cattatgttt attaaatggg cctctcttcc
     3061 tttgctgtgc acttgatggg tgaactggat tggggtgtgc acatccagga ggaggaggag
     3121 agacctgtag aagtttaaag atagtttgta aatatcttct aatgcttgtt tttagtcctt
     3181 ttatgttgga gaagttcatg gtatgtagtt taatgcaaaa tgaaaccatt ttatttcaat
     3241 gttattaaaa aggtttgttt tattaggaag ttaatgtatt gttgcagtgt tttgtgcctg
     3301 tttaaaggct tttgtttagc agagtgaatg taaaatacag taaaatgtta agattgtcat
     3361 ctacttttta aaaaaaaata tcaacttgga attgtttttt aaaggctcaa tcaaggaagt
     3421 gaggtgtgca ataaggtagc aagtaaaacg cagttgcgtt tttatgtcat gttagagatc
     3481 catacaattt tccactcacg ggatttttgt tgatggctga attcttgtgg attcataaga
     3541 ggatcatgcc cttagcaagt acttttgttt tgttttaaat taagagattc ccaaatgcct
     3601 ttttccccct catcttgaaa tgagatgagt ttttatgtgt aagcaatatt tatttaacta
     3661 ttctataaaa ttattgagtg cctactgagg cctttaagca ccgctaacat tcctttccat
     3721 cattcttttg aatgacataa aataattgtg caatgttcct gatgatgtac cccacagctg
     3781 cattcaaact caaatctgtg ggaatgagtg actcgaccaa atgtaattcg gatcagatcc
     3841 tcatcccctg actgtgtgaa aaaagtactc tccttctagt gaaggattgt cacagagttt
     3901 cactggatga aactatgacc cagtattctt actgtatttt acatgtgcct gtaaattatt
     3961 ttgccgaaat aagaagaaga agaggaagaa agaacagtag aaaaaaaaaa taaaaaaaaa
//

LOCUS       NM_019054               3402 bp    mRNA    linear   PRI 22-JAN-2005
DEFINITION  Homo sapiens family with sequence similarity 35, member A (FAM35A),
            mRNA.
ACCESSION   NM_019054
VERSION     NM_019054.1  GI:12963480
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK022978.1.
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..3402
                     /gene="FAM35A"
                     /note="synonyms: MGC5560, bA163M19.1"
                     /db_xref="GeneID:54537"
     CDS             115..2622
                     /gene="FAM35A"
                     /codon_start=1
                     /product="family with sequence similarity 35, member A"
                     /protein_id="NP_061927.1"
                     /db_xref="GI:12963481"
                     /db_xref="GeneID:54537"
                     /translation="MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYS
                     QHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKDDFVRSVSETQNI
                     ESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICG
                     KNFNTNLFQLGHKCAAVLDLVCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNA
                     VDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNVNMETEP
                     KASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLE
                     EHTGSQELFSSEDELPPNEIRIELCSSGILCSQLNTFHKSAIKRSCTSEDKVGQSEAL
                     SRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLS
                     PCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLT
                     DVVIHEDQWIGETVLQSTFSSQLLNLGSYSSIQPEEYSSVVSEVVLQDLLAYVSSKHS
                     YLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVM
                     LTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIALNAHS
                     SLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPLTMKKIYYRPALMTAIDG
                     RHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVL
                     KIQSLFVLDENSYPLQQDFSLLDFYPDIVKHGANARL"
ORIGIN      
        1 acgggcggcc ggatttgccc ggaggccgca cccgcctccg gcggggctct cagtgaaaaa
       61 tgtactctga cctgaatcct gaattttcct tgatggtcaa aagattaaga aatcatgagt
      121 ggaggatctc aagtccacat tttttggggt gctccaattg ctccactgaa aatcacagta
      181 tcagaagaca cagcttcttt aatgtctgtt gctgacccct ggaaaaaaat tcagctttta
      241 tacagtcaac attctttata tctgaaggat gaaaaacagc acaaaaatct tgaaaactat
      301 aaagtcccag aatctattgg ttctccagat cttagtggtc atttcttagc aaactgtatg
      361 aatagacatg ttcatgtgaa agatgacttt gtacgttctg tttctgaaac acagaatata
      421 gaatcccaga agattcactc ctctagactg agtgatataa ctagctctaa tatgcaaata
      481 tgtggattta aaagcacagt tccgcatttc accgaagaag aaaagtatca aaagcttctc
      541 agtgaaaata aaattagaga tgaacagcct aaacatcagc cagatatatg tggtaagaac
      601 tttaacacaa atttgtttca gttgggccat aaatgtgcag ctgtgttgga tttggtttgt
      661 agtactgaaa aaattaatat agggcctgaa gtggtacaaa gagagtgtgt gccaacagaa
      721 tatcatgaaa tacaaaacca gtgtttggga ttattttcct cgaacgcagt agataagtca
      781 aggtctgaag cagcagttag gaaggtctca gaccttaaaa tatcaactga tacagaattt
      841 ctcagtataa ttacctccag ccaggttgct tttttagctc aaaagaaaga taaaaggcgg
      901 agtcctgtaa ataaagggaa tgtaaacatg gagactgaac caaaggcaag ttacggggag
      961 ataagaatac ctgaagagaa ttcgattcag cttgatggtt ttacagaagc atatgaaagt
     1021 ggacaaaacc aagcatattc ccttgaactt tttagtcctg tttgtcctaa aacagaaaat
     1081 agccgcattc acataaactc tgataaaggt cttgaagaac atacaggatc tcaagaactt
     1141 ttcagttctg aagatgaact gccaccaaat gagatacgta ttgagttgtg tagctcagga
     1201 atactgtgtt cccaactaaa taccttccac aaaagtgcta ttaaaagaag ctgtacctct
     1261 gaagataaag tgggccagtc tgaagctcta tctagagtcc ttcaagtagc taagaaaatg
     1321 aagttgattt ctaatggagg agattctgct gtagaaatgg atcggagaaa tgtgtctgaa
     1381 tttaagagta ttaaaaaaac atcattaata aaaaactgtg attctaaaag ccagaagtat
     1441 aattgtttag tcatggtgct atctccatgc catgtgaagg aaataaacat aaaattcgga
     1501 ccaaattctg gctctaaagt gcctttagca acagttacag taattgatca atcagaaact
     1561 aagaagaagg tttttctgtg gaggactgca gcattttggg catttacagt gtttcttgga
     1621 gatataattt tactcacaga tgttgttatt catgaggacc aatggattgg cgagacagta
     1681 ctacaatcaa catttagcag tcagttatta aatcttggga gttattcatc tattcagcct
     1741 gaagaatatt ccagtgtagt tagtgaagtt gtacttcaag acttactggc atatgtgtcc
     1801 tcaaaacatt cctacctcag agatcttcct ccgaggcagc ctcagagggt gaacagtata
     1861 gactttgtag aattggagca ccttcaacct gatgtattag tccacgcagt actaagagtt
     1921 gttgatttca ctatactgac agaggcagta tacagttata gaggacagaa gcagaaaaaa
     1981 gttatgttaa cagtggaaca ggcccaagat caacattatg cgcttgtatt atggggtcct
     2041 ggagcagcct ggtaccctca acttcaaagg aaaaaaggag tggttctgat taaagcccag
     2101 atttcagagc tggcatttcc tattacagca tctcagaaga tagcgctaaa tgctcacagt
     2161 tctctgaaga gtattttttc ttctcttccc aacatcgtat atactggctg tgcaaaatgt
     2221 ggattggaac tagaaacaga tgagaacagg atctacaaac aatgttttag ctgcttgcca
     2281 cttactatga agaaaatata ttataggcca gcgttaatga ctgccattga tggaagacat
     2341 gatgtttgta tccgtgtaga atcaaagctg atagagaaga ttcttctcaa catttctgca
     2401 gactgcctca acagagtgat agttccttcc tcagagatca cctatgggat ggtcgtggca
     2461 gacctgttcc actccttgtt ggcagtcagc gcagaacctt gtgtattaaa gattcagagc
     2521 ctttttgtgt tagatgaaaa cagctatcca ttacaacaag atttctccct cctggatttt
     2581 tatcctgaca ttgtaaagca tggagccaat gcccgtctct gaggccagag gaagaaattg
     2641 caggcatttc aaggaagaag tactgaaatg atttgtcttt tgaaataaat gaatgacagg
     2701 gcttttgctt tggatttttt atgaaatata ttttataaag agaattgcac tagatatata
     2761 aattaaaact tttttctaag aaaatcctgt gaggtttaaa aagattgttt ttgtcttttg
     2821 gtttcttcct ttctcctgga gaaatgatct accagtcaag gcaatatgta gcagatccct
     2881 gggaattaaa ggtttgccca tttgttcact gtatttagtc cctgctacat tccaggcatt
     2941 gtactaagta tggggaacca cagagaagac attccctcag aaactgctgc agtgctttcg
     3001 cttatcccta cctaaaaaac cgtcaatgtg aaatcatttc cttgattata actataatga
     3061 taatggatta gtttatataa acctatgttt agacaagttc aagacaagcg tgtctttcta
     3121 taaaaagtat tgaaaatgaa ggaaatgaga tcatgtttca atttattaaa gcagggaaga
     3181 gcgttctgtg gttagttcgt gtctaggatt tgagtgcctt actgaatgca tttaccagca
     3241 aacatgtagc aatctgttct ctcattgtga ttgtggaaga agctcatgta aaatgatagt
     3301 cattaatgag gaagtatggc gtggtactta ttctgtaagt tcagagtatg ctgagtgtta
     3361 atagattatc atattgcctg aaaataaatt catgatgaca tg
//

LOCUS       NM_019895               2820 bp    mRNA    linear   PRI 18-DEC-2004
DEFINITION  Homo sapiens chromosome 3 open reading frame 4 (C3orf4), mRNA.
ACCESSION   NM_019895
VERSION     NM_019895.1  GI:11096339
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
  MEDLINE   22887296
   PUBMED   12975309
REFERENCE   2
  AUTHORS   Fayein,N.A., Stankoff,B., Auffray,C. and Devignes,M.D.
  TITLE     Characterization of tissue expression and full-length coding
            sequence of a novel human gene mapping at 3q12.1 and transcribed in
            oligodendrocytes
  JOURNAL   Gene 289 (1-2), 119-129 (2002)
  MEDLINE   22032963
   PUBMED   12036590
REFERENCE   3
  AUTHORS   Pi, Mariage-Samson,R., Fayein,N.A., Matingou,C., Eveno,E.,
            Houlgatte,R., Decraene,C., Vandenbrouck,Y., Tahi,F., Devignes,M.D.,
            Wirkner,U., Ansorge,W., Cox,D., Nagase,T., Nomura,N. and Auffray,C.
  TITLE     The Genexpress IMAGE knowledge base of the human brain
            transcriptome: a prototype integrated resource for functional and
            computational genomics
  JOURNAL   Genome Res. 9 (2), 195-209 (1999)
  MEDLINE   99148144
   PUBMED   10022985
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AJ270952.1.
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p11-q11"
     gene            1..2820
                     /gene="C3orf4"
                     /note="synonyms: HSPC174, PRO6000, GENX-3745,
                     DKFZP564P0462"
                     /db_xref="GeneID:56650"
     CDS             881..1642
                     /gene="C3orf4"
                     /function="unknown"
                     /note="go_component: integral to membrane [goid 0016021]
                     [evidence IEA]"
                     /citation=[2]
                     /codon_start=1
                     /product="chromosome 3 open reading frame 4"
                     /protein_id="NP_063948.1"
                     /db_xref="GI:11096340"
                     /db_xref="GeneID:56650"
                     /translation="MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSS
                     DLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDV
                     VTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLC
                     ACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCL
                     ACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA"
     sig_peptide     881..940
                     /gene="C3orf4"
                     /citation=[2]
     polyA_signal    2795..2800
                     /gene="C3orf4"
ORIGIN      
        1 gggattttta aaaaatcaaa atacaaatcc aactttttga gttttcgttg tcattgctct
       61 tatctttcct gagtcacttc ccattttcca aactcagcaa ccccagtttg cgagtctggt
      121 ttcatgaacc tttgtaaggt gtttggtgcg gtcacrgtgt atacttgccg tgtagtattt
      181 gactcagcgc gatctgcctt gagtcatttt accgcggcca tttactactg ccgttgagcc
      241 ctgtccacgc cttgggagtg ttgatatgtt gagagttttc tgtctggctg rggagggatc
      301 atttagtttt tgcggacgta tgttgcactg aggatttagg gagagagcaa gatttctgtt
      361 gaggaggttc agaagtataa ggaatcggga gagtagatag gagtgaagca tttggcagcg
      421 taaagaagct tggcttagct ttaatggatt agggagagat tgctatctag cattattaca
      481 tgttattgtt ctctttgcta ttttatacac ctagaacaac ctttccctcg gggttaacaa
      541 acatcttcaa ctctgttttc tgtatggctc ctgactctta cctttgtttt aggaggcttc
      601 cctcttcaga ggaaactggg agaagccaat ttccactgct tctttttcct gtgccttttt
      661 aacactcaaa cccagaacac ttaatcctct gcagctcgtg caaaaattca gtctgtaatt
      721 taaaatgtgt gcacggtaca ctgctgacca tgggcatgtc tattgtttgt atctgtaatg
      781 tgtatgtcca tttcagtgtt gtctgtttta gtatgcaggt gatagactag agaacaagac
      841 ctctgtctcc gtagcatcct ggagcagtct gaatgccaga atggataacc gttttgctac
      901 agcatttgta attgcttgtg tgcttagcct catttccacc atctacatgg cagcctccat
      961 tggcacagac ttctggtatg aatatcgaag tccagttcaa gaaaattcca gtgatttgaa
     1021 taaaagcatc tgggatgaat tcattagtga tgaggcagat gaaaagactt ataatgatgc
     1081 actttttcga tacaatggca cagtgggatt gtggagacgg tgtatcacca tacccaaaaa
     1141 catgcattgg tatagcccac cagaaaggac agagtcattt gatgtggtca caaaatgtgt
     1201 gagtttcaca ctaactgagc agttcatgga gaaatttgtt gatcccggaa accacaatag
     1261 cgggattgat ctccttagga cctatctttg gcgttgccag ttccttttac cttttgtgag
     1321 tttaggtttg atgtgctttg gggctttgat cggactttgt gcttgcattt gccgaagctt
     1381 atatcccacc attgccacgg gcattctcca tctccttgca ggtctgtgta cactgggctc
     1441 agtaagttgt tatgttgctg gaattgaact actccaccag aaactagagc tccctgacaa
     1501 tgtatccggt gaatttggat ggtccttctg cctggcttgt gtctctgctc ccttacagtt
     1561 catggcttct gctctcttca tctgggctgc tcacaccaac cggaaagagt acaccttaat
     1621 gaaggcatat cgtgtggcat gagcaagaaa ctgcctgctt tacaattgcc atttttattt
     1681 ttttaaaata atactgatat tttccccacc tctcaattgt ttttaatttt tatttgtgga
     1741 tataccattt tattatgaaa atctatttta tttatacaca ttcaccacta aatacacact
     1801 taataccact aaaatttatg tggtttactt taagcgatgc catctttcaa ataaactaat
     1861 ctaggtctag acagaaagaa atggatagag acttgacaca aatttatgaa agaaaattgg
     1921 gagtaggaat gtgaccgaaa acaagttgtg ctaatgtctg ttagactttt cagtaaaact
     1981 aaagtaactg tatctgttca actaaaaact ctatattagt ttctttggga aacctctcat
     2041 cgtcaaaact ttatgttcac tttgctgttg tagatagcca gtcaaccagc agtattagtg
     2101 ctgttttcaa agatttaagc tctataaaat tgggaaatta tctaagatca ttttccctaa
     2161 gcattgacac atagcttcat ctgaggtgag atatggcagc tgtttgtatc tgcactgtgt
     2221 ctgtctacaa aaagtgaaaa atacagtgtt tacttgaaat tttaactttg taactgcaag
     2281 aattccagtt cagccgggcg aggattagta ttatttttaa ctctccgtaa gattttcagt
     2341 accaccaaat tgttttggat tttttttctt tcctcttcac ataccagggt tattaaaagt
     2401 gtgctttctt tttacattat attacagtta caaggtaaaa ttcctcaact gctatttatt
     2461 tattccagcc cagtactata aagaacgttt caccataatg accctccaga gctgggaaac
     2521 ctaccacaag atctaaagtt ctggctgtcc attaacctcc aactatggtc tttatttctt
     2581 gtggtaatat gatgtgcctt tccttgccta aatcccttcc tggtgtgtat caacattatt
     2641 taatgtcttc taattcagtc atttttttat aagtatgtct ataaacattg aactttaaaa
     2701 aacttattta tttattccac tactgtagca attgacagat taaaaaaatg taacttcata
     2761 atttcttacc ataacctcaa tgtctttttt aaaaaataaa attaaaaatg aaaagagaaa
//

LOCUS       NM_020179                953 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens FN5 protein (FN5), mRNA.
ACCESSION   NM_020179
VERSION     NM_020179.1  GI:9910225
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Kehrer-Sawatzki,H., Moschgath,E., Maier,C., Legius,E., Elgar,G. and
            Krone,W.
  TITLE     Characterization of the Fugu rubripes NLK and FN5 genes flanking
            the NF1 (Neurofibromatosis type 1) gene in the 5' direction and
            mapping of the human counterparts
  JOURNAL   Gene 251 (1), 63-71 (2000)
   PUBMED   10863097
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF197137.1.
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3-q23.3"
     gene            1..953
                     /gene="FN5"
                     /db_xref="GeneID:56935"
     CDS             231..410
                     /gene="FN5"
                     /note="go_component: cellular_component unknown [goid
                     0008372] [evidence ND];
                     go_function: molecular_function unknown [goid 0005554]
                     [evidence ND] [pmid 10863097];
                     go_process: biological_process unknown [goid 0000004]
                     [evidence ND]"
                     /codon_start=1
                     /product="FN5 protein"
                     /protein_id="NP_064564.1"
                     /db_xref="GI:9910226"
                     /db_xref="GeneID:56935"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPTITE"
ORIGIN      
        1 agcggcgcaa gcggcggcgg ccactgccac gtattcccgg cagtggtggc gggggcggcg
       61 gcggcgcccg cgggcaggaa taactcaagt cacctgtact ggaaatcagt ttgctgaaat
      121 taatcaacga ttcttgaagt tgaagaaaag gaggttccag ccttggcaag aggagtgtgg
      181 cccttcctgg aatccctctg gacacaccct cctagcatcc tctaggaaag atgcggcagc
      241 tcaaagggaa gcccaagaag gagacctcca aggacaagaa ggagcggaag caagccatgc
      301 aggaggcccg gcagcagatc actacagtgg tgctgcccac gctggccgtg gtcgtgctct
      361 tgatcgtggt gtttgtgtac gtggccacgc gccccaccat caccgagtga gccccgcagc
      421 cggctgcgga ccccatcggc agggagagga aggcgcggga gggggacgca aacaaaaaaa
      481 tggctttcat attcagagat gttcatgttg ctgagctgta agcaggagca ccctgtcttc
      541 tctggtcttt gacttgatta aagtatctcc gctttcttgg gagggaatag gggatgtttt
      601 atcagtgaat gtgccataca ccttatggtc cacttcatgt gcctttcaga cttcaaagcg
      661 cgcgcgcatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgct tctttttctc
      721 tcctaaaaat cgataagtag ctccacctga agagggatgg aacctctggg tcaggaaaca
      781 gctggaatcc acactcacct cattcccatt gtttggatca tgcttctttc caacacgtgt
      841 tcacaatctc caaagggact gtatttcttc tctgtgctta atgtgatttg aaatatgttg
      901 aatcaaagtg aaatatttat tttttgaata aaggagataa tagccttaaa aaa
//

LOCUS       NM_020731               2480 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens aryl-hydrocarbon receptor repressor (AHRR), mRNA.
ACCESSION   NM_020731
VERSION     NM_020731.2  GI:21071033
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Yamamoto,J., Ihara,K., Nakayama,H., Hikino,S., Satoh,K., Kubo,N.,
            Iida,T., Fujii,Y. and Hara,T.
  TITLE     Characteristic expression of aryl hydrocarbon receptor repressor
            gene in human tissues: organ-specific distribution and variable
            induction patterns in mononuclear cells
  JOURNAL   Life Sci. 74 (8), 1039-1049 (2004)
   PUBMED   14672759
  REMARK    GeneRIF: there existed characteristic differences in the basal
            levels of aryl hydrocarbon receptor repressor and cytochrome P450
            1A1 expression in mononuclear cells, as well as in their
            inducibility among MNCs from various types of human bloods
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Cauchi,S., Stucker,I., Cenee,S., Kremers,P., Beaune,P. and
            Massaad-Massade,L.
  TITLE     Structure and polymorphisms of human aryl hydrocarbon receptor
            repressor (AhRR) gene in a French population: relationship with
            CYP1A1 inducibility and lung cancer
  JOURNAL   Pharmacogenetics 13 (6), 339-347 (2003)
   PUBMED   12777964
  REMARK    GeneRIF: None of the polymorphisms were found to play a key role in
            CYP1A1 inducibility or in the susceptibility to develop lung cancer
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Fujita,H., Kosaki,R., Yoshihashi,H., Ogata,T., Tomita,M.,
            Hasegawa,T., Takahashi,T., Matsuo,N. and Kosaki,K.
  TITLE     Characterization of the aryl hydrocarbon receptor repressor gene
            and association of its Pro185Ala polymorphism with micropenis
  JOURNAL   Teratology 65 (1), 10-18 (2002)
   PUBMED   11835227
  REMARK    GeneRIF: Pro185Ala polymorphism is weakly associated with
            micropenis.
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Baba,T., Mimura,J., Gradin,K., Kuroiwa,A., Watanabe,T., Matsuda,Y.,
            Inazawa,J., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Structure and expression of the Ah receptor repressor gene
  JOURNAL   J. Biol. Chem. 276 (35), 33101-33110 (2001)
   PUBMED   11423533
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Watanabe,T., Imoto,I., Kosugi,Y., Fukuda,Y., Mimura,J., Fujii,Y.,
            Isaka,K., Takayama,M., Sato,A. and Inazawa,J.
  TITLE     Human arylhydrocarbon receptor repressor (AHRR) gene: genomic
            structure and analysis of polymorphism in endometriosis
  JOURNAL   J. Hum. Genet. 46 (6), 342-346 (2001)
   PUBMED   11393538
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Brown,S., Wiebel,F.J., Gelboin,H.V. and Minna,J.D.
  TITLE     Assignment of a locus required for flavoprotein-linked
            monooxygenase expression to human chromosome 2
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 73 (12), 4628-4632 (1976)
   PUBMED   1070014
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF293629.1 and BM682431.1.
            On May 22, 2002 this sequence version replaced gi:17402862.
            
            Summary: Dioxin is a teratogen that exerts its effects through the
            arylhydrocarbon receptor in conjunction with the receptor's binding
            partner, arylhydrocarbon receptor nuclear translocator. The protein
            encoded by this gene represses signal transduction by the
            arylhydrocarbon receptor by competing with the arylhydrocarbon
            receptor nuclear translocator for binding to the arylhydrocarbon
            receptor. Expression of the repressor is stimulated by the
            receptor/translocator heterodimer, thereby regulating receptor
            function through a negative feedback mechanism. In addition, the
            encoded protein can bind to nuclear factor kappa-B.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.3"
     gene            1..2480
                     /gene="AHRR"
                     /note="synonyms: AHH, AHHR, KIAA1234"
                     /db_xref="GeneID:57491"
                     /db_xref="MIM:606517"
     CDS             57..2204
                     /gene="AHRR"
                     /note="dioxin receptor repressor; aryl hydrocarbon
                     hydroxylase regulator; aryl hydrocarbon receptor
                     regulator;
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IEA];
                     go_process: signal transduction [goid 0007165] [evidence
                     IEA]"
                     /codon_start=1
                     /product="arylhydrocarbon receptor repressor"
                     /protein_id="NP_065782.1"
                     /db_xref="GI:17402863"
                     /db_xref="GeneID:57491"
                     /db_xref="MIM:606517"
                     /translation="MIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAEL
                     DHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSC
                     PLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIH
                     VDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLT
                     RCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGA
                     MLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELH
                     GKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDRE
                     EEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRG
                     SCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQH
                     QLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGC
                     VPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSR
                     ELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQ
                     WATHSQGMVPGMLPKSALATLVPPQASGCTFLP"
     polyA_signal    2459..2464
                     /gene="AHRR"
     polyA_site      2480
                     /gene="AHRR"
                     /evidence=experimental
ORIGIN      
        1 ggcacgtgga ctccctttaa tccagtgact gtcaggtcga tcatatgccg aggacgatga
       61 tcccgccggg ggagtgcacg tacgcgggcc ggaagcggag gaggcccctg cagaaacaga
      121 ggcccgccgt gggggcagag aagtccaacc cctccaagcg acaccgggac cgcctcaacg
      181 ccgagttgga ccacctggcc agcctgctgc cgttcccgcc tgacatcatc tccaagctgg
      241 acaagctttc tgtcctgcgc ctcagtgtca gttacctccg ggtgaagagc ttcttccaag
      301 tcgtgcagga gcagagctca cggcagcctg cggccggcgc cccctcgccc ggagacagct
      361 gtcctcttgc agggtctgcc gtgctggagg gaaggctgct gttggagtct cttaatggct
      421 ttgctctggt cgtgagtgca gaagggacga tattttatgc atcagcaacg atcgtggact
      481 atctgggctt ccatcagacg gatgtaatgc accagaacat ttatgactac atccacgtgg
      541 acgaccgcca ggacttctgc cggcagctcc actgggccat ggaccctccc caggtggtgt
      601 ttgggcagcc cccgcccttg gagacaggag atgatgctat cctggggagg ctgctcaggg
      661 cccaggagtg gggcacaggc acgcccaccg agtactcggc cttcctgacc cgctgcttca
      721 tctgccgtgt gcgctgcctg ctggacagca cctcgggctt cctggcccgg gggtcacagg
      781 cttggcagct gcggctctgc tgtcccgagc cactcatgac gatgcagttt caaggaaaac
      841 taaaattcct gtttggacag aagaagaagg cgccgtcagg agccatgctc ccgccgcggc
      901 tgtcgctgtt ctgcattgcg gcacccgttc tcctcccctc cgcagcggag atgaaaatga
      961 ggagcgcgct cctgagggca aaacccagag cagacaccgc agccaccgcg gatgcaaaag
     1021 taaaagccac caccagtctg tgcgaatcgg aactgcatgg aaaacccaat tactcagcag
     1081 gaaggagcag cagagagagc ggcgttttgg tgctcaggga acagactgac gctggccgat
     1141 gggcacaggt tcccgccagg gccccatgcc tgtgcctccg gggtggccct gaccttgtcc
     1201 ttgaccccaa ggggggctca ggggacaggg aggaggagca gcacaggatg ctgagcaggg
     1261 cctctggagt gacagggcgg agggagactc caggacccac aaagcccctg ccctggacag
     1321 cgggaaagca cagtgaggat ggtgccaggc cgaggctgca gcccagcaag aatgacccgc
     1381 cctccctgcg ccccatgccc cgcggctcct gcctgccctg cccgtgtgtc cagggcactt
     1441 tcaggaactc gcccatctct cacccgccga gcccgtcccc cagtgcctac tccagccgga
     1501 ccagcagacc catgcgggat gtcggtgagg accaggtgca ccctcccctc tgccactttc
     1561 cccagaggag cctgcagcac cagctccctc agcctggagc tcagcgtttt gccacgaggg
     1621 gctatcccat ggaggacatg aagctgcaag gtgtaccgat gcctccgggg gacctgtgtg
     1681 gtccgacgct gctgctagat gtgtccatca agatggagaa ggactctggg tgtgagggtg
     1741 ctgcagacgg ctgtgtgccc agccaggtgt ggctgggggc cagtgacagg agccacccag
     1801 ccaccttccc taccaggatg cacctgaaaa cagagccaga ctctcggcaa caggtgtaca
     1861 tctcgcacct ggggcacggc gtgcgggggg ctcagcccca tgggagggcc actgctgggc
     1921 gcagcaggga gctgacccct ttccaccctg cacactgtgc ctgcctggag cccacagacg
     1981 gccttcccca gtcggagcct ccccaccagc tctgtgcacg gggccgaggt gaacagtcct
     2041 gcacctgcag agctgctgag gccgcccctg tggtcaagcg ggagcccttg gactcacccc
     2101 agtgggctac tcacagccag ggaatggtgc ccgggatgtt gcccaaaagt gccttggcca
     2161 cgctggtccc gccccaagct tcggggtgca cattcctgcc atagcgcagt gaccaccatc
     2221 caagctcaga tctgtctgtc tacgctcaga tgcgtcggtg gctgggctgc cctgcgcctg
     2281 gtcagtccgg agcccgtcct aagacacact ctttgcagag ctgtgcatgc gcagtctgct
     2341 agtgtgtgtg tgcagcatac gcaggagcct atcctgaatt ttgtaaaata tcccaacagt
     2401 tcttaaatga aaactggcct taagtctatt caagcatgac agcatttctc tttgaggaat
     2461 taaaatcttt aggaaagtga
//

LOCUS       NM_020841               7259 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens oxysterol binding protein-like 8 (OSBPL8), transcript
            variant 1, mRNA.
ACCESSION   NM_020841
VERSION     NM_020841.4  GI:51243030
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7259)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   2  (bases 1 to 7259)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J. Lipid Res. 42 (8), 1203-1213 (2001)
   PUBMED   11483621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF392452.1 and AL832876.1.
            On Aug 16, 2004 this sequence version replaced gi:22035617.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Like most members, the encoded protein contains an N-terminal
            pleckstrin homology domain and a highly conserved C-terminal
            OSBP-like sterol-binding domain. Two transcript variants encoding
            different isoforms have been found for this gene.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..7259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14"
     gene            1..7259
                     /gene="OSBPL8"
                     /note="synonyms: ORP8, OSBP10"
                     /db_xref="GeneID:114882"
                     /db_xref="MIM:606736"
     CDS             481..3150
                     /gene="OSBPL8"
                     /note="isoform a is encoded by transcript variant 1;
                     oxysterol-binding protein-related protein 8; OSBP-related
                     protein 8;
                     go_process: lipid transport [goid 0006869] [evidence IEA];
                     go_process: steroid metabolism [goid 0008202] [evidence
                     IEA]"
                     /codon_start=1
                     /product="oxysterol-binding protein-like protein 8 isoform
                     a"
                     /protein_id="NP_065892.1"
                     /db_xref="GI:18079218"
                     /db_xref="GeneID:114882"
                     /db_xref="MIM:606736"
                     /translation="MEGGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMS
                     QRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLY
                     NGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGT
                     LKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQ
                     SIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIR
                     EGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKE
                     NDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGE
                     ASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLS
                     EAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYI
                     AEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDY
                     VMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGK
                     LKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFE
                     SEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGE
                     WHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYS
                     SPEPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLV
                     SSTPATDYFLQQKDYFIIFLLILLQVIINFMFK"
     polyA_signal    7219..7224
                     /gene="OSBPL8"
     polyA_site      7237
                     /gene="OSBPL8"
                     /evidence=experimental
     polyA_site      7242
                     /gene="OSBPL8"
ORIGIN      
        1 cactagaatg tgaaggatct tcgcggttct gggtgcccag aaaggcggcg acgcggcgga
       61 tgacaacatt aggccgcgac gcgctcctgg ccaggcggcg gctgtagtgt tagctttgga
      121 cgccgcagta gccgctgccg gtagcaagcc gactgaggga aggtgggggt ccgcccgggc
      181 tggtggacct cggggccgaa agttcccgcc ccgctcgggg gctgagccgg cagtgcctcc
      241 gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg
      301 gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc
      361 gacctcggag gaaccggctc cttgcgtccc gcctccctgg gagctccgca cgggatttgc
      421 agatttacag aatggctgca cattaatgga aagagaagca taaacctatc ttctttcatt
      481 atggagggag gtttggcaga tggagaacct gatcgaactt cgcttcttgg tgatagcaaa
      541 gatgtccttg ggccatcaac tgttgtagca aacagtgacg aatctcagct tctgacacca
      601 ggaaagatga gtcagcgcca aggaaaagaa gcttatccaa cgccaaccaa agatttgcat
      661 cagccatctc ttagtccagc aagtcctcat agccagggtt ttgaaagagg gaaggaagat
      721 atttctcaaa ataaagatga atcttcactt tctatgtcaa agagcaagtc tgaatctaaa
      781 ctttataatg gctcagagaa ggacagttca acttcaagca aactcacaaa aaaagaatct
      841 cttaaggtac aaaagaaaaa ttaccgagaa gaaaagaaaa gagccacaaa ggagctgctc
      901 agtacaatca cagatccttc tgttattgtt atggctgatt ggttaaagat tcgtggtact
      961 ctaaagagct ggaccaagtt atggtgtgtg ttgaaacctg gggtgctact gatctataaa
     1021 acccaaaaaa atggtcagtg ggtaggaaca gttcttctga atgcctgtga aatcattgaa
     1081 cgtccatcaa aaaaggatgg cttttgtttc aaacttttcc atcctttgga gcaatctatt
     1141 tgggcagtga agggtccaaa aggtgaagcg gttggatcca ttactcaacc cttacctagc
     1201 agttatttga tcatccgagc tacttcagag tcagatggaa ggtgctggat ggatgctttg
     1261 gagttggctt tgaaatgttc tagtcttctt aaacgtacaa tgatcagaga aggaaaggaa
     1321 catgacctga gcgtttcatc agatagcaca catgtgactt tctatggctt actacgtgct
     1381 aacaatctcc acagtggtga taacttccag ttaaatgata gtgaaattga acgacaacat
     1441 tttaaggacc aagatatgta ttctgataaa tctgataaag aaaatgatca agaacatgat
     1501 gagtctgata atgaggtgat ggggaaaagt gaagaaagtg acacagatac atcagaaaga
     1561 caagatgact catatatcga acctgagcct gttgagcctt taaaggagac tacctacact
     1621 gaacagagcc atgaagaact tggagaggca ggtgaggctt ctcaaacaga aactgtatct
     1681 gaagaaaaca aaagccttat ctggacacta ttgaaacaag tccgtcctgg catggaccta
     1741 tccaaggtgg ttctgcctac atttattttg gaaccccgtt ctttcctgga taaactttca
     1801 gattactact atcatgcaga tttcctatct gaggcagctc ttgaagaaaa tccttatttc
     1861 cgtttgaaga aagtagtgaa atggtatttg tcaggattct ataaaaagcc aaagggactg
     1921 aagaaacctt ataatcctat acttggcgag actttccgtt gtttatggat tcatcccaga
     1981 acaaacagca aaacttttta tattgctgaa caggtgtccc atcatccacc aatatctgcc
     2041 ttttatgtta gtaatcgaaa agatggattt tgccttagcg gtagtatcct ggctaagtct
     2101 aagttttatg gaaactcatt atctgcaata ttagagggag aagcacggtt aactttcttg
     2161 aatagaggtg aagattatgt aatgacaatg ccatacgctc attgtaaagg aattctttat
     2221 ggtacaatga cactggagct tggtggaaca gtcaatatta catgtcaaaa aactggatac
     2281 agtgcaatac ttgaatttaa actaaagcca ttcctaggga gtagtgactg tgttaatcaa
     2341 atatcaggga aacttaaact gggaaaagaa gtcctagcta ctttggaagg tcattgggat
     2401 agtgaagttt ttattactga taaaaagact gataattcag aggttttctg gaatccaaca
     2461 cctgacatta agcaatggag attaataagg cacactgtaa aatttgaaga acagggagat
     2521 tttgaatcag agaaactctg gcaacgggta actcgagcca taaatgccaa agaccaaact
     2581 gaagctaccc aagagaagta tgttttggaa gaagctcaaa gacaagctgc cagggatcgg
     2641 aaaacaaaaa atgaagagtg gtcttgcaaa ttatttgaac ttgatccact cacaggagaa
     2701 tggcattaca agtttgcaga tacccgacca tgggacccac ttaatgatat gatacagttt
     2761 gaaaaagatg gtgttattca gaccaaagtg aaacatcgta ctccaatggt tagcgtcccc
     2821 aaaatgaaac ataagccaac caggcaacag aagaaagtag caaaaggcta ttcctcccca
     2881 gaacctgaca ttcaagactc ctctggaagt gaagctcaat cagtaaaacc aagtacaaga
     2941 agaaagaaag gaatagaact gggagacatt cagagttcca tcgaatctat aaaacaaaca
     3001 caggaagaaa ttaaaagaaa tattatggct cttcgaaatc atttagtttc aagcacaccg
     3061 gccacggatt attttctgca acaaaaagac tacttcatca ttttcctcct gattttgctt
     3121 caagtcataa taaacttcat gttcaagtag aagttctcta ccattgaatc agtgaactag
     3181 aaagatctga tttggcctgg gaccagtgtt caagttggtt tggtctttat taaaaatcac
     3241 aatattccga aaacaaaaaa acctaggaga taaatgtaga ggtattgact tttcgtatct
     3301 tttatcttca cactgaaaca agagctatcc tatttgatta ttaaagtgag ctatgtgtta
     3361 agtgccagga catttctagc ttttgtgaga atgtgtctac atatgagtat aataaaccca
     3421 catgtataca caattgtctc ttatgtactc ctacctgaca gtagtctttg tattctatag
     3481 tatgttctga gatataatgt taacattgtt cataacaaaa aatgctatca atcttataaa
     3541 tatatgtaat ctattttctt cataaaacag gcacaaaagt tttatcagta aggaattaca
     3601 gattgagaaa tgatggaata atagacataa ttaattcaat acactactgt taaaatcatt
     3661 tgcaaagcac tcagctcaat tatcttctta gaaagaaaga aaaagtatga atggtcaaaa
     3721 tgaatacatc gagagagata aatggcaaat tgctttttta aaagtttaca taagtttttt
     3781 ttaaccccta gaatttaata tttgtagatg caggtaaata tatatactta cgtgtatatc
     3841 agtataaaaa cactggtgtg caattaattg gattgattat aataccacct taagcacttg
     3901 ctgaaaaaag tgtggtcaaa attgattgct gtccttttgt cttatttttg tttttcttaa
     3961 gtcagctggt tcataacata ggccaaattc tagagatgtt tatagagcat ttgaagtgct
     4021 gataatttat gttttttcat tatgaaaact tattttagct ttagactcca gtgtgttcag
     4081 tgaataagta gaatataaaa aaatataacc agtattttac ttcaaaagcc aaaaagaggc
     4141 aataagaaaa gacactttgt ggtggccttt atgtgtgcat taaaattggt ttctgtaaaa
     4201 cgtgtaataa gttgagtatc tacgaagagt atcaagttct gaagtttaat ttttttatta
     4261 tcctcctctc ttcttagtaa cttctttctg tggcaaaacc acaattcttt aagattccta
     4321 ttgttcaggc taaggcaaat ttttttgttt gtttcttcag tttaatattt tgattttgtg
     4381 tttttacgta aatatttata ttccttgaaa gcaatttttg ccaaggtagt tcagtttagg
     4441 aatatgttgt tctaaaatat gtcttagaat cctgaaagca tagattttga aatgtttttt
     4501 taatgaaaat gaaggtcaga gagaataatt gccctgacca catttgcctt tcagtaggag
     4561 gaggctgtga aatagtaaaa ttataatcgt ttatgccatg ataaatacaa gattggtaaa
     4621 taaatacatt gattggtaaa ttatgagaat caaaatgata aaaagagcct gcttttttcc
     4681 ctaaccaata tagctatctt aagtatcctt aggtttctgt gaagaaccat ttcccatgtt
     4741 ttcttggcaa aataatgctg tattccatat gtacatgtga aatgatgttt taaattgata
     4801 aaagcttaaa taagatctac ctatacccag tattttcatg atattagaac aaatgggttt
     4861 ttggttatat tttatatttg tcaatataat ttttgtattc acattctgtt acactctgcc
     4921 tattcattga tatatgatat tctgtaaata ttgtacaatt tgatcttttt tatggtttaa
     4981 attagttaat tacatacaaa ttgattggct tatcacaaaa atcatttcat cagtaaacct
     5041 tgttaacatt ttgtactggt gacccacctc ttaggacttt ggtcttatcc acgtgtatgt
     5101 tgttttcatt tggtccaaat aatattttat ttgtatgggt atcttctaag actaaatagg
     5161 tagttgtgtt ctttattttt aaaatttctt tttagagcaa atgttatggg ttcttaccca
     5221 aagagtcaaa aactatttct taagaaagag cagagttatt catgactgtt ctttatacac
     5281 taaaagcatg catctaatct aatagtcctc ttattatgct tttagttgta tgagtctctt
     5341 tctatgaact gaacacaaaa ctcaggaatt ggtggcttaa ttttagatca gtgcttgtac
     5401 taggcttagt tatatgaatc tttataacac ataattacta actttgtagc catatatgta
     5461 attgactttg aatgttattt acctgaaatt aatcttcctt cacacatgga ccgtaaacgg
     5521 ttcccagttg tctgagagcc tcatgagggt ttctaggatt tatgacctta tgaccagttt
     5581 ttttcattta ccaagatttt attttcctac atgaaaattt aattgagtaa taattattca
     5641 catgtgcatt ttctttttag ctgttaaatg tactatgcca tcatccacca tttagtaaaa
     5701 tgtagctggc ccaggacatg taaaaaaaaa aaaaaaacaa caacaataaa tagggcatgt
     5761 gaaatgttaa gttacagcaa tagatatttt atttgtattt catgttagta cttttttgtt
     5821 ttatatcact tataaaggta cagtgtactc tttgtcacag ctcagttggt aaccgcattc
     5881 cattgaaaag ttggccttgt aaaatacaac tctcatttaa tattcatgct tttgtgcctt
     5941 taagaaaata ttttttgtca ttttttgtgt tacagaacta taatgtgatt caaggtgttt
     6001 ataggcttgt cataaaaggg tcatttctgt gtgttacttt ctttttatat agctatagta
     6061 tatttaaaca ataatactat cttttatagg ggtttgtcta tttacctatt ctttactcag
     6121 acattgatgt agacttgtca gattattctg agtattgtta acagtgcctt ttcgatggaa
     6181 tcacactttt tggctgtcac cttgtgccat atacacacaa aattttgtgg aaggcagttt
     6241 taactttctg aagaatatct gtcaaaattt aagaaaacaa atgtataaaa ttccattttt
     6301 tccagtgttt agcatttcta gtaagcagtg aggttgtttg acatacagtg atgatggcat
     6361 tattgataag ccatacatga gactgcagat tatattgaat catattaaat gtacagaaat
     6421 aaaatattag atttatatca aattttccaa tttgaaccag tggggaaaat cccacagaaa
     6481 tcagtaagtt tacatttcaa tttctatctt atttgactaa gtggaaagag attctttaaa
     6541 atgtataacc tgccattatg taatttggtt tcattttatt ctacctgttg tgtgagttta
     6601 gtatatttaa tttacttttt gttactcttt acatactgtt tatttttgtt agtttttaat
     6661 tgaagatgga ctgttgaaat tgtataggac cagtgtctta ttaatatgat taatatattt
     6721 agaagagcca cgtgaaaccc atgacaaaat gaatgtgaat attctttcta aaaatttaga
     6781 aaatgttatc tttttgcatt tattatgtaa aactgtttta cagtatcaaa atttttcact
     6841 taaagaaaaa aaatgccatg aaacatttga actgatgagc cacagaactt cagttgaaat
     6901 ttttttcact ttttagcatg ctaaatatac atctgagttt aaatgttctg tttaatggcc
     6961 attcataaat tcaagcacta ccactggtca gttttgtgtg atagaataaa aatatgttac
     7021 ctgcagtgta agtacagcac actgtcaaat tcttttcctt aaggtgcaca gtaaatgtac
     7081 agatagttat aggccactgt tttgtaatgt agtacatttc taatctatta ttcctaacct
     7141 attataactg tttgcagaaa gaaaagaatt tttctaataa tctgtaaaat tatgctaact
     7201 tctacaagta ggcttctaaa taaaattttt aaaaagagca aaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_021198               2655 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II,
            polypeptide A) small phosphatase 1 (CTDSP1), mRNA.
ACCESSION   NM_021198
VERSION     NM_021198.1  GI:10864008
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2655)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J. Biol. Chem. 278 (28), 26078-26085 (2003)
   PUBMED   12721286
  REMARK    GeneRIF: SCP1 may play a role in the regulation of gene expression,
            possibly by controlling the transition from initiation/capping to
            processive transcript elongation
REFERENCE   2  (bases 1 to 2655)
  AUTHORS   Ma,X., Wright,J., Dou,S., Olsen,P., Teeter,L., Adams,G. and
            Graviss,E.
  TITLE     Ethnic divergence and linkage disequilibrium of novel SNPs in the
            human NLI-IF gene: evidence of human origin and lack of association
            with tuberculosis susceptibility
  JOURNAL   J. Hum. Genet. 47 (3), 140-145 (2002)
   PUBMED   11950066
  REMARK    GeneRIF: Polymorphisms vary significantly between races; Not
            associated with TB susceptibility in Caucasians.
REFERENCE   3  (bases 1 to 2655)
  AUTHORS   Marquet,S., Lepage,P., Hudson,T.J., Musser,J.M. and Schurr,E.
  TITLE     Complete nucleotide sequence and genomic structure of the human
            NRAMP1 gene region on chromosome region 2q35
  JOURNAL   Mamm. Genome 11 (9), 755-762 (2000)
   PUBMED   10967134
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF229162.1.
FEATURES             Location/Qualifiers
     source          1..2655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2655
                     /gene="CTDSP1"
                     /note="synonyms: SCP1, NLIIF"
                     /db_xref="GeneID:58190"
                     /db_xref="MIM:605323"
     CDS             337..1122
                     /gene="CTDSP1"
                     /note="nuclear LIM interactor-interacting factor; small
                     CTD phosphatase 1;
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     10967134];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: phosphoprotein phosphatase activity [goid
                     0004721] [evidence IEA];
                     go_process: biological_process unknown [goid 0000004]
                     [evidence ND]"
                     /codon_start=1
                     /product="CTD (carboxy-terminal domain, RNA polymerase II,
                     polypeptide A) small phosphatase 1"
                     /protein_id="NP_067021.1"
                     /db_xref="GI:10864009"
                     /db_xref="GeneID:58190"
                     /db_xref="MIM:605323"
                     /translation="MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFC
                     CVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLV
                     HSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYAD
                     PVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDN
                     AVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS"
ORIGIN      
        1 cgcctagccg cgccggtccc agaagtggcg aaagccgcag ccgagtccag gtcacgccga
       61 agccgttgcc cttttaaggg ggagccttga aacggcgcct gggttccatg tttgcatccg
      121 cctcgcggga aggaaactcc atgttgtaac aaagtttcct ccgcgccccc tccctccccc
      181 tcccccctag aacctggctc ccctcccctc cggagctcgc ggggatccct ccctcccacc
      241 cctcccctcc cccccgcgcc ccgattccgg ccccagccgg gggggaggcc gggcgcccgg
      301 gccagagtcc ggccggagcg gagcgcgccc ggccccatgg acagctcggc cgtcattact
      361 cagatcagca aggaggaggc tcggggcccg ctgcggggca aaggtgacca gaagtcagca
      421 gcttcccaga agccccgaag ccggggcatc ctccactcac tcttctgctg tgtctgccgg
      481 gatgatgggg aggccctgcc tgctcacagc ggggcgcccc tgcttgtgga ggagaatgga
      541 gccatcccta agcagacccc agtccaatac ctgctccctg aggccaaggc ccaggactca
      601 gacaagatct gcgtggtcat cgacctggac gagaccctgg tgcacagctc cttcaagcca
      661 gtgaacaacg cggacttcat catccctgtg gagattgatg gggtggtcca ccaggtctac
      721 gtgttgaagc gtcctcacgt ggatgagttc ctgcagcgaa tgggcgagct ctttgaatgt
      781 gtgctgttca ctgctagcct cgccaagtac gcagacccag tagctgacct gctggacaaa
      841 tggggggcct tccgggcccg gctgtttcga gagtcctgcg tcttccaccg ggggaactac
      901 gtgaaggacc tgagccggtt gggtcgagac ctgcggcggg tgctcatcct ggacaattca
      961 cctgcctcct atgtcttcca tccagacaat gctgtaccgg tggcctcgtg gtttgacaac
     1021 atgagtgaca cagagctcca cgacctcctc cccttcttcg agcaactcag ccgtgtggac
     1081 gacgtgtact cagtgctcag gcagccacgg ccagggagct agtgagggtg atggggccag
     1141 gacctgcccc tgaccaatga tacccacacc tcctcccagg aagactgccc aggcctttgt
     1201 taggaaaacc catgggccgc cgccacactc agtgccatgg ggaagcgggc gtctccccca
     1261 ccagccccac caggcggtgt aggggcagca ggctgcactg aggaccgtga gctccaggcc
     1321 ccgtgtcagt gccttcaaac ctcctcccct attctcaggg gacctggggg gccctgcctg
     1381 ctgctccctt tttctgtctc tgtccatgct gccatgtttc tctgctgcca aattgggccc
     1441 cttggcccct tccggttctg cttcctgggg gcagggttcc tgccttggac ccccagtctg
     1501 ggaacggtgg acatcaagtg ccttgcatag agccccctct tccccgccca gctttcccag
     1561 gggcacagct ctaggctggg aggggagaac cagcccctcc ccctgcccca cctcctccct
     1621 tgggactgag agggccccta ccaacctttg cctctgcctt ggagggaggg gaggtctgtt
     1681 accactgggg aaggcagcag gagtctgtcc ttcaggcccc acagtgcagc ttctccaggg
     1741 ccgacagctg agggctgctc cctgcatcat ccaagcaatg acctcagact tctgccttaa
     1801 ccagccccgg ggcttggctc ccccagctct gagcgtgggg gcataggcag gacccccctt
     1861 gtggtgccat ataaatatgt acatgtgtat atagattttt aggggaagga gagagggaag
     1921 ggtcagggta gagacacccc tcccttgccc ctttcctggg cccagaagtt ggggggaggg
     1981 agggaaagga tttttacatt ttttaaactg ctattttctg aatggaacaa gctgggccaa
     2041 ggggcccagg ccctgtcctc tgtccctcac acccctttgc tccgttcatt cattcaaaaa
     2101 aacatttctt gagcaccttc tgtgcccagc atatgctagg cccaccagct aagtgtgtgt
     2161 ggggggtctc tacgccagct catcagtgcc tccttgccca tccttcaccg gtgcctttgg
     2221 gggatctgta ggaggtggga ccttctgtgg ggtttgggga tctccaggaa gcccgaccaa
     2281 gctgtcccct tcccctgtgc caacccatct cctacagccc cctgcctgat cccctgctgg
     2341 ctgggggcag ctcccaggat atcctgcctt ccaactgttt ctgaagcccc tcctcctaac
     2401 atggcgattc cggaggtcaa ggccttgggc tctccccagg gtctaacggt taaggggacc
     2461 cacataccag tgccaagggg gatgtcaagt ggtgatgtcg ttgtgctccc ctcccccaga
     2521 gcgggtgggc ggggggtgaa tatggttggc ctgcatcagg tggccttccc atttaagtgc
     2581 cttctctgtg actgagagcc ctagtgtgat gagaactaaa gagaaagcca gacccctaaa
     2641 aaaaaaaaaa aaaaa
//

LOCUS       NM_021961               4357 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens TEA domain family member 1 (SV40 transcriptional
            enhancer factor) (TEAD1), mRNA.
ACCESSION   NM_021961
VERSION     NM_021961.2  GI:38570152
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4357)
  AUTHORS   Fossdal,R., Jonasson,F., Kristjansdottir,G.T., Kong,A.,
            Stefansson,H., Gosh,S., Gulcher,J.R. and Stefansson,K.
  TITLE     A novel TEAD1 mutation is the causative allele in Sveinsson's
            chorioretinal atrophy (helicoid peripapillary chorioretinal
            degeneration)
  JOURNAL   Hum. Mol. Genet. 13 (9), 975-981 (2004)
   PUBMED   15016762
  REMARK    GeneRIF: A missense mutation (Y421H) in TEAD1 is tightly linked to
            Sveinsson's chorioretinal atrophy (SCRA), an autosomal dominant eye
            disease characterized by symmetrical lesions radiating from the
            optic disc involving the retina and the choroid.
REFERENCE   2  (bases 1 to 4357)
  AUTHORS   Karasseva,N., Tsika,G., Ji,J., Zhang,A., Mao,X. and Tsika,R.
  TITLE     Transcription enhancer factor 1 binds multiple muscle MEF2 and
            A/T-rich elements during fast-to-slow skeletal muscle fiber type
            transitions
  JOURNAL   Mol. Cell. Biol. 23 (15), 5143-5164 (2003)
   PUBMED   12861002
  REMARK    GeneRIF: Transcription enhancer factor 1 binds multiple muscle MEF2
            and A/T-rich elements during fast-to-slow skeletal muscle fiber
            type transitions
REFERENCE   3  (bases 1 to 4357)
  AUTHORS   Maeda,T., Chapman,D.L. and Stewart,A.F.
  TITLE     Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2
            transcription factors that promotes skeletal muscle differentiation
  JOURNAL   J. Biol. Chem. 277 (50), 48889-48898 (2002)
   PUBMED   12376544
  REMARK    GeneRIF: TEAD1 (TEF-1) interacts with a muscle-specific cofactor to
            promote skeletal muscle gene expression.
REFERENCE   4  (bases 1 to 4357)
  AUTHORS   Carlini,L.E., Getz,M.J., Strauch,A.R. and Kelm,R.J. Jr.
  TITLE     Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle
            cells. Suppression of TEF-1 mediated activation by the
            single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1
  JOURNAL   J. Biol. Chem. 277 (10), 8682-8692 (2002)
   PUBMED   11751932
  REMARK    GeneRIF: These results are consistent with two plausible models of
            cryptic MCAT enhancer regulation by Pur alpha, Pur beta, and MSY1
            involving either competitive single-stranded DNA binding or masking
            of MCAT-bound transcription enhancer factor-1.
REFERENCE   5  (bases 1 to 4357)
  AUTHORS   Jacquemin,P., Depetris,D., Mattei,M.G., Martial,J.A. and
            Davidson,I.
  TITLE     Localization of human transcription factor TEF-4 and TEF-5 (TEAD2,
            TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence
            in situ hybridization and radiation hybrid analysis
  JOURNAL   Genomics 55 (1), 127-129 (1999)
   PUBMED   9889009
REFERENCE   6  (bases 1 to 4357)
  AUTHORS   Boam,D.S., Davidson,I. and Chambon,P.
  TITLE     A TATA-less promoter containing binding sites for ubiquitous
            transcription factors mediates cell type-specific regulation of the
            gene for transcription enhancer factor-1 (TEF-1)
  JOURNAL   J. Biol. Chem. 270 (33), 19487-19494 (1995)
   PUBMED   7642633
REFERENCE   7  (bases 1 to 4357)
  AUTHORS   Shimizu,N., Smith,G. and Izumo,S.
  TITLE     Both a ubiquitous factor mTEF-1 and a distinct muscle-specific
            factor bind to the M-CAT motif of the myosin heavy chain beta gene
  JOURNAL   Nucleic Acids Res. 21 (17), 4103-4110 (1993)
   PUBMED   8396764
REFERENCE   8  (bases 1 to 4357)
  AUTHORS   Xiao,J.H., Davidson,I., Matthes,H., Garnier,J.M. and Chambon,P.
  TITLE     Cloning, expression, and transcriptional properties of the human
            enhancer factor TEF-1
  JOURNAL   Cell 65 (4), 551-568 (1991)
   PUBMED   1851669
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from M63896.1, AI199443.1 and
            AL833289.1.
            On Dec 1, 2003 this sequence version replaced gi:11386150.
FEATURES             Location/Qualifiers
     source          1..4357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4357
                     /gene="TEAD1"
                     /note="synonyms: TCF13, TEF-1"
                     /db_xref="GeneID:7003"
                     /db_xref="MIM:189967"
     CDS             498..1733
                     /gene="TEAD1"
                     /note="transcriptional enhancer factor 1; transcription
                     factor 13; SV40 transcriptional enhancer factor;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="TEA domain family member 1"
                     /protein_id="NP_068780.1"
                     /db_xref="GI:11386151"
                     /db_xref="GeneID:7003"
                     /db_xref="MIM:189967"
                     /translation="MERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKII
                     LSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDK
                     ALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPF
                     VQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDS
                     YNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFW
                     ADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRF
                     VYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVF
                     EVSNSEHGAQHHIYRLVKD"
ORIGIN      
        1 cggccgcgtc caggcacagg ccatgcagtg acgccccccc acccctccac ctttgcccgg
       61 acggcgggca gcagcccagc gcgccagccg gccccggggc aggagcggtg ctaggcaggg
      121 gtggggtggc cgggcccagg gaccgggagc cggggaggga gccgggcacc gagcagaggg
      181 cgggggaagc ggcgccgaag tttgcctcgg actcgccggg cgctgcggtg gctccctggg
      241 ccgaggactg ttgctgccgc tgccgccgcc gcttcattgc acattcaagt ggaaaatttt
      301 caggagtcag cagaaacatt gtgtccaaaa aagactgagt cgcagttacc accaaaccca
      361 ggaggagact ctccctggaa aacttccctt ccctttcggt ttattttctt gaaaaggctc
      421 caggcttcgg cttggaaaat cccaccgcca aaattgagcc cagcagctgg agcggcagtg
      481 agagccctgc cgaaaacatg gaaaggatga gtgactctgc agataagcca attgacaatg
      541 atgcagaagg ggtctggagc cccgacatcg agcaaagctt tcaggaggcc ctggctatct
      601 atccaccatg tgggaggagg aaaatcatct tatcagacga aggcaaaatg tatggtagga
      661 atgaattgat agccagatac atcaaactca ggacaggcaa gacgaggacc agaaaacagg
      721 tgtctagtca cattcaggtt cttgccagaa ggaaatctcg tgattttcat tccaagctaa
      781 aggatcagac tgcaaaggat aaggccctgc agcacatggc ggccatgtcc tcagcccaga
      841 tcgtctcggc cactgccatt cataacaagc tggggctgcc tgggattcca cgcccgacct
      901 tcccaggggc gccggggttc tggccgggaa tgattcaaac agggcagcca ggatcctcac
      961 aagacgtcaa gccttttgtg cagcaggcct accccatcca gccagcggtc acagccccca
     1021 ttccagggtt tgagcctgca tcggccccag ctccctcagt ccctgcctgg caaggtcgct
     1081 ccattggcac aaccaagctt cgcctggtgg aattttcagc ttttctcgag cagcagcgag
     1141 acccagactc gtacaacaaa cacctcttcg tgcacattgg gcatgccaac cattcttaca
     1201 gtgacccatt gcttgaatca gtggacattc gtcagattta tgacaaattt cctgaaaaga
     1261 aaggtggctt aaaggaactg tttggaaagg gccctcaaaa tgccttcttc ctcgtaaaat
     1321 tctgggctga tttaaactgc aatattcaag atgatgctgg ggctttttat ggtgtaacca
     1381 gtcagtacga gagttctgaa aatatgacag tcacctgttc caccaaagtt tgctcctttg
     1441 ggaagcaagt agtagaaaaa gtagagacgg agtatgcaag gtttgagaat ggccgatttg
     1501 tataccgaat aaaccgctcc ccaatgtgtg aatatatgat caacttcatc cacaagctca
     1561 aacacttacc agagaaatat atgatgaaca gtgttttgga aaacttcaca attttattgg
     1621 tggtaacaaa cagggataca caagaaactc tactctgcat ggcctgtgtg tttgaagttt
     1681 caaatagtga acacggagca caacatcata tttacaggct tgtaaaggac tgaacatggt
     1741 tatttatata tatagatatc tgtatataca cacacacata tgtgcacaca cacactctct
     1801 ctccattatc gaacgactga ctgtaaacct caccacacag ggtggtgccc tggccccgag
     1861 gtcaccccga cttttctaaa tcttgtttga gtgaagtcat tttttcatgt gttcatacta
     1921 tcattgtagc tgtgaagttc tggtacagtt gtaaaaagag aaattgagtt gtttctctat
     1981 gttcttcaga tgtgcagccc acaattcctc gggaaaggtg aacctgaaca acccaagtct
     2041 ctctctgcag agccctgttt ctaattgtgg tagaaaatat tgagacagag catttgccat
     2101 gggacattta cagcctttat acaaatgtat ttagttctct tttttccaac ataaaattct
     2161 tgttttaaga tacaagtaaa attaatcttt aaatataaat gtaaattagt acacaaaact
     2221 aagaatcttt agacttatct ttgtaactaa ttagggtgga agttatgaaa gaatgtaatt
     2281 cactaaatta ttttttaaat gaaacctttt tttttctttt tgaaaccaaa tgttaaacta
     2341 tagccttaag aaatgcttgg tagaagtgtc ctaatgagac aaatttgtac ttttatcctc
     2401 aaggttaaca ctaatctcct aatccattaa actcttgaac aggtattaca aaggaagaaa
     2461 acttcacccc ttatccttaa catatatagt atatttaaaa aatataaaat tgtattgtac
     2521 taatgtgatg atggattatt taatgaaaaa gaaaaaatgg ctctttttgc aataagtaga
     2581 tacatactga aaaagtctaa acttacaatg tttatagtct tgtgtgtgca gttatatttt
     2641 atatggacga ccaaattttt tattaagatg agtaaatatt tgaaccactg aattttaata
     2701 acaaaatttt aaaattggca tgaatacgga atactgcact gtgagatgca aagtatacag
     2761 aatctgtggc tgggagaaaa tttcatcaaa tagacaagta aaaggctcat cagttttagc
     2821 atctctgctc cccagaaaat tgtaagcatc ctcaccagcc tgtggataca ttctttattt
     2881 ctagtgaccc aatatgcata ttaacctgct ataactaggg ctatatgtgt aggtatgtgt
     2941 atacatatac acaaatgcac atatagagtt aacacattta gtgaacactt gtttagtgtc
     3001 actcagtttg ctaggtgctg atatgtacgt atatctcaat gtgtctgtag acttagatac
     3061 atcctcttga agcacatcca tttctttagc gtctctcagt aagttacagt acttgtttga
     3121 cttaggttta agaggcccag ctacctatct ctgacctttt caaataggct catttgggag
     3181 attcttttgc caggagagat tcaactttcc aatctaagta ttccagagca ttgcccaggc
     3241 agagttggtt tgatgtggcc agatgttttg agttatttcc cttaagtgtt tcactgggga
     3301 gagaacaggg agtgctcctc cagcttccca aagaaatatg tttttgtaag tggtaggaac
     3361 atgtgcacac aatagaacat gaaataagtt ttttaacttg taaaacatgt caagattttt
     3421 ccaccaagct agaaaataaa aaacttagtt ctaccacatc caattaactt acacaccccc
     3481 ttccctgtct caacacctgc tttgaccctg cttttctatt attacatcag tcagcatctt
     3541 gtggtcccta acatgaggat gtggctggct cgtgggaaac agcaaaacac taagcctgac
     3601 ctctcccaaa ttgggaagac cagaggagaa agtgcaaaac tgtccccatt tggaatgccc
     3661 attccttcta gaaaccagtt ggacagtgct cctctgccct tcataaacag actactgttg
     3721 ggtccctgat tccaggctgg cctgtgaagg attgccccag gtgtcccctt tcacggttgt
     3781 cacatttaca gtgacttctg ttgaacaccc ctcttaggga tgtttctttt gctcttattt
     3841 cctgcatctt tccttaaggg aagccccatc ctctcccagg accaggagtt tatgaccagg
     3901 cgagcacaaa tggctaaaag ccaagctgtc ctagaacttc agtgggagag ctgtctggtt
     3961 catattctac ccaggaatgg tacttttcag tgcagccagg agggctcttg ggatttcctt
     4021 tccaaagcac aaaaatactg ggacccaaga agaacagcta gaggacaact ctgttggcac
     4081 agagacgggg acagcccagt ctgctgacct cacagggtca gctgggcccc cctggtgctt
     4141 caccacctgc atcctcttgc tcagaatgcc tttgcagttg agttttctgg gtttctatga
     4201 ttgaccttga ggtttactcc ttgctcttac aacatttcta aggattttta aaagtttact
     4261 tcttgtcttg ttcttctaaa gctttctcca ggacagatat tttccctgtc ttaaccactg
     4321 gtccagtcat cccagtgggc ttctctttgt ctctccc
//

LOCUS       NM_021975               1760 bp    mRNA    linear   PRI 28-OCT-2004
DEFINITION  Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A,
            nuclear factor of kappa light polypeptide gene enhancer in B-cells
            3, p65 (avian) (RELA), mRNA.
ACCESSION   NM_021975
VERSION     NM_021975.2  GI:46430498
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Zamora,M., Mero, Vi and Mampel,T.
  TITLE     Recruitment of NF-kappaB into mitochondria is involved in adenine
            nucleotide translocase 1 (ANT1)-induced apoptosis
  JOURNAL   J. Biol. Chem. 279 (37), 38415-38423 (2004)
   PUBMED   15231833
  REMARK    GeneRIF: mitochondrial recruitment of NF-kappaB observed following
            ANT1 overexpression has an important role in ANT1 proapoptotic
            activity
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Jeong,S.J., Radonovich,M., Brady,J.N. and Pise-Masison,C.A.
  TITLE     HTLV-I Tax induces a novel interaction between p65/RelA and p53
            that results in inhibition of p53 transcriptional activity
  JOURNAL   Blood 104 (5), 1490-1497 (2004)
   PUBMED   15155458
  REMARK    GeneRIF: unique mechanism for p53 regulation by the p65/RelA
            subunit of NF-kappaB.
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Bohuslav,J., Chen,L.F., Kwon,H., Mu,Y. and Greene,W.C.
  TITLE     p53 induces NF-kappaB activation by an IkappaB kinase-independent
            mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
  JOURNAL   J. Biol. Chem. 279 (25), 26115-26125 (2004)
   PUBMED   15073170
  REMARK    GeneRIF: NF-kappaB activation is induced by p53 by an IkappaB
            kinase-independent mechanism involving phosphorylation of p65 by
            ribosomal S6 kinase 1
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Yeh,P.Y., Yeh,K.H., Chuang,S.E., Song,Y.C. and Cheng,A.L.
  TITLE     Suppression of MEK/ERK signaling pathway enhances cisplatin-induced
            NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB
            p65 Thr dephosphorylation
  JOURNAL   J. Biol. Chem. 279 (25), 26143-26148 (2004)
   PUBMED   15073167
  REMARK    GeneRIF: NF-kappaB p65 Thr dephosphorylation is activated by
            protein phosphatase 4
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Jang,H.D., Yoon,K., Shin,Y.J., Kim,J. and Lee,S.Y.
  TITLE     PIAS3 suppresses NF-kappaB-mediated transcription by interacting
            with the p65/RelA subunit
  JOURNAL   J. Biol. Chem. 279 (23), 24873-24880 (2004)
   PUBMED   15140884
  REMARK    GeneRIF: the transcriptional activity of p65 is suppressed by PIAS3
REFERENCE   6  (bases 1 to 1760)
  AUTHORS   Mattioli,I., Sebald,A., Bucher,C., Charles,R.P., Nakano,H., Doi,T.,
            Kracht,M. and Schmitz,M.L.
  TITLE     Transient and selective NF-kappa B p65 serine 536 phosphorylation
            induced by T cell costimulation is mediated by I kappa B kinase
            beta and controls the kinetics of p65 nuclear import
  JOURNAL   J. Immunol. 172 (10), 6336-6344 (2004)
   PUBMED   15128824
  REMARK    GeneRIF: Jurkat T cell costimulation-induced phosphorylation sites
            have been systematically mapped within the carboxyl-terminal half
            of the strongly trans-activating NF-kappa B p65 subunit; serine 536
            is identified as the main phosphorylation site.
REFERENCE   7  (bases 1 to 1760)
  AUTHORS   Liu,A., Hoffman,P.W., Lu,W. and Bai,G.
  TITLE     NF-kappaB site interacts with Sp factors and up-regulates the NR1
            promoter during neuronal differentiation
  JOURNAL   J. Biol. Chem. 279 (17), 17449-17458 (2004)
   PUBMED   14970236
  REMARK    GeneRIF: NF-kappaB positively regulates the NR1 promoter during
            neuronal differentiation via interacting mainly with Sp1/Sp3
REFERENCE   8  (bases 1 to 1760)
  AUTHORS   Marinari,B., Costanzo,A., Marzano,V., Piccolella,E. and Tuosto,L.
  TITLE     CD28 delivers a unique signal leading to the selective recruitment
            of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene
            promoters
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (16), 6098-6103 (2004)
   PUBMED   15079071
  REMARK    GeneRIF: transcription of CD28-induced genes is mediated by the
            specific recruitment of RelA and p52 NF-kappaB subunits to target
            promoters
REFERENCE   9  (bases 1 to 1760)
  AUTHORS   Takada,Y., Singh,S. and Aggarwal,B.B.
  TITLE     Identification of a p65 peptide that selectively inhibits NF-kappa
            B activation induced by various inflammatory stimuli and its role
            in down-regulation of NF-kappaB-mediated gene expression and
            up-regulation of apoptosis
  JOURNAL   J. Biol. Chem. 279 (15), 15096-15104 (2004)
   PUBMED   14711835
  REMARK    GeneRIF: the p65 peptide that can selectively inhibit NF-kappaB
            activation induced by various inflammatory stimuli, down-regulate
            NF-kappaB-mediated gene expression, and up-regulate apoptosis
REFERENCE   10 (bases 1 to 1760)
  AUTHORS   McNulty,S.E., del Rosario,R., Cen,D., Meyskens,F.L. Jr. and Yang,S.
  TITLE     Comparative expression of NFkappaB proteins in melanocytes of
            normal skin vs. benign intradermal naevus and human metastatic
            melanoma biopsies
  JOURNAL   Pigment Cell Res. 17 (2), 173-180 (2004)
   PUBMED   15016307
  REMARK    GeneRIF: RelA expression is altered in metastatic melanoma cells
            and has a role in deregulated NFkappaB signaling
REFERENCE   11 (bases 1 to 1760)
  AUTHORS   Yang,G.F., Deng,C.S., Xiong,Y.Y., Gong,L.L., Wang,B.C. and Luo,J.
  TITLE     Expression of nuclear factor-kappa B and target genes in gastric
            precancerous lesions and adenocarcinoma: association with
            Helicobactor pylori cagA (+) infection
  JOURNAL   World J. Gastroenterol. 10 (4), 491-496 (2004)
   PUBMED   14966904
  REMARK    GeneRIF: Intestinal type gastric carcinoma is strongly associated
            with high expression of c-myc, cyclinD1 and bcl-xl through
            NF-kappaB/p65 activated by H pylori cagA
REFERENCE   12 (bases 1 to 1760)
  AUTHORS   Kim,S., Domon-Dell,C., Kang,J., Chung,D.H., Freund,J.N. and
            Evers,B.M.
  TITLE     Down-regulation of the tumor suppressor PTEN by the tumor necrosis
            factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing
            kinase/NF-kappaB pathway is linked to a default IkappaB-alpha
            autoregulatory loop
  JOURNAL   J. Biol. Chem. 279 (6), 4285-4291 (2004)
   PUBMED   14623898
  REMARK    GeneRIF: overexpression of TNF-alpha downstream signaling targets,
            nuclear factor-kappaB (NF-kappaB)-inducing kinase (NIK) and p65
            nuclear factor NF-kappaB, lowers PTEN expression
REFERENCE   13 (bases 1 to 1760)
  AUTHORS   Monteleone,G., Mann,J., Monteleone,I., Vavassori,P., Bremner,R.,
            Fantini,M., Del Vecchio Blanco,G., Tersigni,R., Alessandroni,L.,
            Mann,D., Pallone,F. and MacDonald,T.T.
  TITLE     A failure of transforming growth factor-beta1 negative regulation
            maintains sustained NF-kappaB activation in gut inflammation
  JOURNAL   J. Biol. Chem. 279 (6), 3925-3932 (2004)
   PUBMED   14600158
  REMARK    GeneRIF: TGF-beta1 is a negative regulator of NF-kappaB p65
            activation in the gut
REFERENCE   14 (bases 1 to 1760)
  AUTHORS   Yoshida,Y., Kumar,A., Koyama,Y., Peng,H., Arman,A., Boch,J.A. and
            Auron,P.E.
  TITLE     Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via
            a unique TRAF6- and p65-dependent mechanism
  JOURNAL   J. Biol. Chem. 279 (3), 1768-1776 (2004)
   PUBMED   14593105
  REMARK    GeneRIF: STAT3/NF-kappaB p65 cross-talk activated by IL-1 via
            TRAF6.
REFERENCE   15 (bases 1 to 1760)
  AUTHORS   Wang,W., Luo,H.S. and Yu,B.P.
  TITLE     Expression of NF-kappaB and human telomerase reverse transcriptase
            in gastric cancer and precancerous lesions
  JOURNAL   World J. Gastroenterol. 10 (2), 177-181 (2004)
   PUBMED   14716817
  REMARK    GeneRIF: NF-kappaBp65 and hTERT expressions are upregulated at the
            early stage of gastric carcinogenesis.
REFERENCE   16 (bases 1 to 1760)
  AUTHORS   Valanciute,A., le Gouvello,S., Solhonne,B., Pawlak,A., Grimbert,P.,
            Lyonnet,L., Hue,S., Lang,P., Remy,P., Salomon,R., Bensman,A.,
            Guellaen,G. and Sahali,D.
  TITLE     NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal
            change nephrotic syndrome
  JOURNAL   J. Immunol. 172 (1), 688-698 (2004)
   PUBMED   14688382
  REMARK    GeneRIF: RelA blunts IL-4 induction in T cells during the relapse
            in patients with minimal change nephrotic syndrome.
REFERENCE   17 (bases 1 to 1760)
  AUTHORS   Lusic,M., Marcello,A., Cereseto,A. and Giacca,M.
  TITLE     Regulation of HIV-1 gene expression by histone acetylation and
            factor recruitment at the LTR promoter
  JOURNAL   EMBO J. 22 (24), 6550-6561 (2003)
   PUBMED   14657027
REFERENCE   18 (bases 1 to 1760)
  AUTHORS   Sweet,T., Khalili,K., Sawaya,B.E. and Amini,S.
  TITLE     Identification of a novel protein from glial cells based on its
            ability to interact with NF-kappaB subunits
  JOURNAL   J. Cell. Biochem. 90 (5), 884-891 (2003)
   PUBMED   14624448
REFERENCE   19 (bases 1 to 1760)
  AUTHORS   Ryo,A., Suizu,F., Yoshida,Y., Perrem,K., Liou,Y.C., Wulf,G.,
            Rottapel,R., Yamaoka,S. and Lu,K.P.
  TITLE     Regulation of NF-kappaB signaling by Pin1-dependent prolyl
            isomerization and ubiquitin-mediated proteolysis of p65/RelA
  JOURNAL   Mol. Cell 12 (6), 1413-1426 (2003)
   PUBMED   14690596
  REMARK    GeneRIF: Data show that NF-kappaB function is regulated by
            Pin1-mediated prolyl isomerization and ubiquitin-mediated
            proteolysis of its p65/RelA subunit.
REFERENCE   20 (bases 1 to 1760)
  AUTHORS   Chen,F., Wang,M., O'Connor,J.P., He,M., Tripathi,T. and
            Harrison,L.E.
  TITLE     Phosphorylation of PPARgamma via active ERK1/2 leads to its
            physical association with p65 and inhibition of NF-kappabeta
  JOURNAL   J. Cell. Biochem. 90 (4), 732-744 (2003)
   PUBMED   14587029
  REMARK    GeneRIF: Ciglitazone induced phosphorylation of PPARgamma through
            the MAP kinase pathway provides a potential regulatory mechanism
            for PPARgamma's physical interaction with p65
REFERENCE   21 (bases 1 to 1760)
  AUTHORS   Sakurai,H., Suzuki,S., Kawasaki,N., Nakano,H., Okazaki,T.,
            Chino,A., Doi,T. and Saiki,I.
  TITLE     Tumor necrosis factor-alpha-induced IKK phosphorylation of
            NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5,
            and TAK1 signaling pathway
  JOURNAL   J. Biol. Chem. 278 (38), 36916-36923 (2003)
   PUBMED   12842894
  REMARK    GeneRIF: IkappaB and NF-kappaB are substrates for the IKK complex
            in the activation of NF-kappaB
REFERENCE   22 (bases 1 to 1760)
  AUTHORS   Liptay,S., Weber,C.K., Ludwig,L., Wagner,M., Adler,G. and
            Schmid,R.M.
  TITLE     Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel
            activity in pancreatic cancer
  JOURNAL   Int. J. Cancer 105 (6), 735-746 (2003)
   PUBMED   12767057
  REMARK    GeneRIF: Mitogenic and antiapoptotic role of constitutive
            NF-kappaB/Rel activity in pancreatic cancer.
REFERENCE   23 (bases 1 to 1760)
  AUTHORS   Asamitsu,K., Tetsuka,T., Kanazawa,S. and Okamoto,T.
  TITLE     RING finger protein AO7 supports NF-kappaB-mediated transcription
            by interacting with the transactivation domain of the p65 subunit
  JOURNAL   J. Biol. Chem. 278 (29), 26879-26887 (2003)
   PUBMED   12748188
  REMARK    GeneRIF: RING finger protein AO7 supports NF-kappaB-mediated
            transcription by interacting with the transactivation domain of the
            p65 subunit.
REFERENCE   24 (bases 1 to 1760)
  AUTHORS   Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B.
  TITLE     SINK is a p65-interacting negative regulator of NF-kappaB-dependent
            transcription
  JOURNAL   J. Biol. Chem. 278 (29), 27072-27079 (2003)
   PUBMED   12736262
  REMARK    GeneRIF: SINK specifically interacted with the NF-kappaB
            transactivator p65 and inhibited p65 phosphorylation
REFERENCE   25 (bases 1 to 1760)
  AUTHORS   Benezra,M., Chevallier,N., Morrison,D.J., MacLachlan,T.K.,
            El-Deiry,W.S. and Licht,J.D.
  TITLE     BRCA1 augments transcription by the NF-kappaB transcription factor
            by binding to the Rel domain of the p65/RelA subunit
  JOURNAL   J. Biol. Chem. 278 (29), 26333-26341 (2003)
   PUBMED   12700228
  REMARK    GeneRIF: p65/RelA, one of the two subunits of the transcription
            factor NF-kappaB, binds to the BRCA1 protein.
REFERENCE   26 (bases 1 to 1760)
  AUTHORS   Helbig,G., Christopherson,K.W. II, Bhat-Nakshatri,P., Kumar,S.,
            Kishimoto,H., Miller,K.D., Broxmeyer,H.E. and Nakshatri,H.
  TITLE     NF-kappaB promotes breast cancer cell migration and metastasis by
            inducing the expression of the chemokine receptor CXCR4
  JOURNAL   J. Biol. Chem. 278 (24), 21631-21638 (2003)
   PUBMED   12690099
  REMARK    GeneRIF: NF-kappaB has a role in the migration and the
            organ-specific homing of metastatic breast cancer cells
REFERENCE   27 (bases 1 to 1760)
  AUTHORS   Kirchner,D., Duyster,J., Ottmann,O., Schmid,R.M., Bergmann,L. and
            Munzert,G.
  TITLE     Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation
  JOURNAL   Exp. Hematol. 31 (6), 504-511 (2003)
   PUBMED   12829026
  REMARK    GeneRIF: Primary CML blasts showed constitutive p65/RelA
            NF-kappaB/Rel DNA binding activity
REFERENCE   28 (bases 1 to 1760)
  AUTHORS   Saccani,S., Pantano,S. and Natoli,G.
  TITLE     Modulation of NF-kappaB activity by exchange of dimers
  JOURNAL   Mol. Cell 11 (6), 1563-1574 (2003)
   PUBMED   12820969
  REMARK    GeneRIF: During dendritic cell maturation, rapidly activated dimers
            (e.g.,RelA) bound to a subset of target promoters are gradually
            replaced by slowly activated dimers (e.g., RelB).
REFERENCE   29 (bases 1 to 1760)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   30 (bases 1 to 1760)
  AUTHORS   Hinata,K., Gervin,A.M., Jennifer Zhang,Y. and Khavari,P.A.
  TITLE     Divergent gene regulation and growth effects by NF-kappa B in
            epithelial and mesenchymal cells of human skin
  JOURNAL   Oncogene 22 (13), 1955-1964 (2003)
   PUBMED   12673201
  REMARK    GeneRIF: NF-kappa B induced proinflammatory & antiapoptotic genes
            in epithelial and mesenchymal cells of human skin.  In
            keratinocytes, not fibroblasts, it induced p21(CIP1). GIF levls
            increased by NF-kappa B in both, but inhibited growth only in
            keratinocytes.
REFERENCE   31 (bases 1 to 1760)
  AUTHORS   Lee,Y., Allport,V., Sykes,A., Lindstrom,T., Slater,D. and
            Bennett,P.
  TITLE     The effects of labour and of interleukin 1 beta upon the expression
            of nuclear factor kappa B related proteins in human amnion
  JOURNAL   Mol. Hum. Reprod. 9 (4), 213-218 (2003)
   PUBMED   12651903
  REMARK    GeneRIF: Data show that increased expression of nuclear
            factor-kappaB (NF-kB) in amnion during labor is associated with an
            increase in the expression of NF-kBp65 and the NF-kB binding
            proteins IkBa, IkBb-1 and IkBb-2.
REFERENCE   32 (bases 1 to 1760)
  AUTHORS   Fujioka,S., Sclabas,G.M., Schmidt,C., Niu,J., Frederick,W.A.,
            Dong,Q.G., Abbruzzese,J.L., Evans,D.B., Baker,C. and Chiao,P.J.
  TITLE     Inhibition of constitutive NF-kappa B activity by I kappa B alpha M
            suppresses tumorigenesis
  JOURNAL   Oncogene 22 (9), 1365-1370 (2003)
   PUBMED   12618762
  REMARK    GeneRIF: Inhibiting constitutive NF-kappa B activity by expressing
            I kappa B alpha M suppressed the tumorigenicity of a nonmetastatic
            human pancreatic cancer cell line, PANC-1, in an orthotopic nude
            mouse model.
REFERENCE   33 (bases 1 to 1760)
  AUTHORS   Minami,T., Abid,M.R., Zhang,J., King,G., Kodama,T. and Aird,W.C.
  TITLE     Thrombin stimulation of vascular adhesion molecule-1 in endothelial
            cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and
            PKC-zeta-GATA signaling pathways
  JOURNAL   J. Biol. Chem. 278 (9), 6976-6984 (2003)
   PUBMED   12493764
  REMARK    GeneRIF: Protein kinase C delta-NF-kappaB signaling regulates VCAM1
            stimulation by thrombin in endothelial cells
REFERENCE   34 (bases 1 to 1760)
  AUTHORS   Majumdar,S. and Aggarwal,B.B.
  TITLE     Adenosine suppresses activation of nuclear factor-kappaB
            selectively induced by tumor necrosis factor in different cell
            types
  JOURNAL   Oncogene 22 (8), 1206-1218 (2003)
   PUBMED   12606947
  REMARK    GeneRIF: Adenosine selectively suppresses TNF-induced NF-kappaB
            activation, which may contribute to its role in suppression of
            inflammation and of the immune system.
REFERENCE   35 (bases 1 to 1760)
  AUTHORS   Wong,B.C., Jiang,X., Fan,X.M., Lin,M.C., Jiang,S.H., Lam,S.K. and
            Kung,H.F.
  TITLE     Suppression of RelA/p65 nuclear translocation independent of
            IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric
            cancer
  JOURNAL   Oncogene 22 (8), 1189-1197 (2003)
   PUBMED   12606945
  REMARK    GeneRIF: The translocation of RelA/p65 was investigated using
            Western blotting and immunocytochemistry. the COX-2 inhibitor SC236
            worked directly through suppressing nuclear translocation of
            RelA/p65.
REFERENCE   36 (bases 1 to 1760)
  AUTHORS   Espinosa,L., Ingles-Esteve,J., Robert-Moreno,A. and Bigas,A.
  TITLE     IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear
            corepressors: cross-talk between Notch and NFkappaB pathways
  JOURNAL   Mol. Biol. Cell 14 (2), 491-502 (2003)
   PUBMED   12589049
  REMARK    GeneRIF: IkappaBalpha and p65 have roles in regulating the
            cytoplasmic shuttling of nuclear corepressors
REFERENCE   37 (bases 1 to 1760)
  AUTHORS   Okazaki,T., Sakon,S., Sasazuki,T., Sakurai,H., Doi,T., Yagita,H.,
            Okumura,K. and Nakano,H.
  TITLE     Phosphorylation of serine 276 is essential for p65 NF-kappaB
            subunit-dependent cellular responses
  JOURNAL   Biochem. Biophys. Res. Commun. 300 (4), 807-812 (2003)
   PUBMED   12559944
  REMARK    GeneRIF: S276 is the major phosphorylation site of p65 and its
            phosphorylation is essential for p65-dependent cellular responses
REFERENCE   38 (bases 1 to 1760)
  AUTHORS   Kiernan,R., Bres,V., Ng,R.W., Coudart,M.P., El Messaoudi,S.,
            Sardet,C., Jin,D.Y., Emiliani,S. and Benkirane,M.
  TITLE     Post-activation turn-off of NF-kappa B-dependent transcription is
            regulated by acetylation of p65
  JOURNAL   J. Biol. Chem. 278 (4), 2758-2766 (2003)
   PUBMED   12419806
  REMARK    GeneRIF: acetylation of p65 plays a key role in
            IkappaBetaalpha-mediated attenuation of NF-kappaBeta
            transcriptional activity which is an important process that
            restores the latent state in post-induced cells
REFERENCE   39 (bases 1 to 1760)
  AUTHORS   Schooley,K., Zhu,P., Dower,S.K. and Qwarnstrom,E.E.
  TITLE     Regulation of nuclear translocation of nuclear factor-kappaB relA:
            evidence for complex dynamics at the single-cell level
  JOURNAL   Biochem. J. 369 (Pt 2), 331-339 (2003)
   PUBMED   12350227
  REMARK    GeneRIF: Data show that interleukin-1 induces nuclear transport of
            RelA.
REFERENCE   40 (bases 1 to 1760)
  AUTHORS   Jiang,X., Takahashi,N., Matsui,N., Tetsuka,T. and Okamoto,T.
  TITLE     The NF-kappa B activation in lymphotoxin beta receptor signaling
            depends on the phosphorylation of p65 at serine 536
  JOURNAL   J. Biol. Chem. 278 (2), 919-926 (2003)
   PUBMED   12419817
  REMARK    GeneRIF: The NF-kappa B activation in lymphotoxin beta receptor
            signaling depends on the phosphorylation of p65 at serine 536.
REFERENCE   41 (bases 1 to 1760)
  AUTHORS   Akiyama,M., Hideshima,T., Hayashi,T., Tai,Y.T., Mitsiades,C.S.,
            Mitsiades,N., Chauhan,D., Richardson,P., Munshi,N.C. and
            Anderson,K.C.
  TITLE     Nuclear factor-kappaB p65 mediates tumor necrosis factor
            alpha-induced nuclear translocation of telomerase reverse
            transcriptase protein
  JOURNAL   Cancer Res. 63 (1), 18-21 (2003)
   PUBMED   12517770
  REMARK    GeneRIF: mediates tumor necrosis factor alpha-induced nuclear
            translocation of telomerase reverse transcriptase protein
REFERENCE   42 (bases 1 to 1760)
  AUTHORS   Sheng,W.S., Hu,S., Lokensgard,J.R. and Peterson,P.K.
  TITLE     U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant
            protein-1 (CCL2) production by human astrocytes
  JOURNAL   Biochem. Pharmacol. 65 (1), 9-14 (2003)
   PUBMED   12473373
REFERENCE   43 (bases 1 to 1760)
  AUTHORS   Anderson,L.A. and Perkins,N.D.
  TITLE     Regulation of RelA (p65) function by the large subunit of
            replication factor C
  JOURNAL   Mol. Cell. Biol. 23 (2), 721-732 (2003)
   PUBMED   12509469
  REMARK    GeneRIF: RelA expression is regulated by replication factor C
            (p140)
REFERENCE   44 (bases 1 to 1760)
  AUTHORS   Toborek,M., Lee,Y.W., Pu,H., Malecki,A., Flora,G., Garrido,R.,
            Hennig,B., Bauer,H.C. and Nath,A.
  TITLE     HIV-Tat protein induces oxidative and inflammatory pathways in
            brain endothelium
  JOURNAL   J. Neurochem. 84 (1), 169-179 (2003)
   PUBMED   12485413
REFERENCE   45 (bases 1 to 1760)
  AUTHORS   Pieper,G.M., Olds,C.L., Bub,J.D. and Lindholm,P.F.
  TITLE     Transfection of human endothelial cells with HIV-1 tat gene
            activates NF-kappa B and enhances monocyte adhesion
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 283 (6), H2315-H2321 (2002)
   PUBMED   12427593
REFERENCE   46 (bases 1 to 1760)
  AUTHORS   Nishi,T., Shimizu,N., Hiramoto,M., Sato,I., Yamaguchi,Y.,
            Hasegawa,M., Aizawa,S., Tanaka,H., Kataoka,K., Watanabe,H. and
            Handa,H.
  TITLE     Spatial redox regulation of a critical cysteine residue of NF-kappa
            B in vivo
  JOURNAL   J. Biol. Chem. 277 (46), 44548-44556 (2002)
   PUBMED   12213807
  REMARK    GeneRIF: NF-kappaB is regulated by the redox factor Ref-1 in the
            nucleus
REFERENCE   47 (bases 1 to 1760)
  AUTHORS   Bennasser,Y., Badou,A., Tkaczuk,J. and Bahraoui,E.
  TITLE     Signaling pathways triggered by HIV-1 Tat in human monocytes to
            induce TNF-alpha
  JOURNAL   Virology 303 (1), 174-180 (2002)
   PUBMED   12482669
REFERENCE   48 (bases 1 to 1760)
  AUTHORS   Liu,X., Jana,M., Dasgupta,S., Koka,S., He,J., Wood,C. and Pahan,K.
  TITLE     Human immunodeficiency virus type 1 (HIV-1) tat induces
            nitric-oxide synthase in human astroglia
  JOURNAL   J. Biol. Chem. 277 (42), 39312-39319 (2002)
   PUBMED   12167619
REFERENCE   49 (bases 1 to 1760)
  AUTHORS   Iordanskiy,S., Iordanskaya,T., Quivy,V., Van Lint,C. and
            Bukrinsky,M.
  TITLE     B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven
            transcription through suppression of NF-kappaB p65 subunit activity
  JOURNAL   Virology 302 (1), 195-206 (2002)
   PUBMED   12429528
  REMARK    GeneRIF: B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven
            transcription through suppression of NF-kappaB p65 subunit activity
REFERENCE   50 (bases 1 to 1760)
  AUTHORS   Drechsler,Y., Chavan,S., Catalano,D., Mandrekar,P. and Szabo,G.
  TITLE     FcgammaR cross-linking mediates NF-kappaB activation, reduced
            antigen presentation capacity, and decreased IL-12 production in
            monocytes without modulation of myeloid dendritic cell development
  JOURNAL   J. Leukoc. Biol. 72 (4), 657-667 (2002)
   PUBMED   12377934
  REMARK    GeneRIF: cross-linking FcgammaRI and -RII but not FcgammaRIII
            activates transcription factor NF-kappaB(p65)
REFERENCE   51 (bases 1 to 1760)
  AUTHORS   Chapman,N.R., Webster,G.A., Gillespie,P.J., Wilson,B.J.,
            Crouch,D.H. and Perkins,N.D.
  TITLE     A novel form of the RelA nuclear factor kappaB subunit is induced
            by and forms a complex with the proto-oncogene c-Myc
  JOURNAL   Biochem. J. 366 (Pt 2), 459-469 (2002)
   PUBMED   12027803
  REMARK    GeneRIF: A novel form is induced by and forms a complex with the
            proto-oncogene c-Myc
REFERENCE   52 (bases 1 to 1760)
  AUTHORS   Bernard,D., Monte,D., Vandenbunder,B. and Abbadie,C.
  TITLE     The c-Rel transcription factor can both induce and inhibit
            apoptosis in the same cells via the upregulation of MnSOD
  JOURNAL   Oncogene 21 (28), 4392-4402 (2002)
   PUBMED   12080470
  REMARK    GeneRIF: C-Rel can both induce and inhibit apoptosis in HeLa cells
            by upregulation of MnSOD
REFERENCE   53 (bases 1 to 1760)
  AUTHORS   Gu,L., Findley,H.W. and Zhou,M.
  TITLE     MDM2 induces NF-kappaB/p65 expression transcriptionally through
            Sp1-binding sites: a novel, p53-independent role of MDM2 in
            doxorubicin resistance in acute lymphoblastic leukemia
  JOURNAL   Blood 99 (9), 3367-3375 (2002)
   PUBMED   11964305
  REMARK    GeneRIF: MDM2 can induce expression of the p65 subunit of NF-kappaB
REFERENCE   54 (bases 1 to 1760)
  AUTHORS   Cota-Gomez,A., Flores,N.C., Cruz,C., Casullo,A., Aw,T.Y.,
            Ichikawa,H., Schaack,J., Scheinman,R. and Flores,S.C.
  TITLE     The human immunodeficiency virus-1 Tat protein activates human
            umbilical vein endothelial cell E-selectin expression via an
            NF-kappa B-dependent mechanism
  JOURNAL   J. Biol. Chem. 277 (17), 14390-14399 (2002)
   PUBMED   11827962
REFERENCE   55 (bases 1 to 1760)
  AUTHORS   Hu,C.D., Chinenov,Y. and Kerppola,T.K.
  TITLE     Visualization of interactions among bZIP and Rel family proteins in
            living cells using bimolecular fluorescence complementation
  JOURNAL   Mol. Cell 9 (4), 789-798 (2002)
   PUBMED   11983170
REFERENCE   56 (bases 1 to 1760)
  AUTHORS   Bottex-Gauthier,C., Pollet,S., Favier,A. and Vidal,D.R.
  TITLE     The Rel/NF-kappa-B transcription factors: complex role in cell
            regulation
  JOURNAL   Pathol. Biol. 50 (3), 204-211 (2002)
   PUBMED   11980335
  REMARK    GeneRIF: NF-KB could be considered as a coordinating element in the
            body's response to stress, infection or inflammation, and it may be
            a good therapeutic target.
REFERENCE   57 (bases 1 to 1760)
  AUTHORS   Carpenter,L.R., Moy,J.N. and Roebuck,K.A.
  TITLE     Respiratory syncytial virus and TNF alpha induction of chemokine
            gene expression involves differential activation of Rel A and
            NF-kappa B1
  JOURNAL   (er) BMC Infect. Dis. 2 (1), 5 (2002)
   PUBMED   11922866
  REMARK    GeneRIF: Respiratory syncytial virus induction of chemokine gene
            expression involves a redox-sensitive NF-kappaB1 signaling
            mechanism that differs from that mediated by TNF alpha in that it
            involves predominantly the RelA subunit of NF-kappaB.
REFERENCE   58 (bases 1 to 1760)
  AUTHORS   Gan,H., Ouyang,Q., Chen,Y. and Xia,Q.
  TITLE     Activation of nuclear factor-kappaB and effects of
            anti-inflammatory treatment thereon in intestinal mucosa of
            patients with ulcerative colitis
  JOURNAL   Zhonghua Yi Xue Za Zhi 82 (6), 384-388 (2002)
   PUBMED   11953203
  REMARK    GeneRIF: activation and expression of nuclear factor-kappaB
            (NF-kappaB) and effects of anti-inflammatory treatment on NF-kappaB
            in the intestinal mucosa of patients with ulcerative colitis (UC)
REFERENCE   59 (bases 1 to 1760)
  AUTHORS   Furia,B., Deng,L., Wu,K., Baylor,S., Kehn,K., Li,H., Donnelly,R.,
            Coleman,T. and Kashanchi,F.
  TITLE     Enhancement of nuclear factor-kappa B acetylation by coactivator
            p300 and HIV-1 Tat proteins
  JOURNAL   J. Biol. Chem. 277 (7), 4973-4980 (2002)
   PUBMED   11739381
REFERENCE   60 (bases 1 to 1760)
  AUTHORS   Kino,T., Slobodskaya,O., Pavlakis,G.N. and Chrousos,G.P.
  TITLE     Nuclear receptor coactivator p160 proteins enhance the HIV-1 long
            terminal repeat promoter by bridging promoter-bound factors and the
            Tat-P-TEFb complex
  JOURNAL   J. Biol. Chem. 277 (4), 2396-2405 (2002)
   PUBMED   11704662
REFERENCE   61 (bases 1 to 1760)
  AUTHORS   Vider,J., Laaksonen,D.E., Kilk,A., Atalay,M., Lehtmaa,J., Zilmer,M.
            and Sen,C.K.
  TITLE     Physical exercise induces activation of NF-kappaB in human
            peripheral blood lymphocytes
  JOURNAL   Antioxid. Redox Signal. 3 (6), 1131-1137 (2001)
   PUBMED   11813986
  REMARK    GeneRIF: Physical exercise induces activation of NF-kappaB in human
            peripheral blood lymphocytes
REFERENCE   62 (bases 1 to 1760)
  AUTHORS   Bruce-Keller,A.J., Barger,S.W., Moss,N.I., Pham,J.T., Keller,J.N.
            and Nath,A.
  TITLE     Pro-inflammatory and pro-oxidant properties of the HIV protein Tat
            in a microglial cell line: attenuation by 17 beta-estradiol
  JOURNAL   J. Neurochem. 78 (6), 1315-1324 (2001)
   PUBMED   11579140
REFERENCE   63 (bases 1 to 1760)
  AUTHORS   Li,X., Josef,J. and Marasco,W.A.
  TITLE     Hiv-1 Tat can substantially enhance the capacity of NIK to induce
            IkappaB degradation
  JOURNAL   Biochem. Biophys. Res. Commun. 286 (3), 587-594 (2001)
   PUBMED   11511100
REFERENCE   64 (bases 1 to 1760)
  AUTHORS   Chiao,C., Bader,T., Stenger,J.E., Baldwin,W., Brady,J. and
            Barrett,J.C.
  TITLE     HIV type 1 Tat inhibits tumor necrosis factor alpha-induced
            repression of tumor necrosis factor receptor p55 and amplifies
            tumor necrosis factor alpha activity in stably tat-transfected HeLa
            Cells
  JOURNAL   AIDS Res. Hum. Retroviruses 17 (12), 1125-1132 (2001)
   PUBMED   11522182
REFERENCE   65 (bases 1 to 1760)
  AUTHORS   Ehret,A., Li-Weber,M., Frank,R. and Krammer,P.H.
  TITLE     The effect of HIV-1 regulatory proteins on cellular genes:
            derepression of the IL-2 promoter by Tat
  JOURNAL   Eur. J. Immunol. 31 (6), 1790-1799 (2001)
   PUBMED   11385624
REFERENCE   66 (bases 1 to 1760)
  AUTHORS   Patrizio,M., Colucci,M. and Levi,G.
  TITLE     Human immunodeficiency virus type 1 Tat protein decreases cyclic
            AMP synthesis in rat microglia cultures
  JOURNAL   J. Neurochem. 77 (2), 399-407 (2001)
   PUBMED   11299302
REFERENCE   67 (bases 1 to 1760)
  AUTHORS   Visentin,S., Renzi,M. and Levi,G.
  TITLE     Altered outward-rectifying K(+) current reveals microglial
            activation induced by HIV-1 Tat protein
  JOURNAL   Glia 33 (3), 181-190 (2001)
   PUBMED   11241736
REFERENCE   68 (bases 1 to 1760)
  AUTHORS   Mahieux,R., Lambert,P.F., Agbottah,E., Halanski,M.A., Deng,L.,
            Kashanchi,F. and Brady,J.N.
  TITLE     Cell cycle regulation of human interleukin-8 gene expression by the
            human immunodeficiency virus type 1 Tat protein
  JOURNAL   J. Virol. 75 (4), 1736-1743 (2001)
   PUBMED   11160671
REFERENCE   69 (bases 1 to 1760)
  AUTHORS   Yamina,B., Xavier,C., Marc,M., Catherine,L., Abdallah,B. and
            Bahraoui,E.
  TITLE     HIV-1 Tat protein induces IL-10 production by human monocytes:
            implications of the PKC and calcium pathway
  JOURNAL   J. Soc. Biol. 195 (3), 319-326 (2001)
   PUBMED   11833470
REFERENCE   70 (bases 1 to 1760)
  AUTHORS   Badou,A., Bennasser,Y., Moreau,M., Leclerc,C., Benkirane,M. and
            Bahraoui,E.
  TITLE     Tat protein of human immunodeficiency virus type 1 induces
            interleukin-10 in human peripheral blood monocytes: implication of
            protein kinase C-dependent pathway
  JOURNAL   J. Virol. 74 (22), 10551-10562 (2000)
   PUBMED   11044099
REFERENCE   71 (bases 1 to 1760)
  AUTHORS   Mozaffarian,N., Casadevall,A. and Berman,J.W.
  TITLE     Inhibition of human endothelial cell chemokine production by the
            opportunistic fungal pathogen Cryptococcus neoformans
  JOURNAL   J. Immunol. 165 (3), 1541-1547 (2000)
   PUBMED   10903762
REFERENCE   72 (bases 1 to 1760)
  AUTHORS   McKay,L.I. and Cidlowski,J.A.
  TITLE     CBP (CREB binding protein) integrates NF-kappaB (nuclear
            factor-kappaB) and glucocorticoid receptor physical interactions
            and antagonism
  JOURNAL   Mol. Endocrinol. 14 (8), 1222-1234 (2000)
   PUBMED   10935546
REFERENCE   73 (bases 1 to 1760)
  AUTHORS   Schulte,R., Grassl,G.A., Preger,S., Fessele,S., Jacobi,C.A.,
            Schaller,M., Nelson,P.J. and Autenrieth,I.B.
  TITLE     Yersinia enterocolitica invasin protein triggers IL-8 production in
            epithelial cells via activation of Rel p65-p65 homodimers
  JOURNAL   FASEB J. 14 (11), 1471-1484 (2000)
   PUBMED   10928981
REFERENCE   74 (bases 1 to 1760)
  AUTHORS   Yamit-Hezi,A., Nir,S., Wolstein,O. and Dikstein,R.
  TITLE     Interaction of TAFII105 with selected p65/RelA dimers is associated
            with activation of subset of NF-kappa B genes
  JOURNAL   J. Biol. Chem. 275 (24), 18180-18187 (2000)
   PUBMED   10849440
REFERENCE   75 (bases 1 to 1760)
  AUTHORS   Anto,R.J., Maliekal,T.T. and Karunagaran,D.
  TITLE     L-929 cells harboring ectopically expressed RelA resist
            curcumin-induced apoptosis
  JOURNAL   J. Biol. Chem. 275 (21), 15601-15604 (2000)
   PUBMED   10747850
REFERENCE   76 (bases 1 to 1760)
  AUTHORS   Manna,S.K. and Aggarwal,B.B.
  TITLE     Differential requirement for p56lck in HIV-tat versus TNF-induced
            cellular responses: effects on NF-kappa B, activator protein-1,
            c-Jun N-terminal kinase, and apoptosis
  JOURNAL   J. Immunol. 164 (10), 5156-5166 (2000)
   PUBMED   10799874
REFERENCE   77 (bases 1 to 1760)
  AUTHORS   Li-Weber,M., Laur,O., Dern,K. and Krammer,P.H.
  TITLE     T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas)
            ligand transcription involves NF-kappaB
  JOURNAL   Eur. J. Immunol. 30 (2), 661-670 (2000)
   PUBMED   10671224
REFERENCE   78 (bases 1 to 1760)
  AUTHORS   Lim,S.P. and Garzino-Demo,A.
  TITLE     The human immunodeficiency virus type 1 Tat protein up-regulates
            the promoter activity of the beta-chemokine monocyte
            chemoattractant protein 1 in the human astrocytoma cell line U-87
            MG: role of SP-1, AP-1, and NF-kappaB consensus sites
  JOURNAL   J. Virol. 74 (4), 1632-1640 (2000)
   PUBMED   10644332
REFERENCE   79 (bases 1 to 1760)
  AUTHORS   Rohr,O., Schwartz,C., Hery,C., Aunis,D., Tardieu,M. and
            Schaeffer,E.
  TITLE     The nuclear receptor chicken ovalbumin upstream promoter
            transcription factor interacts with HIV-1 Tat and stimulates viral
            replication in human microglial cells
  JOURNAL   J. Biol. Chem. 275 (4), 2654-2660 (2000)
   PUBMED   10644726
REFERENCE   80 (bases 1 to 1760)
  AUTHORS   Kumar,A., Dhawan,S., Mukhopadhyay,A. and Aggarwal,B.B.
  TITLE     Human immunodeficiency virus-1-tat induces matrix
            metalloproteinase-9 in monocytes through protein tyrosine
            phosphatase-mediated activation of nuclear transcription factor
            NF-kappaB
  JOURNAL   FEBS Lett. 462 (1-2), 140-144 (1999)
   PUBMED   10580107
REFERENCE   81 (bases 1 to 1760)
  AUTHORS   Blazquez,M.V., Macho,A., Ortiz,C., Lucena,C., Lopez-Cabrera,M.,
            Sanchez-Madrid,F. and Munoz,E.
  TITLE     Extracellular HIV type 1 Tat protein induces CD69 expression
            through NF-kappaB activation: possible correlation with cell
            surface Tat-binding proteins
  JOURNAL   AIDS Res. Hum. Retroviruses 15 (13), 1209-1218 (1999)
   PUBMED   10480634
REFERENCE   82 (bases 1 to 1760)
  AUTHORS   Polazzi,E., Levi,G. and Minghetti,L.
  TITLE     Human immunodeficiency virus type 1 Tat protein stimulates
            inducible nitric oxide synthase expression and nitric oxide
            production in microglial cultures
  JOURNAL   J. Neuropathol. Exp. Neurol. 58 (8), 825-831 (1999)
   PUBMED   10446807
REFERENCE   83 (bases 1 to 1760)
  AUTHORS   Demarchi,F., Gutierrez,M.I. and Giacca,M.
  TITLE     Human immunodeficiency virus type 1 tat protein activates
            transcription factor NF-kappaB through the cellular
            interferon-inducible, double-stranded RNA-dependent protein kinase,
            PKR
  JOURNAL   J. Virol. 73 (8), 7080-7086 (1999)
   PUBMED   10400814
REFERENCE   84 (bases 1 to 1760)
  AUTHORS   Boykins,R.A., Mahieux,R., Shankavaram,U.T., Gho,Y.S., Lee,S.F.,
            Hewlett,I.K., Wahl,L.M., Kleinman,H.K., Brady,J.N., Yamada,K.M. and
            Dhawan,S.
  TITLE     Cutting edge: a short polypeptide domain of HIV-1-Tat protein
            mediates pathogenesis
  JOURNAL   J. Immunol. 163 (1), 15-20 (1999)
   PUBMED   10384093
REFERENCE   85 (bases 1 to 1760)
  AUTHORS   Chen,F., Lu,Y., Castranova,V., Rojanasakul,Y., Miyahara,K.,
            Shizuta,Y., Vallyathan,V., Shi,X. and Demers,L.M.
  TITLE     Nitric oxide inhibits HIV tat-induced NF-kappaB activation
  JOURNAL   Am. J. Pathol. 155 (1), 275-284 (1999)
   PUBMED   10393859
REFERENCE   86 (bases 1 to 1760)
  AUTHORS   Macian,F. and Rao,A.
  TITLE     Reciprocal modulatory interaction between human immunodeficiency
            virus type 1 Tat and transcription factor NFAT1
  JOURNAL   Mol. Cell. Biol. 19 (5), 3645-3653 (1999)
   PUBMED   10207088
REFERENCE   87 (bases 1 to 1760)
  AUTHORS   Kundu,M., Ansari,S.A., Chepenik,L.G., Pomerantz,R.J., Khalili,K.,
            Rappaport,J. and Amini,S.
  TITLE     HIV-1 regulatory protein tat induces RNA binding proteins in
            central nervous system cells that associate with the viral
            trans-acting-response regulatory motif
  JOURNAL   J. Hum. Virol. 2 (2), 72-80 (1999)
   PUBMED   10225209
REFERENCE   88 (bases 1 to 1760)
  AUTHORS   Kelly,G.D., Ensoli,B., Gunthel,C.J. and Offermann,M.K.
  TITLE     Purified Tat induces inflammatory response genes in Kaposi's
            sarcoma cells
  JOURNAL   AIDS 12 (14), 1753-1761 (1998)
   PUBMED   9792375
REFERENCE   89 (bases 1 to 1760)
  AUTHORS   Mayne,M., Bratanich,A.C., Chen,P., Rana,F., Nath,A. and Power,C.
  TITLE     HIV-1 tat molecular diversity and induction of TNF-alpha:
            implications for HIV-induced neurological disease
  JOURNAL   Neuroimmunomodulation 5 (3-4), 184-192 (1998)
   PUBMED   9730685
REFERENCE   90 (bases 1 to 1760)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol. Cell. Biol. 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   91 (bases 1 to 1760)
  AUTHORS   Felzien,L.K., Woffendin,C., Hottiger,M.O., Subbramanian,R.A.,
            Cohen,E.A. and Nabel,G.J.
  TITLE     HIV transcriptional activation by the accessory protein, VPR, is
            mediated by the p300 co-activator
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (9), 5281-5286 (1998)
   PUBMED   9560267
REFERENCE   92 (bases 1 to 1760)
  AUTHORS   Kundu,M., Sharma,S., De Luca,A., Giordano,A., Rappaport,J.,
            Khalili,K. and Amini,S.
  TITLE     HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene
            expression in cells of glial origin
  JOURNAL   J. Biol. Chem. 273 (14), 8130-8136 (1998)
   PUBMED   9525916
REFERENCE   93 (bases 1 to 1760)
  AUTHORS   Ott,M., Lovett,J.L., Mueller,L. and Verdin,E.
  TITLE     Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated
            through NF-kappaB factors
  JOURNAL   J. Immunol. 160 (6), 2872-2880 (1998)
   PUBMED   9510190
REFERENCE   94 (bases 1 to 1760)
  AUTHORS   Chen,P., Mayne,M., Power,C. and Nath,A.
  TITLE     The Tat protein of HIV-1 induces tumor necrosis factor-alpha
            production. Implications for HIV-1-associated neurological diseases
  JOURNAL   J. Biol. Chem. 272 (36), 22385-22388 (1997)
   PUBMED   9278385
REFERENCE   95 (bases 1 to 1760)
  AUTHORS   Shatrov,V.A., Boelaert,J.R., Chouaib,S., Droge,W. and Lehmann,V.
  TITLE     Iron chelation decreases human immunodeficiency virus-1 Tat
            potentiated tumor necrosis factor-induced NF-kappa B activation in
            Jurkat cells
  JOURNAL   Eur. Cytokine Netw. 8 (1), 37-43 (1997)
   PUBMED   9110146
REFERENCE   96 (bases 1 to 1760)
  AUTHORS   Beauparlant,P., Kwon,H., Clarke,M., Lin,R., Sonenberg,N.,
            Wainberg,M. and Hiscott,J.
  TITLE     Transdominant mutants of I kappa B alpha block Tat-tumor necrosis
            factor synergistic activation of human immunodeficiency virus type
            1 gene expression and virus multiplication
  JOURNAL   J. Virol. 70 (9), 5777-5785 (1996)
   PUBMED   8709193
REFERENCE   97 (bases 1 to 1760)
  AUTHORS   Demarchi,F., d'Adda di Fagagna,F., Falaschi,A. and Giacca,M.
  TITLE     Activation of transcription factor NF-kappaB by the Tat protein of
            human immunodeficiency virus type 1
  JOURNAL   J. Virol. 70 (7), 4427-4437 (1996)
   PUBMED   8676466
REFERENCE   98 (bases 1 to 1760)
  AUTHORS   Ramazzotti,E., Vignoli,M., Re,M.C., Furlini,G. and La Placa,M.
  TITLE     Enhanced nuclear factor-kappa B activation induced by tumour
            necrosis factor-alpha in stably tat-transfected cells is associated
            with the presence of cell-surface-bound Tat protein
  JOURNAL   AIDS 10 (5), 455-461 (1996)
   PUBMED   8724035
REFERENCE   99 (bases 1 to 1760)
  AUTHORS   Conant,K., Ma,M., Nath,A. and Major,E.O.
  TITLE     Extracellular human immunodeficiency virus type 1 Tat protein is
            associated with an increase in both NF-kappa B binding and protein
            kinase C activity in primary human astrocytes
  JOURNAL   J. Virol. 70 (3), 1384-1389 (1996)
   PUBMED   8627654
REFERENCE   100 (bases 1 to 1760)
  AUTHORS   Harhaj,E., Blaney,J., Millhouse,S. and Sun,S.C.
  TITLE     Differential effects of I kappa B molecules on Tat-mediated
            transactivation of HIV-1 LTR
  JOURNAL   Virology 216 (1), 284-287 (1996)
   PUBMED   8615004
REFERENCE   101 (bases 1 to 1760)
  AUTHORS   Copeland,K.F., McKay,P.J. and Rosenthal,K.L.
  TITLE     Suppression of the human immunodeficiency virus long terminal
            repeat by CD8+ T cells is dependent on the NFAT-1 element
  JOURNAL   AIDS Res. Hum. Retroviruses 12 (2), 143-148 (1996)
   PUBMED   8834464
REFERENCE   102 (bases 1 to 1760)
  AUTHORS   Biswas,D.K., Salas,T.R., Wang,F., Ahlers,C.M., Dezube,B.J. and
            Pardee,A.B.
  TITLE     A Tat-induced auto-up-regulatory loop for superactivation of the
            human immunodeficiency virus type 1 promoter
  JOURNAL   J. Virol. 69 (12), 7437-7444 (1995)
   PUBMED   7494249
REFERENCE   103 (bases 1 to 1760)
  AUTHORS   Alcami,J., Lain de Lera,T., Folgueira,L., Pedraza,M.A.,
            Jacque,J.M., Bachelerie,F., Noriega,A.R., Hay,R.T., Harrich,D.,
            Gaynor,R.B. et al.
  TITLE     Absolute dependence on kappa B responsive elements for initiation
            and Tat-mediated amplification of HIV transcription in blood CD4 T
            lymphocytes
  JOURNAL   EMBO J. 14 (7), 1552-1560 (1995)
   PUBMED   7729429
REFERENCE   104 (bases 1 to 1760)
  AUTHORS   Westendorp,M.O., Shatrov,V.A., Schulze-Osthoff,K., Frank,R.,
            Kraft,M., Los,M., Krammer,P.H., Droge,W. and Lehmann,V.
  TITLE     HIV-1 Tat potentiates TNF-induced NF-kappa B activation and
            cytotoxicity by altering the cellular redox state
  JOURNAL   EMBO J. 14 (3), 546-554 (1995)
   PUBMED   7859743
REFERENCE   105 (bases 1 to 1760)
  AUTHORS   Taylor,J.P., Pomerantz,R.J., Oakes,J.W., Khalili,K. and Amini,S.
  TITLE     A CNS-enriched factor that binds to NF-kappa B and is required for
            interaction with HIV-1 tat
  JOURNAL   Oncogene 10 (2), 395-400 (1995)
   PUBMED   7838536
REFERENCE   106 (bases 1 to 1760)
  AUTHORS   Majello,B., De Luca,P., Hagen,G., Suske,G. and Lania,L.
  TITLE     Different members of the Sp1 multigene family exert opposite
            transcriptional regulation of the long terminal repeat of HIV-1
  JOURNAL   Nucleic Acids Res. 22 (23), 4914-4921 (1994)
   PUBMED   7800480
REFERENCE   107 (bases 1 to 1760)
  AUTHORS   Westendorp,M.O., Li-Weber,M., Frank,R.W. and Krammer,P.H.
  TITLE     Human immunodeficiency virus type 1 Tat upregulates interleukin-2
            secretion in activated T cells
  JOURNAL   J. Virol. 68 (7), 4177-4185 (1994)
   PUBMED   8207793
REFERENCE   108 (bases 1 to 1760)
  AUTHORS   Scala,G., Ruocco,M.R., Ambrosino,C., Mallardo,M., Giordano,V.,
            Baldassarre,F., Dragonetti,E., Quinto,I. and Venuta,S.
  TITLE     The expression of the interleukin 6 gene is induced by the human
            immunodeficiency virus 1 TAT protein
  JOURNAL   J. Exp. Med. 179 (3), 961-971 (1994)
   PUBMED   8113688
REFERENCE   109 (bases 1 to 1760)
  AUTHORS   Deloukas,P., Dauwerse,J.G., van Ommen,G.J. and van Loon,A.P.
  TITLE     The human NFKB3 gene encoding the p65 subunit of transcription
            factor NF-kappa B is located on chromosome 11q12
  JOURNAL   Genomics 19 (3), 592-594 (1994)
   PUBMED   8188306
REFERENCE   110 (bases 1 to 1760)
  AUTHORS   Lyle,R., Valleley,E.M., Sharpe,P.T. and Hewitt,J.E.
  TITLE     An alternatively spliced transcript, p65 delta 2, of the gene
            encoding the p65 subunit of the transcription factor NF-kappa B
  JOURNAL   Gene 138 (1-2), 265-266 (1994)
   PUBMED   7907305
REFERENCE   111 (bases 1 to 1760)
  AUTHORS   Deloukas,P. and van Loon,A.P.
  TITLE     Genomic organization of the gene encoding the p65 subunit of
            NF-kappa B: multiple variants of the p65 protein may be generated
            by alternative splicing
  JOURNAL   Hum. Mol. Genet. 2 (11), 1895-1900 (1993)
   PUBMED   8281153
REFERENCE   112 (bases 1 to 1760)
  AUTHORS   Jeang,K.T., Chun,R., Lin,N.H., Gatignol,A., Glabe,C.G. and Fan,H.
  TITLE     In vitro and in vivo binding of human immunodeficiency virus type 1
            Tat protein and Sp1 transcription factor
  JOURNAL   J. Virol. 67 (10), 6224-6233 (1993)
   PUBMED   7690421
REFERENCE   113 (bases 1 to 1760)
  AUTHORS   Mathew,S., Murty,V.V., Dalla-Favera,R. and Chaganti,R.S.
  TITLE     Chromosomal localization of genes encoding the transcription
            factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by
            fluorescence in situ hybridization
  JOURNAL   Oncogene 8 (1), 191-193 (1993)
   PUBMED   8423996
REFERENCE   114 (bases 1 to 1760)
  AUTHORS   Taylor,J.P., Pomerantz,R., Bagasra,O., Chowdhury,M., Rappaport,J.,
            Khalili,K. and Amini,S.
  TITLE     TAR-independent transactivation by Tat in cells derived from the
            CNS: a novel mechanism of HIV-1 gene regulation
  JOURNAL   EMBO J. 11 (9), 3395-3403 (1992)
   PUBMED   1505523
REFERENCE   115 (bases 1 to 1760)
  AUTHORS   Liu,J., Perkins,N.D., Schmid,R.M. and Nabel,G.J.
  TITLE     Specific NF-kappa B subunits act in concert with Tat to stimulate
            human immunodeficiency virus type 1 transcription
  JOURNAL   J. Virol. 66 (6), 3883-3887 (1992)
   PUBMED   1583734
REFERENCE   116 (bases 1 to 1760)
  AUTHORS   Ruben,S.M., Dillon,P.J., Schreck,R., Henkel,T., Chen,C.H.,
            Maher,M., Baeuerle,P.A. and Rosen,C.A.
  TITLE     Isolation of a rel-related human cDNA that potentially encodes the
            65-kD subunit of NF-kappa B
  JOURNAL   Science 251 (5000), 1490-1493 (1991)
   PUBMED   2006423
REFERENCE   117 (bases 1 to 1760)
  AUTHORS   Nolan,G.P., Ghosh,S., Liou,H.C., Tempst,P. and Baltimore,D.
  TITLE     DNA binding and I kappa B inhibition of the cloned p65 subunit of
            NF-kappa B, a rel-related polypeptide
  JOURNAL   Cell 64 (5), 961-969 (1991)
   PUBMED   2001591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M62399.1.
            On Apr 21, 2004 this sequence version replaced gi:11496238.
            
            Summary: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL
            (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex.
            The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of
            NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA,
            MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by
            trapping it in the cytoplasm. Phosphorylation of serine residues on
            the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM
            603258) marks them for destruction via the ubiquitination pathway,
            thereby allowing activation of the NFKB complex. Activated NFKB
            complex translocates into the nucleus and binds DNA at
            kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or
            5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G
            purine; and Y is a C or T pyrimidine).[supplied by OMIM].
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13"
     gene            1..1760
                     /gene="RELA"
                     /note="synonym: NFKB3"
                     /db_xref="GeneID:5970"
                     /db_xref="MIM:164014"
     CDS             73..1728
                     /gene="RELA"
                     /note="v-rel avian reticuloendotheliosis viral oncogene
                     homolog A (nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells 3 (p65));
                     go_component: nucleus [goid 0005634] [evidence TAS] [pmid
                     10747850];
                     go_component: transcription factor complex [goid 0005667]
                     [evidence TAS] [pmid 10935546];
                     go_function: protein binding [goid 0005515] [evidence IPI]
                     [pmid 14624448];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_function: signal transducer activity [goid 0004871]
                     [evidence IEP] [pmid 12761501];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence TAS] [pmid 10928981];
                     go_process: anti-apoptosis [goid 0006916] [evidence TAS]
                     [pmid 10747850];
                     go_process: response to toxin [goid 0009636] [evidence
                     TAS] [pmid 10747850];
                     go_process: transcription from Pol II promoter [goid
                     0006366] [evidence NR];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA];
                     go_process: positive regulation of I-kappaB
                     kinase/NF-kappaB cascade [goid 0043123] [evidence IEP]
                     [pmid 12761501]"
                     /codon_start=1
                     /product="v-rel reticuloendotheliosis viral oncogene
                     homolog A, nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells 3, p65"
                     /protein_id="NP_068810.2"
                     /db_xref="GI:46430499"
                     /db_xref="GeneID:5970"
                     /db_xref="MIM:164014"
                     /translation="MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAG
                     SIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEA
                     ELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLC
                     FQVTVRDPSGRPLRLPPVLPHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDK
                     VQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPS
                     DRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVP
                     SRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPA
                     PAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDL
                     GALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQ
                     RPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS"
ORIGIN      
        1 ggcgaatggc tcgtctgtag tgcacgccgc gggcccagct gcgaccccgg ccccgccccc
       61 gggaccccgg ccatggacga actgttcccc ctcatcttcc cggcagagcc agcccaggcc
      121 tctggcccct atgtggagat cattgagcag cccaagcagc ggggcatgcg cttccgctac
      181 aagtgcgagg ggcgctccgc gggcagcatc ccaggcgaga ggagcacaga taccaccaag
      241 acccacccca ccatcaagat caatggctac acaggaccag ggacagtgcg catctccctg
      301 gtcaccaagg accctcctca ccggcctcac ccccacgagc ttgtaggaaa ggactgccgg
      361 gatggcttct atgaggctga gctctgcccg gaccgctgca tccacagttt ccagaacctg
      421 ggaatccagt gtgtgaagaa gcgggacctg gagcaggcta tcagtcagcg catccagacc
      481 aacaacaacc ccttccaagt tcctatagaa gagcagcgtg gggactacga cctgaatgct
      541 gtgcggctct gcttccaggt gacagtgcgg gacccatcag gcaggcccct ccgcctgccg
      601 cctgtccttc ctcatcccat ctttgacaat cgtgccccca acactgccga gctcaagatc
      661 tgccgagtga accgaaactc tggcagctgc ctcggtgggg atgagatctt cctactgtgt
      721 gacaaggtgc agaaagagga cattgaggtg tatttcacgg gaccaggctg ggaggcccga
      781 ggctcctttt cgcaagctga tgtgcaccga caagtggcca ttgtgttccg gacccctccc
      841 tacgcagacc ccagcctgca ggctcctgtg cgtgtctcca tgcagctgcg gcggccttcc
      901 gaccgggagc tcagtgagcc catggaattc cagtacctgc cagatacaga cgatcgtcac
      961 cggattgagg agaaacgtaa aaggacatat gagaccttca agagcatcat gaagaagagt
     1021 cctttcagcg gacccaccga cccccggcct ccacctcgac gcattgctgt gccttcccgc
     1081 agctcagctt ctgtccccaa gccagcaccc cagccctatc cctttacgtc atccctgagc
     1141 accatcaact atgatgagtt tcccaccatg gtgtttcctt ctgggcagat cagccaggcc
     1201 tcggccttgg ccccggcccc tccccaagtc ctgccccagg ctccagcccc tgcccctgct
     1261 ccagccatgg tatcagctct ggcccaggcc ccagcccctg tcccagtcct agccccaggc
     1321 cctcctcagg ctgtggcccc acctgccccc aagcccaccc aggctgggga aggaacgctg
     1381 tcagaggccc tgctgcagct gcagtttgat gatgaagacc tgggggcctt gcttggcaac
     1441 agcacagacc cagctgtgtt cacagacctg gcatccgtcg acaactccga gtttcagcag
     1501 ctgctgaacc agggcatacc tgtggccccc cacacaactg agcccatgct gatggagtac
     1561 cctgaggcta taactcgcct agtgacaggg gcccagaggc cccccgaccc agctcctgct
     1621 ccactggggg ccccggggct ccccaatggc ctcctttcag gagatgaaga cttctcctcc
     1681 attgcggaca tggacttctc agccctgctg agtcagatca gctcctaagg gggtgacgcc
     1741 tgccctcccc agagcactgg
//

LOCUS       NM_022075               2352 bp    mRNA    linear   PRI 26-OCT-2004
DEFINITION  Homo sapiens LAG1 longevity assurance homolog 2 (S. cerevisiae)
            (LASS2), transcript variant 2, mRNA.
ACCESSION   NM_022075
VERSION     NM_022075.2  GI:32455257
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Pan,H., Qin,W.X., Huo,K.K., Wan,D.F., Yu,Y., Xu,Z.G., Hu,Q.D.,
            Gu,K.T., Zhou,X.M., Jiang,H.Q., Zhang,P.P., Huang,Y., Li,Y.Y. and
            Gu,J.R.
  TITLE     Cloning, mapping, and characterization of a human homologue of the
            yeast longevity assurance gene LAG1
  JOURNAL   Genomics 77 (1-2), 58-64 (2001)
   PUBMED   11543633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY091458.1 and BC001357.2.
            On Jul 7, 2003 this sequence version replaced gi:31077093.
            
            Summary: The protein encoded by this gene has sequence similarity
            to yeast longevity assurance gene-1 (Lag1). In yeast Lag1 is
            preferentially expressed in cells that have undergone a small
            number of cell divisions. Yeast lifespan can be increased or
            decreased by mutation or overexpression of this gene. The human
            protein may play a role in the regulation of cell growth.
            Alternative splicing occurs at this locus and three transcript
            variants encoding two distinct isoforms have been identified.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to transcript variant 1. Variants 1 and 2 encode the same isoform
            (1).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..2352
                     /gene="LASS2"
                     /note="synonyms: L3, SP260, TMSG1, MGC987, FLJ10243"
                     /db_xref="GeneID:29956"
                     /db_xref="MIM:606920"
     CDS             227..1369
                     /gene="LASS2"
                     /note="isoform 1 is encoded by transcript variant 2; tumor
                     metastasis-suppressor; L3 pigment; longevity assurance
                     (LAG1, S. cerevisiae) homolog 2;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_process: lipid biosynthesis [goid 0008610] [evidence
                     IEA];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="LAG1 longevity assurance homolog 2 isoform 1"
                     /protein_id="NP_071358.1"
                     /db_xref="GI:31077094"
                     /db_xref="GeneID:29956"
                     /db_xref="MIM:606920"
                     /translation="MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLP
                     LALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVEL
                     LSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWF
                     YDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATII
                     LISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITR
                     LVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGK
                     LVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND"
     polyA_signal    2238..2243
                     /gene="LASS2"
     polyA_site      2258
                     /gene="LASS2"
     polyA_signal    2308..2313
                     /gene="LASS2"
     polyA_site      2334
                     /gene="LASS2"
ORIGIN      
        1 tttttttccc ggctgggctc gggctcagct cgactgggct cggcgggcgg cggcggcggc
       61 gccggcggct ggcggaggag ggagggcgag ggcgggcgcg ggccggcggg cgggcggaag
      121 agggaggaga ggcgcgggga gccaggcctc ggggcctcgg agcaaccacc cgagcagacg
      181 gagtacacgg agcagcggcc ccggccccgc caacgctgcc gccgggatgc tccagacctt
      241 gtatgattac ttctggtggg aacgtctgtg gctgcctgtg aacttgacct gggccgatct
      301 agaagaccga gatggacgtg tctacgccaa agcctcagat ctctatatca cgctgcccct
      361 ggccttgctc ttcctcatcg ttcgatactt ctttgagctg tacgtggcta caccactggc
      421 tgccctcttg aacataaagg agaaaactcg gctgcgggca cctcccaacg ccaccttgga
      481 acatttctac ctgaccagtg gcaagcagcc caagcaggtg gaagtagagc ttttgtcccg
      541 gcagagcggg ctctctggcc gccaggtaga gcgttggttc cgtcgccgcc gcaaccagga
      601 ccggcccagt ctcctcaaga agttccgaga agccagctgg agattcacat tttacctgat
      661 tgccttcatt gccggcatgg ccgtcattgt ggataaaccc tggttctatg acatgaagaa
      721 agtttgggag ggatatccca tacagagcac tatcccttcc cagtattggt actacatgat
      781 tgaactttcc ttctactggt ccctgctctt cagcattgcc tctgatgtca agcgaaagga
      841 tttcaaggaa cagatcatcc accatgtggc caccatcatt ctcatcagct tttcctggtt
      901 tgccaattac atccgagctg ggactctaat catggctctg catgactctt ccgattacct
      961 gctggagtca gccaagatgt ttaactacgc gggatggaag aacacctgca acaacatctt
     1021 catcgtcttc gccattgttt ttatcatcac ccgactggtc atcctgccct tctggatcct
     1081 gcattgcacc ctggtgtacc cactggagct ctatcctgcc ttctttggct attacttctt
     1141 caattccatg atgggagttc tacagctgct gcatatcttc tgggcctacc tcattttgcg
     1201 catggcccac aagttcataa ctggaaagct ggtagaagat gaacgcagtg accgggaaga
     1261 aacagagagc tcagaggggg aggaggctgc agctggggga ggagcaaaga gccggcccct
     1321 agccaatggc caccccatcc tcaataacaa ccatcgtaag aatgactgaa ccattattcc
     1381 agctgcctcc cagattaatg cataaagcca aggaactacc ccgctccctg cgctataggg
     1441 tcactttaag ctctggggaa aaaggagaaa gtgagaggag agttctctgc atcctccctc
     1501 cttgcttgtc acccagttgc ctttaaacca aattctaacc agcctatccc caggtagggg
     1561 gacgttggtt atattctgtt agagggggac ggtcgtattt tcctccctac ccgccaagtc
     1621 atcctttcta ctgcttttga ggccctccct cagctctctg tgggtagggg ttacaattca
     1681 cattccttat tctgagaatt tggccccagc tgtttgcctt tgactccctg acctccagag
     1741 ccagggttgt gccttattgt cccatctgtg ggcctcattc tgccaaagct ggaccaaggc
     1801 taacctttct aagctcccta acttgggcca gaaaccaaag ctgagctttt aactttctcc
     1861 ctctatgaca caaatgaatt gagggtagga ggagggtgca cataaccctt accctacctc
     1921 tgccaaaaag tgggggctgt actggggact gctcggatga tctttcttag tgctacttct
     1981 ttcagctgtc cctgtagcga caggtctaag atctgactgc ctcctccttt ctctggcctc
     2041 ttcccccttc cctcttctct tcagctaggc tagctggttt ggagtagaat ggcaactaat
     2101 tctaattttt atttattaaa tatttggggt tttggtttta aagccagaat tacggctagc
     2161 acctagcatt tcagcagagg gaccatttta gaccaaaatg tactgttaat gggttttttt
     2221 ttaaaattaa aagattaaat aaaaaatatt aaataaaaca tggcaataag tgtcagacta
     2281 ttaggaattg agaaggggga tcaactaaat aaacgaagag agtctttctt aaaaaaaaaa
     2341 aaaaaaaaaa aa
//

LOCUS       NM_022152               2375 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens PP1201 protein (PP1201), mRNA.
ACCESSION   NM_022152
VERSION     NM_022152.4  GI:50593007
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from CD514853.1, BX471120.1,
            BC026693.2, CF994144.1, CA488388.1, AK093911.1, BC007980.2 and
            AF193045.1.
            On Jul 26, 2004 this sequence version replaced gi:34147460.
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.3-p24.1"
     gene            1..2375
                     /gene="PP1201"
                     /db_xref="GeneID:64114"
     CDS             133..1068
                     /gene="PP1201"
                     /codon_start=1
                     /product="PP1201 protein"
                     /protein_id="NP_071435.2"
                     /db_xref="GI:50593008"
                     /db_xref="GeneID:64114"
                     /translation="MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQ
                     PGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKV
                     YSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRR
                     FPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTS
                     CTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNR
                     KHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN"
ORIGIN      
        1 gggcgcggag ccccagccga gcctagccct gcccggcccc ggaggacttg caacactccg
       61 aggccaggaa cgctccgtct ggaacggcgc aggtcccagc agctggggtt ccccctcagc
      121 ccgtgagcag ccatgtccaa ccccagcgcc ccaccaccat atgaagaccg caaccccctg
      181 tacccaggcc ctccgccccc tgggggctat gggcagccat ctgtcctgcc aggagggtat
      241 cctgcctacc ctggctaccc gcagcctggc tacggtcacc ctgctggcta cccacagccc
      301 atgcccccca cccacccgat gcccatgaac tacggcccag gccatggcta tgatggggag
      361 gagagagcgg tgagtgatag cttcgggcct ggagagtggg atgaccggaa agtgcgacac
      421 acttttatcc gaaaggttta ctccatcatc tccgtgcagc tgctcatcac tgtggccatc
      481 attgctatct tcacctttgt ggaacctgtc agcgcctttg tgaggagaaa tgtggctgtc
      541 tactacgtgt cctatgctgt cttcgttgtc acctacctga tccttgcctg ctgccaggga
      601 cccagacgcc gtttcccatg gaacatcatt ctgctgaccc tttttacttt tgccatgggc
      661 ttcatgacgg gcaccatttc cagtatgtac caaaccaaag ccgtcatcat tgcaatgatc
      721 atcactgcgg tggtatccat ttcagtcacc atcttctgct ttcagaccaa ggtggacttc
      781 acctcgtgca caggcctctt ctgtgtcctg ggaattgtgc tcctggtgac tgggattgtc
      841 actagcattg tgctctactt ccaatacgtt tactggctcc acatgctcta tgctgctctg
      901 ggggccattt gtttcaccct gttcctggct tacgacacac agctggtcct ggggaaccgg
      961 aagcacacca tcagccccga ggactacatc actggcgccc tgcagattta cacagacatc
     1021 atctacatct tcacctttgt gctgcagctg atgggggatc gcaattaagg agcaagcccc
     1081 cattttcacc cgatcctggg ctctcccttc caagctagag ggctgggccc tatgactgtg
     1141 gtctgggctt taggcccctt tccttcccct tgagtaacat gcccagtttc ctttctgtcc
     1201 tggagacagg tggcctctct ggctatggat gtgtgggtac ttggtgggga cggaggagct
     1261 agggactaac tgttgctctt ggtgggcttg gcagggacta ggctgaagat gtgtcttctc
     1321 cccgccacct actgtatgac accacattct tcctaacagc tggggttgtg aggaatatga
     1381 aaagagccta ttcgatagct agaagggaat atgaaaggta gaagtgactt caaggtcacg
     1441 aggttcccct cccacctctg tcacaggctt cttgactacg tagttggagc tatttcttcc
     1501 cccagcaaag ccagagagct ttgtccccgg cctcctggac acataggcca ttatcctgta
     1561 ttcctttggc ttggcatctt ttagctcagg aaggtagaag agatctgtgc ccatgggtct
     1621 ccttgcttca atcccttctt gtttcagtga catatgtatt gtttatctgg gttagggatg
     1681 ggggacagat aatagaacga gcaaagtaac ctatacaggc cagcatggaa cagcatctcc
     1741 cctgggcttg ctcctggctt gtgacgctat aagacagagc aggccacatg tggccatctg
     1801 ctccccattc ttgaaagctg ctggggcctc cttgcaggct tctggatctc tggtcagagt
     1861 gaactcttgc ttcctgtatt caggcagctc agagcagaaa gtaaggggca gagtcatacg
     1921 tgtggccagg aagtagccag ggtgaagaga gactcggtgc gggcagggag aatgcctggg
     1981 ggtccctcac ctggctaggg agataccgaa gcctactgtg gtactgaaga cttctgggtt
     2041 ctttccttct gctaacccag ggagggtcct aagaggaagg tgacttctct ctgtttgtct
     2101 taagttgcac tgggggattt ctgacttgag gcccatctct ccagccagcc actgccttct
     2161 ttgtaatatt aagtgccttg agctggaatg gggaaggggg acaagggtca gtctgtcggg
     2221 tgggggcaga aatcaaatca gcccaaggat atagttagga ttaattactt aatagagaaa
     2281 tcctaactat atcacacaaa gggatacaac tataaatgta ataaagttta tgtctagaag
     2341 ttaaaaccca aaaaaaaaaa aaaaaaaaaa aaaaa
//

LOCUS       NM_022365               1881 bp    mRNA    linear   PRI 19-JAN-2005
DEFINITION  Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 1 (DNAJC1),
            mRNA.
ACCESSION   NM_022365
VERSION     NM_022365.2  GI:21361911
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Kroczynska,B., Evangelista,C.M., Samant,S.S., Elguindi,E.C. and
            Blond,S.Y.
  TITLE     The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human
            homologue interacts with alpha1-antichymotrypsin and kinetically
            interferes with its serpin inhibitory activity
  JOURNAL   J. Biol. Chem. 279 (12), 11432-11443 (2004)
   PUBMED   14668352
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK027263.1.
            On Jun 10, 2002 this sequence version replaced gi:11641286.
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..1881
                     /gene="DNAJC1"
                     /note="synonyms: HTJ1, ERdj1, DNAJL1"
                     /db_xref="GeneID:64215"
     CDS             108..1772
                     /gene="DNAJC1"
                     /note="DnaJ-like protein; DnaJ (Hsp40) homolog, subfamily
                     C, member 1 (DNAJC1)(DNAJL1);
                     go_component: nucleus [goid 0005634] [evidence ISS];
                     go_component: microsome [goid 0005792] [evidence ISS];
                     go_component: integral to membrane [goid 0016021]
                     [evidence ISS];
                     go_component: endoplasmic reticulum lumen [goid 0005788]
                     [evidence ISS];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: ribosome binding [goid 0043022] [evidence
                     ISS];
                     go_function: unfolded protein binding [goid 0051082]
                     [evidence IEA];
                     go_function: ATPase stimulator activity [goid 0001671]
                     [evidence TAS] [pmid 14668352];
                     go_function: Hsp70/Hsc70 protein regulator activity [goid
                     0030192] [evidence TAS] [pmid 14668352];
                     go_process: protein folding [goid 0006457] [evidence IEA];
                     go_process: regulation of protein secretion [goid 0050708]
                     [evidence IDA] [pmid 14668352];
                     go_process: negative regulation of proteolysis and
                     peptidolysis [goid 0045861] [evidence TAS] [pmid
                     14668352]"
                     /codon_start=1
                     /product="DnaJ (Hsp40) homolog, subfamily C, member 1"
                     /protein_id="NP_071760.2"
                     /db_xref="GI:21361912"
                     /db_xref="GeneID:64215"
                     /translation="MTAPCSQPAQLPGRRQLGLVPFPPPPPRTPLLWLLLLLLAAVAP
                     ARGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENA
                     ETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFI
                     ILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGSKSVDVSKLGASEKNERLLMKPQ
                     WHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQK
                     KVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEED
                     LSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKS
                     TVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARL
                     LEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELA
                     LQQYPRGSSDRWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAKS"
ORIGIN      
        1 gcgcttttca ctgacaggcg ctgttcccca cagccagcgc cgcccgccac gtcccagctc
       61 tcggccaacg gagctgcgcg gcgggtgacc tttccgagcc cagcgcgatg acggctcctt
      121 gctcccagcc ggcgcagctt cctggacgcc gccagctcgg gctggtgccg ttcccgccgc
      181 cgccgccgcg gacgccgctg ctgtggctgc tgctgctgct gctggccgcc gtggcgccgg
      241 cgcgcggctg ggagagcgga gacctggagt tgtttgactt agtggaggag gtgcagctca
      301 acttctacca gttcctcggg gtgcagcagg atgcatcatc tgcagacatc agaaaagcat
      361 atcgtaagct ttcactaact ttacatccag acaagaataa agatgaaaat gcagaaactc
      421 agtttagaca attggtggcc atttatgaag ttttaaagga tgatgaacga aggcagaggt
      481 atgatgatat tctgatcaat ggacttccag attggcgaca gcctgtattc tactacaggc
      541 gggtgagaaa aatgagcaat gctgagctgg cattactctt gttcattatt ctcacagtgg
      601 gtcattatgc tgtggtttgg tcaatctacc tggaaaaaca actggatgaa ctactaagta
      661 gaaaaaagag agaaaagaaa aaaaagactg gcagcaagag tgtggatgta tcaaaactcg
      721 gtgcttcaga aaaaaatgaa agattgctga tgaaaccaca gtggcatgat ttgcttccat
      781 gcaaactggg gatttggttt tgccttacac taaaagcatt acctcacctc atccaggatg
      841 ctgggcagtt ttatgctaaa tataaagaaa caagattgaa ggaaaaggaa gatgcactga
      901 ctagaactga acttgaaaca cttcaaaaac agaagaaagt taaaaaacca aaacctgaat
      961 ttcctgtata cacaccttta gaaactacat atattcagtc ttatgatcat ggaacttcca
     1021 tagaagaaat tgaggaacaa atggatgatt ggttggaaaa caggaaccga acacagaaaa
     1081 aacaggcacc tgaatggaca gaagaggacc tcagccaact gacaagaagt atggttaagt
     1141 tcccaggagg gactccaggt cgatgggaaa agattgccca cgaattgggt cgatctgtga
     1201 cagatgtgac aaccaaagcc aagcaactga aggattcagt gacctgctcc ccaggaatgg
     1261 ttagactctc cgaactcaaa tcgacagttc agaattccag gcccatcaaa acggccacca
     1321 ccttgcccga tgacatgatc acccagcgag aggacgcaga gggggtggca gcggaggagg
     1381 agcaggaggg agactccggt gagcaggaga ccggggccac tgatgcccgg cctcggaggc
     1441 ggaagccagc caggctgctg gaggctacag cgaagccgga gccagaggag aagtccagag
     1501 ccaagcggca gaaggacttt gacatagcag aacaaaacga gtccagcgac gaggagagcc
     1561 tgagaaaaga gagagctcgg tctgcagagg agccgtggac tcaaaatcaa cagaaacttc
     1621 tggaactggc gttgcagcag tacccaaggg gatcctctga ccgctgggac aaaatagcca
     1681 gatgtgtccc gtccaagagc aaggaagact gtatcgctag gtacaagttg ctggttgaac
     1741 tggtccaaaa gaaaaaacaa gctaaaagct gaatattctg ggagatgatg ttcaccttca
     1801 ttttccaaaa tgaatatctt aaaaatctta tgcagaaatt tgcattttgt acctcaatat
     1861 ttctacgtca tgtgccttag t
//

LOCUS       NM_022782               3624 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens M-phase phosphoprotein 9 (MPHOSPH9), mRNA.
ACCESSION   NM_022782
VERSION     NM_022782.2  GI:37537695
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol. Biol. Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from AK096541.1, AK091181.1,
            X98258.1, BU070541.1 and BX092492.1.
            On Oct 7, 2003 this sequence version replaced gi:13430861.
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3624
                     /gene="MPHOSPH9"
                     /note="synonyms: MPP9, MPP-9, FLJ12954, DKFZp434J034"
                     /db_xref="GeneID:10198"
                     /db_xref="MIM:605501"
     CDS             108..3203
                     /gene="MPHOSPH9"
                     /note="go_component: membrane [goid 0016020] [evidence
                     IEA];
                     go_component: Golgi apparatus [goid 0005794] [evidence
                     TAS] [pmid 8885239];
                     go_process: regulation of cell cycle [goid 0000074]
                     [evidence TAS] [pmid 8885239];
                     go_process: M phase of mitotic cell cycle [goid 0000087]
                     [evidence TAS] [pmid 8885239]"
                     /codon_start=1
                     /product="M-phase phosphoprotein 9"
                     /protein_id="NP_073619.2"
                     /db_xref="GI:37537696"
                     /db_xref="GeneID:10198"
                     /db_xref="MIM:605501"
                     /translation="MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVS
                     SGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPE
                     ECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVE
                     DGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLE
                     EKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERN
                     LTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSS
                     PSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITS
                     NDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEK
                     HARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSR
                     VRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQ
                     DLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDA
                     YTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIP
                     GAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSD
                     TPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLN
                     SASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSP
                     IRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPV
                     PNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKE
                     KDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSAN
                     L"
ORIGIN      
        1 atatacagga ggagataaaa aatttagtca aattacagac tagtagtgct tccttagctt
       61 cctgtgaagg aaattcttca aacaaacaag tatcttcgga aagtcaaatg ggtttttttt
      121 ctctaagcag tgagagaaat gaatctgtta tccattatcc tgaatccaca gaacctgaaa
      181 tacagcaaga aatgtccacg tcacaaccag actgcaatgt ggatagttgc tcagtaagca
      241 gtggatatgg caccttttgt atctcagaat taaatctgta caaatctaaa gaccctaagg
      301 agttcatgga gcacatagat gttcccaaag gacagtatgt agcacctgcg gtgccggctg
      361 agtcacttgt agatggtgtg aaaaatgaga atttttatat acagactcct gaagagtgtc
      421 atgtgtcttt aaaggaagat gtatccattt ctcctggtga atttgaacat aattttcttg
      481 gtgaaaataa ggtttctgaa gtatacagtg ggaaaacaaa tagtaatgct ataacatcat
      541 gggcacaaaa actgaagcag aaccaaccaa agagagcaca tgtagaagat ggaggttcaa
      601 gatctaaaca aggaaatgag caaagtaaga agacaccaat tgagaaatct gattttgctg
      661 ctgctacaca tcctcgtgct ttttacctca gtaaaccaga tgaaactcca aatgcttgga
      721 tgtctgattc aggaacagga ttgacttact ggaaactaga ggaaaaggat atgcaccact
      781 ctttgcctga aactttagag aagacgttca tatcattgtc ttccacagat gtgtcaccaa
      841 accagtctaa tactagtaat gagatgaagc taccgtcact gaaggatatt tattataaaa
      901 aacaaaggga aaacaagcag ttacctgaga ggaatctcac ttctgcttcc aacccaaatc
      961 atccaccaga ggtcctgact ctagatccta cgttacacat gaagccaaag cagcagattt
     1021 cagggattca acctcacggc cttccgaatg cccttgatga cagaatatcc ttttccccgg
     1081 actctgttct agagcctagt atgtctagtc cctctgacat agactcattt tcacaagcaa
     1141 gtaatgtcac ttctcagtta cctggatttc caaaatatcc ctcacacaca aaagcttctc
     1201 cggtggactc ttggaaaaat cagacattcc aaaacgaaag taggaccagt tccacgtttc
     1261 cgtcagtata taccattact agtaatgata tctcggtcaa cactgtagat gaagaaaaca
     1321 ctgtcatggt tgcttcggcc tcagtcagtc agtcccagct tccaggtaca gccaacagtg
     1381 tcccagaatg catttcattg acttccttgg aagatcctgt gatattgtct aagattaggc
     1441 agaatctgaa ggaaaagcat gctcgacaca tagcagatct tcgagcttat tatgaatcag
     1501 aaataaatag tttgaaacag aagctggagg caaaagaaat ctctggagtt gaagattgga
     1561 agataaccaa tcaaattctt gtagacagat gtggccaatt agatagtgct ttgcatgaag
     1621 ctactagtcg cgtgagaaca cttgaaaata agaataactt actggaaatt gaagtgaatg
     1681 atttgagaga acgcttcagt gcagccagca gtgcttccaa aattttgcag gaacgaattg
     1741 aagaaatgag aacaagcagt aaagaaaaag acaataccat cattcgacta aaatctagac
     1801 tgcaagattt agaagaagca tttgagaatg cttacaaact ctcagatgat aaagaagctc
     1861 aactaaaaca agagaacaaa atgtttcaag atcttttagg agagtatgag tcccttggaa
     1921 aagaacacag gagagtaaag gatgcattaa atacaactga gaacaaattg cttgatgcat
     1981 atactcagat ttctgatttg aaaagaatga tttcaaaact tgaagctcag gtcaagcaag
     2041 tagaacatga aaatatgtta agccttcgtc ataattctag aattcacgtg agaccctcgc
     2101 gtgccaacac actagcaact tcagacgtca gcaggcggaa atggctgatt ccaggtgcag
     2161 agtattccat ctttactggc cagcctctgg acacccagga cagtaacgtg gataaccagc
     2221 tggaggaaac ctgtagccta gggcaccgtt cacctctgga aaaggattct tcacctggaa
     2281 gttcatcaac aagcttgttg ataaaaaagc aaagagagac ttcagacacg ccgatcatga
     2341 gagctttaaa agaacttgat gagggaaaaa tatttaaaaa ttgggggaca cagacagaga
     2401 aagaggacac ctcaaatata aatcctcggc aaactgaaac ttcagttaat gcaagtcgtt
     2461 ctccagaaaa gtgtgcccaa cagagacaaa agagacttaa ttcggcctca cagagatcat
     2521 catctttacc accttcaaat cgtaaatcaa gtactccaac aaaaagagag attatgctaa
     2581 caccagtgac tgtggcttat agtccaaagc gatcccctaa agaaaacttg tccccaggat
     2641 ttagtcatct gcttagcaaa aatgagagca gtccaattcg atttgatata cttttggatg
     2701 atttagatac tgttcctgtg tctacattac aacgtaccaa tccaagaaag caactccagt
     2761 ttcttcctct agatgactcg gaagaaaaaa cttattctga gaaagccacc gataaccatg
     2821 ttaatcatag ctcttgccct gaaccggtgc caaatggagt gaagaaagta tctgtgagaa
     2881 cagcctggga gaagaataaa tcagttagct acgaacagtg taagccggtt tcagtcactc
     2941 cacaggggaa tgattttgaa tatacagcaa aaattcggac cctagctgaa acagaacgat
     3001 tttttgatga acttacaaaa gaaaaggacc agattgaggc agcactaagc aggatgcctt
     3061 ctcctggagg acgaatcact ttacagacaa gattaaatca ggaagccttg gaagatcgtt
     3121 tggaaaggat taatcgagaa ctgggttcag ttcgcatgac gctaaagaaa ttccatgttt
     3181 tgcgcacctc tgcaaatctt tgagatttgt agccattaaa ttttgagaca tttttgtttg
     3241 cactaatgta taattatgca gtcagaaaag gcaaactatt ttgtactgtt tataagcctt
     3301 caaacagtag ttttacaatc atgctattct tacacttgct attttatact tcaaatggcc
     3361 acatattttc aagatatttt tgttatgctc aggaatctct tgtatatttt actatttaaa
     3421 aagcattatt tttaaatagt atctgtctcc aatttatatc aagaataagg aaatataaac
     3481 agaggaagca gcttgtttct aaacaaatag tgttatcctt ttacaattaa ctgcacatca
     3541 attttataga cttgttctac attgtaaata caattcagtt tttaaaaaat aaagcttaat
     3601 agcttccata aaaaaaaaaa aaaa
//

LOCUS       NM_022821               1501 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens elongation of very long chain fatty acids (FEN1/Elo2,
            SUR4/Elo3, yeast)-like 1 (ELOVL1), mRNA.
ACCESSION   NM_022821 NM_016031
VERSION     NM_022821.2  GI:42490763
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BU786323.1, AF151846.1,
            BC000618.2 and BU180063.1.
            On Feb 9, 2004 this sequence version replaced gi:13489092.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1501
                     /gene="ELOVL1"
                     /note="synonyms: Ssc1, CGI-88"
                     /db_xref="GeneID:64834"
     CDS             129..968
                     /gene="ELOVL1"
                     /note="go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_component: endoplasmic reticulum [goid 0005783]
                     [evidence IEA];
                     go_process: fatty acid biosynthesis [goid 0006633]
                     [evidence IEA]"
                     /codon_start=1
                     /product="elongation of very long chain fatty acids
                     (FEN1/Elo2, SUR4/Elo3, yeast)-like 1"
                     /protein_id="NP_073732.1"
                     /db_xref="GI:13489093"
                     /db_xref="GeneID:64834"
                     /translation="MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLS
                     LGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSP
                     EALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAP
                     GGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQ
                     YYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKV
                     KAN"
     polyA_signal    1461..1466
                     /gene="ELOVL1"
     polyA_site      1480
                     /gene="ELOVL1"
                     /evidence=experimental
     polyA_site      1483
                     /gene="ELOVL1"
                     /evidence=experimental
ORIGIN      
        1 cagaaagtcg gcccagcaga tgaggaagtg gcaggcaggc aggctggccc cggggacttc
       61 tctctggccc tgctccctcc gagcgctccg ccgttgcccg cctggcccct acggagtcct
      121 tagccaggat ggaggctgtt gtgaacttgt accaagaggt gatgaagcac gcagatcccc
      181 ggatccaggg ctaccctctg atggggtccc ccttgctaat gacctccatt ctcctgacct
      241 acgtgtactt cgttctctca cttgggcctc gcatcatggc taatcggaag cccttccagc
      301 tccgtggctt catgattgtc tacaacttct cactggtggc actctccctc tacattgtct
      361 atgagttcct gatgtcgggc tggctgagca cctatacctg gcgctgtgac cctgtggact
      421 attccaacag ccctgaggca cttaggatgg ttcgggtggc ctggctcttc ctcttctcca
      481 agttcattga gctgatggac acagtgatct ttattctccg aaagaaagac gggcaggtga
      541 ccttcctaca tgtcttccat cactctgtgc ttccctggag ctggtggtgg ggggtaaaga
      601 ttgccccggg aggaatgggc tctttccatg ccatgataaa ctcttccgtg catgtcataa
      661 tgtacctgta ctacggatta tctgcctttg gccctgtggc acaaccctac ctttggtgga
      721 aaaagcacat gacagccatt cagctgatcc agtttgtcct ggtctcactg cacatctccc
      781 agtactactt tatgtccagc tgtaactacc agtacccagt cattattcac ctcatctgga
      841 tgtatggcac catcttcttc atgctgttct ccaacttctg gtatcactct tataccaagg
      901 gcaagcggct gccccgtgca cttcagcaaa atggagctcc aggtattgcc aaggtcaagg
      961 ccaactgaga agcatggcct agataggcgc ccacctaagt gcctcaggac tgcaccttag
     1021 ggcagtgtcc gtcagtgccc tctccaccta cacctgtgac caaggcttat gtggtcagga
     1081 ctgagcaggg gactggccct cccctcccca cagctgctct acagggacca cggctttggt
     1141 tcctcaccca cttcccccgg gcagctccag ggatgtggcc tcattgctgt ctgccactcc
     1201 agagctgggg gctaaaaggg ctgtacagtt atttccccct ccctgcctta aaacttggga
     1261 gaggagcact cagggctggc cccacaaagg gtctcgtggc ctttttcctc acacagaaga
     1321 ggtcagcaat aatgtcactg tggacccagt ctcactcctc caccccacac actgaagcag
     1381 tagcttctgg gccaaaggtc agggtgggcg ggggcctggg aatacagcct gtggaggctg
     1441 cttactcaac ttgtgtctta attaaaagtg acagaggaaa ccaaaaaaaa aaaaaaaaaa
     1501 a
//

LOCUS       NM_022833               4007 bp    mRNA    linear   PRI 16-DEC-2004
DEFINITION  Homo sapiens chromosome 9 open reading frame 88 (C9orf88), mRNA.
ACCESSION   NM_022833 XM_497077
VERSION     NM_022833.2  GI:51093862
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BM557756.1, BX280720.1 and
            AL137555.1.
            On or before Aug 30, 2004 this sequence version replaced
            gi:51467624, gi:24308286.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..4007
                     /gene="C9orf88"
                     /note="synonyms: MEG-3, FLJ13518, FLJ22151, FLJ22298,
                     bA356B19.6, DKFZP434H0820"
                     /db_xref="GeneID:64855"
     CDS             203..2443
                     /gene="C9orf88"
                     /note="Niban-like protein; RP11-356B19.6"
                     /codon_start=1
                     /product="chromosome 9 open reading frame 88"
                     /protein_id="NP_073744.2"
                     /db_xref="GI:51093863"
                     /db_xref="GeneID:64855"
                     /translation="MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSM
                     RHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYE
                     NKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPL
                     ILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQ
                     SKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVY
                     HMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVC
                     VRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKL
                     SRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFET
                     LLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKL
                     APTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYR
                     DSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVS
                     VVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESP
                     QPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSA
                     GVQTEF"
     polyA_signal    3927..3932
                     /gene="C9orf88"
     polyA_site      3949
                     /gene="C9orf88"
ORIGIN      
        1 gccaaggcgg ccggctggag ggacggggcc cgaccgggag cggagccgga gcggaagccg
       61 cagccgggcg gcgggagcgg cgggagcggc gggagcgggg gaagcagggc gggccgggct
      121 ccatggcgcc agcggcgtcc gcctgagcag cgcgggcaac agcggcggcg tcggccggat
      181 cgggccgcga cacctcctgg ccatggggga cgtgctgtcc acgcacctgg acgacgcccg
      241 gcgccagcac atcgcagaaa aaaccgggaa gatcctgacg gagttcctcc agttctatga
      301 agaccagtat ggcgtggctc tcttcaacag catgcgccat gagattgagg gcacggggct
      361 gccgcaggcc cagctgctct ggcgcaaggt gccactggac gagcgcatcg tcttctcggg
      421 gaacctcttc cagcaccagg aggacagcaa gaagtggaga aaccgcttca gcctcgtgcc
      481 ccacaactac gggctggtgc tctacgaaaa caaagcggcc tatgagcggc aggtcccacc
      541 acgagccgtc atcaacagtg caggctacaa aatcctcacg tccgtggacc aatacctgga
      601 gctcattggc aactccttac cagggaccac ggcaaagtcg ggcagtgccc ccatcctcaa
      661 gtgccccaca cagttcccgc tcatcctctg gcatccttat gcgcgtcact actacttctg
      721 catgatgaca gaagccgagc aggacaagtg gcaggctgtg ctgcaggact gcatccggca
      781 ctgcaacaat ggaatccctg aggactccaa ggtagagggc cctgcgttca cagatgccat
      841 ccgcatgtac cgacagtcca aggagctgta cggcacctgg gagatgctgt gtgggaacga
      901 ggtgcagatc ctgagcaacc tggtgatgga ggagctgggc cctgagctga aggcagagct
      961 cggcccgcgg ctgaagggga aaccgcagga gcggcagcgg cagtggatcc agatctcgga
     1021 cgccgtgtac cacatggtgt acgagcaggc caaggcgcgc ttcgaggagg tgctgtccaa
     1081 ggtgcagcag gtgcagccgg ccatgcaggc cgtcatccga actgacatgg accaaattat
     1141 cacctccaag gagcaccttg ccagcaagat ccgagccttc atcctcccca aggcagaggt
     1201 gtgcgtgcgg aaccatgtcc agccctacat cccatccatc ctggaggccc tgatggtccc
     1261 caccagccag ggcttcactg aggtgcgaga tgtcttcttc aaggaggtca cggacatgaa
     1321 cctgaacgtc atcaacgagg gcggcattga caagctgggc gagtacatgg agaagctgtc
     1381 ccggctggcg taccaccccc tgaagatgca gagctgctat gagaagatgg agtcgctgcg
     1441 actggacggg ctgcagcagc gatttgatgt gtccagcacg tccgtgttca agcagcgagc
     1501 ccagatccac atgcgggagc aaatggacaa tgccgtgtat acgttcgaga ccctcctgca
     1561 ccaggagctg gggaaggggc ccaccaagga ggagctgtgc aagtccatcc agcgggtcct
     1621 ggagcgggtg ctgaagaaat acgactacga cagcagctct gtgcggaaga ggttcttccg
     1681 ggaggcgctg ctgcagatca gcatcccgtt cctgctcaag aagctggccc ctacctgcaa
     1741 gtcggagctg ccccggttcc aggagctgat cttcgaggac tttgccaggt tcatcctggt
     1801 ggaaaacacg tacgaggagg tggtgctgca gaccgtcatg aaggacatcc tgcaggctgt
     1861 gaaggaggcc gcggtgcaga ggaagcacaa cctctaccgg gacagcatgg tcatgcacaa
     1921 cagcgacccc aacctgcacc tgctggccga gggcgccccc atcgactggg gcgaggagta
     1981 cagcaacagc ggcgggggcg gcagccccag ccccagcacc ccggagtcag ccaccctctc
     2041 ggaaaagcga cggcgcgcca agcaggtggt ctctgtggtc caggatgagg aggtggggct
     2101 gccctttgag gctagccctg agtcaccacc acctgcgtcc ccggacggtg tcactgagat
     2161 ccgaggcctg ctggcccaag gtctgcggcc tgagagcccc ccaccagccg gccccctgct
     2221 caacggggcc cccgctgggg agagtcccca gcctaaggcc gcccccgagg cctcctcgcc
     2281 gcctgcctca cccctccagc atctcctgcc tggaaaggct gtggaccttg ggccccccaa
     2341 gcccagcgac caggagactg gagagcaggt gtccagcccc agcagccacc ccgccctcca
     2401 caccaccacc gaggacagtg caggggtgca gactgagttc taggccagtg ggtccctgac
     2461 tgctgcacat ggcacaggcc gttcccttcc ggacccaggc aggctcagct ctggggaggg
     2521 caccctggtc tgtgccttgt gggtggaggc ggggcagggc tgtgtggcac cgccagggag
     2581 cgggcccacc tgagtcactt tattgggttc agtcaacact ttcttgctcc ctgttttctc
     2641 ttctgtggga tgatctcaga tgcaggggct ggttttgggg ttttcctgct tgtgccaagg
     2701 gctggacact gctggggggc tggaaagccc ctcccttcct gtccttctgt ggcctccatc
     2761 ccctcatggg tgctgccatc cttcctggag agagggaggt gaaagctggt gtgagcccag
     2821 tgggttcccg cccactcacc caggagctgg ctgggccagg accgggagag ggagcactgc
     2881 tgccctcctg gccctgctcc ttccgcagtt aggggtggac cgagcctcgc tttccccact
     2941 gttctggagg gaaggggaag gagggggtct tcaggctgga gccaggctgg gggtgctggg
     3001 tggagagatg agatttaggg ggtgcctcat ggggtgggca ggcctggggt gaaatgagaa
     3061 aggcccagaa cgtgcaggtc tgcggagggg aagtgtcctg agtgaaggag gggaccccca
     3121 tcctggggga tgctgggagt gagtgagtga gatggctgag tgagggttat ggggagcctg
     3181 aggttttatg ggcctgtgta tccccttctc ccggccccag cctgcctccc tcctgcccgc
     3241 ctggcccaca ggtctccctc tggtccctgt ccctctggtg gttggggatg gagcggcagc
     3301 aaggggtgta atggggctgg gttctgtctt ctacaggcca ccccgaggtc ctcagtggtt
     3361 gcctggggag ccggacgggg ctcctgaggg gtacaggttg ggtgggccct ccctgagggt
     3421 ctggggtcag gctttggcct ctgctgcctc tcagtcacca agtcacctcc ctctgaaaat
     3481 ccagtccctt ctttggatgt ccttgtgagt cactctgggc ctggctgtcg tccctcctca
     3541 gcttcttgtt cctgggacaa gggtcaagcc aggatgggcc caggcctggg atcccccacc
     3601 ccaggacccc caggccccct cccctgctgc tttgcggggg gcagggcaga aatggactcc
     3661 ttttgggtcc ccgaggtggg gtcccctccc agccctgcat cctccgtgcc ctagacctgc
     3721 tccccagagg aggggccttg acccacagga cgtgtggtgg cgcctggcac tcagggaccc
     3781 ccagctgccg cagccctggt ctctggcgca tctcttccct cttgtcccga agatctgcgc
     3841 ctctagtgcc ttttgagggg ttcccatcat ccctccctga tattgtattg aaaatattat
     3901 gcacactgtt catgcttcta ctaatcaata aacgctttat ttaaagccaa aaaaaaaaaa
     3961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//

LOCUS       NM_022899               3525 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens ARP8 actin-related protein 8 homolog (yeast) (ACTR8),
            mRNA.
ACCESSION   NM_022899
VERSION     NM_022899.3  GI:39812114
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3525)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BU070174.1, AK022996.1,
            AK026232.1 and BX354684.2.
            On Dec 12, 2003 this sequence version replaced gi:33636759.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3525
                     /gene="ACTR8"
                     /note="synonyms: ARP8, FLJ12934, FLJ22579"
                     /db_xref="GeneID:93973"
     CDS             60..1934
                     /gene="ACTR8"
                     /note="ARP8 (actin-related protein 8, yeast) homolog;
                     go_component: actin cytoskeleton [goid 0015629] [evidence
                     IEA];
                     go_function: structural constituent of cytoskeleton [goid
                     0005200] [evidence IEA]"
                     /codon_start=1
                     /product="actin-related protein 8"
                     /protein_id="NP_075050.3"
                     /db_xref="GI:39812115"
                     /db_xref="GeneID:93973"
                     /translation="MTQAEKGDTENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQ
                     SNFIIVIHPGSTTLRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPES
                     NEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTS
                     HHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQK
                     YLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGL
                     SSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQL
                     TNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMAL
                     FYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIG
                     FEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKA
                     LGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRI
                     IENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW
                     "
     polyA_site      2002
                     /gene="ACTR8"
                     /evidence=experimental
     polyA_site      2067
                     /gene="ACTR8"
                     /evidence=experimental
     polyA_signal    2135..2140
                     /gene="ACTR8"
     polyA_site      2157
                     /gene="ACTR8"
                     /evidence=experimental
     polyA_site      2165
                     /gene="ACTR8"
                     /evidence=experimental
ORIGIN      
        1 atcccggcag tcgtggctgc agcgctgagg cgagaggttg gtgggtgtct ccggccataa
       61 tgacccaggc tgagaagggt gatacggaga acggaaagga gaagggcggc gagaaggaga
      121 aggagcagcg cggcgtgaag cggcccatcg tgcccgcgct ggtgccggag tcgctgcaag
      181 agcaaatcca gagcaacttc atcattgtca tacatccagg ttcaacaact ttaaggattg
      241 gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac
      301 aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag
      361 aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa
      421 agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata
      481 agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc
      541 atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca
      601 atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc
      661 ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg
      721 aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata
      781 ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga
      841 ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta
      901 ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc
      961 ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc
     1021 taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc
     1081 ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc
     1141 aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat
     1201 taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg
     1261 ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg
     1321 atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg
     1381 accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg
     1441 atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc
     1501 tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca
     1561 tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact
     1621 gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg
     1681 gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac
     1741 catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc
     1801 cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac
     1861 tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg
     1921 cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg
     1981 tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc
     2041 atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa
     2101 actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt
     2161 gtaaactctc ttgccctctc tcagggtctc ataaactccc cagtgatgta aacgttgcta
     2221 ttgaaggttc tcatgtggtg aagcccttca tttaagttgg cttgaatctc atcagcaggc
     2281 agcctcatgc aaccatgagg gatagtatgt gacgagggag aactgtccac tcatgccatt
     2341 ttctctcttg tctagtattt cattaggatc taaagttgtc tgagttaaat gcacttatgt
     2401 gactcatgtg tcctcttaga atcccaaata gggggaaaaa gttttggtgg tttttgtttt
     2461 ttttttcatt ttctgttgga ttacagaaaa agaatgggac ccattcaggt ctcgatttcc
     2521 aaaggtaaag atggaaggct gggcagactg gcttttgtta cctgacatgc cgtagggtga
     2581 gcttagagga agaaagaaaa caatttttat ttggccaaaa cagaacaaat gctgaaaagg
     2641 aaatcttgtt tttttcctaa agccaaatag aaatgatttg ggtataattt aagagtcctt
     2701 gtgttgtaca gatatggtga ctgatgtagt tattaatact accaacttag tcatcaagcc
     2761 tcaattttcc tttacctgaa ggattaagtg aaagcttttg gagttcatga tgttcagtat
     2821 gatcagttaa ccttaacctc tgagcatcct gaagcaaaat ctaaataatg cagctattac
     2881 cactggtggt ccaggctctg gtgaagccct ctgagcccag gaggaagaga aagcattgtc
     2941 cagaggtagg aacacagtct gggagcccag agctctggga ggagtgggaa aatgctgctt
     3001 cctgctgctt gcttctaggc acctgcttcc gccatctcac ttaccatggc tagagatggg
     3061 ggtgagactg gggaaggaca aaagcaggga acagataagg gatggaaatc agaagggaat
     3121 atagaaagaa ctctggatgt ggagaaatgc cggtacctga gcattttgta tcaatgggag
     3181 taccctctgt aactgctcag taggttacaa atgaagagtc caccagtatt agaaacaatt
     3241 taaacttgcc agtaccaact gggatgtgtg ccttcaattt gaaaattgta tgttttattt
     3301 tttaaatttg ttaacagcat taatttatag agtattgatg tcatttatgt ttctgaggtg
     3361 tttcaacaca attttggatc agctgcctgt ttgcaaaaac ataatatatt tctgttaaac
     3421 agttcttcac ctaacagcat attgctctta taactggtag agctgtttca aaggaagttg
     3481 gtttctggtc caagttttga cctaaaccat gtccatcttc tatta
//

LOCUS       NM_024092               2097 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens hypothetical protein MGC5508 (MGC5508), mRNA.
ACCESSION   NM_024092
VERSION     NM_024092.1  GI:13129091
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Yu,W., Andersson,B., Worley,K.C., Muzny,D.M., Ding,Y., Liu,W.,
            Ricafrente,J.Y., Wentland,M.A., Lennon,G. and Gibbs,R.A.
  TITLE     Large-scale concatenation cDNA sequencing
  JOURNAL   Genome Res. 7 (4), 353-358 (1997)
   PUBMED   9110174
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Andersson,B., Wentland,M.A., Ricafrente,J.Y., Liu,W. and Gibbs,R.A.
  TITLE     A 'double adaptor' method for improved shotgun library construction
  JOURNAL   Anal. Biochem. 236 (1), 107-113 (1996)
   PUBMED   8619474
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC001309.1.
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2097
                     /gene="MGC5508"
                     /db_xref="GeneID:79073"
     CDS             73..804
                     /gene="MGC5508"
                     /codon_start=1
                     /product="hypothetical protein MGC5508"
                     /protein_id="NP_076997.1"
                     /db_xref="GI:13129092"
                     /db_xref="GeneID:79073"
                     /translation="MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQ
                     QKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGI
                     AAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRIL
                     WGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRG
                     LERQVEELRWRQRRAAKGARSVEEE"
ORIGIN      
        1 ggcgcgggtt tggtggcgcg tttcagcgaa gtcgcacgtg aaggatagca gtggcctgag
       61 aaagacccag tcatggcagc ctccagcatc agttcaccat ggggaaagca tgtgttcaaa
      121 gccattctga tggtcctagt ggcccttatc ctcctccact cagcattggc ccagtcccgt
      181 cgagactttg caccaccagg ccaacagaag agagaagccc cagttgatgt cttgacccag
      241 ataggtcgat ctgtgcgagg gacactggat gcctggattg ggccagagac catgcacctg
      301 gtgtcagagt cttcgtccca agtgttgtgg gccatctcat cagccatttc tgtggccttc
      361 tttgctctgt ctgggatcgc cgcacagctg ctgaatgcct tgggactagc tggtgattac
      421 ctcgcccagg gcctgaagct cagccctggc caggtccaga ccttcctgct gtggggagca
      481 ggggccctgg tcgtctactg gctgctgtct ctgctcctcg gcttggtctt ggccttgctg
      541 gggcggatcc tgtggggcct gaagcttgtc atcttcctgg ccggcttcgt ggccctgatg
      601 aggtcggtgc ctgacccttc cacccgggcc ctgctactcc tggccttgct gatcctctac
      661 gccctgctga gccggctcac tggctcccga gcctctgggg cccaactcga ggccaaggtg
      721 cgagggctgg aacgccaggt ggaggagctg cgctggcgcc agaggcgagc ggccaagggg
      781 gcccgcagtg tggaggagga gtgagccgga tgccccacac accgccagtg tcataccaaa
      841 gagctgagct gcttcggggc catgcagccc tcctgccagc cccctgccct tttcttgccc
      901 tgtctctgaa ccttcagaac attgatcctt gccgcagccc cactagccaa gagaaacaga
      961 gaaagaccat tccccctgcc tgtccttgcg gccctgtctt ctgaggttct ctgtctgggg
     1021 ttggctctct taaccctttc tctgctccca gcctgcctca ccagggaagg ttggaggggc
     1081 ctccctctgg cttctgcatc tgcgccagca aacatcactg ccgttggtct ctcatgactt
     1141 aactggcttc cctctgctgc tgccttggct tcctcctaat gctcgtgctc tcctgtcctt
     1201 ctgaagttgc tccttggcca aatctccagc tcccttcttg ttttcctcat cctcctaccc
     1261 tgtactccca ccaaaccatg gtcctttaag gcacgctcct gtcctcctca ttgcccagca
     1321 gtagggaggg gcaggggtaa ggggacctga ggataaaggg tggggaaaca gggtcccctg
     1381 aggcctgtgg gggctgcagg ggaggaggat gtaccttgtg tctctttcaa gtgccttaat
     1441 ccgagccagc agggccttct gcttgcctgc tgccatactg tatgtaggaa agtgttctgt
     1501 ggctgctttg tgtcaaaaga gcagtcactc tcagaatctt gattccccat cagccaaagc
     1561 aaaagatggc tgctgctttg taggcatgtg cctgcaagtg ggaccttgct gggcattata
     1621 tgccctgtgg gggtttcaga gaccctgaaa gaggagggag gacccgcctc cttgtctgca
     1681 caactgcatg cacttctctc cccatcgctc cacaacctga aaccgagaag gagttgctga
     1741 ccagtgccca ccccggcagc ccgggaggaa cacaggcagc tcctttccct tcacgtggtc
     1801 tgcagagagc agggtgagct gccagctgcc cctctccacc agggtaccct gtcttggtgg
     1861 ttaggggcca cttttccttt gaggctctag tggaggtgga tgtccttctc tgccaggctt
     1921 ggcacatgat gtgaagaata aatgcccaat tcttactgtt caggtttgat gtggaatcac
     1981 agctgcagtg atatatattt tttatcagtg cttggttggt tttaaataaa gtgcacgcta
     2041 ttttattatc ttgttctgaa taaaatgtat ttactccaaa aaaaaaaaaa aaaaaaa
//

LOCUS       NM_024774               5052 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens hypothetical protein FLJ21924 (FLJ21924), mRNA.
ACCESSION   NM_024774
VERSION     NM_024774.2  GI:40254966
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5052)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK126023.1.
            On Dec 20, 2003 this sequence version replaced gi:13376124.
FEATURES             Location/Qualifiers
     source          1..5052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..5052
                     /gene="FLJ21924"
                     /db_xref="GeneID:79832"
     CDS             357..4304
                     /gene="FLJ21924"
                     /codon_start=1
                     /product="hypothetical protein FLJ21924"
                     /protein_id="NP_079050.2"
                     /db_xref="GI:40254967"
                     /db_xref="GeneID:79832"
                     /translation="MNFLSTAESRTAQAAASGTTLLPQFRAPSWQTGMHSSAATELFA
                     TGPLPSTGTLPPSLSAYQHPTTFSNRNFATTSPLVLQDSTFNTTSNGILSHHDPLLQI
                     KTSQGTVPTALAFERLGSSVLSNSIPPQSSTYRSAQESAPHLLQPQFSLLPSALGGSQ
                     QTPQAYSSTLFTSSTASIERALLRECSVIKHHQRPSGTQSIQAQLTGSQHSLHSYLSN
                     SSVVNFQETTRQSSLSCSPIGDSTQNLPDSSPTQNYISMHSSQNVQTQESSSPQSQKF
                     LPAVQSSSFASSTHCQTLQNNITSPDPKSYAERKLDSDVYPSSKQEDGFPMQELQVLQ
                     PQASLESSTQRLSDGEINAQESTYKVSKADDRYSQSVIRSNSRLEDQVIGVALQASKK
                     EESVVGSVTQLNQQIGQVNNAATLDLKNSTNLIQTPQIRLNTKDLKQQHPLILKVHES
                     KVQEQHDQIINASSQIQIPNHALGHGHQASLPNTQVLLDSACDLQILQQSILQAGLGQ
                     VKASLQAQRVQSPQQIVHPFLQMEGHVIQSNGDHSQQQLHPQNSEVMKMDLSESSKPL
                     QQHLTTKGHFSETNQHDSKNQFVSLGSMCFPEAVLLSDERNILSNVDDILAATAAACG
                     VTPTDFSKSTSNETMQAVEDGDSKSHFQQSLDVRHVTSDFNSMTATVGKPQNINDTSL
                     NGNQVTVNLSPVPALQSKMTLDQQHIETPGQNIPTKVTSAVVGPSHEVQEQSSGPFKK
                     QSATNLESEEDSEAPVDSTLNNNRNQEFVSSSRSISGESATSESEFTLGGDDSGVSMN
                     PARSALALLAMAQSGDAVSVKIEEENQDLMHFNLQKKRAKGKGQVKEEDNSNQKQLKR
                     PAQGKRQNPRGTDIYLPYTPPSSESCHDGYQHQEKMRQKIKEVEEKQPEVKTGFIASF
                     LDFLKSGPKQQFSTLAVRMPNRTRRPGTQMVRTFCPPPLPKPSSTTPTPLVSETGGNS
                     PSDKVDNELKNLEHLSSFSSDEDDPGYSQDAYKSVSTPLTTLDATSDKKKKTEALQVA
                     TTSPTANTTGTATTSSTTVGAVKQEPLHSTSYAVNILENISSSESSKPIELDGLPSDQ
                     FAKGQDTVAIEGFTDEEDTESGGEGQYRERDEFVVKIEDIETFKEALKTGKEPPAIWK
                     VQKALLQKFVPEIRDGQREFAATNSYLGYFGDAKSKYKRIYVKFIENANKKEYVRVCS
                     KKPRNKPSQTIRTVQAKPSSSSKTSDPLASKTTTTKAPSVKPKVKQPKVKAEPPPKKR
                     KKWKEEFSSSQSDSSPEIHTSSSDDEEFEPPAPFVTRFLNTRAMKETFKSYME"
ORIGIN      
        1 agtcccagct acttgggagg ctgaggcagg aggattgctt gagcccagga gttggaggct
       61 acaataagct atgatccagc tgctgcactc tagcttgggt gacagagacc ctgtcttctt
      121 aagacaaatc cagaatttgg gacatcttat aatttagttg ccctggattc ttcaaaagtt
      181 taagctatga agaaggacat ccctcacact ctgaaacaga tctccttcag agacagagtt
      241 ttgcagcctc tcatcagctt cctggatatg ctcccacacc tcagcctact ggtctttctg
      301 gaatatttga tactagtgtg aacagtgcca gcagtaacac taaagagtct tcagtgatga
      361 attttctgtc tactgctgaa tcccgaactg ctcaggctgc tgcttcagga actactctct
      421 taccacaatt cagggctcca tcctggcaga caggcatgca ttcctcagca gcaactgagc
      481 tgtttgctac tggacctttg ccaagcactg gaacacttcc accatctctc tctgcttatc
      541 agcatcccac caccttcagc aatagaaact ttgctaccac ttcacctttg gtgcttcagg
      601 attcaacttt taacactaca tcaaatggaa ttttaagtca tcatgaccct ttgctacaaa
      661 tcaagacttc ccagggaact gttccaactg ctttggcatt tgagcgcctg ggcagttctg
      721 tattaagtaa cagcatacca cctcagtctt caacataccg ctcagctcaa gagtctgcac
      781 cccatctttt acaacctcaa tttagtttgt tgccttcagc acttggggga tcccagcaga
      841 ctcctcaagc ctacagttca actctcttta ctagttctac tgcttccatt gaaagagctc
      901 ttcttcgaga atgtagtgtt attaaacacc atcagcggcc ttcaggtacc cagtcaattc
      961 aggcacaact gactggttca cagcactcct tacatagtta tctatcaaat tcaagtgtag
     1021 ttaattttca ggaaacaacc aggcagtcat ctttatcctg tagcccaatt ggagattcca
     1081 ctcagaattt gccagactct agcccgaccc agaattatat ttctatgcat tcttcccaaa
     1141 atgttcagac tcaagagtca tcatctcccc agtcccagaa gtttttgcct gctgtccagt
     1201 catcatcttt tgcatcctct actcattgtc agacattaca aaataacata acttcccctg
     1261 acccaaagtc ttatgctgaa agaaagcttg actcagatgt gtatccatct tcaaagcaag
     1321 aagatggttt tccaatgcaa gagttacagg tgttgcagcc acaagcatct cttgagtcat
     1381 caacccaaag gctatctgat ggagaaatta atgctcaaga atcaacttat aaggtgtcaa
     1441 aggcagatga cagatattct cagagtgtaa tcagaagtaa ttcccgtctt gaagatcaag
     1501 ttattggggt tgctctgcaa gcatcaaaaa aagaagaaag tgttgttggt tcagtgacac
     1561 aacttaacca acaaattggc caagtcaata atgcagctac ccttgatctt aagaactcaa
     1621 ctaatttaat acagactcca caaataaggt tgaatactaa agacttaaag cagcaacatc
     1681 ctctcatact taaggtgcat gagtccaagg tccaggaaca gcacgatcaa ataattaatg
     1741 cttcatctca gattcaaatt ccaaatcatg ctttagggca tggccatcag gcatctcttc
     1801 ctaatacaca ggtcctttta gattctgcct gtgatttaca aattcttcag cagtcaatac
     1861 tgcaggcagg tttaggtcaa gtaaaggcat ctttacaagc acagcgtgtt caaagccctc
     1921 aacaaatagt acatcccttc cttcagatgg aaggtcatgt tattcaaagc aatggtgatc
     1981 attctcagca gcaactccat cctcaaaatt ctgaagttat gaaaatggac ctctctgagt
     2041 cttcaaaacc attacaacaa catctaacaa caaagggcca ttttagtgaa acaaatcaac
     2101 atgattcaaa gaatcagttt gtttctcttg gatcgatgtg tttcccagag gcagtgcttc
     2161 ttagtgatga aagaaatatt ttatcaaatg tagatgatat cttagcagct acagcagcag
     2221 cttgtggagt tacacctact gatttttcca agtcaacttc aaatgaaacc atgcaggctg
     2281 ttgaagatgg tgattctaaa tctcattttc agcagtcatt agatgtcagg catgtgactt
     2341 cagattttaa ctctatgaca gctacagtag gaaagccaca gaatataaat gatacttcct
     2401 taaatggaaa tcaggttact gtgaaccttt caccagtacc tgcccttcag tcaaaaatga
     2461 ctcttgatca acagcacatt gaaacacctg gtcaaaatat accaactaaa gtaacttcag
     2521 cagtggttgg accaagtcat gaagtccagg agcaaagttc tggcccattc aagaaacagt
     2581 ctgctaccaa tcttgaatct gaagaagaca gtgaagctcc tgttgatagt acattaaata
     2641 ataacagaaa ccaagagttt gtttctagta gtagaagtat aagtggagag agtgctacat
     2701 cagagagtga atttacctta gggggtgacg acagtggtgt gtcaatgaac ccagctagga
     2761 gtgcacttgc actgttggcc atggcccaat ctggggatgc agtcagtgtc aagattgaag
     2821 aagaaaacca agatttaatg cattttaacc ttcaaaagaa aagagctaaa ggaaaagggc
     2881 aagttaaaga ggaagacaac agtaatcaga aacagctgaa aagacctgcc caaggcaaac
     2941 gccagaatcc aaggggaaca gatatttact taccgtatac tcctccttcc tcagaaagct
     3001 gccatgatgg ttatcagcat caagaaaaaa tgagacagaa gatcaaagag gtggaggaaa
     3061 aacaaccgga agtcaaaaca ggatttattg cttctttctt agattttctg aaatccgggc
     3121 ccaagcagca gttttccact cttgctgtac gaatgcctaa caggactaga cggccaggga
     3181 cccagatggt tcgtacattt tgtcccccac cacttcccaa gccttcatct acaacaccca
     3241 cacctttagt gtctgaaact ggcggtaaca gtccatcaga taaagttgat aatgaactta
     3301 aaaacttgga acatttatct tcattttctt ctgatgaaga tgatcctgga tatagtcaag
     3361 atgcttataa aagcgtctct actcccttaa ctactttgga tgctacttct gataaaaaga
     3421 agaaaacaga agccctacag gtggcaacta ctagcccaac tgccaatact actggtactg
     3481 ctactacttc ctcaaccact gtgggtgcag ttaagcaaga acctctccac tctacttcat
     3541 atgcagtaaa tattctggaa aatataagct cttcagaatc ctcaaagccc attgaacttg
     3601 atggtcttcc ttcagaccag tttgcaaaag gacaggacac tgttgccata gaaggtttta
     3661 cagatgagga ggacacagaa agcggaggag aaggccaata cagagagcgt gatgaatttg
     3721 tggtaaagat agaagacata gagactttta aggaggcttt aaaaacagga aaagaacctc
     3781 cagctatttg gaaagtacaa aaagctttat tacagaaatt tgttcctgaa attcgagatg
     3841 gtcaaagaga atttgctgct acaaatagtt atcttggata ttttggagat gcaaagagta
     3901 aatacaaaag aatatatgtg aagttcattg aaaatgcaaa caagaaggaa tatgtcagag
     3961 tgtgttctaa aaagccaaga aataaacctt cacaaactat cagaactgtt caagctaagc
     4021 caagtagtag cagtaaaact tctgatcctc tagcatcaaa aactacaact acaaaagccc
     4081 cttccgtgaa acccaaagtt aaacagccaa aagtaaaggc tgagccacca ccaaagaaac
     4141 ggaaaaaatg gaaagaagaa ttttcatcat cccaatctga ctcatctcct gagatccata
     4201 ctagtagtag tgacgatgag gaatttgaac ctcccgctcc ctttgtcact cgctttttga
     4261 acacaagagc aatgaaggaa acctttaaga gctacatgga atagcttgtt agcattgcct
     4321 tggaccctga cacaatgcaa gccttagaga agagcaatga tgagctactt ttacctcata
     4381 tgaaaaaaat agatggcatg ctaaatgata accgaaagag acttcttttg aatcttcatt
     4441 tggatcaatc attcaagaat gctttggaaa gttttcctga actaacaata attactcgag
     4501 attctaaagc aaagagtgga ggaactgcta tttctaaaat caaaatgaat ggcaaagcct
     4561 ataataagaa aactctaagg acttctaaaa caaccaccaa atctgcacaa gagtttgctg
     4621 tcgatccaga gaaaatacag ttgtattctt tgtatcattc actccatcat tataagtacc
     4681 atgtttatct gatatgtaag gatgagattt cttcggtgca gaaaaaaaat gaagatttag
     4741 gacaggagga aattgttcaa ctttgtatga aaaatgtaaa atgggtggag gacctctttg
     4801 aaaaatttgg agaacttcta aatcataccg gaatgttggg agaaatgcaa agcgtctcag
     4861 ttagcagcac cagaagatca gagcagcaga atattctaga ggctgggaag tccaagatca
     4921 aggtacctgt atctggtgac tgttgagagc cttcttgctg tgccttagaa tgaaagaagg
     4981 tggagggcaa ggtgatatga acaatgtgcc tttacatggc aaaagaatga aagaaagtaa
     5041 acctattccc ac
//

LOCUS       NM_024792               2096 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens membrane protein expressed in epithelial-like lung
            adenocarcinoma (CT120), mRNA.
ACCESSION   NM_024792
VERSION     NM_024792.1  GI:13376161
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   He,X., Di,Y., Li,J., Xie,Y., Tang,Y., Zhang,F., Wei,L., Zhang,Y.,
            Qin,W., Huo,K., Li,Y., Wan,D. and Gu,J.
  TITLE     Molecular cloning and characterization of CT120, a novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
  JOURNAL   Biochem. Biophys. Res. Commun. 297 (3), 528-536 (2002)
   PUBMED   12270127
  REMARK    GeneRIF: Molecular cloning and characterization of this novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK025935.1.
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..2096
                     /gene="CT120"
                     /note="synonym: FLJ22282"
                     /db_xref="GeneID:79850"
     CDS             42..815
                     /gene="CT120"
                     /note="go_component: integral to membrane [goid 0016021]
                     [evidence IEA]"
                     /codon_start=1
                     /product="membrane protein expressed in epithelial-like
                     lung adenocarcinoma"
                     /protein_id="NP_079068.1"
                     /db_xref="GI:13376162"
                     /db_xref="GeneID:79850"
                     /translation="MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVS
                     SVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQ
                     NRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQRLRGDLGDFFVGCIFTAELSTPFV
                     SLGRVLIQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSI
                     PFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG"
ORIGIN      
        1 agccacgcgg cgccagcgag gcggccggac ccgcagcccc gatgctgctg acgctggccg
       61 ggggcgcgct cttcttcccg gggctcttcg cgctctgcac ctgggcgctg cgccgctccc
      121 agcccggatg gagccgcacc gactgcgtga tgatcagcac caggctggtt tcctcggtgc
      181 acgccgtgct ggccaccggc tcggggatcg tcatcattcg ctcctgcgac gacgtgatca
      241 ccggcaggca ctggcttgcc cgggaatatg tgtggtttct gattccatac atgatctatg
      301 actcgtacgc catgtacctc tgtgaatggt gccgaaccag agaccagaac cgtgcgccct
      361 ccctcactct tcgaaacttc ctaagtcgaa accgcctcat gatcacacat catgcggtca
      421 ttctctttgt ccttgtgcca gtcgcacaga ggctccgggg agaccttggg gacttctttg
      481 tcggctgcat cttcacggca gaactgagca ctccgtttgt gtcgctgggc agggttctga
      541 ttcagctaaa gcagcagcac acccttctgt acaaggtgaa tggaatcctc acgctggcca
      601 ccttcctttc ctgccggatc cttctcttcc ccttcatgta ctggtcctat ggccgccagc
      661 agggactaag cctgctccaa gtacccttca gcatcccatt ctactgcaac gtggccaatg
      721 ccttcctcgt agctcctcag atctactggt tctgtctgct gtgcaggaag gcagtccggc
      781 tctttgacac tccccaagcc aaaaaggatg gctaaatgct cctgggagtc aggcgcagcc
      841 tcacaccagc tgcctcctcc actcagcatt ccatggacca aattgtgccc tgggtagcct
      901 cagactttgg gtattgataa gccgatggat ttgagttttt ctaaagaata ttcatattac
      961 ctccttcttc taacttgccc tatttgcaaa agcacttttg tagtaacaac tattgggtcc
     1021 tgtcagacct ccacggacag caaagtggtt ttaatgcaag cccaaggatc cttcttaagg
     1081 tcttatctca agagctctgg gaggtggaag catggggtgg gatcggtgga ccagggtggt
     1141 aagtgtctgc acatctgcct gtccctgtat cagcggctac ccaccttcca aaccactcag
     1201 gacagtaccc gtggcactgg gcccgcagaa gcaagggatg acttggttct tggaagtaat
     1261 gtcgtcttgt gacattggcc tgggacaatc attgtgggta ggtagttatt gatcgtttac
     1321 tagataaccc attggttctt tgcctcatcc tctcatccat gggtcagagt tgaattctta
     1381 tgtctataga cttccaatca gaagtctcac tggtggggct gggggtgggg gcaggcagga
     1441 ggcatggatg ggaacctgag taggtagtgt ggccaagaga tcagcacaac ctttgcaggc
     1501 tgacttgcta agtctgacag tgacaaactt gtgagcttac tgcagtcagt cacagaggct
     1561 gttctttttc acacacccct tcatgcccgg ctttccccat atccacatgc agagggcgag
     1621 ctcataaaac tacagggaag cgtgaaatga tggctttggt agctgtttac tgggtaaccc
     1681 cactgtgaca ctgtcctttt catgtgatgt ggaaacctac ttctgtcctc caaaccatga
     1741 aatgtgtcat ctagactgca gagtacttga gtgctttgcc tcccgatatg ccagagcttg
     1801 tggtccaaag cccattcctg tgtgtccgtc ctgccattta gccacagaag gctgcggagt
     1861 gaggcggcag ctagcctggc cagtggctgt cccgtggacc gacacctgcg cccccttctg
     1921 caagcaggat tttctggtgc caacactcat tcatcattcc cgatcaacta ggatgaattt
     1981 aagactgtgc taccatgtgt tctcaagtgg tagtttaaaa agtggatttt taaagtgcct
     2041 ttcaattgtc tgtgaacgtc taaaggactg atttgtctca aaaaaaaaaa aaaaaa
//

LOCUS       NM_030935               2399 bp    mRNA    linear   PRI 15-OCT-2004
DEFINITION  Homo sapiens TSC-22-like (THG-1), mRNA.
ACCESSION   NM_030935
VERSION     NM_030935.3  GI:37059797
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Kester,H.A., Blanchetot,C., den Hertog,J., van der Saag,P.T. and
            van der Burg,B.
  TITLE     Transforming growth factor-beta-stimulated clone-22 is a member of
            a family of leucine zipper proteins that can homo- and
            heterodimerize and has transcriptional repressor activity
  JOURNAL   J. Biol. Chem. 274 (39), 27439-27447 (1999)
   PUBMED   10488076
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC001486.2.
            On Sep 30, 2003 this sequence version replaced gi:31543807.
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21-p15"
     gene            1..2399
                     /gene="THG-1"
                     /db_xref="GeneID:81628"
     CDS             756..1943
                     /gene="THG-1"
                     /note="go_component: nucleus [goid 0005634] [evidence
                     IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_function: transcriptional repressor activity [goid
                     0016564] [evidence NAS];
                     go_function: transcriptional repressor activity [goid
                     0016564] [evidence NAS] [pmid 10488076];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence NAS]"
                     /codon_start=1
                     /product="TSC-22-like"
                     /protein_id="NP_112197.1"
                     /db_xref="GI:13569901"
                     /db_xref="GeneID:81628"
                     /translation="MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLP
                     NGEPSPDPGGKGTPRNGSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEP
                     HSFGGLLEGIRGASGGAGGRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPG
                     PQARSFTGGLGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRV
                     EAEAGGSGARTPPLSRRKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLV
                     HKSPDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLM
                     FAVREEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNG
                     PSV"
ORIGIN      
        1 ggaggaggag gaggaggaga ggagcagtca gcaggcccga ggaggcagga cttcctggtg
       61 tgggggttgt caacagccca gaaagagaaa gacggagagg cagagaccca ggggagccga
      121 ggagcggaga cacggaccca gcagggtcac gcgggaggag actcgggaca cccactcgct
      181 ggctgccacc gggagcagag gggggctcgg ccgccccctc ccacatcagt ctccagaccc
      241 ttggggcttc agaggccgct cctaggctcc tcggaggagg cgcgggttcc ttcttttccg
      301 gagagcaaac tttcctcgga gatgcctggc aggatgagcc gcggcccccg gagaggacgg
      361 gacagcctct gatcgccgcc tgcgtgcccc gccactgccc atggccagga ggccccaggg
      421 aacggacagc ccgacctctt aggcgccggg accctcaggc tcagatcagt ggccgaggcc
      481 ccagagtttg caaactcagc tctggagttc agcagcaaca gcagcaggaa aaacctgccc
      541 ctgctccccc ctcccgccac ctcccctctc ctcttctccc ctcacccagc aggcaccccc
      601 ggttcccgcc aggccctcct gccatgtcgg acccagacgt ccccaggggc tcggatgtcc
      661 ccgccatgtg gcccccttgt tccaggggtg cctgagcccc ttcaaggagc cccaacccac
      721 ccccaacctt ggcccagccc tgagccccag ggaccatgag cgggggcaag aagaagagta
      781 gtttccaaat caccagcgtc accacggact atgagggccc tgggagccca ggggcttcgg
      841 atccccctac cccacagccc ccaaccgggc ccccgccccg cctgcccaat ggggagccca
      901 gccccgatcc ggggggcaag ggcacccccc ggaatggctc cccaccacct ggggcccctt
      961 cctcccgttt ccgggtggtg aagctgcccc acggcctggg agagccttat cgccgcggtc
     1021 gctggacgtg tgtggatgtt tatgagcgag acctggagcc ccacagcttc ggcggactcc
     1081 tggagggaat tcgaggggcc tcagggggcg ccgggggcag atctttggat tccaggttgg
     1141 agctggccag cctcggcctg ggcgccccca ccccaccgtc aggcctgtct cagggcccca
     1201 cctcctggct ccgtccaccc cccacctctc ctggacctca ggcccgctcc ttcactgggg
     1261 gactgggcca gctggtggtg cccagcaaag ccaaggcaga gaaaccccca ctgtcggcct
     1321 cctcacccca gcagcgcccc ccagagcctg agaccggtga gagtgcgggc acatcccggg
     1381 ctgccacgcc cctgccctct ctgagggtgg aagcggaggc tgggggctca ggggccagga
     1441 cccctccact gtcccggagg aaagctgtag acatgcggct gcggatggag ttgggtgctc
     1501 cagaagagat ggggcaggtg cccccacttg actctcgccc cagctccccg gccctctact
     1561 tcacccacga tgccagcctg gttcacaaat ctccagaccc cttcggagca gtagcagctc
     1621 agaagttcag cctggcccac tccatgttgg ccatcagtgg tcacctagac agcgacgatg
     1681 atagtggctc cggaagcctg gttggcattg acaacaaaat cgagcaagcc atggacttgg
     1741 tgaagtccca cctcatgttt gcggtccggg aggaggtgga ggtgctgaag gagcagatcc
     1801 gggaactggc ggagcggaac gctgcgctgg agcaggagaa tgggctgctg cgcgccctgg
     1861 ccagcccgga gcagctggct cagctgccct cctcgggggt cccacggctt gggccccctg
     1921 cgcccaatgg gccctccgtc tgagcctccc ttcccttaca atgtgccttt ggggctgccc
     1981 ggccttgcgt cagccgcctg ccccctcttc ctatgcagct ttaatgtccc cgtgtccccg
     2041 gggtgggagt tcaaggctca gtaatggcct ggtcccccgg cccctgcccc atctcctcat
     2101 catccccagc cttgatggag gagggagggc ttcaggacgg ggcgtcagag ggagccccct
     2161 ctgggaggga accaaccccc accctccctc ctgggacccc ccagcagtag acggcttggg
     2221 ggagtcggag gctccccggc agacacccca cccccatctt gttcccttga ggtgcctcct
     2281 ctcctctgcc caggggaggg agtgtggaca gtatctggaa gttctgggat tcaggttgtt
     2341 attaaaataa taataataat taaaaactct gaagaaactt gaaaaaaaaa aaaaaaaaa
//

LOCUS       NM_031437               3498 bp    mRNA    linear   PRI 19-JAN-2005
DEFINITION  Homo sapiens Ras association (RalGDS/AF-6) domain family 5
            (RASSF5), transcript variant 4, mRNA.
ACCESSION   NM_031437
VERSION     NM_031437.1  GI:13899264
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Irimia,M., Fraga,M.F., Sanchez-Cespedes,M. and Esteller,M.
  TITLE     CpG island promoter hypermethylation of the Ras-effector gene
            NORE1A occurs in the context of a wild-type K-ras in lung cancer
  JOURNAL   Oncogene 23 (53), 8695-8699 (2004)
   PUBMED   15378027
  REMARK    GeneRIF: the epigenetic alteration of NORE1A is confined to lung
            tumors with a wild-type K-ras: 88% (15 of 17) of the tumors with
            NORE1 hypermethylation did not harbor a K-ras mutation (P=0.008,
            Fisher's exact test)
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Katagiri,K., Maeda,A., Shimonaka,M. and Kinashi,T.
  TITLE     RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion
            through spatial regulation of LFA-1
  JOURNAL   Nat. Immunol. 4 (8), 741-748 (2003)
  MEDLINE   22770734
   PUBMED   12845325
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Vos,M.D., Martinez,A., Ellis,C.A., Vallecorsa,T. and Clark,G.J.
  TITLE     The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated
            tumor suppressor in the lung
  JOURNAL   J. Biol. Chem. 278 (24), 21938-21943 (2003)
  MEDLINE   22679182
   PUBMED   12676952
  REMARK    GeneRIF: Nore1 is a member of a family of Ras effector/tumor
            suppressors that includes RASSF1
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Tommasi,S., Dammann,R., Jin,S.G., Zhang Xf,X.F., Avruch,J. and
            Pfeifer,G.P.
  TITLE     RASSF3 and NORE1: identification and cloning of two human
            homologues of the putative tumor suppressor gene RASSF1
  JOURNAL   Oncogene 21 (17), 2713-2720 (2002)
  MEDLINE   21962323
   PUBMED   11965544
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Yao,R., Wang,Y. and You,M.
  TITLE     Chromosome mapping and sequence variation of the murine Ras
            effector gene Nore1
  JOURNAL   Cytogenet. Cell Genet. 95 (1-2), 126-128 (2001)
  MEDLINE   21974651
   PUBMED   11978988
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC004270.1.
            
            Summary: The RAS oncogene (MIM 190020) is mutated in nearly
            one-third of all human cancers. Members of the RAS superfamily are
            plasma membrane GTP-binding proteins that modulate intracellular
            signal transduction pathways. A subfamily of RAS effectors,
            including NORE1, share a RAS association (RA) domain.[supplied by
            OMIM].
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3498
                     /gene="RASSF5"
                     /note="synonyms: RAPL, Maxp1, NORE1, RASSF3, MGC10823"
                     /db_xref="GeneID:83593"
                     /db_xref="MIM:607020"
     CDS             64..1236
                     /gene="RASSF5"
                     /note="isoform D is encoded by transcript variant 4;
                     Rap1-binding protein; Ras association (RalGDS\/AF-6)
                     domain family 5;
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_function: diacylglycerol binding [goid 0019992]
                     [evidence IEA];
                     go_process: cell cycle [goid 0007049] [evidence IEA];
                     go_process: signal transduction [goid 0007165] [evidence
                     IEA];
                     go_process: intracellular signaling cascade [goid 0007242]
                     [evidence IEA]"
                     /codon_start=1
                     /product="Ras association (RalGDS/AF-6) domain family 5
                     isoform D"
                     /protein_id="NP_113625.1"
                     /db_xref="GI:13899265"
                     /db_xref="GeneID:83593"
                     /db_xref="MIM:607020"
                     /translation="MASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCV
                     PAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVR
                     SIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPEC
                     RSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNT
                     REKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRT
                     SFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLS
                     IADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLSSWCIQIYLYY"
ORIGIN      
        1 cgggagtagc gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggcatg
       61 gccatggcgt ccccggccat cgggcagcgc ccgtacccgc tactcttgga ccccgagccg
      121 ccgcgctatc tacagagcct gagcggcccc gagctaccgc cgccgccccc cgaccggtcc
      181 tcgcgcctct gtgtcccggc gcccctctcc actgcgcccg gggcgcgcga ggggcgcagc
      241 gcccggaggg ctgcccgggg gaacctggag cccccgcccc gggcctcccg acccgctcgc
      301 ccgctccggc ctggtctgca gcagagactg cggcggcggc ctggagcgcc ccgaccccgc
      361 gacgtgcgga gcatcttcga gcagccgcag gatcccagag tcccggcgga gcgaggcgag
      421 gggcactgct tcgccgagtt ggtgctgccg ggcggccccg gctggtgtga cctgtgcgga
      481 cgagaggtgc tgcggcaggc gctgcgctgc actaactgta aattcacctg tcacccagaa
      541 tgccgcagcc tgatccagtt ggactgcagt cagcaggagg gtttatcccg ggacagaccc
      601 tctccagaaa gcaccctcac cgtgaccttc agccagaatg tctgtaaacc tgtggaggag
      661 acacagcgcc cgcccacact gcaggagatc aagcagaaga tcgacagcta caacacgcga
      721 gagaagaact gcctgggcat gaaactgagt gaagacggca cctacacggg tttcatcaaa
      781 gtgcatctga aactccggcg gcctgtgacg gtgcctgctg ggatccggcc ccagtccatc
      841 tatgatgcca tcaaggaggt gaacctggcg gctaccacgg acaagcggac atccttctac
      901 ctgcccctag atgccatcaa gcagctgcac atcagcagca ccaccaccgt cagtgaggtc
      961 atccaggggc tgctcaagaa gttcatggtt gtggacaatc cccagaagtt tgcacttttt
     1021 aagcggatac acaaggacgg acaagtgctc ttccagaaac tctccattgc tgaccgcccc
     1081 ctctacctgc gcctgcttgc tgggcctgac acggaggtcc tcagctttgt gctaaaggag
     1141 aatgaaactg gagaggtaga gtgggatgcc ttctccatcc ctgaacttca gaacttcctc
     1201 tcctcctggt gcattcagat ttatttgtat tattaattat tattttgcaa cagacacttt
     1261 ttctcaggac atctctggca ggtgcatttg tgcctgccca gcagttccag ctgtggcaaa
     1321 agtctcttcc atggacaagt gtttgcacga gggttcagct gtgcccgccc ccaggctgtg
     1381 ccccaccaca gattctgcca aggatcagaa ctcatgtgaa acaaacagct gacgtcctct
     1441 ctcgatctgc aagcctttca ccaaccaaat agttgcctct ctcgtcacca aactggaacc
     1501 tcacaccagc cggcaaagga aggaagaaag gttttagagc tgtgtgttct ttctctggca
     1561 ttgattcctc tttgagttct cttacttgcc acgtacagga ccattattta tgagtgaaaa
     1621 gttgtagcac attccttttg caggtctgag ctaagcccct gaaagcaggg taatgctcat
     1681 aaaaggactg ttcccgcggc cccaaggtgc ctgttgttca cacttaaggg aagtttataa
     1741 agctactggc cccagatgct cagggtaagg agcaccaaag ctgaggctgg ctcagagatc
     1801 tccagagaag ctgcagcctg ccctggccct ggctctggcc ctggcccaca ttgcacatgg
     1861 aaacccaaag gcatatatct gcgtatgtgt ggtacttagt cacatctttg tcaacaaact
     1921 gttcgttttt aagttacaaa tttgaattta atgttgtcat catcgtcatg tgtttcccca
     1981 aagggaagcc agtcattgac catttaaaaa gtctcctgct aagtatggaa atcagacagt
     2041 aagagaaagc caaaaagcaa tgcagagaaa ggtgtccaag ctgtcttcag ccttccccag
     2101 ctaaagagca gaggagggcc tgggctactt gggttcccca tcggcctcca gcactgcctc
     2161 cctcctccca ctgcgactct gggatctcca ggtgctgccc aaggagttgc cttgattaca
     2221 gagaggggag cctccaattc ggccaacttg gagtcctttc tgttttgaag catgggccag
     2281 acccggcact gcgctcggag agccggtggg cctggcctcc ccgtcgacct cagtgccttt
     2341 ttgttttcag agagaaatag gagtagggcg agtttgcctg aagctctgct gctggcttct
     2401 cctgccagga agtgaacaat ggcggcggtg tgggagacaa ggccaggaga gcccgcgttc
     2461 agtatgggtt gagggtcaca gacctccctc ccatctgggt gcctgagttt tgactccaat
     2521 cagtgatacc agaccacatt gacagggagg atcaaattcc tgacttacat ttgcactggc
     2581 ttcttgttta ggctgaatcc taaaataaat tagtcaaaaa attccaacaa gtagccagga
     2641 ctgcagagac actccagtgc agagggagaa ggacttgtaa ttttcaaagc agggctggtt
     2701 ttccaaccca gcctctgaga aaccatttct ttgctatcct ctgccttccc aagtccctct
     2761 tgggtcggtt caagcccaag cttgttcgtg tagcttcaga agttccctct ctgacccagg
     2821 ctgagtccat actgcccctg atcccagaag gaatgctgac ccctcgtcgt atgaactgtg
     2881 catagtctcc agagcttcaa aggcaacaca agctcgcaac tctaagattt ttttaaacca
     2941 caaaaaccct ggttagccat ctcatgctca gccttatcac ttccctccct ttagaaactc
     3001 tctccctgct gtatattaaa gggagcaggt ggagagtcat tttccttcgt cctgcatgtc
     3061 tctaacatta atagaaggca tggctcctgc tgcaaccgct gtgaatgctg ctgagaacct
     3121 ccctctatgg ggatggctat tttatttttg agaaggaaaa aaaaagtcat gtatatatac
     3181 acataaaggc atatagctat atataaagag ataagggtgt ttatgaaatg agaaaattat
     3241 tggacaattc agactttact aaagcacagt tagacccaag gcctatgctg aggtctaaac
     3301 ctctgaaaaa agtatagtat cgagtacccg ttccctccca gaggtgggag taactgctgg
     3361 tagtgccttc tttggttgtg ttgctcagtg tgtaagtgtt tgtttccagg atattttctt
     3421 tttaaatgtc tttcttatat gggttttaaa aaaaagtaat aaaagcctgt tgcaaaaatg
     3481 aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_031942               2824 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens cell division cycle associated 7 (CDCA7), transcript
            variant 1, mRNA.
ACCESSION   NM_031942
VERSION     NM_031942.3  GI:22027512
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2824)
  AUTHORS   Prescott,J.E., Osthus,R.C., Lee,L.A., Lewis,B.C., Shim,H.,
            Barrett,J.F., Guo,Q., Hawkins,A.L., Griffin,C.A. and Dang,C.V.
  TITLE     A novel c-Myc-responsive gene, JPO1, participates in neoplastic
            transformation
  JOURNAL   J. Biol. Chem. 276 (51), 48276-48284 (2001)
   PUBMED   11598121
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK027628.1, AK027642.1 and
            AY029179.1.
            On Jul 31, 2002 this sequence version replaced gi:21362007.
            
            Summary: This gene was identified as a c-Myc responsive gene, and
            behaves as a direct c-Myc target gene. Overexpression of this gene
            is found to enhance the transformation of lymphoblastoid cells, and
            it complements a transformation-defective Myc Box II mutant,
            suggesting its involvement in c-Myc-mediated cell transformation.
            Two alternatively spliced transcript variants encoding distinct
            isoforms have been reported.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2824
                     /gene="CDCA7"
                     /note="synonyms: JPO1, FLJ14722, FLJ14736, MGC34109"
                     /db_xref="GeneID:83879"
     CDS             145..1497
                     /gene="CDCA7"
                     /note="isoform 1 is encoded by transcript variant 1; c-Myc
                     target JPO1;
                     go_process: cytokinesis [goid 0000910] [evidence IEA]"
                     /codon_start=1
                     /product="cell division cycle associated protein 7 isoform
                     1"
                     /protein_id="NP_114148.2"
                     /db_xref="GI:21362008"
                     /db_xref="GeneID:83879"
                     /translation="MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASD
                     NFANTKPKFRSDISEELASVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNE
                     LAGIFHADSDDESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARST
                     RGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESF
                     PGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPME
                     EEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCS
                     NSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDAL
                     LDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
                     "
     polyA_signal    2719..2724
                     /gene="CDCA7"
     polyA_site      2735
                     /gene="CDCA7"
                     /evidence=experimental
     polyA_signal    2799..2804
                     /gene="CDCA7"
     polyA_site      2823
                     /gene="CDCA7"
                     /evidence=experimental
     polyA_site      2824
                     /gene="CDCA7"
                     /evidence=experimental
ORIGIN      
        1 cccgagcccc gcccctccgg gcccgggtcg gcgcgcccag cctgccagcc gcgctgctgc
       61 tgctcctcct gctgtgggac cgctgaccgc gcggctgctc cgctctcccc gctccaagcg
      121 ccgatctggg cacccgccac cagcatggac gctcgccgcg tgccgcagaa agatctcaga
      181 gtaaagaaga acttaaagaa attcagatat gtgaagttga tttccatgga aacctcgtca
      241 tcctctgatg acagttgtga cagctttgct tctgataatt ttgcaaacac gaaacctaaa
      301 ttcaggtcag atatcagtga agaactggca agtgtttttt atgaggactc tgataatgaa
      361 tctttctgcg gcttttcaga aagtgaggtg caagatgtat tagaccattg tggattttta
      421 cagaaaccaa ggccagatgt cactaacgaa ctggccggta tttttcatgc cgactctgac
      481 gatgaatcat tttgcggttt ctcagagagt gagatacaag atggaatgag gctgcagtca
      541 gttcgggaag gctgtaggac ccgcagccag tgcaggcact ctggacctct cagggtggcg
      601 atgaagtttc cagcgcggag taccagggga gcaaccaaca aaaaagcaga gtcccgccag
      661 ccctcagaga attctgtgac tgattccaac tccgattcag aagatgaaag tggaatgaat
      721 tttttggaga aaagggcttt aaatataaag caaaacaaag caatgcttgc aaaactcatg
      781 tctgaattag aaagcttccc tggctcgttc cgtggaagac atcccctccc aggctccgac
      841 tcacaatcaa ggagaccgcg aaggcgtaca ttcccgggtg ttgcttccag gagaaaccct
      901 gaacggagag ctcgtcctct taccaggtca aggtcccgga tcctcgggtc ccttgacgct
      961 ctacccatgg aggaggagga ggaagaggat aagtacatgt tggtgagaaa gaggaagacc
     1021 gtggatggct acatgaatga agatgacctg cccagaagcc gtcgctccag atcatccgtg
     1081 acccttccgc atataattcg cccagtggaa gaaattacag aggaggagtt ggagaacgtc
     1141 tgcagcaatt ctcgagagaa gatatataac cgttcactgg gctctacttg tcatcaatgc
     1201 cgtcagaaga ctattgatac caaaacaaac tgcagaaacc cagactgctg gggcgttcga
     1261 ggccagttct gtggcccctg ccttcgaaac cgttatggtg aagaggtcag ggatgctctg
     1321 ctggatccga actggcattg cccgccttgt cgaggaatct gcaactgcag tttctgccgg
     1381 cagcgagatg gacggtgtgc gactggggtc cttgtgtatt tagccaaata tcatggcttt
     1441 gggaatgtgc atgcctactt gaaaagcctg aaacaggaat ttgaaatgca agcataatat
     1501 ctggaaaatt tgctgcctgc cttctacttc tcaaatcttt cttgtaaaag tttccaattt
     1561 tttcactgaa acctgagtta aaaatcttga tgatcagcct gtttcataag aaactccaat
     1621 caagttaatc ttagcagaca tgtgtttctg gagcatcaca gaaggtatat tgctagttac
     1681 actttgccct cctgcagttt cttctctgct cccaaccccc atctcatagc atccccctct
     1741 atttccaatg ctcctctcca accgcttagt ttctgaattt cttttaaatt acagttttat
     1801 gaaagcatat tttatttact tggtgttgaa atagccctca taaaacctaa gcacttggaa
     1861 acacaataat agtattaact aactagatct attgaatttc agagaagagc cttctaactt
     1921 gtttacacaa aaacgagtat gatttagcat tcatactagt tgaaattttt aatagaatca
     1981 aggcacaaaa gtcttaaaac catgtggaaa aattaggtaa ttattgcaga ttgatgtctc
     2041 tcaatcccat gtattgcgct tatgttacaa gttgttgtca cagttgagac ttaatttctc
     2101 ctaatttctt ctgcccgaag ggtaagtggt gcgtccagct tacacaatca taattcaaag
     2161 gttggtgggc aatgtaatac ttaattaaaa taatgatgga agagctatct ggagattatg
     2221 agtaagctga tttgaatttt cagtataaaa ctttagtata attgtagttt gcaaagttta
     2281 tttcagttca catgtaaggt attgcaaata aattcttgga caattttgta tggaaacttg
     2341 atattaaaaa ctagtctgtg gttctttgca gtttcttgta aatttataaa ccaggcacaa
     2401 ggttcaagtt tagattttaa gcacttttat aacaatgata agtgcctttt tggagatgta
     2461 acttttagca gtttgttaac ctgacatctc tgccagtcta gtttctgggc aggtttcctg
     2521 tgtcagtatt ccccctcctc tttgcattaa tcaaggtatt tggtagaggt ggaatctaag
     2581 tgtttgtatg tccaatttac ttgcatatgt aaaccattgc tgtgccattc aatgtttgat
     2641 gcataattgg accttgaatc gataagtgta aatacagctt ttgatctgta atgcttttat
     2701 acaaaagttt attttaataa taaaatgttt gttctaactt gtctgctttt ttaaaaataa
     2761 tcttactgta cttaattcta attttttcct catatttaaa taaaaggcca tttccacctt
     2821 ttct
//

LOCUS       NM_032139               4501 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens ankyrin repeat domain 27 (VPS9 domain) (ANKRD27),
            mRNA.
ACCESSION   NM_032139
VERSION     NM_032139.1  GI:14149802
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL136784.1.
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..4501
                     /gene="ANKRD27"
                     /note="synonyms: FLJ00040, DKFZP434L0718"
                     /db_xref="GeneID:84079"
     CDS             134..3286
                     /gene="ANKRD27"
                     /codon_start=1
                     /product="ankyrin repeat domain 27 (VPS9 domain)"
                     /protein_id="NP_115515.1"
                     /db_xref="GI:14149803"
                     /db_xref="GeneID:84079"
                     /translation="MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLS
                     SSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYN
                     EKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFH
                     RTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHH
                     EIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNK
                     CTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSY
                     IKNFRFSSLAKDELGYCLTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQ
                     MTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
                     PSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGY
                     QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGD
                     TPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERR
                     QKSSEAPVQSPQRSVDSISQESSTSSFSSMSAGSRQEETKKDYREVEKLLRAVADGDL
                     EMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVT
                     SQDGSSPLHVAALHGRADLIRLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLD
                     SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV
                     FVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEY
                     VTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLH
                     EPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVS
                     QGPEAAGPLSTPQEVSASRS"
     polyA_site      4423
                     /gene="ANKRD27"
ORIGIN      
        1 gatcgccgcg cgagggtggt gggcatcgag gtcccagcag cggacgaggg aggtgccgcc
       61 gtcgcccagg atgggctggg aatgaagcga tgtagccttt taagagattt gctctgaccc
      121 atctgaagtc catatggctc tgtatgatga agacctcctg aaaaatcctt tctatctggc
      181 tctgcaaaag tgccgccctg acttgtgcag caaagtggcc caaatccatg gcattgtctt
      241 agtaccctgc aaaggaagcc tgtcgagcag catccagtct acttgtcagt ttgagtccta
      301 cattttgata cctgtggaag agcattttca gaccttaaat ggaaaggatg tctttattca
      361 agggaacagg attaaattag gagctggttt tgcctgtctt ctctcagtgc ccattctctt
      421 tgaagaaact ttctacaatg aaaaagaaga gagtttcagc atcctgtgta tagcccatcc
      481 tttggaaaag agagagagtt cagaagagcc tttggcaccc tcagatccct tttccctgaa
      541 aaccattgaa gatgtgagag agttcttggg aagacactcc gagcgatttg acaggaacat
      601 cgcctctttc catcgaacat tccgagaatg cgagagaaag agcctccgtc accacataga
      661 ctcagcgaat gctctctaca ccaaatgcct ccagcagctt ctgagggact ctcacctgaa
      721 aatgctcgcc aagcaggagg cccagatgaa cctgatgaag caggcagtgg agatatacgt
      781 ccatcatgaa atttacaacc tgatctttaa atacgtgggg accatggagg caagtgagga
      841 tgcggccttt aacaaaatca caagaagcct tcaagatctt cagcagaaag atattggtgt
      901 gaaaccggag ttcagcttta acatacctcg tgccaaaaga gagctggctc agctgaacaa
      961 atgcacctcc ccacagcaga agcttgtctg cttgcgaaaa gtggtgcagc tcattacaca
     1021 gtctccaagc cagagagtga acctggagac catgtgtgct gatgatctgc tatcagtcct
     1081 gttatacttg cttgtgaaaa cggagatccc taattggatg gcaaatttga gttacatcaa
     1141 aaacttcagg tttagcagct tggcaaagga tgaactggga tactgcctga cctcattcga
     1201 agctgccatt gaatatattc ggcaaggaag cctctctgct aaaccccctg agtctgaggg
     1261 atttggagac aggctgttcc ttaagcagag aatgagctta ctctctcaga tgacttcgtc
     1321 tcccaccgac tgcctgttta agcacattgc atcaggtaac cagaaagaag tggagagact
     1381 tctgagccaa gaggaccatg ataaagatac cgtccaaaag atgtgtcacc ctctctgctt
     1441 ctgcgatgac tgtgagaaac tcgtctctgg gaggttgaat gatccctcag ttgtcactcc
     1501 attctccaga gacgacaggg ggcacacccc tctccatgtg gctgctgtct gtgggcaggc
     1561 atccctcatc gacctcctgg tttccaaggg cgccatggta aatgccacag actaccatgg
     1621 ggccactccg ctccacctgg cctgtcagaa gggctaccag agcgtgacgc tgctgctgct
     1681 gcactacaag gccagcgcgg aagtgcagga caacaatggg aatacgccac tccacctggc
     1741 ctgcacctac ggccacgagg actgtgtgaa ggctctggtt tactacgacg tggagtcgtg
     1801 cagacttgac attggcaatg agaaaggaga cacccctcta cacattgctg cccgctgggg
     1861 ctaccaaggc gtcatagaga cattgctgca gaacggagcg tccaccgaga tccagaacag
     1921 actgaaggag acgcccctca agtgtgcatt aaactcaaag attctgtctg taatggaagc
     1981 ctatcacctg tccttcgaga ggaggcagaa gtcgtccgag gcccctgtgc agtccccgca
     2041 gcgctccgtg gactccatca gccaagagtc ctccacttcc agcttctcct ccatgtcagc
     2101 cggctcaagg caggaggaga ccaagaagga ctacagagag gtagaaaaac ttttgagagc
     2161 agttgctgat ggagatctag aaatggtgcg ttacctgttg gaatggacag aggaggacct
     2221 ggaggatgcg gaggacactg tcagtgcagc agaccccgaa ttctgtcacc cgttgtgcca
     2281 gtgccccaag tgtgccccag ctcagaagag gctggcgaag gttcctgcca gtgggcttgg
     2341 tgtgaacgtg accagccagg acggctcctc cccgctgcat gtcgccgccc tgcacggccg
     2401 ggcggacctc atccgcctcc tgctgaagca cggggccaac gcaggtgcca ggaacgcaga
     2461 ccaagccgtc ccgctccacc tggcctgcca gcagggccac tttcaggtgg tgaagtgtct
     2521 gttagattcg aatgcaaaac ccaataagaa ggacctcagt ggaaacacgc ccctcattta
     2581 cgcctgctcc ggtggccatc acgagcttgt ggcactgctg ctacagcacg gggcctccat
     2641 taacgcttct aacaataagg gcaacacagc gctgcacgag gctgtgattg aaaagcacgt
     2701 cttcgtggta gagctgcttc tgctccacgg agcgtcagtt caggtgctga acaagcggca
     2761 gcgcacggct gtagactgtg ctgaacagaa ttcaaaaata atggaattgc ttcaggtggt
     2821 accaagctgt gttgcttcat tagatgatgt ggctgaaact gaccgcaagg agtatgtcac
     2881 tgttaagatc aggaaaaaat ggaactcaaa actgtatgat ctaccagatg agccttttac
     2941 aagacagttt tactttgtcc actcagctgg tcagtttaag ggaaagactt caagggagat
     3001 tatggcaaga gatagaagtg tccctaattt aaccgaaggt tctttgcatg agccagggag
     3061 gcaaagtgtc acactgagac agaataacct gccagctcag agtggatctc atgctgctga
     3121 gaaaggcaac agcgactggc cagagaggcc tggactgaca cagactggcc ctggacacag
     3181 acggatgctg cggagacaca cggtagagga tgcggtcgtg tcccagggcc cggaggctgc
     3241 tggccccctc tccactcccc aagaggttag tgcttcccgg tcctaacagg aatgaggagt
     3301 tgttgaaccc actgctagga agcaaggatg caacaagatg atgctgagcg tgaacacatc
     3361 tgagaactaa atgtgcttcc atgagactgg cttgagaagt cttcagcacc aagttcctga
     3421 aagcttttct gtggcaggaa agaatgcaac aaaaaagtta accaccacca tctctctcct
     3481 cttcaaagct aatgaataca attgaaacag acaaaaattc cagtagcatc cagatcctta
     3541 agccagaggt gcatgcttct ttttaagtat gagggtttgt tggtcacagt gggagaggtt
     3601 tcaccaccgc attctgacct cctcctccca aaaggtgcta aacctctctg acctgtgtac
     3661 attcacaaac cacagctaga attcctccac ctaggattaa gctggagaga agtaagtaat
     3721 ttaggtttca tggtactgta gaggccaggc tgaaatgtca tatctgaagg aagaaagcag
     3781 cagctggaca atgtttcttt gcaaagcaac actcgaacca aaagatgcct caatcccatt
     3841 ttgatattca ttttagtgaa aggatgcatc agacctgttc cacatcatgc acatgggaaa
     3901 gggtggttat cattttcctt ctaacaagta ggtacagata ttcggttact acacgtgcac
     3961 ctgtagcagt atttctagaa acatcccttt ttgttgagaa cctcccttga atgtctgtca
     4021 cactcacacc tgacgggatg gttactggat tagagagtag atttggcaca tcttttctta
     4081 gtcttttgat tcaaattcaa aacttaacag cacaaaccag gtcagagtta ctttcggtta
     4141 gaatttattg ccatttattc ctttttataa atttctatag attatactgt tatttttatg
     4201 ttattggcct agagctacac gtatatgggt ttgtcctgag tccgttttca aatgaccttg
     4261 tgatagggaa atggttttgt ccatgttctt ggaaatactt gtgtatgtac agaaggaagg
     4321 gagggattat ttttctacaa agtaatttat gatttctaat tttctaatgt gccttggata
     4381 tgtgccaaat gatggaaaag aaacagtaaa ctttatgatt cttaaaaaaa aaaaaaaaaa
     4441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaag
     4501 g
//

LOCUS       NM_032236               4148 bp    mRNA    linear   PRI 26-JAN-2005
DEFINITION  Homo sapiens ubiquitin specific protease 48 (USP48), mRNA.
ACCESSION   NM_032236 NM_018391 NM_032759
VERSION     NM_032236.4  GI:52630448
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4148)
  AUTHORS   Quesada,V., D, Guti, Garabaya,C., Cal,S. and L.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem. Biophys. Res. Commun. 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   2  (bases 1 to 4148)
  AUTHORS   Puente,X.S., S, Overall,C.M. and L.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat. Rev. Genet. 4 (7), 544-558 (2003)
  MEDLINE   22722134
   PUBMED   12838346
REFERENCE   3  (bases 1 to 4148)
  AUTHORS   Wilkinson,K.D.
  TITLE     Regulation of ubiquitin-dependent processes by deubiquitinating
            enzymes
  JOURNAL   FASEB J. 11 (14), 1245-1256 (1997)
  MEDLINE   98072201
   PUBMED   9409543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067261.1, AF502942.1 and
            BF115822.1.
            On Sep 24, 2004 this sequence version replaced gi:18860906.
            
            Summary: This gene encodes a protein containing domains that
            associate it with the peptidase family C19, also known as family 2
            of ubiquitin carboxyl-terminal hydrolases. Family members function
            as deubiquitinating enzymes, recognizing and hydrolyzing the
            peptide bond at the C-terminal glycine of ubiquitin. Enzymes in
            peptidase family C19 are involved in the processing of
            poly-ubiquitin precursors as well as that of ubiquitinated
            proteins.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..4148
                     /gene="USP48"
                     /note="synonyms: USP31, RAP1GA1, MGC14879"
                     /db_xref="GeneID:84196"
     CDS             205..3312
                     /gene="USP48"
                     /note="ubiquitin specific protease 31;
                     go_function: ubiquitin thiolesterase activity [goid
                     0004221] [evidence IEA];
                     go_function: cysteine-type endopeptidase activity [goid
                     0004197] [evidence IEA];
                     go_process: ubiquitin cycle [goid 0006512] [evidence IEA];
                     go_process: protein modification [goid 0006464] [evidence
                     IEA];
                     go_process: ubiquitin-dependent protein catabolism [goid
                     0006511] [evidence IEA]"
                     /codon_start=1
                     /product="ubiquitin specific protease 48"
                     /protein_id="NP_115612.4"
                     /db_xref="GI:52630449"
                     /db_xref="GeneID:84196"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCKGNPNCLVGIGEHIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNIVQQQFCGEYA
                     YVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEFLKEEKLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEPYVEHKGGSY
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAE
                     PSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEKPNTTVQVPAFLQELVDRDNSKFEEW
                     CIEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPID
                     NHACLCSHDKLHPDKISIMKRISEYAADIFYSRYGGGPRLTVKALCKECVVERCRILR
                     LKNQLNEDYKTVNNLLKAAVKGSDGFWVGKSSLRSWRQLALEQLDEQDGDAEQSNGKM
                     NGSTLNKDESKEERKEEEELNFNEDILCPHGELCISENERRLVSKEAWSKLQQYFPKA
                     PEFPSYKECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDTD
                     VLYIVSQFFVEEWRKFVRKPTRCSPVSSVGNSALLCPHGGLMFTFASMTKEDSKLIAL
                     IWPSEWQMIQKLFVVDHVIKITRIEVGDVNPSETQYISEPKLCPECREGLLCQQQRDL
                     REYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGGT
                     KRQKISHQNYIAYQKQVIRRSMRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPFD
                     QNLSIDGKILSDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKGT
                     GLLGH"
     polyA_signal    3475..3480
                     /gene="USP48"
     polyA_site      3505
                     /gene="USP48"
                     /evidence=experimental
     polyA_signal    3801..3806
                     /gene="USP48"
     polyA_site      3826
                     /gene="USP48"
                     /evidence=experimental
     polyA_signal    4112..4117
                     /gene="USP48"
     polyA_site      4135
                     /gene="USP48"
ORIGIN      
        1 cggcggcgct ttgcggccgg tcgtgcgggt cgggcgcggg cgggcgcggc ggcagtggcg
       61 cgcacaggtg attgactggc cagctgcctg aaggagcgcc aggtcctcct tgctggcagg
      121 tggcgaagcc cattggggcg gcggtgcaga ccgcggcggc ggctgcggcg gtctggctcg
      181 ggaggcgttc ctggggccaa ggccatggcc ccgcggctgc agctggagaa ggcggcctgg
      241 cgctgggcgg agacggtgcg gcccgaggag gtgtcgcagg agcacatcga gaccgcttac
      301 cgcatctggc tggagccctg cattcgcggc gtgtgcagac gaaactgcaa aggaaatccg
      361 aattgcttgg ttggtattgg tgagcatatt tggttaggag aaatagatga aaatagtttt
      421 cataacatcg atgatcccaa ctgtgagagg agaaaaaaga actcatttgt gggcctgact
      481 aaccttggag ccacttgtta tgtcaacaca tttcttcaag tgtggtttct caacttggag
      541 cttcggcagg cactctactt atgtccaagc acttgtagtg actacatgct gggagacggc
      601 atccaagaag aaaaagatta tgagcctcaa acaatttgtg agcatctcca gtacttgttt
      661 gccttgttgc aaaacagtaa taggcgatac attgatccat caggatttgt taaagccttg
      721 ggcctggaca ctggacaaca gcaggatgct caagaatttt caaagctctt tatgtctcta
      781 ttggaagata ctttgtctaa acaaaagaat ccagatgtgc gcaatattgt tcaacagcag
      841 ttctgtggag aatatgccta tgtaactgtt tgcaaccagt gtggcagaga gtctaagctt
      901 ttgtcaaaat tttatgagct ggagttaaat atccaaggcc acaaacagtt aacagattgt
      961 atctcggaat ttttgaagga agaaaaatta gaaggagaca atcgctattt ttgcgagaac
     1021 tgtcaaagca aacagaatgc aacaagaaag attcgacttc ttagccttcc ttgcactctg
     1081 aacttgcagc taatgcgttt tgtctttgac aggcaaactg gacataagaa aaagctgaat
     1141 acctacattg gcttctcaga aattttggat atggagcctt atgtggaaca taaaggtggg
     1201 tcctacgtgt atgaactcag cgcagtcctc atacacagag gagtgagtgc ttattctggc
     1261 cactacatcg cccacgtgaa agatccacag tctggtgaat ggtataagtt taatgatgaa
     1321 gacatagaaa agatggaggg gaagaaatta caactaggga ttgaggaaga tctagcagaa
     1381 ccttctaagt ctcagacacg taaacccaag tgtggcaaag gaactcattg ctctcgaaat
     1441 gcatatatgt tggtttatag actgcaaact caagaaaagc ccaacactac tgttcaagtt
     1501 ccagcctttc ttcaagagct ggtagatcgg gataattcca aatttgagga gtggtgtatt
     1561 gaaatggctg agatgcgtaa gcaaagtgtg gataaaggaa aagcaaaaca cgaagaggtt
     1621 aaggagctgt accaaaggtt acctgctgga gctgagccct atgagtttgt ctctctggaa
     1681 tggctgcaaa agtggttgga tgaatcaaca cctaccaaac ctattgataa tcacgcttgc
     1741 ctgtgttccc atgacaagct tcacccggat aaaatatcaa ttatgaagag gatatctgaa
     1801 tatgcagctg acattttcta tagtagatat ggaggaggtc caagactaac tgtgaaagcc
     1861 ctgtgtaagg aatgtgtagt agaacgttgt cgcatattgc gtctgaagaa ccaactaaat
     1921 gaagattata aaactgttaa taatctgctg aaagcagcag taaagggcag cgatggattt
     1981 tgggtgggga agtcctcctt gcggagttgg cgccagctag ctcttgaaca gctggatgag
     2041 caagatggtg atgcagaaca aagcaacgga aagatgaacg gtagcacctt aaataaagat
     2101 gaatcaaagg aagaaagaaa agaagaggag gaattaaatt ttaatgaaga tattctgtgt
     2161 ccacatggtg agttatgcat atctgaaaat gaaagaaggc ttgtttctaa agaggcttgg
     2221 agcaaactgc agcagtactt tccaaaggct cctgagtttc caagttacaa agagtgctgt
     2281 tcacagtgca agattttaga aagagaaggg gaagaaaatg aagccttaca taagatgatt
     2341 gcaaacgagc aaaagacttc tctcccaaat ttgttccagg ataaaaacag accgtgtctc
     2401 agtaactggc cagaggatac ggatgtcctc tacatcgtgt ctcagttctt tgtagaagag
     2461 tggcggaaat ttgttagaaa gcctacaaga tgcagccctg tgtcatcagt tgggaacagt
     2521 gctcttttgt gtccccacgg gggcctcatg tttacatttg cttccatgac caaagaagat
     2581 tctaaactta tagctctcat atggcccagt gagtggcaaa tgatacaaaa gctctttgtt
     2641 gtggatcatg taattaaaat cacgagaatt gaagtgggag atgtaaaccc ttcagaaaca
     2701 cagtatattt ctgagcccaa actctgtcca gaatgcagag aaggcttatt gtgtcagcag
     2761 cagagggacc tgcgtgaata cactcaagcc accatctatg tccataaagt tgtggataat
     2821 aaaaaggtga tgaaggattc ggctccggaa ctgaatgtga gtagttctga aacagaggag
     2881 gacaaggaag aagctaaacc agatggagaa aaagatccag attttaatca aagcaatggt
     2941 ggaacaaagc ggcaaaagat atcccatcaa aattatatag cctatcaaaa gcaagttatt
     3001 cgccgaagta tgcgacatag aaaagttcgt ggtgagaaag cacttctcgt ttctgctaat
     3061 cagacgttaa aagaattgaa aattcagatc atgcatgcat tttcagttgc tccttttgac
     3121 cagaatttgt caattgatgg aaagatttta agtgatgact gtgccaccct aggcaccctt
     3181 ggcgtcattc ctgaatctgt cattttattg aaggctgatg aaccaattgc agattatgct
     3241 gcaatggatg atgtcatgca agtttgtatg ccagaagaag ggtttaaagg tactggtctt
     3301 cttggacatt aatctttgaa tacttgctga ctgctaagaa atgaccagag gggaagagga
     3361 gtttgacatg ttagggcatt aaagcaaagg tggatttaag aattaaacca ttacatgccc
     3421 cttccaaaag gcagaaatcc attcaaacgt gactgtccca aatgccttat gtcaaataaa
     3481 gcagattgca ctgatggaca tcagacttga aggaaatgtt tccaatttta tatttaaggg
     3541 gggtggtggg tgggaggggg caagtaaaga cggaacaagt ttagtagcag taatagtaaa
     3601 tcatgtttac atatgagatt tatagtcgtg ggaggggaat aaagttctgt tatatttcct
     3661 tgctcgagtt tcataccaga tgcgttggtc cataaaggat tgtatcaagt agatgggaca
     3721 acattctgct ctgaacgaaa agtaatttta gagacataac ctgcttacca atgcctgtct
     3781 ttgattcata ttctactttc aataaagcat gaaagtgaag aacttgtcct aagtgtggaa
     3841 aagtgtcttc agatttagac tcttctccat gtcagctgca gcgccacccg ccttacacct
     3901 gcccggccgt ctgtctcttg gtattgggta aaggaggggg cacctgcatg tctcctgcaa
     3961 tgagcaagga attatgtctc atgttttgac ttcagaggct ttttgctttg gtgcatttca
     4021 gaaaggatgg agaacattta ttatgtgtga aagcatcctc ttccggtttt gctgttattc
     4081 aaaagtggga aatgtacctg gcacgtttga aaataaaaaa tctgactacc tatcaaaaaa
     4141 aaaaaaaa
//

LOCUS       NM_032367               1438 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens zinc finger, BED domain containing 3 (ZBED3), mRNA.
ACCESSION   NM_032367
VERSION     NM_032367.1  GI:14150184
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC007239.1.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..1438
                     /gene="ZBED3"
                     /note="synonym: MGC15435"
                     /db_xref="GeneID:84327"
     CDS             248..952
                     /gene="ZBED3"
                     /note="hypothetical protein MGC15435; 2610005H11Rik;
                     go_function: DNA binding [goid 0003677] [evidence IEA]"
                     /codon_start=1
                     /product="zinc finger, BED domain containing 3"
                     /protein_id="NP_115743.1"
                     /db_xref="GI:14150185"
                     /db_xref="GeneID:84327"
                     /translation="MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAP
                     YSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELE
                     SSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQG
                     ERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKD
                     DPEGDRDGCVITKVLL"
ORIGIN      
        1 ccgggacaaa atgtcagcga ggcgcctgga gggggatcta ccatctcgga ctcccgaccc
       61 gccgccggct ccggccgcgt ttcccgggta aagggcactg ctgatggttc ttcagaactc
      121 aggaatcgtg ttgcatgcat tgtttctacc cacctgagat ggttggaaac cctgaggcaa
      181 tgacagggac cccagaatcc ttgggaaatt acccactgtc taatttaaag cgtgcgggcg
      241 ccgcagaatg aggagtggcg agccggcctg caccatggac caggcccgcg ggctggacga
      301 cgcggcggcg cggggcggtc agtgtccggg actggggccg gcgccgacgc cgacgcctcc
      361 cggccgcctg ggggcgccat actccgaggc ctggggctac ttccacctgg cgccggggcg
      421 ccccgggcat ccgtcgggcc actgggccac ctgccgtctg tgcggggagc aggtgggccg
      481 cggcccgggc ttccacgcgg ggacctcggc gttgtggagg cacctgagga gcgcgcaccg
      541 gcgggagctg gagagcagcg gcgccgggag ctccccacct gccgcgccct gcccgccgcc
      601 gcccggcccc gctgcggccc ccgagggcga ctgggcgcgc ctgctggaac agatgggcgc
      661 gctggccgtg cgcggcagcc ggcgggagcg ggagctggag cggcgcgagc tggccgtgga
      721 gcagggcgag cgcgccctgg agcggaggcg gagggcgctg caggaggaag agcgcgccgc
      781 ggcccaggcg cgccgggaac tgcaggccga gcgggaggcg ctgcaggcgc ggctgcggga
      841 tgtgagccgc cgtgagggcg ccctgggctg ggcccccgct gcgccgccgc cgctcaagga
      901 cgaccccgag ggtgacaggg acggctgcgt catcacaaag gtcctcctgt aggggtgtgg
      961 ccacttcccc accccaggac agcgcttctc cgtccaatgc caatgccttc agaccccgct
     1021 gggaccgaag ccgtaaccga agccaggccc gcagccgcta ctcactcgga agctccagct
     1081 aactgtagga tcttccacac cctaaggctt cagcttgaga agcacttcga agccagagca
     1141 gaaccaaaac tcacttccat ggggtcaccg ggggtgcctg ggcggccttt cgtgggcatg
     1201 cacgcaagga attggggtgg cacacgggac acccgagagc tccaggagcc ccgtgaaccc
     1261 agaccaccca gtgccatggc cacttagggc tgggaacccg aacctggtga ctttgaaagg
     1321 atagagcttc attccatacc aaagacttat cacaccatgt gcctatacac ccagcagccc
     1381 aaggtggagg gtgcgtggaa atgagaaagc tttttacccc aaaaaaaaaa aaaaaaaa
//

LOCUS       NM_032525               1843 bp    mRNA    linear   PRI 14-DEC-2004
DEFINITION  Homo sapiens tubulin, beta 6 (TUBB6), mRNA.
ACCESSION   NM_032525
VERSION     NM_032525.1  GI:14210535
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC002654.1.
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..1843
                     /gene="TUBB6"
                     /note="synonyms: TUBB-5, HsT1601, MGC4083"
                     /db_xref="GeneID:84617"
     CDS             46..1386
                     /gene="TUBB6"
                     /note="tubulin beta MGC4083;
                     go_component: tubulin [goid 0045298] [evidence IEA];
                     go_function: GTP binding [goid 0005525] [evidence IEA];
                     go_function: GTPase activity [goid 0003924] [evidence
                     IEA];
                     go_function: structural molecule activity [goid 0005198]
                     [evidence IEA];
                     go_process: microtubule polymerization [goid 0046785]
                     [evidence IEA];
                     go_process: microtubule-based movement [goid 0007018]
                     [evidence IEA]"
                     /codon_start=1
                     /product="tubulin, beta 6"
                     /protein_id="NP_115914.1"
                     /db_xref="GI:14210536"
                     /db_xref="GeneID:84617"
                     /translation="MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQL
                     ERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWA
                     KGHYTEGAELVDAVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFP
                     DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQ
                     SKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRK
                     AFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATANDGEEAFEDEEEEIDG"
ORIGIN      
        1 gggcacgagg gcagagccag ttcctagcgc agagccgcgc ccgccatgag ggagatcgtg
       61 cacatccagg cgggccagtg cgggaaccag atcggcacca agttttggga agtgatcagc
      121 gatgagcacg gcatcgaccc ggccggaggc tacgtgggag actcggcgct gcagctggag
      181 agaatcaacg tctactacaa tgagtcatcg tctcagaaat atgtgcccag ggccgccctg
      241 gtggacttag agccaggcac catggacagc gtgcggtctg ggccttttgg gcagcttttc
      301 cggcctgaca acttcatctt tggccagacg ggtgcaggga acaactgggc gaaagggcac
      361 tacacggagg gcgcggagct ggtggacgca gtgctggacg tggtgcggaa ggagtgcgag
      421 cactgcgact gcctgcaggg cttccagctc acgcactcgc tgggcggcgg cacgggctca
      481 ggcatgggca cgctgctcat cagcaagatc cgtgaggagt tcccggaccg catcatgaac
      541 accttcagcg tcatgccctc gcccaaggtg tcggacacgg tggtggagcc ctacaatgcc
      601 acactgtcgg tgcaccagct ggtggagaat acagacgaga cctactgcat cgacaacgag
      661 gcgctctatg acatctgctt ccgcactctg aagctgacaa cgcccaccta cggggacctc
      721 aaccacctgg tgtccgccac catgagtggg gtcaccacct cgctgcgctt cccgggccag
      781 ctcaatgctg acctgcgcaa gctggcggtg aacatggtgc ccttcccgcg cctgcacttc
      841 ttcatgcctg gcttcgcgcc gctcaccagc cgcggcagcc agcagtaccg ggccctgacc
      901 gtgcccgagc tcacccagca gatgttcgac gccaggaaca tgatggccgc ctgcgatccg
      961 cgccatggcc gctacctgac cgtggccacc gtgttccgcg ggcccatgtc catgaaggag
     1021 gtggacgagc agatgctggc catccagagt aagaacagca gctacttcgt ggagtggatt
     1081 cccaacaacg tgaaggtggc cgtgtgcgac atcccgcccc gcggcctgaa gatggcctcc
     1141 accttcatcg gcaacagcac ggccatccag gagctgttca agcgcatctc cgagcagttc
     1201 tcagccatgt tccggcgcaa ggccttcctg cactggttca cgggtgaggg catggatgaa
     1261 atggagttca ccgaggcgga gagcaacatg aacgacctgg tatccgagta ccagcagtac
     1321 caggatgcca ccgccaatga cggggaggaa gcttttgagg atgaggaaga ggagatcgat
     1381 ggatagtcgg aatagagccg ccccaactca gatcctacaa cacgcaagtt ccttcttgaa
     1441 ccctggtgcc tcctacccta tggccctgaa tggtgcactg gtttaattgt gttggtgtcg
     1501 gcccctcaca aatgcagcca agtcatgtaa ttagtcatct ggaacaaaga ctaaaaacag
     1561 cagagaattg cgggttctac ccagtcagaa gatcacacca tggagacttt ctactagagg
     1621 acttgaaaga gaactgaggg gccacaaaat aaacttcacc ttccattaag tgttcaagca
     1681 tgtctgcaaa ttaggaggga gttagaaaca gtctttttca tcctttgtga tgaagcctga
     1741 aattgtgccg tgttgcctta tatgaatatg cagtatggga ctttgaaata atgattcata
     1801 ataaaatact aaacgtgtgt cttcaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_033116               3244 bp    mRNA    linear   PRI 18-DEC-2004
DEFINITION  Homo sapiens NIMA (never in mitosis gene a)- related kinase 9
            (NEK9), mRNA.
ACCESSION   NM_033116
VERSION     NM_033116.3  GI:31543285
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Tan,B.C. and Lee,S.C.
  TITLE     Nek9, a novel FACT-associated protein, modulates interphase
            progression
  JOURNAL   J. Biol. Chem. 279 (10), 9321-9330 (2004)
   PUBMED   14660563
  REMARK    GeneRIF: mediates certain cellular processes, which are ultimately
            essential for interphase progression
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Belham,C., Roig,J., Caldwell,J.A., Aoyama,Y., Kemp,B.E., Comb,M.
            and Avruch,J.
  TITLE     A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the
            Nek6 and Nek7 kinases
  JOURNAL   J. Biol. Chem. 278 (37), 34897-34909 (2003)
  MEDLINE   22841161
   PUBMED   12840024
  REMARK    GeneRIF: Activated in mitosis, and activates nek6 and nek7 kinase.
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Roig,J., Mikhailov,A., Belham,C. and Avruch,J.
  TITLE     Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and
            regulates mitotic progression
  JOURNAL   Genes Dev. 16 (13), 1640-1658 (2002)
  MEDLINE   22095334
   PUBMED   12101123
  REMARK    GeneRIF: binds the Ran GTPase and regulates mitotic progression
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Holland,P.M., Milne,A., Garka,K., Johnson,R.S., Willis,C.,
            Sims,J.E., Rauch,C.T., Bird,T.A. and Virca,G.D.
  TITLE     Purification, cloning, and characterization of Nek8, a novel
            NIMA-related kinase, and its candidate substrate Bicd2
  JOURNAL   J. Biol. Chem. 277 (18), 16229-16240 (2002)
  MEDLINE   21975258
   PUBMED   11864968
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Ohara,O., Nagase,T., Mitsui,G., Kohga,H., Kikuno,R., Hiraoka,S.,
            Takahashi,Y., Kitajima,S., Saga,Y. and Koseki,H.
  TITLE     Characterization of size-fractionated cDNA libraries generated by
            the in vitro recombination-assisted method
  JOURNAL   DNA Res. 9 (2), 47-57 (2002)
  MEDLINE   22051173
   PUBMED   12056414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY080896.1.
            On Jun 9, 2003 this sequence version replaced gi:19311015.
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3244
                     /gene="NEK9"
                     /note="synonyms: Nek8, NERCC, NERCC1, MGC16714,
                     DKFZp434D0935"
                     /db_xref="GeneID:91754"
     CDS             13..2952
                     /gene="NEK9"
                     /note="NIMA-related kinase Nek8; This gene is predicted by
                     Genscan and supported by ESTs AA836348 and AI077817.  The
                     closest BLAST X similarity is to serine/threonine-protein
                     kinase;
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: magnesium ion binding [goid 0000287]
                     [evidence IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence IEA];
                     go_process: mitosis [goid 0007067] [evidence IEA];
                     go_process: cell cycle [goid 0007049] [evidence IEA];
                     go_process: cytokinesis [goid 0000910] [evidence IEA];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence IEA]"
                     /codon_start=1
                     /product="NIMA related kinase 9"
                     /protein_id="NP_149107.3"
                     /db_xref="GI:31543286"
                     /db_xref="GeneID:91754"
                     /translation="MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGA
                     AEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVI
                     LALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQI
                     VSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYM
                     SPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQ
                     YSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTV
                     TEAPIAVVTSRTSEVYIWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYT
                     WVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAF
                     GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE
                     YGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGL
                     NQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN
                     KCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL
                     AMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSNSSGL
                     SIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAM
                     GNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASE
                     APLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQ
                     KLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKPDLDSDSGCLLGT
                     DSCRPSL"
ORIGIN      
        1 gcggccgccg ccatgtcggt gctgggcgag tacgagcgac actgcgattc catcaactcg
       61 gactttggga gcgagtccgg gggttgcggg gactcgagtc cggggcctag cgccagtcag
      121 gggccgcgag ccggcggcgg cgcggcggag caggaggaac tgcactacat ccccatccgc
      181 gtcctgggcc gcggcgcctt cggggaagcc acgctgtacc gccgcaccga ggatgactca
      241 ctggttgtgt ggaaggaagt cgatttgacc cggctgtctg agaaggaacg tcgtgatgcc
      301 ttgaatgaga tagttattct ggcactgctg cagcacgaca acattattgc ctactacaat
      361 cacttcatgg acaataccac gctgctgatt gagctggaat attgtaatgg agggaacctg
      421 tatgacaaaa tccttcgtca gaaggacaag ttgtttgagg aagagatggt ggtgtggtac
      481 ctatttcaga ttgtttcagc agtgagctgc atccataaag ctggaatcct tcatagagat
      541 ataaagacat taaatatttt tctgaccaag gcaaacctga taaaacttgg agattatggc
      601 ctagcaaaga aacttaattc tgagtattcc atggctgaga cgcttgtggg aaccccatat
      661 tacatgtctc cagagctctg tcaaggagta aagtacaatt tcaagtctga tatctgggca
      721 gttggctgcg tcatttttga actgcttacc ttaaagagga cgtttgatgc tacaaaccca
      781 cttaacctgt gtgtgaagat cgtgcaagga attcgggcca tggaagttga ctctagccag
      841 tactctttgg aattgatcca aatggttcat tcgtgccttg accaggatcc tgagcagaga
      901 cctactgcag atgaacttct agatcgccct cttctcagga aacgcaggag agagatggag
      961 gaaaaagtca ctctgcttaa tgcacctaca aagagaccaa ggtcaagcac tgtgactgaa
     1021 gcacccattg ctgtagtaac atcacgaacc agtgaagtct atatttgggg tggtggaaaa
     1081 tccacccccc agaaactgga tgttatcaag agtggctgta gtgcccggca ggtctgtgca
     1141 gggaataccc actttgctgt ggtcacagtg gagaaggaac tgtacacttg ggtgaacatg
     1201 caaggaggca ctaaactcca tggtcagctg ggccatggag acaaagcctc ctatcgacag
     1261 ccaaagcatg tggaaaagtt gcaaggcaaa gctatccatc aggtgtcatg tggtgatgat
     1321 ttcactgtct gtgtgactga tgagggtcag ctctatgcct tcggatcaga ttattatggc
     1381 tgcatggggg tggacaaagt tgctggccct gaagtgctag aacccatgca gctgaacttc
     1441 ttcctcagca atccagtgga gcaggtctcc tgtggagata atcatgtggt ggttctgaca
     1501 cgaaacaagg aagtctattc ttggggctgt ggcgaatatg gacgactggg tttggattca
     1561 gaagaggatt attatacacc acaaaaggtg gatgttccca aggccttgat tattgttgca
     1621 gttcaatgtg gctgtgatgg gacatttctg ttgacccagt caggcaaagt gctggcctgt
     1681 ggactcaatg aattcaataa gctgggtctg aatcagtgca tgtcgggaat tatcaaccat
     1741 gaagcatacc atgaagttcc ctacacaacg tcctttacct tggccaaaca gttgtccttt
     1801 tataagatcc gtaccattgc cccaggcaag actcacacag ctgctattga tgagcgaggc
     1861 cggctgctga cctttggctg caacaagtgt gggcagctgg gcgttgggaa ctacaagaag
     1921 cgtctgggaa tcaacctgtt ggggggaccc cttggtggga agcaagtgat cagggtctcc
     1981 tgcggtgatg agtttaccat tgctgccact gatgataatc acatttttgc ctggggcaat
     2041 ggtggtaatg gccgcctggc aatgaccccc acagagagac cacatggctc tgatatctgt
     2101 acctcatggc ctcggcctat ttttggatct ctgcatcatg tcccggacct gtcttgccgt
     2161 ggatggcata ccattctcat cgttgagaaa gtattgaatt ctaagaccat ccgttccaat
     2221 agcagtggct tatccattgg aactgtgttt cagagctcta gcccgggagg aggcggcggg
     2281 ggcggcggtg gtgaagaaga ggacagtcag caggaatctg aaactcctga cccaagtgga
     2341 ggcttccgag gaacaatgga agcagaccga ggaatggaag gtttaatcag tcccacagag
     2401 gccatgggga acagtaatgg ggccagcagc tcctgtcctg gctggcttcg aaaggagctg
     2461 gaaaatgcag aatttatccc catgcctgac agcccatctc ctctcagtgc agcgttttca
     2521 gaatctgaga aagataccct gccctatgaa gagctgcaag gactcaaagt ggcctctgaa
     2581 gctcctttgg aacacaaacc ccaagtagaa gcctcgtcac ctcggctgaa tcctgcagta
     2641 acctgtgctg ggaagggaac accactgact cctcctgcgt gtgcgtgcag ctctctgcag
     2701 gtggaggttg agagattgca gggtctggtg ttaaagtgtc tggctgaaca acagaagcta
     2761 cagcaagaaa acctccagat ttttacccaa ctgcagaagt tgaacaagaa attagaagga
     2821 gggcagcagg tggggatgca ttccaaagga actcagacag caaaggaaga gatggaaatg
     2881 gatccaaagc ctgacttaga ttcagattcc gggtgcctcc tgggaacaga ctcctgtaga
     2941 cccagcctct agtctcctga gcctatagag cccccaggag actgggaccc aaagaacttc
     3001 acagcacact taccgaatgc agagagcagc tttcctggct ttgttcactt gcagaaaagg
     3061 agcgcaaggc agaggctctg aagcactttc cttgtacatt tggagagtgg cattgccttt
     3121 tagataggat ctaggagtga ttttattgtt ttggagaatg gaagggcccc catggccctg
     3181 gctttgtcat cagtgactgc catagcaaca gcagctctgt acctcatctg ttgatcccac
     3241 cttt
//

LOCUS       NM_033332               4968 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens CDC14 cell division cycle 14 homolog B (S. cerevisiae)
            (CDC14B), transcript variant 3, mRNA.
ACCESSION   NM_033332
VERSION     NM_033332.1  GI:15451937
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Li,L., Ljungman,M. and Dixon,J.E.
  TITLE     The human Cdc14 phosphatases interact with and dephosphorylate the
            tumor suppressor protein p53
  JOURNAL   J. Biol. Chem. 275 (4), 2410-2414 (2000)
   PUBMED   10644693
REFERENCE   2  (bases 1 to 4968)
  AUTHORS   Li,L., Ernsting,B.R., Wishart,M.J., Lohse,D.L. and Dixon,J.E.
  TITLE     A family of putative tumor suppressors is structurally and
            functionally conserved in humans and yeast
  JOURNAL   J. Biol. Chem. 272 (47), 29403-29406 (1997)
   PUBMED   9367992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF064105.2.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein tyrosine phosphatase family. This protein is
            highly similar to Saccharomyces cerevisiae Cdc14, a protein
            tyrosine phosphatase involved in the exit of cell mitosis and
            initiation of DNA replication, which suggests the role in cell
            cycle control. This protein has been shown to interact with and
            dephosphorylates tumor suppressor protein p53, and is thought to
            regulate the function of p53. Alternative splice of this gene
            results in 3 transcript variants encoding distinct isoforms.
            
            Transcript Variant: This variant (3) contains a distinct 3' region
            including a part of the coding sequence and the entire 3' UTR
            sequence, as compared to variant 1. The isoform (3) encoded by this
            variant lacks the last 11 aa and contains additional 23 aa at the
            C-terminus, as compared to isoform 1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..4968
                     /gene="CDC14B"
                     /note="synonyms: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B"
                     /db_xref="GeneID:8555"
                     /db_xref="MIM:603505"
     CDS             453..1868
                     /gene="CDC14B"
                     /note="isoform 3 is encoded by transcript variant 3; CDC14
                     (cell division cycle 14, S. cerevisiae) homolog B;
                     go_component: nucleus [goid 0005634] [evidence IDA] [pmid
                     9367992];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: protein tyrosine phosphatase activity [goid
                     0004725] [evidence IEA];
                     go_function: protein tyrosine phosphatase activity [goid
                     0004725] [evidence IDA] [pmid 9367992];
                     go_function: protein serine/threonine phosphatase activity
                     [goid 0004722] [evidence IDA] [pmid 9367992];
                     go_function: protein tyrosine/serine/threonine phosphatase
                     activity [goid 0008138] [evidence IEA];
                     go_process: cytokinesis [goid 0000910] [evidence IEA];
                     go_process: protein amino acid dephosphorylation [goid
                     0006470] [evidence IEA];
                     go_process: protein amino acid dephosphorylation [goid
                     0006470] [evidence NAS] [pmid 9367992]"
                     /codon_start=1
                     /product="CDC14 homolog B isoform 3"
                     /protein_id="NP_201589.1"
                     /db_xref="GI:15451938"
                     /db_xref="GeneID:8555"
                     /db_xref="MIM:603505"
                     /translation="MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDPRRRDP
                     QDDVYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCC
                     KINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGET
                     SYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNW
                     IIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDA
                     GFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYR
                     MTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSK
                     LLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTDG
                     WLSQAVTFLDRLLIWLGIHKD"
     misc_feature    1796..4968
                     /gene="CDC14B"
                     /note="Region: the region different from variant 1"
     polyA_signal    4940..4945
                     /gene="CDC14B"
     polyA_site      4960
                     /gene="CDC14B"
ORIGIN      
        1 cacggaacag ccctcctggg gtccccacga gccgcgtcct gctgtgcccc ggcgcctacg
       61 cagcagcggc cgcggccgcg gtgggcacgc acggttaccc cgggcagctc cggccgccag
      121 ctgcagcccc gtcgcctcgg ccgcgccagc cggctgcggg cacctggggg cgggctgggg
      181 gcgccggccg cggcaggagg cgctgtagcg agggctgcgg cgccggtcct gcggcggccg
      241 cgggaggcag cggggcaggc gctgtgggcc gggctcctcc tccggctcct gcgcgaccgc
      301 ctcccgccgg gctctgccgg cgcccgccgt ccccgcagcg ccgctctgcg cccgccgccc
      361 cgagcgcccg cgcggggctg gcgggagcct cggcgggcgc gcgggcgcgc ggggccatgg
      421 tcgtggcccc ctgacgggcc gcggccgcct ccatgaagcg gaaaagcgag cggcggtcga
      481 gctgggccgc cgcgcccccc tgctcgcggc gctgctcgtc gacctcgccg ggtgtgaaga
      541 agatccgcag ctccacgcag caagacccgc gccgccggga cccccaggac gacgtgtacc
      601 tggacatcac cgatcgcctt tgttttgcca ttctctacag cagaccaaag agtgcatcaa
      661 atgtacatta tttcagcata gataatgaac ttgaatatga gaacttctac gcagattttg
      721 gaccactcaa tctggcaatg gtttacagat attgttgcaa gatcaataag aaattaaagt
      781 ccattacaat gttaaggaag aaaattgttc attttactgg ctctgatcag agaaaacaag
      841 caaatgctgc cttccttgtt ggatgctaca tggttatata tttggggaga accccagaag
      901 aagcatatag aatattaatc tttggagaga catcctatat tcctttcaga gatgctgcct
      961 atggaagttg caatttctac attacacttc ttgactgttt tcatgcagta aagaaggcaa
     1021 tgcagtatgg cttccttaat ttcaactcat ttaaccttga tgaatatgaa cactatgaaa
     1081 aagcagaaaa tggagattta aattggataa taccagaccg atttattgcc ttctgtggac
     1141 ctcattcaag agccagactt gaaagtggtt accaccaaca ttctcctgag acttatattc
     1201 aatattttaa gaatcacaat gttactacca ttattcgtct gaataaaagg atgtatgatg
     1261 ccaaacgctt tacggatgct ggcttcgatc accatgatct tttctttgcg gatggcagca
     1321 cccctactga tgccattgtc aaagaattcc tagatatctg tgaaaatgct gagggtgcca
     1381 ttgcagtaca ttgcaaagct ggccttggtc gcacgggcac tctgatagcc tgctacatca
     1441 tgaagcatta caggatgaca gcagccgaga ccattgcgtg ggtcaggatc tgcagacctg
     1501 gctcggtgat tgggcctcag cagcagtttt tggtgatgaa gcaaaccaac ctctggctgg
     1561 aaggggacta ttttcgtcag aagttaaagg ggcaggagaa tggacaacac agagcagcct
     1621 tctccaaact tctctctggc gttgatgaca tttccataaa tggggtcgag aatcaagatc
     1681 agcaagaacc cgaaccgtac agtgatgatg acgaaatcaa tggagtgaca caaggtgata
     1741 gacttcgggc cttgaaaagc agaagacaat ccaaaacaaa cgctattcct ctcaccgatg
     1801 gttggctgtc ccaggctgtc acctttctag accggcttct gatctggctc gggatccaca
     1861 aggactagac ctgcggggaa ggtctctcct ggacacgccc gttgcccact gcaagttctc
     1921 tccaggtgca attgaagcct ctcagcagcg gaggccgcca tgtggagaga gcaggcaggc
     1981 ccactgctgc tgagaacagg gcaggcacgg gcagctcctg ttctgccttt cccagcttcg
     2041 gagacgcagg ctcagctgct ccgaagcacc tgccagcacc gcacagtaca gtttcagagg
     2101 acagcagtct ccttcccgtg aagctcccat gtgctggaat ggcatggact tgctgatcaa
     2161 cagaaggaaa tggtctgaag tctgaccagc acaaggaagg aggctggctg gctcagaggg
     2221 gcccaccttg cgtggaatga aaacgccaaa ggctcatgag caacattagg ctagaggggt
     2281 cttgttcaaa gcatccaact ctgacttcgg aggcattccc agccggcagc agtgtgtcca
     2341 gcctgcctct tcccaggctg gtctgacatg cagcttaggc tttcatccca agttaggtac
     2401 tgacccctcc ctcttgggca gcacctccct ttttaaaaaa attttttttt cttccaaaga
     2461 cagagtcttg ctcttgttgt ccaggctgga gtgcagtggc gcgatctagg ctcactgcaa
     2521 cctccttctc ccaggttcaa gcgactctcc tgcctcagcc tcctgagtag ctgggattat
     2581 aggcgtctgc caccacgccc ggctaatttc tgtattttta gtagagacag ggtttcacca
     2641 tgttggccag gctggtctcg aactcctgac ctcaagtgat ctgcctgcct tggcctccca
     2701 aagtgctggg attacaggtg tcagccaccg cacccagcca agcaccccta tctctagagg
     2761 atctggcccc ccagcccagt tactgcaggg cagctttccc cacctggtga caggctgtgc
     2821 gcagcagccc caggacctca ccctgagctg agtcttcagg agccgccctg gtggcacaac
     2881 tcagacaccc ctgaggccta gcagtcaact cctgattcag acatgatcca gtccagcctg
     2941 ggcttggcta taaccagctc aaacttgctt gacctccact tttcaggaga cttggggacg
     3001 acagccctca tcggcgtctt tcatggggtt aatctgcttg agtctaagtc gccagccaga
     3061 aacgtggtgc ccagggtgcc ctgcctcagg acatgtccac acccacgtca caagcacctg
     3121 aggagtccgg ccggggcact gtggtccaaa aggtcctgcc gcctccgcat ctgactgtcc
     3181 caacggcatg ctggtgacac ccccctgccc ttcgcttctg tcctccctgg cttctctggg
     3241 gcacttgggg ctatgtacaa cctggcacga tccagaaagg gtgcaaacaa aatgcctaca
     3301 tccaggcaca cgaccaagtc agcgagagct agccctggta agcaaacata gcccattaca
     3361 ggttcagaac gtgcaccggg ttccccaaaa ctgtcttcaa ccacatgact caacagctct
     3421 atgggatagg aactgtcagt gtttttgcaa ctgcaacatt aaaccaagtg ctgtgggctt
     3481 ttcaagtatt attcacaaca ctaaaggaaa gtttcttcaa agggctctct ggctaatctt
     3541 caaagccgca gttaggcaaa atgacagtgt gacagcttca aagccactga ctcatgacac
     3601 agccctgatg ttgtaccggc taggttcaga tttcagaaat cagggcactt gcatccattg
     3661 ccttttccag gaaagggaag aaaacactca gttgataaac cttagtactc agataataaa
     3721 taagagacca aaagtaggct atcacccaaa gcaaacatcc ttaactgacc ctaacgtgta
     3781 tggattcaac tttgattatt caacaaaatc atgaccgact gctgtggcct ggagtaacca
     3841 aaggactgtt ttctctacac aaagtcagga gcgaatacca acctttattt gcacttgggt
     3901 tccagttcaa agccacctta gacagtgtgg caaagtggga aaaagcacag atcctgggac
     3961 caaggttcag attccatctc aagcgagcat atgaactgtg tgacaacagg cagacagtac
     4021 ctctgtgtct atgagaaagc ggggagagca acaccccagc ttctagcagc tctacagctg
     4081 cctggacctg caggccctcc taggcccact tcctccccag cacagtgtgt gttcccgggc
     4141 gtgtgtggct ctgggtccag ctctgttcag ggtgggactc caggtgaatt actgaacctc
     4201 tgaggtgtac ccccaacccc aaactttcac caaaagcaat aaagaggaac tctagaactg
     4261 gagccaggac taagtgagaa aaactgctta taagtgctta ataaatacta gttatttaca
     4321 acttttgctc aagccgaggg cagaggcctt tgtacgcagc tgccgaactc tgactctagt
     4381 tctgcggaag aaaaggatgc ggtatttgct tttgccatga tccctttcca tttgattggc
     4441 aggttaaata acatggtttt tgaagtcaca tacttaatat tcttcctaaa aaccacccaa
     4501 acactagatg tgtgtgtgca cacacacaga aaccacgagg tagtttaaat caccattaaa
     4561 aatcaacgct ttctctgatt ctgtgtcaca gagtggtggc cagtggctac acaatagcga
     4621 tttttaaatg attggttaag tgaaaaccag aactcaaaat attccaggag agaagataac
     4681 atttacaagt aaacagtaag tgcaattgta ttttaatttc ttggtctccg aaaactcagc
     4741 tgtgactgct ttccattaac agttccagct ctatgtgttt cctctaacgc taaaggcaca
     4801 gcccccggga atctactgct tcctaagagt ctccatggag tctattttac aacctccttt
     4861 ccctccatgc ttccgcggag gagtctatac tatctctata tacacatttt aaacattatt
     4921 cttcatttga aattccttca ataaaaacac agtcaccatt aaaaaaaa
//

LOCUS       NM_057175               5554 bp    mRNA    linear   PRI 10-DEC-2004
DEFINITION  Homo sapiens NMDA receptor regulated 1 (NARG1), mRNA.
ACCESSION   NM_057175 NM_025085
VERSION     NM_057175.3  GI:56549647
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5554)
  AUTHORS   Willis,D.M., Loewy,A.P., Charlton-Kachigian,N., Shao,J.S.,
            Ornitz,D.M. and Towler,D.A.
  TITLE     Regulation of osteocalcin gene expression by a novel Ku antigen
            transcription factor complex
  JOURNAL   J. Biol. Chem. 277 (40), 37280-37291 (2002)
  MEDLINE   22241900
   PUBMED   12145306
REFERENCE   2  (bases 1 to 5554)
  AUTHORS   Fluge,O., Bruland,O., Akslen,L.A., Varhaug,J.E. and Lillehaug,J.R.
  TITLE     NATH, a novel gene overexpressed in papillary thyroid carcinomas
  JOURNAL   Oncogene 21 (33), 5056-5068 (2002)
  MEDLINE   22136178
   PUBMED   12140756
  REMARK    GeneRIF: NATH, a novel gene overexpressed in papillary thyroid
            carcinomas.
REFERENCE   3  (bases 1 to 5554)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br. J. Cancer 86 (11), 1824-1830 (2002)
  MEDLINE   22081493
   PUBMED   12087473
REFERENCE   4  (bases 1 to 5554)
  AUTHORS   Choi,S.C., Chang,J.Y. and Han,J.K.
  TITLE     A novel Xenopus acetyltransferase with a dynamic expression in
            early development
  JOURNAL   Biochem. Biophys. Res. Commun. 285 (5), 1338-1343 (2001)
  MEDLINE   21371756
   PUBMED   11478804
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BC032642.1, AC097376.3,
            AY039242.1 and AY112670.1.
            On or before Dec 10, 2004 this sequence version replaced
            gi:17149826, gi:22219474.
            
            Summary: This gene encodes a protein of unknown function. However,
            similarity to proteins in yeast and other species suggests that
            this protein may be an N-acetyltransferase.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..5554
                     /gene="NARG1"
                     /note="synonyms: Ga19, NATH, TBDN100"
                     /db_xref="GeneID:80155"
                     /db_xref="MIM:608000"
     CDS             257..2857
                     /gene="NARG1"
                     /note="putative N-acetyltransferase; gastric cancer
                     antigen Ga19; transcriptional coactivator tubedown-100;
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: transcription factor activity [goid 0003700]
                     [evidence IEA];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="NMDA receptor regulated 1"
                     /protein_id="NP_476516.1"
                     /db_xref="GI:17149828"
                     /db_xref="GeneID:80155"
                     /db_xref="MIM:608000"
                     /translation="MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAE
                     HGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKC
                     YRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHL
                     LEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEK
                     QICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLER
                     LKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYK
                     DKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSI
                     ALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAK
                     YMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKC
                     HEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYL
                     KLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQ
                     KKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIY
                     FRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNR
                     LFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRN
                     LQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSS
                     AEAEELANEI"
     polyA_signal    5050..5055
                     /gene="NARG1"
     polyA_site      5078
                     /gene="NARG1"
                     /evidence=experimental
     polyA_site      5409
                     /gene="NARG1"
                     /evidence=experimental
     polyA_signal    5538..5543
                     /gene="NARG1"
ORIGIN      
        1 tgttcagtta ccacgtgaac cgccgacgga gacccgtagt gggggaggcg gcggcagcgt
       61 taagtgagaa aggaaaaaag acaacgagga aaaaggaggt gtccgggtag ggcaacgcgg
      121 cgacacccga ggcctggtgg tggcggcgga tcgagatatt caaggctgaa gcagctacgg
      181 aacggcagcg gcggcggtcg gacaaactga ctgaccgagc cgggtggtgg cgggagcagc
      241 gggagcagcc ggaacgatgc cggccgtgag cctcccgccc aaggagaatg cgctcttcaa
      301 gcggatcttg aggtgttatg aacataaaca gtatagaaat ggattgaaat tctgtaaaca
      361 aatactttct aatcccaaat ttgcagagca tggagaaacc ttggctatga aaggattaac
      421 attgaactgt ttggggaaaa aggaagaagc ttatgaattg gttcgtagag gtttgagaaa
      481 tgacttgaag agtcatgtgt gttggcacgt ttatggcctt cttcagaggt cagacaagaa
      541 gtatgatgaa gccattaagt gttacagaaa tgcactaaaa tgggataaag acaatcttca
      601 aatcttaagg gacctttcct tactacagat tcaaatgcga gatcttgagg gttacaggga
      661 aacgaggtat cagttacttc agcttcgacc tgcgcagaga gcatcatgga ttggttatgc
      721 tattgcttac catttattag aagattatga aatggcagca aagattttag aagaatttag
      781 gaaaacacaa cagacatccc ctgacaaggt ggattatgaa tatagtgaac tactcttata
      841 tcagaatcaa gttcttcggg aagcaggtct ctatagagaa gctttggaac atctttgtac
      901 ctatgaaaag cagatttgtg ataaacttgc tgtagaagaa accaaagggg aacttctgtt
      961 gcaactatgt cgtttggaag atgctgcaga tgtttataga ggattgcaag agagaaatcc
     1021 tgaaaactgg gcctattaca aaggcttgga aaaagcactc aagccagcta atatgttaga
     1081 acggctaaaa atttatgagg aagcctggac taaatatccc aggggactgg tgccaagaag
     1141 gctgccgtta aactttttat ctggtgagaa gtttaaagaa tgtttggata agttcctaag
     1201 gatgaatttc agcaagggtt gcccaccagt cttcaatact ttaagatcat tatacaaaga
     1261 caaagaaaag gtggcaatca tagaagagtt agtagtaggt tatgaaacct ctctaaaaag
     1321 ctgccggtta tttaacccca atgatgatgg aaaggaggaa ccaccaacca cattactttg
     1381 ggtccagtac tacttggcac aacattatga caaaattggt cagccatcta ttgctttgga
     1441 gtacataaat actgctattg aaagtacacc tacattaata gaactctttc tcgtgaaagc
     1501 taaaatctat aagcatgctg gaaatattaa agaagctgca aggtggatgg atgaggccca
     1561 ggccttggac acagcagaca gatttatcaa ctccaaatgt gcaaaataca tgctaaaagc
     1621 caacctgatt aaagaagctg aagaaatgtg ctcaaagttt acaagggaag gaacatcagc
     1681 ggtagagaat ttgaatgaaa tgcagtgcat gtggttccaa acagaatgtg cccaggctta
     1741 taaagcaatg aataaatttg gtgaagcact taagaaatgt catgagattg agagacattt
     1801 tatagaaatc actgatgacc agtttgactt tcatacatac tgtatgagga agattaccct
     1861 tagatcatat gtggacttat taaaactaga agatgtactt cgacagcatc cattttactt
     1921 caaggcagca agaattgcta tagagatcta tttgaagctt catgacaacc cccttacaga
     1981 tgagaataaa gaacacgaag ctgatacagc aaacatgtct gacaaagagc taaagaagct
     2041 acgtaataaa caaagaagag ctcaaaagaa agcccagata gaagaagaga aaaaaaatgc
     2101 agaaaaagaa aagcagcaga gaaatcagaa aaagaagaag gatgatgatg atgaggagat
     2161 aggaggtcca aaagaagaac ttattccaga gaaactggcc aaggttgaaa ctccattgga
     2221 agaagctatt aaatttttaa caccgttgaa gaacttggtg aagaacaaga tagagactca
     2281 tctttttgcc tttgagattt actttaggaa agaaaagttt cttttgatgc tacaatcagt
     2341 aaagagggca tttgctattg attctagtca tccctggctt catgagtgta tgattcgtct
     2401 ctttaatact gcagtgtgtg aaagtaaaga tttatctgat acagttagaa cagtattaaa
     2461 acaagaaatg aatcgtcttt ttggagcaac gaatccaaag aattttaatg aaacttttct
     2521 gaaaaggaat tctgattcat tgccacacag attatcagct gccaaaatgg tatattactt
     2581 agatccttct agtcagaagc gagctataga gttggcaaca acacttgatg aatctctcac
     2641 taacagaaac ctccagacat gtatggaggt attggaagcc ttgtatgatg gtagcctagg
     2701 agactgtaaa gaagctgctg aaatttatag agcaaattgt cataagcttt tcccttatgc
     2761 tttggctttc atgcctcctg gatatgaaga ggatatgaag atcacagtta atggagatag
     2821 ttctgcagaa gctgaagaac tggccaatga aatttgaaca tcactaaaca agcaaatgga
     2881 atgactttgg accatatcta gtatataata tttttgtcac gcacctgctg cattgctcta
     2941 acttacacag aatgagagga gtaaatgttc ttgccttcaa atagtgtttt acgtttttta
     3001 tcctgctgaa aaagtatata taaaatatct aacattacag gatagaggtt cagtttctta
     3061 aaaaattaaa gctgctaaaa ttgagtggtt aaaaaagata ccttatccta ttcctcccca
     3121 cccacccatg tttttaaact aatttatata aaatctggag gctgttacag ctaacaaagc
     3181 aggtgtgtgg cagaaatatt actttaaatt tgtcttgtga gattttacta tatctcagac
     3241 agcataaatg ctgttttagc actggattct ttcactgagc acaaagagtt gttggggctt
     3301 tagcatctga ctgattttgt tacggggttg attctgacca taggaagtat gcaatgtgaa
     3361 tcactattta cagagaaacc tacaacagat gcttgatgtt gtagaaactg ggacatatag
     3421 ataccaagca aaattataag aaacctataa ggtgttcaat acgcttgtgt ttccaaaatt
     3481 cactgtacat gatcagtttg gtgttcttgt accacagttt ttaactgaag gaaccagttg
     3541 taacagtctc aattttaact aaaacttgaa gaactaaaac aacaatgcaa acctttcagc
     3601 attgtttggc caaacttgtt aaaactgtaa tgcaagaacc aaatgcactg tgatgtggca
     3661 ccaactaatt agcaagcatg aatttttcac ccaagagtga aaaaaggaaa atctaccatg
     3721 gcttgaagtt aaagagcaga actcctgact accattctat gactgatcaa aagactaata
     3781 gttaaaaacc tcagcaggcc ttgttcacga tatgcagaaa aaaaagtgct gcagtttaga
     3841 tacctctgga atttttccac agtgtcacag gtttgtaata cttgaagccc tacatttcta
     3901 agaatatatt tcttgctcag ttgtttcagg caagcccaag actttgtaat ttttaaaggg
     3961 cccaagattt tttttttttt tttttttttc aaataacaga ccagcttctt tttcttgcag
     4021 ttacagatgt aatttccttt ttgttgtcaa acataaggta ccaaatatga tgcaataaat
     4081 tgttttgaaa aacagttgtg tgaatatttc aactaatctg tgttgggctt ctgtgaaata
     4141 cacaggtgga aacagaggtg caagccagag gcaatgtaat atgctgtaag gctagtgcag
     4201 atgggagctt tttagaaggg gctaagtgct ggtgtcaggg aaattccata atgaagtaga
     4261 atgctgctcc tgcattaaga tttcattgag ggcaaggctg gtggcaggta ctatgaatgt
     4321 aattcataat ttaaaaggaa aactaaaaac tattttgatt tgggaaaatg agccttaatt
     4381 tgttaaacct atacactgag aactagcctc aggcttaata ttctcattgc atttgcaaga
     4441 tctgagcaaa taagattaag taaaacaaat caattgtata tataattgac ctttttgtgg
     4501 aacatgtagt ttatagaaag tatactctaa agggaatttg ccgaagacct tttactgatt
     4561 gaacagttgt gctacaatca acttttcata gtacatgacc tgcattccac atctcagtct
     4621 aacagtttag tagtgatgta aagagaagta caaaccgaac tccagtgctt tgttatgttt
     4681 tattaactgg ccctgtctca ggaacatctt aacagatggc aaaaaaacaa aaactttttt
     4741 tcaactccta tgagtggcaa ctgaagttct tattgttggg aaagaacact agtcctacct
     4801 ctgccactaa tgaggtgttt ggaggaggta ccagccatat aatagggggt gtatgtgtga
     4861 attttgttta aactctactg tatattgaaa tgaaattcat ttatttgtct tgacaatgtt
     4921 caaatgatgt agattgtctt agaatgaata ttcataagta ctcagaactc ttaagatgca
     4981 gatgccaccc gtgaggagct aaattcctaa tgtgtattgt attccaaccc aattttactg
     5041 gaactattga ataaatcttt tattttcttt caggtttact tgatagtgga tacattggtg
     5101 tcagaggacc ttgactgggt tcattttatg tccagacatc acccctgaaa cactgtactg
     5161 tactatcttg ctctgagtag tatcaactgg atcgtctcat atttgcctca ttcatcctat
     5221 taatttcaaa tgatactgtg ggggaaaaac agggttagaa aaacaagtgg aaaaaatgga
     5281 gtgatgttgt aatctaaaca agtgccttat gtttattgct aagaactggt gttaccaacc
     5341 cttttgagaa gaaagggtct cttgacctgt attaacatag gaaagtaaag ttctttttgt
     5401 ttttctttat attcagctac tcttgtcatt tctcgttgaa aaactaaaat ctgactaggt
     5461 tagtttactc agctttaatt agatagttga gtcatatatt ttcaacattt ttctgtatcg
     5521 tatttattat gcacaaaaat aaagtgtgat ctct
//

LOCUS       NM_057179               1381 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens twist homolog 2 (Drosophila) (TWIST2), mRNA.
ACCESSION   NM_057179 XM_499565
VERSION     NM_057179.1  GI:17981707
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Lee,M.S., Lowe,G., Flanagan,S., Kuchler,K. and Glackin,C.A.
  TITLE     Human Dermo-1 has attributes similar to twist in early bone
            development
  JOURNAL   Bone 27 (5), 591-602 (2000)
   PUBMED   11062344
REFERENCE   2  (bases 1 to 1381)
  AUTHORS   Perrin-Schmitt,F., Bolcato-Bellemin,A.L., Bourgeois,P., Stoetzel,C.
            and Danse,J.M.
  TITLE     The locations of the H-twist and H-dermo-1 genes are distinct on
            the human genome
  JOURNAL   Biochim. Biophys. Acta 1360 (1), 1-2 (1997)
   PUBMED   9061034
REFERENCE   3  (bases 1 to 1381)
  AUTHORS   Li,L., Cserjesi,P. and Olson,E.N.
  TITLE     Dermo-1: a novel twist-related bHLH protein expressed in the
            developing dermis
  JOURNAL   Dev. Biol. 172 (1), 280-292 (1995)
   PUBMED   7589808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017907.1.
            On Aug 30, 2004 this sequence version replaced gi:51463852.
            
            Summary: Basic helix-loop-helix (bHLH) transcription factors have
            been implicated in cell lineage determination and differentiation.
            The protein encoded by this gene is a bHLH transcription factor and
            shares similarity with another bHLH transcription factor, Twist. It
            is thought that during osteoblast development this protein may
            inhibit osteoblast maturation and maintain cells in a preosteoblast
            phenotype.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1381
                     /gene="TWIST2"
                     /note="synonym: DERMO1"
                     /db_xref="GeneID:117581"
                     /db_xref="MIM:607556"
     CDS             132..614
                     /gene="TWIST2"
                     /note="twist-related bHLH protein Dermo1; dermis-expressed
                     protein 1;
                     go_component: nucleus [goid 0005634] [evidence IDA] [pmid
                     11062344];
                     go_component: cytoplasm [goid 0005737] [evidence IDA]
                     [pmid 11062344];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: transcriptional repressor activity [goid
                     0016564] [evidence ISS];
                     go_process: cell differentiation [goid 0030154] [evidence
                     IEA];
                     go_process: negative regulation of transcription,
                     DNA-dependent [goid 0045892] [evidence ISS];
                     go_process: negative regulation of osteoblast
                     differentiation [goid 0045668] [evidence IDA] [pmid
                     11062344]"
                     /codon_start=1
                     /product="twist homolog 2"
                     /protein_id="NP_476527.1"
                     /db_xref="GI:17981708"
                     /db_xref="GeneID:117581"
                     /db_xref="MIM:607556"
                     /translation="MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGS
                     PTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLS
                     KIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
                     "
     polyA_signal    1325..1330
                     /gene="TWIST2"
     polyA_site      1349
                     /gene="TWIST2"
ORIGIN      
        1 gcacaagccg gccttgaaat cagagccttt ccagcaactc cgagagcgtg tgctcggcga
       61 ccgcgggctt ggccagcggc gcgcgctcgg cgccccggcg cccccagccc cacgcgcgcc
      121 gggcgggcgc catggaggag ggctccagct cgcccgtgtc ccccgtggac agcctgggca
      181 ccagcgagga ggagctcgag aggcagccca agcgcttcgg ccggaagcgg cgctacagca
      241 agaagtcgag cgaagatggc agcccgaccc cgggcaagcg cggcaagaag ggcagcccca
      301 gcgcgcagtc cttcgaggag ctgcagagcc agcgcatcct ggccaacgtg cgcgagcgcc
      361 agcgcaccca gtcgctcaac gaggccttcg cggcgctgcg caagatcatc cccacgctgc
      421 cctctgacaa gctgagcaag atccagacgc tcaagctggc cgccaggtac atagacttcc
      481 tctaccaggt cctgcagagc gacgagatgg acaataagat gaccagctgc agctacgtgg
      541 cccacgagcg cctcagctac gccttctccg tgtggcgcat ggagggcgcg tggtccatgt
      601 ccgcctccca ctagcgccgc gccacccacc tccggaccgg cgcgccaggg ctgtccgtcg
      661 cgtcggcggc gcaagtggaa ttgggatgca ttcgagtctg taacttctga aacctgaaca
      721 acctcaggag gcccccacct ctgccctcca ccagcgtcga gagaagggac agcagtgaca
      781 tcggacagaa gacccgggct cccgtcctcc cccaggacgg tccccacata ggaagggcac
      841 tcccagccct cttgctggtg acattgtcat ggtcatcttg tttctgtttg gatttttctt
      901 ctgggtctta tgtttggggg gaggtttatt ctttctgaaa atgtctagat tcaggaacac
      961 atttatgagg atttggattt tgaatttgta tttccctcta agtgcctttt ttaatgtcta
     1021 tttttttaat aaaacagaaa tgcattcttg tacaattctg ttgaaactgg accaaggctc
     1081 tcagaagagg acccccgagt tccttcccct cccccgagcc tctgcatgat tgtttcaagt
     1141 cagcctggaa ttcttacttt cacgccgcta ttcttttcct ttctccgtga ttgcttggct
     1201 agccatttta aaaaaaatat tctctgttca gtgtatatgt tgcttgtttg ttttatttat
     1261 tgagatattt ttacaagcta agtgactgca gtgtggctgt gtatcctgct ccccacccag
     1321 gaaaaataaa gacgtccgcg cagccatgga caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 a
//

LOCUS       NM_130468               2156 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens dermatan 4 sulfotransferase 1 (D4ST1), mRNA.
ACCESSION   NM_130468
VERSION     NM_130468.2  GI:31542479
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Mikami,T., Mizumoto,S., Kago,N., Kitagawa,H. and Sugahara,K.
  TITLE     Specificities of three distinct human chondroitin/dermatan
            N-acetylgalactosamine 4-O-sulfotransferases demonstrated using
            partially desulfated dermatan sulfate as an acceptor: implication
            of differential roles in dermatan sulfate biosynthesis
  JOURNAL   J. Biol. Chem. 278 (38), 36115-36127 (2003)
   PUBMED   12847091
  REMARK    GeneRIF: human D4ST-1, C4ST-1, and S4ST-2 have differential roles
            in dermatan sulfate biosynthesis
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Evers,M.R., Xia,G., Kang,H.G., Schachner,M. and Baenziger,J.U.
  TITLE     Molecular cloning and characterization of a dermatan-specific
            N-acetylgalactosamine 4-O-sulfotransferase
  JOURNAL   J. Biol. Chem. 276 (39), 36344-36353 (2001)
   PUBMED   11470797
  REMARK    GeneRIF: D4ST-1 is encoded by a single exon located on human
            chromosome 15q14; type II membrane protein of 376 amino acids with
            a 43-amino acid cytoplasmic domain and a 316-amino acid luminal
            domain containing two potential N-linked glycosylation sites
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC049214.1.
            On Jun 9, 2003 this sequence version replaced gi:18497303.
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2156
                     /gene="D4ST1"
                     /note="synonyms: HD4ST, D4ST-1, HNK1ST"
                     /db_xref="GeneID:113189"
     CDS             201..1331
                     /gene="D4ST1"
                     /note="dermatan-4-sulfotransferase-1;
                     go_component: integral to membrane [goid 0016021]
                     [evidence NAS] [pmid 11470797];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: phosphate binding [goid 0042301] [evidence
                     NAS] [pmid 11470797];
                     go_function: N-acetylgalactosamine 4-O-sulfotransferase
                     activity [goid 0001537] [evidence IDA] [pmid 11470797];
                     go_process: dermatan sulfate proteoglycan metabolism [goid
                     0050655] [evidence IDA] [pmid 11470797]"
                     /codon_start=1
                     /product="dermatan 4 sulfotransferase 1"
                     /protein_id="NP_569735.1"
                     /db_xref="GI:18497304"
                     /db_xref="GeneID:113189"
                     /translation="MFPRPLTPLAAPNGAEPLGRALRRAPLGRARAGLGGPPLLLPSM
                     LMFAVIVASSGLLLMIERGILAEMKPLPLHPPGREGTAWRGKAPKPGGLSLRAGDADL
                     QVRQDVRNRTLRAVCGQPGMPRDPWDLPVGQRRTLLRHILVSDRYRFLYCYVPKVACS
                     NWKRVMKVLAGVLDSVDVRLKMDHRSDLVFLADLRPEEIRYRLQHYFKFLFVREPLER
                     LLSAYRNKFGEIREYQQRYGAEIVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPERMN
                     EHWMPVYHLCQPCAVHYDFVGSYERLEADANQVLEWVRAPPHVRFPARQAWYRPASPE
                     SLHYHLCSAPRALLQDVLPKYILDFSLFAYPLPNVTKEACQQ"
ORIGIN      
        1 cgccgcgccc gccgcccgcc gcccgcttcg gcgccgcagc ccgggagccg gccaccccta
       61 cacgcgccag ggctgtcccc tgccctcccc tccccaacta cccccggtcc cagaccctcc
      121 tcccgccccc agcccgagcc cgccttccag gccgccctcg gatcggccgg gcccgcgcag
      181 gcccccaccc cttgagcacc atgttccccc gcccgctgac cccgctggcg gccccaaatg
      241 gcgccgagcc cctgggccgg gcgctgaggc gggcccctct gggcagggcc cgggcggggc
      301 tgggtgggcc gcccctgctg ctgccgtcca tgctgatgtt tgcggtgatc gtggcctcca
      361 gcgggctgct gctcatgatc gagcggggca tcctggccga gatgaagccc ctgcccctgc
      421 acccgcccgg ccgcgagggc acagcctggc gcgggaaagc ccccaagcct gggggcctgt
      481 ccctcagggc tggggacgcg gacttgcaag tgcggcagga cgtccggaac aggaccctgc
      541 gggcggtgtg cggacagcca ggcatgcccc gggacccctg ggacttgccg gtggggcagc
      601 ggcgcaccct gctgcgccac atcctcgtaa gtgaccgtta ccgcttcctc tactgctacg
      661 tccccaaggt ggcctgctct aactggaagc gggtgatgaa ggtgctggca ggcgtcctgg
      721 acagcgtgga cgtccgcctc aagatggacc accgcagtga cctggtgttc ctggccgacc
      781 tgcggcctga ggagattcgc taccgcctgc agcactactt taagttcctg tttgtgcggg
      841 agcccttgga acgcctcctc tctgcctacc gcaacaagtt tggcgagatc cgagagtacc
      901 agcaacgcta tggggctgag atagtgaggc ggtacagggc tggagcgggg cccagccctg
      961 caggcgacga tgtcacattc cccgagttcc tgagatacct ggtggatgag gaccctgagc
     1021 gcatgaatga gcattggatg cccgtgtacc acctgtgcca gccttgtgcc gtgcactatg
     1081 actttgtggg ctcctatgag aggctggagg ctgatgcaaa tcaggtgctg gagtgggtac
     1141 gggcaccacc tcacgtccga tttccagctc gccaggcctg gtaccggcca gccagccccg
     1201 aaagcctgca ttaccacttg tgcagtgccc cccgggccct gctgcaggat gtgctgccta
     1261 agtatatcct ggacttctcc ctctttgcct acccactgcc taatgtcacc aaggaggcgt
     1321 gtcagcagtg accatgggtg tggggccagc agctggtggg gactggtttc aacgccagct
     1381 ttctgtgctt ctgcctgtca ttcggagaaa ctctggctct ggggcttggg gcttctcagg
     1441 atcctggatg gcagagactg ccctcagaag ttccttgtcc agggtgggca cccacagtga
     1501 ctcagaggac agggctaggc aggagacctg ctgctcctca ttggggggat ctcttggggg
     1561 gcagacacca gtttgccaat gaagcaacac atctgatcta aagactggct ccagaccccg
     1621 ggctgccagg attatgcagt ccacttggtc taccttaatt taacctgtgg ccaaactcag
     1681 agatggtacc agccaggggc aagcatgacc agagccaggg accctgtggc tctgatcccc
     1741 catttatcca ccccatgtgc ctcaggacta gagtgagcaa tcatacctta taaatgactt
     1801 ttgtgccttt ctgctccagt ctcaaaattt cctacacctg ccagttcttt acatttttcc
     1861 aaggaaagga aaacggaagc agggttcttg cctggtagct ccaggaccca gctctgcagg
     1921 cacccaaaga ccctctgtgc ccagcctctt ccttgagttc tcggaacctc ctccctaatt
     1981 ctcccttcct tccccacaag gcctttgagg ttgtgactgt ggctggtata tctggctgcc
     2041 atttttctga tgcatttatt taaaatttgt actttttgat agaacccttg taagggcttt
     2101 gttttcctaa tagctgactt tttaataaag cagttttata taaaaaaaaa aaaaaa
//

LOCUS       NM_133496               5862 bp    mRNA    linear   PRI 26-NOV-2004
DEFINITION  Homo sapiens solute carrier family 30 (zinc transporter), member 7
            (SLC30A7), mRNA.
ACCESSION   NM_133496
VERSION     NM_133496.3  GI:41529827
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5862)
  AUTHORS   Kirschke,C.P. and Huang,L.
  TITLE     ZnT7, a novel mammalian zinc transporter, accumulates zinc in the
            Golgi apparatus
  JOURNAL   J. Biol. Chem. 278 (6), 4096-4102 (2003)
  MEDLINE   22450638
   PUBMED   12446736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064692.1.
            On Feb 1, 2004 this sequence version replaced gi:40255008.
FEATURES             Location/Qualifiers
     source          1..5862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..5862
                     /gene="SLC30A7"
                     /note="synonyms: ZNT7, ZnT-7, ZnTL2"
                     /db_xref="GeneID:148867"
     CDS             142..1272
                     /gene="SLC30A7"
                     /note="zinc transporter ZnT-7;
                     go_component: membrane [goid 0016020] [evidence IEA];
                     go_function: cation transporter activity [goid 0008324]
                     [evidence IEA];
                     go_process: cation transport [goid 0006812] [evidence
                     IEA]"
                     /codon_start=1
                     /product="zinc transporter like 2"
                     /protein_id="NP_598003.2"
                     /db_xref="GI:40255009"
                     /db_xref="GeneID:148867"
                     /translation="MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCL
                     NLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVR
                     AEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFK
                     HGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSH
                     DGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAI
                     LIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVY
                     VGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM"
ORIGIN      
        1 gtctgtctgt gtctcgcagc ggcgcgcggc cccggacaag cgctggggat tcccgtttga
       61 ggcgtcacta ctgtcactgc catcacccca cggagccact tctagagggg agtagacccg
      121 gcccttcgcc gggcagagaa gatgttgccc ctgtccatca aagacgatga atacaaacca
      181 cccaagttca atttgttcgg caagatctcg ggctggttta ggtctatact gtccgacaag
      241 acttcccgga acctgttttt cttcctgtgc ctgaacctct ctttcgcttt tgtggaacta
      301 ctctacggca tctggagcaa ctgcttaggc ttgatttccg actcttttca catgtttttc
      361 gatagcactg ccattttggc tggactggca gcttctgtta tttcaaaatg gagagataat
      421 gatgctttct cctatgggta tgttagagcg gaagttctgg ctggctttgt caatggccta
      481 tttttgatct tcactgcttt ttttattttc tcagaaggag ttgagagagc attagcccct
      541 ccagatgtcc accatgagag actgcttctt gtttccattc ttgggtttgt ggtaaaccta
      601 ataggaatat ttgttttcaa acatggaggt catggacatt ctcatggctc tggccacgga
      661 cacagtcatt ccctctttaa tggtgctcta gatcaggcac atggccatgt cgatcattgc
      721 catagccatg aagtgaaaca tggtgctgca catagccatg atcatgctca tggacatgga
      781 cactttcatt ctcatgatgg cccgtcctta aaagaaacaa caggacccag cagacagatt
      841 ttacaaggtg tatttttaca tatcctagca gatacacttg gaagtattgg tgtaattgct
      901 tctgccatca tgatgcaaaa ttttggtctg atgatagcag atcctatctg ttcaattctt
      961 atagccattc ttatagttgt aagtgttatt cctcttttaa gagaatctgt tggaatatta
     1021 atgcagagaa ctcctcccct attagaaaat agtctgcctc agtgctatca gagggtacag
     1081 cagttgcaag gagtttacag tttacaggaa cagcacttct ggactttatg ttctgacgtt
     1141 tatgttggga ccttgaaatt aatagtagca cctgatgctg atgctaggtg gattttaagc
     1201 caaacacata atatttttac tcaggctgga gtgagacagc tctacgtaca gattgatttt
     1261 gcagccatgt agtgaatgga aagaaattat gcacctttta tggaccaaat ttttctggta
     1321 ctgtacgatc caaaacattg tacccagctt tttaaaagag agaaattatc actacaactc
     1381 ccgagcacta agtagacggg gtagagtcag ccgttcatgc tttgtgggga gttcacagct
     1441 aagggatcag atttaagagg atatctcctg gacttttggt cttttctttt gtgctctttc
     1501 ctccaaatct ttttgacttc tgaggttttt agcttaggat gttaatttgt ccttttgtct
     1561 ttcttttttt gtttttgttt tctgtttgtt tgttttcatg ttgaatgccc acaccaccat
     1621 cctctcatcc cagccagtaa gaatttcagt tgtgggcctc cagtcttctg gaatgtcttc
     1681 actgcagctg ctggaaatca ctgctttcat tcccacaaaa ccagtattac ttttttttaa
     1741 aaaaagaaag aaattggaaa tctgtgctat acgtaatgtc ataattgttg acgttcttca
     1801 gtataatcat gtttgttaaa ttgtttgtac cttgcaaact tatgaaccaa accatattgg
     1861 gttttcaaag tgcctttgta tccaaaaatg tatttgccag catagaaatg taccatcaag
     1921 agtcatgtat gttttatttt tgtttttatt ttttattttt tgagatggag tctcgctctg
     1981 tagccaggct ggagtgcagt ggcataatct cagctcactg caacctctgc ttcccgggtt
     2041 caagctattc tcctgcctca gccttctgag tagctgcgac tatgggcgtg tgccaccatg
     2101 cccagctaat ttttgcattt ttagtagaga tggggtttca ccatgttggc caggatggtc
     2161 ttgatctctt gacctcgtga tccgtccacc tcagcctccc aaagtgctgg gattacaggt
     2221 gtgagccacc acgcccggct atgttttttt tttttttttt ttttttaaca atggatattc
     2281 tgtaaaatat cctgtacaaa acaagactat tgccagtaat gtatacaaat tgtctttttg
     2341 tgtacttcca gcataggttt ggatatatga acatttttct tttattgttt tatcttcaca
     2401 gaaaataaaa ggtgttaatt tgctttttaa aacaaattta attatcacat tttaaattac
     2461 tttgtggact gtgttttcaa aactttgcaa attcatctgt tacacagaaa attttgactt
     2521 aaaacatctg ctgaattcca aatttctgta atagctactg tatctgtgat aaactttcct
     2581 atatctttcc ttgccatttc tatggatttt ataatgaaag aaaaaggcat tggagactga
     2641 aggcagaaat ggttgtgaca gtgctgtttg gctttttcat tcttcaaatg ccaagtcatc
     2701 cactttgttt tcctgtttag gctttgcaca aatacaattg ctttcaggaa tcctaaagca
     2761 gcattttatt gagtttgaat tattaaaggt acagaggaaa tgtggtgatg tagaactttt
     2821 cctaacacag gtatctagga agtaagtgct gagttgattt tctaggttct tacgtatttg
     2881 aaaaataaaa ttgcaattcg agataagtgc ttgagcactc tacttaagta ttctctgtgt
     2941 tttatgaaga gaaaatgatc tgattttccc ttatacttca ttttacaata catattccct
     3001 tttaacttaa aaaaattgta aatgtgggag aaaaaaccct gcaggatgga aacaattatt
     3061 aagaatgtag atcaataagt actttttagt gatgtggcag aaatccctgt tgattctaag
     3121 ttttagagtg tcttttcccc tatttctgac ctacaactat aaactactct ctattaggag
     3181 aactagacca ctttcttcat tcttttctaa actgctgcag attgccgtga actctatcaa
     3241 tagtctcttt tccgcaggca aagtggcatt ttctaaacat gtttgcttac tgccaggtgg
     3301 tttgaaatct atgatttact gcagtagtat gtgcttaaaa caactgttga ggtcttttaa
     3361 gcaggaaagt tcaaaaggaa gtgtcctgat aatggtactg gtttttctac aaatataagt
     3421 agtcattaga agtttgcaac caccaccaag tctgagagaa ctctgggata ttctgtgggt
     3481 tttggcatat tagatagaga aaatgacaga tctagatgaa gggagctttt ggatgtgtgc
     3541 ctttaaaaac tgattatgta taaatactga tatttcacat acggagatat ttgaagaccc
     3601 aagtctgcct ttcacagagc cctccattcc aagtttagtt tttgtcaaaa tatgaatcat
     3661 tttatttgac tgtactatca gtacacaaat gcatgagtat gtttatacag tgttagactg
     3721 atgtgaattt gcatttgtta cattacattg ccagcgcata tcatttagca agttggcatt
     3781 aacatttatg ctttaattaa atgccagtat acctatgtgt gcagcagtaa aaaattagtg
     3841 agaaaaagca actttttgtc actcttagga aatattttgt cttattagtg ttcttggcac
     3901 atgtatatta ctaaagtaga taattccaat gagaaatact accagattat tgttataaaa
     3961 ttaatttaca atgtccctga tattgagcta actcttaaaa aaaccaaaca aaactcgtat
     4021 ctgagtgtaa ctttgccaat attttaaaag ccaaaatatt ctctggacaa caaatttgta
     4081 ttgctcaggg acagtttacc ttgcctggta aaccttccca aacagaaata tagctatact
     4141 atctttggtt ttgttttttg ttttttttgt ttgtttgtat tagatggaat ttcactcttg
     4201 tcgcccaggc tggagtgtag tggcgcagtc tcagctcact gcaacctcca cctcccgggt
     4261 tcaagtgatt ctcctgtctc agctccctga gtaactggaa ttacaggtgc acgccaccac
     4321 gcccggctaa tttttgtgtt tttagcagag acagggtttc accacgttgg ccagggtggt
     4381 cttggactcc tgacctcagg tcatcctcct gcctcggcct cccaaagtgc tgagactaca
     4441 ggtgtgagcc accgtgctca gccactagct ttggtttttt aaacatagat tatattcctc
     4501 aagatgaagg gcttaacata tccacagctt cctcagtttg ctaactcccc atgcatcttt
     4561 gtgaaggaca gtatctagtt tatctgtagg tcagtgttcc ttgtgctgtc atttccctta
     4621 tatctggaat ttgtcagcat tcctgaaaac ctacacgtgt atatcagtaa ccaaaatgct
     4681 atgccttttt tgcacctttg tacagcagcc aaatcatgaa ctcaaaatgt atttgatcac
     4741 agttctataa tgtttttacc tacctattat ggaataatca gtttttacag agattattaa
     4801 tatggtagaa ccctgttatg taattccaaa acttaagaac catatttaca ttgcttaaca
     4861 cagaatttta catctaagca aggactggct ttagaagcag tgtagttcta cctctcattt
     4921 tacagatgag aaaaccgaag cccagaaaaa ctctcatttg ctcaaagtca cagagaaaat
     4981 tagtggcaaa gccaaaaaga ttcagatctt ctgactcgaa gttgagagtt ctttatactc
     5041 tattatgctg cctctccagt gtaatatttg cctttctgta aatgggatta aatatgattt
     5101 gtaaataaag gacatctgac ctcctttttt ggtacattaa ggcactttat aaatggactt
     5161 ttattgtctc atttttcgta tataattatt tccatcatat tctttatgga agatgcaatt
     5221 aattttaact tttttactct tataaaacca gttcctgaca ttttaaaaaa caatatctgt
     5281 aaaatggatc cttttatgag tgaatttttc tgctaattgc ccaaggctaa atccaattta
     5341 aggattgctt agtttcttta ttttgtttat ggtctctgaa ctggtatttt tttataaacc
     5401 aggctaattc acaggtcata ccatttcatt cttgtcgtgt tggcttccag tcactggaaa
     5461 agcttttgca ttttaaagat ttttagagcc atgcaaaact gggcattaaa tgttgcataa
     5521 agcaaatctt ttaagtaagg taaaatgttg aagtcttaac cagaattcct acaactaatt
     5581 actaaaactg ctatttctaa ctcttcatga aagcattacc tttggaaagt taaacttttt
     5641 ttttcctttc atcaccgtct ttgaaacaaa ttattttcca attcataaga actttggtaa
     5701 aaaaaaaaat aaaaggaaat tatatgtttt tctttggaca ttcattggaa ggcttgttga
     5761 agacatgatc ccccagaagc cttagtgacc cagatctcaa ccagagactc aagatagcct
     5821 caaatacagt gaaagattat gtatccaaaa aaaaaaaaaa aa
//

LOCUS       NM_138473               7667 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens Sp1 transcription factor (SP1), mRNA.
ACCESSION   NM_138473 XM_028606
VERSION     NM_138473.2  GI:38372900
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7667)
  AUTHORS   Verma,S.C., Borah,S. and Robertson,E.S.
  TITLE     Latency-associated nuclear antigen of Kaposi's sarcoma-associated
            herpesvirus up-regulates transcription of human telomerase reverse
            transcriptase promoter through interaction with transcription
            factor Sp1
  JOURNAL   J. Virol. 78 (19), 10348-10359 (2004)
   PUBMED   15367601
  REMARK    GeneRIF: results suggest that the interaction of KSHV LANA with Sp1
            up-regulates the telomerase promoter, potentially contributing to
            the immortalization of KSHV-infected cells
REFERENCE   2  (bases 1 to 7667)
  AUTHORS   Tang,S., Bhatia,B., Zhou,J., Maldonado,C.J., Chandra,D., Kim,E.,
            Fischer,S.M., Butler,A.P., Friedman,S.L. and Tang,D.G.
  TITLE     Evidence that Sp1 positively and Sp3 negatively regulate and
            androgen does not directly regulate functional tumor suppressor
            15-lipoxygenase 2 (15-LOX2) gene expression in normal human
            prostate epithelial cells
  JOURNAL   Oncogene 23 (41), 6942-6953 (2004)
   PUBMED   15247906
  REMARK    GeneRIF: Sp1 and Sp3 proteins play a physiologically important role
            in positively and negatively regulating the 15-LOX2 gene
            expression, respectively.
REFERENCE   3  (bases 1 to 7667)
  AUTHORS   Ng,Y., Tan,I., Lim,L. and Leung,T.
  TITLE     Expression of the human myotonic dystrophy kinase-related
            Cdc42-binding kinase gamma is regulated by promoter DNA methylation
            and Sp1 binding
  JOURNAL   J. Biol. Chem. 279 (33), 34156-34164 (2004)
   PUBMED   15194684
  REMARK    GeneRIF: Sp1 has a role in regulating CDC42BPG expression
REFERENCE   4  (bases 1 to 7667)
  AUTHORS   Ding,Z., Gillespie,L.L., Mercer,F.C. and Paterno,G.D.
  TITLE     The SANT domain of human MI-ER1 interacts with Sp1 to interfere
            with GC box recognition and repress transcription from its own
            promoter
  JOURNAL   J. Biol. Chem. 279 (27), 28009-28016 (2004)
   PUBMED   15117948
  REMARK    GeneRIF: the association of hMI-ER1 with Sp1 represents a novel
            mechanism for the negative regulation of Sp1 target promoters
REFERENCE   5  (bases 1 to 7667)
  AUTHORS   Huang,Y.C., Chen,J.Y. and Hung,W.C.
  TITLE     Vitamin D3 receptor/Sp1 complex is required for the induction of
            p27Kip1 expression by vitamin D3
  JOURNAL   Oncogene 23 (28), 4856-4861 (2004)
   PUBMED   15064717
  REMARK    GeneRIF: Suppression of Sp1 expression by small interference RNA
            reduced the stimulation of p27Kip1 promoter activity by vitamin D3
            in prostatic cancer cells,
REFERENCE   6  (bases 1 to 7667)
  AUTHORS   Ou,X.M., Chen,K. and Shih,J.C.
  TITLE     Dual functions of transcription factors, transforming growth
            factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by
            CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene
  JOURNAL   J. Biol. Chem. 279 (20), 21021-21028 (2004)
   PUBMED   15024015
  REMARK    GeneRIF: Transcription factor SP1 has no effect on Monoamine
            oxidase B gene expression.
REFERENCE   7  (bases 1 to 7667)
  AUTHORS   Chen,Q.Y. and Jackson,N.
  TITLE     Human CD1D gene has TATA boxless dual promoters: an SP1-binding
            element determines the function of the proximal promoter
  JOURNAL   J. Immunol. 172 (9), 5512-5521 (2004)
   PUBMED   15100293
  REMARK    GeneRIF: An SP1-binding element determines the function of the TATA
            boxless CD1D-proximal promoter.
REFERENCE   8  (bases 1 to 7667)
  AUTHORS   Sassa,Y., Hata,Y., Aiello,L.P., Taniguchi,Y., Kohno,K. and
            Ishibashi,T.
  TITLE     Bifunctional properties of peroxisome proliferator-activated
            receptor gamma1 in KDR gene regulation mediated via interaction
            with both Sp1 and Sp3
  JOURNAL   Diabetes 53 (5), 1222-1229 (2004)
   PUBMED   15111490
  REMARK    GeneRIF: PPARgamma1 has bifunctional properties in the regulation
            of KDR gene expression mediated via interaction with both Sp1 and
            Sp3
REFERENCE   9  (bases 1 to 7667)
  AUTHORS   Xue,L., Wu,J., Zheng,W., Wang,P., Li,J., Zhang,Z. and Tong,T.
  TITLE     Sp1 is involved in the transcriptional activation of p16(INK4) by
            p21(Waf1) in HeLa cells
  JOURNAL   FEBS Lett. 564 (1-2), 199-204 (2004)
   PUBMED   15094066
  REMARK    GeneRIF: p21(Waf1) can activate the transcription of p16(INK4);
            this effect is GC-box dependent; and the transcription factor Sp1
            plays a key role in this event
REFERENCE   10 (bases 1 to 7667)
  AUTHORS   Moon,S.K., Jung,S.Y. and Kim,C.H.
  TITLE     Transcription factor Sp1 mediates p38MAPK-dependent activation of
            the p21WAF1 gene promoter in vascular smooth muscle cells by
            pyrrolidine dithiocarbamate
  JOURNAL   Biochem. Biophys. Res. Commun. 316 (3), 605-611 (2004)
   PUBMED   15033443
  REMARK    GeneRIF: transcription factor Sp1 is involved in the
            p38MAPK-mediated control of p21WAF1 regulation on vascular smooth
            muscle cells
REFERENCE   11 (bases 1 to 7667)
  AUTHORS   Chakravarty,K., Wu,S.Y., Chiang,C.M., Samols,D. and Hanson,R.W.
  TITLE     SREBP-1c and Sp1 interact to regulate transcription of the gene for
            phosphoenolpyruvate carboxykinase (GTP) in the liver
  JOURNAL   J. Biol. Chem. 279 (15), 15385-15395 (2004)
   PUBMED   14744869
  REMARK    GeneRIF: SREBP-1c and Sp1 interact to regulate transcription of the
            gene for phosphoenolpyruvate carboxykinase (GTP) in the liver
REFERENCE   12 (bases 1 to 7667)
  AUTHORS   Miki,N., Ikuta,M. and Matsui,T.
  TITLE     Hypoxia-induced activation of the retinoic acid receptor-related
            orphan receptor alpha4 gene by an interaction between
            hypoxia-inducible factor-1 and Sp1
  JOURNAL   J. Biol. Chem. 279 (15), 15025-15031 (2004)
   PUBMED   14742449
  REMARK    GeneRIF: the cooperation of HIF-1 with Sp1/Sp3 confers
            transcriptional activation under hypoxia to RORalpha4
REFERENCE   13 (bases 1 to 7667)
  AUTHORS   Maclean,K.N., Kraus,E. and Kraus,J.P.
  TITLE     The dominant role of Sp1 in regulating the cystathionine
            beta-synthase -1a and -1b promoters facilitates potential
            tissue-specific regulation by Kruppel-like factors
  JOURNAL   J. Biol. Chem. 279 (10), 8558-8566 (2004)
   PUBMED   14670973
  REMARK    GeneRIF: Sp1 has a critical and indispensable role in the
            regulation of cystathionine beta-synthase
REFERENCE   14 (bases 1 to 7667)
  AUTHORS   Jinnin,M., Ihn,H., Asano,Y., Yamane,K., Trojanowska,M. and
            Tamaki,K.
  TITLE     Tenascin-C upregulation by transforming growth factor-beta in human
            dermal fibroblasts involves Smad3, Sp1, and Ets1
  JOURNAL   Oncogene 23 (9), 1656-1667 (2004)
   PUBMED   15001984
  REMARK    GeneRIF: a novel, functional binding element in the proximal region
            of the TN-C promoter mediating responsiveness to TGF-beta involving
            Smad3/4, Sp1, Ets1, and CBP/p300
REFERENCE   15 (bases 1 to 7667)
  AUTHORS   Trisciuoglio,D., Iervolino,A., Candiloro,A., Fibbi,G.,
            Fanciulli,M., Zangemeister-Wittke,U., Zupi,G. and Del Bufalo,D.
  TITLE     bcl-2 induction of urokinase plasminogen activator receptor
            expression in human cancer cells through Sp1 activation:
            involvement of ERK1/ERK2 activity
  JOURNAL   J. Biol. Chem. 279 (8), 6737-6745 (2004)
   PUBMED   14660675
  REMARK    GeneRIF: up-regulation of uPAR expression by Bcl-2 in hypoxia is
            modulated by Sp1 DNA binding activity through the ERK signaling
            pathway
REFERENCE   16 (bases 1 to 7667)
  AUTHORS   Fuchs,B., Inwards,C.Y. and Janknecht,R.
  TITLE     Vascular endothelial growth factor expression is up-regulated by
            EWS-ETS oncoproteins and Sp1 and may represent an independent
            predictor of survival in Ewing's sarcoma
  JOURNAL   Clin. Cancer Res. 10 (4), 1344-1353 (2004)
   PUBMED   14977835
  REMARK    GeneRIF: Sp1 has a role in upreglation of VEGF by EWS-ETS
            oncoproteins in Ewing's sarcoma
REFERENCE   17 (bases 1 to 7667)
  AUTHORS   Kramps,C., Strieder,V., Sapetschnig,A., Suske,G. and Lutz,W.
  TITLE     E2F and Sp1/Sp3 Synergize but are not sufficient to activate the
            MYCN gene in neuroblastomas
  JOURNAL   J. Biol. Chem. 279 (7), 5110-5117 (2004)
   PUBMED   14645238
  REMARK    GeneRIF: E2F and Sp1/Sp3 synergize but are not sufficient to
            activate the MYCN gene in neuroblastoma
REFERENCE   18 (bases 1 to 7667)
  AUTHORS   Petz,L.N., Ziegler,Y.S., Schultz,J.R., Kim,H., Kemper,J.K. and
            Nardulli,A.M.
  TITLE     Differential regulation of the human progesterone receptor gene
            through an estrogen response element half site and Sp1 sites
  JOURNAL   J. Steroid Biochem. Mol. Biol. 88 (2), 113-122 (2004)
   PUBMED   15084343
  REMARK    GeneRIF: Sp1 was associated with the +571 estrogen response
            element/Sp1 site in the endogenous progesterone receptor gene in
            the absence and in the presence of estrogen
REFERENCE   19 (bases 1 to 7667)
  AUTHORS   De Siervi,A., Marinissen,M., Diggs,J., Wang,X.F., Pages,G. and
            Senderowicz,A.
  TITLE     Transcriptional activation of p21(waf1/cip1) by alkylphospholipids:
            role of the mitogen-activated protein kinase pathway in the
            transactivation of the human p21(waf1/cip1) promoter by Sp1
  JOURNAL   Cancer Res. 64 (2), 743-750 (2004)
   PUBMED   14744793
  REMARK    GeneRIF: Perifosine increases Sp1 binding and enhanced
            p21(waf1/cip1) transcription.
REFERENCE   20 (bases 1 to 7667)
  AUTHORS   Higuchi,H., Grambihler,A., Canbay,A., Bronk,S.F. and Gores,G.J.
  TITLE     Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression
            via a c-Jun N-terminal kinase-dependent pathway involving Sp1
  JOURNAL   J. Biol. Chem. 279 (1), 51-60 (2004)
   PUBMED   14561739
  REMARK    GeneRIF: Sp1 is a bile acid-responsive transcription factor that
            mediates DR5/TRAIL-R2 gene expression downstream of JNK.
REFERENCE   21 (bases 1 to 7667)
  AUTHORS   Christensen,M.A., Zhou,W., Qing,H., Lehman,A., Philipsen,S. and
            Song,W.
  TITLE     Transcriptional regulation of BACE1, the beta-amyloid precursor
            protein beta-secretase, by Sp1
  JOURNAL   Mol. Cell. Biol. 24 (2), 865-874 (2004)
   PUBMED   14701757
  REMARK    GeneRIF: BACE1 gene expression is tightly regulated at the
            transcriptional level, and transcription factor Sp1 plays an
            important role in regulation of BACE1 to process APP generating
            Abeta in Alzheimer's disease.
REFERENCE   22 (bases 1 to 7667)
  AUTHORS   Kang,H.T., Ju,J.W., Cho,J.W. and Hwang,E.S.
  TITLE     Down-regulation of Sp1 activity through modulation of
            O-glycosylation by treatment with a low glucose mimetic,
            2-deoxyglucose
  JOURNAL   J. Biol. Chem. 278 (51), 51223-51231 (2003)
   PUBMED   14532290
  REMARK    GeneRIF: results suggest that 2-DG, like low glucose or hypoxic
            condition, down-regulates Sp1 activity, but through
            hyper-GlcNAcylation instead of hypo-GlcNAcylation
REFERENCE   23 (bases 1 to 7667)
  AUTHORS   Ge,Y., Jensen,T.L., Matherly,L.H. and Taub,J.W.
  TITLE     Physical and functional interactions between USF and Sp1 proteins
            regulate human deoxycytidine kinase promoter activity
  JOURNAL   J. Biol. Chem. 278 (50), 49901-49910 (2003)
   PUBMED   14514691
  REMARK    GeneRIF: USF and Sp1 proteins interact and regulate human
            deoxycytidine kinase promoter activity
REFERENCE   24 (bases 1 to 7667)
  AUTHORS   Tatewaki,H., Tsuda,H., Kanaji,T., Yokoyama,K. and Hamasaki,N.
  TITLE     Characterization of the human protein S gene promoter: a possible
            role of transcription factors Sp1 and HNF3 in liver
  JOURNAL   Thromb. Haemost. 90 (6), 1029-1039 (2003)
   PUBMED   14652633
  REMARK    GeneRIF: transcription factors HNF3, MAZ, and Sp1 are required for
            high-level expression of the protein S gene in hepatic cells, but
            in non-hepatic cells such as HeLa cells, an unknown factor(s) binds
            to the Sp1 region and disturbs the action of Sp1 and MAZ
REFERENCE   25 (bases 1 to 7667)
  AUTHORS   Wang,Y.N. and Chang,W.C.
  TITLE     Induction of disease-associated keratin 16 gene expression by
            epidermal growth factor is regulated through cooperation of
            transcription factors Sp1 and c-Jun
  JOURNAL   J. Biol. Chem. 278 (46), 45848-45857 (2003)
   PUBMED   12954631
  REMARK    GeneRIF: transcription factors Sp1 and c-Jun have roles in
            regulation of keratin 16 gene expression by epidermal growth factor
REFERENCE   26 (bases 1 to 7667)
  AUTHORS   Rehli,M., Niller,H.H., Ammon,C., Langmann,S., Schwarzfischer,L.,
            Andreesen,R. and Krause,S.W.
  TITLE     Transcriptional regulation of CHI3L1, a marker gene for late stages
            of macrophage differentiation
  JOURNAL   J. Biol. Chem. 278 (45), 44058-44067 (2003)
   PUBMED   12933821
  REMARK    GeneRIF: results indicated a predominant role for a single Sp1
            binding site in regulating human cartilage-gp39 promoter activity
            in macrophages
REFERENCE   27 (bases 1 to 7667)
  AUTHORS   Griffin,J.B., Rodriguez-Melendez,R. and Zempleni,J.
  TITLE     The nuclear abundance of transcription factors Sp1 and Sp3 depends
            on biotin in Jurkat cells
  JOURNAL   J. Nutr. 133 (11), 3409-3415 (2003)
   PUBMED   14608051
  REMARK    GeneRIF: Biotin affects gene expression in Jurkaat cells.
REFERENCE   28 (bases 1 to 7667)
  AUTHORS   Holmes,A., Abraham,D.J., Chen,Y., Denton,C., Shi-wen,X., Black,C.M.
            and Leask,A.
  TITLE     Constitutive connective tissue growth factor expression in
            scleroderma fibroblasts is dependent on Sp1
  JOURNAL   J. Biol. Chem. 278 (43), 41728-41733 (2003)
   PUBMED   12888575
  REMARK    GeneRIF: the constitutive overexpression of CTGF in SSc fibroblasts
            seems to be independent of TGFbeta signaling but dependent at least
            in part on Sp1
REFERENCE   29 (bases 1 to 7667)
  AUTHORS   Zhang,Y. and Dufau,M.L.
  TITLE     Repression of the luteinizing hormone receptor gene promoter by
            cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB
  JOURNAL   Mol. Cell. Biol. 23 (19), 6958-6972 (2003)
   PUBMED   12972613
  REMARK    GeneRIF: SP1 activates transcription of the LHR gene at two SP1
            sites.  Its mutation reduced the inhibition by EAR2 and abolished
            the inhibition by EAR3.
REFERENCE   30 (bases 1 to 7667)
  AUTHORS   Wong,W.K., Chen,K. and Shih,J.C.
  TITLE     Decreased methylation and transcription repressor Sp3 up-regulated
            human monoamine oxidase (MAO) B expression during Caco-2
            differentiation
  JOURNAL   J. Biol. Chem. 278 (38), 36227-36235 (2003)
   PUBMED   12855685
  REMARK    GeneRIF: Sp3 and Sp1 have roles in regulating monoamine oxidase B
            in human tumor cells
REFERENCE   31 (bases 1 to 7667)
  AUTHORS   Magan,N., Szremska,A.P., Isaacs,R.J. and Stowell,K.M.
  TITLE     Modulation of DNA topoisomerase II alpha promoter activity by
            members of the Sp (specificity protein) and NF-Y (nuclear factor Y)
            families of transcription factors
  JOURNAL   Biochem. J. 374 (Pt 3), 723-729 (2003)
   PUBMED   12769819
  REMARK    GeneRIF: Sp1 is found to bind strongly to both distal and proximal
            GC-rich elements as a transcriptional modulator of DNA
            topoisomerase II alpha promoter activity, with activator or
            repressor functions depending on protein/DNA context.
REFERENCE   32 (bases 1 to 7667)
  AUTHORS   Bruning,J.C., Lingohr,P., Gillette,J., Hanstein,B., Avci,H.,
            Krone,W., Muller-Wieland,D. and Kotzka,J.
  TITLE     Estrogen receptor-alpha and Sp1 interact in the induction of the
            low density lipoprotein-receptor
  JOURNAL   J. Steroid Biochem. Mol. Biol. 86 (2), 113-121 (2003)
   PUBMED   14568562
  REMARK    GeneRIF: data provide an alternative mechanism of LDL receptor gene
            expression by non-classical estradiol- and tamoxifen-stimulated
            induction through an ER-alpha/Sp1 complex
REFERENCE   33 (bases 1 to 7667)
  AUTHORS   Ceelie,H., Spaargaren-Van Riel,C.C., De Jong,M., Bertina,R.M. and
            Vos,H.L.
  TITLE     Functional characterization of transcription factor binding sites
            for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the
            human prothrombin gene enhancer
  JOURNAL   J. Thromb. Haemost. 1 (8), 1688-1698 (2003)
   PUBMED   12911579
  REMARK    GeneRIF: HNF4-alpha, HNF3-beta and Sp1/Sp3 are important in
            regulation of prothrombin expression
REFERENCE   34 (bases 1 to 7667)
  AUTHORS   Loregian,A., Bortolozzo,K., Boso,S., Sapino,B., Betti,M.,
            Biasolo,M.A., Caputo,A. and Palu,G.
  TITLE     The Sp1 transcription factor does not directly interact with the
            HIV-1 Tat protein
  JOURNAL   J. Cell. Physiol. 196 (2), 251-257 (2003)
   PUBMED   12811817
REFERENCE   35 (bases 1 to 7667)
  AUTHORS   Liedtke,C., Groger,N., Manns,M.P. and Trautwein,C.
  TITLE     The human caspase-8 promoter sustains basal activity through SP1
            and ETS-like transcription factors and can be up-regulated by a
            p53-dependent mechanism
  JOURNAL   J. Biol. Chem. 278 (30), 27593-27604 (2003)
   PUBMED   12748179
  REMARK    GeneRIF: SP1 and ETS have a role in regulation of caspase 8
REFERENCE   36 (bases 1 to 7667)
  AUTHORS   Xie,R.L., Gupta,S., Miele,A., Shiffman,D., Stein,J.L., Stein,G.S.
            and van Wijnen,A.J.
  TITLE     The tumor suppressor interferon regulatory factor 1 interferes with
            SP1 activation to repress the human CDK2 promoter
  JOURNAL   J. Biol. Chem. 278 (29), 26589-26596 (2003)
   PUBMED   12732645
  REMARK    GeneRIF: IRF1 represses CDK2 gene expression by interfering with
            SP1-dependent transcriptional activation.
REFERENCE   37 (bases 1 to 7667)
  AUTHORS   Le Goff,W., Guerin,M., Petit,L., Chapman,M.J. and Thillet,J.
  TITLE     Regulation of human CETP gene expression: role of SP1 and SP3
            transcription factors at promoter sites -690, -629, and -37
  JOURNAL   J. Lipid Res. 44 (7), 1322-1331 (2003)
   PUBMED   12730302
  REMARK    GeneRIF: Sp1 and Sp3 regulate human CETP promoter activity through
            three Sp1/Sp3 binding sites in a distinct manner
REFERENCE   38 (bases 1 to 7667)
  AUTHORS   Ekstrom,L., Lyrenas,L., Jakobsson,P.J., Morgenstern,R. and
            Kelner,M.J.
  TITLE     Basal expression of the human MAPEG members microsomal glutathione
            transferase 1 and prostaglandin E synthase genes is mediated by Sp1
            and Sp3
  JOURNAL   Biochim. Biophys. Acta 1627 (2-3), 79-84 (2003)
   PUBMED   12818425
  REMARK    GeneRIF: The results indicate that Sp1 is the protein mediating the
            basal transcription of MGST1. It appears that both the Sp1 and Sp3
            proteins are important for the basal expression of PGES
REFERENCE   39 (bases 1 to 7667)
  AUTHORS   Kang-Park,S., Lee,Y.I. and Lee,Y.I.
  TITLE     PTEN modulates insulin-like growth factor II (IGF-II)-mediated
            signaling; the protein phosphatase activity of PTEN downregulates
            IGF-II expression in hepatoma cells
  JOURNAL   FEBS Lett. 545 (2-3), 203-208 (2003)
   PUBMED   12804776
  REMARK    GeneRIF: PTEN expression induced decreased SP1 DNA binding by
            dephosphorylating SP1.
REFERENCE   40 (bases 1 to 7667)
  AUTHORS   Ishii,H., Tezuka,T., Ishikawa,H., Takada,K., Oida,K. and Horie,S.
  TITLE     Oxidized phospholipids in oxidized low-density lipoprotein
            down-regulate thrombomodulin transcription in vascular endothelial
            cells through a decrease in the binding of RARbeta-RXRalpha
            heterodimers and Sp1 and Sp3 to their binding sequences in the TM
            promoter
  JOURNAL   Blood 101 (12), 4765-4774 (2003)
   PUBMED   12576329
  REMARK    GeneRIF: results suggest that oxidized phospholipids inhibit
            transcription of the thrombomodulin gene in vascular endothelium by
            inhibiting the binding of retinoic acid receptor beta-retinoid x
            receptor alpha heterodimer and Sp1 and Sp3 to thrombomodulin
            promoter
REFERENCE   41 (bases 1 to 7667)
  AUTHORS   Bontemps,Y., Vuillermoz,B., Antonicelli,F., Perreau,C., Danan,J.L.,
            Maquart,F.X. and Wegrowski,Y.
  TITLE     Specific protein-1 is a universal regulator of UDP-glucose
            dehydrogenase expression: its positive involvement in transforming
            growth factor-beta signaling and inhibition in hypoxia
  JOURNAL   J. Biol. Chem. 278 (24), 21566-21575 (2003)
   PUBMED   12682078
  REMARK    GeneRIF: Specific protein-1 is a universal regulator of UDP-glucose
            dehydrogenase expression: its positive involvement in transforming
            growth factor-beta signaling and inhibition in hypoxia
REFERENCE   42 (bases 1 to 7667)
  AUTHORS   Rance,J.B., Follows,G.A., Cockerill,P.N., Bonifer,C., Lane,D.A. and
            Simmonds,R.E.
  TITLE     Regulation of the human endothelial cell protein C receptor gene
            promoter by multiple Sp1 binding sites
  JOURNAL   Blood 101 (11), 4393-4401 (2003)
   PUBMED   12560236
  REMARK    GeneRIF: Functional analysis of a hypersensitive site in the 5'
            flanking region of the hEPCR gene in endothelial cells identified
            multiple regions, containing high and low homology consensus Sp1
            binding sequences, that were protected from methylation.
REFERENCE   43 (bases 1 to 7667)
  AUTHORS   Loregian,A., Bortolozzo,K., Boso,S., Caputo,A. and Palu,G.
  TITLE     Interaction of Sp1 transcription factor with HIV-1 Tat protein:
            looking for cellular partners
  JOURNAL   FEBS Lett. 543 (1-3), 61-65 (2003)
   PUBMED   12753906
REFERENCE   44 (bases 1 to 7667)
  AUTHORS   Arinze,I.J. and Kawai,Y.
  TITLE     Sp family of transcription factors is involved in valproic
            acid-induced expression of Galphai2
  JOURNAL   J. Biol. Chem. 278 (20), 17785-17791 (2003)
   PUBMED   12624107
  REMARK    GeneRIF: Sp1 has a role in valproic acid-induced expression of
            Galphai2
REFERENCE   45 (bases 1 to 7667)
  AUTHORS   Nicolas,M., Noe,V. and Ciudad,C.J.
  TITLE     Transcriptional regulation of the human Sp1 gene promoter by the
            specificity protein (Sp) family members nuclear factor Y (NF-Y) and
            E2F
  JOURNAL   Biochem. J. 371 (Pt 2), 265-275 (2003)
   PUBMED   12513689
REFERENCE   46 (bases 1 to 7667)
  AUTHORS   Chou,S.F., Chen,H.L. and Lu,S.C.
  TITLE     Sp1 and Sp3 are involved in up-regulation of human
            deoxyribonuclease II transcription during differentiation of HL-60
            cells
  JOURNAL   Eur. J. Biochem. 270 (8), 1855-1862 (2003)
   PUBMED   12694199
  REMARK    GeneRIF: This protein and Sp3 are involved in up-regulation of
            human deoxyribonuclease II transcription during differentiation of
            HL-60 cells.
REFERENCE   47 (bases 1 to 7667)
  AUTHORS   Foti,D., Iuliano,R., Chiefari,E. and Brunetti,A.
  TITLE     A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y
            controls human insulin receptor gene transcription
  JOURNAL   Mol. Cell. Biol. 23 (8), 2720-2732 (2003)
   PUBMED   12665574
  REMARK    GeneRIF: HMGI-Y physically interacts with Sp1 and C/EBP beta and
            facilitates the binding of both factors to the insulin receptor
            promoter
REFERENCE   48 (bases 1 to 7667)
  AUTHORS   Poon,B. and Chen,I.S.
  TITLE     Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression
            from unintegrated HIV-1 DNA
  JOURNAL   J. Virol. 77 (7), 3962-3972 (2003)
   PUBMED   12634356
REFERENCE   49 (bases 1 to 7667)
  AUTHORS   Schafer,G., Cramer,T., Suske,G., Kemmner,W., Wiedenmann,B. and
            Hocker,M.
  TITLE     Oxidative stress regulates vascular endothelial growth factor-A
            gene transcription through Sp1- and Sp3-dependent activation of two
            proximal GC-rich promoter elements
  JOURNAL   J. Biol. Chem. 278 (10), 8190-8198 (2003)
   PUBMED   12509426
  REMARK    GeneRIF: role in regulating vascular endothelial growth factor-A
            gene transcription by activating two proximal GC-rich promoter
            elements
REFERENCE   50 (bases 1 to 7667)
  AUTHORS   Kaluz,S., Kaluzova,M. and Stanbridge,E.J.
  TITLE     Expression of the hypoxia marker carbonic anhydrase IX is
            critically dependent on SP1 activity. Identification of a novel
            type of hypoxia-responsive enhancer
  JOURNAL   Cancer Res. 63 (5), 917-922 (2003)
   PUBMED   12615703
  REMARK    GeneRIF: Expression of the hypoxia marker carbonic anhydrase IX is
            critically dependent on SP1 activity.
REFERENCE   51 (bases 1 to 7667)
  AUTHORS   Yedavalli,V.S., Benkirane,M. and Jeang,K.T.
  TITLE     Tat and trans-activation-responsive (TAR) RNA-independent induction
            of HIV-1 long terminal repeat by human and murine cyclin T1
            requires Sp1
  JOURNAL   J. Biol. Chem. 278 (8), 6404-6410 (2003)
   PUBMED   12458222
  REMARK    GeneRIF: Tat and trans-activation-responsive (TAR) RNA-independent
            induction of HIV-1 long terminal repeat by human and murine cyclin
            T1 requires this protein.
REFERENCE   52 (bases 1 to 7667)
  AUTHORS   Brenneisen,P., Blaudschun,R., Gille,J., Schneider,L., Hinrichs,R.,
            Wlaschek,M., Eming,S. and Scharffetter-Kochanek,K.
  TITLE     Essential role of an activator protein-2 (AP-2)/specificity protein
            1 (Sp1) cluster in the UVB-mediated induction of the human vascular
            endothelial growth factor in HaCaT keratinocytes
  JOURNAL   Biochem. J. 369 (Pt 2), 341-349 (2003)
   PUBMED   12358602
  REMARK    GeneRIF: findings underline an essential role of AP-2/Sp1
            recognition sites in UVB-mediated VEGF expression by the
            keratinocyte-derived cell line HaCaT
REFERENCE   53 (bases 1 to 7667)
  AUTHORS   French,S.W., Malone,C.S., Shen,R.R., Renard,M., Henson,S.E.,
            Miner,M.D., Wall,R. and Teitell,M.A.
  TITLE     Sp1 transactivation of the TCL1 oncogene
  JOURNAL   J. Biol. Chem. 278 (2), 948-955 (2003)
   PUBMED   12421830
  REMARK    GeneRIF: TCL1 oncogene transactivation by Sp1.
REFERENCE   54 (bases 1 to 7667)
  AUTHORS   Bush,T.S., St  Coeur,M., Resendes,K.K. and Rosmarin,A.G.
  TITLE     GA-binding protein (GABP) and Sp1 are required, along with retinoid
            receptors, to mediate retinoic acid responsiveness of CD18 (beta 2
            leukocyte integrin): a novel mechanism of transcriptional
            regulation in myeloid cells
  JOURNAL   Blood 101 (1), 311-317 (2003)
   PUBMED   12485937
  REMARK    GeneRIF: GA-binding protein (GABP) and Sp1 and retinoid receptors
            are required to mediate retinoic acid responsiveness of CD18
            transcriptional activation in myeloid cells.
REFERENCE   55 (bases 1 to 7667)
  AUTHORS   Hogan,T.H., Nonnemacher,M.R., Krebs,F.C., Henderson,A. and
            Wigdahl,B.
  TITLE     HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and
            adjacent regions is sequence-specific
  JOURNAL   Biomed. Pharmacother. 57 (1), 41-48 (2003)
   PUBMED   12642036
REFERENCE   56 (bases 1 to 7667)
  AUTHORS   Holmes,M.L., Bartle,N., Eisbacher,M. and Chong,B.H.
  TITLE     Cloning and analysis of the thrombopoietin-induced
            megakaryocyte-specific glycoprotein VI promoter and its regulation
            by GATA-1, Fli-1, and Sp1
  JOURNAL   J. Biol. Chem. 277 (50), 48333-48341 (2002)
   PUBMED   12359731
  REMARK    GeneRIF: role in regulating megakaryocyte-specific glycoprotein VI
            promoter
REFERENCE   57 (bases 1 to 7667)
  AUTHORS   Ge,Y., Jensen,T.L., Matherly,L.H. and Taub,J.W.
  TITLE     Synergistic regulation of human cystathionine-beta-synthase-1b
            promoter by transcription factors NF-YA isoforms and Sp1
  JOURNAL   Biochim. Biophys. Acta 1579 (2-3), 73-80 (2002)
   PUBMED   12427542
  REMARK    GeneRIF: confirms the synergistic transactivating role of NF-YA
            isoforms and Sp1 for the cystathionine beta synthase 1b promoter
REFERENCE   58 (bases 1 to 7667)
  AUTHORS   Chiefari,E., Brunetti,A., Arturi,F., Bidart,J.M., Russo,D.,
            Schlumberger,M. and Filetti,S.
  TITLE     Increased expression of AP2 and Sp1 transcription factors in human
            thyroid tumors: a role in NIS expression regulation?
  JOURNAL   (er) BMC Cancer 2 (1), 35 (2002)
   PUBMED   12475396
  REMARK    GeneRIF: Alterations in the binding activity of Sp1 transcription
            factor to the sodium/iodide symporter (NIS) promoter results at
            least in part in reduced expression and transport of NIS in thyroid
            tumors.
REFERENCE   59 (bases 1 to 7667)
  AUTHORS   D'Addario,M., Arora,P.D., Ellen,R.P. and McCulloch,C.A.
  TITLE     Interaction of p38 and Sp1 in a mechanical force-induced, beta 1
            integrin-mediated transcriptional circuit that regulates the
            actin-binding protein filamin-A
  JOURNAL   J. Biol. Chem. 277 (49), 47541-47550 (2002)
   PUBMED   12324467
  REMARK    GeneRIF: there is a mechanically coupled transcriptional circuit
            that promotes binding of p38 to Sp1 in the nucleus
REFERENCE   60 (bases 1 to 7667)
  AUTHORS   Zhu,G.H., Lenzi,M. and Schwartz,E.L.
  TITLE     The Sp1 transcription factor contributes to the tumor necrosis
            factor-induced expression of the angiogenic factor thymidine
            phosphorylase in human colon carcinoma cells
  JOURNAL   Oncogene 21 (55), 8477-8485 (2002)
   PUBMED   12466967
  REMARK    GeneRIF: role for Sp1 in the regulation of expression of the
            angiogenic factor TP in colon cancer WiDr cells
REFERENCE   61 (bases 1 to 7667)
  AUTHORS   Sanchez-Elsner,T., Botella,L.M., Velasco,B., Langa,C. and
            Bernabeu,C.
  TITLE     Endoglin expression is regulated by transcriptional cooperation
            between the hypoxia and transforming growth factor-beta pathways
  JOURNAL   J. Biol. Chem. 277 (46), 43799-43808 (2002)
   PUBMED   12228247
  REMARK    GeneRIF: Sp1 regulates basal endoglin transcription in human and
            mammalian cells
REFERENCE   62 (bases 1 to 7667)
  AUTHORS   Whetstine,J.R., Witt,T.L. and Matherly,L.H.
  TITLE     The human reduced folate carrier gene is regulated by the AP2 and
            sp1 transcription factor families and a functional 61-base pair
            polymorphism
  JOURNAL   J. Biol. Chem. 277 (46), 43873-43880 (2002)
   PUBMED   12228234
  REMARK    GeneRIF: Sp1 regulates human reduced folate carrier gene expression
REFERENCE   63 (bases 1 to 7667)
  AUTHORS   Chadjichristos,C., Ghayor,C., Herrouin,J.F., Ala-Kokko,L.,
            Suske,G., Pujol,J.P. and Galera,P.
  TITLE     Down-regulation of human type II collagen gene expression by
            transforming growth factor-beta 1 (TGF-beta 1) in articular
            chondrocytes involves SP3/SP1 ratio
  JOURNAL   J. Biol. Chem. 277 (46), 43903-43917 (2002)
   PUBMED   12186868
  REMARK    GeneRIF: TGF-beta1 inhibition of COL2A1 gene transcription in
            articular chondrocytes is mediated by an increase of the Sp3/Sp1
            ratio and by the repression of Sp1 transactivating effects on that
            gene
REFERENCE   64 (bases 1 to 7667)
  AUTHORS   Lin,H.M., Pestell,R.G., Raz,A. and Kim,H.R.
  TITLE     Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a
            cAMP-responsive element in human breast epithelial cells
  JOURNAL   Oncogene 21 (52), 8001-8010 (2002)
   PUBMED   12439750
  REMARK    GeneRIF: role in enhancing cyclin D1 promoter activity in
            conjunction with galectin-3
REFERENCE   65 (bases 1 to 7667)
  AUTHORS   Nogues,G., Kadener,S., Cramer,P., Bentley,D. and Kornblihtt,A.R.
  TITLE     Transcriptional activators differ in their abilities to control
            alternative splicing
  JOURNAL   J. Biol. Chem. 277 (45), 43110-43114 (2002)
   PUBMED   12221105
REFERENCE   66 (bases 1 to 7667)
  AUTHORS   Ibanez-Tallon,I., Ferrai,C., Longobardi,E., Facetti,I., Blasi,F.
            and Crippa,M.P.
  TITLE     Binding of Sp1 to the proximal promoter links constitutive
            expression of the human uPA gene and invasive potential of PC3
            cells
  JOURNAL   Blood 100 (9), 3325-3332 (2002)
   PUBMED   12384434
  REMARK    GeneRIF: Binding of Sp1 to the proximal promoter links constitutive
            expression of the human uPA Phosphorylation of Sp1 determines the
            presence in vivo and the functionality of the GC-/GA-rich element
            of the uPA regulatory region in PC3 cells
REFERENCE   67 (bases 1 to 7667)
  AUTHORS   Takahashi,S., Matsuura,N., Kurokawa,T., Takahashi,Y. and Miura,T.
  TITLE     Co-operation of the transcription factor hepatocyte nuclear
            factor-4 with Sp1 or Sp3 leads to transcriptional activation of the
            human haem oxygenase-1 gene promoter in a hepatoma cell line
  JOURNAL   Biochem. J. 367 (Pt 3), 641-652 (2002)
   PUBMED   12133007
  REMARK    GeneRIF: cooperation with hepatocyte nuclear factor-4 leads to
            transcriptional activation of the human haem oxygenase-1 gene
            promoter in a hepatoma cell line
REFERENCE   68 (bases 1 to 7667)
  AUTHORS   Koutsodontis,G., Moustakas,A. and Kardassis,D.
  TITLE     The role of Sp1 family members, the proximal GC-rich motifs, and
            the upstream enhancer region in the regulation of the human cell
            cycle inhibitor p21WAF-1/Cip1 gene promoter
  JOURNAL   Biochemistry 41 (42), 12771-12784 (2002)
   PUBMED   12379120
  REMARK    GeneRIF: Sp1 binds to specific elements of the proximal promoter
            and interacts with factors bound to distal enhancer elements to
            govern the hepatic activity of the p21 promoter under basal or
            inducible conditions.
REFERENCE   69 (bases 1 to 7667)
  AUTHORS   Uchida,C., Oda,T., Sugiyama,T., Otani,S., Kitagawa,M. and
            Ichiyama,A.
  TITLE     The role of Sp1 and AP-2 in basal and protein kinase A--induced
            expression of mitochondrial serine:pyruvate aminotransferase in
            hepatocytes
  JOURNAL   J. Biol. Chem. 277 (42), 39082-39092 (2002)
   PUBMED   12169688
  REMARK    GeneRIF: Sp1 plays a role in regulation of promoter activity and in
            PKA-mediated expression of mitochondrial serine:pyruvate
            aminotransferase
REFERENCE   70 (bases 1 to 7667)
  AUTHORS   Won,J., Yim,J. and Kim,T.K.
  TITLE     Sp1 and Sp3 recruit histone deacetylase to repress transcription of
            human telomerase reverse transcriptase (hTERT) promoter in normal
            human somatic cells
  JOURNAL   J. Biol. Chem. 277 (41), 38230-38238 (2002)
   PUBMED   12151407
  REMARK    GeneRIF: Results suggest that Sp1 and Sp3 associate with the hTERT
            promoter, recruiting HDAC for the localized deacetylation of
            nucleosomal histones and transcriptional silencing of the hTERT
            gene in normal human somatic cells
REFERENCE   71 (bases 1 to 7667)
  AUTHORS   Barth,N., Langmann,T., Sch, Schmitz,G. and Sch.
  TITLE     Identification of regulatory elements in the human adipose most
            abundant gene transcript-1 (apM-1) promoter: role of SP1/SP3 and
            TNF-alpha as regulatory pathways
  JOURNAL   Diabetologia 45 (10), 1425-1433 (2002)
   PUBMED   12378384
  REMARK    GeneRIF: This protein plays a role in the identification of
            regulatory elements in the human adipose most abundant gene
            transcript-1(apM-1)promoter.
REFERENCE   72 (bases 1 to 7667)
  AUTHORS   Kavurma,M.M., Bobryshev,Y. and Khachigian,L.M.
  TITLE     Ets-1 positively regulates Fas ligand transcription via cooperative
            interactions with Sp1
  JOURNAL   J. Biol. Chem. 277 (39), 36244-36252 (2002)
   PUBMED   11970950
  REMARK    GeneRIF: Ets-1 and Sp1 have a role in regulating FasL expression in
            human vascular smooth muscle cells
REFERENCE   73 (bases 1 to 7667)
  AUTHORS   Goldberg,H.J., Whiteside,C.I. and Fantus,I.G.
  TITLE     The hexosamine pathway regulates the plasminogen activator
            inhibitor-1 gene promoter and Sp1 transcriptional activation
            through protein kinase C-beta I and -delta
  JOURNAL   J. Biol. Chem. 277 (37), 33833-33841 (2002)
   PUBMED   12105191
  REMARK    GeneRIF: The hexosamine pathway regulates the plasminogen activator
            inhibitor-1 gene promoter and Sp1 transcriptional activation
            through protein kinase C-betaI and -delta.
REFERENCE   74 (bases 1 to 7667)
  AUTHORS   Choi,H.S., Lee,J.H., Park,J.G. and Lee,Y.I.
  TITLE     Trichostatin A, a histone deacetylase inhibitor, activates the
            IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells:
            alteration of the Sp1/Sp3/HDAC1 multiprotein complex
  JOURNAL   Biochem. Biophys. Res. Commun. 296 (4), 1005-1012 (2002)
   PUBMED   12200149
  REMARK    GeneRIF: IGFBP-3 promoter is activated by Trichostatin
            A-upregulated Sp1
REFERENCE   75 (bases 1 to 7667)
  AUTHORS   Blais,A., Monte,D., Pouliot,F. and Labrie,C.
  TITLE     Regulation of the human cyclin-dependent kinase inhibitor p18INK4c
            by the transcription factors E2F1 and Sp1
  JOURNAL   J. Biol. Chem. 277 (35), 31679-31693 (2002)
   PUBMED   12077144
  REMARK    GeneRIF: conclude that E2F proteins and Sp1 play an important role
            in the control of p18 expression
REFERENCE   76 (bases 1 to 7667)
  AUTHORS   Abdelrahim,M., Samudio,I., Smith,R. III, Burghardt,R. and Safe,S.
  TITLE     Small inhibitory RNA duplexes for Sp1 mRNA block basal and
            estrogen-induced gene expression and cell cycle progression in
            MCF-7 breast cancer cells
  JOURNAL   J. Biol. Chem. 277 (32), 28815-28822 (2002)
   PUBMED   12052832
  REMARK    GeneRIF: demonstrates role of the Sp1 protein in basal and
            estrogen-induced growth and gene expression in breast cancer
REFERENCE   77 (bases 1 to 7667)
  AUTHORS   Hong,C., Kim,H.A., Firestone,G.L. and Bjeldanes,L.F.
  TITLE     3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in
            human breast cancer cells that is accompanied by Sp1-mediated
            activation of p21(WAF1/CIP1) expression
  JOURNAL   Carcinogenesis 23 (8), 1297-1305 (2002)
   PUBMED   12151347
  REMARK    GeneRIF: role in activating p21(WAF/CIP1) expression accompanying
            3,3'-diindolylmethane induced G(1) cell cycle arrest in human
            breast cancer cells
REFERENCE   78 (bases 1 to 7667)
  AUTHORS   Takada,N., Sanda,T., Okamoto,H., Yang,J.P., Asamitsu,K., Sarol,L.,
            Kimura,G., Uranishi,H., Tetsuka,T. and Okamoto,T.
  TITLE     RelA-associated inhibitor blocks transcription of human
            immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1
            actions
  JOURNAL   J. Virol. 76 (16), 8019-8030 (2002)
   PUBMED   12134007
  REMARK    GeneRIF: RAI acts as an efficient inhibitor of HIV-1 gene
            expression in which both NF-kappaB and Sp1 play major roles.
REFERENCE   79 (bases 1 to 7667)
  AUTHORS   Kim,D.B. and DeLuca,N.A.
  TITLE     Phosphorylation of transcription factor Sp1 during herpes simplex
            virus type 1 infection
  JOURNAL   J. Virol. 76 (13), 6473-6479 (2002)
   PUBMED   12050359
  REMARK    GeneRIF: phosphorylated during late Herpes simplex virus type 1
            infection and may contribute to decrease of IE and E gene
            expression
REFERENCE   80 (bases 1 to 7667)
  AUTHORS   Tang,M., Mazella,J., Gao,J. and Tseng,L.
  TITLE     Progesterone receptor activates its promoter activity in human
            endometrial stromal cells
  JOURNAL   Mol. Cell. Endocrinol. 192 (1-2), 45-53 (2002)
   PUBMED   12088866
  REMARK    GeneRIF: Mutation of the progesterone receptor promoter Sp1 site
            eliminated the effect of hPR activation. Activity was increased by
            Sp1 overexpression. Dephosphorylated Sp1, abundant in decidual
            cells, enhances binding to DNA & hPR increasing promoter activity.
REFERENCE   81 (bases 1 to 7667)
  AUTHORS   Dunah,A.W., Jeong,H., Griffin,A., Kim,Y.M., Standaert,D.G.,
            Hersch,S.M., Mouradian,M.M., Young,A.B., Tanese,N. and Krainc,D.
  TITLE     Sp1 and TAFII130 transcriptional activity disrupted in early
            Huntington's disease
  JOURNAL   Science 296 (5576), 2238-2243 (2002)
   PUBMED   11988536
  REMARK    GeneRIF: huntingtin interacts with Sp1 and TAFII130;
            transcriptional activity of SP1 and TAFII130 disrupted in early
            Huntingtin's Disease
REFERENCE   82 (bases 1 to 7667)
  AUTHORS   Pang,J.X., Chen,X.Y. and Wu,S.G.
  TITLE     Regulation of telomerase activity in Jurkat T cells by
            transcription factors Sp1 and Sp3
  JOURNAL   Di Yi Jun Yi Da Xue Xue Bao 22 (6), 481-485 (2002)
   PUBMED   12297462
  REMARK    GeneRIF: role of transcription factors Sp1 and Sp3 in the
            regulation of telomerase activity and human telomerase reverse
            transcriptase (hTERT) in Jurkat T cells
REFERENCE   83 (bases 1 to 7667)
  AUTHORS   Gordon-Shaag,A., Ben-Nun-Shaul,O., Roitman,V., Yosef,Y. and
            Oppenheim,A.
  TITLE     Cellular transcription factor Sp1 recruits simian virus 40 capsid
            proteins to the viral packaging signal, ses
  JOURNAL   J. Virol. 76 (12), 5915-5924 (2002)
   PUBMED   12021324
  REMARK    GeneRIF: recruits SV40 capsid proteins to the viral packaging
            signal, ses
REFERENCE   84 (bases 1 to 7667)
  AUTHORS   Roder,K., Kim,K.H. and Sul,H.S.
  TITLE     Induction of murine H-rev107 gene expression by growth arrest and
            histone acetylation: involvement of an Sp1/Sp3-binding GC-box
  JOURNAL   Biochem. Biophys. Res. Commun. 294 (1), 63-70 (2002)
   PUBMED   12054741
REFERENCE   85 (bases 1 to 7667)
  AUTHORS   Gyrd-Hansen,M., Krag,T.O., Rosmarin,A.G. and Khurana,T.S.
  TITLE     Sp1 and the ets-related transcription factor complex GABP
            alpha/beta functionally cooperate to activate the utrophin promoter
  JOURNAL   J. Neurol. Sci. 197 (1-2), 27-35 (2002)
   PUBMED   11997063
  REMARK    GeneRIF: Sp1 and the ets-related transcription factor complex GABP
            alpha/beta functionally cooperate to activate the utrophin
            promoter.
REFERENCE   86 (bases 1 to 7667)
  AUTHORS   Leung-Pineda,V. and Kilberg,M.S.
  TITLE     Role of Sp1 and Sp3 in the nutrient-regulated expression of the
            human asparagine synthetase gene
  JOURNAL   J. Biol. Chem. 277 (19), 16585-16591 (2002)
   PUBMED   11867623
  REMARK    GeneRIF: Role of Sp1 and Sp3 in the nutrient-regulated expression
            of the human asparagine synthetase gene
REFERENCE   87 (bases 1 to 7667)
  AUTHORS   Nawrocki,A.R., Goldring,C.E., Kostadinova,R.M., Frey,F.J. and
            Frey,B.M.
  TITLE     In vivo footprinting of the human 11beta-hydroxysteroid
            dehydrogenase type 2 promoter: evidence for cell-specific
            regulation by Sp1 and Sp3
  JOURNAL   J. Biol. Chem. 277 (17), 14647-14656 (2002)
   PUBMED   11850421
  REMARK    GeneRIF: role in regulating 11beta-hydroxysteroid dehydrogenase
            type 2 promoter
REFERENCE   88 (bases 1 to 7667)
  AUTHORS   Im,H.J., Pittelkow,M.R. and Kumar,R.
  TITLE     Divergent regulation of the growth-promoting gene IEX-1 by the p53
            tumor suppressor and Sp1
  JOURNAL   J. Biol. Chem. 277 (17), 14612-14621 (2002)
   PUBMED   11844788
  REMARK    GeneRIF: role in regulating growth-promoting gene IEX-1
REFERENCE   89 (bases 1 to 7667)
  AUTHORS   Langmann,T., Porsch-Ozcurumez,M., Heimerl,S., Probst,M., Moehle,C.,
            Taher,M., Borsukova,H., Kielar,D., Kaminski,W.E.,
            Dittrich-Wengenroth,E. and Schmitz,G.
  TITLE     Identification of sterol-independent regulatory elements in the
            human ATP-binding cassette transporter A1 promoter: role of Sp1/3,
            E-box binding factors, and an oncostatin M-responsive element
  JOURNAL   J. Biol. Chem. 277 (17), 14443-14450 (2002)
   PUBMED   11839742
  REMARK    GeneRIF: role in identifying sterol-indendent regulatory elements
            in human ATP-binding cassette transporter A1 promoter
REFERENCE   90 (bases 1 to 7667)
  AUTHORS   Hughes,T.R., Tengku-Muhammad,T.S., Irvine,S.A. and Ramji,D.P.
  TITLE     A novel role of Sp1 and Sp3 in the interferon-gamma -mediated
            suppression of macrophage lipoprotein lipase gene transcription
  JOURNAL   J. Biol. Chem. 277 (13), 11097-11106 (2002)
   PUBMED   11796707
  REMARK    GeneRIF: role in interferon-gamma mediated suppression of
            macrophage lipoprotein lipase gene transcription
REFERENCE   91 (bases 1 to 7667)
  AUTHORS   Heusohn,F., Wirries,G., Schmidt,R.E. and Gessner,J.E.
  TITLE     The Pmed1 gene promoter of human Fc gamma RIIIA can function as a
            NK/T cell-specific restriction element, which involves binding of
            Sp1 transcription factor
  JOURNAL   J. Immunol. 168 (6), 2857-2864 (2002)
   PUBMED   11884455
  REMARK    GeneRIF: Binding of Sp1 to the 5' end Sp1-I site is critical for
            maximal activity of the Fc gamma RIIIA promoter Pmed1, which
            directs NK/T cell-specific expression of heterologous genes.
REFERENCE   92 (bases 1 to 7667)
  AUTHORS   Xu,Y., Porntadavity,S. and St Clair,D.K.
  TITLE     Transcriptional regulation of the human manganese superoxide
            dismutase gene: the role of specificity protein 1 (Sp1) and
            activating protein-2 (AP-2)
  JOURNAL   Biochem. J. 362 (Pt 2), 401-412 (2002)
   PUBMED   11853549
  REMARK    GeneRIF: AP-2 down-regulates transcription of the human SOD2 gene
            via its interaction with Sp1 within the promoter region.
REFERENCE   93 (bases 1 to 7667)
  AUTHORS   Chen,B.K., Tsai,T.Y., Huang,H.S., Chen,L.C., Chang,W.C., Tsai,S.B.
            and Chang,W.C.
  TITLE     Functional role of extracellular signal-regulated kinase activation
            and c-Jun induction in phorbol ester-induced promoter activation of
            human 12(S)-lipoxygenase gene
  JOURNAL   J. Biomed. Sci. 9 (2), 156-165 (2002)
   PUBMED   11914583
  REMARK    GeneRIF: Enhancement of binding between the c-Jun-Sp1 complex and
            the Sp1 oligonucleotide was observed in cells treated with PMA,
            suggesting the possible interaction of c-Jun-Sp1 with GC-rich
            binding sites in the 12(S)-lipoxygenase gene promoter.
REFERENCE   94 (bases 1 to 7667)
  AUTHORS   Steger,G., Schnabel,C. and Schmidt,H.M.
  TITLE     The hinge region of the human papillomavirus type 8 E2 protein
            activates the human p21(WAF1/CIP1) promoter via interaction with
            Sp1
  JOURNAL   J. Gen. Virol. 83 (Pt 3), 503-510 (2002)
   PUBMED   11842244
  REMARK    GeneRIF: hinge region of the human papillomavirus type 8 E2 protein
            activates the human p21(WAF1/CIP1) promoter via interaction with
            Sp1
REFERENCE   95 (bases 1 to 7667)
  AUTHORS   Hata,Y., Kominato,Y., Yamamoto,F.I. and Takizawa,H.
  TITLE     Characterization of the human ABO gene promoter in erythroid cell
            lineage
  JOURNAL   Vox Sang. 82 (1), 39-46 (2002)
   PUBMED   11856466
  REMARK    GeneRIF: The expression of the ABO promoter is influenced by the
            binding of transcription factor Sp1 or Sp1-like protein(s) in both
            erythroid and epithelial cell lineages.
REFERENCE   96 (bases 1 to 7667)
  AUTHORS   Serio,K.J., Hodulik,C.R. and Bigby,T.D.
  TITLE     Regulation of leukotriene C4 synthase gene expression by SP1 and
            SP3 in mononuclear phagocytes
  JOURNAL   Adv. Exp. Med. Biol. 507, 61-66 (2002)
   PUBMED   12664565
  REMARK    GeneRIF: Regulates leukotreiene C4 synthase gene expression in
            mononuclear phagocytes.
REFERENCE   97 (bases 1 to 7667)
  AUTHORS   Nicolas,M., Noe,V., Jensen,K.B. and Ciudad,C.J.
  TITLE     Cloning and characterization of the 5'-flanking region of the human
            transcription factor Sp1 gene
  JOURNAL   J. Biol. Chem. 276 (25), 22126-22132 (2001)
   PUBMED   11294852
REFERENCE   98 (bases 1 to 7667)
  AUTHORS   Xu,Q., Ji,Y.S. and Schmedtje,J.F. Jr.
  TITLE     Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular
            endothelium. Implications for the mechanisms of aortic aneurysm and
            heart failure
  JOURNAL   J. Biol. Chem. 275 (32), 24583-24589 (2000)
   PUBMED   10825178
REFERENCE   99 (bases 1 to 7667)
  AUTHORS   Stoner,M., Wang,F., Wormke,M., Nguyen,T., Samudio,I., Vyhlidal,C.,
            Marme,D., Finkenzeller,G. and Safe,S.
  TITLE     Inhibition of vascular endothelial growth factor expression in
            HEC1A endometrial cancer cells through interactions of estrogen
            receptor alpha and Sp3 proteins
  JOURNAL   J. Biol. Chem. 275 (30), 22769-22779 (2000)
   PUBMED   10816575
REFERENCE   100 (bases 1 to 7667)
  AUTHORS   Korner,K. and Muller,R.
  TITLE     In vivo structure of the cell cycle-regulated human cdc25C promoter
  JOURNAL   J. Biol. Chem. 275 (25), 18676-18681 (2000)
   PUBMED   10747986
REFERENCE   101 (bases 1 to 7667)
  AUTHORS   Zhang,J.L., Sharma,P.L. and Crumpacker,C.S.
  TITLE     Enhancement of the basal-level activity of HIV-1 long terminal
            repeat by HIV-1 nucleocapsid protein
  JOURNAL   Virology 268 (2), 251-263 (2000)
   PUBMED   10704334
REFERENCE   102 (bases 1 to 7667)
  AUTHORS   Lim,S.P. and Garzino-Demo,A.
  TITLE     The human immunodeficiency virus type 1 Tat protein up-regulates
            the promoter activity of the beta-chemokine monocyte
            chemoattractant protein 1 in the human astrocytoma cell line U-87
            MG: role of SP-1, AP-1, and NF-kappaB consensus sites
  JOURNAL   J. Virol. 74 (4), 1632-1640 (2000)
   PUBMED   10644332
REFERENCE   103 (bases 1 to 7667)
  AUTHORS   Rohr,O., Schwartz,C., Hery,C., Aunis,D., Tardieu,M. and
            Schaeffer,E.
  TITLE     The nuclear receptor chicken ovalbumin upstream promoter
            transcription factor interacts with HIV-1 Tat and stimulates viral
            replication in human microglial cells
  JOURNAL   J. Biol. Chem. 275 (4), 2654-2660 (2000)
   PUBMED   10644726
REFERENCE   104 (bases 1 to 7667)
  AUTHORS   Chen,F., Lu,Y., Castranova,V., Rojanasakul,Y., Miyahara,K.,
            Shizuta,Y., Vallyathan,V., Shi,X. and Demers,L.M.
  TITLE     Nitric oxide inhibits HIV tat-induced NF-kappaB activation
  JOURNAL   Am. J. Pathol. 155 (1), 275-284 (1999)
   PUBMED   10393859
REFERENCE   105 (bases 1 to 7667)
  AUTHORS   Fogel,S., Guittaut,M., Legrand,A., Monsigny,M. and Hebert,E.
  TITLE     The tat protein of HIV-1 induces galectin-3 expression
  JOURNAL   Glycobiology 9 (4), 383-387 (1999)
   PUBMED   10089212
REFERENCE   106 (bases 1 to 7667)
  AUTHORS   Karantzoulis-Fegaras,F., Antoniou,H., Lai,S.L., Kulkarni,G.,
            D'Abreo,C., Wong,G.K., Miller,T.L., Chan,Y., Atkins,J., Wang,Y. and
            Marsden,P.A.
  TITLE     Characterization of the human endothelial nitric-oxide synthase
            promoter
  JOURNAL   J. Biol. Chem. 274 (5), 3076-3093 (1999)
   PUBMED   9915847
REFERENCE   107 (bases 1 to 7667)
  AUTHORS   Seve,M., Favier,A., Osman,M., Hernandez,D., Vaitaitis,G.,
            Flores,N.C., McCord,J.M. and Flores,S.C.
  TITLE     The human immunodeficiency virus-1 Tat protein increases cell
            proliferation, alters sensitivity to zinc chelator-induced
            apoptosis, and changes Sp1 DNA binding in HeLa cells
  JOURNAL   Arch. Biochem. Biophys. 361 (2), 165-172 (1999)
   PUBMED   9882443
REFERENCE   108 (bases 1 to 7667)
  AUTHORS   Sawaya,B.E., Khalili,K., Mercer,W.E., Denisova,L. and Amini,S.
  TITLE     Cooperative actions of HIV-1 Vpr and p53 modulate viral gene
            transcription
  JOURNAL   J. Biol. Chem. 273 (32), 20052-20057 (1998)
   PUBMED   9685344
REFERENCE   109 (bases 1 to 7667)
  AUTHORS   El Kharroubi,A., Piras,G., Zensen,R. and Martin,M.A.
  TITLE     Transcriptional activation of the integrated chromatin-associated
            human immunodeficiency virus type 1 promoter
  JOURNAL   Mol. Cell. Biol. 18 (5), 2535-2544 (1998)
   PUBMED   9566873
REFERENCE   110 (bases 1 to 7667)
  AUTHORS   Chun,R.F., Semmes,O.J., Neuveut,C. and Jeang,K.T.
  TITLE     Modulation of Sp1 phosphorylation by human immunodeficiency virus
            type 1 Tat
  JOURNAL   J. Virol. 72 (4), 2615-2629 (1998)
   PUBMED   9525578
REFERENCE   111 (bases 1 to 7667)
  AUTHORS   Sawaya,B.E., Khalili,K. and Amini,S.
  TITLE     Transcription of the human immunodeficiency virus type 1 (HIV-1)
            promoter in central nervous system cells: effect of YB-1 on
            expression of the HIV-1 long terminal repeat
  JOURNAL   J. Gen. Virol. 79 (Pt 2), 239-246 (1998)
   PUBMED   9472608
REFERENCE   112 (bases 1 to 7667)
  AUTHORS   Rohr,O., Aunis,D. and Schaeffer,E.
  TITLE     COUP-TF and Sp1 interact and cooperate in the transcriptional
            activation of the human immunodeficiency virus type 1 long terminal
            repeat in human microglial cells
  JOURNAL   J. Biol. Chem. 272 (49), 31149-31155 (1997)
   PUBMED   9388268
REFERENCE   113 (bases 1 to 7667)
  AUTHORS   Xiao,H., Lis,J.T. and Jeang,K.T.
  TITLE     Promoter activity of Tat at steps subsequent to TATA-binding
            protein recruitment
  JOURNAL   Mol. Cell. Biol. 17 (12), 6898-6905 (1997)
   PUBMED   9372921
REFERENCE   114 (bases 1 to 7667)
  AUTHORS   Razik,M.A., Lee,K., Price,R.R., Williams,M.R., Ongjoco,R.R.,
            Dole,M.K., Rudner,X.L., Kwatra,M.M. and Schwinn,D.A.
  TITLE     Transcriptional regulation of the human alpha1a-adrenergic receptor
            gene. Characterization Of the 5'-regulatory and promoter region
  JOURNAL   J. Biol. Chem. 272 (45), 28237-28246 (1997)
   PUBMED   9353275
REFERENCE   115 (bases 1 to 7667)
  AUTHORS   Cujec,T.P., Cho,H., Maldonado,E., Meyer,J., Reinberg,D. and
            Peterlin,B.M.
  TITLE     The human immunodeficiency virus transactivator Tat interacts with
            the RNA polymerase II holoenzyme
  JOURNAL   Mol. Cell. Biol. 17 (4), 1817-1823 (1997)
   PUBMED   9121429
REFERENCE   116 (bases 1 to 7667)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Tat-SF1: cofactor for stimulation of transcriptional elongation by
            HIV-1 Tat
  JOURNAL   Science 274 (5287), 605-610 (1996)
   PUBMED   8849451
REFERENCE   117 (bases 1 to 7667)
  AUTHORS   Agostini,I., Navarro,J.M., Rey,F., Bouhamdan,M., Spire,B., Vigne,R.
            and Sire,J.
  TITLE     The human immunodeficiency virus type 1 Vpr transactivator:
            cooperation with promoter-bound activator domains and binding to
            TFIIB
  JOURNAL   J. Mol. Biol. 261 (5), 599-606 (1996)
   PUBMED   8800208
REFERENCE   118 (bases 1 to 7667)
  AUTHORS   Blau,J., Xiao,H., McCracken,S., O'Hare,P., Greenblatt,J. and
            Bentley,D.
  TITLE     Three functional classes of transcriptional activation domain
  JOURNAL   Mol. Cell. Biol. 16 (5), 2044-2055 (1996)
   PUBMED   8628270
REFERENCE   119 (bases 1 to 7667)
  AUTHORS   Wang,L., Mukherjee,S., Jia,F., Narayan,O. and Zhao,L.J.
  TITLE     Interaction of virion protein Vpr of human immunodeficiency virus
            type 1 with cellular transcription factor Sp1 and trans-activation
            of viral long terminal repeat
  JOURNAL   J. Biol. Chem. 270 (43), 25564-25569 (1995)
   PUBMED   7592727
REFERENCE   120 (bases 1 to 7667)
  AUTHORS   Sune,C. and Garcia-Blanco,M.A.
  TITLE     Sp1 transcription factor is required for in vitro basal and
            Tat-activated transcription from the human immunodeficiency virus
            type 1 long terminal repeat
  JOURNAL   J. Virol. 69 (10), 6572-6576 (1995)
   PUBMED   7666561
REFERENCE   121 (bases 1 to 7667)
  AUTHORS   Howcroft,T.K., Palmer,L.A., Brown,J., Rellahan,B., Kashanchi,F.,
            Brady,J.N. and Singer,D.S.
  TITLE     HIV Tat represses transcription through Sp1-like elements in the
            basal promoter
  JOURNAL   Immunity 3 (1), 127-138 (1995)
   PUBMED   7621073
REFERENCE   122 (bases 1 to 7667)
  AUTHORS   Zhang,R., Min,W. and Sessa,W.C.
  TITLE     Functional analysis of the human endothelial nitric oxide synthase
            promoter. Sp1 and GATA factors are necessary for basal
            transcription in endothelial cells
  JOURNAL   J. Biol. Chem. 270 (25), 15320-15326 (1995)
   PUBMED   7541039
  REMARK    GeneRIF: The Sp1 transcription factor interacts with the human eNOS
            promoter at a region which includes a putative Sp1 site (-104 to
            -95). This interaction activates eNOS transcription.
REFERENCE   123 (bases 1 to 7667)
  AUTHORS   Duan,L., Ozaki,I., Oakes,J.W., Taylor,J.P., Khalili,K. and
            Pomerantz,R.J.
  TITLE     The tumor suppressor protein p53 strongly alters human
            immunodeficiency virus type 1 replication
  JOURNAL   J. Virol. 68 (7), 4302-4313 (1994)
   PUBMED   8207805
REFERENCE   124 (bases 1 to 7667)
  AUTHORS   Huang,L.M. and Jeang,K.T.
  TITLE     Increased spacing between Sp1 and TATAA renders human
            immunodeficiency virus type 1 replication defective: implication
            for Tat function
  JOURNAL   J. Virol. 67 (12), 6937-6944 (1993)
   PUBMED   8230415
REFERENCE   125 (bases 1 to 7667)
  AUTHORS   Kamine,J., Subramanian,T. and Chinnadurai,G.
  TITLE     Activation of a heterologous promoter by human immunodeficiency
            virus type 1 Tat requires Sp1 and is distinct from the mode of
            activation by acidic transcriptional activators
  JOURNAL   J. Virol. 67 (11), 6828-6834 (1993)
   PUBMED   8411386
REFERENCE   126 (bases 1 to 7667)
  AUTHORS   Jeang,K.T., Chun,R., Lin,N.H., Gatignol,A., Glabe,C.G. and Fan,H.
  TITLE     In vitro and in vivo binding of human immunodeficiency virus type 1
            Tat protein and Sp1 transcription factor
  JOURNAL   J. Virol. 67 (10), 6224-6233 (1993)
   PUBMED   7690421
REFERENCE   127 (bases 1 to 7667)
  AUTHORS   Matera,A.G. and Ward,D.C.
  TITLE     Localization of the human Sp1 transcription factor gene to 12q13 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 17 (3), 793-794 (1993)
   PUBMED   8244404
REFERENCE   128 (bases 1 to 7667)
  AUTHORS   Kamine,J. and Chinnadurai,G.
  TITLE     Synergistic activation of the human immunodeficiency virus type 1
            promoter by the viral Tat protein and cellular transcription factor
            Sp1
  JOURNAL   J. Virol. 66 (6), 3932-3936 (1992)
   PUBMED   1583736
REFERENCE   129 (bases 1 to 7667)
  AUTHORS   Kamine,J., Subramanian,T. and Chinnadurai,G.
  TITLE     Sp1-dependent activation of a synthetic promoter by human
            immunodeficiency virus type 1 Tat protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (19), 8510-8514 (1991)
   PUBMED   1924310
REFERENCE   130 (bases 1 to 7667)
  AUTHORS   Szpirer,J., Szpirer,C., Riviere,M., Levan,G., Marynen,P.,
            Cassiman,J.J., Wiese,R. and DeLuca,H.F.
  TITLE     The Sp1 transcription factor gene (SP1) and the
            1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on
            human chromosome arm 12q and rat chromosome 7
  JOURNAL   Genomics 11 (1), 168-173 (1991)
   PUBMED   1662663
REFERENCE   131 (bases 1 to 7667)
  AUTHORS   Courey,A.J., Holtzman,D.A., Jackson,S.P. and Tjian,R.
  TITLE     Synergistic activation by the glutamine-rich domains of human
            transcription factor Sp1
  JOURNAL   Cell 59 (5), 827-836 (1989)
   PUBMED   2512012
REFERENCE   132 (bases 1 to 7667)
  AUTHORS   Harrich,D., Garcia,J., Wu,F., Mitsuyasu,R., Gonazalez,J. and
            Gaynor,R.
  TITLE     Role of SP1-binding domains in in vivo transcriptional regulation
            of the human immunodeficiency virus type 1 long terminal repeat
  JOURNAL   J. Virol. 63 (6), 2585-2591 (1989)
   PUBMED   2657100
REFERENCE   133 (bases 1 to 7667)
  AUTHORS   Jackson,S.P. and Tjian,R.
  TITLE     O-glycosylation of eukaryotic transcription factors: implications
            for mechanisms of transcriptional regulation
  JOURNAL   Cell 55 (1), 125-133 (1988)
   PUBMED   3139301
REFERENCE   134 (bases 1 to 7667)
  AUTHORS   Kadonaga,J.T., Carner,K.R., Masiarz,F.R. and Tjian,R.
  TITLE     Isolation of cDNA encoding transcription factor Sp1 and functional
            analysis of the DNA binding domain
  JOURNAL   Cell 51 (6), 1079-1090 (1987)
   PUBMED   3319186
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from BQ072120.1, AF255682.1,
            BC043224.1, BF434304.1, BQ774060.1, BC012008.1, BM463205.1,
            CD104746.1, BF436290.1, BQ431320.1, BF671559.1, AL442093.1 and
            AI282745.1.
            On or before Jan 26, 2004 this sequence version replaced
            gi:41201705, gi:19924004.
FEATURES             Location/Qualifiers
     source          1..7667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.1"
     gene            1..7667
                     /gene="SP1"
                     /db_xref="GeneID:6667"
                     /db_xref="MIM:189906"
     CDS             98..2455
                     /gene="SP1"
                     /note="go_component: nucleus [goid 0005634] [evidence
                     NAS];
                     go_function: DNA binding [goid 0003677] [evidence IEA];
                     go_function: zinc ion binding [goid 0008270] [evidence
                     IEA];
                     go_function: transcriptional activator activity [goid
                     0016563] [evidence NAS];
                     go_function: RNA polymerase II transcription factor
                     activity [goid 0003702] [evidence NAS] [pmid 3139301];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence NAS]"
                     /codon_start=1
                     /product="Sp1 transcription factor"
                     /protein_id="NP_612482.2"
                     /db_xref="GI:38372901"
                     /db_xref="GeneID:6667"
                     /db_xref="MIM:189906"
                     /translation="MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTG
                     SSSSTGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQ
                     GANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQV
                     LTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNR
                     GSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAAT
                     LTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTS
                     NMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQ
                     QTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPII
                     IRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASA
                     ASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLG
                     LHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKK
                     QHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTG
                     EKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATP
                     SALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF"
ORIGIN      
        1 gtccgggttc gcttgcctcg tcagcgtccg cgtttttccc ggcccccccc aacccccccg
       61 gacaggaccc ccttgagctt gtccctcagc tgccaccatg agcgaccaag atcactccat
      121 ggatgaaatg acagctgtgg tgaaaattga aaaaggagtt ggtggcaata atgggggcaa
      181 tggtaatggt ggtggtgcct tttcacaggc tcgaagtagc agcacaggca gtagcagcag
      241 cactggagga ggagggcagg agtcccagcc atcccctttg gctctgctgg cagcaacttg
      301 cagcagaatt gagtcaccca atgagaacag caacaactcc cagggcccga gtcagtcagg
      361 gggaacaggt gagcttgacc tcacagccac acaactttca cagggtgcca atggctggca
      421 gatcatctct tcctcctctg gggctacccc tacctcaaag gaacagagtg gcagcagtac
      481 caatggcagc aatggcagtg agtcttccaa gaatcgcaca gtctctggtg ggcagtatgt
      541 tgtggctgcc gctcccaact tacagaacca gcaagttctg acaggactac ctggagtgat
      601 gcctaatatt cagtatcaag taatcccaca gttccagacc gttgatgggc aacagctgca
      661 gtttgctgcc actggggccc aagtgcagca ggatggttct ggtcaaatac agatcatacc
      721 aggtgcaaac caacagatta tcacaaatcg aggaagtgga ggcaacatca ttgctgctat
      781 gccaaaccta ctccagcagg ctgtccccct ccaaggcctg gctaataatg tactctcagg
      841 acagactcag tatgtgacca atgtaccagt ggccctgaat gggaacatca ccttgctacc
      901 tgtcaacagc gtttctgcag ctaccttgac tcccagctct caggcagtca cgatcagcag
      961 ctctgggtcc caggagagtg gctcacagcc tgtcacctca gggactacca tcagttctgc
     1021 cagcttggta tcatcacaag ccagttccag ctcctttttc accaatgcca atagctactc
     1081 aactactact accaccagca acatgggaat tatgaacttt actaccagtg gatcatcagg
     1141 gaccaactct caaggccaga caccccagag ggtcagtggg ctacaggggt ctgatgctct
     1201 gaacatccag caaaaccaga catctggagg ctcattgcaa gcaggccagc aaaaagaagg
     1261 agagcaaaac cagcagacac agcagcaaca aattcttatc cagcctcagc tagttcaagg
     1321 gggacaggcc ctccaggccc tccaagcagc accattgtca gggcagacct ttacaactca
     1381 agccatctcc caggaaaccc tccagaacct ccagcttcag gctgttccaa actctggtcc
     1441 catcatcatc cggacaccaa cagtggggcc caatggacag gtcagttggc agactctaca
     1501 gctgcagaac ctccaagttc agaacccaca agcccaaaca atcaccttag ccccaatgca
     1561 gggtgtttcc ttggggcaga ccagcagcag caacaccact ctcacaccca ttgcctcagc
     1621 tgcttccatt cctgctggca cagtcactgt gaatgctgct caactctcct ccatgccagg
     1681 cctccagacc attaacctca gtgcattggg tacttcagga atccaggtgc acccaattca
     1741 aggcctgccg ttggctatag caaatgcccc aggtgatcat ggagctcagc ttggtctcca
     1801 tggggctggt ggtgatggaa tacatgatga cacagcaggt ggagaggaag gagaaaacag
     1861 cccagatgcc caaccccaag ccggtcggag gacccggcgg gaagcatgca cctgccccta
     1921 ctgtaaagac agtgaaggaa ggggctcggg ggatcctggc aaaaagaaac agcatatttg
     1981 ccacatccaa ggctgtggga aagtgtatgg caagacctct cacctgcggg cacacttgcg
     2041 ctggcataca ggcgagaggc catttatgtg tacctggtca tactgtggga aacgcttcac
     2101 acgttcggat gagctacaga ggcacaaacg tacacacaca ggtgagaaga aatttgcctg
     2161 ccctgagtgt cctaagcgct tcatgaggag tgaccacctg tcaaaacata tcaagaccca
     2221 ccagaataag aagggaggcc caggtgtagc tctgagtgtg ggcactttgc ccctggacag
     2281 tggggcaggt tcagaaggca gtggcactgc cactccttca gcccttatta ccaccaatat
     2341 ggtagccatg gaggccatct gtccagaggg cattgcccgt cttgccaaca gtggcatcaa
     2401 cgtcatgcag gtggcagatc tgcagtccat taatatcagt ggcaatggct tctgagatca
     2461 ggcacccggg gccagagaca tatgggccat accccttaac cccgggatgc aaggtagcat
     2521 gggtccaaga gacatggaag agagagccat gaagcattaa aatgcatggt gttgagaaga
     2581 atcaggagag ggatacaaga gaggagatgg ggtcccggca cccatctgta tcatcagtgc
     2641 ctctttgaag gtgggaaaca ttagtgaaaa ttctgttggt gccacgcttt gatgagcatt
     2701 tgtttgaccc cagtttcttc ttacacttct taccccagcc tacccttcct gcatttctct
     2761 tctcagctct tccatgatgg attccccccc ctttcctaaa gccatcatgc cttgataaat
     2821 atatatgatc attgaaatac tttttaacaa aaaacagatt ctatattatt atatatatat
     2881 atatatatat aaagatatat agagatgcat tcacaggggt tggctgggag gaggaagacc
     2941 attctgtgac caaaatacct tggtcatttt ttttatattg ccttatttcc ctatggctga
     3001 gccttgttgt gacacatcaa gcttttctgt agatgttgtc ttggcttccc accagcttaa
     3061 gcgttcatat gctctgcttt tagttcatat atacatacat aatgtttttc ctttcttaat
     3121 tttgtctttt tgtttgggat cagcttcttg cactccttcc ctaactcaac tgttgccgtc
     3181 tcatcttctc tcatctgatc acttcatgtt ttgtttttgt tactgcctgg atgaggcact
     3241 tctgtcaatt ttttcaggac cttagttcca gcagcagaat ggaaaaatcc ttgaagccca
     3301 ggctgatgct tgaagtaact gtggagggag tgttcaaaat actactgacg caggcacctt
     3361 cttggcgctg gagagtcaaa ggcatctccc ttcattagct gctctgagca tcaagaatta
     3421 gaagtctttc agtggaattg tacaagagtc cctttgaaga taataatctt ggctcagttt
     3481 gtataaactg tcaaattttc aaataatagg tagggggctt tcactaggaa aatcatgtgc
     3541 tcagaagagg aaatgactcg tagtcaggtt caggagttag tggagtattt ggactttggt
     3601 actgctgtct tccaaggtag ctctaagttt tgatgtgtgg gcttctgagt ttatattctg
     3661 aaaggaaata cacttctttt gaacatcccc actaggttct tttccattgt caataaggag
     3721 catcagccag tgaatctgtt tcaggtttcc attctgcaga actcctccaa agcatgtgct
     3781 agtggcaaga cagtggttct tatgatgttt tcccttaact tttccttgta tgttcttggg
     3841 tggttcctaa gggaaaggga agcacatgat catgggaatg atagcccaga acaaaaagaa
     3901 atcttgtctt accacagtgt tttataggag agattgggag aaatcatcct gttttctctg
     3961 tgacctgatt tcagaagaga ctgatccaaa aattataacg gcagggaacc tagtgcattt
     4021 ggcactgaga tttaaatgca accagaattg tcctcaaggc ccagccataa aagcattgtc
     4081 tctctcgacc ttctggtatc ttgttagaga gcttttcact gtgaggaagt gtggaaaaat
     4141 agctctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtaatctgtt aggttgggga
     4201 taggttttct gctagccaat attaaaagag acctgcaata aaaaaattac cctgatctga
     4261 tagaaagcaa gtgtttttgt atgtgtgggt gaatgtgtgt tcatgcccgt atatgtctac
     4321 acacagatga caaattatat ttgaaatcgt tggaaaataa attcagatca aaatgccttt
     4381 caggcccatt acctagaaat ctatcttaaa acctgggtat gttcctaagg tcatttcttt
     4441 gcttatgcta aattaattac aattatgaat ggaggatatt ctactgtact tttttaaaaa
     4501 gaaactattt ttgtgtttga aagtgaaacc aacatccaga tctatagcag agtccttatt
     4561 cttctcataa atctttttac tttggctaca aatagatgat ggtatgattc tattatatat
     4621 tttatataaa atccatccaa attaagtttt gggtaagtgt gttgtttaat ctgaactata
     4681 gtaacttaat actctaaaca atagttcact ccatttggtc ctttctccac agatgtaatt
     4741 atgttttcaa ctcaggaact atggcaagga actttcccca gatcaaattc tattaacgct
     4801 gagatacaag tcatccatgc acagccacta tcataccctt tattctcact gaaaggcaga
     4861 actcagaacc tgttatttta tgtctgtaat catgtacttt ggcatctttt ggaggaaagg
     4921 ggcaggataa ctcactggaa tgtacagtat tttgctagtg catttcaagg aatggaatct
     4981 tctccagtat gaaattacca gatataaaat aatgtaatga tgctgaggat ataagctttt
     5041 agaaggtaat ttgatggtat ttctttctcg aatgaaaagc tgctggttta ccctcaaccc
     5101 tattcattag cattaccatg agtgaattta tatctaatta tttccacttg ccctgttctc
     5161 ttcacaccaa ggaagctcca gatccagtat cttgtttggc ctcaaaacag aagcagcttc
     5221 ttttgtctcc cagcagtagt gagccactca gtctcttcca caggaagttt ggagcctaca
     5281 ttccttgagt caggagctta ttacagaaaa accccgtttc cctgaacttt tggctaacag
     5341 aaattaattt aactgacatg catattgatt ctgaaatttt tttcctaagt ttttttcatt
     5401 tttttgaatg agttttttaa attttttaga tgaccaaaac ttgcagggca ggggatgccc
     5461 agaagagtgg tgagatagta aaacacttat tccctcatcc tttcaggttt tcaggttgcc
     5521 catttatatt catttacatg tcatttgact gtctcacttt ttacccagaa cagtaacaac
     5581 ccacaccgtc ttccttcagg gatttccaac tggcactctg tgggtgctac acagaatgca
     5641 atttaatgga tatttctcag cctggttcag aataaattga tcctttgatc ccagaaagta
     5701 tatactgaag tgtgggataa agattatgat taggggaggg ttggagacaa aagctgtaaa
     5761 ttactatggc tgatttattt ctactatata catatatatt ttttgctttt gtatatccta
     5821 tataggaaac taagcattgt atttttttta acaaatctaa aaaagcacta tgaactacag
     5881 gtgtttgact ttcaaaatat attttgtatt gttaatatct tcacattgtg tgaatactgg
     5941 aagctgcaga tctttgctag gacgcaataa atttatatac tttttgaggg gttcttctgg
     6001 ggtgctaatc aggcccctgt tatgcttagg gggagccctg gtgctacttg cttgaagttt
     6061 tcagtgtaag taccctgatg ccttttggac cttgggatca gatcaagagt tttggagatc
     6121 aggtaccaag gaaataagga cagtctagct gcctcaagtg aggggccctt tgcatagctc
     6181 tccttccccc tcactgaagc tgggtagcct attggggttg agagggaaaa tgtgaaatct
     6241 cagaatttat ctcccttaga agagagccag taacttatgt acaaggatga aagaaaggtc
     6301 gcagcagtag ctttggggaa agggaggaag atatggcact tctccaaccc cggaaaacat
     6361 tgcttttgaa aactgctgat aaaatatgag ccggttatta cttctgtttg ggagactgtg
     6421 ctctctgtgg tgcctctctt ggctctactc cacagatacc agacctcttc taagaggatg
     6481 agcagaccag ctttgaggtt gacctgtttc tctttgtctg ccttcccaaa acaccagccc
     6541 ccaggaagac attaagcagc cttaagctta aattcctact ccctcttcca aatttggctc
     6601 acttgcctta gatccaaggc agggaaagga aaagaagggg ggtctctggc tttattactc
     6661 ccctaagtct ttactctgac ttccccaaac ccagaaagat tttctccaca gtgttcattt
     6721 gaaagaggag tattttgtcc cattttcccc ttcctcatta tcaaacagcc ccagtcttcc
     6781 ttgtctctgc taagaaagta gaggcatgat gatctgcctc tcaactgccc taagtcctag
     6841 ctaagtatca ggggaaaaaa aaaaaaaaaa agcctaacaa atgggattag actagggctg
     6901 caagtagtga ggattttgtt gatacctctg ctgggatgtg tgctttccca tatcttgcct
     6961 tcaggaatta cactgtgcct tttccccagg gatatgggct ctgtctaccc agtgctccag
     7021 tttcccggta actgctcttg aacattgtgg acaagggcag gtcttcatat ttttgatcat
     7081 ccctttctcc cagtgaaatc ccatagccct tacctagagt ctagggcaca aagacttcgg
     7141 ggaagataca ctgagattga cctgaggaga catctacaca caccagtggc agctgcccca
     7201 gggcctgctt ccccttccta agtctgtcat cctctggaag ggatgggtgg tgctccaatc
     7261 tctggtgcct aaaaacccaa gtttatttct ctcttaacac tggcaataac cagtccacac
     7321 cactgttgcc ttttaaaacc tcttaataat ctcatgctgt gtttgttttg attccaatcc
     7381 aattatcacc agggctgtgt gggtaaatgc ttttaaatgc tctctcatct tgttcttccc
     7441 cctcaccccc cactcttagg tatgtatgat gctaatcttg tccctaagta agtttcttcc
     7501 tgctcctttt gtatcttcct ttcttgtctt tcctcctacc ttttgtctct tggtgttttg
     7561 ggactttttt tttttttttt ttggcctttt gtacaaagat tagtttcaat gtagtctgta
     7621 gcctcctttg taaaccaatt aaaaagtttt ttaataaaaa aaaaaaa
//

LOCUS       NM_138785               1143 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens chromosome 6 open reading frame 72 (C6orf72), mRNA.
ACCESSION   NM_138785
VERSION     NM_138785.1  GI:20302037
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1143)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC014320.1.
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1143
                     /gene="C6orf72"
                     /note="synonym: dJ12G14.2"
                     /db_xref="GeneID:116254"
     CDS             28..1020
                     /gene="C6orf72"
                     /codon_start=1
                     /product="chromosome 6 open reading frame 72"
                     /protein_id="NP_620140.1"
                     /db_xref="GI:20302038"
                     /db_xref="GeneID:116254"
                     /translation="MEGAPPGSLALRLLLFVALPASGWLTTGAPEPPPLSGAPQDGIR
                     INVTTLKDDGDISKQQVVLNITYESGQVYVNDLPVNSGVTRISCQTLIVKNENLENLE
                     EKEYFGIVSVRILVHEWPMTSGSSLQLIVIQEEVVEIDGKQVQQKDVTEIDILVKNRG
                     VLRHSNYTLPLEESMLYSISRDSDILFTLPNLSKKESVSSLQTTSQYLIRNVETTVDE
                     DVLPGKLPETPLRAEPPSSYKVMCQWMEKFRKDLCRFWSNVFPVFFQFLNIMVVGITG
                     AAVVITILKVFFPVSEYKGILQLDKVDVIPVTAINLYPDGPEKRAENLEDKTCI"
ORIGIN      
        1 gggggccctc tgcccgggtt gtccaagatg gagggcgctc caccggggtc gctcgccctc
       61 cggctcctgc tgttcgtggc gctacccgcc tccggctggc tgacgacggg cgcccccgag
      121 ccgccgccgc tgtccggagc cccacaggac ggcatcagaa ttaatgtaac tacactgaaa
      181 gatgatgggg acatatctaa acagcaggtt gttcttaaca taacctatga gagtggacag
      241 gtgtatgtaa atgacttacc tgtaaatagt ggtgtaaccc gaataagctg tcagactttg
      301 atagtgaaga atgaaaatct tgaaaatttg gaggaaaaag aatattttgg aattgtcagt
      361 gtaaggattt tagttcatga gtggcctatg acatctggtt ccagtttgca actaattgtc
      421 attcaagaag aggtagtaga gattgatgga aaacaagttc agcaaaagga tgtcactgaa
      481 attgatattt tagttaagaa ccggggagta ctcagacatt caaactatac cctccctttg
      541 gaagaaagca tgctctactc tatttctcga gacagtgaca ttttatttac ccttcctaac
      601 ctctccaaaa aagaaagtgt tagttcactg caaaccacta gccagtatct tatcaggaat
      661 gtggaaacca ctgtagatga agatgtttta cctggcaagt tacctgaaac tcctctcaga
      721 gcagagccgc catcttcata taaggtaatg tgtcagtgga tggaaaagtt tagaaaagat
      781 ctgtgtaggt tctggagcaa cgttttccca gtattctttc agtttttgaa catcatggtg
      841 gttggaatta caggagcagc tgtggtaata accatcttaa aggtgttttt cccagtttct
      901 gaatacaaag gaattcttca gttggataaa gtggacgtca tacctgtgac agctatcaac
      961 ttatatccag atggtccaga gaaaagagct gaaaaccttg aagataaaac atgtatttaa
     1021 aacgccatct catatcatgg actccgaagt agcctgttgc ctccaaattt gccacttgaa
     1081 tataattttc tttaaatcgt taagaatcag tttcaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aaa
//

LOCUS       NM_139012               3757 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens mitogen-activated protein kinase 14 (MAPK14),
            transcript variant 2, mRNA.
ACCESSION   NM_139012
VERSION     NM_139012.1  GI:20986511
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3757)
  AUTHORS   Aleman,M., Schierloh,P., de la Barrera,S.S., Musella,R.M.,
            Saab,M.A., Baldini,M., Abbate,E. and Sasiain,M.C.
  TITLE     Mycobacterium tuberculosis triggers apoptosis in peripheral
            neutrophils involving toll-like receptor 2 and p38 mitogen protein
            kinase in tuberculosis patients
  JOURNAL   Infect. Immun. 72 (9), 5150-5158 (2004)
   PUBMED   15322009
  REMARK    GeneRIF: Apoptosis of neutrophils from patients with active TB is
            induced by the interaction with the whole M. tuberculosis via
            Toll-like receptor 2 (TLR2), and involves the p38 mitogen-activated
            protein kinase (MAPK) pathway
REFERENCE   2  (bases 1 to 3757)
  AUTHORS   Jans,R., Atanasova,G., Jadot,M. and Poumay,Y.
  TITLE     Cholesterol depletion upregulates involucrin expression in
            epidermal keratinocytes through activation of p38
  JOURNAL   J. Invest. Dermatol. 123 (3), 564-573 (2004)
   PUBMED   15304097
  REMARK    GeneRIF: cholesterol depletion alters involucrin gene expression
            through activation of p38alpha/beta.
REFERENCE   3  (bases 1 to 3757)
  AUTHORS   Undevia,N.S., Dorscheid,D.R., Marroquin,B.A., Gugliotta,W.L.,
            Tse,R. and White,S.R.
  TITLE     Smad and p38-MAPK signaling mediates apoptotic effects of
            transforming growth factor-beta1 in human airway epithelial cells
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 287 (3), L515-L524 (2004)
   PUBMED   15132952
  REMARK    GeneRIF: dual signaling pathways involving TGF-beta1, an
            antiapoptotic pathway mediated by the Smad pathway involving p21,
            and an apoptosis-permissive pathway mediated in part by p38 MAPK.
REFERENCE   4  (bases 1 to 3757)
  AUTHORS   Nakagawa,S., Ohtani,T., Mizuashi,M., Mollah,Z.U., Ito,Y., Tagami,H.
            and Aiba,S.
  TITLE     p38 Mitogen-Activated protein kinase mediates dual role of
            ultraviolet B radiation in induction of maturation and apoptosis of
            monocyte-derived dendritic cells
  JOURNAL   J. Invest. Dermatol. 123 (2), 361-370 (2004)
   PUBMED   15245437
  REMARK    GeneRIF: dual effect of UVB, to stimulate maturation or to induce
            apoptosis in monocyte derived dendritic cells, depending on the
            dosage, via p38 MAPK pathway.
REFERENCE   5  (bases 1 to 3757)
  AUTHORS   Abecassis,L., Rogier,E., Vazquez,A., Atfi,A. and Bourgeade,M.F.
  TITLE     Evidence for a role of MSK1 in transforming growth
            factor-beta-mediated responses through p38alpha and Smad signaling
            pathways
  JOURNAL   J. Biol. Chem. 279 (29), 30474-30479 (2004)
   PUBMED   15133024
  REMARK    GeneRIF: p38alpha and Smad signaling pathways have roles in
            MSK1-mediated transforming growth factor-beta-mediated responses
REFERENCE   6  (bases 1 to 3757)
  AUTHORS   Santos,L.L., Lacey,D., Yang,Y., Leech,M. and Morand,E.F.
  TITLE     Activation of synovial cell p38 MAP kinase by macrophage migration
            inhibitory factor
  JOURNAL   J. Rheumatol. 31 (6), 1038-1043 (2004)
   PUBMED   15170913
  REMARK    GeneRIF: MIF activates rheumatoid arthritis COX-2 and IL-6
            expression via p38 MAP kinase activation and induces IL-8 via p38
            and ERK MAP kinase-independent pathways.
REFERENCE   7  (bases 1 to 3757)
  AUTHORS   Alvarado-Kristensson,M., Melander,F., Leandersson,K.,
            Ronnstrand,L., Wernstedt,C. and Andersson,T.
  TITLE     p38-MAPK signals survival by phosphorylation of caspase-8 and
            caspase-3 in human neutrophils
  JOURNAL   J. Exp. Med. 199 (4), 449-458 (2004)
   PUBMED   14970175
  REMARK    GeneRIF: p38-MAPK can directly phosphorylate and inhibit the
            activities of caspase-8 and caspase-3 and thereby hinder neutrophil
            apoptosis, and, in so doing, regulate the inflammatory response.
REFERENCE   8  (bases 1 to 3757)
  AUTHORS   Bendotti,C., Atzori,C., Piva,R., Tortarolo,M., Strong,M.J.,
            DeBiasi,S. and Migheli,A.
  TITLE     Activated p38MAPK is a novel component of the intracellular
            inclusions found in human amyotrophic lateral sclerosis and mutant
            SOD1 transgenic mice
  JOURNAL   J. Neuropathol. Exp. Neurol. 63 (2), 113-119 (2004)
   PUBMED   14989597
  REMARK    GeneRIF: activation of p38MAPK might contribute significantly to
            the pathology of motor neurons in ALS.
REFERENCE   9  (bases 1 to 3757)
  AUTHORS   Li,Y., Sassano,A., Majchrzak,B., Deb,D.K., Levy,D.E., Gaestel,M.,
            Nebreda,A.R., Fish,E.N. and Platanias,L.C.
  TITLE     Role of p38alpha Map kinase in Type I interferon signaling
  JOURNAL   J. Biol. Chem. 279 (2), 970-979 (2004)
   PUBMED   14578350
  REMARK    GeneRIF: p38alpha regulates activation of downstream effectors that
            participate in the induction of IFN-dependent gene transcription to
            mediate IFN-responses
REFERENCE   10 (bases 1 to 3757)
  AUTHORS   Lee,J., Shin,J.S., Park,J.Y., Kwon,D., Choi,S.J., Kim,S.J. and
            Choi,I.H.
  TITLE     p38 mitogen-activated protein kinase modulates expression of tumor
            necrosis factor-related apoptosis-inducing ligand induced by
            interferon-gamma in fetal brain astrocytes
  JOURNAL   J. Neurosci. Res. 74 (6), 884-890 (2003)
   PUBMED   14648593
  REMARK    GeneRIF: p38 MAPK modulates STAT1 phosphorylation in IFN-gamma
            signaling in fetal brain astrocytes.
REFERENCE   11 (bases 1 to 3757)
  AUTHORS   Kobayashi,H., Aiba,S., Yoshino,Y. and Tagami,H.
  TITLE     Acute cutaneous barrier disruption activates epidermal p44/42 and
            p38 mitogen-activated protein kinases in human and hairless guinea
            pig skin
  JOURNAL   Exp. Dermatol. 12 (6), 734-746 (2003)
   PUBMED   14714552
  REMARK    GeneRIF: epidermal p44/42 and p38 mitogen-activated protein kinases
            are activated by acute cutaneous barrier disruption
REFERENCE   12 (bases 1 to 3757)
  AUTHORS   Karsdal,M.A., Hjorth,P., Henriksen,K., Kirkegaard,T., Nielsen,K.L.,
            Lou,H., Delaisse,J.M. and Foged,N.T.
  TITLE     Transforming growth factor-beta controls human osteoclastogenesis
            through the p38 MAPK and regulation of RANK expression
  JOURNAL   J. Biol. Chem. 278 (45), 44975-44987 (2003)
   PUBMED   12933809
  REMARK    GeneRIF: transforming growth factor-beta promotes
            osteoclastogenesis in monocytes by stimulation of the p38 mitogen
            activated protein kinase but continuous exposure abrogates
            osteoclastogenesis by down-regulation of receptor activator of
            NF-KB(RANK) expression
REFERENCE   13 (bases 1 to 3757)
  AUTHORS   Cheung,P.C., Campbell,D.G., Nebreda,A.R. and Cohen,P.
  TITLE     Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
  JOURNAL   EMBO J. 22 (21), 5793-5805 (2003)
   PUBMED   14592977
  REMARK    GeneRIF: TAB1 participates in a SAPK2a/p38alpha-mediated feedback
            control of TAK1
REFERENCE   14 (bases 1 to 3757)
  AUTHORS   Dean,J.L., Sarsfield,S.J., Tsounakou,E. and Saklatvala,J.
  TITLE     p38 Mitogen-activated protein kinase stabilizes mRNAs that contain
            cyclooxygenase-2 and tumor necrosis factor AU-rich elements by
            inhibiting deadenylation
  JOURNAL   J. Biol. Chem. 278 (41), 39470-39476 (2003)
   PUBMED   12882963
  REMARK    GeneRIF: p38 MAPK pathway predominantly regulates deadenylation,
            rather than decay of the mRNA body
REFERENCE   15 (bases 1 to 3757)
  AUTHORS   Sun,A., Liu,M., Nguyen,X.V. and Bing,G.
  TITLE     P38 MAP kinase is activated at early stages in Alzheimer's disease
            brain
  JOURNAL   Exp. Neurol. 183 (2), 394-405 (2003)
   PUBMED   14552880
  REMARK    GeneRIF: p38 MAPK is activated at early stages of neurofibrillary
            degeneration in AD hippocampus. The p38 activation may also be
            linked to neurodegeneration through mechanisms other than
            neurofibrillary tangle formation
REFERENCE   16 (bases 1 to 3757)
  AUTHORS   Yustein,J.T., Xia,L., Kahlenburg,J.M., Robinson,D., Templeton,D.
            and Kung,H.J.
  TITLE     Comparative studies of a new subfamily of human Ste20-like kinases:
            homodimerization, subcellular localization, and selective
            activation of MKK3 and p38
  JOURNAL   Oncogene 22 (40), 6129-6141 (2003)
   PUBMED   13679851
  REMARK    GeneRIF: p38 is selectively activated by the new subfamily of
            Ste20-like kinases.
REFERENCE   17 (bases 1 to 3757)
  AUTHORS   Yu,Y., Zeng,H., Lyons,S., Carlson,A., Merlin,D., Neish,A.S. and
            Gewirtz,A.T.
  TITLE     TLR5-mediated activation of p38 MAPK regulates epithelial IL-8
            expression via posttranscriptional mechanism
  JOURNAL   Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2), G282-G290
            (2003)
   PUBMED   12702497
  REMARK    GeneRIF: results indicate that epithelial TLR5 mediates p38
            activation and subsequently regulates flagellin-induced IL-8
            expression independently of NF-kappaB, probably by influencing IL-8
            mRNA translation
REFERENCE   18 (bases 1 to 3757)
  AUTHORS   Zhang,J., Li,W., Sumpio,B.E. and Basson,M.D.
  TITLE     Fibronectin blocks p38 and jnk activation by cyclic strain in
            Caco-2 cells
  JOURNAL   Biochem. Biophys. Res. Commun. 306 (3), 746-749 (2003)
   PUBMED   12810082
  REMARK    GeneRIF: Results suggest that tissue or plasma fibronectin may
            modulate the intestinal epithelial response to repetitive
            deformation through inhibted activation of p38 and jun kinases.
REFERENCE   19 (bases 1 to 3757)
  AUTHORS   Tan,Y., Yu,R. and Pezzuto,J.M.
  TITLE     Betulinic acid-induced programmed cell death in human melanoma
            cells involves mitogen-activated protein kinase activation
  JOURNAL   Clin. Cancer Res. 9 (7), 2866-2875 (2003)
   PUBMED   12855667
  REMARK    GeneRIF: p38 has a role in apoptosis in human melanoma cells by
            modulating depolarization of mitochondrial membrane potential
REFERENCE   20 (bases 1 to 3757)
  AUTHORS   Iyoda,K., Sasaki,Y., Horimoto,M., Toyama,T., Yakushijin,T.,
            Sakakibara,M., Takehara,T., Fujimoto,J., Hori,M., Wands,J.R. and
            Hayashi,N.
  TITLE     Involvement of the p38 mitogen-activated protein kinase cascade in
            hepatocellular carcinoma
  JOURNAL   Cancer 97 (12), 3017-3026 (2003)
   PUBMED   12784337
  REMARK    GeneRIF: These findings suggested that reduction of the p38 MAPK
            cascade may account, in part, for the resistance to apoptosis,
            leading to the unrestricted cell growth of human HCC.
REFERENCE   21 (bases 1 to 3757)
  AUTHORS   Sharma,G.D., He,J. and Bazan,H.E.
  TITLE     p38 and ERK1/2 coordinate cellular migration and proliferation in
            epithelial wound healing: evidence of cross-talk activation between
            MAP kinase cascades
  JOURNAL   J. Biol. Chem. 278 (24), 21989-21997 (2003)
   PUBMED   12663671
  REMARK    GeneRIF: p38 and ERK1/2 have roles in coordinating cellular
            migration and proliferation in epithelial wound healing
REFERENCE   22 (bases 1 to 3757)
  AUTHORS   Malcolm,K.C. and Worthen,G.S.
  TITLE     Lipopolysaccharide stimulates p38-dependent induction of antiviral
            genes in neutrophils independently of paracrine factors
  JOURNAL   J. Biol. Chem. 278 (18), 15693-15701 (2003)
   PUBMED   12595530
  REMARK    GeneRIF: Lipopolysaccharide stimulates p38-dependent induction of
            antiviral genes , such as myxovirus resistance-1 (MX1) in
            neutrophils independently of paracrine factors.
REFERENCE   23 (bases 1 to 3757)
  AUTHORS   Tamagno,E., Robino,G., Obbili,A., Bardini,P., Aragno,M., Parola,M.
            and Danni,O.
  TITLE     H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal
            apoptosis by activating JNKs and p38MAPK
  JOURNAL   Exp. Neurol. 180 (2), 144-155 (2003)
   PUBMED   12684028
REFERENCE   24 (bases 1 to 3757)
  AUTHORS   Kaur,J., Woodman,R.C. and Kubes,P.
  TITLE     P38 MAPK: critical molecule in thrombin-induced NF-kappa
            B-dependent leukocyte recruitment
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 284 (4), H1095-H1103 (2003)
   PUBMED   12505871
  REMARK    GeneRIF: data suggest that thrombin induces p38 mitogen-activated
            protein kinase activation, which leads to NF-kappa B mobilization
            to the nucleus and causes the upregulation of E-selectin and
            subsequent leukocyte recruitment
REFERENCE   25 (bases 1 to 3757)
  AUTHORS   Xu,Z.G., Kim,K.S., Park,H.C., Choi,K.H., Lee,H.Y., Han,D.S. and
            Kang,S.W.
  TITLE     High glucose activates the p38 MAPK pathway in cultured human
            peritoneal mesothelial cells
  JOURNAL   Kidney Int. 63 (3), 958-968 (2003)
   PUBMED   12631076
  REMARK    GeneRIF: activated p38 MAPK pathway may play a role in the
            pathogenesis of peritoneal fibrosis.
REFERENCE   26 (bases 1 to 3757)
  AUTHORS   Carlson,C.J., Koterski,S., Sciotti,R.J., Poccard,G.B. and
            Rondinone,C.M.
  TITLE     Enhanced basal activation of mitogen-activated protein kinases in
            adipocytes from type 2 diabetes: potential role of p38 in the
            downregulation of GLUT4 expression
  JOURNAL   Diabetes 52 (3), 634-641 (2003)
   PUBMED   12606502
  REMARK    GeneRIF: upregulation of the p38 mitogen-activated protein kinase
            pathway might contribute to the loss of GLUT4 protein expression
            observed in adipose tissue from type 2 diabetic patients
REFERENCE   27 (bases 1 to 3757)
  AUTHORS   Kang,H.J., Soh,Y., Kim,M.S., Lee,E.J., Surh,Y.J., Kim,H.R.,
            Kim,S.H. and Moon,A.
  TITLE     Roles of JNK-1 and p38 in selective induction of apoptosis by
            capsaicin in ras-transformed human breast epithelial cells
  JOURNAL   Int. J. Cancer 103 (4), 475-482 (2003)
   PUBMED   12478662
  REMARK    GeneRIF: JNK-1 and p38 play a role in apoptosis induced by
            capsaicin in H-ras-transformed tumor cells
REFERENCE   28 (bases 1 to 3757)
  AUTHORS   Iwasa,H., Han,J. and Ishikawa,F.
  TITLE     Mitogen-activated protein kinase p38 defines the common
            senescence-signalling pathway
  JOURNAL   Genes Cells 8 (2), 131-144 (2003)
   PUBMED   12581156
  REMARK    GeneRIF: p38 mitogen-activated protein kinase defines the common
            senescence-signaling pathway.
REFERENCE   29 (bases 1 to 3757)
  AUTHORS   Ge,B., Xiong,X., Jing,Q., Mosley,J.L., Filose,A., Bian,D., Huang,S.
            and Han,J.
  TITLE     TAB1beta (transforming growth factor-beta-activated protein kinase
            1-binding protein 1beta), a novel splicing variant of TAB1 that
            interacts with p38alpha but not TAK1
  JOURNAL   J. Biol. Chem. 278 (4), 2286-2293 (2003)
   PUBMED   12429732
  REMARK    GeneRIF: p38 alpha is regulated by TauAlphaBeta1beta in
            physiological conditions
REFERENCE   30 (bases 1 to 3757)
  AUTHORS   Wu,D. and Cederbaum,A.I.
  TITLE     Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity
  JOURNAL   J. Biol. Chem. 278 (2), 1115-1124 (2003)
   PUBMED   12403788
REFERENCE   31 (bases 1 to 3757)
  AUTHORS   Frevel,M.A., Bakheet,T., Silva,A.M., Hissong,J.G., Khabar,K.S. and
            Williams,B.R.
  TITLE     p38 Mitogen-activated protein kinase-dependent and -independent
            signaling of mRNA stability of AU-rich element-containing
            transcripts
  JOURNAL   Mol. Cell. Biol. 23 (2), 425-436 (2003)
   PUBMED   12509443
  REMARK    GeneRIF: p38 MAP kinase is involved in a positive feedback loop
            regulating macrophage signaling with MKK6
REFERENCE   32 (bases 1 to 3757)
  AUTHORS   Sheth,K., Friel,J., Nolan,B., Miller-Graziano,C. and Bankey,P.
  TITLE     Down-regulated circulating PMN function after injury despite
            enhanced p38 MAPK activity
  JOURNAL   Surg Infect (Larchmt) 3 (2), 151-157 (2002)
   PUBMED   12519482
  REMARK    GeneRIF: p38 signaling is down-regulated in postinjury circulating
            neutrophils
REFERENCE   33 (bases 1 to 3757)
  AUTHORS   Lim,S., Zou,Y. and Friedman,E.
  TITLE     The transcriptional activator Mirk/Dyrk1B is sequestered by
            p38alpha/beta MAP kinase
  JOURNAL   J. Biol. Chem. 277 (51), 49438-49445 (2002)
   PUBMED   12384504
  REMARK    GeneRIF: p38 MAP Kinase suppresses the function of Mirk as a
            transcriptional activator only when cells are proliferating
REFERENCE   34 (bases 1 to 3757)
  AUTHORS   D'Addario,M., Arora,P.D., Ellen,R.P. and McCulloch,C.A.
  TITLE     Interaction of p38 and Sp1 in a mechanical force-induced, beta 1
            integrin-mediated transcriptional circuit that regulates the
            actin-binding protein filamin-A
  JOURNAL   J. Biol. Chem. 277 (49), 47541-47550 (2002)
   PUBMED   12324467
  REMARK    GeneRIF: there is a mechanically coupled transcriptional circuit
            that activates p38, tethers p38 to actin filaments, and promotes
            binding of p38 to Sp1 in the nucleus
REFERENCE   35 (bases 1 to 3757)
  AUTHORS   Kondoh,M., Tasaki,E., Araragi,S., Takiguchi,M., Higashimoto,M.,
            Watanabe,Y. and Sato,M.
  TITLE     Requirement of caspase and p38MAPK activation in zinc-induced
            apoptosis in human leukemia HL-60 cells
  JOURNAL   Eur. J. Biochem. 269 (24), 6204-6211 (2002)
   PUBMED   12473116
  REMARK    GeneRIF: p38MAPK and caspase are required for zinc-induced
            apoptosis in human leukemia HL-60 cells
REFERENCE   36 (bases 1 to 3757)
  AUTHORS   Bachelor,M.A., Silvers,A.L. and Bowden,G.T.
  TITLE     The role of p38 in UVA-induced cyclooxygenase-2 expression in the
            human keratinocyte cell line, HaCaT
  JOURNAL   Oncogene 21 (46), 7092-7099 (2002)
   PUBMED   12370831
  REMARK    GeneRIF: p38 play a critical role in the UVA-induced expression of
            COX-2 in keratinocytes and may serve as a potential drug target in
            the chemoprevention of skin cancer.
REFERENCE   37 (bases 1 to 3757)
  AUTHORS   Ramsauer,K., Sadzak,I., Porras,A., Pilz,A., Nebreda,A.R., Decker,T.
            and Kovarik,P.
  TITLE     p38 MAPK enhances STAT1-dependent transcription independently of
            Ser-727 phosphorylation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (20), 12859-12864 (2002)
   PUBMED   12232043
  REMARK    GeneRIF: p38 MAPK has a role in STAT1 dependent trans activation
            independent of serine phosphorylation
REFERENCE   38 (bases 1 to 3757)
  AUTHORS   Carneiro-Santos,P., Alves-Oliveira,L.F., Correa-Oliveira,R. and
            Hagan,P.
  TITLE     P38 mitogen-activated protein kinase influence on the production of
            IL-10 in human schistosomiasis mansoni
  JOURNAL   Parasite Immunol. 24 (9-10), 493-497 (2002)
   PUBMED   12654092
  REMARK    GeneRIF: p38 MAPK activation is central to IL-10 production of
            cells from patients with schistosomiasis mansoni and the levels of
            phosphorylated p38 MAPK influences the amount of Il-10 produced in
            cells from intestinal and hepatosplenic patients
REFERENCE   39 (bases 1 to 3757)
  AUTHORS   Blaschke,F., Stawowy,P., Goetze,S., Hintz,O., Grafe,M.,
            Kintscher,U., Fleck,E. and Graf,K.
  TITLE     Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase
            in human vascular smooth muscle cells
  JOURNAL   Biochem. Biophys. Res. Commun. 296 (4), 890-896 (2002)
   PUBMED   12200131
  REMARK    GeneRIF: ITGB1 activated by ERK1/2, p38 MAPK after hypoxia
REFERENCE   40 (bases 1 to 3757)
  AUTHORS   van Gorp,R.M., Heeneman,S., Broers,J.L., Bronnenberg,N.M., van
            Dam-Mieras,M.C. and Heemskerk,J.W.
  TITLE     Glutathione oxidation in calcium- and p38 MAPK-dependent membrane
            blebbing of endothelial cells
  JOURNAL   Biochim. Biophys. Acta 1591 (1-3), 129-138 (2002)
   PUBMED   12183063
  REMARK    GeneRIF: both Ca(2+)-dependent and p38 kinase-mediated
            phosphorylation events, causes reassembly of the actin cytoskeleton
            and subsequent appearance of membrane blebs at the plasma membrane.
REFERENCE   41 (bases 1 to 3757)
  AUTHORS   Uchi,H., Arrighi,J.F., Aubry,J.P., Furue,M. and Hauser,C.
  TITLE     The sesquiterpene lactone parthenolide inhibits LPS- but not
            TNF-alpha-induced maturation of human monocyte-derived dendritic
            cells by inhibition of the p38 mitogen-activated protein kinase
            pathway
  JOURNAL   J. Allergy Clin. Immunol. 110 (2), 269-276 (2002)
   PUBMED   12170268
  REMARK    GeneRIF: parthenolide inhibits LPS- but not TNF-alpha-induced
            maturation of human monocyte-derived dendritic cells by inhibition
            of the p38 mitogen-activated protein kinase pathway
REFERENCE   42 (bases 1 to 3757)
  AUTHORS   Shim,M.J., Kim,H.J., Yang,S.J., Lee,I.S., Choi,H.I. and Kim,T.
  TITLE     Arsenic trioxide induces apoptosis in chronic myelogenous leukemia
            K562 cells: possible involvement of p38 MAP kinase
  JOURNAL   J. Biochem. Mol. Biol. 35 (4), 377-383 (2002)
   PUBMED   12296996
  REMARK    GeneRIF: As(2)O(3) is able to induce the apoptotic activity in K562
            cells, and its apoptotic mechanism may be associated with the
            activation of p38.
REFERENCE   43 (bases 1 to 3757)
  AUTHORS   Neve,R.M., Holbro,T. and Hynes,N.E.
  TITLE     Distinct roles for phosphoinositide 3-kinase, mitogen-activated
            protein kinase and p38 MAPK in mediating cell cycle progression of
            breast cancer cells
  JOURNAL   Oncogene 21 (29), 4567-4576 (2002)
   PUBMED   12085235
  REMARK    GeneRIF: Distinct roles for phosphoinositide 3-kinase,
            mitogen-activated protein kinase and p38 MAPK in mediating cell
            cycle progression of breast cancer cells.
REFERENCE   44 (bases 1 to 3757)
  AUTHORS   Chouinard,N., Valerie,K., Rouabhia,M. and Huot,J.
  TITLE     UVB-mediated activation of p38 mitogen-activated protein kinase
            enhances resistance of normal human keratinocytes to apoptosis by
            stabilizing cytoplasmic p53
  JOURNAL   Biochem. J. 365 (Pt 1), 133-145 (2002)
   PUBMED   12071847
  REMARK    GeneRIF: UVB-mediated activation of p38 mitogen-activated protein
            kinase enhances resistance of normal human keratinocytes to
            apoptosis by stabilizing cytoplasmic p53.
REFERENCE   45 (bases 1 to 3757)
  AUTHORS   Brand,P., Plochmann,S., Valk,E., Zahn,S., Saloga,J., Knop,J. and
            Becker,D.
  TITLE     Activation and translocation of p38 mitogen-activated protein
            kinase after stimulation of monocytes with contact sensitizers
  JOURNAL   J. Invest. Dermatol. 119 (1), 99-106 (2002)
   PUBMED   12164931
  REMARK    GeneRIF: activation of this stress-associated pathway has been
            reported for many stimuli, a unique translocation of p38 from the
            cytoplasm to the detergent-resistant fraction is a specific event
            during hapten-induced activation of antigen-presenting cells.
REFERENCE   46 (bases 1 to 3757)
  AUTHORS   Wong,C.K., Zhang,J.P., Ip,W.K. and Lam,C.W.
  TITLE     Activation of p38 mitogen-activated protein kinase and nuclear
            factor-kappaB in tumour necrosis factor-induced eotaxin release of
            human eosinophils
  JOURNAL   Clin. Exp. Immunol. 128 (3), 483-489 (2002)
   PUBMED   12067303
  REMARK    GeneRIF: Activation of p38 mitogen-activated protein kinase and
            nuclear factor-kappaB in tumour necrosis factor-induced eotaxin
            release of human eosinophils.
REFERENCE   47 (bases 1 to 3757)
  AUTHORS   Jung,Y.D., Fan,F., McConkey,D.J., Jean,M.E., Liu,W., Reinmuth,N.,
            Stoeltzing,O., Ahmad,S.A., Parikh,A.A., Mukaida,N. and Ellis,L.M.
  TITLE     Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced
            IL-8 expression in human vascular smooth muscle cells
  JOURNAL   Cytokine 18 (4), 206-213 (2002)
   PUBMED   12126643
  REMARK    GeneRIF: P38 MAPK has a role in inducing IL-8 gene transcription
            via AP-1 activation in hVSMCs
REFERENCE   48 (bases 1 to 3757)
  AUTHORS   Waetzig,G.H., Seegert,D., Rosenstiel,P., Nikolaus,S. and
            Schreiber,S.
  TITLE     p38 mitogen-activated protein kinase is activated and linked to
            TNF-alpha signaling in inflammatory bowel disease
  JOURNAL   J. Immunol. 168 (10), 5342-5351 (2002)
   PUBMED   11994493
  REMARK    GeneRIF: p38alpha MAP kinase is significantly activated in the
            inflamed colonic mucosa of Crohn's disease patients and is linked
            to the induction of TNF-alpha secretion and signaling in this
            system.
REFERENCE   49 (bases 1 to 3757)
  AUTHORS   Liacini,A., Sylvester,J., Li,W.Q. and Zafarullah,M.
  TITLE     Inhibition of interleukin-1-stimulated MAP kinases, activating
            protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B)
            transcription factors down-regulates matrix metalloproteinase gene
            expression in articular chondrocytes
  JOURNAL   Matrix Biol. 21 (3), 251-262 (2002)
   PUBMED   12009331
  REMARK    GeneRIF: involvement of P38 MAPK, AP-1 and NF-kappa B transcription
            factors in the IL-1 induction of MMPs in chondrocytes
REFERENCE   50 (bases 1 to 3757)
  AUTHORS   Pargellis,C., Tong,L., Churchill,L., Cirillo,P.F., Gilmore,T.,
            Graham,A.G., Grob,P.M., Hickey,E.R., Moss,N., Pav,S. and Regan,J.
  TITLE     Inhibition of p38 MAP kinase by utilizing a novel allosteric
            binding site
  JOURNAL   Nat. Struct. Biol. 9 (4), 268-272 (2002)
   PUBMED   11896401
  REMARK    GeneRIF: allosteric binding site for a diaryl urea class of highly
            potent and selective inhibitors against human p38 MAP kinase
REFERENCE   51 (bases 1 to 3757)
  AUTHORS   Sudo,T., Yagasaki,Y., Hama,H., Watanabe,N. and Osada,H.
  TITLE     Exip, a new alternative splicing variant of p38 alpha, can induce
            an earlier onset of apoptosis in HeLa cells
  JOURNAL   Biochem. Biophys. Res. Commun. 291 (4), 838-843 (2002)
   PUBMED   11866441
REFERENCE   52 (bases 1 to 3757)
  AUTHORS   Verma,A., Deb,D.K., Sassano,A., Uddin,S., Varga,J., Wickrema,A. and
            Platanias,L.C.
  TITLE     Activation of the p38 mitogen-activated protein kinase mediates the
            suppressive effects of type I interferons and transforming growth
            factor-beta on normal hematopoiesis
  JOURNAL   J. Biol. Chem. 277 (10), 7726-7735 (2002)
   PUBMED   11773065
  REMARK    GeneRIF: p38 Map kinase pathway is a common effector for type I IFN
            and transforming growth factor beta signaling in human
            hematopoietic progenitors and plays a critical role in the
            induction of the suppressive effects of these cytokines on normal
            hematopoiesis
REFERENCE   53 (bases 1 to 3757)
  AUTHORS   Laprise,P., Chailler,P., Houde,M., Beaulieu,J.F., Boucher,M.J. and
            Rivard,N.
  TITLE     Phosphatidylinositol 3-kinase controls human intestinal epithelial
            cell differentiation by promoting adherens junction assembly and
            p38 MAPK activation
  JOURNAL   J. Biol. Chem. 277 (10), 8226-8234 (2002)
   PUBMED   11756422
  REMARK    GeneRIF: PI3K promotes assembly of adherens junctions, which, in
            turn, control p38 MAPK activation and enterocyte differentiation.
REFERENCE   54 (bases 1 to 3757)
  AUTHORS   Ge,B., Gram,H., Di Padova,F., Huang,B., New,L., Ulevitch,R.J.,
            Luo,Y. and Han,J.
  TITLE     MAPKK-independent activation of p38alpha mediated by TAB1-dependent
            autophosphorylation of p38alpha
  JOURNAL   Science 295 (5558), 1291-1294 (2002)
   PUBMED   11847341
REFERENCE   55 (bases 1 to 3757)
  AUTHORS   Lee,M.W., Park,S.C., Yang,Y.G., Yim,S.O., Chae,H.S., Bach,J.H.,
            Lee,H.J., Kim,K.Y., Lee,W.B. and Kim,S.S.
  TITLE     The involvement of reactive oxygen species (ROS) and p38
            mitogen-activated protein (MAP) kinase in TRAIL/Apo2L-induced
            apoptosis
  JOURNAL   FEBS Lett. 512 (1-3), 313-318 (2002)
   PUBMED   11852102
  REMARK    GeneRIF: TRAIL/Apo2L-induced apoptosis is mediated by ROS-activated
            p38 MAP kinase followed by caspase activation in HeLa cells.
REFERENCE   56 (bases 1 to 3757)
  AUTHORS   Thellung,S., Villa,V., Corsaro,A., Arena,S., Millo,E., Damonte,G.,
            Benatti,U., Tagliavini,F., Florio,T. and Schettini,G.
  TITLE     p38 MAP kinase mediates the cell death induced by PrP106-126 in the
            SH-SY5Y neuroblastoma cells
  JOURNAL   Neurobiol. Dis. 9 (1), 69-81 (2002)
   PUBMED   11848686
  REMARK    GeneRIF: mediates the cell death induced by PrP106-126
REFERENCE   57 (bases 1 to 3757)
  AUTHORS   Rizzo,M.T., Pudlo,N., Farrell,L. and Leaver,A.
  TITLE     Specificity of arachidonic acid-induced inhibition of growth and
            activation of c-jun kinases and p38 mitogen-activated protein
            kinase in hematopoietic cells
  JOURNAL   Prostaglandins Leukot. Essent. Fatty Acids 66 (1), 31-40 (2002)
   PUBMED   12051955
  REMARK    GeneRIF: Specificity of arachidonic acid-induced inhibition of
            growth and activation of c-jun kinases and p38 mitogen-activated
            protein kinase in hematopoietic cells
REFERENCE   58 (bases 1 to 3757)
  AUTHORS   van den Blink,B., Branger,J., Weijer,S., Deventer,S.H., van der
            Poll,T. and Peppelenbosch,M.P.
  TITLE     Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase,
            but not c-Jun N-terminal kinase
  JOURNAL   Mol. Med. 7 (11), 755-760 (2001)
   PUBMED   11788789
  REMARK    GeneRIF: endotoxemia induced a phosphorylation and activation of
            p38 MAPK
REFERENCE   59 (bases 1 to 3757)
  AUTHORS   De Zutter,G.S. and Davis,R.J.
  TITLE     Pro-apoptotic gene expression mediated by the p38 mitogen-activated
            protein kinase signal transduction pathway
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (11), 6168-6173 (2001)
   PUBMED   11344273
REFERENCE   60 (bases 1 to 3757)
  AUTHORS   Bulavin,D.V., Higashimoto,Y., Popoff,I.J., Gaarde,W.A., Basrur,V.,
            Potapova,O., Appella,E. and Fornace,A.J. Jr.
  TITLE     Initiation of a G2/M checkpoint after ultraviolet radiation
            requires p38 kinase
  JOURNAL   Nature 411 (6833), 102-107 (2001)
   PUBMED   11333986
REFERENCE   61 (bases 1 to 3757)
  AUTHORS   Tamura,K., Sudo,T., Senftleben,U., Dadak,A.M., Johnson,R. and
            Karin,M.
  TITLE     Requirement for p38alpha in erythropoietin expression: a role for
            stress kinases in erythropoiesis
  JOURNAL   Cell 102 (2), 221-231 (2000)
   PUBMED   10943842
REFERENCE   62 (bases 1 to 3757)
  AUTHORS   Sanz,V., Arozarena,I. and Crespo,P.
  TITLE     Distinct carboxy-termini confer divergent characteristics to the
            mitogen-activated protein kinase p38alpha and its splice isoform
            Mxi2
  JOURNAL   FEBS Lett. 474 (2-3), 169-174 (2000)
   PUBMED   10838079
REFERENCE   63 (bases 1 to 3757)
  AUTHORS   Bulavin,D.V., Saito,S., Hollander,M.C., Sakaguchi,K.,
            Anderson,C.W., Appella,E. and Fornace,A.J. Jr.
  TITLE     Phosphorylation of human p53 by p38 kinase coordinates N-terminal
            phosphorylation and apoptosis in response to UV radiation
  JOURNAL   EMBO J. 18 (23), 6845-6854 (1999)
   PUBMED   10581258
REFERENCE   64 (bases 1 to 3757)
  AUTHORS   Takenaka,K., Moriguchi,T. and Nishida,E.
  TITLE     Activation of the protein kinase p38 in the spindle assembly
            checkpoint and mitotic arrest
  JOURNAL   Science 280 (5363), 599-602 (1998)
   PUBMED   9554853
REFERENCE   65 (bases 1 to 3757)
  AUTHORS   Zervos,A.S., Faccio,L., Gatto,J.P., Kyriakis,J.M. and Brent,R.
  TITLE     Mxi2, a mitogen-activated protein kinase that recognizes and
            phosphorylates Max protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (23), 10531-10534 (1995)
   PUBMED   7479834
REFERENCE   66 (bases 1 to 3757)
  AUTHORS   McDonnell,P.C., DiLella,A.G., Lee,J.C. and Young,P.R.
  TITLE     Localization of the human stress responsive MAP kinase-like CSAIDs
            binding protein (CSBP) gene to chromosome 6q21.3/21.2
  JOURNAL   Genomics 29 (1), 301-302 (1995)
   PUBMED   8530093
REFERENCE   67 (bases 1 to 3757)
  AUTHORS   Han,J., Richter,B., Li,Z., Kravchenko,V. and Ulevitch,R.J.
  TITLE     Molecular cloning of human p38 MAP kinase
  JOURNAL   Biochim. Biophys. Acta 1265 (2-3), 224-227 (1995)
   PUBMED   7696354
REFERENCE   68 (bases 1 to 3757)
  AUTHORS   Lee,J.C., Laydon,J.T., McDonnell,P.C., Gallagher,T.F., Kumar,S.,
            Green,D., McNulty,D., Blumenthal,M.J., Heys,J.R., Landvatter,S.W.
            et al.
  TITLE     A protein kinase involved in the regulation of inflammatory
            cytokine biosynthesis
  JOURNAL   Nature 372 (6508), 739-746 (1994)
   PUBMED   7997261
REFERENCE   69 (bases 1 to 3757)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ. 4 (10), 821-830 (1993)
   PUBMED   8274451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000092.1 and L35263.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase is activated by various
            environmental stresses and proinflammatory cytokines. The
            activation requires its phosphorylation by MAP kinase kinases
            (MKKs), or its autophosphorylation triggered by the interaction of
            MAP3K7IP1/TAB1 protein with this kinase. The substrates of this
            kinase include transcription regulator ATF2, MEF2C, and MAX, cell
            cycle regulator CDC25B, and tumor suppressor p53, which suggest the
            roles of this kinase in stress related transcription and cell cycle
            regulation, as well as in genotoxic stress response. Four
            alternatively spliced transcript variants of this gene encoding
            distinct isoforms have been reported.
            
            Transcript Variant: This variant (2) contains a different segment
            within the coding region when compared to variant 1. The
            translation frame remains the same, and the resulting isoform 2 has
            an internal segment different from that of isoform 1.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3-p21.2"
     gene            1..3757
                     /gene="MAPK14"
                     /note="synonyms: RK, p38, EXIP, Mxi2, CSBP1, CSBP2, CSPB1,
                     PRKM14, PRKM15, SAPK2A, p38ALPHA"
                     /db_xref="GeneID:1432"
                     /db_xref="MIM:600289"
     CDS             363..1445
                     /gene="MAPK14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Csaids binding protein; cytokine suppressive
                     anti-inflammatory drug binding protein; MAP kinase Mxi2;
                     p38 mitogen activated protein kinase; p38 MAP kinase;
                     p38alpha Exip; stress-activated protein kinase 2A;
                     MAX-interacting protein 2;
                     go_component: nucleus [goid 0005634] [evidence ISS];
                     go_component: cytoplasm [goid 0005737] [evidence ISS];
                     go_function: ATP binding [goid 0005524] [evidence IEA];
                     go_function: MAP kinase activity [goid 0004707] [evidence
                     IEA];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: MP kinase activity [goid 0008339] [evidence
                     IDA] [pmid 7997261];
                     go_function: MAP kinase kinase activity [goid 0004708]
                     [evidence TAS] [pmid 10706854];
                     go_function: protein-tyrosine kinase activity [goid
                     0004713] [evidence IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence IEA];
                     go_process: chemotaxis [goid 0006935] [evidence TAS] [pmid
                     10706854];
                     go_process: cell motility [goid 0006928] [evidence TAS]
                     [pmid 10912793];
                     go_process: response to stress [goid 0006950] [evidence
                     IDA] [pmid 7997261];
                     go_process: protein kinase cascade [goid 0007243]
                     [evidence IDA] [pmid 10838079];
                     go_process: protein amino acid phosphorylation [goid
                     0006468] [evidence IEA];
                     go_process: cell surface receptor linked signal
                     transduction [goid 0007166] [evidence TAS] [pmid
                     10706854];
                     go_process: antimicrobial humoral response (sensu
                     Vertebrata) [goid 0019735] [evidence TAS] [pmid 7997261]"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 14 isoform 2"
                     /protein_id="NP_620581.1"
                     /db_xref="GI:20986512"
                     /db_xref="GeneID:1432"
                     /db_xref="MIM:600289"
                     /translation="MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT
                     KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV
                     YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
                     DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT
                     GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG
                     ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLI
                     DEWKSLTYDEVISFVPPPLDQEEMES"
     misc_feature    1050..1124
                     /gene="MAPK14"
                     /note="Region: the internal coding region different from
                     variant 1"
     polyA_signal    2844..2849
                     /gene="MAPK14"
     polyA_site      2874
                     /gene="MAPK14"
                     /evidence=experimental
     polyA_signal    3735..3740
                     /gene="MAPK14"
     polyA_site      3757
                     /gene="MAPK14"
                     /evidence=experimental
ORIGIN      
        1 ggaaccgcga ccactggagc cttagcgggc gcagcagctg gaacgggagt actgcgacgc
       61 agcccggagt cggccttgta ggggcgaagg tgcagggaga tcgcggcggg cgcagtcttg
      121 agcgccggag cgcgtccctg cccttagcgg ggcttgcccc agtcgcaggg gcacatccag
      181 ccgctgcggc tgacagcagc cgcgcgcgcg ggagtctgcg gggtcgcggc agccgcacct
      241 gcgcgggcga ccagcgcaag gtccccgccc ggctgggcgg gcagcaaggg ccggggagag
      301 ggtgcgggtg caggcggggg ccccacaggg ccaccttctt gcccggcggc tgccgctgga
      361 aaatgtctca ggagaggccc acgttctacc ggcaggagct gaacaagaca atctgggagg
      421 tgcccgagcg ttaccagaac ctgtctccag tgggctctgg cgcctatggc tctgtgtgtg
      481 ctgcttttga cacaaaaacg gggttacgtg tggcagtgaa gaagctctcc agaccatttc
      541 agtccatcat tcatgcgaaa agaacctaca gagaactgcg gttacttaaa catatgaaac
      601 atgaaaatgt gattggtctg ttggacgttt ttacacctgc aaggtctctg gaggaattca
      661 atgatgtgta tctggtgacc catctcatgg gggcagatct gaacaacatt gtgaaatgtc
      721 agaagcttac agatgaccat gttcagttcc ttatctacca aattctccga ggtctaaagt
      781 atatacattc agctgacata attcacaggg acctaaaacc tagtaatcta gctgtgaatg
      841 aagactgtga gctgaagatt ctggattttg gactggctcg gcacacagat gatgaaatga
      901 caggctacgt ggccactagg tggtacaggg ctcctgagat catgctgaac tggatgcatt
      961 acaaccagac agttgatatt tggtcagtgg gatgcataat ggccgagctg ttgactggaa
     1021 gaacattgtt tcctggtaca gaccatattg atcagttgaa gctcatttta agactcgttg
     1081 gaaccccagg ggctgagctt ttgaagaaaa tctcctcaga gtctgcaaga aactatattc
     1141 agtctttgac tcagatgccg aagatgaact ttgcgaatgt atttattggt gccaatcccc
     1201 tggctgtcga cttgctggag aagatgcttg tattggactc agataagaga attacagcgg
     1261 cccaagccct tgcacatgcc tactttgctc agtaccacga tcctgatgat gaaccagtgg
     1321 ccgatcctta tgatcagtcc tttgaaagca gggacctcct tatagatgag tggaaaagcc
     1381 tgacctatga tgaagtcatc agctttgtgc caccacccct tgaccaagaa gagatggagt
     1441 cctgagcacc tggtttctgt tctgttgatc ccacttcact gtgaggggaa ggccttttca
     1501 cgggaactct ccaaatatta ttcaagtgcc tcttgttgca gagatttcct ccatggtgga
     1561 agggggtgtg cgtgcgtgtg cgtgcgtgtt agtgtgtgtg catgtgtgtg tctgtctttg
     1621 tgggagggta agacaatatg aacaaactat gatcacagtg actttacagg aggttgtgga
     1681 tgctccaggg cagcctccac cttgctcttc tttctgagag ttggctcagg cagacaagag
     1741 ctgctgtcct tttaggaata tgttcaatgc aaagtaaaaa aatatgaatt gtccccaatc
     1801 ccggtcatgc ttttgccact ttggcttctc ctgtgacccc accttgacgg tggggcgtag
     1861 acttgacaac atcccacagt ggcacggaga gaaggcccat accttctggt tgcttcagac
     1921 ctgacaccgt ccctcagtga tacgtacagc caaaaaggac caactggctt ctgtgcacta
     1981 gcctgtgatt aacttgctta gtatggttct cagatcttga cagtatattt gaaactgtaa
     2041 atatgtttgt gccttaaaag gagagaagaa agtgtagata gttaaaagac tgcagctgct
     2101 gaagttctga gccgggcaag tcgagagggc tgttggacag ctgcttgtgg gcccggagta
     2161 atcaggcagc cttcataggc ggtcatgtgt gcatgtgagc acatgcgtat atgtgcgtct
     2221 ctctttctcc ctcaccccca ggtgttgcca tttctctgct tacccttcac ctttggtgca
     2281 gaggtttctt gaatatctgc cccagtagtc agaagcaggt tcttgatgtc atgtacttcc
     2341 tgtgtactct ttatttctag cagagtgagg atgtgttttg cacgtcttgc tatttgagca
     2401 tgcacagctg cttgtcctgc tctcttcagg aggccctggt gtcaggcagg tttgccagtg
     2461 aagacttctt gggtagttta gatcccatgt cacctcagct gatattatgg caagtgatat
     2521 cacctctctt cagcccctag tgctattctg tgttgaacac aattgatact tcaggtgctt
     2581 ttgatgtgaa aatcatgaaa agaggaacag gtggatgtat agcattttta ttcatgccat
     2641 ctgttttcaa ccaactattt ttgaggaatt atcatgggaa aagaccaggg cttttcccag
     2701 gaatatccca aacttcggaa acaagttatt ctcttcactc ccaataacta atgctaagaa
     2761 atgctgaaaa tcaaagtaaa aaattaaagc ccataaggcc agaaactcct tttgctgtct
     2821 ttctctaaat atgattactt taaaataaaa aagtaacaag gtgtcttttc cactcctatg
     2881 gaaaagggtc ttcttggcag cttaacattg acttcttggt ttggggagaa ataaattttg
     2941 tttcagaatt ttgtatattg taggaatccc tttgagaatg tgattccttt tgatggggag
     3001 aaagggcaaa ttattttaat attttgtatt ttcaacttta taaagataaa atatcctcag
     3061 gggtggagaa gtgtcgtttt cataacttgc tgaatttcag gcattttgtt ctacatgagg
     3121 actcatatat ttaagccttt tgtgtaataa gaaagtataa agtcacttcc agtgttggct
     3181 gtgtgacaga atcttgtatt tgggccaagg tgtttccatt tctcaatcag tgcagtgata
     3241 catgtactcc agagggacag ggtggacccc ctgagtcaac tggagcaaga aggaaggagg
     3301 cagactgatg gcgattccct ctcacccggg actctccccc tttcaaggaa agtgaacctt
     3361 taaagtaaag gcctcatctc ctttattgca gttcaaatcc tcaccatcca cagcaagatg
     3421 aattttatca gccatgtttg gttgtaaatg ctcgtgtgat ttcctacaga aatactgctc
     3481 tgaatatttt gtaataaagg tctttgcaca tgtgaccaca tacgtgttag gaggctgcat
     3541 gctctggaag cctggactct aagctggagc tcttggaaga gctcttcggt ttctgagcat
     3601 aatgctccca tctcctgatt tctctgaaca gaaaacaaaa gagagaatga gggaaattgc
     3661 tattttattt gtattcatga acttggctgt aatcagttat gccgtatagg atgtcagaca
     3721 ataccactgg ttaaaataaa gcctattttt caaattt
//

LOCUS       NM_144503               3861 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens F11 receptor (F11R), transcript variant 4, mRNA.
ACCESSION   NM_144503
VERSION     NM_144503.1  GI:21464110
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3861)
  AUTHORS   Mandell,K.J., McCall,I.C. and Parkos,C.A.
  TITLE     Involvement of the junctional adhesion molecule-1 (JAM1) homodimer
            interface in regulation of epithelial barrier function
  JOURNAL   J. Biol. Chem. 279 (16), 16254-16262 (2004)
   PUBMED   14749337
  REMARK    GeneRIF: homodimer formation may be important for localization of
            JAM1 at tight junctions and for regulation of epithelial barrier
            function
REFERENCE   2  (bases 1 to 3861)
  AUTHORS   Naik,M.U., Vuppalanchi,D. and Naik,U.P.
  TITLE     Essential role of junctional adhesion molecule-1 in basic
            fibroblast growth factor-induced endothelial cell migration
  JOURNAL   Arterioscler. Thromb. Vasc. Biol. 23 (12), 2165-2171 (2003)
   PUBMED   12958043
  REMARK    GeneRIF: JAM-1 is required for basic fibroblast growth
            factor-induced extracellular signal-related kinase activation that
            leads to endothelial cell migration on vitronectin.
REFERENCE   3  (bases 1 to 3861)
  AUTHORS   Naik,U.P. and Eckfeld,K.
  TITLE     Junctional adhesion molecule 1 (JAM-1)
  JOURNAL   J. Biol. Regul. Homeost. Agents 17 (4), 341-347 (2003)
  MEDLINE   23237501
   PUBMED   15065765
  REMARK    GeneRIF: JAM1 structure, role and tissue distribution (review)
REFERENCE   4  (bases 1 to 3861)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
  MEDLINE   22887296
   PUBMED   12975309
REFERENCE   5  (bases 1 to 3861)
  AUTHORS   Naik,M.U., Mousa,S.A., Parkos,C.A. and Naik,U.P.
  TITLE     Signaling through JAM-1 and alphavbeta3 is required for the
            angiogenic action of bFGF: dissociation of the JAM-1 and
            alphavbeta3 complex
  JOURNAL   Blood 102 (6), 2108-2114 (2003)
  MEDLINE   22840644
   PUBMED   12750158
  REMARK    GeneRIF: signaling through JAM-1 and alphavbeta3 is necessary for
            bFGF-induced angiogenesis.
REFERENCE   6  (bases 1 to 3861)
  AUTHORS   Wenzel,K., Felix,S.B., Flachmeier,C., Heere,P., Schulze,W.,
            Grunewald,I., Pankow,H., Hewelt,A., Scherneck,S., Bauer,D. and
            Hoehe,M.R.
  TITLE     Identification and characterization of KAT, a novel gene
            preferentially expressed in several human cancer cell lines
  JOURNAL   Biol. Chem. 384 (5), 763-775 (2003)
  MEDLINE   22701983
   PUBMED   12817473
REFERENCE   7  (bases 1 to 3861)
  AUTHORS   Babinska,A., Kedees,M.H., Athar,H., Ahmed,T., Batuman,O.,
            Ehrlich,Y.H., Hussain,M.M. and Kornecki,E.
  TITLE     F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial
            cells: role in inflammatory thrombosis
  JOURNAL   Thromb. Haemost. 88 (5), 843-850 (2002)
  MEDLINE   22315648
   PUBMED   12428104
  REMARK    GeneRIF: platelets adhere specifically to F11R of cytokine-
            (TNF-alpha, INF-gamma) stimulated vascular endothelial cells
REFERENCE   8  (bases 1 to 3861)
  AUTHORS   Jacquot,C., Lanco,X., Carbonnelle,D., Sevestre,O., Tomasoni,C.,
            Briad,G., Juget,M., Roussis,V. and Roussakis,C.
  TITLE     Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation
            arrest in a non-small cell bronchopulmonary cancer line
  JOURNAL   Anticancer Res. 22 (4), 2229-2235 (2002)
  MEDLINE   22164488
   PUBMED   12174908
  REMARK    GeneRIF: Effect of gene on proliferation arrest in a non-small cell
            bronchopulmonary cancer line.
REFERENCE   9  (bases 1 to 3861)
  AUTHORS   Babinska,A., Kedees,M.H., Athar,H., Sobocki,T., Sobocka,M.B.,
            Ahmed,T., Ehrlich,Y.H., Hussain,M.M. and Kornecki,E.
  TITLE     Two regions of the human platelet F11-receptor (F11R) are critical
            for platelet aggregation, potentiation and adhesion
  JOURNAL   Thromb. Haemost. 87 (4), 712-721 (2002)
  MEDLINE   22002615
   PUBMED   12008956
  REMARK    GeneRIF: Two domains in the N-terminus and 1st Ig-fold of F11R were
            found, through which M.Ab.F11 triggers platelet aggregation. These
            2 regions form an active site within the conformation of this cell
            adhesion molecule.
REFERENCE   10 (bases 1 to 3861)
  AUTHORS   Ostermann,G., Weber,K.S., Zernecke,A., Schr and Weber,C.
  TITLE     JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in
            transendothelial migration of leukocytes
  JOURNAL   Nat. Immunol. 3 (2), 151-158 (2002)
  MEDLINE   21671732
   PUBMED   11812992
REFERENCE   11 (bases 1 to 3861)
  AUTHORS   Barton,E.S., Forrest,J.C., Connolly,J.L., Chappell,J.D., Liu,Y.,
            Schnell,F.J., Nusrat,A., Parkos,C.A. and Dermody,T.S.
  TITLE     Junction adhesion molecule is a receptor for reovirus
  JOURNAL   Cell 104 (3), 441-451 (2001)
  MEDLINE   21135266
   PUBMED   11239401
REFERENCE   12 (bases 1 to 3861)
  AUTHORS   Naik,U.P., Naik,M.U., Eckfeld,K., Martin-DeLeon,P. and Spychala,J.
  TITLE     Characterization and chromosomal localization of JAM-1, a platelet
            receptor for a stimulatory monoclonal antibody
  JOURNAL   J. Cell. Sci. 114 (Pt 3), 539-547 (2001)
  MEDLINE   21102128
   PUBMED   11171323
REFERENCE   13 (bases 1 to 3861)
  AUTHORS   Gupta,S.K., Pillarisetti,K. and Ohlstein,E.H.
  TITLE     Platelet agonist F11 receptor is a member of the immunoglobulin
            superfamily and identical with junctional adhesion molecule (JAM):
            regulation of expression in human endothelial cells and macrophages
  JOURNAL   IUBMB Life 50 (1), 51-56 (2000)
  MEDLINE   20537956
   PUBMED   11087121
REFERENCE   14 (bases 1 to 3861)
  AUTHORS   Liu,Y., Nusrat,A., Schnell,F.J., Reaves,T.A., Walsh,S., Pochet,M.
            and Parkos,C.A.
  TITLE     Human junction adhesion molecule regulates tight junction resealing
            in epithelia
  JOURNAL   J. Cell. Sci. 113 (Pt 13), 2363-2374 (2000)
  MEDLINE   20312834
   PUBMED   10852816
REFERENCE   15 (bases 1 to 3861)
  AUTHORS   Sobocka,M.B., Sobocki,T., Banerjee,P., Weiss,C., Rushbrook,J.I.,
            Norin,A.J., Hartwig,J., Salifu,M.O., Markell,M.S., Babinska,A.,
            Ehrlich,Y.H. and Kornecki,E.
  TITLE     Cloning of the human platelet F11 receptor: a cell adhesion
            molecule member of the immunoglobulin superfamily involved in
            platelet aggregation
  JOURNAL   Blood 95 (8), 2600-2609 (2000)
  MEDLINE   20218744
   PUBMED   10753840
  REMARK    GeneRIF: The F11 receptor (F11R) was discovered in 1990 (Kornecki
            et al.), partially sequenced (1995) and cloned (Sobocka, et al) by
            this group. A 100% homology exists between platelet F11R and JAM.
REFERENCE   16 (bases 1 to 3861)
  AUTHORS   Ozaki,H., Ishii,K., Horiuchi,H., Arai,H., Kawamoto,T., Okawa,K.,
            Iwamatsu,A. and Kita,T.
  TITLE     Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes
            redistribution of junctional adhesion molecule in human endothelial
            cells
  JOURNAL   J. Immunol. 163 (2), 553-557 (1999)
  MEDLINE   99323940
   PUBMED   10395639
REFERENCE   17 (bases 1 to 3861)
  AUTHORS   Naik,U.P., Ehrlich,Y.H. and Kornecki,E.
  TITLE     Mechanisms of platelet activation by a stimulatory antibody:
            cross-linking of a novel platelet receptor for monoclonal antibody
            F11 with the Fc gamma RII receptor
  JOURNAL   Biochem. J. 310 (Pt 1), 155-162 (1995)
  MEDLINE   95374438
   PUBMED   7646439
REFERENCE   18 (bases 1 to 3861)
  AUTHORS   Kornecki,E., Walkowiak,B., Naik,U.P. and Ehrlich,Y.H.
  TITLE     Activation of human platelets by a stimulatory monoclonal antibody
  JOURNAL   J. Biol. Chem. 265 (17), 10042-10048 (1990)
  MEDLINE   90277613
   PUBMED   2351647
  REMARK    GeneRIF: F11 receptor (F11R) was discovered by Kornecki, 1990 (JBC,
            265:10042) on platelets.  A 100% homology exists between the
            platelet F11R and human JAM at the protein level.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF111713.1 and AF172398.2.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. The protein encoded by this immunoglobulin
            superfamily gene member is an important regulator of tight junction
            assembly in epithelia. In addition, the encoded protein can act as
            (1) a receptor for reovirus, (2) a ligand for the integrin LFA1,
            involved in leukocyte transmigration, and (3) a platelet receptor.
            Five transcript variants encoding two different isoforms have been
            found for this gene.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 4 encode isoform a.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2-q21.3"
     gene            1..3861
                     /gene="F11R"
                     /note="synonyms: JAM, KAT, JAM1, JCAM, JAM-1, PAM-1"
                     /db_xref="GeneID:50848"
                     /db_xref="MIM:605721"
     CDS             283..1182
                     /gene="F11R"
                     /note="isoform a precursor is encoded by transcript
                     variant 4; junctional adhesion molecule 1; platelet F11
                     receptor; platelet adhesion molecule; KAT protein;
                     go_component: tight junction [goid 0005923] [evidence
                     IEA];
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_process: cell motility [goid 0006928] [evidence NR];
                     go_process: inflammatory response [goid 0006954] [evidence
                     TAS] [pmid 10395639]"
                     /codon_start=1
                     /product="F11 receptor isoform a precursor"
                     /protein_id="NP_653086.1"
                     /db_xref="GI:21464111"
                     /db_xref="GeneID:50848"
                     /db_xref="MIM:605721"
                     /translation="MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENN
                     PVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRE
                     DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP
                     PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY
                     GTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSK
                     KVIYSQPSARSEGEFKQTSSFLV"
     sig_peptide     283..357
                     /gene="F11R"
     mat_peptide     358..1179
                     /gene="F11R"
                     /product="F11 receptor isoform a"
     polyA_signal    3838..3843
                     /gene="F11R"
     polyA_site      3861
                     /gene="F11R"
                     /evidence=experimental
ORIGIN      
        1 gccgagaggg cgggccaggg ccgcactccg gagactcgcg gttgctacgc gcaccatggc
       61 tggagacgga gtttcgctct tgatgcccag caggctagag tgcgatggcg cgatttcggc
      121 tcactgcaac ctcctcctcc cagaggtact tctcagccct ctagctccaa ctgagaaccc
      181 agccagtcag gaagtcgcta cttcgggaac accaaccaat cagggggccg tcacctgctg
      241 aaggagtcct tcggcggctg ttgtgtcggg agcctgatcg cgatggggac aaaggcgcaa
      301 gtcgagagga aactgttgtg cctcttcata ttggcgatcc tgttgtgctc cctggcattg
      361 ggcagtgtta cagtgcactc ttctgaacct gaagtcagaa ttcctgagaa taatcctgtg
      421 aagttgtcct gtgcctactc gggcttttct tctccccgtg tggagtggaa gtttgaccaa
      481 ggagacacca ccagactcgt ttgctataat aacaagatca cagcttccta tgaggaccgg
      541 gtgaccttct tgccaactgg tatcaccttc aagtccgtga cacgggaaga cactgggaca
      601 tacacttgta tggtctctga ggaaggcggc aacagctatg gggaggtcaa ggtcaagctc
      661 atcgtgcttg tgcctccatc caagcctaca gttaacatcc cctcctctgc caccattggg
      721 aaccgggcag tgctgacatg ctcagaacaa gatggttccc caccttctga atacacctgg
      781 ttcaaagatg ggatagtgat gcctacgaat cccaaaagca cccgtgcctt cagcaactct
      841 tcctatgtcc tgaatcccac aacaggagag ctggtctttg atcccctgtc agcctctgat
      901 actggagaat acagctgtga ggcacggaat gggtatggga cacccatgac ttcaaatgct
      961 gtgcgcatgg aagctgtgga gcggaatgtg ggggtcatcg tggcagccgt ccttgtaacc
     1021 ctgattctcc tgggaatctt ggtttttggc atctggtttg cctatagccg aggccacttt
     1081 gacagaacaa agaaagggac ttcgagtaag aaggtgattt acagccagcc tagtgcccga
     1141 agtgaaggag aattcaaaca gacctcgtca ttcctggtgt gagcctggtc ggctcaccgc
     1201 ctatcatctg catttgcctt actcaggtgc taccggactc tggcccctga tgtctgtagt
     1261 ttcacaggat gccttatttg tcttctacac cccacagggc cccctacttc ttcggatgtg
     1321 tttttaataa tgtcagctat gtgccccatc ctccttcatg ccctccctcc ctttcctacc
     1381 actgctgagt ggcctggaac ttgtttaaag tgtttattcc ccatttcttt gagggatcag
     1441 gaaggaatcc tgggtatgcc attgacttcc cttctaagta gacagcaaaa atggcggggg
     1501 tcgcaggaat ctgcactcaa ctgcccacct ggctggcagg gatctttgaa taggtatctt
     1561 gagcttggtt ctgggctctt tccttgtgta ctgacgacca gggccagctg ttctagagcg
     1621 ggaattagag gctagagcgg ctgaaatggt tgtttggtga tgacactggg gtccttccat
     1681 ctctggggcc cactctcttc tgtcttccca tgggaagtgc cactgggatc cctctgccct
     1741 gtcctcctga atacaagctg actgacattg actgtgtctg tggaaaatgg gagctcttgt
     1801 tgtggagagc atagtaaatt ttcagagaac ttgaagccaa aaggatttaa aaccgctgct
     1861 ctaaagaaaa gaaaactgga ggctgggcgc agtggctcac gcctataatc ccagaggctg
     1921 aggcaggcgg atcacctgag gtcaggagtt caagatcagc ctgaccaaca tggagaaacc
     1981 ctactaaaaa tacaaagtta gccaggcata gtggtgcatg cctgtaatcc cagctgctca
     2041 ggagcctggc aacaagagca aaactccagc tcaaaaaaaa aaagaaagaa aagaaaaagc
     2101 tggagctggt ggcttaggcc atcacccttc ccttggctgg aactactgga cagacccttt
     2161 tgagatgtgc ctgtggtgct gtggagatgt gtgtagtggt cttagctctt tgttgagctt
     2221 gtgtgtgtgt tgtgtagtct tagctgtatg ctgaaattgg gcgtgtgttg gagggcttct
     2281 tagctctttg gtgagattgt atttctatgt gtttgtatca gctgaatgtt gctggaaata
     2341 aaaccttggt ttgtcaaggc tcttttttgt gggaagtaag taggggaaaa ggtctttgag
     2401 ggttcctagg ctcctttgta caacaggaaa atgcctcaaa gccttgcttc ccagcaacct
     2461 ggggctggtt cccagtgcct ggtcctgccc cttcctggtt cttatctcaa ggcagagctt
     2521 ctgaatttca ggccttcatt ccagagccct cttgtggcca ggccttcctt tgctggagga
     2581 aggtacacag ggtgaagctg atgctgtact tgggggatct ccttggcctg ttccaccaag
     2641 tgagagaagg tacttactct tgtacctcct gttcagccag gtgcattaac agacctccct
     2701 acagctgtag gaactactgt cccagagctg aggcaagggg atttctcagg tcatttggag
     2761 aacaagtgct ttagtagtag tttaaagtag taactgctac tgtatttagt ggggtggaat
     2821 tcagaagaaa tttgaagacc agatcatggg tggtctgcat gtgaatgaac aggaatgagc
     2881 cggacagcct ggctgtcatt gctttcttcc tccccatttg gacccttctc tgcccttaca
     2941 tttttgtttc tccatctacc accatccacc agtctattta ttaacttagc aagaggacaa
     3001 gtaaagggcc ctcttggctt gattttgctt ctttctttct gtggaggata tactaagtgc
     3061 gactttgccc tatcctattt ggaaatccct aacagaattg agttttctat taaggatcca
     3121 aaaagaaaaa caaaatgcta atgaagccat cagtcaaggg tcacatgcca ataaacaata
     3181 aattttccag aagaaatgaa atccaactag acaaataaag tagagcttat gaaatggttc
     3241 agtaaagatg agtttgttgt tttttgtttt gttttgtttt gtttttttaa agacggagtc
     3301 tcgctctgtc acccaggctg gagtgcagtg gtatgatctt ggctcactgt aacctccgcc
     3361 tcccgggttc aagccattct cctgcctcag tctcctgagt agctgggatt acgggtgcgt
     3421 gccaccatgc ctggctaatt tttgtgtttt tagtagagac agggtttcac catgttggtc
     3481 gggctggtct caaactcctg acctcttgat ccgcctgcct tggcctccca aagtgatggg
     3541 attacagatg tgagccaccg tgcctagcca aggatgagat ttttaaagta tgtttcagtt
     3601 ctgtgtcatg gttggaagac agagtaggaa ggatatggaa aaggtcatgg ggaagcagag
     3661 gtgattcatg gctctgtgaa tttgaggtga atggttcctt attgtctagg ccacttgtga
     3721 agaatatgag tcagttattg ccagccttgg aatttacttc tctagcttac aatggacctt
     3781 ttgaactgga aaacaccttg tctgcattca ctttaaaatg tcaaaactaa tttttataat
     3841 aaatgtttat tttcacattg a
//

LOCUS       NM_144578               2861 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens chromosome 14 open reading frame 32 (C14orf32), mRNA.
ACCESSION   NM_144578
VERSION     NM_144578.2  GI:34147697
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Lefebvre,C., Terret,M.E., Djiane,A., Rassinier,P., Maro,B. and
            Verlhac,M.H.
  TITLE     Meiotic spindle stability depends on MAPK-interacting and
            spindle-stabilizing protein (MISS), a new MAPK substrate
  JOURNAL   J. Cell Biol. 157 (4), 603-613 (2002)
   PUBMED   12011110
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC015621.2.
            On Aug 25, 2003 this sequence version replaced gi:21389356.
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2-q22.3"
     gene            1..2861
                     /gene="C14orf32"
                     /note="synonyms: MISS, MGC23138, c14_5346"
                     /db_xref="GeneID:93487"
     CDS             126..863
                     /gene="C14orf32"
                     /codon_start=1
                     /product="MAPK-interacting and spindle-stabilizing
                     protein"
                     /protein_id="NP_653179.1"
                     /db_xref="GI:21389357"
                     /db_xref="GeneID:93487"
                     /translation="MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSNPWNNPS
                     APSSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPY
                     PAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQ
                     YPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLY
                     PTPSNPFQVPSGPSGAPPMPGGPHSYH"
ORIGIN      
        1 ctggtgctgt tgccgccgct gctctagctg ccgtcagtca ggctgcgccc gcgtcttcag
       61 ggcccagtcc ctcggaccca tcgccgcttc tagaccctac tgcggtctcg gatattgccg
      121 ggaaaatgtc tgatgaattt tcgttggcag atgcactacc tgaacactcc cctgccaaaa
      181 cctctgctgt gagcaataca aaacctggcc aacctcctca aggctggcca ggctccaacc
      241 cttggaataa tccgagtgct ccatcttcag tgccatctgg actcccacca agtgcaacac
      301 cctccactgt gccttttgga ccagcaccaa caggaatgta tccctccgtg cctcccaccg
      361 gaccacctcc aggaccccca gcaccctttc ctccttccgg accatcatgt cccccacctg
      421 gtggtcctta tccagcccca actgtgccgg gccctggccc cacagggcca tatcctacac
      481 caaatatgcc ctttccagag ctacccagac catatggtgc acccacagat ccagctgcag
      541 ctggtccttt aggtccatgg ggatccatgt cttctggacc ttgggcgcca ggaatgggag
      601 ggcagtatcc tacccctaat atgccatatc catctccagg cccatatccc gctcctcctc
      661 ctccccaggc ccctggggca gcaccacctg ttccatgggg caccgttcca ccaggagcct
      721 ggggaccacc agcaccatat cctgccccta caggatcgta tcccacacca ggactctatc
      781 ctactcccag taatcctttc caagtgcctt caggaccttc tggtgctcca ccaatgcctg
      841 gtggccccca ttcttaccat taagttaaca atggacgaag agatgacgct ttgctttttg
      901 aagtacatgt atatgcacat gaatgcatat ataaaaattg ctggtttcac tattagaggg
      961 cattcatgaa agaacaactc ttgcacctct cagagaagat aactgcctct tgtacttgga
     1021 tgcgtagtac atcatatgta taccatcaga taaaagcata gaagtaaatc attcggatgt
     1081 gatttttatt tggttttcat ggaaagttaa agtgataaag tatattgaat agttctttga
     1141 cagaatttgt ttaaactatg aaactacaca cttaaaaatc taagatgtgg attattgtta
     1201 gaatctgcaa cttcattggc aaattatttc aagtattttt ctataatcac tttccccttc
     1261 taaataaata aacttcgaga ataacccatc ataatccaaa caaatgatgc ctcaacattt
     1321 tgagctgctc tgtcggacaa ataaacctgg tcctcttgag gttatatttt ggatatacat
     1381 ttttaaactg tcagtaatta ttgtcagatg tggagttcaa tagccagcca gtgttcattt
     1441 ttatccttga gcttttagta aaaacttcct ggttttattt ttagtcattg ggtcatacag
     1501 cactaaagtc tgctatttat ggaaactaac ttttttgttt ttaatccagg ccaacatgta
     1561 tgtaaattaa atttttagat aattgattat ctctttgtac tacttgagat ttgattatga
     1621 gatgtgcata ttgctttggg aagagctcga ggaaggaaat aattctctcc tttgttttga
     1681 acctcaaact agataaaccc taggaattgc ttaactgcaa caagtaattt tcattcccac
     1741 aaaaacctga ggcagctctt ttgcccagag cgttccctgt agccaccccc accccacttg
     1801 cccttggttc tttagaagga gcacacacat cccttgattc ctccctgatg tggtaaactg
     1861 gcacactcca ggggtctaaa acataaaaca gttgtgttta gggaacctta agtcatgcag
     1921 acatgactgt tctctttgta caagtgtgaa tcaaaatatg tatctctttt tcagagtctg
     1981 gttaagctat gtcattgtct actgcatagt ttcctgagtc tgtttgtaaa gtgcttatgg
     2041 ctaacagttc agttctgtat ttgttgacag gtaaataagt ggagttgagt gccatctttg
     2101 aaaaaattac cctctagctc taacactgaa aataataata aattgtagat ctctgcaact
     2161 aagtttaaag cagtgtgact gtgttgctta aatatcaagt attgtttata accaccaaaa
     2221 aaaaaagccc tggtagtttt ttggcacctt atgtttaaat cagattctta gatttggagt
     2281 agacctgacc ttgttattta ttagataaca ttttgaatgt atccattgga tttctaaaat
     2341 gtattgtgaa tttctcagac aaacaggatt tatgctggag ctctgttttg cttagaaata
     2401 aaatatttag tagtttattt ctgctctaat taaaatgtca ctttacccct ggataaaggc
     2461 actttcactg cctgtcactg atcagcagat actgacttgt tgccattaag tgaacttgac
     2521 ttcttatgtg tgctctatga gtttgttgta attttcttct tgaaattgtg atttttcact
     2581 gacagtaatg acaaatttaa tgtatgtaat tgtctatgca ttttaagtta aactgcctaa
     2641 aatgtgattt gagacatata catatgtttg tattataaat tgtaagcaat cagtttgaga
     2701 tactaggttt tatcacctgc tgctgtattt gtaaacaaag acaaatgttg ctttaagaag
     2761 taattataat taggaatagg ctatggatgt gatacttggt attttttaag ataaacttgt
     2821 ttgcttttgt gtattaaaaa aaaaaaaaaa aaaaaaaaaa a
//

LOCUS       NM_145648               2807 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens solute carrier family 15, member 4 (SLC15A4), mRNA.
ACCESSION   NM_145648
VERSION     NM_145648.1  GI:21717815
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Botka,C.W., Wittig,T.W., Graul,R.C., Nielsen,C.U., Higaka,K.,
            Amidon,G.L. and Sadee,W.
  TITLE     Human proton/oligopeptide transporter (POT) genes: identification
            of putative human genes using bioinformatics
  JOURNAL   AAPS PharmSci 2 (2), E16 (2000)
   PUBMED   11741232
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY038999.1.
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.32"
     gene            1..2807
                     /gene="SLC15A4"
                     /note="synonyms: PHT1, PTR4"
                     /db_xref="GeneID:121260"
     CDS             59..1792
                     /gene="SLC15A4"
                     /note="peptide-histidine transporter 4;
                     go_component: integral to membrane [goid 0016021]
                     [evidence IEA];
                     go_function: transporter activity [goid 0005215] [evidence
                     IEA];
                     go_process: transport [goid 0006810] [evidence IEA];
                     go_process: oligopeptide transport [goid 0006857]
                     [evidence IEA]"
                     /codon_start=1
                     /product="solute carrier family 15, member 4"
                     /protein_id="NP_663623.1"
                     /db_xref="GI:21717816"
                     /db_xref="GeneID:121260"
                     /translation="MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTE
                     LLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGR
                     ARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAG
                     LVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQ
                     NVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGE
                     RQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTV
                     YFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPIL
                     RRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLS
                     LWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLA
                     LVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRS
                     RANGVPTSRRA"
ORIGIN      
        1 caggttgggt tctgggacag gtgacccggc ggcggggcga ggcagctggc ggcgtcgcat
       61 ggagggctct gggggcggtg cgggcgagcg ggcgccgctg ctgggcgcgc ggcgggcggc
      121 ggcggccgcg gcggcggctg gggcgttcgc gggccggcgc gcggcgtgcg gggccgtgct
      181 gctgacggag ctgctggagc gcgccgcttt ctacggcatc acgtccaacc tggtgctatt
      241 cctgaacggg gcgccgttct gctgggaggg cgcgcaggcc agcgaggcgc tgctgctctt
      301 catgggcctc acctacctgg gctcgccgtt cggaggctgg ctggccgacg cgcggctggg
      361 ccgggcgcgc gccatcctgc tgagcctggc gctctacctg ctgggcatgc tggccttccc
      421 gctgctggcc gcgcccgcca cgcgagccgc gctctgcggt tccgcgcgcc tgctcaactg
      481 cacggcgcct ggtcccgacg ccgccgcccg ctgctgctca ccggccacct tcgcggggct
      541 ggtgctggtg ggcctgggcg tggccaccgt caaggccaac atcacgccct tcggcgccga
      601 ccaggttaaa gatcgaggtc cggaagccac taggagattt tttaattggt tttattggag
      661 cattaacctg ggagcgatcc tgtcgttagg tggcattgcc tatattcagc agaacgtcag
      721 ctttgtcact ggttatgcga tccccactgt ctgcgtcggc cttgcttttg tggtcttcct
      781 ctgtggccag agcgttttca tcaccaagcc tcctgatggc agtgccttca ccgacatgtt
      841 caagatactg acgtattcct gctgttccca gaagcgaagt ggagagcgcc agagtaatgg
      901 tgaaggcatt ggagtctttc agcaatcttc taaacaaagt ctgtttgatt catgtaagat
      961 gtctcatggt gggccattta cagaagagaa agtggaagat gtgaaagctc tggtcaagat
     1021 tgtccctgtt ttcttggctt tgatacctta ctggacagtg tatttccaaa tgcagacaac
     1081 atatgtttta cagagtcttc atttgaggat tccagaaatt tcaaatatta caaccactcc
     1141 tcacacgctc cctgcagcct ggctgaccat gtttgatgct gtgctcatcc tcctgctcat
     1201 ccctctgaag gacaaactgg tcgatcccat tttgagaaga catggcctgc tcccatcctc
     1261 cctgaagagg atcgccgtgg gcatgttctt tgtcatgtgc tcggcctttg ctgcaggaat
     1321 tttggagagt aaaaggctga accttgttaa agagaaaacc attaatcaga ccatcggcaa
     1381 cgtcgtctac catgctgccg atctgtcgct gtggtggcag gtgccgcagt acttgctgat
     1441 tgggatcagc gagatctttg caagtatcgc aggcctggaa tttgcatact cagctgcccc
     1501 caagtccatg cagagtgcca taatgggctt gttctttttc ttctctggcg tcgggtcgtt
     1561 cgtgggttct ggactgctgg cactggtgtc tatcaaagcc atcggatgga tgagcagtca
     1621 cacagacttt ggtaatatta acggctgcta tttgaactat tacttttttc ttctggctgc
     1681 tattcaagga gctaccctcc tgcttttcct cattatttct gtgaaatatg accatcatcg
     1741 agaccatcag cgatcaagag ccaatggcgt gcccaccagc aggagggcct gaccttcctg
     1801 aggccatgtg cggtttctga ggctgacatg tcagtaactg actggggtgc actgagaaca
     1861 ggcaagactt taaattccca taaaatgtct gacttcactg aaacttgcat gttgcctgga
     1921 ttgatttctt ctttccctct atccaaagga gcttggtaag tgccttactg cagcgtgtct
     1981 cctggcacgc tgggccctcc gggaggagag ctgcagattt cgagtatgtc gcttgtcatt
     2041 caaggtctct gtgaatcctc tagctgggtt ccctttttta cagaaactca caaatggaga
     2101 ttgcaaagtc ttggggaact ccacgtgtta gttggcatcc cagtttctta aacaaatagt
     2161 atcacctgct tcccatagcc atatctcact gtaaaaaaaa aaaattaata aactgttact
     2221 tatatttaag aaagtgagga tttttttttt ttaaagataa aagcatggtc agatgctgca
     2281 aggattttac ataaatgcca tatttatggt ttccttcctg agaacagtct tgctcttgcc
     2341 atgttctttg atttaggctg gtagtaaaca catttcatct gctgcttcaa aaagtactta
     2401 ctttttaaac catcaacatt acttttcttt cttaaggcaa ggcatgcata agagtcattt
     2461 gagaccatgt gtcccatctc aagccacaga gcaactcaca gggtacttca caccttacct
     2521 agtcagagtg cttatatata gctttatttt ggtacgattg agactaaaga ctgatcatgg
     2581 ttgtatgtaa ggaaaacatt cttttgaaca gaaatagtgt aattaaaaat aattgaaagt
     2641 gttaaatgtg aacttgagct gtttgaccag ccacattttt gtattgttac tgtacgtgta
     2701 tctggggctt ctccgtttgt taatactttt tctgtatttg ttgctgtatt tttggcataa
     2761 ctttattata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//

LOCUS       NM_152261               3167 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens hypothetical protein MGC17943 (MGC17943), mRNA.
ACCESSION   NM_152261
VERSION     NM_152261.1  GI:22748614
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC020522.1.
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..3167
                     /gene="MGC17943"
                     /db_xref="GeneID:90488"
     CDS             214..564
                     /gene="MGC17943"
                     /codon_start=1
                     /product="hypothetical protein MGC17943"
                     /protein_id="NP_689474.1"
                     /db_xref="GI:22748615"
                     /db_xref="GeneID:90488"
                     /translation="MNQTDKNQQEIPSYLNDEPPEGSMKDHPQQQPGMLSRVTGGIFS
                     VTKGAVGATIGGVAWIGGKSLEVTKTAVTTVPSMGIGLVKGGVSAVAGGVTAVGSAVV
                     NKVPLTGKKKDKSD"
ORIGIN      
        1 cctgagagga cgcctctgga gccgcgactg cccggggttg tgccggccgc cgctgccgcc
       61 caggccgcct cagctctcct ctgcgccggc ccgctcactc cgcccggccc cagccctagc
      121 gctggccgcg accccggcgc ctttgaaact tctgctggtg tgagtgccct caggggttcc
      181 ccaggaatat cgatacaaca ccaacaggag atcatgaatc agacagataa aaatcaacaa
      241 gaaatcccat cataccttaa tgatgaacca ccagaaggtt caatgaaaga tcacccacag
      301 cagcagccag gcatgttgtc ccgtgtgact gggggtatct tcagtgttac aaagggagct
      361 gttggtgcca ccattggtgg tgtggcttgg attggtggaa agagtctgga agtgaccaaa
      421 acagctgtta caactgtgcc ttccatggga atagggctgg tgaaaggggg tgtctctgct
      481 gtggctggag gtgttacagc tgttgggtct gctgttgtaa acaaagtgcc cttaacagga
      541 aagaagaaag acaaatctga ctgaaatata gagatacact tgcgctccac agcactgtaa
      601 tgccagtggc attgaattgc taaattatgg actacaacca agtcaactgt tttggacgtt
      661 tatcttctaa actgctgtgt tgaaagtatt gatgactggc tttcatctaa aaagaagaga
      721 ccaatacgag cacagtatat gaaggtttct catacttaag ttccaggttt ttatctggta
      781 aaatgttaca cttactcggt tgtaactgaa gatatggtat gtttgaatat ttactataag
      841 tctttcagtt tgactaaaaa tgtgaaagtt gaatttagta gatgatcttc acagttccat
      901 atgtataatg tgccaggtaa ctcacctgcc ccttaagaag ggaaccttga attacataag
      961 ccgtaccttt gatgtgccta atagtttcag atgtcttagt tttttataac catagttgat
     1021 taggccaaga ggcattcatt tcttatttaa gctggcaaaa ttagcaggaa ttagagaagt
     1081 ttaaaaagat aaatggtttt atgataatgt taaccatctt ttgttagtaa atatgcgttc
     1141 tattatttta atcattgatg ccttacaaaa gaaaacatct tttctaatac cctgaatatg
     1201 tgctgttctt agaatcatct atggattctt ttaaaggttg tttgtgaaat tagttttccc
     1261 tttttagaat ctcaggagta gtggggtaaa gacatttcct gctgtcagtg gataagacag
     1321 agcttgttaa ctgttttggc agtagttaaa atcaaattgt acacttctca gcctgggttc
     1381 atgcttcatc attaatacac ctcacagtgc ctaaggaaca tttacttact ggtcagaagg
     1441 tattttggaa gagtttcata ttaaggagga acaaataata attttaagtt cttaaaaatt
     1501 acctaaaaca ccccaaatat aaaaagaagc cttcacacct attctgtctt taggatgtct
     1561 taaattatta gcagtactcc ttttttaaaa acactgtaaa agtaaccaca aatatgtgag
     1621 gacttactat tttaaatgga atggaatgag ctccatagat tagttttgaa tataaagtat
     1681 ataaaagtgc atcagtggtt tatataggct ttaaaaacat gttatcttac agtcctttaa
     1741 agcagccata gagtttgtat catttttcaa gccaatttca gtcagggatt tgaattgttt
     1801 gattatggat gataaatgtg tcatatctta ttaatatgtc tcatgtctcg ttccttctta
     1861 atatgattta gctggaattc attttctttt cgtttcatgt ttaatttcat aaaacgttta
     1921 acaattggca tatatacttg gcattcctgt ccaccaagga ttgtaatcca agcctgggaa
     1981 aatcttaaat ttctttttac ttaaatctgg aaatttgtct ccattctgcc accttttttt
     2041 tttttttttt atagtggagg ggaggaaagg ggggtgatac cttgcagtaa gtaagtcgaa
     2101 atagcatgcc tgaaaatttg aaacagacca ttctaacacc caaggcttgt ttataaaata
     2161 cttgagaatt acattaatgt ggaatcaaca gatgcagaag aatataacat aacttttaaa
     2221 agctttcata aataccagca gcaattgtaa gcaaatctac aaaggttctt gaacctttct
     2281 attatataca aaactgaaaa gtcattaagg agttcaacta atcaggaatt aaatggtcat
     2341 ttatttcatg cagtatgatt taaggtattt cttgagattc tggtcaaatg tcataatcag
     2401 caaacgggat taaaaaaaaa actccaaaat cactaaataa ttatctaaat aatggtattg
     2461 gagaacttgt ttcctgctat ttggaagaga ttgttgcttc attgctagtt tgtatttcta
     2521 acttctacag ttatagactc cactgtgctt tgtgtctgaa tttctcagta tagacatttt
     2581 gtttactgta tgcttgcata tttattttca actttgtttg tctttaaaat tgcttgagga
     2641 aaaatggttg taattaattt ctgctacaga aaagccacct ggtacgtttt gtctcatcag
     2701 gattgtttta aattctaaac tataagtttg ttcagagggg cttttgcaat gatagcagaa
     2761 aactgtacaa atgtacagtt agttatagag gttcttgttg aaatgaactt accatctgat
     2821 gatatgtatg tacagctgtg tacttgagtc ttttttagtt tacttagaaa gactagcagt
     2881 ttgacctgtt aaacaggact agttcaagtc aagaaactaa ggttgttgta tacacctgga
     2941 ggcatctgtt attcagctta tcctttgagt gggtatttgg cacaatgagg ataaacttat
     3001 gtgacccact tgaatggctg atctaataat gttgacatta tgcattctgt acttagtgaa
     3061 atgtcagatg aaaataactg atgaataatt tttttgtatt aaagggatgg gaaaagaaca
     3121 catgaatttg ttaataaagc actatgatct gcaaaaaaaa aaaaaaa
//

LOCUS       NM_152792               2168 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens hypothetical protein FLJ25084 (FLJ25084), mRNA.
ACCESSION   NM_152792
VERSION     NM_152792.1  GI:22758145
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK055994.1.
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2168
                     /gene="FLJ25084"
                     /db_xref="GeneID:151516"
     CDS             574..1605
                     /gene="FLJ25084"
                     /note="go_function: magnesium ion binding [goid 0000287]
                     [evidence IEA];
                     go_function: aspartic-type endopeptidase activity [goid
                     0004190] [evidence IEA];
                     go_function: holo-[acyl-carrier protein] synthase activity
                     [goid 0008897] [evidence IEA];
                     go_process: fatty acid biosynthesis [goid 0006633]
                     [evidence IEA];
                     go_process: proteolysis and peptidolysis [goid 0006508]
                     [evidence IEA]"
                     /codon_start=1
                     /product="hypothetical protein FLJ25084"
                     /protein_id="NP_690005.1"
                     /db_xref="GI:22758146"
                     /db_xref="GeneID:151516"
                     /translation="MGSPGASLGIKKALQSEQATALPASAPAVSQPTAPAPSCLPKAG
                     QVIPALLREAPFSSVIAPTLLCGFLFLAWVAAEVPEESSRMAGSGARSEEGRRQHAFV
                     PEPFDGANVVPNLWLHSFEVINDLNHWDHITKLRFLKESLRGEALGVYNRLSPQDQGD
                     YGTVKEALLKAFGVPGAAPSHLPKEIVFANSMGKGYYLKGKIGKVPVRFLVDSGAQVS
                     VVHPNLWEEVTDGDLDTLQPFENVVKVANGAEMKILGVWDTAVSLGKLKLKAQFLVAN
                     ASAEEAIIGTDVLQDHNAILDFEHRTCTLKGKKFRLLPVGGSLEDEFDLELIEEDPSS
                     EEGRQELSH"
ORIGIN      
        1 gcagcagttg agtccatgta agatgattgt gcacgtgtgt gtgtgtgtgt gtgtgtgtgt
       61 gtcctcactc acttaaaaaa gaccatttct gtgcattctt tatgctggaa ccctcctctg
      121 cctccctctc caggaaatcc cataggatcc catacctgct ttagaatgtg tgtgagacac
      181 ttcccagtgc ctggcatgtg gtaggagctc agtacatgta aactgttttc ctttgaccac
      241 tcaaagtagt cacttgttgg ggaggccaat ggcggcttcc ccggtctctg agctgatggg
      301 cgtctggtcc ctgcctcccc ttccttcact ggctgatgac aaatacctga atgtcatcac
      361 atcctccgtg tcctcatctg ttattctgga acacaggcca gggagggtac agggtagtcc
      421 cccttcaaca gaggctggcc tttcttggga tgtgggctgg ctggtgttgg tccaaggatg
      481 gatgcagagg gtgaggcacc catcctgcta gtccggccgg atgctggcag gagggcgggg
      541 tgaggagggg cggagcttcc agaacaaagg agaatgggga gcccaggggc cagcctaggc
      601 atcaaaaagg ctctgcagag tgaacaggcc acagcactgc ctgcctctgc cccagcagtc
      661 agccagccga ccgcgcctgc tccctcctgc ttgcccaagg ccgggcaagt catccccgct
      721 ctgcttcgag aggccccgtt ttccagcgtg attgcgccga cactgctctg tgggtttctc
      781 ttcttggcgt gggttgctgc tgaggttcca gaggagagca gcaggatggc cgggagcgga
      841 gccaggagtg aggaaggccg ccggcagcat gccttcgtcc cggaaccttt tgatggggcc
      901 aatgtcgtcc caaacctctg gctgcacagc tttgaagtca tcaatgacct caaccattgg
      961 gaccatatca ccaagctaag gttcctgaaa gagtccctca gaggagaggc cctgggtgtc
     1021 tacaataggc tcagtcccca ggaccaggga gactatggga ctgtgaaaga ggccctcctg
     1081 aaggcctttg gggtccctgg ggctgccccc agccacctgc ccaaagagat cgtctttgcc
     1141 aacagcatgg gtaagggcta ctatctcaag gggaagattg gcaaagtgcc cgtgaggttc
     1201 ctggtggact ctggggccca ggtctctgtg gtccacccaa acttgtggga ggaggtcact
     1261 gatggcgatc tggacaccct gcagcccttt gagaatgtgg taaaggtggc caatggtgct
     1321 gaaatgaaga tcctgggtgt ctgggataca gcggtgtccc taggcaagct gaagctgaag
     1381 gcacagttcc tagtggccaa tgcgagtgcc gaggaagcca tcattggcac tgatgtgctc
     1441 caggaccaca atgctatcct ggactttgag caccgcacat gcaccctgaa agggaagaag
     1501 tttcgccttc tgcctgtggg agggtccctg gaagatgagt ttgacctgga gctcatagag
     1561 gaggacccct cctcagaaga agggcggcag gagctatccc actgagaagc caccttttct
     1621 ttaacctcct aaatattggt gggaagaccc accgctgtgg ggggggttgc atatcctcat
     1681 gggggtcact gggcttggcc agtctgctta tcaactcttg ctcttctctc ccctttgcct
     1741 ccctctgcag gggccttaat ctgcccctgg taggggaggc ttccactgaa caggcacagg
     1801 tgagggagag caggctggct tagagggaca gggtccccat ggtcatcaag ctgctgttga
     1861 tgacaaagac tcaaaggctg gaagagctcc caaggaagct agaaatgctt gtctttgaaa
     1921 gaactgtggg accccttcag attccctgag gtatggcttg gtcactctca ggtcctcaaa
     1981 gcctgtctta gttgggctgg gtcctagctg cagggtcttt gtgagggtca cagttgctct
     2041 gggacacctc cctgaagagc ctttccacct gtacaatcgt attttctttc tgtcatttgc
     2101 tttgaagccc attgtgcctt atgccaataa ttcaattgct gcaaacacca ataaagattg
     2161 attcatgg
//

LOCUS       NM_153186               5263 bp    mRNA    linear   PRI 16-FEB-2005
DEFINITION  Homo sapiens ankyrin repeat domain 15 (ANKRD15), transcript variant
            2, mRNA.
ACCESSION   NM_153186
VERSION     NM_153186.3  GI:59859876
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5263)
  AUTHORS   Sarkar,S., Roy,B.C., Hatano,N., Aoyagi,T., Gohji,K. and Kiyama,R.
  TITLE     A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a
            growth suppressor of renal cell carcinoma
  JOURNAL   J. Biol. Chem. 277 (39), 36585-36591 (2002)
   PUBMED   12133830
  REMARK    GeneRIF: Kank is localized to 9p24 and plays a role in cell growth
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL039663.1, AK025428.1,
            AL833161.1 and BX648931.1.
            On Feb 16, 2005 this sequence version replaced gi:47157333.
            
            Summary: This gene encodes a protein containing four ankyrin repeat
            domains in its C-terminus. The suggested role for this protein is
            in tumorigenesis of renal cell carcinoma. Two alternatively spliced
            transcript variants encoding different isoforms have been
            identified.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and the
            5' coding region, compared to variant 1. The resulting isoform (b)
            has a shorter N-terminus, compared to isoform a.
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.3"
     gene            1..5263
                     /gene="ANKRD15"
                     /note="synonyms: KANK, KIAA0172, MGC43128"
                     /db_xref="GeneID:23189"
                     /db_xref="MIM:607704"
     CDS             790..4374
                     /gene="ANKRD15"
                     /note="isoform b is encoded by transcript variant 2;
                     kidney ankyrin repeat-containing protein;
                     go_function: GTP binding [goid 0005525] [evidence IEA];
                     go_function: GTPase activity [goid 0003924] [evidence
                     IEA];
                     go_process: immune response [goid 0006955] [evidence IEA];
                     go_process: negative regulation of cell cycle [goid
                     0045786] [evidence IEA]"
                     /codon_start=1
                     /product="ankyrin repeat domain protein 15 isoform b"
                     /protein_id="NP_694856.1"
                     /db_xref="GI:23510377"
                     /db_xref="GeneID:23189"
                     /db_xref="MIM:607704"
                     /translation="METRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGS
                     GNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHL
                     QHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCG
                     VRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQA
                     LEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMR
                     NCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQEL
                     QAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGIS
                     CQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEE
                     SVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVP
                     RTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRV
                     KDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACG
                     PPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTL
                     LAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKI
                     TGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLT
                     DDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSD
                     ESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQEC
                     EPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKS
                     AIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCN
                     VDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGR
                     IDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTA
                     LSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD"
     polyA_signal    5222..5227
                     /gene="ANKRD15"
     polyA_site      5242
                     /gene="ANKRD15"
ORIGIN      
        1 agagcctctc tgtagagatg cttaaagtgc tagctttatt taaaaatcag ctggcaaagc
       61 gggagtgaag aacacacatt ttcagaagat accggtttcc tgttttcatt aagaaaacag
      121 ggaatgcgga acagctgagt gcggcggggg tggtgtcact gcagccggag ggagacctcg
      181 ccggtgaaag ctcagcctat ggcatccgag cgtggccggc caagtttaca cgaatgttga
      241 aacttctcct cacggggtga ggatcgaggg cgcccgaggc cgggtccggc tgagctggag
      301 cgagctgtgc ggggcagcgc gggctggcgg ggagcgcggc gggcgccacg tggaaaagca
      361 ggtgatattc tcagtggaga ccaggacaag gaacagaaag acccttactt tgtggagacc
      421 ccctatggtt atcaactaga cttagatttc ctcaaatatg tggatgacat acagaaggga
      481 aataccatca aaagactgaa catccagaag aggcggaagc cgtccgtgcc atgcccagaa
      541 cccaggacca catctggtca gcaaggtata tggacttcca ctgaatccct ctcatcctcc
      601 aacagtgatg acaacaagca gtgccccaac ttcctcatag ccagaagtca agttacatca
      661 actccaatct caaagccacc tccccctctg gagacctcac tcccttttct taccatccca
      721 gaaaatcgac agctgccacc tccctcacca caactcccaa agcataacct tcatgtcacc
      781 aagacactga tggagacccg gagaagactg gaacaggaga gagccaccat gcagatgaca
      841 ccgggtgagt tcagaaggcc caggctggcc agttttggag gcatgggcac cacaagctcc
      901 ctcccttctt ttgtgggttc tggaaaccac aatcctgcca agcaccagct tcagaatgga
      961 taccaaggta atggggatta tggtagctat gccccagctg ctcccaccac ttcctccatg
     1021 gggagctcca tccgccacag ccccctgagc tcagggatct ccaccccagt gaccaacgtg
     1081 agccccatgc acctgcagca catccgcgag cagatggcca ttgctctgaa acgcctgaag
     1141 gagctggagg agcaggtgcg aaccatccct gtgctccagg taaagatctc tgtcttgcaa
     1201 gaagagaaaa ggcagttggt ctcacagctg aaaaaccaaa gggctgcatc ccagatcaat
     1261 gtctgtggtg tgaggaagcg gtcctatagt gcggggaacg cctcccagct ggaacagctc
     1321 tcccgggccc gaagaagtgg cggggaatta tacattgact atgaggagga agaaatggag
     1381 accgtagaac agagcacgca gaggataaag gagttccggc aacttacagc agacatgcaa
     1441 gccctggagc agaagatcca ggacagcagc tgtgaggcct cctcagagct cagggagaat
     1501 ggagagtgcc ggtctgtggc tgtgggtgcc gaggagaaca tgaacgacat cgtcgtgtac
     1561 cacagaggct ccaggtcctg taaggatgca gctgtaggga cacttgttga gatgagaaat
     1621 tgtggggtca gcgtgacaga ggccatgctt ggagtgatga ctgaagctga caaagaaatt
     1681 gagctgcaac agcagaccat agaatccttg aaggaaaaga tctatcgcct agaagtacag
     1741 cttagagaaa ccacccatga ccgggagatg actaaactga aacaagagct gcaggctgct
     1801 ggatcgagga aaaaggttga caaagccacg atggcccagc cgcttgtttt cagtaaggtg
     1861 gtggaggcag tggtgcagac cagagaccaa atggtcggca gtcacatgga cctggtggac
     1921 acgtgtgttg ggacctccgt ggaaacaaac agtgtaggca tctcctgcca gcctgaatgt
     1981 aagaataaag tcgtagggcc tgagctgcct atgaattggt ggattgttaa ggagagggtg
     2041 gaaatgcatg accgatgtgc tgggaggtct gtggaaatgt gtgacaagag tgtgagtgtg
     2101 gaagtcagcg tctgcgaaac aggcagcaac acagaggagt ctgtgaacga cctcacactc
     2161 ctcaagacaa acttgaatct caaagaagtg cggtctatcg gttgtggaga ttgttctgtt
     2221 gacgtgaccg tctgctctcc aaaggagtgc gcctcccggg gcgtgaacac tgaggctgtt
     2281 agccaggtgg aagctgccgt catggcagtg cctcgtactg cagaccagga cactagcaca
     2341 gatttggaac aggtgcacca gttcaccaac accgagacgg ccaccctcat agagtcctgc
     2401 accaacactt gtctaagcac tttggacaag cagaccagca cccagactgt ggagacgcgg
     2461 acagtagctg taggagaagg ccgtgtcaag gacatcaact cctccaccaa gacgcggtcc
     2521 attggtgttg gaacgttgct ttctggccat tctgggtttg acaggccatc agctgtgaag
     2581 accaaagagt caggtgtggg gcagataaat attaacgaca actatctggt tggtctcaaa
     2641 atgaggacta tagcttgtgg gccaccacag ttgactgtgg ggctgacagc cagcagaagg
     2701 agcgtggggg ttggggatga ccctgtaggg gaatctctgg agaaccccca gcctcaagct
     2761 ccacttggaa tgatgactgg cctggatcac tacattgagc gtatccagaa gctgctggca
     2821 gaacagcaga cactgctggc tgagaactac agtgaactgg cagaagcttt cggggaacct
     2881 cactcacaga tgggctccct caactctcag ctcatcagca ccctgtcgtc tatcaactct
     2941 gtcatgaaat ctgcaagcac tgaagagctg aggaaccctg acttccagaa aaccagtctg
     3001 ggtaaaatca caggcaatta tttgggatat acctgtaagt gtgggggcct tcagtcagga
     3061 agtcccttaa gctcccagac atcccagcct gagcaagaag tggggacctc agaaggaaag
     3121 ccaatcagca gcctggatgc cttccccact caggaaggta cgctgtctcc agtgaacctg
     3181 acagacgacc agatcgccgc tggcctctat gcatgtacaa acaatgaaag tacactgaag
     3241 tccatcatga agaagaaaga tggtaacaaa gattcaaatg gcgcaaaaaa gaatcttcag
     3301 tttgttggca ttaatggagg gtatgaaaca acttcaagtg atgattccag ctcagatgaa
     3361 agctcttctt ccgagtcaga tgacgagtgt gatgtcattg agtatcctct tgaagaagag
     3421 gaggaggagg aggatgaaga cactcgggga atggcagaag ggcaccatgc agttaatatt
     3481 gaaggtttga agtctgccag ggtggaagat gaaatgcagg ttcaagaatg tgaacctgag
     3541 aaggtggaaa tcagagagag gtatgaatta agtgaaaaga tgttgtctgc atgcaactta
     3601 ctgaaaaata ctataaatga ccccaaagct ttgaccagca aagatatgag gttctgtctg
     3661 aacaccctcc agcacgagtg gttccgcgtg tccagtcaga agtcagccat tccagccatg
     3721 gtgggggact acatagctgc ttttgaggcc atttccccag atgtcctccg ctatgtcatc
     3781 aacttggcag acggcaacgg caacacagcc ctccattaca gcgtgtccca ctccaacttc
     3841 gagattgtga agctgctgtt agatgccgat gtgtgtaatg tggatcacca gaacaaggca
     3901 ggctacaccc ccatcatgtt ggcggccctc gccgctgtgg aagcagagaa ggacatgcgg
     3961 attgtggaag aactcttcgg ctgtggggat gtgaatgcca aagctagtca ggcgggacag
     4021 acggccctca tgctggcggt cagtcacgga cggatagaca tggtgaaggg ccttctggcc
     4081 tgtggggctg atgtcaacat ccaggatgac gagggctcca cggccctcat gtgtgccagc
     4141 gagcacgggc acgtggagat tgtcaagctg ctgctggccc agcccggctg caacggtcac
     4201 ctagaggaca acgatggcag cactgcgctc tcaatcgccc tggaagcagg acacaaggac
     4261 atcgctgttc ttctgtatgc ccatgtcaac tttgcaaaag cccagtctcc gggcacccct
     4321 aggcttggaa ggaagacgtc tcctggcccc acccaccgag gttcatttga ttgattgtat
     4381 gcaaatagcc ctttatttac atgccactat taagctgcta attgttcctg ttggggtgac
     4441 agatactgaa tgtatacgta ttgtgcctga gctcaccagc aaacagaagc atcaagccca
     4501 ggggtaaagg ctgaagcttt cacagtgcag agactgctag cctgggcaca cacacctcct
     4561 ttctggccgt cttctgtgta gggcacactt taacccagtc tctgttgctg ttgagtctct
     4621 gctccgtttt gtacagtcac agggaattct gatctgaagg ggcaccttct gttcactccc
     4681 acaaagtggt gtctggttct cactgagacg ttttaagatt tttccacaaa tatttatatg
     4741 tactaaatgt ggaaccatta gaaagttctt ccaaaatctc attccagcat agttttggat
     4801 ttttcttttg tcttatttta aaataaggaa gtcgagatga ctttgatcat tggtaacttg
     4861 ggcctgggcc agacaaagta taaaacttac aaaagaatat tctcatttgg tcttaactag
     4921 gtagatgtaa tatatgactt tttataaaaa gggtatctat atgaacttga cacagtattt
     4981 tcagcttttg tattccatac taaagccatg aagaactaca cgtaacatca tcatttgtat
     5041 taattgcaca actccaatgc taaaggttgg attgtgttag aggaatcggc tctgtatttg
     5101 cctctagaga aacacagtgt tctctttgta tttatggatt cctttttacc gtgtcacatt
     5161 tactttggtc ctctatgtat ttaaatgttt gaagtgcctt agactcttgc catattttca
     5221 aaataaaatt ccattaagct ctaaaaaaaa aaaaaaaaaa aaa
//

LOCUS       NM_153367               4947 bp    mRNA    linear   PRI 03-SEP-2004
DEFINITION  Homo sapiens chromosome 10 open reading frame 56 (C10orf56), mRNA.
ACCESSION   NM_153367
VERSION     NM_153367.1  GI:23503314
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4947)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC028617.1.
FEATURES             Location/Qualifiers
     source          1..4947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..4947
                     /gene="C10orf56"
                     /note="synonym: FLJ90798"
                     /db_xref="GeneID:219654"
     CDS             190..915
                     /gene="C10orf56"
                     /codon_start=1
                     /product="chromosome 10 open reading frame 56"
                     /protein_id="NP_699198.1"
                     /db_xref="GI:23503315"
                     /db_xref="GeneID:219654"
                     /translation="MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPVP
                     TAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASPYGSLNNIA
                     DGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPY
                     QGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQ
                     SKEHPQHLCEKCKVLGYYCRRVQ"
ORIGIN      
        1 agcggagtag gggggaggcg gcggcagcgg cagcggctgc gggcagcgcg cggggcgcag
       61 ggcgcggggc gatcaccgtc ggggctcggg aggcgggcag tgggcacagg ctccccggtg
      121 cccgcccctc cgctgcggag gggggccgcg agcgggcggc cggggagggg ccggcaccgc
      181 cgccacaaaa tgagcctgct gtcggccatc gacacgagcg ccgcctcggt gtaccagccc
      241 gcccagctgc tcaactgggt ctacctgtcg ctgcaggaca cgcaccaggc tagcgccttc
      301 gatgccttcc ggcccgtgcc gaccgccggc gccgcacccc cggagctggc cttcggcaag
      361 ggccgccccg agcagctggg ctcgcccctg cactccagct atctcaacag cttcttccag
      421 ctgcagcgcg gagaggcgct gagcaacagt gtgtacaagg gcgcctcacc ctatggctcc
      481 ctcaacaaca tcgccgatgg cctcagctcc ctcaccgagc acttctcaga cctgaccctc
      541 acctccgagg ctcgcaagcc cagcaagcgg cccccaccca actacctgtg ccacctgtgc
      601 ttcaacaaag gacactacat caaggactgc ccccaggcac gccccaaagg cgagggcctg
      661 actccatacc agggcaaaaa gcgctgcttc ggcgagtaca agtgtcccaa gtgcaagaga
      721 aaatggatga gcgggaactc ctgggccaac atggggcagg agtgcatcaa gtgccacatc
      781 aacgtgtatc cacacaagca gagacccctg gagaagcccg acggcctgga cgtgtccgac
      841 cagagcaagg agcacccgca gcacctctgc gagaagtgca aggtcctggg ctactactgc
      901 cgtcgcgtgc agtgacgggc tgcccgcccg cacccagagc caccccccgc cagcccgagg
      961 agacgctgct tccctgtgct actccgaggg gctgcgtgtc gccctgtgca tggggtgccc
     1021 tcgcaggcct gcggggctgg gccgggggct cttagcgtcc ttgtcttgtg tgtgttgaca
     1081 aacagtgtta ctgacattgc tgccccccac aggccaggga aagcagggag tctggggctt
     1141 tttgcaggcg ggcctggggt ctcagtggag gggacaaagg caagcaaaag cccatgtcca
     1201 ggagccctgg gtgtccccac aggctcgcct ctgagagcct ctttggggtg agcagccttg
     1261 tattggccac aggtgcacta aattgactgt gaatcccaaa cctccccaga ccagccaggc
     1321 cgcctgcccc cacccagaac cttccggttt gccctgtatg gaaagccact ctcggaaatc
     1381 cctctttcct gagtcagcaa tcgtggcaag gggacatgtg ttccaacagc ggctggggag
     1441 tggacctctc tgtcccttgc ccaccttaag ccccaaatcc ggaccccctc tgacatcact
     1501 ggcattgcac ctgggtgtgc ccccctcccc acgctatgga cccagatagg aggggttagg
     1561 catgggggag gcacagaatg ctggagagat gcgtcctggt gaacgtgggg cagcccctcc
     1621 cacgaccccc accagactgc cttaggtttt gtcagcccca ctccctttcc ttcccctctg
     1681 cctcccaccc actctggggg tccacatcaa gatagctggg cccagtgtgg aagcccagcg
     1741 tgtctgttct agcagaaagg acacaagcct ggtgttctgg agacctcggc tcaagtcttt
     1801 gccctgctgc cgacgcattg tgtcaccttg ggcaaggact tcgcatctcc aggcctcagt
     1861 ttccccatta gttaaatgac agcataacac tagagagcag agggcccatt tcagctctgt
     1921 tgttctggga ttcaggctgg ccggtgctgt gtcctggagc tttatttggg gagtttcacc
     1981 cagaatggtg ggagaaacct cccaggtgcc aggtaccccg catcgtgacc cttcacttgg
     2041 tgtcttagga agtcaagctg agggatgctg agtcctcccc tgctggcccc tgcagcccca
     2101 gccctgcttt tcatccccca cccctgcaaa catggaggag ccccctcctt ctcacctcgg
     2161 tctcctagcc cctgacatgg agaagcctga gacaagccac agaacccctc ttttctaaaa
     2221 tggagacaat aatttcctac ctcccaaggg agcagagagg cctcgtggca cgtccgtggc
     2281 cagggagccc actgtcctgg ctggcggcgg gatcgtgcgc tcctctgtct cccggatgag
     2341 aagccccgtt tccatggtct tgacccttcc tttctcccgg ctgtcagaac tgggtctctt
     2401 gattttgccc ctacattatg cctctgtggg aaaaaaaaaa aatcagacca agaaatgagc
     2461 ctgaaattca gtgtttacca tggctcaagg atgcccatct ggtgtccagt tgccttttgt
     2521 attcaaatga aaatgctttg tacaactgag gagttacagt gaagtgttaa ccaggggtcc
     2581 agggagcgag ttgaaaagat ggagtgagtg tatttgcagc cagggagctg cagggtggat
     2641 ttgaggggcc ataccctctg agcacttaaa aaaggtattt gctccaggcc aggcagcagg
     2701 ctgtggacac ccttgccacc actggggact gccactgagg actccccgag cacgttgttc
     2761 cccgtcttct ccaaggtgtt gaggtgagct ggggttggcc ccggcccagg cttctgtccc
     2821 aaggagaagc tgccactgac agtcatccta ccgcactgct aaagagaatg ttcgcagtgg
     2881 tgggcagcgt gcctgtgcca acccttccag ggacccggcc atgggggacc ttggcccaag
     2941 gatgcctggg gcctgccagc tgtgctgcaa aggtgggggg cccacaccct aaaactaacc
     3001 caggccccag accactggag gccagggctt ccctgcacgg gctaagggga gttgggatat
     3061 caccccaaag tgaccttgcc agtgagctgt tcagcaggta gccactgccc tgccatctgt
     3121 gcagagccag ccaccttggg ggctggggtt cccgctttga ggcccacctt ccatactccc
     3181 cttgactcgg ctctggctga actggggaac tctcttgtgg tcagcaaagc ccctgccatg
     3241 caggccaggt gccattgaga attaagtgct cagagggcca ggagcccagg ggatgggaaa
     3301 gtgtgtggtt ttagtacgtt caaaagggac aatcgcttgc agttggtaga tctagcgatc
     3361 tagttgggag ataatggtgt ttaccccata tgaagtattc aatagttcta cttgtgaatt
     3421 tgtatttatt ttgagttata cttgacacag aattcctttt ttaaaaaaat atgtgtgtat
     3481 tttggaaaaa aaattcatag atgttaaaat ttctgcatgg ttaccagttt ttctcacaac
     3541 actgaatttg gtagcttttc ccgaaaaaat cttcacagta attttttgtc tgtatatatt
     3601 tgagggcctt ttttttaaaa aaaaaaaaga aaagaaaaat ataattgttt gatttttgag
     3661 attaaaacaa acaaaaagag aggcattttc aaaatttcag aactttcagg agggcaagag
     3721 aatatcaaac aaagatttct ggaagtattt tgccaacctt ctggttgagc tgcaagaaaa
     3781 tatttatggt gagaactttt ctgtttcccg ttattgggtt tttggttggt ttttgtttgt
     3841 tttttactat gctttggtct gtaaaaatat gcaactgaac tacattcaga aggaaatatt
     3901 gtctacatag aatattatat gaagttggta cataattctg atgaggaaaa aaaatctttg
     3961 caattcttta agccatattg ttgtttttct gtgttgtttt ccctggatga aaatatcagt
     4021 attaagtaga cagcatatta ttcaagtgtt tagacttatt aatatgttct tgtcctgtat
     4081 ttatacatat gtgtattttg gaaagtattg ccttttttaa gggaagctat aattcgatac
     4141 atagtgaaaa agggaatggt gacccctttg tgcctcttcc actgaggata acaaacagca
     4201 ttgtaatcca ttctcttgca ccttcttctt cttatcttgt tattacggtt ttattaattt
     4261 tgtagaggga cagggagtgg gcaaggggaa gaagcagctt atttgactaa ccagcccctc
     4321 tgtggtccac cagcgtcttg gcttggtggg agggctctca atcagcaggg ccccaggagg
     4381 gaagaagaag tggggcaaag cctggcctcg ccgctcggga gctttgccat ctgagccacg
     4441 cctcctccag gccatgctcc ttgaacttgg aaatgtcaac cggagccctt acaccagccc
     4501 tccagcatct aatagacttg aatctactct aaacgaatat ttaatccaac ctcactacat
     4561 tgtagctcag tccaacgact aaccctgaaa tgggggtgtt ccagccttca gcgagatggc
     4621 caagcggtcc cctgggggct gtggcagcgg gcttatcctt ctctgttgcc aaccttgccg
     4681 tccgacctcc tccgccccca tgcggtgacc ccgtccgtgt ctgtgtctgt ccatacgtgt
     4741 gagtccagct aaaaagacaa aacagaaccc gtgggcccag ctcggaaggt gcgtggagaa
     4801 ggctccgacg tctccgaagt gcagcccttg ggatggcatt ccgttgtgtg ccttattcct
     4861 ggagaatctg tatacggctc gcctatagaa atatagcctc ttcatgctgt attaaaagga
     4921 cttttaaaag caaaaaaaaa aaaaaaa
//

LOCUS       NM_172105               3077 bp    mRNA    linear   PRI 20-DEC-2004
DEFINITION  Homo sapiens eyes absent homolog 4 (Drosophila) (EYA4), transcript
            variant 4, mRNA.
ACCESSION   NM_172105
VERSION     NM_172105.1  GI:26667256
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3077)
  AUTHORS   Pfister,M., T, Thiele,H., Haack,B., Blin,N., Zenner,H.P.,
            Sziklai,I., N and Kupka,S.
  TITLE     A 4-bp insertion in the eya-homologous region (eyaHR) of EYA4
            causes hearing impairment in a Hungarian family linked to DFNA10
  JOURNAL   Mol. Med. 8 (10), 607-611 (2002)
  MEDLINE   22366340
   PUBMED   12477971
  REMARK    GeneRIF: Mutation analysis of the EYA4 gene, which maps to 6q22.3,
            revealed an insertion of 4 bp (1558insTTTG) in affected family
            members with hereditary hearing impairment
REFERENCE   2  (bases 1 to 3077)
  AUTHORS   Wayne,S., Robertson,N.G., DeClau,F., Chen,N., Verhoeven,K.,
            Prasad,S., Tranebj, Morton,C.C., Ryan,A.F., Van Camp,G. and
            Smith,R.J.
  TITLE     Mutations in the transcriptional activator EYA4 cause late-onset
            deafness at the DFNA10 locus
  JOURNAL   Hum. Mol. Genet. 10 (3), 195-200 (2001)
  MEDLINE   21096895
   PUBMED   11159937
REFERENCE   3  (bases 1 to 3077)
  AUTHORS   Borsani,G., DeGrandi,A., Ballabio,A., Bulfone,A., Bernard,L.,
            Banfi,S., Gattuso,C., Mariani,M., Dixon,M., Donnai,D., Metcalfe,K.,
            Winter,R., Robertson,M., Axton,R., Brown,A., van Heyningen,V. and
            Hanson,I.
  TITLE     EYA4, a novel vertebrate gene related to Drosophila eyes absent
  JOURNAL   Hum. Mol. Genet. 8 (1), 11-23 (1999)
  MEDLINE   99105912
   PUBMED   9887327
REFERENCE   4  (bases 1 to 3077)
  AUTHORS   O'Neill,M.E., Marietta,J., Nishimura,D., Wayne,S., Van Camp,G., Van
            Laer,L., Negrini,C., Wilcox,E.R., Chen,A., Fukushima,K., Ni,L.,
            Sheffield,V.C. and Smith,R.J.
  TITLE     A gene for autosomal dominant late-onset progressive non-syndromic
            hearing loss, DFNA10, maps to chromosome 6
  JOURNAL   Hum. Mol. Genet. 5 (6), 853-856 (1996)
  MEDLINE   96372824
   PUBMED   8776603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y17114.1 and Y17847.1.
            
            Summary: This gene encodes a member of the eyes absent (EYA) family
            of proteins. The encoded protein may act as a transciptional
            activator and be important for continued function of the mature
            organ of Corti. Mutations in this gene are associated with
            postlingual, progressive, autosomal dominant hearing loss at the
            deafness, autosomal dominant nonsyndromic sensorineural 10 locus.
            Four transcript variants encoding four distinct isoforms have been
            identified for this gene.
            
            Transcript Variant: This variant (4) contains an alternate in-frame
            segment in the coding region, compared to variant 1. The resulting
            isoform (d) differs in the C-terminal compared to isoform a.
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23"
     gene            1..3077
                     /gene="EYA4"
                     /note="synonym: DFNA10"
                     /db_xref="GeneID:2070"
                     /db_xref="MIM:603550"
     CDS             441..2360
                     /gene="EYA4"
                     /note="isoform d is encoded by transcript variant 4;
                     deafness, autosomal dominant 10; dJ78N10.1 (eyes absent
                     (Drosophila) homolog 4);
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: hydrolase activity [goid 0016787] [evidence
                     IEA];
                     go_function: magnesium ion binding [goid 0000287]
                     [evidence IEA];
                     go_function: protein tyrosine phosphatase activity [goid
                     0004725] [evidence IEA];
                     go_process: metabolism [goid 0008152] [evidence IEA];
                     go_process: morphogenesis [goid 0009653] [evidence TAS]
                     [pmid 9887327];
                     go_process: visual perception [goid 0007601] [evidence
                     TAS] [pmid 9887327];
                     go_process: regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /codon_start=1
                     /product="eyes absent 4 isoform d"
                     /protein_id="NP_742103.1"
                     /db_xref="GI:26667257"
                     /db_xref="GeneID:2070"
                     /db_xref="MIM:603550"
                     /translation="MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGG
                     GDTPGSSKLEKSNLSSTSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEP
                     LNSSETTATTGDGALDTFTGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTM
                     SAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSG
                     CLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAF
                     GQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPST
                     PIKDLDERTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYA
                     QKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYS
                     FATDGFHAAASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKR
                     DAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGG
                     AFPIENIYSATKIGKESCFERIVSRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSH
                     SDLLALHQALELEYL"
ORIGIN      
        1 ccacgtgaag ttgtcgctgc cttagagagg gggaaagagc tgcgggaaaa gccggggagt
       61 gacgactgcg gcggctgggc gcgctctctc attttctttt cttctccttt cccccctgtc
      121 gcagtccgga gttttggctc ctctcctttc ctcctccccc tcggagccgg cttctccctc
      181 cgccccgctt ctcccccgct tgtgtacgct atttgttgtg gggtggccga aggggatgtc
      241 ctgttttcac cagaggcaca gcgcgaaggg gaaacttcga cactggaagg aacgagaata
      301 aatacttaat tacggacgca ctgaaccgcg gctgggacag acacttcggg aacccgaggc
      361 ggaccgggcg acgagatagt catttttact tgaaggaagc tgcttctact tgggagtggc
      421 aggagaagtg agaaaaccac atggaagact cccaggattt aaatgaacaa tcagtaaaga
      481 aaacgtgcac agaatcagat gtttcacaat ctcagaattc caggtctatg gaaatgcagg
      541 acctagcaag tcctcatact cttgttggag gtggtgatac tccaggtagc tccaaactgg
      601 aaaaatctaa tctcagcagc acatcagtta ctacaaatgg gacaggaggg gaaaacatga
      661 ctgttttaaa cacagcagac tggttgctga gttgcaacac cccctcttct gcaacaatgt
      721 ctcttcttgc agtcaaaaca gagcccttga acagcagtga aaccacagcc acgactggag
      781 atggagcgct tgacactttt actgggtcag taattacaag tagtggctac agccccagat
      841 cagcacatca gtattcccca cagctgtatc cttccaagcc ctatccacac attctttcta
      901 caccagcagc tcaaacaatg tctgcctatg caggccagac tcagtattcg gggatgcagc
      961 agccagccgt ctacacagcc tactcacaga caggacagcc ctacagcttg cccacttacg
     1021 atttgggtgt gatgttgcca gccatcaaga cagagagtgg actttcccaa actcagtccc
     1081 cattacagag tggctgcctc agttacagcc cagggttctc taccccacag ccaggccaga
     1141 caccttattc ttaccaaatg ccaggttcta gttttgcacc atcatctact atttatgcaa
     1201 ataattcagt ttccaattca acgaatttca gtggttcaca acaggattat ccatcctata
     1261 cagcctttgg ccaaaaccag tatgcacagt attattcagc atcaacgtat ggagcgtata
     1321 tgacatcgaa taacacagcc gatggcacac cctcttcaac ctctacttat cagttgcagg
     1381 aatctctccc aggactgact aaccaaccag gagagttcga taccatgcag agtccctcca
     1441 cacccatcaa agatcttgat gagagaacct gtaggagttc tgggtcaaag tccagaggaa
     1501 gaggccggaa aaataatccc tccccgcctc ctgatagtga cctggagcgt gtgtttgtct
     1561 gggatttgga tgaaaccatc attgtttttc actcactgct caccgggtct tatgcacaga
     1621 agtatggcaa ggatcccccc atggctgtaa cccttggact ccgcatggaa gaaatgattt
     1681 ttaatcttgc tgatactcat ttgtttttta atgatttaga ggagtgtgat caagttcata
     1741 tagatgatgt ttcctctgat gataatgggc aggacttaag tacctacagt tttgcaactg
     1801 atggcttcca tgcagctgca agtagtgcaa acctttgttt gccaacaggt gtaagaggag
     1861 gggttgactg gatgaggaag ttggcttttc gttacagaag agtaaaagaa ttatataaca
     1921 cctacaagaa caacgttgga ggactccttg gccctgccaa gagggatgcc tggctacagt
     1981 taagggcaga gattgaaggt ctgacagatt cctggctaac aaatgcactt aagtctttat
     2041 caattattag cactaggagt aactgcataa atgtcttggt aacgacaact caactgatcc
     2101 cagcacttgc gaaggttcta ctctatagtt taggaggtgc tttccccatt gagaatattt
     2161 acagtgcaac taaaataggt aaggaaagct gttttgagcg tatagtgtcc agatttggca
     2221 ctaacataac ttatgttgtg attggagatg gccgagatga ggagcatgcc gctaaccagc
     2281 acaacatgcc cttctggagg atatccagtc actcagacct cctggctctc caccaagcac
     2341 tggaattaga gtatttgtaa ctgtgttctt tagccggaga tccatttttt atatttcaag
     2401 tacactgaat ttttatgtgt gattcaatgc ctctggctct acacatataa attgtcttaa
     2461 tggatgaaat catatttgga ataaaaattc cagaatgaag aattcagatt gctgaatgga
     2521 gttaaacttt agtgctacag aaaagaaact ctatggtctt atatttacaa cactttaatg
     2581 ggttttttaa aaatctgtgg aggttgctgg tacacaccaa atgagtccaa actggaatga
     2641 gcagctttag caaagaactc ttaccctggc aaagcagcaa cacacatgct ccgtctgaca
     2701 aggtggtcaa caacattcct caaaatggga gatcttctca gccctgaggt ttgaatctga
     2761 ctttagccta cctaacccag aaaatctgaa ttggaatgca ctcagactgt ataaggacag
     2821 tcctatttag acatgtaatt tgtgtaaatt attgatgaaa ataatttact gtgactttat
     2881 tagcagctga ctttcaaagt ggatgcaatt tttctttctt ttgttgggga ggggaatggg
     2941 aggggaaatg ggaatataat attgtctctt ttttaagttt ggcaaacaga atgttcatac
     3001 tgatgtgttg tgccttaaag acaagacagc atttgtgtgt tacaatgtaa ctttggttaa
     3061 aatctctgta gataatg
//

LOCUS       NM_173607               2856 bp    mRNA    linear   PRI 23-AUG-2004
DEFINITION  Homo sapiens chromosome 14 open reading frame 24 (C14orf24), mRNA.
ACCESSION   NM_173607
VERSION     NM_173607.2  GI:31377542
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from AK096173.1.
            On Jun 4, 2003 this sequence version replaced gi:27734698.
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     gene            1..2856
                     /gene="C14orf24"
                     /note="synonym: FLJ38854"
                     /db_xref="GeneID:283635"
     CDS             71..712
                     /gene="C14orf24"
                     /codon_start=1
                     /product="chromosome 14 open reading frame 24"
                     /protein_id="NP_775878.1"
                     /db_xref="GI:27734699"
                     /db_xref="GeneID:283635"
                     /translation="MDQEPVGGVERGEAVAASGAAAAAAFGESAGQMSNERGFENVEL
                     GVIGKKKKVPRRVIHFVSGETMEEYSTDEDEVDGLEKKDVLPTVDPTKLTWGPYLWFY
                     MLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAE
                     KQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESKQNPVSVPP"
ORIGIN      
        1 ctcagagact tggctaggcg cggcgcgagg cgggcgctgc ggcgccagca gccctgtggt
       61 ggcgacgacg atggaccagg agccagtggg cggtgtggaa cgaggagaag ccgtcgcagc
      121 ctcgggagct gcggccgccg cggcattcgg ggaatctgca gggcagatga gtaacgaaag
      181 aggctttgaa aatgtagaac tgggagtcat aggaaaaaag aagaaagtcc caaggagagt
      241 catccacttt gttagtggtg aaacaatgga agaatatagc acagatgaag acgaagttga
      301 tggcctggag aagaaagatg ttttgcctac tgttgatccg acaaaactta cctggggtcc
      361 ctacttatgg ttttacatgc ttcgggctgc tacatcaact ctctcagtgt gtgacttcct
      421 tggagagaag attgcatctg ttttgggtat cagcacccca aagtaccaat atgccattga
      481 tgaatattat cggatgaaga aggaggaaga agaagaagaa gaagaaaaca ggatgtctga
      541 agaagcagaa aaacaatatc aacagaataa attgcagact gattccattg ttcagacaga
      601 tcaaccagag acagtgatat ccagctcatt tgtgaatgtc aattttgaaa tggagggaga
      661 cagtgaagta attatggaaa gcaagcaaaa tccagtctct gtcccaccat aaaatgaaat
      721 gactatcaag cttcaaactc ttaagttttt tttttttaat acaaaaactt tcacattctt
      781 tattcagtgg gacttaatac aattatttat attttaaatt attaaagtat ctggaaaggg
      841 aaaatgtttt cttcattttt aggatctatc tagcaaaagc cagatctgaa attcagatat
      901 ttgtactgtt tttactgtgt atagaaatta gtgctttggt tttaaaatga tcttttaaaa
      961 aagttaagga catcctagag ccttaatagt taagaagagt taaattatca agcctatttg
     1021 tgtatttgct ttttttgaaa aaggtaagtt gctgattaag tctaattgga attgataatt
     1081 ccatagtctt agattaaaat gaggatattt tctcctagat tttctcatgt tatgccatgc
     1141 atttatatat ctaaccatta atttcacact aaggatgctt caccatataa taaaaggagc
     1201 aagatggaag cactttgaat tttctttcat tgagaataac tgttttatgt aagaatctgt
     1261 atttataaca ccagatatta agataggctt ccatttttta atgcaagcca cttacttaat
     1321 cttgtattct ttttcaggac tcaaataact agctttgaac ataatattaa aacactactt
     1381 atagaataga tttattaatg ttaataccta gtgaatatcc atgtggcatc ctggttatcg
     1441 gttcagcgtt aatcctatag aaaagtggtt tggaggggat tgggggatag tgggacaggt
     1501 atagatttaa tccatcagga gcaattagat attgtataag gtgcaatgat agcctaatga
     1561 aattacccgt cattcatcat ttagaagtag caacagtgaa gactggacag tttacttgaa
     1621 tctggttggc cactcctcta cctacttggt tatttgtaaa ccttacaaat gtatatattg
     1681 tgaagctaat tttgaaaata ttcctaaata tggccaggta cggtgctcac acctgtaatc
     1741 ccagcacttt gggaggctga agtgggcaga ttacttgagg tcaggagttt gagaccagcc
     1801 tggccaacgt agtgaaaccc cgtctctaca aaaatacaaa aattagccag gcgtggtggt
     1861 gcacgtctgt aatcccagct gctcgggagg ctgaggcagg agaatcactt gaaccaggga
     1921 ggtggaggtt gcagtgagcc aagattgcac cactgcactc cagcctgggc gacagagtga
     1981 gactccatct tggggggaaa aaagtatata tatatacaca cacacagaca cacacacaca
     2041 cacatatatc tctaaatgtg tgtatagaac cttttatcag tataacattg atttataatt
     2101 aaatgtgggt gaggaagaat gtgtggagtg tttcagaaat tttgatctta aaagcctttt
     2161 cagaaactca aagctttcag aaattaatag ttatattaat agccttctaa acagcattaa
     2221 gttttcaatt ttaatatatc tatataaaat atagtgtcaa agaaagtaac atcaatatag
     2281 tgggtctgta atggaaatct gtcaatgaac atgaactgag ttcttcaact acaggttgaa
     2341 ggataattaa acttttcatt aggagtgttc agctacatgg attcatggaa tggtggttca
     2401 tagtaagtga tggtaatctt tttattcatg ggtgtaaacc ctttataact tagtgcttaa
     2461 aatattaatc ttttgattat ataatgtccc atgaattata gtttaccaat agttctaaaa
     2521 catgctaacc tgaccttttc cttctaattt gtttttaact tcattcgaga tagtacctct
     2581 cactcacaga tatttatttg gttatcaagt gaagataggt gtgtctaaaa gtgatcttct
     2641 gaatcctgtc tccctagagg tactagtatc tagagtttac ccagaaaatt ttatgattgt
     2701 aacaaaagga agtagtgact tatgaaggtt ttgtttcttg aattttactt ttgctacttg
     2761 tccaatagtg gctagtttat gtttatcaat atagttattc actgtgcctt aagtttatac
     2821 tttgtttatg caaactataa aatttcccat aaatgt
//

LOCUS       NM_175866               2901 bp    mRNA    linear   PRI 14-DEC-2004
DEFINITION  Homo sapiens U2AF homology motif (UHM) kinase 1 (UHMK1), mRNA.
ACCESSION   NM_175866
VERSION     NM_175866.2  GI:52851453
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2901)
  AUTHORS   Bieche,I., Manceau,V., Curmi,P.A., Laurendeau,I., Lachkar,S.,
            Leroy,K., Vidaud,D., Sobel,A. and Maucuer,A.
  TITLE     Quantitative RT-PCR reveals a ubiquitous but preferentially neural
            expression of the KIS gene in rat and human
  JOURNAL   Brain Res. Mol. Brain Res. 114 (1), 55-64 (2003)
  MEDLINE   22664699
   PUBMED   12782393
  REMARK    GeneRIF: KIS gene was overexpressed in NF1-associated plexiform
            neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs)
            as compared to dermal neurofibroma which suggests a possible
            implication of KIS in the genesis of NF1-associated tumors.
REFERENCE   2  (bases 1 to 2901)
  AUTHORS   Boehm,M., Yoshimoto,T., Crook,M.F., Nallamshetty,S., True,A.,
            Nabel,G.J. and Nabel,E.G.
  TITLE     A growth factor-dependent nuclear kinase phosphorylates p27(Kip1)
            and regulates cell cycle progression
  JOURNAL   EMBO J. 21 (13), 3390-3401 (2002)
  MEDLINE   22088292
   PUBMED   12093740
  REMARK    GeneRIF: We identify the kinase responsible for S10 phosphorylation
            as human kinase interacting stathmin (hKIS) and show that it
            regulates cell cycle progression in response to mitogens.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ536197.1.
            On Sep 30, 2004 this sequence version replaced gi:28467002.
FEATURES             Location/Qualifiers
     source          1..2901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2901
                     /gene="UHMK1"
                     /note="synonyms: KIS, Kist"
                     /db_xref="GeneID:127933"
                     /db_xref="MIM:608849"
     CDS             138..1397
                     /gene="UHMK1"
                     /note="KIS protein kinase; kinase interacting with
                     leukemia-associated gene (stathmin);
                     go_component: nucleus [goid 0005634] [evidence ISS];
                     go_component: cytoplasm [goid 0005737] [evidence ISS];
                     go_function: ATP binding [goid 0005524] [evidence ISS];
                     go_function: RNA binding [goid 0003723] [evidence ISS];
                     go_function: protein binding [goid 0005515] [evidence IPI]
                     [pmid 12093740];
                     go_function: transferase activity [goid 0016740] [evidence
                     IEA];
                     go_function: protein serine/threonine kinase activity
                     [goid 0004674] [evidence ISS];
                     go_process: cell cycle arrest [goid 0007050] [evidence
                     IMP] [pmid 12093740];
                     go_process: autophosphorylation [goid 0046777] [evidence
                     IDA] [pmid 12093740];
                     go_process: peptidyl-serine phosphorylation [goid 0018105]
                     [evidence ISS];
                     go_process: regulation of protein-nucleus export [goid
                     0046825] [evidence IDA] [pmid 12093740]"
                     /codon_start=1
                     /product="kinase interacting stathmin"
                     /protein_id="NP_787062.1"
                     /db_xref="GI:28467003"
                     /db_xref="GeneID:127933"
                     /db_xref="MIM:608849"
                     /translation="MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCG
                     NPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSP
                     NVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLK
                     PRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTE
                     CTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYH
                     LRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYL
                     ENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGR
                     MFDGKFVVATFYPLSAYKRGYLYQTLL"
ORIGIN      
        1 gccgggagtc ggtgaggcgg ctgcaggtcc ctccctgcgg agccgctggt ccggctggcg
       61 gagatgtgac cgcgggcccg gccggcctgc ctcaggcgtc gcgtcagctc ccgtgtccgt
      121 gcccttaacc cacaccgatg gcgggatccg gctgcgcctg gggcgcggag ccgccgcgtt
      181 ttctggaggc cttcgggcgg ctgtggcagg tacagagccg tctgggtagc ggctcctccg
      241 cctcggtgta tcgggttcgc tgctgcggca accctggctc gccccccggc gccctcaagc
      301 agttcttgcc gccaggaacc accggggctg cggcctctgc cgccgagtat ggtttccgca
      361 aagagagggc ggcgctggaa cagttgcagg gtcacagaaa catcgtgact ttgtatggag
      421 tgtttacaat ccacttttct ccaaatgtgc catcacgctg tctgttgctt gaactcctgg
      481 atgtcagtgt ttcggaattg ctcttatatt ccagtcacca gggttgttcc atgtggatga
      541 tacagcattg tgcccgagat gttttggagg cccttgcttt tcttcatcat gagggctatg
      601 tccatgcgga cctcaaacca cgtaacatat tgtggagtgc agagaatgaa tgttttaaac
      661 tcattgactt tggacttagc ttcaaagaag gcaatcagga tgtaaagtat attcagacag
      721 acgggtatcg ggctccagaa gcagaattgc aaaattgctt ggcccaggct ggcctgcaga
      781 gtgatacaga atgtacctca gctgttgatc tgtggagcct aggaatcatt ttactggaaa
      841 tgttctcagg aatgaaactg aaacatacag tcagatctca ggaatggaag gcaaacagtt
      901 ctgctattat tgatcacata tttgccagta aagcagtggt gaatgccgca attccagcct
      961 atcacctaag agaccttatc aaaagcatgc ttcatgatga tccaagcaga agaattcctg
     1021 ctgaaatggc attgtgcagc ccattcttta gcattccttt tgcccctcat attgaagatc
     1081 tggtcatgct tcccactcca gtgctaagac tgctgaatgt gctggatgat gattatcttg
     1141 agaatgaaga ggaatatgaa gatgttgtag aagatgtaaa agaggagtgt caaaaatatg
     1201 gaccagtggt atctctactt gttccaaagg aaaatcctgg cagaggacaa gtctttgttg
     1261 agtatgcaaa tgctggtgat tccaaagctg cgcagaaatt actgactgga aggatgtttg
     1321 atgggaagtt tgttgtggct acattctacc cgctgagtgc ctacaagagg ggatatctgt
     1381 atcaaacctt gctttaatca gtaacctaag gactgtttcc tttttctcct cttccatttc
     1441 ttgggttatt ccacatatga atgcaggact acccccttac cattttaaga aggtacttta
     1501 tacatttatt taatcctact aatgtgcagc cattgcccaa gcagtgactg cgttgcatac
     1561 atttggcact gagtaggaca agacctctca gctatacatt gaggggtttt agagcatcca
     1621 tgtgggcaac ccttttttgt gcgggagagc aggtgttgct cttcagtatg tagcctaaaa
     1681 aaatcttaat tatttcatgg atcatgaagc aaggatgaat aatatcatgt cttggtaaat
     1741 actaacaaat ttgttaggtt tggtgacatc atttacagat tatttcttta tgttgtccag
     1801 tggttcttcc ttattgttga tatccataag ctggcactgg atgctctcag taatgttaag
     1861 taattgtcaa gcagcagtta cctactgtgt tcttaacact gagttgtgaa ttttttctta
     1921 aagcagtact gtagtactga atattccttt aaaggaactg cagtgagcct atctaagttt
     1981 ttttaaatta aggcttttaa aatagaaagc tgatgcttga tcttgcacaa tttttatgtc
     2041 tagtatgtat gcttgagtga atgtgtgagt atgaatgatt agagaaaatt tgagtcagtg
     2101 tactttatag tgtgaatcct gtgagctaat acagtctata cttatttctt ccctacctgt
     2161 ttcacatccg taagatttag gatatacatt ttttgagagg tagtctgtct gatacaatgt
     2221 aaatgacaaa acataattcc tgagaggccc agaacaaact ggagtctagc ctggagttaa
     2281 attgagactt ctaaaatgat tggaacaaag actaagttgt gccagatgta aatcaacccc
     2341 tcttttagtt tactttagac tttgtattag ctcatctttt ttgtagtaaa tctatagttt
     2401 taaggtttct caagatgtgg ctctacctac tatgatgaaa attgaagtgg gtcaaaagaa
     2461 ttagatgtac agtgaaggga aaagaaaaaa aatgggcgaa gagagggtgg aaaataaaag
     2521 gattcttttt tcttcctttc tgtttctcgt atccctgctc cctttttcct ccccttccct
     2581 cattctttgc ctctatcctt agctgaagac aaactagagg agcagcatcc caggtagttt
     2641 ggcttttgac tgcaaggtag ttaagaaagg tgtagatata atgaggtaga agtagaaagg
     2701 aagaaaaact caaagaattc tgaaaaggat tcatagcaac ataatgtgtc cctgagtaga
     2761 ggatgctgct atgcgtgagt tcatggacac aagttgatta catggttttt agaattataa
     2821 ttatggattc ttcttatttc atggtaggtt gtctttaaag atataaaaat taggatgcct
     2881 ttatgaagca ctgattatac c
//

LOCUS       NM_178439               2402 bp    mRNA    linear   PRI 27-OCT-2004
DEFINITION  Homo sapiens germ cell-less homolog 1 (Drosophila) (GCL), mRNA.
ACCESSION   NM_178439
VERSION     NM_178439.3  GI:34222268
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Masuhara,M., Nagao,K., Nishikawa,M., Kimura,T. and Nakano,T.
  TITLE     Enhanced degradation of MDM2 by a nuclear envelope component, mouse
            germ cell-less
  JOURNAL   Biochem. Biophys. Res. Commun. 308 (4), 927-932 (2003)
   PUBMED   12927808
  REMARK    GeneRIF: mGCL-1 is a factor modulating MDM2-p53 axis by enhanced
            degradation of MDM2
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Kleiman,S.E., Yogev,L., Gal-Yam,E.N., Hauser,R., Gamzu,R.,
            Botchan,A., Paz,G., Yavetz,H., Maymon,B.B., Schreiber,L.,
            Barzilai,S., Amariglio,N., Rechavi,G. and Simon,A.J.
  TITLE     Reduced human germ cell-less (HGCL) expression in azoospermic men
            with severe germinal cell impairment
  JOURNAL   J. Androl. 24 (5), 670-675 (2003)
   PUBMED   12954656
  REMARK    GeneRIF: Germ cell-less protein is not essential for the
            chromosomal events of meiosis but might be involved in later
            aspects of spermatogenesis.
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Holaska,J.M., Lee,K.K., Kowalski,A.K. and Wilson,K.L.
  TITLE     Transcriptional repressor germ cell-less (GCL) and barrier to
            autointegration factor (BAF) compete for binding to emerin in vitro
  JOURNAL   J. Biol. Chem. 278 (9), 6969-6975 (2003)
   PUBMED   12493765
  REMARK    GeneRIF: GCL binds directly to emerin, and the emerin-repressor
            complexes might be regulated by barrier to autointegration factor
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J. Cell. Sci. 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC007420.2.
            On Aug 26, 2003 this sequence version replaced gi:31340740.
            
            Summary: This gene encodes a nuclear envelope protein that appears
            to be involved in spermatogenesis, either directly or by
            influencing genes that play a more direct role in the process. This
            multi-exon locus is the homolog of the mouse and drosophila germ
            cell-less gene but the human genome also contains a single-exon
            locus on chromosome 5 that contains an open reading frame capable
            of encoding a highly-related protein.
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2402
                     /gene="GCL"
                     /note="synonyms: GMCL1, FLJ13057"
                     /db_xref="GeneID:64395"
     CDS             208..1755
                     /gene="GCL"
                     /note="germ cell-less homolog (Drosophila);
                     go_component: nucleus [goid 0005634] [evidence IEA];
                     go_function: protein binding [goid 0005515] [evidence
                     IEA];
                     go_process: spermatogenesis [goid 0007283] [evidence IEA]"
                     /codon_start=1
                     /product="germ cell-less"
                     /protein_id="NP_848526.1"
                     /db_xref="GI:30410765"
                     /db_xref="GeneID:64395"
                     /translation="MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFC
                     YCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLF
                     LNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVE
                     ALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYT
                     SAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLFVMQVEMDIY
                     TALKKWMFLQLVPSWNGSLKQLLTETDVWFSKQRKDFEGMAFLETEQGKPFVSVFRHL
                     RLQYIISDLASARIIEQDAVVPSEWLSSVYKQQWFAMLRAEQDSEVGPQEINKEELEG
                     NSMRCGRKLAKDGEYCWRWTGFNFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRR
                     SIAFRLRLASFDSSGKLICSRTTGYQILTLEKDQEQVVMNLDSRLLIFPLYICCNFLY
                     ISPEKKN"
ORIGIN      
        1 ggtgctgcgg tgctagagcg cggcgcgacc ggacgctgcg ggcggggaag aggatggaga
       61 ctgtggcgtc cgctgcaacg gttggggctg cgcgtgagaa ggtggcggtg taggcacctg
      121 cgctcgggga aggctggcgg cggcggccga gccatggcgg gagaccccct tctctgggct
      181 ccctgaagtc tcggggagcc gtgacccatg ggatcgttga gcagccgggt gctgcgccag
      241 ccaagaccag cccttgccca gcaggcgcag ggtgccaggg cggggggctc ggcccggagg
      301 ccggacactg gagacgatgc ggcgggccac ggattctgtt actgtgcggg cagccacaag
      361 cgcaagcgga gcagcgggtc cttctgctac tgtcaccctg actcggagac ggacgaggat
      421 gaggaggagg gggacgagca gcagcggctc ctcaacaccc ctcgaaggaa aaaattaaag
      481 agtacatcta aatatattta tcaaacatta tttttgaatg gtgaaaacag tgacattaag
      541 atttgtgctc taggagaaga atggagctta cacaaaatat atttatgtca atctggctac
      601 ttttctagta tgttcagtgg ttcttggaaa gaatccagca tgaatattat tgaactggag
      661 attcctgacc agaacattga tgtagaagca ctgcaggttg catttggttc actgtatcga
      721 gatgatgtct tgataaagcc cagtcgagtt gttgccattt tggcagcagc ttgtttgctg
      781 cagttggacg gtttaataca gcagtgtggt gagacaatga aggaaacagt taatgtgaaa
      841 actgtatgtg gctattacac atcagcaggg acctatggat tagattctgt aaagaaaaag
      901 tgccttgaat ggcttctaaa caatttgatg actcaccaga atgttgaact ttttaaagaa
      961 ctcagtataa atgtcatgaa acagctcatt ggttcatcta acttatttgt gatgcaagtg
     1021 gagatggata tatacactgc tctaaaaaag tggatgttcc ttcaacttgt gccttcttgg
     1081 aatggatctt taaaacagct tttgacagaa acagatgtct ggttttctaa acagaggaaa
     1141 gattttgaag gtatggcctt tcttgaaact gaacaaggaa aaccatttgt gtcagtattc
     1201 agacatttaa ggttacaata tattatcagt gatctggctt ctgcaagaat tattgaacaa
     1261 gatgctgtag taccttcaga atggctctct tctgtgtata aacagcagtg gtttgctatg
     1321 ctgcgggcag aacaggacag tgaggtgggg cctcaagaaa tcaataaaga agaactagag
     1381 ggaaacagca tgaggtgtgg tagaaagctt gccaaagatg gtgaatactg ctggcgttgg
     1441 acaggtttta acttcggctt cgacctactt gtaacttaca ccaatcgata catcattttc
     1501 aaacgcaata cactgaatca gccatgtagc ggatctgtca gtttacagcc tcgaaggagc
     1561 atagcattta gattacgttt ggcttctttt gatagtagtg gaaaactaat atgtagtaga
     1621 acaactggct atcaaatact tacacttgaa aaggatcagg aacaagtggt gatgaacttg
     1681 gacagcaggc ttctgatctt ccctttatat atctgctgta acttcttgta tatatcacca
     1741 gaaaaaaaga attgaaaata atcgtcaccc agaaaatcca gaaaactgaa gatttcatca
     1801 gttggaaaca gtagcacttt gaaaactttt taggccagct ttaatttaat ggccctactg
     1861 atattcacat cgaaggtgac taacaatgac aaaggcctta tgaactgtac agacaataca
     1921 gaagattatt cttatcctca ttgcatttct atgcatatgc gtaagaacat tttaaagcca
     1981 agaaaatatc tgtcaaacca tttctgttag aacgatgtca attcatgctt ttaatttagc
     2041 atcaatagaa aattgctgta ggtaaatctc acatttatct gcaacaaaat atagatttaa
     2101 tttttagctt aaactttgtt tctaccttat gttagtggac ctcagttatc catctgtaaa
     2161 tttcttttta tttggctaaa ataatctaaa agaataattt ggttggccaa ttagaaatgc
     2221 ctttttcagt tggtgtattg aaagctttcc tttaacattt tcacctgctc attgtgattc
     2281 ctccttttag tctaatatct ttccaggtca tacttgtttt taatcattaa atattttctt
     2341 cctggtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aa
//

LOCUS       NM_178507               1957 bp    mRNA    linear   PRI 21-AUG-2004
DEFINITION  Homo sapiens NS5ATP13TP2 protein (NS5ATP13TP2), mRNA.
ACCESSION   NM_178507
VERSION     NM_178507.2  GI:31341888
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PREDICTED REFSEQ: The mRNA record is supported by experimental
            evidence; however, the coding sequence is predicted. The reference
            sequence was derived from BC047726.1.
            On Jun 3, 2003 this sequence version replaced gi:30425437.
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1957
                     /gene="NS5ATP13TP2"
                     /note="synonym: MGC52117"
                     /db_xref="GeneID:220323"
     CDS             242..1063
                     /gene="NS5ATP13TP2"
                     /codon_start=1
                     /product="NS5ATP13TP2 protein"
                     /protein_id="NP_848602.1"
                     /db_xref="GI:30425438"
                     /db_xref="GeneID:220323"
                     /translation="MRLPGVPLARPALLLLLPLLAPLLGTGAPAELRVRVRLPDGQVT
                     EESLQADSDADSISLELRKPDGTLVSFTADFKKDVKVFRALILGELEKGQSQFQALCF
                     VTQLQHNEIIPSEAMAKLRQKNPRAVRQAEEVRGLEHLHMDVAVNFSQGALLSPHLHN
                     VCAEAVDAIYTRQEDVRFWLEQGVDSSVFEALPKASEQAELPRCRQVGDHGKPCVCRY
                     GLSLAWYPCMLKYCHSRDRPTPYKCGIRSCQKSYSFDFYVPQRQLCLWDEDPYPG"
ORIGIN      
        1 cccggggccg cggagccggg ccggggcagc gccgtctccg cctcggggcc gccgggggcg
       61 ccctgctgag cgctacccac gtgcgtccgc gccacctcgc gggcgacccc gcggccaagg
      121 cccccggcgg agcggctccc gggcgccccg aactagcccc caactttggg cgaagtttgc
      181 ctgcgcctct ccccgccccc acgcggcgcg ccggggccgc ggacggcagc ggcccccggg
      241 gatgcgcctt cccggggtac ccctggcgcg ccctgcgctg ctgctgctgc tgccgctgct
      301 cgcgccgctg ctgggaacgg gtgcgccggc cgagctgcgg gtccgcgtgc ggctgccgga
      361 cggccaggtg accgaggaga gcctgcaggc ggacagcgac gcggacagca tcagcctcga
      421 gctgcgcaag cccgacggca ccctcgtctc cttcaccgcc gacttcaaga aggatgtgaa
      481 ggtcttccgg gccctgatcc tgggggagct ggagaagggg cagagtcagt tccaggccct
      541 ctgctttgtc acccagctgc agcacaatga gatcatcccc agtgaggcca tggccaagct
      601 ccggcagaaa aatccccggg cagtgcggca ggcggaggag gttcggggtc tggagcatct
      661 gcacatggat gtcgctgtca acttcagcca gggggccctg ctgagccccc atctccacaa
      721 cgtgtgtgcc gaggccgtgg atgccatcta cacccgccag gaggatgtcc ggttctggct
      781 ggagcaaggt gtggacagtt ctgtgttcga ggctctgccc aaggcctcag agcaggcgga
      841 gctgcctcgc tgcaggcagg tgggggacca cgggaagccc tgcgtctgcc gctatggcct
      901 gagcctggcc tggtacccct gcatgctcaa gtactgccac agccgcgacc ggcccacgcc
      961 ctacaagtgt ggcatccgca gctgccagaa gagctacagc ttcgacttct acgtgcccca
     1021 gaggcagctg tgtctctggg atgaggatcc ctacccaggc tagggtggga gcaacctggc
     1081 gggtggctgc tctgggccca ctgctcttca ccagccacta gagggggtgg caacccccac
     1141 ctgaggcctt atttccctcc ctccccactc ccctggccct agagcctggg cccctctggc
     1201 cccatctcac atgactgtga agggggtgtg gcatggcagg gggtctcatg aaggcacccc
     1261 cattcccacc ctgtgccttc cttgcgggca gagagggaga gaagggctcc ccagatctac
     1321 acccctccct cctgcatctc ccctggagtg ttcacttgca agctgccaaa acatgatggc
     1381 ctctggttgt tctgttgaac tccttgaacg tttagaccct aaaaggagtc tatacctgga
     1441 cacccacctc cccagacaca actcccttcc ccatgcacac atctggaagg agctggcccc
     1501 tcagtccctt cctactcccc aacaaggggc tcactatccc caaagaagga gctgttgggg
     1561 acccacgacg cagcccctgt actggattac agcatattct catctctggc cccgaggctg
     1621 cctgtggggc gagtggagac ctcccatcac tgagacagat cacagaccac gagtgccttt
     1681 cccggacctg gacgttgcct ccagagcagg caccagctct ttccctctct acacagaaat
     1741 atttttgtaa ggttctgggg cagggaggga gcatgaagta cgaggaaaac ttgaattcca
     1801 gatttttagt gcaaagtatt tatcatttct accagaaata aacgttttaa gtttttactt
     1861 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//

LOCUS       XM_044461               6743 bp    mRNA    linear   PRI 19-AUG-2004
DEFINITION  PREDICTED: Homo sapiens KIAA1102 protein (KIAA1102), mRNA.
ACCESSION   XM_044461
VERSION     XM_044461.12  GI:51464454
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_006238) using gene prediction method: GNOMON, supported by mRNA
            and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
             
            On Aug 19, 2004 this sequence version replaced gi:42657077.
FEATURES             Location/Qualifiers
     source          1..6743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..6743
                     /gene="KIAA1102"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON. Supporting evidence
                     includes similarity to: 2 mRNAs"
                     /db_xref="GeneID:22998"
     CDS             55..4935
                     /gene="KIAA1102"
                     /codon_start=1
                     /product="KIAA1102 protein"
                     /protein_id="XP_044461.10"
                     /db_xref="GI:51464455"
                     /db_xref="GeneID:22998"
                     /translation="MACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDF
                     RTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDP
                     SDLQDTSNRVTVKSLDYSRKLKNVLVTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQM
                     RKDTDDIESPKRSIRDSGYIDCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSP
                     DVVLRGSSDGRGSDSESDLPHRKLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQ
                     TAYVPAPLRKKKAEREEYRKSWSTATSPLGGERPFSFPETIEEEGSEVGSAGEDNPAG
                     QMNPGWKPSDGGCELPDGSGKEHPSSDGAVVAPAPKSEEKDAAEIQKRKRLEQAGIKV
                     MPAAQRFASQKQLSEEKEAIRDIVLRKENSFLTHQHGNDSEAEGEVVCRLPDLEKDDF
                     AARRARMNQTKPMVPLNQLLYGPYPKKGAEKSDGSKQLSKGISKKRSLEYKRNQGHTE
                     EVKLIVTCNMRAQESEPVEGGLRKVPDLHKDDLAQQRIQGSLAPHREPPSFITLSNIT
                     EADLETWERLKVSEKARDGDVQHICASEPSPEIKAETAIRDDFANRKARASKKASSPR
                     QKFVHFGPVTELDQQKWKRLSIGKAGPREDEEEVICHGSKIQMDSVSPVSAATSSLKG
                     HQIFNRQNDCRTMNCGRGDYCRRASWLAPVPESQEEWVCSLGECPRGTEEVTSKQLPQ
                     DGKEETESAPRDSERLSKAERSEDSSQPLVCPLASECEASGTEEKLEKMTAPAWSGSG
                     LKGQRKLDDSRKDDMMARRTGMSLRHTGSNPNQFLPVPFAKQQDVEESSKGLPMKDQR
                     YGPRTPVSDDAESTSMFDMRCEEEAAVQPHSRARQEQLQLINNQLREEDDKWQDDLAR
                     WKSRRRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYREIVQEKERRERELHE
                     AYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFLNDPNPM
                     KYLRQQSLPPPKFTATVETTIARASVLDTSMSAGSGSPSKTVTPKAVPMLTPKPYSQP
                     KNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSP
                     LELKQDNGSIEINIKKPNSVPQELAATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQ
                     HFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKS
                     PEPEATLTFPFLDKMPEANQLHLPNLNSQVDSPSSEKSPVMTPFKFWAWDPEEERRRQ
                     EKWQQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVS
                     SSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRL
                     EEKGSLTEGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTH
                     SSEDVKPKTLPLDKSINHQIESPSERRKKSPREHFQAGPFSPCSPTPPGQSPNRSISG
                     KKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNC
                     NDCYMRSRSAGQPTTL"
     misc_feature    139..468
                     /gene="KIAA1102"
                     /note="CH; Region: Calponin homology (CH) domain. The CH
                     domain is found in both cytoskeletal proteins and signal
                     transduction proteins. The CH domain is involved in actin
                     binding in some members of the family. However in
                     calponins there is evidence that the CH domain is not
                     involved in its actin binding activity. Most proteins have
                     two copies of the CH domain, however some proteins such as
                     calponin have a single copy only"
                     /db_xref="CDD:pfam00307"
     misc_feature    139..468
                     /gene="KIAA1102"
                     /note="CH; Region: Calponin homology domain"
                     /db_xref="CDD:cd00014"
     misc_feature    139..396
                     /gene="KIAA1102"
                     /note="IQG1; Region: Protein involved in regulation of
                     cellular morphogenesis/cytokinesis [Cell division and
                     chromosome partitioning / Signal transduction mechanisms]"
                     /db_xref="CDD:COG5261"
     misc_feature    139..375
                     /gene="KIAA1102"
                     /note="CH; Region: Calponin homology domain"
                     /db_xref="CDD:smart00033"
     misc_feature    142..498
                     /gene="KIAA1102"
                     /note="SCP1; Region: Calponin [Cytoskeleton]"
                     /db_xref="CDD:COG5199"
     misc_feature    4720..4911
                     /gene="KIAA1102"
                     /note="LIM; Region: LIM domain. This family represents two
                     copies of the LIM structural domain"
                     /db_xref="CDD:pfam00412"
     misc_feature    4720..4893
                     /gene="KIAA1102"
                     /note="LIM; Region: Zinc-binding domain present in Lin-11,
                     Isl-1, Mec-3. Zinc-binding domain family. Some LIM domains
                     bind protein partners via tyrosine-containing motifs. LIM
                     domains are found in many key regulators of developmental
                     pathways"
                     /db_xref="CDD:smart00132"
ORIGIN      
        1 cgacggcggc ggccgtcctc atcccggcgc ttgagaggac gcggggctgc gcaaatggct
       61 tgtcccgctc tcggtctgga agctcttcag cccctgcagc ccgagccgcc ccccgagccc
      121 gccttctccg aggcgcagaa gtggattgag caagtaactg gcagaagttt tggtgataaa
      181 gattttcgga caggtttaga aaatggaatc ctcctctgcg agttgctgaa tgctataaag
      241 ccaggacttg ttaaaaagat caatagattg cctaccccca ttgcaggact ggacaatatt
      301 atcttattct tgagaggttg taaagagctc ggccttaaag aatctcaact ttttgacccg
      361 agtgacctcc aggatacatc caacagagta acagtcaaga gccttgatta tagtaggaag
      421 ctgaaaaatg tattagttac catttactgg ctgggaaaag cagcaaacag ctgcacatcc
      481 tacagcggaa cgacactaaa cctgaaggag tttgaaggat tgttggctca gatgcgaaag
      541 gacactgatg acattgaaag tcctaaacgc agtatccgag acagtggcta catcgactgc
      601 tgggattccg agcgcagcga ctccctctct cctcctcgcc acggcagaga tgattccttc
      661 gacagcctgg attcctttgg ctctcgctct cggcagacgc cttcaccaga tgtagtcctc
      721 aggggaagca gcgatgggag aggaagcgac tctgaatccg acttgcctca tcggaagctg
      781 ccagatgtga agaaggatga catgtctgca cggcggactt cccatggtga gccgaaatca
      841 gcagtgcctt ttaaccagta cctcccgaac aaaagcaatc agacggccta cgtccccgcg
      901 cctctgagaa agaagaaagc agagagagag gaataccgca agagctggag taccgccacc
      961 tccccgctgg gtggggagag gcccttcagc tttcctgaaa cgatagagga agaggggagt
     1021 gaagtggggt ctgctggtga agacaaccca gctggccaaa tgaatcctgg ttggaagcct
     1081 tccgatggtg ggtgtgaatt acctgacggc agtggtaagg agcacccttc ttcagacggg
     1141 gctgtggtgg caccagctcc caagtctgaa gaaaaagatg ctgctgagat ccaaaagcgc
     1201 aaaaggctag agcaagctgg aatcaaggtc atgccagcag cacagcgctt tgccagtcaa
     1261 aaacaattaa gtgaagagaa agaagctatt cgtgatattg tccttcgcaa agaaaactct
     1321 ttcctgaccc accaacatgg caacgattca gaggcagaag gtgaagttgt gtgtcgactg
     1381 cctgatcttg agaaggatga ctttgctgca aggagagcaa ggatgaacca aaccaagcca
     1441 atggtgccat taaatcaact cctctatggc ccttatccaa agaaaggggc agagaaatca
     1501 gatggcagca aacagctctc aaagggaatc tcaaaaaaaa gaagtctaga atataaaaga
     1561 aaccagggcc acacagaaga ggtgaagttg atagtgacct gtaacatgag ggctcaggaa
     1621 agtgaacctg tggaaggagg actcaggaag gtgccagatc ttcacaagga tgacctggcc
     1681 cagcagagaa ttcagggcag ccttgcccct caccgcgagc ccccgagctt cattacgctc
     1741 tccaacataa cagaagctga cttggagacg tgggagagac tcaaagtgtc agaaaaggcg
     1801 agggatggag atgttcagca catctgtgct tctgagcctt ccccagaaat taaagcagaa
     1861 actgccattc gtgatgactt tgccaaccgc aaagcaaggg cctctaagaa agcttccagc
     1921 cccaggcaaa agtttgtgca ctttgggcca gtgacggagc tagatcagca gaaatggaag
     1981 cggcttagca ttggcaaggc tgggcctaga gaggatgaag aagaagtcat ctgtcatggc
     2041 agcaagattc aaatggactc tgtgtctcct gtctcagcgg ccacttccag cttaaagggc
     2101 caccaaatat ttaatcgaca aaatgactgc agaacaatga attgtggccg aggtgactat
     2161 tgcagaaggg cctcgtggct ggctcctgtg ccggagtctc aggaagagtg ggtctgcagt
     2221 ttgggcgagt gcccgagggg gacagaggaa gttacatcca aacagctgcc acaggatggc
     2281 aaagaagaaa cagaaagcgc tccaagagat tctgagaggc tgtcaaaggc agaaagatca
     2341 gaggacagca gccagccact ggtgtgtcct ctggcctctg agtgtgaggc ttcagggaca
     2401 gaagagaagt tggagaagat gacagctcct gcctggagtg gcagtggact gaaaggccag
     2461 cgaaagttgg atgattcacg aaaagatgac atgatggcca ggagaactgg gatgtccctt
     2521 agacacactg gatccaaccc aaaccagttc cttccagttc catttgcaaa gcaacaggat
     2581 gtggaagaat cttctaaagg tctacccatg aaagatcaga gatacggtcc gagaactcct
     2641 gtgtctgatg acgcagagag caccagcatg tttgacatgc ggtgtgagga ggaggccgcg
     2701 gtgcagccgc acagcagggc ccgccaggag cagctgcagc tgataaataa ccagctgagg
     2761 gaagaggacg acaaatggca agatgacctg gctcgttgga agagtcgtag aagaagtgtt
     2821 tctcaggact taatcaagaa agaggaagaa aggaaaaaaa tggagaagtt actggctgga
     2881 gaagatggga caagtgaacg aaggaaaagc atcaaaacct acagagaaat tgttcaagaa
     2941 aaagagcgga gagagagaga gctgcatgaa gcatataaga acgctcggtc ccaggaggag
     3001 gcagagggga tccttcaaca gtacattgag aggttcacca tcagtgaggc tgttctcgaa
     3061 cgcttggaga tgccaaaaat tctggaaaga agccattcaa cagagccaaa tttatcctcc
     3121 ttcctgaatg accccaatcc catgaaatac ctgcggcaac agtcactgcc tccacccaaa
     3181 ttcactgcca ctgttgaaac caccattgct cgtgccagtg ttctggatac cagcatgtca
     3241 gcaggcagtg ggtctccaag caaaactgtc actcccaaag cagtgcctat gctgacaccc
     3301 aagccttact cccagcccaa aaattctcaa gatgttctga agacctttaa ggtagacggg
     3361 aaagtcagtg tgaatggaga gacggttcat agagaggagg agaaggaaag agagtgtccc
     3421 acggtggcac ctgcccactc cttaaccaaa tcccagatgt ttgaaggtgt ggccagagtg
     3481 cacgggtctc cactggagct gaaacaagac aacggtagca tcgagatcaa cataaagaag
     3541 ccaaactctg ttccccaaga gctcgcagca accactgaga aaacggaacc gaatagtcaa
     3601 gaggacaaga atgatggtgg aaaatcaaga aaagggaata tagaacttgc ctcatcagaa
     3661 ccacagcatt ttacaacaac tgtgactcga tgcagcccga ccgtggcctt tgtggaattt
     3721 ccctccagcc cccagctgaa gaatgatgtg tcggaagaaa aagaccagaa gaaaccagaa
     3781 aatgaaatga gtggaaaggt ggagttggtg ctgtcacaaa aggtggtaaa gccaaaatct
     3841 ccagaacccg aagcaacgct gacatttcca tttctggaca aaatgcctga agccaaccaa
     3901 ctacatttgc caaatctcaa ttctcaagtg gattctccaa gcagtgagaa gtcacctgtt
     3961 atgacacctt ttaagttctg ggcatgggac ccagaagagg agcgcaggcg acaggaaaaa
     4021 tggcaacagg aacaggaacg tttgctccag gagagatacc agaaggagca ggacaagctg
     4081 aaagaagagt gggaaaaggc ccaaaaggag gtggaagagg aagaacgcag atactatgag
     4141 gaggagcgta agataattga agacactgtg gttccattta ctgtttcttc aagttccgct
     4201 gaccagctgt ctacctcttc ctccatgact gaaggcagtg ggacaatgaa taagatagac
     4261 ctgggaaact gtcaagatga aaaacaagac agaagatgga agaaatcatt ccagggagat
     4321 gacagtgact tattgctgaa gactagggaa agtgatcgac tggaggagaa gggcagccta
     4381 actgaagggg ccttggctca ttctgggaac cctgtatcaa aaggagtcca tgaagaccat
     4441 cagctggata ccgaggctgg ggccccacac tgtggaacaa acccacagct tgctcaggat
     4501 ccatcccaga atcagcagac atcaaatcca acgcacagtt cagaagatgt gaagccaaaa
     4561 accctcccgc tggataaaag cattaaccat cagatcgagt ctcccagtga aaggcggaag
     4621 aaaagtcccc gagagcactt ccaggctggg cctttctctc cctgttctcc cacccctccc
     4681 ggtcagtcac caaacaggtc tataagtgga aagaagctgt gctcttcctg tgggcttcct
     4741 ttgggtaaag gagctgcaat gatcatcgag accctcaatc tctattttca catccagtgt
     4801 ttcaggtgtg gaatttgtaa aggccagctt ggagatgcag tgagtgggac ggatgttagg
     4861 attcgaaatg gtctcctgaa ctgtaatgat tgctacatgc gatccagaag tgccgggcag
     4921 cctacaacat tgtgacacgg ctttcaagct tccggatcac tcaccatttc tttactgaga
     4981 gtgtcccctg gcaactgctt aacaaaatcc caagctcagg ggcttctcag catttaccta
     5041 atttctgaaa ggctcttctg aaaggtggta tctgttcttt cgtagcacag tgtttatgtt
     5101 tttcctgttt attgttttgg tttttttttt ttttttgcat ttgcacagta tacacaaaag
     5161 aatatggggt tgtaatgatc ctgaatagct caaaaaaggt tttagcatgg tcaaacaggc
     5221 ttatggttta aaatgtgtta ttctcttctt tgggaattag ctaaatgatg caataaacct
     5281 gttttgtttt agaatgtcta ggaattaaac actttatgtt tacagaattg agctgcagaa
     5341 agtgcaagac atgccaattt gagacacacg gtcttctaag actgaaggat aaatttaatg
     5401 catttcagaa actaaacatc acagcaagct ctatctctga gctataattt gtttttaatg
     5461 caaagacact agtttgataa tatatactgt aatcctgaaa catttgtgtt acttaccttt
     5521 ggaggtagaa attataccaa taaattattg caccgttagt attagattct gtgtaccttg
     5581 gaagttatgt cattaatata ggctggttca tcaaataaag caaaaccttg caatatcagc
     5641 tagatttaca ctccgggacg ttgcccaaag gtaggaagaa agcagaggga aatatttcag
     5701 tcatcatttc caaagtcatt atcaaaatct gtgaggaagt ttaatcttcc aaagagtcaa
     5761 tgtcagacat caggcctctg ttgcctgctt ctctcgaggc actagattag gagtcttcaa
     5821 taagagactt aacatgaggt atatggaaga tgaggcaccg agataagttc atcattaggt
     5881 gtgagcactg ctcacccttg ctggcaagtt ctccttaagg gcctgaagca caggtgtcca
     5941 aagaaaagcg ttaagtccat cttaatagaa tctatgtggt atatgatgtg gtcagcccct
     6001 ggtctgtgat cagcaagaac ctacagcaca gattatgccc tgcccacttc aatgaatacc
     6061 tactctcctc cattctccat cacttttttt gctatcaaga actccggacc ttgcccatgg
     6121 agaagtttag agaggaactc ttgtggagag ctggtttatt ttctgccctg tgcgacgagt
     6181 ttcagctggc caagaaagga gtcaagttat taaaaagcat cacaatgtag atctccaggc
     6241 tggttttttg ttttttgttg ttaagactgg ggaaaggggg actatttatt ctgccttaaa
     6301 tcaatggcaa ataagtcaag atgacatttt gtgaatgtag actatggata cactcctaat
     6361 agattgatgt agtcataaaa gggggtcaag tagatgtttt tctgttatgt aagcaataat
     6421 ttttccgtgt cttattgagt atggctagcg attatttatt acatgctaga tgggttcttt
     6481 gcatgtgggt tccatatagg tgcagaaatt tcctcagcca ctggagggat ttcgaccata
     6541 tttgtcattt ggatgagctg ttattagatt gaaatctaca catcatttca ttaaaaattg
     6601 tgccttagaa aacgcaaagc tgttgcacat ggcgataaat tatggatgca gtacattgaa
     6661 gagagatgaa gtcacttcca agtttccaag acttctcatg gaggtgtttg ctgttttaca
     6721 ggaaaaaata aaaataaaaa aag
//

LOCUS       XM_045308               4426 bp    mRNA    linear   PRI 20-AUG-2004
DEFINITION  PREDICTED: Homo sapiens PHD finger protein 19 (PHF19), mRNA.
ACCESSION   XM_045308
VERSION     XM_045308.8  GI:51467609
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_008470) using gene prediction method: GNOMON, supported by mRNA
            evidence.
            Also see:
                Documentation of NCBI's Annotation Process
             
            [WARNING] On Jan 31, 2005 this sequence was replaced by a newer
            version gi:58331160.
            On Aug 20, 2004 this sequence version replaced gi:41222695.
FEATURES             Location/Qualifiers
     source          1..4426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..4426
                     /gene="PHF19"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON. Supporting evidence
                     includes similarity to: 1 mRNA"
                     /db_xref="GeneID:26147"
     CDS             1..2178
                     /gene="PHF19"
                     /codon_start=1
                     /product="PHD finger protein 19"
                     /protein_id="XP_045308.4"
                     /db_xref="GI:51467610"
                     /db_xref="GeneID:26147"
                     /translation="MPIAEATCFVHCGGASPPDASYVPCTMLVLVIRGPYPSAQCKVL
                     CGLFGRPGSVSAPRVRAALLCVCARVRRCLRAELCFLNKCASGRVRHERCLASPCAPR
                     CGRSSAGGPGPGYQRPPWERPRRMNHPRFLPPPGPALPCQGKLMENRALDPGTRDSYG
                     ATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVT
                     FEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPI
                     AGSADQPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPH
                     RTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCN
                     QGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTP
                     VTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPNENS
                     ASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLAS
                     IFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAA
                     KAYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKS
                     SITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY"
     misc_feature    547..696
                     /gene="PHF19"
                     /note="TUDOR; Region: Tudor domain"
                     /db_xref="CDD:smart00333"
     misc_feature    676..888
                     /gene="PHF19"
                     /note="COG5141; Region: PHD zinc finger-containing protein
                     [General function prediction only]"
                     /db_xref="CDD:COG5141"
ORIGIN      
        1 atgccaattg cagaagccac ttgctttgtc cactgtgggg gtgccagtcc tccggatgcc
       61 tcctacgtgc cctgcactat gctggtcttg gtaatccgtg gtccctatcc cagcgcccag
      121 tgcaaggtgt tgtgtggcct gtttgggcgt cctgggtctg tgtctgcgcc aagggtccgc
      181 gccgccctgc tgtgtgtctg tgccagggtc cgccggtgcc tgcgcgcaga gctgtgtttc
      241 ctcaacaagt gtgcgagcgg tcgtgtgcgc catgagcgct gcctggcgtc tccgtgtgcg
      301 ccgcggtgtg gccgctcctc ggcggggggc ccgggtcctg gctaccaacg gccgccctgg
      361 gagaggcccc ggcgcatgaa tcatcctcgc ttcctgcccc cgcccggccc cgcgctcccg
      421 tgtcagggga agctgatgga gaatcgagct ctggatccag ggactcggga ctcctatggt
      481 gccaccagcc acctccccaa caagggggcc ctggcgaagg tcaagaacaa cttcaaagac
      541 ttgatgtcca aactgacgga gggccagtat gtgctgtgcc ggtggacaga tggcctgtac
      601 tacctcggga agatcaagag ggtcagcagc tctaagcaaa gctgcctcgt gactttcgaa
      661 gataattcca aatactgggt cctatggaag gacatacagc atgccggtgt tccaggagag
      721 gagcccaagt gcaacatctg cctagggaag acatcagggc cgctgaatga gatcctcatc
      781 tgcgggaagt gtggcctggg ttaccaccag cagtgccaca tccccatagc gggcagtgct
      841 gaccagcccc tgctcacacc ttggttctgc cgacgctgca tcttcgcact ggctgtgcgg
      901 aaaggcggcg cgctgaagaa gggcgccatc gccaggacgc tgcaggccgt gaagatggtg
      961 ctgtcctacc agcccgagga gctcgagtgg gactcgcccc atcgcaccaa ccagcagcaa
     1021 tgctactgct actgcggcgg gcccggagaa tggtacctgc ggatgctgca atgttaccgg
     1081 tgcaggcagt ggttccacga ggcctgcacc cagtgcctca atgagcccat gatgtttgga
     1141 gaccggtttt acctgttctt ctgctccgtg tgtaaccagg gcccagagta catcgagagg
     1201 ctgcccctgc gatgggtgga tgtggttcac ctggccctct ataatctggg ggtacagagc
     1261 aagaagaagt actttgactt tgaggagatt ctggcctttg tcaaccacca ctgggagctc
     1321 ctgcagcttg gcaagctcac cagcacccca gtgacagatc gaggaccaca tctcctcaac
     1381 gctctgaaca gttataaaag ccggttcctc tgcggcaagg agatcaagaa gaagaagtgc
     1441 atcttccgcc tgcgcatccg cgtcccaccc aacccgccag ggaagctgct gcctgacaaa
     1501 ggactgctgc caaatgagaa cagcgcctcc tctgagctgc gtaagagagg aaagagcaag
     1561 cctggtttgt tgcctcacga attccagcag cagaaaaggc gagtttatag aagaaaaaga
     1621 tcaaagtttt tgctggaaga tgctattccc agtagtgact tcacctcagc ctggagcacc
     1681 aaccaccacc tggctagcat atttgacttc acgctggatg aaattcaaag tttaaaaagt
     1741 gccagctcag gccagacctt cttctcagat gtcgactcca ccgacgctgc cagcacctct
     1801 ggctctgcct ccaccagcct ctcctatgac tccagatgga cagtgggcag ccgaaagagg
     1861 aagctggcag ccaaggcata catgcccctg cgggcaaagc ggtgggcagc tgagctggat
     1921 ggacgctgcc cctcggacag cagtgcagag ggggcttcag tccccgagcg gccagacgaa
     1981 ggcattgaca gccacacatt tgagagcatc agtgaagatg actcatccct gtcccacctc
     2041 aagtcatcta tcaccaacta ctttggtgca gctgggcggt tggcctgtgg ggagaagtac
     2101 caggtgttgg ctcggagggt cacacctgag ggcaaggttc agtacctggt ggagtgggaa
     2161 gggaccaccc cttactgact agcccccggg ggtgccaggg gtcctgaaaa ccaaaggagg
     2221 agcagcagaa gccataggct ccccagcttt ctccaggctg gggtgggaga aggaagcagg
     2281 acagagctgc aagtgcctgg cagaatgccc tgcctgcctg cctgccaggc caaggcctgc
     2341 gtctctctgc tgtaccagct ctgttccagg gcctcctcag gctcgttacc cctgtgcctg
     2401 tgtctctaca cactccacac cccctcaaac tctgtttatc tgttctctga ccttgtgtcc
     2461 cctgcgctgg gacccttcct cctgaggccc aggtctttgt ccccagttgt gtgccttgac
     2521 ctctctcgcc cctttctggg tgtgttcgca catcctgtgt gtgcacagct gtccctccac
     2581 tggatcccct tcacacgtga cccgtggggc agccagtcct cccagggact acataacagg
     2641 cacctttgag agagcatggg agaaggtgga taagaggatg ctgctcagtg cttttctctt
     2701 ccactttcct gccactcccc actaccctcg gagagaggtg gtgggatggg agagagcccc
     2761 tgtgaaagcc tgtgaggatc tgaagagtaa agggctgggt ctgcctcaga aggcaccagc
     2821 accagggccc aggtattaag gctgagagtg aaggctgcca atgtcagctt tggaggtccc
     2881 agaagtcttc tgttctctgg cctcaccccc tcagtcgcca tagagctggg cctggccttg
     2941 ctggaatgga ggcatccttc caaacctggg ggacgggggt ggggggtggt agtggtggga
     3001 gggaaaccat gtcttgctaa acctgtttct ggtgcctccc atccccagac ccaccagaca
     3061 ccacacagca gacaatacac acccactcgc acaagcttcc atccacatgt gttgtacttt
     3121 cagctctagg catgcagaca accccacacg gccacaccac cacatgccca agtgtacaca
     3181 cacagagcca caccgtccct ctgggcctgc tggctcctcc cttggctttc ccttggccca
     3241 cttccagggc ccaggtgctg caactaaatg tgaaagctca gtggccgctc cttctttcag
     3301 cccatcaacc agcattggtc ccatagggaa gcacagggga ctcaccctct ttcatatccc
     3361 ttgccctgcc ctgaaatgga caatcacttt ttgggatagg ttgaaatttt taaagagcct
     3421 gcatcatttg gttccctcaa agggaagccc ttgccagtgg gggtttgaaa gagaattttt
     3481 ggaaccaaca ttcaaattct gcctcatctg gagggaaacc aaaattggga gggggaagag
     3541 gacccctgat gttttgctgc ttccagagat attagaaact gactcacttg attggaaaat
     3601 ggacaaaagt gccttgacgt ggagggtggg caccagatgg ggaccagcct tgccaactgc
     3661 tgctgtggcc tccagcttgg ctggttttgc aggccgccag caggaaggcg aaggtggtag
     3721 tacagcaaga ggcactggcg gggcagcagg cctgcaggag ctgtttttcc attgctaggc
     3781 ctgacccctc tctacctgtg agcgttcagg gggtccctga gatagtttag atgccccccc
     3841 atcttagacc tcagctccca cagtgccttt taagggggac ctcacctcct gtgcacagcc
     3901 cacccacttt cctctgcttc cctggcacag cccaggcata gacgagctgg cgttggaccc
     3961 agttcttccc ccttttcagc cccacagctg ctgccacagg ggccaactag ggccaggtgg
     4021 aaggggagct gagaagccaa cccctagccc aggggtgctg tgggaactgg gatccaattt
     4081 gtagcttcct gcctggcttc agagagccca gcaaccttct aggcctgctt tccagacttc
     4141 tgagatagcc tgggatgagc aatcctgtta tagtacatct ggaccttccc tacctgggct
     4201 ctggggaggc tgtgggcctg gagagggaaa aggagggagg gggtgtctgc accacctggg
     4261 aagatagcac aaggcctaat gaggtcaccc tgactcccca ccccagcatt tcattcatac
     4321 cagataatag ctgcattact gccaactgac cttataaccc tctgcacctt caaaaagatt
     4381 catggttttt aattgctgct tttaataaca tttgttaaag ttataa
//

LOCUS       XM_209892               3540 bp    mRNA    linear   PRI 17-OCT-2003
DEFINITION  Homo sapiens similar to hypothetical protein FLJ20200 (LOC286077),
            mRNA.
ACCESSION   XM_209892
VERSION     XM_209892.4  GI:37552413
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_023684) using gene prediction method: GNOMON, supported by EST
            evidence.
            Also see:
                Documentation of NCBI's Annotation Process
             
            On Oct 7, 2003 this sequence version replaced gi:30150500.
FEATURES             Location/Qualifiers
     source          1..3540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..3540
                     /gene="LOC286077"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON."
                     /db_xref="GeneID:286077"
                     /db_xref="InterimID:286077"
     CDS             1..3540
                     /gene="LOC286077"
                     /codon_start=1
                     /product="similar to hypothetical protein FLJ20200"
                     /protein_id="XP_209892.2"
                     /db_xref="GI:37552414"
                     /db_xref="GeneID:286077"
                     /db_xref="InterimID:286077"
                     /translation="MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGSEAYS
                     RFLATEGAPDFLCPEELEHVSRHLRPPQYVTREPPEGSLLDVDMDGSSGTYWPVNSDQ
                     AVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTD
                     VDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLQHVDFLRVRTVAGPTYYC
                     RTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRI
                     LFAQSEPLVPSAAALARMDAYALAPYAGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPR
                     EEGLGFPSFLDPDRHFLSAFRREEPPRMPGGALEPHAGLRPLSRRLEAEAGPAGELAG
                     ARGFFQARHLEMDAFKRHSFATEGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFHR
                     DQLYQQQYQWDPQLTPARPQGLFEKLRGGRAGFADPDDFTLGAGPRFPELGPDGHQRL
                     DYVPSSASREVRHGSDPAFAPGPRGLEPSGAPRPNLTQRFPCQAAARPGPDPAPEAEP
                     ERRGGPEGRAGLRRWRLASYLSGCHGEDGGDDGLPAPMEAEAYEDDVLAPGGRAPAGD
                     LLPSAFRVPAAFPTKVPVPGPGSGGNGPEREGPEEPGLAKQDSFRSRLNPLVQRSSRL
                     RSSLIFSTSQAEGAAGAAAATEKVQLLHKEQTVSETLGPGGEAVRSAASTKVAELLEK
                     YKGPARDPGGGAGAITVASHSKAVVSQAWREEVAAPGAVGGERRSLESCLLDLRDSFA
                     QQLHQEAERQPGAASLTAAQLLDTLGRSGSDRLPSRFLSAQSHSTSPQGLDSPLPLEG
                     SGAHQVLHNESKGSPTSAYPERKGSPTPGFSTRRGSPTTGFIEQKGSPTSAYPERRGS
                     PVPPVPERRSSPVPPVPERRGSLTLTISGESPKAGPAEEGPSGPMEVLRKGSLRLRQL
                     LSPKGERRMEDEGGFPVPQENGQPESPRRLSLGQGDSTEAATEERGPRARLSSATANA
                     LYSSNLRDDTKAILEQISAHGQKHRAVPAPSPGPTHNSPELGRPPAAGVLAPDMSDKD
                     KCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEAS
                     SPGAGEGPAEEGTRDSKVGKFVPKILGTFKSKK"
ORIGIN      
        1 atggcccgtc gctctcagag ctcctcgcag ggggacaacc cactggcacc cgggtacctg
       61 ccgcctcact acaaagagta ctaccgcctg gcggtggatg cactggccga gggtggctcg
      121 gaggcctaca gccgcttcct cgctaccgag ggggcaccag acttcctgtg ccctgaagag
      181 ctggaacatg tgagccgaca ccttcggcct ccgcagtatg ttacccgaga gccacctgaa
      241 ggcagccttc tcgacgtgga catggatggc tcctcgggta catactggcc agtgaactca
      301 gaccaggccg tgcctgagct tgatttgggc tggcctctga ccttcggctt ccagggcacc
      361 gaggtgacca ccttggtgca gccaccgccc cccgacagcc ccagtatcaa ggatgaggcc
      421 cgcaggatga tccgttccgc ccagcaggtg gtggccgtgg tgatggacat gttcactgat
      481 gtggacctgc tcagcgaagt gctggaggcc gcggcccgtc gggtcccagt ctacatcctg
      541 ctggatgaga tgaacgcgca gcacttcctg gacatggccg acaagtgccg tgtcaacctg
      601 cagcacgtgg atttcctgcg cgtacggact gtggcgggcc ccacctacta ctgccgcact
      661 gggaagtcct tcaagggcca cgtcaaggag aagttcctgc tggtggactg tgccgtggtg
      721 atgagtggga gctacagctt catgtggtcc tttgagaaga tccaccgcag cctggcgcac
      781 gtgttccaag gagagctggt ctccagcttc gacgaggagt tccgcatcct cttcgcgcag
      841 tccgagccgc ttgtgccctc ggccgcggcc ctggcccgca tggacgccta tgccctggct
      901 ccgtatgccg gggccgggcc tctcgtgggc gtccctgggg tcggggcgcc aacccccttc
      961 tccttcccta aacgagcgca cctcctgttc ccgccacccc gggaagaggg cctgggcttc
     1021 ccctccttcc tcgacccgga ccgccacttc ctgtcggcct tccgccggga ggagccgccg
     1081 cggatgccgg ggggcgcgct ggaaccgcac gcggggctgc ggccgctctc gcggcgcctg
     1141 gaggccgagg ccgggccggc tggggagctc gcgggcgcgc ggggcttctt ccaggcgcgg
     1201 cacctggaga tggacgcctt caagcggcac agcttcgcga ccgagggcgc gggcgccgtg
     1261 gagaacttcg cggccgcgcg gcaggtgtcg cggcagacgt tcctcagcca cggcgacgac
     1321 ttccgcttcc agaccagcca cttccaccgt gaccagctct accagcagca gtaccagtgg
     1381 gacccgcagc tcacgccggc gcgcccgcaa ggcctgttcg agaagcttcg cgggggccgc
     1441 gcgggtttcg cggacccgga tgacttcacc ctgggcgccg ggccccgctt cccggagctc
     1501 ggacccgacg ggcaccagcg gctggactac gtgccgtcca gcgcgtcccg cgaggtgcgc
     1561 cacggctcgg accccgcctt cgcgcccgga ccccgcggcc tggagcccag cggagccccg
     1621 cgccccaacc tgacccagcg cttcccatgc caggccgcgg cgaggccggg cccagacccc
     1681 gctcccgagg cggagccgga gcgcaggggc gggcccgagg ggcgggcagg gctgcggcgc
     1741 tggcgtttgg cctcctactt gagcggctgc cacggcgagg atgggggcga cgacggccta
     1801 ccggcgccca tggaagcgga ggcttacgaa gacgacgtgc tggctcccgg gggccgggca
     1861 cctgccggcg acctgctccc ctcggccttc cgcgtcccag cagccttccc caccaaggtc
     1921 ccggtgccag gcccgggcag cggcggcaac ggcccagagc gcgagggccc ggaggagcct
     1981 ggcctggcca agcaggactc attccgctcg cgcctgaacc ccctggtcca gcgcagctcc
     2041 aggctgcgct cctcgctcat cttcagcacg tcacaggccg agggcgcggc cggggctgcg
     2101 gcggccactg agaaggtgca gctgctgcac aaggagcaga cggtcagcga gacgctgggg
     2161 cccggcggag aggccgtgcg ctccgcggct tccaccaagg tggcggagct gctggagaag
     2221 tacaagggcc cagcccgtga tcccggcggc ggcgcgggcg ccatcaccgt tgccagccac
     2281 agcaaggccg tcgtgtccca ggcgtggcgg gaagaggtgg cggccccagg tgccgtgggg
     2341 ggcgagcgcc gcagcctcga gagctgcctg ctggacctgc gcgactcctt tgcacagcag
     2401 ctgcaccagg aggcggagcg gcagccggga gccgcgtcgc tcaccgcggc gcagctgctc
     2461 gacacactgg gccggagcgg ctccgaccgc ctgccttccc gcttcctctc tgcccagagc
     2521 cactcaacgt ccccgcaagg gctggacagc cctctgccgc tggaagggtc cggagcgcac
     2581 caggtgctcc ataatgagtc aaaagggagc cccacctcgg cttaccctga gcggaagggg
     2641 agccccacgc ctgggttttc cactcgaaga ggaagtccaa ctacaggatt tatcgagcag
     2701 aaggggagcc ccacctcagc ctaccccgag cgcaggggta gtccggtgcc ccccgtgccg
     2761 gagcgcagga gcagtccggt gccccccgtg ccggagcgca ggggcagcct cacccttacc
     2821 atctccgggg agtccccgaa ggccgggccc gcggaggagg ggccgagcgg ccccatggaa
     2881 gtcctgcgca aaggctcctt gcgtcttagg cagctgctga gccccaaggg cgagcggcgc
     2941 atggaggatg agggtggctt cccagtgccg caggagaacg gccaacccga gagcccgcgg
     3001 cgtctgtcac tgggccaggg tgacagcacg gaggctgcca cagaagagcg gggtccgcgg
     3061 gcgcgcctgt cctcagccac ggccaacgcc ttgtacagca gcaaccttcg ggatgacacg
     3121 aaggccattc tggagcagat cagtgcccac ggccagaagc accgtgcggt ccctgccccg
     3181 agccccggcc cgacccacaa cagccccgag ctaggccgtc caccggctgc tggcgtcctg
     3241 gccccagata tgtccgacaa ggacaagtgt tcagccatct tccgctcgga cagcttgggg
     3301 acccagggcc ggctgagccg cacgctgcca gccagcgcgg aggagcgcga tcggctgctg
     3361 cgccgcatgg agagcatgcg caaggagaag cgcgtgtaca gccgcttcga ggtcttctgc
     3421 aagaaagagg aggccagcag ccctggggca ggggaaggcc ccgcggagga gggcaccagg
     3481 gacagcaagg tgggcaagtt cgtgcccaag atcctgggca cgttcaaaag caagaagtga
//

LOCUS       XM_290546               4673 bp    mRNA    linear   PRI 20-AUG-2004
DEFINITION  PREDICTED: Homo sapiens KIAA0830 protein (KIAA0830), mRNA.
ACCESSION   XM_290546
VERSION     XM_290546.3  GI:51470759
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_008984) using gene prediction method: GNOMON, supported by mRNA
            and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
             
            On Aug 20, 2004 this sequence version replaced gi:41149629.
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..4673
                     /gene="KIAA0830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON. Supporting evidence
                     includes similarity to: 3 mRNAs"
                     /db_xref="GeneID:23052"
     CDS             107..1609
                     /gene="KIAA0830"
                     /codon_start=1
                     /product="KIAA0830 protein"
                     /protein_id="XP_290546.3"
                     /db_xref="GI:51470760"
                     /db_xref="GeneID:23052"
                     /translation="MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPP
                     AGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQID
                     DPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTL
                     TNSAPMTQSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEF
                     VWLAACCAVPGGGWAMGFVKHTRDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDT
                     EKMKKILEVVNQIQDEERMVQSQKSSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGF
                     IATPFIKLFQLIYYLVVAILKNIVYFLWCVTKQVINGIESCLYRLGSATISYFMAIGE
                     ELVSIPWKVLKVVAKVIRALLRILCCLLKAICRVLSIPVRVLVDVATFPVYTMGAIPI
                     VCKDIALGLGGTVSLLFDTAFGTLGGLFQVVFSVCKRIGYKVTFDNSGEL"
     misc_feature    296..817
                     /gene="KIAA0830"
                     /note="Endonuclease_NS; Region: DNA/RNA non-specific
                     endonuclease"
                     /db_xref="CDD:pfam01223"
     misc_feature    299..949
                     /gene="KIAA0830"
                     /note="NUC; Region: DNA/RNA non-specific endonuclease"
                     /db_xref="CDD:cd00091"
     misc_feature    299..802
                     /gene="KIAA0830"
                     /note="NUC; Region: DNA/RNA non-specific endonuclease"
                     /db_xref="CDD:smart00477"
     misc_feature    299..766
                     /gene="KIAA0830"
                     /note="NUC1; Region: DNA/RNA endonuclease G, NUC1
                     [Nucleotide transport and metabolism]"
                     /db_xref="CDD:COG1864"
ORIGIN      
        1 cccttcccta ccctgctcgg ctgcgtagtg cgctccccgc ccagcctgca gagctcgcgc
       61 cgcggcagcc cagccgctcg gccccgccgc gctcgcagag gccgccatgg gcaccgcgcg
      121 ctggctcgcg ctgggcagcc tcttcgccct ggctgggctg ctggaaggcc ggctcgtggg
      181 cgaggaggaa gccggctttg gcgaatgtga caagttcttc tacgccggga ccccgcctgc
      241 ggggctggcg gccgattccc acgtgaagat ctgtcagcgc gcggagggtg ctgagcgctt
      301 cgccaccctc tacagcaccc gggaccgcat ccccgtgtac tccgcgttcc gcgccccgcg
      361 ccctgcgccc ggcggcgccg agcagcgatg gctggtggag ccgcagatcg atgaccccaa
      421 cagcaacctt gaggaggcga ttaatgaggc agaggccatc acctctgtga acagcctggg
      481 aagcaagcaa gccttgaata cagattacct tgattctgat taccaaagag gacagcttta
      541 cccattctcc cttagcagtg atgtccaggt ggccacattt actctcacaa attcagcccc
      601 aatgactcag tccttccagg aacggtggta tgtgaatctc cacagcctaa tggaccgggc
      661 tttgacccca cagtgtggca gtggggaaga cctatatatc ctcacaggca cagtgccctc
      721 agactacaga gttaaagaca aagtggcagt ccctgagttt gtttggctgg cagcctgttg
      781 tgctgtccct ggaggaggct gggccatggg ctttgtcaag cacacccggg acagtgacat
      841 catagaagat gtgatggtaa aagatcttca gaaactgctt ccatttaacc ctcagctgtt
      901 tcagaacaac tgtggtgaaa ctgagcaaga cacagagaaa atgaaaaaaa tcctggaagt
      961 ggttaaccaa atccaggatg aagaacgaat ggtacaatct caaaagagtt ctagtcccct
     1021 ttctagcacc aggagcaaga ggtctactct gttgcctcca gaggcatctg agggaagtag
     1081 tagctttttg ggaaaactca tgggcttcat tgctacccca ttcatcaagc tttttcaatt
     1141 aatttattac cttgtggtag caatcctgaa gaacattgtc tatttcctgt ggtgtgttac
     1201 caagcaggtg attaatggca tagaaagttg cctttaccgc ctgggctcag ccaccatctc
     1261 atacttcatg gccattgggg aagagttggt gagcattccc tggaaggtgc tcaaggtcgt
     1321 ggccaaagtc atcagggctc tcctccggat cctttgttgt ctgctgaagg ccatttgccg
     1381 agttctgagc atccctgtcc gtgtccttgt ggatgtggcc actttccctg tgtacaccat
     1441 gggcgctatt ccaattgttt gcaaggacat tgcactgggc cttggtggca ctgtctcact
     1501 gctctttgac actgcttttg gtaccctggg tggcctattt caggtggttt ttagtgtctg
     1561 caagcggatt ggctacaagg ttacttttga caattctggg gagttataaa ctcaaaaaac
     1621 taatagtatc cagtcacagt gaatttgaaa gctggaatag tttgtcttta caatgggttt
     1681 ctgttcactg tcagttatca ttatattttg gcctttggtg gggatgtctg cttgtttttg
     1741 caaaagaaga tggcagaatt tagacttgac agaggagaaa tgctcagggt gagattaggt
     1801 gtagtaatct gctgtttacc tccagttata tgtgcaaact cccaagccac taataacttc
     1861 agttatgcac tctaacacag acgaccacct gaaatgcact ggtatttatt tctgataatt
     1921 aaaaattaca ggggagggaa gaactagaaa aagaacaact ttagaccaaa ggtgtctgag
     1981 aaaaggagaa agggagcttg ttcttcccat tgctctttgt gatttaaggc aaaacagatt
     2041 aaaaaaaaaa tctgcagcca atttcttggc atttgcttct ctttctcctc aactcgactg
     2101 accttggtgg aatgcagata atgcctcttt gttgaaataa ctttgtggga atgtacaatt
     2161 ttctatatct cttagctttc cgtggttctc aaggatatgt acagttttca ttttcctcca
     2221 aagttgaatt ttgctacatt tttcttttag gtaatgataa gcatttttta aaaaatcatt
     2281 tttaggtaat ggtaagcatt ttatgccaaa tgtggcataa cagagtttga attgaagggc
     2341 aaagttttct tttctttttt ttttgggccc cttgaatggt ataatacagt cctctccggt
     2401 ggaaagaaga gaagagaagg tggacagccc tgctcttagt aggtgctgca gatccaagga
     2461 catcttttgt ccagcttgga ttaacttgac gtgtatccct gcctgacaag gttgaactga
     2521 aagatctata tgttaagcta acatgaaaat tcatattctg caacatagta gatttttcta
     2581 atgcatgaaa taagtaccca gcacagtaaa aatactctga cttatgtccc taaatggttg
     2641 ttttgataca actatataga aaagagccac aaaataaaga taaaagttat tgtggccatc
     2701 tctgaaaaaa atatataaaa tatttaagaa taattatatc ttaggaaatt atttttacag
     2761 tgtgtttgag gctacaaaca taactccccc attaatacaa attaaatgtg agagctcatt
     2821 ctcaaaattt ttttgatcaa gcacttgtca ttttaaatct tgcactaaaa aatggtaaca
     2881 agagggacca aactttgctt cccacaattg ggatggaatc acctggattt ttctgaatgt
     2941 tttaaagaat tgctgagagg tagaaacagc caagtatgaa atactgatct tggggctacc
     3001 gcccaggatc aatcagaaag ttatatgcaa aaattcgggg tcccaacaag gagagaacaa
     3061 tatgtcaacc atttgcatgg ggtcgatgga tgagaaacat gagcgtagca agagttacat
     3121 tttgcagaaa aatagcggag gcacacccag agtagaacag cagccagcaa gctgccatcc
     3181 tgatcaattt gtgatgcaag gttagggagt atgagcaccg catgggtcca tgctagggag
     3241 atgtgcacca ggcttagcta agaaacttaa agcagtattt taccaactct tgtcttaggg
     3301 agcataaagt ttggatgtcc ctttatttca gcagtgtgaa ggtaaatgga agggtgaggg
     3361 tttgacttgg tactgattgg tcaagaatcc tgctggataa agaaaaggaa ttttagaagt
     3421 gaccagaggg acagtccagc caaactatta tttgataagg aacccaaggc cctgggaggc
     3481 aacaggctag cccttagttt catggctagc tgagagcaga ttaggagcca acgttgtttg
     3541 cacatgtccc atcacacctg agatgtcaga catgggaagt tcgtgctatt attcagttgc
     3601 ctctctggac catggcaaga tttcctcatt catcaaacag actccaggcc ctgacaaagc
     3661 agttggattt ggcatgtgtg atgaaaacaa ttagccatcc atgtacaaca ttatgcttac
     3721 tgcatcccat ggaaacttaa ttccctccta gcacatattt gcatactgaa aggtccgaaa
     3781 agggcatcca cggcagcttg agccccttag caccatgtaa ggagcacagc atccaaacgg
     3841 cttcttgaga accattgggg aatgtctttc tttttcacat ccaattgttt agtgtctatt
     3901 tattcttggg tggccagttt tgaaacctaa aaagggacaa taaagcaaaa agtatcagta
     3961 aggataggtg gctgagaccc actgccctga gctactagtg tggctgtgcc tgtgggtctc
     4021 tagaaccatc tgcattggac gtgaagccac agcaggtggc tggactgctg gcctgttcct
     4081 aatgagctac gctgggcttt gaggtagagg ttggggttta tgaaccccaa ctctggctta
     4141 aagatcttgc tgtggctctg ttatgttctg aggccttggg attagcctct tcctcattat
     4201 ggagctgatt ttctagtctg tggatcagct atgcctttgg acacttctct tttccattgt
     4261 gccttttgaa tgttgtcttc tcactcagca tcagcacttc gatctaaatg cagactaggt
     4321 agttgggagg aggaaccaaa gtgaaccatc cttcatttat tcagtcattc gttcatctgt
     4381 caaacacgta tttggacatc aaggttgcag agatgaacaa tgcatggatt tcatctttga
     4441 ggagttcaaa acctagtgga gagaacacat ggtacaatcg taacacatga aggacaagta
     4501 agtgctgcag taaaggtact aataacatgt tccttggaac agaggaagaa aaaccacgaa
     4561 accatggaaa ttagggaagc ctttacagag ggtgtgacaa aactcaattt gacattttca
     4621 agctatgtac aatgatgtgc accttgcaga tgctcaataa agtaattact gac
//

LOCUS       XM_291142               4915 bp    mRNA    linear   PRI 19-AUG-2004
DEFINITION  PREDICTED: Homo sapiens FCH domain only 2 (FCHO2), mRNA.
ACCESSION   XM_291142
VERSION     XM_291142.4  GI:42657379
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_006713) using gene prediction method: GNOMON, supported by mRNA
            and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
             
            [WARNING] On Feb 9, 2005 this sequence was replaced by a newer
            version gi:58743366.
            On Feb 19, 2004 this sequence version replaced gi:37550358.
FEATURES             Location/Qualifiers
     source          1..4915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..4915
                     /gene="FCHO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON. Supporting evidence
                     includes similarity to: 5 mRNAs"
                     /db_xref="GeneID:115548"
     CDS             51..2483
                     /gene="FCHO2"
                     /codon_start=1
                     /product="FCH domain only 2"
                     /protein_id="XP_291142.1"
                     /db_xref="GI:29736572"
                     /db_xref="GeneID:115548"
                     /translation="MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERAT
                     IEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQ
                     KYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQ
                     REIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIG
                     SLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDTA
                     SAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPETNQNDT
                     KENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSPAISR
                     HSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSAR
                     PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAES
                     SSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCI
                     VKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSN
                     TKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSAS
                     TTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSS
                     ISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIK
                     KRFATGRYLADC"
     misc_feature    75..320
                     /gene="FCHO2"
                     /note="FCH; Region: Fes/CIP4 homology domain. Alignment
                     extended from. Highly alpha-helical"
                     /db_xref="CDD:pfam00611"
     misc_feature    78..332
                     /gene="FCHO2"
                     /note="FCH; Region: Fes/CIP4 homology domain"
                     /db_xref="CDD:smart00055"
ORIGIN      
        1 acacagcggc gggcgggcgc ggacgcggaa cccggcgcgg cggcggcacg atggtcatgg
       61 cgtatttcgt cgagaatttt tggggggaaa aaaatagtgg ctttgatgtc ctctaccata
      121 atatgaaaca tggacagata tcaacaaaag aactagcaga ttttgtaagg gaacgagcta
      181 ccatagagga ggcatactcc aggtcaatga caaaactagc aaaatctgca agcaattatt
      241 cacaacttgg aacatttgca ccagtatggg atgtattcaa aacatctaca gagaaattag
      301 caaattgtca cttggatctt gttagaaaat tacaagaatt aataaaggaa gttcagaagt
      361 atggagaaga acaagtaaag tctcataaaa agactaaaga agaagttgca ggaactctgg
      421 aagctgtcca aaccattcag agcataactc aggccctcca gaaatccaag gaaaattaca
      481 atgccaagtg tgtagaacag gagcgtttga aaaaggaagg agctacacaa agagaaatag
      541 aaaaggcagc tgttaaatct aagaaagcta cagataccta taaactctat gtggaaaaat
      601 atgcattagc aaaagctgat ttcgaacaga aaatgacaga aacagctcag aaatttcaag
      661 atattgaaga aactcatctc attcacataa aggaaattat aggatccttg tcaaatgcta
      721 taaaggaaat tcatttgcag ataggccagg tccatgaaga atttataaat aacatggcta
      781 atactacagt tgaaagtttg atacaaaaat ttgctgagtc aaaaggcact gggaaggaaa
      841 gacctggcct cattgaattt gaagaatgtg acactgctag tgcagttgaa ggtataaaac
      901 caaggaaaag aaagaccttt gctttgccag gaatcattaa aaaggaaaaa gatgcagaat
      961 ctgtggaatg tcctgatgca gattcattga acattcctga tgtagatgaa gaaggctaca
     1021 gtattaaacc agaaacaaat cagaatgata ccaaagagaa ccatttctac tcatctagtg
     1081 attctgactc cgaagatgaa gaaccaaaga agtatcggat agaaattaag cctatgcatc
     1141 caaataactc acatcacaca atggcttctt tggatgaatt aaaagtatct atagggaata
     1201 taacactctc cccagcaata tctagacaca gtccagtaca gatgaatcgg aatttgtcta
     1261 atgaggagtt aacaaaatca aagccatctg ctccacccaa tgaaaaagga accagtgatt
     1321 tacttgcttg ggacccccta tttggaccat ctcttgattc atcttcttca tcttcactaa
     1381 cttcatcatc atcagccagg cccacaactc ctctttctgt aggcaccatt gtcccacctc
     1441 cgaggcctgc ttccagacca aagcttactt caggcaaact cagtgggatt aatgaaatac
     1501 ccaggccatt cagcccacct gtaacttcca acaccagccc acctcctgct gcaccattag
     1561 cccgggcaga aagttcttct tctatctcat catctgcttc attgagtgct gccaatactc
     1621 caacagtagg tgtgtcacgg ggtcccagcc ctgtcagcct tggaaatcag gataccttac
     1681 ctgtggcagt tgcccttaca gaatctgtta atgcctactt taaaggagca gatcccacca
     1741 agtgtattgt gaagatcact ggtgatatga caatgtcatt tccaagtgga attattaaag
     1801 tcttcaccag caatccaact ccagctgtgt tgtgcttcag ggtgaaaaat atcagcagac
     1861 tagagcagat tcttccaaat gcacagcttg tgttcagtga tccatcacaa tgtgattcca
     1921 acacaaaaga tttttggatg aacatgcaag ctgttacagt ctacctcaag aagctgtcag
     1981 agcaaaatcc agctgcttct tattataatg tagatgtatt aaagtatcag gtatcatcaa
     2041 atggtattca gtccactcct ctgaatcttg caacatactg gaaatgtagt gctagcacca
     2101 cagatcttag agtggattat aaatacaatc cagaagctat ggtggcacct agtgtgcttt
     2161 ccaacataca ggtggtggta ccagtggatg gaggagtaac gaacatgcag tcccttcccc
     2221 ctgcaatatg gaatgcagaa caaatgaaag ccttttggaa attgtctagt atttcagaaa
     2281 aatcagaaaa tggaggttct gggtccctcc gagcaaaatt tgatctttca gaaggaccta
     2341 gtaaacccac gacacttgca gtacaattcc tcagcgaggg aagtaccctt tcaggagtag
     2401 atttcgaact tgtgggcact ggctataggc tttccttaat aaagaagcgg tttgctactg
     2461 gacgatacct ggcggattgt tgatggacct gggaaagtga tgtggcttca gggattacaa
     2521 acctgccatt ctgcattatc tgttctttcc aaacactatt ttaacttgta tgatgtcttt
     2581 caaacttaga catatttgag agctgactac aaacattaaa tcgcactttt aaagtgagtc
     2641 attgaaataa atagtactga aatgattctc tatgttgtaa atgatcaact acaatattca
     2701 ggaagcacat ttattcagat tctcagtaaa aatgaagttt ttgtaggatt aatttttaaa
     2761 ttatttccag tgtctatgtt gaaaaaaagg gttatagtgt aatatcaggc ctaaagtttc
     2821 agaagagcaa gcacaaagta atttagcttt ccatacattt ttagagtcag agataacttt
     2881 gaaatttcat aagtttgata ttcagtggat acaaatagaa catgaattct aagttttggg
     2941 taatgttaac tcagaacact taatcaaatt gagctatgtg ccataaggta atcagaccag
     3001 agtccaagtt gtatgcaaaa aatctataat ttgattctca taaacatatt aataaagtat
     3061 aagtgatgtt ttatatgatt tttaaaaaaa attctcaagt gcaatgtgtt ttaaaataag
     3121 cttgcaaatg acagcagaga catttacttc tgcagttagt taactttata ggagttgtga
     3181 tttttttgat gaattaatgc tgtagattta atttattttt atatggaatt gcataatgtg
     3241 tgccttttaa aacaataaca aaaaccagag atgtgcctat acaatttgtg ttcattaatg
     3301 tgcctcactt tttttctcag tctgaatctt ctgttcagaa tcttacagtg atcaagcatt
     3361 tttataagat atttgcaatt tttgtaaata tttttggcct gcaactggga aggggattca
     3421 gagtcataaa gcctaactta agaatcctgg ctcacttctt tggtgataca ctgtagccac
     3481 tagaaagaga aataaaccca atggcatgtg tttacaggaa gaaagattac cttcagatac
     3541 ttgacattaa cctcatcaaa agtgtgtgaa ttttaaaaca aattctaaaa aaactatagt
     3601 gctaaattgg taactggtat tttaactctc aatttagcat tttccttgat actttatcat
     3661 tgaaaattta tgcatttatt tactgattgt gttgtgaaca tgagttttat ggtattttgt
     3721 gagggatgca ttttttaaaa gattaatttt ggaaacagaa ggagaagcac tgccatttgt
     3781 ttttatttca acaattggaa aaattaccaa tttgtacatt ttaattattc aatttctact
     3841 ttgtaaaaat agggaaatta tttgaagtga tatatttggt taaacatttc taaaaataaa
     3901 ctaccaatac taaatagtaa gaaacctaac tttagtagca aatcttgatt aattgaagaa
     3961 ataaaatatt tcggataagg tttcataatt tacaaatggg aatttcattt ataataataa
     4021 atatgagtgt cctttatttg cctagtagaa gtgataaatt gtgttatata tgataattta
     4081 tataaaacca ctaattgttc cgttaagctt cacagaaaat aaaacctcta ttactagaca
     4141 tttatgtaac atcttgctgt actaaataca gcagaaaatc tactctttag caatatataa
     4201 cacagtatat gcttttttat atattcaatg ttagcccaag tctgaattta catttgacta
     4261 aagcagcaca taagataatt tgctaaaatg ctaatcttta ctaaatagtg agctaaatta
     4321 gaatttctaa ctcttatatt gtgctctttt aaatgccaat tacagtccct tactggaatt
     4381 ctaactgtaa tttgctttgc aatcaaactg cttttagggc agccaatatt ttattattgg
     4441 aattcagaca ctgttcttac cgtgtttgtt tttaatcaaa tattacctaa aaatgtacaa
     4501 attagtgaaa tggttaaact tctgcacttt cttagttacc acagtcttca taccaagtat
     4561 tgggtacagg ttacaatttt gaagccatat gagtttatat tgattttttt tttccattta
     4621 aaaatccact aatggtgtaa aagagaccag tagattttca atgggaaatg tacctagcaa
     4681 gctggttctt gcttatatat agtgataaac tttgtagctg cctctttaac caagaatttg
     4741 taaacacaac tctaataaat gtgagtttta aaggattgtt atttactact ttggattgta
     4801 attagaacaa tgcacatctg tcttccaaga ttttgtaaat atttttgatt tttttcatta
     4861 aatgtaaatt ttacataaaa gttgtgctct taataaacat gtaatatata attta
//

LOCUS       XM_291242               1551 bp    mRNA    linear   PRI 17-OCT-2003
DEFINITION  Homo sapiens basic transcription factor 2 (BBF2H7), mRNA.
ACCESSION   XM_291242
VERSION     XM_291242.2  GI:37538773
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from an annotated genomic sequence
            (NT_007933) using gene prediction method: GNOMON.
            Also see:
                Documentation of NCBI's Annotation Process
             
            On Oct 7, 2003 this sequence version replaced gi:29737105.
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
     gene            1..1551
                     /gene="BBF2H7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON."
                     /db_xref="GeneID:64764"
     CDS             1..1551
                     /gene="BBF2H7"
                     /note="Accession BC037414 represents LocusID 1026"
                     /codon_start=1
                     /product="similar to OASIS protein; BBF-2 (drosophila)
                     homolog"
                     /protein_id="XP_291242.2"
                     /db_xref="GI:37538774"
                     /db_xref="GeneID:64764"
                     /translation="MGFQSFSGQHSRSGLDLVVQGTKLWLGNAGTHFSELLDEFSQNV
                     LGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITSDSFND
                     DEVESEKWYLSTDFPSTSIKTEPITDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNT
                     GVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNP
                     RLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYP
                     IPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRK
                     KVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQ
                     GYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWD
                     RGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVEL
                     DRRVNTTF"
     misc_feature    862..1026
                     /gene="BBF2H7"
                     /note="bZIP; Region: bZIP transcription factor. The Pfam
                     entry includes the basic region and the leucine zipper
                     region"
                     /db_xref="CDD:pfam00170"
     misc_feature    907..1032
                     /gene="BBF2H7"
                     /note="BRLZ; Region: basic region leucin zipper"
                     /db_xref="CDD:smart00338"
ORIGIN      
        1 atgggattcc agagctttag tggccagcac agcagatcgg gacttgacct tgtagttcag
       61 ggaacaaaac tgtggcttgg aaatgcaggg actcacttct cagaacttct ggatgagttt
      121 tcccagaacg tcttgggtca gctcctgaat gatcctttcc tctcagagaa gagtgtgtca
      181 atggaggtgg aaccttcccc gacgtccccg gcgcctctca tccaggctga gcacagctac
      241 tccctgtgcg aggagcctcg ggcccagtcg cccttcaccc acattaccag tgacagcttc
      301 aatgacgatg aggtggaaag tgagaaatgg tacctgtcta cagacttccc ttcaacatcc
      361 atcaagacag agccaattac agacgaacca cccccaggac tcgttccgtc tgtcactctg
      421 accatcacag ccatctccac cccgttggaa aaggaggaac ctcctctgga aatgaacact
      481 ggggttgatt cctcgtgcca gaccattatt cctaaaatta agctggagcc tcatgaagtg
      541 gatcagtttc taaacttctc tcctaaagaa gccccagtgg accacctgca tttgccgccc
      601 acccctccga gcagtcacgg cagtgactca gagggcagcc tgagtcccaa cccacgcctg
      661 caccccttca gcctgcctca gacccacagc ccctccagag ctgcaccccg ggccccctcc
      721 gccctctcca gctcccctct cctcacggct cctcataaac tgcagggatc aggccctctg
      781 gtcctgacag aggaggagaa gaggaccctg atcgctgagg gctatcccat ccccaccaaa
      841 ttgcccctgt caaaatcaga ggagaaggcc ctgaagaaaa ttcggaggaa gatcaagaat
      901 aagatttctg ctcaggaaag taggagaaag aagaaagaat acatggacag cctggagaaa
      961 aaagtggagt cttgttcaac tgagaacttg gagcttcgga agaaggtaga ggttctagag
     1021 aacactaata ggactctcct tcagcaactc cagaagcttc agactttggt gatgggcaag
     1081 gtttctcgaa cctgcaagtt agctggcacg cagactggca cctgcctcat ggttgtggtg
     1141 ctgtgctttg ccgttgcatt cggcagcttc tttcaaggct acgggcccta tccttctgcc
     1201 accaagatgg ctctgcccag ccagcattcc ctgcaggagc cctacacagc ctccgtggtg
     1261 agatccagaa acctgctgat ctacgaggaa cattctcccc cagaggagtc atccagcccg
     1321 ggctcggctg gggagctggg gggctgggat agaggttcct ccctgctcag ggtgtcaggg
     1381 ctggagtcca ggccggatgt ggatcttccc catttcatta tctcgaatga gaccagcctg
     1441 gagaagtcag tgcttttgga gctgcagcag cacctggtca gcgccaaact ggaggggaat
     1501 gaaacactaa aagttgtaga actcgacaga agagtgaaca ccactttcta a
//

